Stephen J McSorley

Title(s)Professor, School of Veterinary Medicine
SchoolSchool of Veterinary Medicine
AddressCounty Rd 98 at Hutchison Drive
CA 95616
Phone530-752-3414
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    Collapse Research 
    Collapse Research Activities and Funding
    Salmonella-specific Th1 cell function and residence
    NIH/NIAID R01AI139047Jan 10, 2019 - Dec 31, 2023
    Role: Principal Investigator
    Target antigen identification to improve Salmonella vaccination
    NIH/NIAID R01AI139410Jun 1, 2018 - May 31, 2023
    Role: Principal Investigator
    A model to visualize CD4 T cell responses to non-pathogenic E. coli
    NIH/NIAID R21AI125228Jun 9, 2017 - May 31, 2019
    Role: Principal Investigator
    CD4 T cell responses to Chlamydia infection
    NIH/NIAID R01AI103422Mar 1, 2016 - Feb 29, 2020
    Role: Principal Investigator
    Generation of a TCR transgenic mouse to study Chlamydia genital tract infection
    NIH/NIAID R21AI117303Feb 1, 2015 - Jan 31, 2017
    Role: Principal Investigator
    Modulation of Erythropoiesis During Salmonella Infection
    NIH/NHLBI R21HL112685Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Typhoid priority antigen identification and vaccine development
    NIH/NIAID R01AI073672Aug 20, 2008 - Jul 31, 2013
    Role: Principal Investigator
    Innate immune response to bacterial flagellins
    NIH/NIAID R01AI076278Dec 1, 2007 - Jul 31, 2016
    Role: Principal Investigator
    CD4 T cell responses to Salmonella
    NIH/NIAID R01AI055743Jul 1, 2003 - Feb 28, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice. Nat Microbiol. 2024 Feb 19. Lokken-Toyli KL, Diaz-Ochoa VE, Camacho L, Stull-Lane AR, Van Hecke AER, Mooney JP, Muñoz AD, Walker GT, Hampel D, Jiang X, Labuda JC, Depew CE, McSorley SJ, Stephensen CB, Tsolis RM. PMID: 38374245.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Elimination of Chlamydia muridarum from the female reproductive tract is IL-12p40 dependent, but independent of Th1 and Th2 cells. PLoS Pathog. 2024 Jan; 20(1):e1011914. Rixon JA, Fong KD, Morris C, Nguyen AT, Depew CE, McSorley SJ. PMID: 38166152; PMCID: PMC10786385.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. The role of tissue resident memory CD4 T cells in Salmonella infection: Implications for future vaccines. Vaccine. 2023 Oct 13; 41(43):6426-6433. Depew CE, McSorley SJ. PMID: 37739887.
      View in: PubMed   Mentions:    Fields:    
    4. Cutting Edge: Optimal Formation of Hepatic Tissue-Resident Memory CD4 T Cells Requires T-bet Regulation of CD18. J Immunol. 2023 07 15; 211(2):180-185. Depew CE, Nguyen AT, Franke MC, Calderon J, Sciammas R, McSorley SJ. PMID: 37283516; PMCID: PMC10330511.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Optimal generation of hepatic tissue-resident memory CD4 T cells requires IL-1 and IL-2. Proc Natl Acad Sci U S A. 2023 04 18; 120(16):e2214699120. Depew CE, Rixon JA, McSorley SJ. PMID: 37040404; PMCID: PMC10120061.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. Host cells subdivide nutrient niches into discrete biogeographical microhabitats for gut microbes. Cell Host Microbe. 2022 06 08; 30(6):836-847.e6. Liou MJ, Miller BM, Litvak Y, Nguyen H, Natwick DE, Savage HP, Rixon JA, Mahan SP, Hiyoshi H, Rogers AWL, Velazquez EM, Butler BP, Collins SR, McSorley SJ, Harshey RM, Byndloss MX, Simon SI, Bäumler AJ. PMID: 35568027; PMCID: PMC9187619.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    7. Cohousing with Dirty Mice Increases the Frequency of Memory T Cells and Has Variable Effects on Intracellular Bacterial Infection. Immunohorizons. 2022 02 24; 6(2):184-190. Labuda JC, Fong KD, McSorley SJ. PMID: 35210292; PMCID: PMC9624231.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    8. Th1 cells are dispensable for primary clearance of Chlamydia from the female reproductive tract of mice. PLoS Pathog. 2022 02; 18(2):e1010333. Rixon JA, Depew CE, McSorley SJ. PMID: 35196366; PMCID: PMC8901068.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    9. CD4+ T cell immunity to Salmonella is transient in the circulation. PLoS Pathog. 2021 10; 17(10):e1010004. Peres NG, Wang N, Whitney P, Engel S, Shreenivas MM, Comerford I, Hocking DM, Erazo AB, Förster I, Kupz A, Gebhardt T, McColl SR, McSorley SJ, Bedoui S, Strugnell RA. PMID: 34695149; PMCID: PMC8568161.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Circulating immunity protects the female reproductive tract from Chlamydia infection. Proc Natl Acad Sci U S A. 2021 05 25; 118(21). Labuda JC, Pham OH, Depew CE, Fong KD, Lee BS, Rixon JA, McSorley SJ. PMID: 34001624; PMCID: PMC8166081.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    11. SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques. Nat Commun. 2021 01 22; 12(1):541. Shaan Lakshmanappa Y, Elizaldi SR, Roh JW, Schmidt BA, Carroll TD, Weaver KD, Smith JC, Verma A, Deere JD, Dutra J, Stone M, Franz S, Sammak RL, Olstad KJ, Rachel Reader J, Ma ZM, Nguyen NK, Watanabe J, Usachenko J, Immareddy R, Yee JL, Weiskopf D, Sette A, Hartigan-O'Connor D, McSorley SJ, Morrison JH, Tran NK, Simmons G, Busch MP, Kozlowski PA, Van Rompay KKA, Miller CJ, Iyer SS. PMID: 33483492; PMCID: PMC7822826.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    12. Maintenance of Type IV Secretion Function During Helicobacter pylori Infection in Mice. mBio. 2020 12 22; 11(6). Skoog EC, Martin ME, Barrozo RM, Hansen LM, Cai LP, Lee SJ, Benoun JM, McSorley SJ, Solnick JV. PMID: 33443133; PMCID: PMC8534286.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    13. Development of a Remote Monitoring Application to Improve Care and Support Patients in the First 30 Days Following Colorectal Cancer Surgery. Semin Oncol Nurs. 2020 12; 36(6):151086. Miller M, Roxburgh CS, McCann L, Connaghan J, Van-Wyk H, McSorley S, Maguire R. PMID: 33218885.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. SARS-CoV-2 infection induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques. Res Sq. 2020 Aug 14. Elizaldi S, Lakshmanappa YS, Roh J, Schmidt B, Carroll T, Weaver K, Smith J, Deere J, Dutra J, Stone M, Franz S, Sammak R, Olstad K, Reader JR, Ma ZM, Nguyen N, Watanabe J, Usachenko J, Immareddy R, Yee J, Weiskopf D, Sette A, Hartigan-O'Connor D, McSorley S, Morrison J, Tran N, Simmons G, Busch M, Kozlowsk P, van Rompay K, Miller C, Iyer S. PMID: 32818217; PMCID: PMC7430596.
      View in: PubMed   Mentions:
    15. SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques. bioRxiv. 2020 Jul 08. Elizaldi SR, Lakshmanappa YS, Roh JW, Schmidt BA, Carroll TD, Weaver KD, Smith JC, Deere JD, Dutra J, Stone M, Sammak RL, Olstad KJ, Reader JR, Ma ZM, Nguyen NK, Watanabe J, Usachaenko J, Immareddy R, Yee JL, Weiskopf D, Sette A, Hartigan-O'Connor D, McSorley SJ, Morrison JH, Tran NK, Simmons G, Busch MP, Kozlowski PA, Van Rompay KKA, Miller CJ, Iyer SS. PMID: 32676606; PMCID: PMC7359530.
      View in: PubMed   Mentions: 2  
    16. Development of canine PD-1/PD-L1 specific monoclonal antibodies and amplification of canine T cell function. PLoS One. 2020; 15(7):e0235518. Choi JW, Withers SS, Chang H, Spanier JA, De La Trinidad VL, Panesar H, Fife BT, Sciammas R, Sparger EE, Moore PF, Kent MS, Rebhun RB, McSorley SJ. PMID: 32614928; PMCID: PMC7332054.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    17. NOD1/NOD2 and RIP2 Regulate Endoplasmic Reticulum Stress-Induced Inflammation during Chlamydia Infection. mBio. 2020 06 02; 11(3). Pham OH, Lee B, Labuda J, Keestra-Gounder AM, Byndloss MX, Tsolis RM, McSorley SJ. PMID: 32487756; PMCID: PMC7267884.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    18. Antibody, but not B-cell-dependent antigen presentation, plays an essential role in preventing Chlamydia systemic dissemination in mice. Eur J Immunol. 2020 05; 50(5):676-684. Malaviarachchi PA, Mercado MAB, McSorley SJ, Li LX. PMID: 32026472; PMCID: PMC7199221.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    19. Unexpected Role of CD8 T Cells in Accelerated Clearance of Salmonella enterica Serovar Typhimurium from H-2 Congenic mice. Infect Immun. 2019 11; 87(11). Labuda JC, Depew CE, Pham OH, Benoun JM, Ramirez NA, McSorley SJ. PMID: 31427450; PMCID: PMC6803338.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    20. Metastatic immune infiltrates correlate with those of the primary tumour in canine osteosarcoma. Vet Comp Oncol. 2019 Sep; 17(3):242-252. Withers SS, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Burton JH, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB. PMID: 30684301; PMCID: PMC6658355.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    21. Optimal protection against Salmonella infection requires noncirculating memory. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):10416-10421. Benoun JM, Peres NG, Wang N, Pham OH, Rudisill VL, Fogassy ZN, Whitney PG, Fernandez-Ruiz D, Gebhardt T, Pham QM, Puddington L, Bedoui S, Strugnell RA, McSorley SJ. PMID: 30254173; PMCID: PMC6187142.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCellsPHPublic Health
    22. Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma. Vet Comp Oncol. 2019 Mar; 17(1):49-60. Withers SS, Skorupski KA, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Rodriguez CO, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB. PMID: 30156029; PMCID: PMC6363827.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    23. Diversity in the T cell response to Chlamydia-sum are better than one. Immunol Lett. 2018 10; 202:59-64. Labuda JC, McSorley SJ. PMID: 30179654; PMCID: PMC6310219.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    24. Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs. Dev Comp Immunol. 2018 10; 87:64-74. Withers SS, Moore PF, Chang H, Choi JW, McSorley SJ, Kent MS, Monjazeb AM, Canter RJ, Murphy WJ, Sparger EE, Rebhun RB. PMID: 29859828; PMCID: PMC6197816.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    25. T cell expression of IL-18R and DR3 is essential for non-cognate stimulation of Th1 cells and optimal clearance of intracellular bacteria. PLoS Pathog. 2017 Aug; 13(8):e1006566. Pham OH, O'Donnell H, Al-Shamkhani A, Kerrinnes T, Tsolis RM, McSorley SJ. PMID: 28817719; PMCID: PMC5574617.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    26. CCR7 Deficiency Allows Accelerated Clearance of Chlamydia from the Female Reproductive Tract. J Immunol. 2017 10 01; 199(7):2547-2554. Li LX, Labuda JC, Imai DM, Griffey SM, McSorley SJ. PMID: 28801359; PMCID: PMC5605455.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    27. Dual Immunization with SseB/Flagellin Provides Enhanced Protection against Salmonella Infection Mediated by Circulating Memory Cells. J Immunol. 2017 08 15; 199(4):1353-1361. Lee SJ, Benoun J, Sheridan BS, Fogassy Z, Pham O, Pham QM, Puddington L, McSorley SJ. PMID: 28710253; PMCID: PMC5548602.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCellsPHPublic Health
    28. U-Omp19 from Brucella abortus Is a Useful Adjuvant for Vaccine Formulations against Salmonella Infection in Mice. Front Immunol. 2017; 8:171. Risso GS, Carabajal MV, Bruno LA, Ibañez AE, Coria LM, Pasquevich KA, Lee SJ, McSorley SJ, Briones G, Cassataro J. PMID: 28261222; PMCID: PMC5313482.
      View in: PubMed   Mentions: 12     Fields:    
    29. A Protective Vaccine against Chlamydia Genital Infection Using Vault Nanoparticles without an Added Adjuvant. Vaccines (Basel). 2017 Jan 19; 5(1). Jiang J, Liu G, Kickhoefer VA, Rome LH, Li LX, McSorley SJ, Kelly KA. PMID: 28106821; PMCID: PMC5371739.
      View in: PubMed   Mentions: 13  
    30. Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory. mBio. 2016 12 20; 7(6). Benoun JM, Labuda JC, McSorley SJ. PMID: 27999159; PMCID: PMC5181774.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    31. Salmonella Infection Enhances Erythropoietin Production by the Kidney and Liver, Which Correlates with Elevated Bacterial Burdens. Infect Immun. 2016 10; 84(10):2833-41. Li LX, Benoun JM, Weiskopf K, Garcia KC, McSorley SJ. PMID: 27456828; PMCID: PMC5038055.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    32. Adhesion Molecules Associated with Female Genital Tract Infection. PLoS One. 2016; 11(6):e0156605. Qualai J, Cantero J, Li LX, Carrascosa JM, Cabré E, Dern O, Sumoy L, Requena G, McSorley SJ, Genescà M. PMID: 27272720; PMCID: PMC4896633.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    33. Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential. PLoS One. 2016; 11(4):e0154253. Qualai J, Li LX, Cantero J, Tarrats A, Fernández MA, Sumoy L, Rodolosse A, McSorley SJ, Genescà M. PMID: 27119555; PMCID: PMC4847787.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    34. NOD1 and NOD2 signalling links ER stress with inflammation. Nature. 2016 Apr 21; 532(7599):394-7. Keestra-Gounder AM, Byndloss MX, Seyffert N, Young BM, Chávez-Arroyo A, Tsai AY, Cevallos SA, Winter MG, Pham OH, Tiffany CR, de Jong MF, Kerrinnes T, Ravindran R, Luciw PA, McSorley SJ, Bäumler AJ, Tsolis RM. PMID: 27007849; PMCID: PMC4869892.
      View in: PubMed   Mentions: 238     Fields:    Translation:HumansAnimalsCells
    35. Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi. Cell. 2016 Feb 25; 164(5):827-8. Song J, Wilhelm CL, Wangdi T, Maira-Litran T, Lee SJ, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Bäumler AJ, Pier GB, Galán JE, Yarovinsky F. PMID: 26919416; PMCID: PMC4963816.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    36. Contaminated water delivery as a simple and effective method of experimental Salmonella infection. Future Microbiol. 2015; 10(10):1615-27. O'Donnell H, Pham OH, Benoun JM, Ravesloot-Chávez MM, McSorley SJ. PMID: 26439708; PMCID: PMC4942118.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    37. Transient Loss of Protection Afforded by a Live Attenuated Non-typhoidal Salmonella Vaccine in Mice Co-infected with Malaria. PLoS Negl Trop Dis. 2015; 9(9):e0004027. Mooney JP, Lee SJ, Lokken KL, Nanton MR, Nuccio SP, McSorley SJ, Tsolis RM. PMID: 26366739; PMCID: PMC4569369.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    38. Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation. Immunity. 2015 Jul 21; 43(1):120-31. Di Niro R, Lee SJ, Vander Heiden JA, Elsner RA, Trivedi N, Bannock JM, Gupta NT, Kleinstein SH, Vigneault F, Gilbert TJ, Meffre E, McSorley SJ, Shlomchik MJ. PMID: 26187411; PMCID: PMC4523395.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    39. Divergent behavior of mucosal memory T cells. Mucosal Immunol. 2015 Jul; 8(4):731-4. Pham OH, McSorley SJ. PMID: 26059005; PMCID: PMC4930071.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    40. A re-evaluation of the role of B cells in protective immunity to Chlamydia infection. Immunol Lett. 2015 Apr; 164(2):88-93. Li LX, McSorley SJ. PMID: 25704502; PMCID: PMC4402208.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    41. Protective host immune responses to Salmonella infection. Future Microbiol. 2015; 10(1):101-10. Pham OH, McSorley SJ. PMID: 25598340; PMCID: PMC4323267.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    42. Salmonella as a model for non-cognate Th1 cell stimulation. Front Immunol. 2014; 5:621. O'Donnell H, McSorley SJ. PMID: 25540644; PMCID: PMC4261815.
      View in: PubMed   Mentions: 23     Fields:    
    43. Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9. Eur J Immunol. 2015 Feb; 45(2):513-24. Atif SM, Lee SJ, Li LX, Uematsu S, Akira S, Gorjestani S, Lin X, Schweighoffer E, Tybulewicz VL, McSorley SJ. PMID: 25430631; PMCID: PMC4324162.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    44. Direct visualization of endogenous Salmonella-specific B cells reveals a marked delay in clonal expansion and germinal center development. Eur J Immunol. 2015 Feb; 45(2):428-41. Nanton MR, Lee SJ, Atif SM, Nuccio SP, Taylor JJ, Bäumler AJ, Way SS, McSorley SJ. PMID: 25346524; PMCID: PMC4323875.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    45. Introduction to special issue on microbiome influences on host immunity. Immunol Lett. 2014 Dec; 162(2 Pt A):1-2. McSorley SJ, Khoruts A. PMID: 25124961.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    46. The Role of Non-Cognate T Cell Stimulation during Intracellular Bacterial Infection. Front Immunol. 2014; 5:319. McSorley SJ. PMID: 25071779; PMCID: PMC4089505.
      View in: PubMed   Mentions: 8     Fields:    
    47. Immunity to intestinal pathogens: lessons learned from Salmonella. Immunol Rev. 2014 Jul; 260(1):168-82. McSorley SJ. PMID: 24942689; PMCID: PMC4066191.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    48. Salmonella enterica serovar Typhi impairs CD4 T cell responses by reducing antigen availability. Infect Immun. 2014 Jun; 82(6):2247-54. Atif SM, Winter SE, Winter MG, McSorley SJ, Bäumler AJ. PMID: 24643532; PMCID: PMC4019166.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    49. Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells. Immunity. 2014 Feb 20; 40(2):213-24. O'Donnell H, Pham OH, Li LX, Atif SM, Lee SJ, Ravesloot MM, Stolfi JL, Nuccio SP, Broz P, Monack DM, Baumler AJ, McSorley SJ. PMID: 24508233; PMCID: PMC3960852.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    50. B cells enhance antigen-specific CD4 T cell priming and prevent bacteria dissemination following Chlamydia muridarum genital tract infection. PLoS Pathog. 2013 Oct; 9(10):e1003707. Li LX, McSorley SJ. PMID: 24204262; PMCID: PMC3814678.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    51. CD103-CD11b+ dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin. Mucosal Immunol. 2014 Jan; 7(1):68-77. Atif SM, Uematsu S, Akira S, McSorley SJ. PMID: 23632327; PMCID: PMC4032068.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    52. Paneth cells: targets of friendly fire. Nat Immunol. 2013 Feb; 14(2):114-6. McSorley SJ, Bevins CL. PMID: 23334825.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    53. Immune profiling with a Salmonella Typhi antigen microarray identifies new diagnostic biomarkers of human typhoid. Sci Rep. 2013; 3:1043. Liang L, Juarez S, Nga TV, Dunstan S, Nakajima-Sasaki R, Davies DH, McSorley S, Baker S, Felgner PL. PMID: 23304434; PMCID: PMC3540400.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    54. Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion. J Immunol. 2012 Dec 15; 189(12):5503-7. Nanton MR, Way SS, Shlomchik MJ, McSorley SJ. PMID: 23150714; PMCID: PMC3518619.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    55. MHC class-I-restricted CD8 T cells play a protective role during primary Salmonella infection. Immunol Lett. 2012 Dec 17; 148(2):138-43. Lee SJ, Dunmire S, McSorley SJ. PMID: 23089550; PMCID: PMC3540194.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    56. Microbial-induced Th17: superhero or supervillain? J Immunol. 2012 Oct 01; 189(7):3285-91. McGeachy MJ, McSorley SJ. PMID: 22997231; PMCID: PMC3652671.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    57. Increased susceptibility to Salmonella infection in signal regulatory protein α-deficient mice. J Immunol. 2012 Sep 01; 189(5):2537-44. Li LX, Atif SM, Schmiel SE, Lee SJ, McSorley SJ. PMID: 22851710; PMCID: PMC3424330.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    58. The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells. Nat Immunol. 2012 Jun 17; 13(8):729-36. Kanaya T, Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, Hemmi H, Knoop KA, Kumar N, Sato M, Katsuno T, Yokosuka O, Toyooka K, Nakai K, Sakamoto A, Kitahara Y, Jinnohara T, McSorley SJ, Kaisho T, Williams IR, Ohno H. PMID: 22706340; PMCID: PMC3704196.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    59. Meeting report: a symposium on the evolution of common molecular pathways underlying innate immunity. Microbes Infect. 2012 Aug; 14(9):667-71. Gardner MB, Baumgarth N, Fell A, McSorley SJ, Solnick JV, Bevins CL. PMID: 22580093.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    60. Identification of a common immune signature in murine and human systemic Salmonellosis. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4998-5003. Lee SJ, Liang L, Juarez S, Nanton MR, Gondwe EN, Msefula CL, Kayala MA, Necchi F, Heath JN, Hart P, Tsolis RM, Heyderman RS, MacLennan CA, Felgner PL, Davies DH, McSorley SJ. PMID: 22331879; PMCID: PMC3324033.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsPHPublic Health
    61. Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development. PLoS Pathog. 2012 Jan; 8(1):e1002499. Lee SJ, McLachlan JB, Kurtz JR, Fan D, Winter SE, Baumler AJ, Jenkins MK, McSorley SJ. PMID: 22275869; PMCID: PMC3262010.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    62. TLR5-deficient mice lack basal inflammatory and metabolic defects but exhibit impaired CD4 T cell responses to a flagellated pathogen. J Immunol. 2011 May 01; 186(9):5406-12. Letran SE, Lee SJ, Atif SM, Flores-Langarica A, Uematsu S, Akira S, Cunningham AF, McSorley SJ. PMID: 21451112; PMCID: PMC4090138.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    63. Generation of Salmonella-specific Th1 cells requires sustained antigen stimulation. Vaccine. 2011 Mar 24; 29(15):2697-704. Griffin AJ, McSorley SJ. PMID: 21315116; PMCID: PMC3051039.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCellsPHPublic Health
    64. Development of protective immunity to Salmonella, a mucosal pathogen with a systemic agenda. Mucosal Immunol. 2011 Jul; 4(4):371-82. Griffin AJ, McSorley SJ. PMID: 21307847; PMCID: PMC4084725.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    65. Dissemination of persistent intestinal bacteria via the mesenteric lymph nodes causes typhoid relapse. Infect Immun. 2011 Apr; 79(4):1479-88. Griffin AJ, Li LX, Voedisch S, Pabst O, McSorley SJ. PMID: 21263018; PMCID: PMC3067558.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    66. TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity. Eur J Immunol. 2011 Jan; 41(1):29-38. Letran SE, Lee SJ, Atif SM, Uematsu S, Akira S, McSorley SJ. PMID: 21182074; PMCID: PMC3652676.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    67. Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly. J Immunol. 2010 Nov 15; 185(10):6198-204. Jackson A, Nanton MR, O'Donnell H, Akue AD, McSorley SJ. PMID: 20952675; PMCID: PMC3137927.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    68. B7-H1 (programmed cell death ligand 1) is required for the development of multifunctional Th1 cells and immunity to primary, but not secondary, Salmonella infection. J Immunol. 2010 Aug 15; 185(4):2442-9. Lee SJ, O'Donnell H, McSorley SJ. PMID: 20639491; PMCID: PMC4017671.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    69. T cell and APC dynamics in situ control the outcome of vaccination. J Immunol. 2010 Jul 01; 185(1):239-52. Khanna KM, Blair DA, Vella AT, McSorley SJ, Datta SK, Lefrançois L. PMID: 20530268; PMCID: PMC2997353.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    70. Successful treatment of bacterial infection hinders development of acquired immunity. J Immunol. 2009 Jul 15; 183(2):1263-70. Griffin A, Baraho-Hassan D, McSorley SJ. PMID: 19542362; PMCID: PMC2706945.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    71. Culling of activated CD4 T cells during typhoid is driven by Salmonella virulence genes. J Immunol. 2009 Jun 15; 182(12):7838-45. Srinivasan A, Nanton M, Griffin A, McSorley SJ. PMID: 19494308; PMCID: PMC2731968.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    72. Tracking the dynamics of salmonella specific T cell responses. Curr Top Microbiol Immunol. 2009; 334:179-98. Moon JJ, McSorley SJ. PMID: 19521686; PMCID: PMC2732114.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    73. Expression of Toll/IL-1R domain-containing adaptor protein (TIRAP) is detrimental to primary clearance of Salmonella and is not required for the generation of protective immunity. Immunol Lett. 2008 Feb 15; 116(1):64-71. Jerke S, Srinivasan A, McSorley SJ. PMID: 18096248; PMCID: PMC2263078.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    74. Salmonella flagellin induces bystander activation of splenic dendritic cells and hinders bacterial replication in vivo. J Immunol. 2007 Nov 01; 179(9):6169-75. Salazar-Gonzalez RM, Srinivasan A, Griffin A, Muralimohan G, Ertelt JM, Ravindran R, Vella AT, McSorley SJ. PMID: 17947692.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    75. Feeding by the tick, Ixodes scapularis, causes CD4(+) T cells responding to cognate antigen to develop the capacity to express IL-4. Parasite Immunol. 2007 Oct; 29(10):485-99. Müller-Doblies UU, Maxwell SS, Boppana VD, Mihalyo MA, McSorley SJ, Vella AT, Adler AJ, Wikel SK. PMID: 17883452.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    76. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity. 2007 Aug; 27(2):203-13. Moon JJ, Chu HH, Pepper M, McSorley SJ, Jameson SC, Kedl RM, Jenkins MK. PMID: 17707129; PMCID: PMC2200089.
      View in: PubMed   Mentions: 555     Fields:    Translation:AnimalsCellsPHPublic Health
    77. CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12075-80. Ravindran R, Rusch L, Itano A, Jenkins MK, McSorley SJ. PMID: 17615242; PMCID: PMC1907313.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    78. Innate immune activation of CD4 T cells in salmonella-infected mice is dependent on IL-18. J Immunol. 2007 May 15; 178(10):6342-9. Srinivasan A, Salazar-Gonzalez RM, Jarcho M, Sandau MM, Lefrancois L, McSorley SJ. PMID: 17475863.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    79. Interview with Dr. Stephen J. McSorley and Ms. Aparna Srinivasan regarding Pivotal Advance: secondary exposure to LPS suppresses CD4+ T cells and exacerbates murine typhoid. Interview by Helene F. Rosenberg. J Leukoc Biol. 2007 Feb; 81(2):401-2. McSorley SJ, Srinivasan A. PMID: 17142616.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    80. Pivotal advance: exposure to LPS suppresses CD4+ T cell cytokine production in Salmonella-infected mice and exacerbates murine typhoid. J Leukoc Biol. 2007 Feb; 81(2):403-11. Srinivasan A, McSorley SJ. PMID: 16916961.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    81. CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches. Immunity. 2006 May; 24(5):623-32. Salazar-Gonzalez RM, Niess JH, Zammit DJ, Ravindran R, Srinivasan A, Maxwell JR, Stoklasek T, Yadav R, Williams IR, Gu X, McCormick BA, Pazos MA, Vella AT, Lefrancois L, Reinecker HC, McSorley SJ. PMID: 16713979; PMCID: PMC2855652.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    82. Activation of Salmonella-specific immune responses in the intestinal mucosa. Arch Immunol Ther Exp (Warsz). 2006 Jan-Feb; 54(1):25-31. Srinivasan A, McSorley SJ. PMID: 16642254.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    83. Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection. J Immunol. 2005 Oct 01; 175(7):4603-10. Ravindran R, Foley J, Stoklasek T, Glimcher LH, McSorley SJ. PMID: 16177105.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    84. Salmonella flagellin, a microbial target of the innate and adaptive immune system. Immunol Lett. 2005 Nov 15; 101(2):117-22. Salazar-Gonzalez RM, McSorley SJ. PMID: 15975666.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    85. Tracking the dynamics of T-cell activation in response to Salmonella infection. Immunology. 2005 Apr; 114(4):450-8. Ravindran R, McSorley SJ. PMID: 15804280; PMCID: PMC1782102.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    86. It's not just theologians who are morally troubled. Nature. 2005 Jan 27; 433(7024):355. McSorley SJ. PMID: 15674263.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    87. Low-dose Salmonella infection evades activation of flagellin-specific CD4 T cells. J Immunol. 2004 Sep 15; 173(6):4091-9. Srinivasan A, Foley J, Ravindran R, McSorley SJ. PMID: 15356159.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    88. Visualizing the immune response to pathogens. Curr Opin Immunol. 2004 Aug; 16(4):494-8. Srinivasan A, McSorley SJ. PMID: 15245745.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    89. Massive number of antigen-specific CD4 T cells during vaccination with live attenuated Salmonella causes interclonal competition. J Immunol. 2004 Jun 01; 172(11):6884-93. Srinivasan A, Foley J, McSorley SJ. PMID: 15153507.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCellsPHPublic Health
    90. T cell clonal conditioning: a phase occurring early after antigen presentation but before clonal expansion is impacted by Toll-like receptor stimulation. J Immunol. 2004 Jan 01; 172(1):248-59. Maxwell JR, Rossi RJ, McSorley SJ, Vella AT. PMID: 14688332.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    91. Bioethics: role of religion cannot be ignored. Nature. 2003 Oct 23; 425(6960):763. McSorley SJ. PMID: 14574380.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    92. Bioethics needs a distinct voice if it is to aid science. Nature. 2003 Oct 23; 425(6960):763. Lawen A. PMID: 14574381.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    93. Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity. 2003 Jul; 19(1):47-57. Itano AA, McSorley SJ, Reinhardt RL, Ehst BD, Ingulli E, Rudensky AY, Jenkins MK. PMID: 12871638.
      View in: PubMed   Mentions: 293     Fields:    Translation:AnimalsCells
    94. Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo. J Immunol. 2002 Oct 01; 169(7):3914-9. McSorley SJ, Ehst BD, Yu Y, Gewirtz AT. PMID: 12244190.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    95. Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection. Immunity. 2002 Mar; 16(3):365-77. McSorley SJ, Asch S, Costalonga M, Reinhardt RL, Jenkins MK. PMID: 11911822.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    96. In vivo activation of antigen-specific CD4 T cells. Annu Rev Immunol. 2001; 19:23-45. Jenkins MK, Khoruts A, Ingulli E, Mueller DL, McSorley SJ, Reinhardt RL, Itano A, Pape KA. PMID: 11244029.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    97. Priming by microbial antigens from the intestinal flora determines the ability of CD4+ T cells to rapidly secrete IL-4 in BALB/c mice infected with Leishmania major. J Immunol. 2000 Nov 15; 165(10):5637-45. Julia V, McSorley SS, Malherbe L, Breittmayer JP, Girard-Pipau F, Beck A, Glaichenhaus N. PMID: 11067920.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    98. Antibody is required for protection against virulent but not attenuated Salmonella enterica serovar typhimurium. Infect Immun. 2000 Jun; 68(6):3344-8. McSorley SJ, Jenkins MK. PMID: 10816483; PMCID: PMC97596.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    99. Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium. J Immunol. 2000 Jan 15; 164(2):986-93. McSorley SJ, Cookson BT, Jenkins MK. PMID: 10623848.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    100. Vaccination by inducing oral tolerance? Immunol Today. 1999 Dec; 20(12):555-60. McSorley SJ, Garside P. PMID: 10562706.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsPHPublic Health
    101. Selective tolerization of Th1-like cells after nasal administration of a cholera toxoid-LACK conjugate. Eur J Immunol. 1998 Feb; 28(2):424-32. McSorley SJ, Rask C, Pichot R, Julia V, Czerkinsky C, Glaichenhaus N. PMID: 9521049.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    102. Protective effect on Leishmania major infection of migration inhibitory factor, TNF-alpha, and IFN-gamma administered orally via attenuated Salmonella typhimurium. J Immunol. 1998 Feb 01; 160(3):1285-9. Xu D, McSorley SJ, Tetley L, Chatfield S, Dougan G, Chan WL, Satoskar A, David JR, Liew FY. PMID: 9570545.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    103. Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells. Immunity. 1997 Sep; 7(3):401-9. McSorley SJ, Soldera S, Malherbe L, Carnaud C, Locksley RM, Flavell RA, Glaichenhaus N. PMID: 9324360.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    104. Selective down-regulation of Th2 immune responses following treatment with antigen-coupled splenocytes. Eur J Immunol. 1997 Apr; 27(4):848-54. Soldera S, McSorley SJ, Glaichenhaus N. PMID: 9130634.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    105. Vaccine efficacy of Salmonella strains expressing glycoprotein 63 with different promoters. Infect Immun. 1997 Jan; 65(1):171-8. McSorley SJ, Xu D, Liew FY. PMID: 8975908; PMCID: PMC174572.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    106. Immunology of murine leishmaniasis. Clin Dermatol. 1996 Sep-Oct; 14(5):451-64. McSorley S, Proudfoot L, O'Donnell CA, Liew FY. PMID: 8889322.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    107. Protection against Leishmania major infection in genetically susceptible BALB/c mice by gp63 delivered orally in attenuated Salmonella typhimurium (AroA- AroD-). Immunology. 1995 May; 85(1):1-7. Xu D, McSorley SJ, Chatfield SN, Dougan G, Liew FY. PMID: 7635511; PMCID: PMC1384017.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCellsPHPublic Health
    108. Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. Eur J Immunol. 1994 Apr; 24(4):980-4. Taylor-Robinson AW, Liew FY, Severn A, Xu D, McSorley SJ, Garside P, Padron J, Phillips RS. PMID: 8149966.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
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