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Judith A Van de Water, PhD

Title(s)Professor, Rheumatology, Allergy, And Clinical Immunology
SchoolUniversity of California, Davis
Phone530-752-2154
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    Collapse Research 
    Collapse Research Activities and Funding
    Maternal inflammation during pregnancy and neurodevelopmental disorders
    NIH/NICHD R01HD095128Jul 15, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Interdisciplinary Investigation of Biological Signatures of Autism Subtypes
    NIH/NIMH R01MH089626Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Gene Expression and Immune Cell Function in Mothers of Children with Autism
    NIH/NICHD R21HD065269Sep 30, 2009 - Aug 31, 2011
    Role: Co-Principal Investigator
    The UC Davis Center for Children's Enviromental Health and Disease Prevention
    NIH/NIEHS P01ES011269Sep 30, 2001 - May 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bruce M, Streifel KM, Boosalis CA, Heuer L, González EA, Li S, Harvey DJ, Lein PJ, Van de Water J. Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain. J Neuroinflammation. 2019 Oct 31; 16(1):200. PMID: 31672161.
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    2. Heuer LS, Croen LA, Jones KL, Yoshida CK, Hansen RL, Yolken R, Zerbo O, DeLorenze G, Kharrazi M, Ashwood P, Van de Water J. An Exploratory Examination of Neonatal Cytokines and Chemokines as Predictors of Autism Risk: The Early Markers for Autism Study. Biol Psychiatry. 2019 Aug 15; 86(4):255-264. PMID: 31279535.
      View in: PubMed
    3. Hertz-Picciotto I, Schmidt RJ, Walker CK, Bennett DH, Oliver M, Shedd-Wise KM, LaSalle JM, Giulivi C, Puschner B, Thomas J, Roa DL, Pessah IN, Van de Water J, Tancredi DJ, Ozonoff S. A Prospective Study of Environmental Exposures and Early Biomarkers in Autism Spectrum Disorder: Design, Protocols, and Preliminary Data from the MARBLES Study. Environ Health Perspect. 2018 11; 126(11):117004. PMID: 30465702.
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    4. Traglia M, Croen LA, Jones KL, Heuer LS, Yolken R, Kharrazi M, DeLorenze GN, Ashwood P, Van de Water J, Weiss LA. Cross-genetic determination of maternal and neonatal immune mediators during pregnancy. Genome Med. 2018 08 22; 10(1):67. PMID: 30134952.
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    5. Careaga M, Taylor SL, Chang C, Chiang A, Ku KM, Berman RF, Van de Water JA, Bauman MD. Variability in PolyIC induced immune response: Implications for preclinical maternal immune activation models. J Neuroimmunol. 2018 10 15; 323:87-93. PMID: 30196839.
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    6. Jones KL, Van de Water J. Maternal autoantibody related autism: mechanisms and pathways. Mol Psychiatry. 2019 02; 24(2):252-265. PMID: 29934547.
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    7. Lesh TA, Careaga M, Rose DR, McAllister AK, Van de Water J, Carter CS, Ashwood P. Cytokine alterations in first-episode schizophrenia and bipolar disorder: relationships to brain structure and symptoms. J Neuroinflammation. 2018 May 26; 15(1):165. PMID: 29803226.
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    8. Rose DR, Yang H, Serena G, Sturgeon C, Ma B, Careaga M, Hughes HK, Angkustsiri K, Rose M, Hertz-Picciotto I, Van de Water J, Hansen RL, Ravel J, Fasano A, Ashwood P. Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms. Brain Behav Immun. 2018 05; 70:354-368. PMID: 29571898.
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    9. Edmiston E, Jones KL, Vu T, Ashwood P, Van de Water J. Identification of the antigenic epitopes of maternal autoantibodies in autism spectrum disorders. Brain Behav Immun. 2018 03; 69:399-407. PMID: 29289663.
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    10. Ariza J, Hurtado J, Rogers H, Ikeda R, Dill M, Steward C, Creary D, Van de Water J, Martínez-Cerdeño V. Maternal autoimmune antibodies alter the dendritic arbor and spine numbers in the infragranular layers of the cortex. PLoS One. 2017; 12(8):e0183443. PMID: 28820892.
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    11. Sowell KD, Uriu-Adams JY, Van de Water J, Chambers CD, Coles CD, Kable JA, Yevtushok L, Zymak-Zakutnya N, Wertelecki W, Keen CL. Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure. Alcohol. 2018 05; 68:49-58. PMID: 29453023.
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    12. Amaral DG, Li D, Libero L, Solomon M, Van de Water J, Mastergeorge A, Naigles L, Rogers S, Wu Nordahl C. In pursuit of neurophenotypes: The consequences of having autism and a big brain. Autism Res. 2017 May; 10(5):711-722. PMID: 28239961.
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    13. Rose DR, Careaga M, Van de Water J, McAllister K, Bauman MD, Ashwood P. Long-term altered immune responses following fetal priming in a non-human primate model of maternal immune activation. Brain Behav Immun. 2017 Jul; 63:60-70. PMID: 27876552.
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    14. Edmiston E, Ashwood P, Van de Water J. Autoimmunity, Autoantibodies, and Autism Spectrum Disorder. Biol Psychiatry. 2017 03 01; 81(5):383-390. PMID: 28340985.
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    15. Meltzer A, Van de Water J. The Role of the Immune System in Autism Spectrum Disorder. Neuropsychopharmacology. 2017 01; 42(1):284-298. PMID: 27534269.
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    16. Krakowiak P, Walker CK, Tancredi D, Hertz-Picciotto I, Van de Water J. Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions. Autism Res. 2017 Jan; 10(1):89-98. PMID: 27312731.
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    17. Jones KL, Croen LA, Yoshida CK, Heuer L, Hansen R, Zerbo O, DeLorenze GN, Kharrazi M, Yolken R, Ashwood P, Van de Water J. Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation. Mol Psychiatry. 2017 02; 22(2):273-279. PMID: 27217154.
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    18. Zerbo O, Traglia M, Yoshida C, Heuer LS, Ashwood P, Delorenze GN, Hansen RL, Kharrazi M, Van de Water J, Yolken RH, Weiss LA, Croen LA. Maternal mid-pregnancy C-reactive protein and risk of autism spectrum disorders: the early markers for autism study. Transl Psychiatry. 2016 Apr 19; 6:e783. PMID: 27093065.
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    19. Matelski L, Van de Water J. Risk factors in autism: Thinking outside the brain. J Autoimmun. 2016 Feb; 67:1-7. PMID: 26725748.
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    20. Zerbo O, Qian Y, Yoshida C, Grether JK, Van de Water J, Croen LA. Maternal Infection During Pregnancy and Autism Spectrum Disorders. J Autism Dev Disord. 2015 Dec; 45(12):4015-25. PMID: 24366406.
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    21. Careaga M, Rogers S, Hansen RL, Amaral DG, Van de Water J, Ashwood P. Immune Endophenotypes in Children With Autism Spectrum Disorder. Biol Psychiatry. 2017 03 01; 81(5):434-441. PMID: 26493496.
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    22. Fox-Edmiston E, Van de Water J. Maternal Anti-Fetal Brain IgG Autoantibodies and Autism Spectrum Disorder: Current Knowledge and its Implications for Potential Therapeutics. CNS Drugs. 2015 Sep; 29(9):715-24. PMID: 26369920.
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    23. Krakowiak P, Goines PE, Tancredi DJ, Ashwood P, Hansen RL, Hertz-Picciotto I, Van de Water J. Neonatal Cytokine Profiles Associated With Autism Spectrum Disorder. Biol Psychiatry. 2017 03 01; 81(5):442-451. PMID: 26392128.
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    24. Akintunde ME, Rose M, Krakowiak P, Heuer L, Ashwood P, Hansen R, Hertz-Picciotto I, Van de Water J. Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma. J Neuroimmunol. 2015 Sep 15; 286:33-41. PMID: 26298322.
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    25. Sun Y, Haapanen K, Li B, Zhang W, Van de Water J, Gershwin ME. Women and primary biliary cirrhosis. Clin Rev Allergy Immunol. 2015 Jun; 48(2-3):285-300. PMID: 25241227.
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    26. Lyall K, Van de Water J, Ashwood P, Hertz-Picciotto I. Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study. Autism Res. 2015 Oct; 8(5):567-74. PMID: 25722050.
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    27. Martínez-Cerdeño V, Camacho J, Fox E, Miller E, Ariza J, Kienzle D, Plank K, Noctor SC, Van de Water J. Prenatal Exposure to Autism-Specific Maternal Autoantibodies Alters Proliferation of Cortical Neural Precursor Cells, Enlarges Brain, and Increases Neuronal Size in Adult Animals. Cereb Cortex. 2016 Jan; 26(1):374-383. PMID: 25535268.
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    28. Lyall K, Ashwood P, Van de Water J, Hertz-Picciotto I. Maternal immune-mediated conditions, autism spectrum disorders, and developmental delay. J Autism Dev Disord. 2014 Jul; 44(7):1546-55. PMID: 24337796.
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    29. Zerbo O, Yoshida C, Grether JK, Van de Water J, Ashwood P, Delorenze GN, Hansen RL, Kharrazi M, Croen LA. Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: the Early Markers for Autism (EMA) study: a case-control study. J Neuroinflammation. 2014 Jun 20; 11:113. PMID: 24951035.
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    30. Careaga M, Noyon T, Basuta K, Van de Water J, Tassone F, Hagerman RJ, Ashwood P. Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome. J Neuroinflammation. 2014 Jun 19; 11:110. PMID: 24942544.
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    31. Camacho J, Jones K, Miller E, Ariza J, Noctor S, de Water JV, Martínez-Cerdeño V. Embryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autistic-like stereotypical behaviors in offspring mice. Behav Brain Res. 2014 Jun 01; 266:46-51. PMID: 24613242.
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    32. Piras IS, Haapanen L, Napolioni V, Sacco R, Van de Water J, Persico AM. Anti-brain antibodies are associated with more severe cognitive and behavioral profiles in Italian children with Autism Spectrum Disorder. Brain Behav Immun. 2014 May; 38:91-9. PMID: 24389156.
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    33. Careaga M, Hansen RL, Hertz-Piccotto I, Van de Water J, Ashwood P. Increased anti-phospholipid antibodies in autism spectrum disorders. Mediators Inflamm. 2013; 2013:935608. PMID: 24174712.
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    34. Braunschweig D, Krakowiak P, Duncanson P, Boyce R, Hansen RL, Ashwood P, Hertz-Picciotto I, Pessah IN, Van de Water J. Autism-specific maternal autoantibodies recognize critical proteins in developing brain. Transl Psychiatry. 2013 Jul 09; 3:e277. PMID: 23838888.
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    35. Bauman MD, Iosif AM, Ashwood P, Braunschweig D, Lee A, Schumann CM, Van de Water J, Amaral DG. Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey. Transl Psychiatry. 2013 Jul 09; 3:e278. PMID: 23838889.
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    36. Nordahl CW, Braunschweig D, Iosif AM, Lee A, Rogers S, Ashwood P, Amaral DG, Van de Water J. Maternal autoantibodies are associated with abnormal brain enlargement in a subgroup of children with autism spectrum disorder. Brain Behav Immun. 2013 May; 30:61-5. PMID: 23395715.
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    37. Breece E, Paciotti B, Nordahl CW, Ozonoff S, Van de Water JA, Rogers SJ, Amaral D, Ashwood P. Myeloid dendritic cells frequencies are increased in children with autism spectrum disorder and associated with amygdala volume and repetitive behaviors. Brain Behav Immun. 2013 Jul; 31:69-75. PMID: 23063420.
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    38. Fox E, Amaral D, Van de Water J. Maternal and fetal antibrain antibodies in development and disease. Dev Neurobiol. 2012 Oct; 72(10):1327-34. PMID: 22911883.
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    39. Braunschweig D, Golub MS, Koenig CM, Qi L, Pessah IN, Van de Water J, Berman RF. Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model. J Neuroimmunol. 2012 Nov 15; 252(1-2):56-65. PMID: 22951357.
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    40. Winarni TI, Chonchaiya W, Sumekar TA, Ashwood P, Morales GM, Tassone F, Nguyen DV, Faradz SM, Van de Water J, Cook K, Hamlin A, Mu Y, Hagerman PJ, Hagerman RJ. Immune-mediated disorders among women carriers of fragile X premutation alleles. Am J Med Genet A. 2012 Oct; 158A(10):2473-81. PMID: 22903889.
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    41. Heuer LS, Rose M, Ashwood P, Van de Water J. Decreased levels of total immunoglobulin in children with autism are not a result of B cell dysfunction. J Neuroimmunol. 2012 Oct 15; 251(1-2):94-102. PMID: 22854260.
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    42. Braunschweig D, Duncanson P, Boyce R, Hansen R, Ashwood P, Pessah IN, Hertz-Picciotto I, Van de Water J. Behavioral correlates of maternal antibody status among children with autism. J Autism Dev Disord. 2012 Jul; 42(7):1435-45. PMID: 22012245.
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    43. Onore CE, Nordahl CW, Young GS, Van de Water JA, Rogers SJ, Ashwood P. Levels of soluble platelet endothelial cell adhesion molecule-1 and P-selectin are decreased in children with autism spectrum disorder. Biol Psychiatry. 2012 Dec 15; 72(12):1020-5. PMID: 22717029.
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    44. Braunschweig D, Van de Water J. Maternal autoantibodies in autism. Arch Neurol. 2012 Jun; 69(6):693-9. PMID: 22689191.
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    45. Heuer L, Braunschweig D, Ashwood P, Van de Water J, Campbell DB. Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression. Transl Psychiatry. 2011 Oct 18; 1:e48. PMID: 22833194.
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    46. Goines PE, Croen LA, Braunschweig D, Yoshida CK, Grether J, Hansen R, Kharrazi M, Ashwood P, Van de Water J. Increased midgestational IFN-?, IL-4 and IL-5 in women bearing a child with autism: A case-control study. Mol Autism. 2011 Aug 02; 2:13. PMID: 21810230.
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    47. Ashwood P, Corbett BA, Kantor A, Schulman H, Van de Water J, Amaral DG. In search of cellular immunophenotypes in the blood of children with autism. PLoS One. 2011 May 04; 6(5):e19299. PMID: 21573236.
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    48. Wills S, Rossi CC, Bennett J, Martinez-Cerdeño V, Ashwood P, Amaral DG, Van de Water J. Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism. Mol Autism. 2011 Apr 26; 2:5. PMID: 21521495.
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    49. Rossi CC, Van de Water J, Rogers SJ, Amaral DG. Detection of plasma autoantibodies to brain tissue in young children with and without autism spectrum disorders. Brain Behav Immun. 2011 Aug; 25(6):1123-35. PMID: 21420487.
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    50. Goines P, Haapanen L, Boyce R, Duncanson P, Braunschweig D, Delwiche L, Hansen R, Hertz-Picciotto I, Ashwood P, Van de Water J. Autoantibodies to cerebellum in children with autism associate with behavior. Brain Behav Immun. 2011 Mar; 25(3):514-23. PMID: 21134442.
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    51. Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J. Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. J Neuroimmunol. 2011 Mar; 232(1-2):196-9. PMID: 21095018.
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    52. Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J. Altered T cell responses in children with autism. Brain Behav Immun. 2011 Jul; 25(5):840-9. PMID: 20833247.
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    53. Lleo A, Bowlus CL, Yang GX, Invernizzi P, Podda M, Van de Water J, Ansari AA, Coppel RL, Worman HJ, Gores GJ, Gershwin ME. Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology. 2010 Sep; 52(3):987-98. PMID: 20568301.
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    54. Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun. 2011 Jan; 25(1):40-5. PMID: 20705131.
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    55. Careaga M, Van de Water J, Ashwood P. Immune dysfunction in autism: a pathway to treatment. Neurotherapeutics. 2010 Jul; 7(3):283-92. PMID: 20643381.
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    56. Goines P, Van de Water J. The immune system's role in the biology of autism. Curr Opin Neurol. 2010 Apr; 23(2):111-7. PMID: 20160651.
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    57. Buie T, Campbell DB, Fuchs GJ, Furuta GT, Levy J, Vandewater J, Whitaker AH, Atkins D, Bauman ML, Beaudet AL, Carr EG, Gershon MD, Hyman SL, Jirapinyo P, Jyonouchi H, Kooros K, Kushak R, Levitt P, Levy SE, Lewis JD, Murray KF, Natowicz MR, Sabra A, Wershil BK, Weston SC, Zeltzer L, Winter H. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics. 2010 Jan; 125 Suppl 1:S1-18. PMID: 20048083.
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    58. Stamova B, Green PG, Tian Y, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Teng J, Gregg JP, Ashwood P, Van de Water J, Sharp FR. Correlations between gene expression and mercury levels in blood of boys with and without autism. Neurotox Res. 2011 Jan; 19(1):31-48. PMID: 19937285.
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    59. Tian Y, Green PG, Stamova B, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Gregg JP, Ashwood P, Jickling G, Van de Water J, Sharp FR. Correlations of gene expression with blood lead levels in children with autism compared to typically developing controls. Neurotox Res. 2011 Jan; 19(1):1-13. PMID: 19921347.
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    60. Wu YW, Croen LA, Torres AR, Van De Water J, Grether JK, Hsu NN. Interleukin-6 genotype and risk for cerebral palsy in term and near-term infants. Ann Neurol. 2009 Nov; 66(5):663-70. PMID: 19938160.
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    61. McAllister AK, van de Water J. Breaking boundaries in neural-immune interactions. Neuron. 2009 Oct 15; 64(1):9-12. PMID: 19840540.
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    62. Onore C, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen R, Van de Water J, Ashwood P. Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders. J Neuroimmunol. 2009 Nov 30; 216(1-2):126-9. PMID: 19800697.
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    63. Enstrom AM, Onore CE, Van de Water JA, Ashwood P. Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain Behav Immun. 2010 Jan; 24(1):64-71. PMID: 19666104.
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    64. Enstrom AM, Van de Water JA, Ashwood P. Autoimmunity in autism. Curr Opin Investig Drugs. 2009 May; 10(5):463-73. PMID: 19431079.
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    65. Lleo A, Selmi C, Invernizzi P, Podda M, Coppel RL, Mackay IR, Gores GJ, Ansari AA, Van de Water J, Gershwin ME. Apotopes and the biliary specificity of primary biliary cirrhosis. Hepatology. 2009 Mar; 49(3):871-9. PMID: 19185000.
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    66. Ashwood P, Schauer J, Pessah IN, Van de Water J. Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders. J Neuroimmunol. 2009 Mar 31; 208(1-2):130-5. PMID: 19211157.
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    67. Enstrom A, Krakowiak P, Onore C, Pessah IN, Hertz-Picciotto I, Hansen RL, Van de Water JA, Ashwood P. Increased IgG4 levels in children with autism disorder. Brain Behav Immun. 2009 Mar; 23(3):389-95. PMID: 19136055.
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    68. Ashwood P, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen RL, Croen LA, Ozonoff S, Pessah IN, Van de Water J. Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes. J Neuroimmunol. 2008 Nov 15; 204(1-2):149-53. PMID: 18762342.
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    69. Heuer L, Ashwood P, Schauer J, Goines P, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen LA, Pessah IN, Van de Water J. Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms. Autism Res. 2008 Oct; 1(5):275-83. PMID: 19343198.
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    70. Enstrom AM, Lit L, Onore CE, Gregg JP, Hansen RL, Pessah IN, Hertz-Picciotto I, Van de Water JA, Sharp FR, Ashwood P. Altered gene expression and function of peripheral blood natural killer cells in children with autism. Brain Behav Immun. 2009 Jan; 23(1):124-33. PMID: 18762240.
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    71. Wills S, Cabanlit M, Bennett J, Ashwood P, Amaral DG, Van de Water J. Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders. Brain Behav Immun. 2009 Jan; 23(1):64-74. PMID: 18706993.
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    72. Croen LA, Braunschweig D, Haapanen L, Yoshida CK, Fireman B, Grether JK, Kharrazi M, Hansen RL, Ashwood P, Van de Water J. Maternal mid-pregnancy autoantibodies to fetal brain protein: the early markers for autism study. Biol Psychiatry. 2008 Oct 01; 64(7):583-8. PMID: 18571628.
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    73. Nagarajan RP, Patzel KA, Martin M, Yasui DH, Swanberg SE, Hertz-Picciotto I, Hansen RL, Van de Water J, Pessah IN, Jiang R, Robinson WP, LaSalle JM. MECP2 promoter methylation and X chromosome inactivation in autism. Autism Res. 2008 Jun; 1(3):169-78. PMID: 19132145.
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    74. Croen LA, Goines P, Braunschweig D, Yolken R, Yoshida CK, Grether JK, Fireman B, Kharrazi M, Hansen RL, Van de Water J. Brain-derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) Study. Autism Res. 2008 Apr; 1(2):130-7. PMID: 19119429.
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    75. Pessah IN, Seegal RF, Lein PJ, LaSalle J, Yee BK, Van De Water J, Berman RF. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology. 2008 May; 29(3):532-45. PMID: 18394707.
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    76. Martin LA, Ashwood P, Braunschweig D, Cabanlit M, Van de Water J, Amaral DG. Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain Behav Immun. 2008 Aug; 22(6):806-16. PMID: 18262386.
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    77. Braunschweig D, Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen LA, Pessah IN, Van de Water J. Autism: maternally derived antibodies specific for fetal brain proteins. Neurotoxicology. 2008 Mar; 29(2):226-31. PMID: 18078998.
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    78. Wills S, Cabanlit M, Bennett J, Ashwood P, Amaral D, Van de Water J. Autoantibodies in autism spectrum disorders (ASD). Ann N Y Acad Sci. 2007 Jun; 1107:79-91. PMID: 17804535.
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    79. Cabanlit M, Wills S, Goines P, Ashwood P, Van de Water J. Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Ann N Y Acad Sci. 2007 Jun; 1107:92-103. PMID: 17804536.
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    80. Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P, Walker W, Pessah IN, Van de Water J. Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? J Autism Dev Disord. 2008 Jan; 38(1):169-75. PMID: 17347881.
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    81. Foreman AL, Van de Water J, Gougeon ML, Gershwin ME. B cells in autoimmune diseases: insights from analyses of immunoglobulin variable (Ig V) gene usage. Autoimmun Rev. 2007 Jun; 6(6):387-401. PMID: 17537385.
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    82. Allina J, Hu B, Sullivan DM, Fiel MI, Thung SN, Bronk SF, Huebert RC, van de Water J, LaRusso NF, Gershwin ME, Gores GJ, Odin JA. T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis. J Autoimmun. 2006 Dec; 27(4):232-41. PMID: 17222534.
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    83. Cabanlit M, Maitland D, Wilson T, Simon S, Wun T, Gershwin ME, Van de Water J. Polyurethane shape-memory polymers demonstrate functional biocompatibility in vitro. Macromol Biosci. 2007 Jan 05; 7(1):48-55. PMID: 17238230.
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    84. Hertz-Picciotto I, Croen LA, Hansen R, Jones CR, van de Water J, Pessah IN. The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environ Health Perspect. 2006 Jul; 114(7):1119-25. PMID: 16835068.
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    85. Ashwood P, Wills S, Van de Water J. The immune response in autism: a new frontier for autism research. J Leukoc Biol. 2006 Jul; 80(1):1-15. PMID: 16698940.
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    86. Bu B, Ashwood P, Harvey D, King IB, Water JV, Jin LW. Fatty acid compositions of red blood cell phospholipids in children with autism. Prostaglandins Leukot Essent Fatty Acids. 2006 Apr; 74(4):215-21. PMID: 16581239.
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    87. Croen LA, Grether JK, Yoshida CK, Odouli R, Van de Water J. Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study. Arch Pediatr Adolesc Med. 2005 Feb; 159(2):151-7. PMID: 15699309.
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    88. Mao TK, Van de Water J, Gershwin ME. Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients. J Med Food. 2005; 8(1):27-30. PMID: 15857205.
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    89. Ashwood P, Van de Water J. Is autism an autoimmune disease? Autoimmun Rev. 2004 Nov; 3(7-8):557-62. PMID: 15546805.
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    90. Ashwood P, Van de Water J. A review of autism and the immune response. Clin Dev Immunol. 2004 Jun; 11(2):165-74. PMID: 15330453.
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    91. Matsumura S, Van De Water J, Leung P, Odin JA, Yamamoto K, Gores GJ, Mostov K, Ansari AA, Coppel RL, Shiratori Y, Gershwin ME. Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis. Hepatology. 2004 May; 39(5):1415-22. PMID: 15122771.
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    92. Lawler CP, Croen LA, Grether JK, Van de Water J. Identifying environmental contributions to autism: provocative clues and false leads. Ment Retard Dev Disabil Res Rev. 2004; 10(4):292-302. PMID: 15666339.
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    93. Bruggraber SF, Leung PS, Amano K, Quan C, Kurth MJ, Nantz MH, Benson GD, Van de Water J, Luketic V, Roche TE, Ansari AA, Coppel RL, Gershwin ME. Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis. Gastroenterology. 2003 Dec; 125(6):1705-13. PMID: 14724823.
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    94. Selmi C, Balkwill DL, Invernizzi P, Ansari AA, Coppel RL, Podda M, Leung PS, Kenny TP, Van De Water J, Nantz MH, Kurth MJ, Gershwin ME. Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov; 38(5):1250-7. PMID: 14578864.
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    95. Wu CT, Eiserich JP, Ansari AA, Coppel RL, Balasubramanian S, Bowlus CL, Gershwin ME, Van De Water J. Myeloperoxidase-positive inflammatory cells participate in bile duct damage in primary biliary cirrhosis through nitric oxide-mediated reactions. Hepatology. 2003 Oct; 38(4):1018-25. PMID: 14512889.
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    96. Kita H, Ansari AA, He XS, Lian ZX, Van de Water J, Coppel RL, Luketic V, Kaplan M, Inamori H, Isoda N, Sugano K, Imawari M, Gershwin ME. Proteasome is required for class I-restricted presentation by Fcgamma receptor-mediated endocytosis in primary biliary cirrhosis. J Autoimmun. 2003 Sep; 21(2):175-82. PMID: 12935787.
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    97. Leung PS, Quan C, Park O, Van de Water J, Kurth MJ, Nantz MH, Ansari AA, Coppel RL, Lam KS, Gershwin ME. Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies. J Immunol. 2003 May 15; 170(10):5326-32. PMID: 12734383.
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    98. Mao TK, Van De Water J, Keen CL, Schmitz HH, Gershwin ME. Cocoa flavonols and procyanidins promote transforming growth factor-beta1 homeostasis in peripheral blood mononuclear cells. Exp Biol Med (Maywood). 2003 Jan; 228(1):93-9. PMID: 12524479.
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    99. Fukushima N, Nalbandian G, Van De Water J, White K, Ansari AA, Leung P, Kenny T, Kamita SG, Hammock BD, Coppel RL, Stevenson F, Ishibashi H, Gershwin ME. Characterization of recombinant monoclonal IgA anti-PDC-E2 autoantibodies derived from patients with PBC. Hepatology. 2002 Dec; 36(6):1383-92. PMID: 12447863.
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    100. Mao TK, Kimura Y, Kenny TP, Branchi A, Gishi RG, Van de Water J, Kung HJ, Friedman SL, Gershwin ME. Elevated expression of tyrosine kinase DDR2 in primary biliary cirrhosis. Autoimmunity. 2002 Dec; 35(8):521-9. PMID: 12765478.
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    101. Neale JC, van de Water JA, Harvey JT, Tjeerdema RS, Gershwin ME. Proliferative responses of harbor seal (Phoca vitulina) T lymphocytes to model marine pollutants. Dev Immunol. 2002 Dec; 9(4):215-21. PMID: 15144018.
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    102. Matsumura S, Kita H, He XS, Ansari AA, Lian ZX, Van De Water J, Yamamoto K, Tsuji T, Coppel RL, Kaplan M, Gershwin ME. Comprehensive mapping of HLA-A0201-restricted CD8 T-cell epitopes on PDC-E2 in primary biliary cirrhosis. Hepatology. 2002 Nov; 36(5):1125-34. PMID: 12395322.
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    103. Kimura Y, Leung PS, Kenny TP, Van De Water J, Nishioka M, Giraud AS, Neuberger J, Benson G, Kaul R, Ansari AA, Coppel RL, Gershwin ME. Differential expression of intestinal trefoil factor in biliary epithelial cells of primary biliary cirrhosis. Hepatology. 2002 Nov; 36(5):1227-35. PMID: 12395334.
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    104. Kita H, Matsumura S, He XS, Ansari AA, Lian ZX, Van de Water J, Coppel RL, Kaplan MM, Gershwin ME. Analysis of TCR antagonism and molecular mimicry of an HLA-A0201-restricted CTL epitope in primary biliary cirrhosis. Hepatology. 2002 Oct; 36(4 Pt 1):918-26. PMID: 12297839.
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    105. Kita H, Naidenko OV, Kronenberg M, Ansari AA, Rogers P, He XS, Koning F, Mikayama T, Van De Water J, Coppel RL, Kaplan M, Gershwin ME. Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer. Gastroenterology. 2002 Oct; 123(4):1031-43. PMID: 12360465.
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    106. Mao TK, van de Water J, Keen CL, Schmitz HH, Gershwin ME. Modulation of TNF-alpha secretion in peripheral blood mononuclear cells by cocoa flavanols and procyanidins. Dev Immunol. 2002 Sep; 9(3):135-41. PMID: 12885154.
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    107. Suzuki A, Van de Water J, Gershwin ME, Jorgensen R, Angulo P, Lindor K. Oral tolerance and pyruvate dehydrogenase in patients with primary biliary cirrhosis. Dev Immunol. 2002 Jun; 9(2):55-61. PMID: 12739782.
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    108. Kita H, Matsumura S, He XS, Ansari AA, Lian ZX, Van de Water J, Coppel RL, Kaplan MM, Gershwin ME. Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis. J Clin Invest. 2002 May; 109(9):1231-40. PMID: 11994412.
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    109. Sasaki M, Long SA, Van De Water J, He XS, Shultz L, Coppel RL, Ansari A, Nakanuma Y, Gershwin ME. The SJL/J mouse is not a model for PBC. Hepatology. 2002 May; 35(5):1284-6. PMID: 11981783.
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    110. Korvatska E, Van de Water J, Anders TF, Gershwin ME. Genetic and immunologic considerations in autism. Neurobiol Dis. 2002 Mar; 9(2):107-25. PMID: 11895365.
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    111. Long SA, Van de Water J, Gershwin ME. Antimitochondrial antibodies in primary biliary cirrhosis: the role of xenobiotics. Autoimmun Rev. 2002 Feb; 1(1-2):37-42. PMID: 12849056.
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    112. Kita H, Lian ZX, Van de Water J, He XS, Matsumura S, Kaplan M, Luketic V, Coppel RL, Ansari AA, Gershwin ME. Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells. J Exp Med. 2002 Jan 07; 195(1):113-23. PMID: 11781370.
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    113. Matsumura S, Van De Water J, Kita H, Coppel RL, Tsuji T, Yamamoto K, Ansari AA, Gershwin ME. Contribution to antimitochondrial antibody production: cleavage of pyruvate dehydrogenase complex-E2 by apoptosis-related proteases. Hepatology. 2002 Jan; 35(1):14-22. PMID: 11786955.
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    114. Mao TK, Van de Water J, Keen CL, Schmitz HH, Gershwin ME. Effect of cocoa flavanols and their related oligomers on the secretion of interleukin-5 in peripheral blood mononuclear cells. J Med Food. 2002; 5(1):17-22. PMID: 12511109.
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    115. Sasaki M, Van De Water J, Kenny TP, Gallo ML, Leung PS, Nakanuma Y, Ansari AA, Coppel RL, Neuberger J, Gershwin ME. Immunoglobulin gene usage and immunohistochemical characteristics of human monoclonal antibodies to the mitochondrial autoantigens of primary biliary cirrhosis induced in the XenoMouse. Hepatology. 2001 Oct; 34(4 Pt 1):631-7. PMID: 11584357.
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    116. Long SA, Quan C, Van de Water J, Nantz MH, Kurth MJ, Barsky D, Colvin ME, Lam KS, Coppel RL, Ansari A, Gershwin ME. Immunoreactivity of organic mimeotopes of the E2 component of pyruvate dehydrogenase: connecting xenobiotics with primary biliary cirrhosis. J Immunol. 2001 Sep 01; 167(5):2956-63. PMID: 11509645.
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    117. Gershwin ME, Van de Water J. Cholangiocytes and primary biliary cirrhosis: prediction and predication. J Clin Invest. 2001 Jul; 108(2):187-8. PMID: 11457871.
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    118. Kita H, Mackay IR, Van De Water J, Gershwin ME. The lymphoid liver: considerations on pathways to autoimmune injury. Gastroenterology. 2001 May; 120(6):1485-501. PMID: 11313320.
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    119. Van de Water J, Ishibashi H, Coppel RL, Gershwin ME. Molecular mimicry and primary biliary cirrhosis: premises not promises. Hepatology. 2001 Apr; 33(4):771-5. PMID: 11283838.
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    120. Migliaccio C, Van de Water J, Ansari AA, Kaplan MM, Coppel RL, Lam KS, Thompson RK, Stevenson F, Gershwin ME. Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2: the molecule versus the mimic. Hepatology. 2001 Apr; 33(4):792-801. PMID: 11283841.
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    121. Mao T, Van De Water J, Keen CL, Schmitz HH, Gershwin ME. Cocoa procyanidins and human cytokine transcription and secretion. J Nutr. 2000 08; 130(8S Suppl):2093S-9S. PMID: 10917928.
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    122. Sasaki M, Ansari A, Pumford N, van de Water J, Leung PS, Humphries KM, Szweda LI, Nakanuma Y, Roche TE, Coppel RL, Bach JF, Gershwin ME. Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic. J Autoimmun. 2000 Aug; 15(1):51-60. PMID: 10936028.
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    123. Mao TK, Powell J, Van de Water J, Keen CL, Schmitz HH, Hammerstone JF, Gershwin ME. The effect of cocoa procyanidins on the transcription and secretion of interleukin 1 beta in peripheral blood mononuclear cells. Life Sci. 2000 Mar 03; 66(15):1377-86. PMID: 11210713.
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    124. Mackay IR, Van de Water J, Gershwin ME. Autoimmunity. Thoughts for the millennium. Clin Rev Allergy Immunol. 2000 Feb; 18(1):87-117. PMID: 10907110.
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    125. Van de Water J, Gershwin ME. Detection of molecular determinants in complex biological systems using MALDI-TOF affinity mass spectrometry. Methods Mol Biol. 2000; 146:453-9. PMID: 10948518.
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    126. Reynoso-Paz S, Leung PS, Van De Water J, Tanaka A, Munoz S, Bass N, Lindor K, Donald PJ, Coppel RL, Ansari AA, Gershwin ME. Evidence for a locally driven mucosal response and the presence of mitochondrial antigens in saliva in primary biliary cirrhosis. Hepatology. 2000 Jan; 31(1):24-9. PMID: 10613723.
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    127. Quaranta S, Van de Water J, Ishibashi H, Rosina F, Coppel R, Uibo R, Gershwin ME. The immunopathogenesis of primary biliary cirrhosis. Hepatogastroenterology. 1999 Nov-Dec; 46(30):3041-7. PMID: 10626157.
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    128. Powell JJ, Van de Water J, Gershwin ME. Evidence for the role of environmental agents in the initiation or progression of autoimmune conditions. Environ Health Perspect. 1999 Oct; 107 Suppl 5:667-72. PMID: 10970167.
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    129. Nalbandian G, Van de Water J, Gish R, Manns M, Coppel RL, Rudich SM, Prindiville T, Gershwin ME. Is there a serological difference between men and women with primary biliary cirrhosis? Am J Gastroenterol. 1999 Sep; 94(9):2482-6. PMID: 10484012.
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    130. Tsuji K, Watanabe Y, Van De Water J, Nakanishi T, Kajiyama G, Parikh-Patel A, Coppel R, Gershwin ME. Familial primary biliary cirrhosis in Hiroshima. J Autoimmun. 1999 Aug; 13(1):171-8. PMID: 10441183.
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    131. Van de Water J, Keen CL, Gershwin ME. The influence of chronic yogurt consumption on immunity. J Nutr. 1999 07; 129(7 Suppl):1492S-5S. PMID: 10395628.
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    132. Dubel L, Tanaka A, Leung PS, Van de Water J, Coppel R, Roche T, Johanet C, Motokawa Y, Ansari A, Gershwin ME. Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase-binding protein (E3BP) and the glycine cleavage proteins in primary biliary cirrhosis. Hepatology. 1999 Apr; 29(4):1013-8. PMID: 10094940.
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    133. Katayanagi K, Van de Water J, Kenny T, Nakanuma Y, Ansari AA, Coppel R, Gershwin ME. Generation of monoclonal antibodies to murine bile duct epithelial cells: identification of annexin V as a new marker of small intrahepatic bile ducts. Hepatology. 1999 Apr; 29(4):1019-25. PMID: 10094941.
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    134. Quaranta S, Shulman H, Ahmed A, Shoenfeld Y, Peter J, McDonald GB, Van de Water J, Coppel R, Ostlund C, Worman HJ, Rizzetto M, Tsuneyama K, Nakanuma Y, Ansari A, Locatelli F, Paganin S, Rosina F, Manns M, Gershwin ME. Autoantibodies in human chronic graft-versus-host disease after hematopoietic cell transplantation. Clin Immunol. 1999 Apr; 91(1):106-16. PMID: 10219261.
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    135. Shimoda S, Van de Water J, Ansari A, Nakamura M, Ishibashi H, Coppel RL, Lake J, Keeffe EB, Roche TE, Gershwin ME. Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis. J Clin Invest. 1998 Nov 15; 102(10):1831-40. PMID: 9819369.
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    136. Migliaccio C, Nishio A, Van de Water J, Ansari AA, Leung PS, Nakanuma Y, Coppel RL, Gershwin ME. Monoclonal antibodies to mitochondrial E2 components define autoepitopes in primary biliary cirrhosis. J Immunol. 1998 Nov 15; 161(10):5157-63. PMID: 9820485.
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    137. Masanaga T, Watanabe Y, Van de Water J, Leung PS, Nakanishi T, Kajiyama G, Ruebner BH, Coppel RL, Gershwin ME. Induction and persistence of immune-mediated cholangiohepatitis in neonatally thymectomized mice. Clin Immunol Immunopathol. 1998 Nov; 89(2):141-9. PMID: 9787116.
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    138. Malmborg AC, Shultz DB, Luton F, Mostov KE, Richly E, Leung PS, Benson GD, Ansari AA, Coppel RL, Gershwin ME, Van de Water J. Penetration and co-localization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis. J Autoimmun. 1998 Oct; 11(5):573-80. PMID: 9802945.
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    139. Mason AL, Xu L, Guo L, Munoz S, Jaspan JB, Bryer-Ash M, Cao Y, Sander DM, Shoenfeld Y, Ahmed A, Van de Water J, Gershwin ME, Garry RF. Detection of retroviral antibodies in primary biliary cirrhosis and other idiopathic biliary disorders. Lancet. 1998 May 30; 351(9116):1620-4. PMID: 9620716.
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    140. Van de Water J, Gershwin ME. And the beat goes on: discovery of "new" autoantigens. Gastroenterology. 1998 Feb; 114(2):400-3. PMID: 9453502.
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    141. Nakanuma Y, Harada K, Kaji K, Terasaki S, Tsuneyama K, Moteki S, Van de Water J, Leung PS, Gershwin ME. Clinicopathological study of primary biliary cirrhosis negative for antimitochondrial antibodies. Liver. 1997 Dec; 17(6):281-7. PMID: 9455733.
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    142. Van de Water J, Deininger SO, Macht M, Przybylski M, Gershwin ME. Detection of molecular determinants and epitope mapping using MALDI-TOF mass spectrometry. Clin Immunol Immunopathol. 1997 Dec; 85(3):229-35. PMID: 9400622.
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    143. Mattalia A, Lüttig B, Rosina F, Leung PS, Van de Water J, Bauducci M, Ciancio A, Böker KH, Worman H, Cooper RL, Manns M, Ansari A, Rizzetto M, Gershwin ME. Persistence of autoantibodies against recombinant mitochondrial and nuclear pore proteins after orthotopic liver transplantation for primary biliary cirrhosis. J Autoimmun. 1997 Oct; 10(5):491-7. PMID: 9376077.
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    144. Nishio A, Van de Water J, Leung PS, Joplin R, Neuberger JM, Lake J, Björkland A, Tötterman TH, Peters M, Worman HJ, Ansari AA, Coppel RL, Gershwin ME. Comparative studies of antimitochondrial autoantibodies in sera and bile in primary biliary cirrhosis. Hepatology. 1997 May; 25(5):1085-9. PMID: 9141421.
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    145. Van de Water J, Shimoda S, Niho Y, Coppel R, Ansari A, Gershwin ME. The role of T cells in primary biliary cirrhosis. Semin Liver Dis. 1997 May; 17(2):105-13. PMID: 9170197.
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    146. Harada K, Van de Water J, Leung PS, Coppel RL, Ansari A, Nakanuma Y, Gershwin ME. In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: predominance of the Th1 subset. Hepatology. 1997 Apr; 25(4):791-6. PMID: 9096578.
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    147. Turchany JM, Uibo R, Kivik T, Van de Water J, Prindiville T, Coppel RL, Gershwin ME. A study of antimitochondrial antibodies in a random population in Estonia. Am J Gastroenterol. 1997 Jan; 92(1):124-6. PMID: 8995951.
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    148. Tsuneyama K, Van De Water J, Yamazaki K, Suzuki K, Sato S, Takeda Y, Ruebner B, Yost BA, Nakanuma Y, Coppel RL, Gershwin ME. Primary biliary cirrhosis an epithelitis: evidence of abnormal salivary gland immunohistochemistry. Autoimmunity. 1997; 26(1):23-31. PMID: 9556352.
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    149. Harada K, Van de Water J, Leung PS, Coppel RL, Nakanuma Y, Gershwin ME. In situ nucleic acid hybridization of pyruvate dehydrogenase complex-E2 in primary biliary cirrhosis: pyruvate dehydrogenase complex-E2 messenger RNA is expressed in hepatocytes but not in biliary epithelium. Hepatology. 1997 Jan; 25(1):27-32. PMID: 8985260.
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    150. Yip TT, Van de Water J, Gershwin ME, Coppel RL, Hutchens TW. Cryptic antigenic determinants on the extracellular pyruvate dehydrogenase complex/mimeotope found in primary biliary cirrhosis. A probe by affinity mass spectrometry. J Biol Chem. 1996 Dec 20; 271(51):32825-33. PMID: 8955120.
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    151. Leung PS, Cha S, Joplin RE, Galperin C, Van de Water J, Ansari AA, Coppel RL, Schatz PJ, Cwirla S, Fabris LE, Neuberger JM, Gershwin ME. Inhibition of PDC-E2 human combinatorial autoantibodies by peptide mimotopes. J Autoimmun. 1996 Dec; 9(6):785-93. PMID: 9115581.
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    152. Van de Water J, Gerson LB, Ferrell LD, Lake JR, Coppel RL, Batts KP, Wiesner RH, Gershwin ME. Immunohistochemical evidence of disease recurrence after liver transplantation for primary biliary cirrhosis. Hepatology. 1996 Nov; 24(5):1079-84. PMID: 8903379.
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    153. Cha S, Leung PS, Van de Water J, Tsuneyama K, Joplin RE, Ansari AA, Nakanuma Y, Schatz PJ, Cwirla S, Fabris LE, Neuberger JM, Gershwin ME, Coppel RL. Random phage mimotopes recognized by monoclonal antibodies against the pyruvate dehydrogenase complex-E2 (PDC-E2). Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):10949-54. PMID: 8855289.
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    154. Hoso M, Nakanuma Y, Kawano M, Oda K, Tsuneyama K, van de Water J, Gershwin ME. Granulomatous cholangitis in chronic hepatitis C: a new diagnostic problem in liver pathology. Pathol Int. 1996 Apr; 46(4):301-5. PMID: 8726856.
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    155. Leung PS, Van de Water J, Coppel RL, Nakanuma Y, Munoz S, Gershwin ME. Molecular aspects and the pathological basis of primary biliary cirrhosis. J Autoimmun. 1996 Apr; 9(2):119-28. PMID: 8738955.
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    156. Tsuneyama K, Van De Water J, Van Thiel D, Coppel R, Ruebner B, Nakanuma Y, Dickson ER, Gershwin ME. Abnormal expression of PDC-E2 on the apical surface of biliary epithelial cells in patients with antimitochondrial antibody-negative primary biliary cirrhosis. Hepatology. 1995 Nov; 22(5):1440-6. PMID: 7590661.
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    157. Duncan MR, Berman B, Van de Water J, Boyd RL, Wick G, Gershwin ME. Mononuclear cells isolated from fibrotic skin lesions in avian scleroderma constitutively produce fibroblast-activating cytokines and immunoglobulin M. Int Arch Allergy Immunol. 1995 Aug; 107(4):519-26. PMID: 7620367.
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    158. Takeoka Y, Yoshida SH, Van de Water J, Boyd R, Suehiro S, Ansari AA, Gershwin ME. Thymic microenvironmental abnormalities in MRL/MP-lpr/lpr, BXSB/MpJ Yaa and C3H HeJ-gld/gld mice. J Autoimmun. 1995 Apr; 8(2):145-61. PMID: 7612145.
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    159. Tsuneyama K, Van de Water J, Leung PS, Cha S, Nakanuma Y, Kaplan M, De Lellis R, Coppel R, Ansari A, Gershwin ME. Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatibility complex class II and BB1/B7 expression. Hepatology. 1995 Apr; 21(4):1031-7. PMID: 7535733.
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    160. Yasoshima M, Nakanuma Y, Tsuneyama K, Van de Water J, Gershwin ME. Immunohistochemical analysis of adhesion molecules in the micro-environment of portal tracts in relation to aberrant expression of PDC-E2 and HLA-DR on the bile ducts in primary biliary cirrhosis. J Pathol. 1995 Mar; 175(3):319-25. PMID: 7538164.
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    161. Van de Water J, Ansari A, Prindiville T, Coppel RL, Ricalton N, Kotzin BL, Liu S, Roche TE, Krams SM, Munoz S, Gershwin ME. Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis. J Exp Med. 1995 Feb 01; 181(2):723-33. PMID: 7836925.
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    162. Nakanuma Y, Tsuneyama K, Kono N, Hoso M, Van de Water J, Gershwin ME. Biliary epithelial expression of pyruvate dehydrogenase complex in primary biliary cirrhosis: an immunohistochemical and immunoelectron microscopic study. Hum Pathol. 1995 Jan; 26(1):92-8. PMID: 7821922.
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    163. Van de Water J, Jimenez SA, Gershwin ME. Animal models of scleroderma: contrasts and comparisons. Int Rev Immunol. 1995; 12(2-4):201-16. PMID: 7544386.
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    164. Kaji K, Nakanuma Y, Sasaki M, Unoura M, Kobayashi K, Nonomura A, Tsuneyama K, Van de Water J, Gershwin ME. Hepatitic bile duct injuries in chronic hepatitis C: histopathologic and immunohistochemical studies. Mod Pathol. 1994 Dec; 7(9):937-45. PMID: 7892163.
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    165. Tsuneyama K, Van de Water J, Nakanuma Y, Cha S, Ansari A, Coppel R, Gershwin ME. Human combinatorial autoantibodies and mouse monoclonal antibodies to PDC-E2 produce abnormal apical staining of salivary glands in patients with coexistent primary biliary cirrhosis and Sjögren's syndrome. Hepatology. 1994 Oct; 20(4 Pt 1):893-8. PMID: 7927231.
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    166. Van De Water J, Gershwin ME. An autoantigen in PSC? Whither or whether? Hepatology. 1994 Oct; 20(4 Pt 1):1096-8. PMID: 7927215.
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    167. Cha S, Leung PS, Coppel RL, Van de Water J, Ansari AA, Gershwin ME. Heterogeneity of combinatorial human autoantibodies against PDC-E2 and biliary epithelial cells in patients with primary biliary cirrhosis. Hepatology. 1994 Sep; 20(3):574-83. PMID: 7521314.
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    168. Begovich AB, Klitz W, Moonsamy PV, Van de Water J, Peltz G, Gershwin ME. Genes within the HLA class II region confer both predisposition and resistance to primary biliary cirrhosis. Tissue Antigens. 1994 Feb; 43(2):71-7. PMID: 8016844.
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    169. Van de Water J, Boyd R, Wick G, Gershwin ME. The immunologic and genetic basis of avian scleroderma, an inherited fibrotic disease of line 200 chickens. Int Rev Immunol. 1994; 11(3):273-82. PMID: 7930849.
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    170. Van de Water J, Gershwin ME. Primary biliary cirrhosis: cells, sera, and soluble factors. Mayo Clin Proc. 1993 Nov; 68(11):1128-30. PMID: 8231281.
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    171. Van de Water J, Turchany J, Leung PS, Lake J, Munoz S, Surh CD, Coppel R, Ansari A, Nakanuma Y, Gershwin ME. Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2. J Clin Invest. 1993 Jun; 91(6):2653-64. PMID: 8514873.
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    172. Duncan MR, Wilson TJ, Van De Water J, Berman B, Boyd R, Wick G, Gershwin ME. Cultured fibroblasts in avian scleroderma, an autoimmune fibrotic disease, display an activated phenotype. J Autoimmun. 1992 Oct; 5(5):603-15. PMID: 1418297.
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    173. Wilson TJ, Van de Water J, Mohr FC, Boyd RL, Ansari A, Wick G, Gershwin ME. Avian scleroderma: evidence for qualitative and quantitative T cell defects. J Autoimmun. 1992 Jun; 5(3):261-76. PMID: 1388634.
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    174. Halpern GM, Van de Water J, Delabroise AM, Keen CL, Gershwin ME. Comparative uptake of calcium from milk and a calcium-rich mineral water in lactose intolerant adults: implications for treatment of osteoporosis. Am J Prev Med. 1991 Nov-Dec; 7(6):379-83. PMID: 1790046.
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    175. Wilson TJ, Van de Water J, Boyd RL, Abplanalp H, Gershwin ME. Abnormalities associated with the bursal microenvironment in spontaneous dysgammaglobulinemia of UCD line 140 chickens. Clin Immunol Immunopathol. 1991 May; 59(2):208-21. PMID: 2009641.
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    176. Boyd RL, Wilson TJ, Van De Water J, Haapanen LA, Gershwin ME. Selective abnormalities in the thymic microenvironment associated with avian scleroderma, an inherited fibrotic disease of L200 chickens. J Autoimmun. 1991 Apr; 4(2):369-80. PMID: 1883483.
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    177. Leung PS, Van de Water J, Coppel RL, Gershwin ME. Molecular characterization of the mitochondrial autoantigens in primary biliary cirrhosis. Immunol Res. 1991; 10(3-4):518-27. PMID: 1720161.
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    178. Van de Water J, Ansari AA, Surh CD, Coppel R, Roche T, Bonkovsky H, Kaplan M, Gershwin ME. Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis. J Immunol. 1991 Jan 01; 146(1):89-94. PMID: 1984455.
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    179. Krams SM, Van de Water J, Coppel RL, Esquivel C, Roberts J, Ansari A, Gershwin ME. Analysis of hepatic T lymphocyte and immunoglobulin deposits in patients with primary biliary cirrhosis. Hepatology. 1990 Aug; 12(2):306-13. PMID: 2202637.
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    180. Van de Water J, Wilson TJ, Haapanen LA, Boyd RL, Abplanalp H, Gershwin ME. Ontogeny of T cell development in avian scleroderma. Clin Immunol Immunopathol. 1990 Aug; 56(2):169-84. PMID: 2143126.
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    181. van de Water J, Haapanen L, Boyd R, Abplanalp H, Gershwin ME. Identification of T cells in early dermal lymphocytic infiltrates in avian scleroderma. Arthritis Rheum. 1989 Aug; 32(8):1031-40. PMID: 2669767.
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    182. Van de Water J, Cooper A, Surh CD, Coppel R, Danner D, Ansari A, Dickson R, Gershwin ME. Detection of autoantibodies to recombinant mitochondrial proteins in patients with primary biliary cirrhosis. N Engl J Med. 1989 May 25; 320(21):1377-80. PMID: 2716784.
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    183. Van de Water J, Surh CD, Leung PS, Krams SM, Fregeau D, Davis P, Coppel R, Mackay IR, Gershwin ME. Molecular definitions, autoepitopes, and enzymatic activities of the mitochondrial autoantigens of primary biliary cirrhosis. Semin Liver Dis. 1989 May; 9(2):132-7. PMID: 2471277.
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    184. Van de Water J, Fregeau D, Davis P, Ansari A, Danner D, Leung P, Coppel R, Gershwin ME. Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function. J Immunol. 1988 Oct 01; 141(7):2321-4. PMID: 3049806.
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    185. Coppel RL, McNeilage LJ, Surh CD, Van de Water J, Spithill TW, Whittingham S, Gershwin ME. Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7317-21. PMID: 3174635.
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    186. Van de Water J, Gershwin ME, Leung P, Ansari A, Coppel RL. The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase. J Exp Med. 1988 Jun 01; 167(6):1791-9. PMID: 2455013.
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    187. van de Water J, Gershwin ME. Animal model of human disease. Avian scleroderma. An inherited fibrotic disease of white Leghorn chickens resembling progressive systemic sclerosis. Am J Pathol. 1985 Sep; 120(3):478-82. PMID: 4037069.
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    188. Van de Water J, Gershwin ME, Benedict AA, Abplanalp H. Inherited dysgammaglobulinemia of chickens: reduced incidence of disease in parabiotic chimeras. Clin Immunol Immunopathol. 1985 Jul; 36(1):1-9. PMID: 4006321.
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    189. van de Water J, Gershwin ME, Abplanalp H, Wick G, von der Mark K. Serial observations and definition of mononuclear cell infiltrates in avian scleroderma, an inherited fibrotic disease of chickens. Arthritis Rheum. 1984 Jul; 27(7):807-15. PMID: 6743362.
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