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Stephen J McSorley

TitlePROF-SFT-VM
InstitutionUniversity of California Davis
DepartmentVM: ANAT PHYSIO & CELL BIOLOGY
AddressCounty Rd 98 at Hutchison Drive
CA 95616
Phone530-752-3414
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    Collapse Research 
    Collapse Research Activities and Funding
    Target antigen identification to improve Salmonella vaccination
    NIH/NIAID R01AI139410Jun 1, 2018 - May 31, 2023
    Role: Principal Investigator
    A model to visualize CD4 T cell responses to non-pathogenic E. coli
    NIH/NIAID R21AI125228Jun 9, 2017 - May 31, 2019
    Role: Principal Investigator
    CD4 T cell responses to Chlamydia infection
    NIH/NIAID R01AI103422Mar 1, 2016 - Feb 29, 2020
    Role: Principal Investigator
    Generation of a TCR transgenic mouse to study Chlamydia genital tract infection
    NIH/NIAID R21AI117303Feb 1, 2015 - Jan 31, 2017
    Role: Principal Investigator
    Modulation of Erythropoiesis During Salmonella Infection
    NIH/NHLBI R21HL112685Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Typhoid priority antigen identification and vaccine development
    NIH/NIAID R01AI073672Aug 20, 2008 - Jul 31, 2013
    Role: Principal Investigator
    Innate immune response to bacterial flagellins
    NIH/NIAID R01AI076278Dec 1, 2007 - Jul 31, 2016
    Role: Principal Investigator
    CD4 T cell responses to Salmonella
    NIH/NIAID R01AI055743Jul 1, 2003 - Feb 28, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Withers SS, Moore PF, Chang H, Choi JW, McSorley S, Kent MS, Monjazeb AM, Canter RJ, Murphy WJ, Sparger EE, Rebhun RB. Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs. Dev Comp Immunol. 2018 May 31; 87:64-74. PMID: 29859828.
      View in: PubMed
    2. Pham OH, O'Donnell H, Al-Shamkhani A, Kerrinnes T, Tsolis RM, McSorley S. T cell expression of IL-18R and DR3 is essential for non-cognate stimulation of Th1 cells and optimal clearance of intracellular bacteria. PLoS Pathog. 2017 Aug; 13(8):e1006566. PMID: 28817719.
      View in: PubMed
    3. Lee SJ, Benoun J, Sheridan BS, Fogassy Z, Pham O, Pham QM, Puddington L, McSorley S. Dual Immunization with SseB/Flagellin Provides Enhanced Protection against Salmonella Infection Mediated by Circulating Memory Cells. J Immunol. 2017 08 15; 199(4):1353-1361. PMID: 28710253.
      View in: PubMed
    4. Benoun JM, Labuda JC, McSorley S. Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory. MBio. 2016 12 20; 7(6). PMID: 27999159.
      View in: PubMed
    5. Li LX, Benoun JM, Weiskopf K, Garcia KC, McSorley S. Salmonella Infection Enhances Erythropoietin Production by the Kidney and Liver, Which Correlates with Elevated Bacterial Burdens. Infect Immun. 2016 10; 84(10):2833-41. PMID: 27456828.
      View in: PubMed
    6. Keestra-Gounder AM, Byndloss MX, Seyffert N, Young BM, Chávez-Arroyo A, Tsai AY, Cevallos SA, Winter MG, Pham OH, Tiffany CR, de Jong MF, Kerrinnes T, Ravindran R, Luciw PA, McSorley S, Bäumler AJ, Tsolis RM. NOD1 and NOD2 signalling links ER stress with inflammation. Nature. 2016 Apr 21; 532(7599):394-7. PMID: 27007849.
      View in: PubMed
    7. O'Donnell H, Pham OH, Benoun JM, Ravesloot-Chávez MM, McSorley S. Contaminated water delivery as a simple and effective method of experimental Salmonella infection. Future Microbiol. 2015; 10(10):1615-27. PMID: 26439708; PMCID: PMC4942118.
    8. Li LX, McSorley S. A re-evaluation of the role of B cells in protective immunity to Chlamydia infection. Immunol Lett. 2015 Apr; 164(2):88-93. PMID: 25704502; PMCID: PMC4402208.
    9. Pham OH, McSorley S. Protective host immune responses to Salmonella infection. Future Microbiol. 2015; 10(1):101-10. PMID: 25598340; PMCID: PMC4323267.
    10. O'Donnell H, McSorley S. Salmonella as a model for non-cognate Th1 cell stimulation. Front Immunol. 2014; 5:621. PMID: 25540644; PMCID: PMC4261815.
    11. Atif SM, Lee SJ, Li LX, Uematsu S, Akira S, Gorjestani S, Lin X, Schweighoffer E, Tybulewicz VL, McSorley S. Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9. Eur J Immunol. 2015 Feb; 45(2):513-24. PMID: 25430631; PMCID: PMC4324162.
    12. Nanton MR, Lee SJ, Atif SM, Nuccio SP, Taylor JJ, Bäumler AJ, Way SS, McSorley S. Direct visualization of endogenous Salmonella-specific B cells reveals a marked delay in clonal expansion and germinal center development. Eur J Immunol. 2015 Feb; 45(2):428-41. PMID: 25346524; PMCID: PMC4323875.
    13. McSorley S, Khoruts A. Introduction to special issue on microbiome influences on host immunity. Immunol Lett. 2014 Dec; 162(2 Pt A):1-2. PMID: 25124961.
      View in: PubMed
    14. McSorley S. The Role of Non-Cognate T Cell Stimulation during Intracellular Bacterial Infection. Front Immunol. 2014; 5:319. PMID: 25071779; PMCID: PMC4089505.
    15. McSorley S. Immunity to intestinal pathogens: lessons learned from Salmonella. Immunol Rev. 2014 Jul; 260(1):168-82. PMID: 24942689; PMCID: PMC4066191.
    16. Atif SM, Winter SE, Winter MG, McSorley S, Bäumler AJ. Salmonella enterica serovar Typhi impairs CD4 T cell responses by reducing antigen availability. Infect Immun. 2014 Jun; 82(6):2247-54. PMID: 24643532; PMCID: PMC4019166.
    17. O'Donnell H, Pham OH, Li LX, Atif SM, Lee SJ, Ravesloot MM, Stolfi JL, Nuccio SP, Broz P, Monack DM, Baumler AJ, McSorley S. Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells. Immunity. 2014 Feb 20; 40(2):213-24. PMID: 24508233; PMCID: PMC3960852.
    18. Li LX, McSorley S. B cells enhance antigen-specific CD4 T cell priming and prevent bacteria dissemination following Chlamydia muridarum genital tract infection. PLoS Pathog. 2013 Oct; 9(10):e1003707. PMID: 24204262; PMCID: PMC3814678.
    19. Lee SJ, Dunmire S, McSorley S. MHC class-I-restricted CD8 T cells play a protective role during primary Salmonella infection. Immunol Lett. 2012 Dec 17; 148(2):138-43. PMID: 23089550; PMCID: PMC3540194.
    20. Li LX, Atif SM, Schmiel SE, Lee SJ, McSorley S. Increased susceptibility to Salmonella infection in signal regulatory protein a-deficient mice. J Immunol. 2012 Sep 01; 189(5):2537-44. PMID: 22851710; PMCID: PMC3424330.
    21. Gardner MB, Baumgarth N, Fell A, McSorley S, Solnick JV, Bevins CL. Meeting report: a symposium on the evolution of common molecular pathways underlying innate immunity. Microbes Infect. 2012 Aug; 14(9):667-71. PMID: 22580093.
      View in: PubMed
    22. Lee SJ, Liang L, Juarez S, Nanton MR, Gondwe EN, Msefula CL, Kayala MA, Necchi F, Heath JN, Hart P, Tsolis RM, Heyderman RS, MacLennan CA, Felgner PL, Davies DH, McSorley S. Identification of a common immune signature in murine and human systemic Salmonellosis. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4998-5003. PMID: 22331879; PMCID: PMC3324033.
    23. Lee SJ, McLachlan JB, Kurtz JR, Fan D, Winter SE, Baumler AJ, Jenkins MK, McSorley S. Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development. PLoS Pathog. 2012 Jan; 8(1):e1002499. PMID: 22275869; PMCID: PMC3262010.
    24. Jerke S, Srinivasan A, McSorley S. Expression of Toll/IL-1R domain-containing adaptor protein (TIRAP) is detrimental to primary clearance of Salmonella and is not required for the generation of protective immunity. Immunol Lett. 2008 Feb 15; 116(1):64-71. PMID: 18096248; PMCID: PMC2263078.
    25. Salazar-Gonzalez RM, McSorley S. Salmonella flagellin, a microbial target of the innate and adaptive immune system. Immunol Lett. 2005 Nov 15; 101(2):117-22. PMID: 15975666.
      View in: PubMed