Scott Simon

Title(s)Professor, Biomedical Engineering
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bailey KA, Haj FG, Simon SI, Passerini AG. Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. Sci Rep. 2017 Aug 15; 7(1):8196. PMID: 28811527.
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    2. Morikis VA, Chase S, Wun T, Chaikof EL, Magnani JL, Simon SI. Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow. Blood. 2017 11 09; 130(19):2101-2110. PMID: 28811304.
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    3. Falahee PC, Anderson LS, Reynolds MB, Pirir M, McLaughlin BE, Dillen CA, Cheung AL, Miller LS, Simon SI. a-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds. J Immunol. 2017 09 01; 199(5):1772-1782. PMID: 28733486.
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    4. Murphy KC, Whitehead J, Falahee PC, Zhou D, Simon SI, Leach JK. Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids. Stem Cells. 2017 06; 35(6):1493-1504. PMID: 28276602.
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    5. Simon SI, Mikos AG, McIntire LV. Fond Memories of our Mentor J. David Hellums, Annals of Biomedical Engineering. Ann Biomed Eng. 2016 11; 44(11):3157. PMID: 27783234.
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    6. Morikis VA, Radecke C, Jiang Y, Heinrich V, Curry FR, Simon SI. Atrial natriuretic peptide down-regulates neutrophil recruitment on inflamed endothelium by reducing cell deformability and resistance to detachment force. Biorheology. 2016 07 04; 53(2):109. PMID: 27392827.
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    7. Waffarn EE, Hastey CJ, Dixit N, Soo Choi Y, Cherry S, Kalinke U, Simon SI, Baumgarth N. Infection-induced type I interferons activate CD11b on B-1 cells for subsequent lymph node accumulation. Nat Commun. 2015 Nov 27; 6:8991. PMID: 26612263; PMCID: PMC4896500.
    8. Foster GA, Xu L, Chidambaram AA, Soderberg SR, Armstrong EJ, Wu H, Simon SI. CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia. J Immunol. 2015 Dec 01; 195(11):5380-92. PMID: 26519532; PMCID: PMC4655135 [Available on 12/01/16].
    9. Block H, Stadtmann A, Riad D, Rossaint J, Sohlbach C, Germena G, Wu D, Simon SI, Ley K, Zarbock A. Gnb isoforms control a signaling pathway comprising Rac1, Plcß2, and Plcß3 leading to LFA-1 activation and neutrophil arrest in vivo. Blood. 2016 Jan 21; 127(3):314-24. PMID: 26468229; PMCID: PMC4722285 [Available on 01/21/17].
    10. Xu L, Dai Perrard X, Perrard JL, Yang D, Xiao X, Teng BB, Simon SI, Ballantyne CM, Wu H. Foamy monocytes form early and contribute to nascent atherosclerosis in mice with hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2015 Aug; 35(8):1787-97. PMID: 26112011; PMCID: PMC4514542.
    11. Krishnamurthy VR, Sardar MY, Ying Y, Song X, Haller C, Dai E, Wang X, Hanjaya-Putra D, Sun L, Morikis V, Simon SI, Woods RJ, Cummings RD, Chaikof EL. Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo. Nat Commun. 2015 Mar 31; 6:6387. PMID: 25824568; PMCID: PMC4423566.
    12. Morikis VA, Radecke C, Jiang Y, Heinrich V, Curry FR, Simon SI. Atrial natriuretic peptide down-regulates neutrophil recruitment on inflamed endothelium by reducing cell deformability and resistance to detachment force. Biorheology. 2015; 52(5-6):447-63. PMID: 26639357; PMCID: PMC5019877.
    13. Tarbell JM, Simon SI, Curry FR. Mechanosensing at the vascular interface. Annu Rev Biomed Eng. 2014 Jul 11; 16:505-32. PMID: 24905872; PMCID: PMC4450720.
    14. Altman SM, Dixit N, Simon SI. Detection of bidirectional signaling during integrin activation and neutrophil adhesion. Methods Mol Biol. 2014; 1124:235-48. PMID: 24504956; PMCID: PMC4438672.
    15. Wang YI, Bettaieb A, Sun C, DeVerse JS, Radecke CE, Mathew S, Edwards CM, Haj FG, Passerini AG, Simon SI. Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential regulation of endoplasmic reticulum stress. PLoS One. 2013; 8(10):e78322. PMID: 24205197; PMCID: PMC3804477.
    16. Kim MH, Gorouhi F, Ramirez S, Granick JL, Byrne BA, Soulika AM, Simon SI, Rivkah Isseroff R. Catecholamine stress alters neutrophil trafficking and impairs wound healing by ß2-adrenergic receptor-mediated upregulation of IL-6. J Invest Dermatol. 2014 Mar; 134(3):809-817. PMID: 24121404; PMCID: PMC4013292.
    17. Simon SI. Clocking leukocytes reveal dynamics of integrin braking. Biophys J. 2013 Sep 03; 105(5):1091-2. PMID: 24010651; PMCID: PMC3762342.
    18. DeVerse JS, Sandhu AS, Mendoza N, Edwards CM, Sun C, Simon SI, Passerini AG. Shear stress modulates VCAM-1 expression in response to TNF-a and dietary lipids via interferon regulatory factor-1 in cultured endothelium. Am J Physiol Heart Circ Physiol. 2013 Oct 15; 305(8):H1149-57. PMID: 23934855; PMCID: PMC3798784.
    19. Foster GA, Gower RM, Stanhope KL, Havel PJ, Simon SI, Armstrong EJ. On-chip phenotypic analysis of inflammatory monocytes in atherogenesis and myocardial infarction. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13944-9. PMID: 23918401.
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    20. Ober H, Simon SI, Elson D. Five simple rules to avoid plagiarism. Ann Biomed Eng. 2013 Jan; 41(1):1-2. PMID: 23053297.
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    21. Kim MH, Yamayoshi I, Mathew S, Lin H, Nayfach J, Simon SI. Magnetic nanoparticle targeted hyperthermia of cutaneous Staphylococcus aureus infection. Ann Biomed Eng. 2013 Mar; 41(3):598-609. PMID: 23149904; PMCID: PMC3740557.
    22. Dixit N, Kim MH, Rossaint J, Yamayoshi I, Zarbock A, Simon SI. Leukocyte function antigen-1, kindlin-3, and calcium flux orchestrate neutrophil recruitment during inflammation. J Immunol. 2012 Dec 15; 189(12):5954-64. PMID: 23144497; PMCID: PMC3723394.
    23. Sun C, Alkhoury K, Wang YI, Foster GA, Radecke CE, Tam K, Edwards CM, Facciotti MT, Armstrong EJ, Knowlton AA, Newman JW, Passerini AG, Simon SI. IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal. Circ Res. 2012 Sep 28; 111(8):1054-64. PMID: 22874466; PMCID: PMC3810165.
    24. Kusunose J, Zhang H, Gagnon MK, Pan T, Simon SI, Ferrara KW. Microfluidic system for facilitated quantification of nanoparticle accumulation to cells under laminar flow. Ann Biomed Eng. 2013 Jan; 41(1):89-99. PMID: 22855121; PMCID: PMC3505813.
    25. DeVerse JS, Bailey KA, Foster GA, Mittal V, Altman SM, Simon SI, Passerini AG. On-chip endothelial inflammatory phenotyping. J Vis Exp. 2012 Jul 21; (65):e4169. PMID: 22847646; PMCID: PMC3476418.
    26. Dixit N, Simon SI. Chemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrest. Front Immunol. 2012; 3:188. PMID: 22787461; PMCID: PMC3392659.
    27. Granick JL, Simon SI, Borjesson DL. Hematopoietic stem and progenitor cells as effectors in innate immunity. Bone Marrow Res. 2012; 2012:165107. PMID: 22762001; PMCID: PMC3385697.
    28. Davis BB, Liu JY, Tancredi DJ, Wang L, Simon SI, Hammock BD, Pinkerton KE. The anti-inflammatory effects of soluble epoxide hydrolase inhibitors are independent of leukocyte recruitment. Biochem Biophys Res Commun. 2011 Jul 08; 410(3):494-500. PMID: 21683067; PMCID: PMC3166856.
    29. Dixit N, Yamayoshi I, Nazarian A, Simon SI. Migrational guidance of neutrophils is mechanotransduced via high-affinity LFA-1 and calcium flux. J Immunol. 2011 Jul 01; 187(1):472-81. PMID: 21632714; PMCID: PMC3414252.
    30. Kim MH, Granick JL, Kwok C, Walker NJ, Borjesson DL, Curry FR, Miller LS, Simon SI. Neutrophil survival and c-kit(+)-progenitor proliferation in Staphylococcus aureus-infected skin wounds promote resolution. Blood. 2011 Mar 24; 117(12):3343-52. PMID: 21278352; PMCID: PMC3069674.
    31. Wang YI, Schulze J, Raymond N, Tomita T, Tam K, Simon SI, Passerini AG. Endothelial inflammation correlates with subject triglycerides and waist size after a high-fat meal. Am J Physiol Heart Circ Physiol. 2011 Mar; 300(3):H784-91. PMID: 21169396; PMCID: PMC3064298.
    32. Gower RM, Wu H, Foster GA, Devaraj S, Jialal I, Ballantyne CM, Knowlton AA, Simon SI. CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):160-6. PMID: 21030716; PMCID: PMC3038249.
    33. Schaff UY, Dixit N, Procyk E, Yamayoshi I, Tse T, Simon SI. Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow. Blood. 2010 Jan 21; 115(3):657-66. PMID: 19965684; PMCID: PMC2810981.
    34. Phillipson M, Heit B, Parsons SA, Petri B, Mullaly SC, Colarusso P, Gower RM, Neely G, Simon SI, Kubes P. Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculature. J Immunol. 2009 Jun 01; 182(11):6870-8. PMID: 19454683; PMCID: PMC4017595.
    35. Wu H, Gower RM, Wang H, Perrard XY, Ma R, Bullard DC, Burns AR, Paul A, Smith CW, Simon SI, Ballantyne CM. Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia. Circulation. 2009 May 26; 119(20):2708-17. PMID: 19433759; PMCID: PMC2716173.
    36. Kim MH, Curry FR, Simon SI. Dynamics of neutrophil extravasation and vascular permeability are uncoupled during aseptic cutaneous wounding. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C848-56. PMID: 19176758; PMCID: PMC2670654.
    37. Sarantos MR, Zhang H, Schaff UY, Dixit N, Hayenga HN, Lowell CA, Simon SI. Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase. J Immunol. 2008 Dec 15; 181(12):8660-9. PMID: 19050286; PMCID: PMC4457456.
    38. Simon SI, Sarantos MR, Green CE, Schaff UY. Leucocyte recruitment under fluid shear: mechanical and molecular regulation within the inflammatory synapse. Clin Exp Pharmacol Physiol. 2009 Feb; 36(2):217-24. PMID: 19018799.
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    39. Tsou JK, Gower RM, Ting HJ, Schaff UY, Insana MF, Passerini AG, Simon SI. Spatial regulation of inflammation by human aortic endothelial cells in a linear gradient of shear stress. Microcirculation. 2008 May; 15(4):311-23. PMID: 18464160; PMCID: PMC2733907.
    40. Zhang Y, Hayenga HN, Sarantos MR, Simon SI, Neelamegham S. Differential regulation of neutrophil CD18 integrin function by di- and tri-valent cations: manganese vs. gadolinium. Ann Biomed Eng. 2008 Apr; 36(4):647-60. PMID: 18317931.
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    41. Schaff UY, Yamayoshi I, Tse T, Griffin D, Kibathi L, Simon SI. Calcium flux in neutrophils synchronizes beta2 integrin adhesive and signaling events that guide inflammatory recruitment. Ann Biomed Eng. 2008 Apr; 36(4):632-46. PMID: 18278555; PMCID: PMC2668576.
    42. Liang S, Slattery MJ, Wagner D, Simon SI, Dong C. Hydrodynamic shear rate regulates melanoma-leukocyte aggregation, melanoma adhesion to the endothelium, and subsequent extravasation. Ann Biomed Eng. 2008 Apr; 36(4):661-71. PMID: 18253835; PMCID: PMC2677444.
    43. Shin HY, Simon SI, Schmid-Schönbein GW. Fluid shear-induced activation and cleavage of CD18 during pseudopod retraction by human neutrophils. J Cell Physiol. 2008 Feb; 214(2):528-36. PMID: 17676580.
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    44. Schaff UY, Shih HH, Lorenz M, Sako D, Kriz R, Milarski K, Bates B, Tchernychev B, Shaw GD, Simon SI. SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1. Eur J Immunol. 2008 Feb; 38(2):550-64. PMID: 18196517; PMCID: PMC3414251.
    45. Kim MH, Liu W, Borjesson DL, Curry FR, Miller LS, Cheung AL, Liu FT, Isseroff RR, Simon SI. Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging. J Invest Dermatol. 2008 Jul; 128(7):1812-20. PMID: 18185533; PMCID: PMC2617712.
    46. Schaff U, Mattila PE, Simon SI, Walcheck B. Neutrophil adhesion to E-selectin under shear promotes the redistribution and co-clustering of ADAM17 and its proteolytic substrate L-selectin. J Leukoc Biol. 2008 Jan; 83(1):99-105. PMID: 17928459.
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    47. Sadhu C, Ting HJ, Lipsky B, Hensley K, Garcia-Martinez LF, Simon SI, Staunton DE. CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity. J Leukoc Biol. 2007 Jun; 81(6):1395-403. PMID: 17389580.
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    48. Tsourkas PK, Baumgarth N, Simon SI, Raychaudhuri S. Mechanisms of B-cell synapse formation predicted by Monte Carlo simulation. Biophys J. 2007 Jun 15; 92(12):4196-208. PMID: 17384077.
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    49. Simon SI, Nyunt T, Florine-Casteel K, Ritchie K, Ting-Beall HP, Evans E, Needham D. Dynamics of neutrophil membrane compliance and microstructure probed with a micropipet-based piconewton force transducer. Ann Biomed Eng. 2007 Apr; 35(4):595-604. PMID: 17370125.
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    50. Schaff UY, Xing MM, Lin KK, Pan N, Jeon NL, Simon SI. Vascular mimetics based on microfluidics for imaging the leukocyte--endothelial inflammatory response. Lab Chip. 2007 Apr; 7(4):448-56. PMID: 17389960.
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    51. Ting HJ, Stice JP, Schaff UY, Hui DY, Rutledge JC, Knowlton AA, Passerini AG, Simon SI. Triglyceride-rich lipoproteins prime aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-alpha. Circ Res. 2007 Feb 16; 100(3):381-90. PMID: 17234968.
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    52. Schaff UY, Sarantos MR, Ting H, Simon SI. Optical and fluorescence detection of neutrophil integrin activation. Methods Mol Biol. 2007; 412:203-10. PMID: 18453113.
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    53. Zhang H, Schaff UY, Green CE, Chen H, Sarantos MR, Hu Y, Wara D, Simon SI, Lowell CA. Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils. Immunity. 2006 Aug; 25(2):285-95. PMID: 16901726; PMCID: PMC4698343.
    54. Borden MA, Sarantos MR, Stieger SM, Simon SI, Ferrara KW, Dayton PA. Ultrasound radiation force modulates ligand availability on targeted contrast agents. Mol Imaging. 2006 Jul; 5(3):139-47. PMID: 16954028; PMCID: PMC1636845.
    55. Devaraj S, Davis B, Simon SI, Jialal I. CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions. Am J Physiol Heart Circ Physiol. 2006 Sep; 291(3):H1170-6. PMID: 16603696.
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    56. Lum AF, Borden MA, Dayton PA, Kruse DE, Simon SI, Ferrara KW. Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles. J Control Release. 2006 Mar 10; 111(1-2):128-34. PMID: 16380187; PMCID: PMC1526414.
    57. Green CE, Schaff UY, Sarantos MR, Lum AF, Staunton DE, Simon SI. Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium. Blood. 2006 Mar 01; 107(5):2101-11. PMID: 16269618; PMCID: PMC1895714.
    58. Sarantos MR, Raychaudhuri S, Lum AF, Staunton DE, Simon SI. Leukocyte function-associated antigen 1-mediated adhesion stability is dynamically regulated through affinity and valency during bond formation with intercellular adhesion molecule-1. J Biol Chem. 2005 Aug 05; 280(31):28290-8. PMID: 15955822.
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    59. Mattila PE, Green CE, Schaff U, Simon SI, Walcheck B. Cytoskeletal interactions regulate inducible L-selectin clustering. Am J Physiol Cell Physiol. 2005 Aug; 289(2):C323-32. PMID: 15788481.
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    60. King MR, Sumagin R, Green CE, Simon SI. Rolling dynamics of a neutrophil with redistributed L-selectin. Math Biosci. 2005 Mar; 194(1):71-9. PMID: 15836865.
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    61. Simon SI, Green CE. Molecular mechanics and dynamics of leukocyte recruitment during inflammation. Annu Rev Biomed Eng. 2005; 7:151-85. PMID: 16004569.
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    62. McDonough DB, McIntosh FA, Spanos C, Neelamegham S, Goldsmith HL, Simon SI. Cooperativity between selectins and beta2-integrins define neutrophil capture and stable adhesion in shear flow. Ann Biomed Eng. 2004 Sep; 32(9):1179-92. PMID: 15493506.
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    63. Green CE, Pearson DN, Camphausen RT, Staunton DE, Simon SI. Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils. J Immunol. 2004 Jun 15; 172(12):7780-90. PMID: 15187162.
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    64. Lum AF, Wun T, Staunton D, Simon SI. Inflammatory potential of neutrophils detected in sickle cell disease. Am J Hematol. 2004 Jun; 76(2):126-33. PMID: 15164377.
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    65. Borjesson DL, Simon SI, Hodzic E, DeCock HE, Ballantyne CM, Barthold SW. Roles of neutrophil beta 2 integrins in kinetics of bacteremia, extravasation, and tick acquisition of Anaplasma phagocytophila in mice. Blood. 2003 Apr 15; 101(8):3257-64. PMID: 12480703.
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    66. Green CE, Pearson DN, Christensen NB, Simon SI. Topographic requirements and dynamics of signaling via L-selectin on neutrophils. Am J Physiol Cell Physiol. 2003 Mar; 284(3):C705-17. PMID: 12431911.
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    67. Hentzen E, McDonough D, McIntire L, Smith CW, Goldsmith HL, Simon SI. Hydrodynamic shear and tethering through E-selectin signals phosphorylation of p38 MAP kinase and adhesion of human neutrophils. Ann Biomed Eng. 2002 Sep; 30(8):987-1001. PMID: 12449760.
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    68. Lum AF, Green CE, Lee GR, Staunton DE, Simon SI. Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow. J Biol Chem. 2002 Jun 07; 277(23):20660-70. PMID: 11929876.
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    69. Simon SI, Goldsmith HL. Leukocyte adhesion dynamics in shear flow. Ann Biomed Eng. 2002 Mar; 30(3):315-32. PMID: 12051617.
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    70. Borjesson DL, Simon SI, Hodzic E, Ballantyne CM, Barthold SW. Kinetics of CD11b/CD18 up-regulation during infection with the agent of human granulocytic ehrlichiosis in mice. Lab Invest. 2002 Mar; 82(3):303-11. PMID: 11896209.
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    71. Simon SI, Hu Y, Vestweber D, Smith CW. Neutrophil tethering on E-selectin activates beta 2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathway. J Immunol. 2000 Apr 15; 164(8):4348-58. PMID: 10754335.
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