Koen K Van Rompay

Title(s)Professional Researcher, Primate Center
SchoolResearch
AddressLBS0023844
CA 95616
Phone530-752-5281
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    Other Positions
    Title(s)Senior Lecturer, VM: Pathology, Microbiology, & Immunology

    Title(s)Professional Researcher, VM: Pathology, Microbiology, & Immunology


    Collapse Research 
    Collapse research activities and funding
    Development of a nonhuman primate model of fetal Zika virus infection and disease
    NIH R21AI129479Nov 14, 2016 - Oct 31, 2019
    Role: Principal Investigator
    Topical virucides to prevent oral transmission
    NIH R21AI058056Jul 1, 2003 - Jun 30, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques. Nat Commun. 2021 01 22; 12(1):541. Shaan Lakshmanappa Y, Elizaldi SR, Roh JW, Schmidt BA, Carroll TD, Weaver KD, Smith JC, Verma A, Deere JD, Dutra J, Stone M, Franz S, Sammak RL, Olstad KJ, Rachel Reader J, Ma ZM, Nguyen NK, Watanabe J, Usachenko J, Immareddy R, Yee JL, Weiskopf D, Sette A, Hartigan-O'Connor D, McSorley SJ, Morrison JH, Tran NK, Simmons G, Busch MP, Kozlowski PA, Van Rompay KKA, Miller CJ, Iyer SS. PMID: 33483492; PMCID: PMC7822826.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    2. A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7981-7989. Van Rompay KKA, Coffey LL, Kapoor T, Gazumyan A, Keesler RI, Jurado A, Peace A, Agudelo M, Watanabe J, Usachenko J, Singapuri A, Immareddy R, Ardeshir A, Stuart JB, Bournazos S, Ravetch JV, Balderes PJ, Lorenz IC, Esswein SR, Keeffe JR, Bjorkman PJ, Wang Q, Rice CM, MacDonald MR, Nussenzweig MC, Robbiani DF. PMID: 32209664; PMCID: PMC7149495.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    3. DNA vaccination before conception protects Zika virus-exposed pregnant macaques against prolonged viremia and improves fetal outcomes. Sci Transl Med. 2019 12 18; 11(523). Van Rompay KKA, Keesler RI, Ardeshir A, Watanabe J, Usachenko J, Singapuri A, Cruzen C, Bliss-Moreau E, Murphy AM, Yee JL, Webster H, Dennis M, Singh T, Heimsath H, Lemos D, Stuart J, Morabito KM, Foreman BM, Burgomaster KE, Noe AT, Dowd KA, Ball E, Woolard K, Presicce P, Kallapur SG, Permar SR, Foulds KE, Coffey LL, Pierson TC, Graham BS. PMID: 31852797; PMCID: PMC7093037.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCellsPHPublic Health
    4. Dolutegravir Monotherapy of Simian Immunodeficiency Virus-Infected Macaques Selects for Several Patterns of Resistance Mutations with Variable Virological Outcomes. J Virol. 2019 01 15; 93(2). Van Rompay KKA, Hassounah S, Keele BF, Lifson JD, Ardeshir A, Watanabe J, Pham HT, Chertova E, Sowder R, Balzarini J, Mesplède T, Wainberg MA. PMID: 30381490; PMCID: PMC6321921.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    5. Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. Nat Med. 2018 08; 24(8):1104-1107. Dudley DM, Van Rompay KK, Coffey LL, Ardeshir A, Keesler RI, Bliss-Moreau E, Grigsby PL, Steinbach RJ, Hirsch AJ, MacAllister RP, Pecoraro HL, Colgin LM, Hodge T, Streblow DN, Tardif S, Patterson JL, Tamhankar M, Seferovic M, Aagaard KM, Martín CS, Chiu CY, Panganiban AT, Veazey RS, Wang X, Maness NJ, Gilbert MH, Bohm RP, Adams Waldorf KM, Gale M, Rajagopal L, Hotchkiss CE, Mohr EL, Capuano SV, Simmons HA, Mejia A, Friedrich TC, Golos TG, O'Connor DH. PMID: 29967348; PMCID: PMC6082723.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    6. Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease. Nat Commun. 2018 06 20; 9(1):2414. Coffey LL, Keesler RI, Pesavento PA, Woolard K, Singapuri A, Watanabe J, Cruzen C, Christe KL, Usachenko J, Yee J, Heng VA, Bliss-Moreau E, Reader JR, von Morgenland W, Gibbons AM, Jackson K, Ardeshir A, Heimsath H, Permar S, Senthamaraikannan P, Presicce P, Kallapur SG, Linnen JM, Gao K, Orr R, MacGill T, McClure M, McFarland R, Morrison JH, Van Rompay KKA. PMID: 29925843; PMCID: PMC6010452.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    7. Hippocampal Neuronal Loss in Infant Macaques Orally Infected with Virulent Simian Immunodeficiency Virus (SIV). Brain Sci. 2017 Apr 10; 7(4). Carryl H, Van Rompay KK, De Paris K, Burke MW. PMID: 28394273; PMCID: PMC5406697.
      View in: PubMed   Mentions: 7  
    8. Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal. Retrovirology. 2012 Jul 17; 9:57. Van Rompay KK, Trott KA, Jayashankar K, Geng Y, LaBranche CC, Johnson JA, Landucci G, Lipscomb J, Tarara RP, Canfield DR, Heneine W, Forthal DN, Montefiori D, Abel K. PMID: 22805180; PMCID: PMC3419085.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    9. Compared to subcutaneous tenofovir, oral tenofovir disoproxyl fumarate administration preferentially concentrates the drug into gut-associated lymphoid cells in simian immunodeficiency virus-infected macaques. Antimicrob Agents Chemother. 2012 Sep; 56(9):4980-4. Van Rompay KK, Babusis D, Abbott Z, Geng Y, Jayashankar K, Johnson JA, Lipscomb J, Heneine W, Abel K, Ray AS. PMID: 22777046; PMCID: PMC3421865.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    10. Animal models of HIV transmission through breastfeeding and pediatric HIV infection. Adv Exp Med Biol. 2012; 743:89-108. Van Rompay KK, Jayashankar K. PMID: 22454344.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsPHPublic Health
    11. The use of nonhuman primate models of HIV infection for the evaluation of antiviral strategies. AIDS Res Hum Retroviruses. 2012 Jan; 28(1):16-35. Van Rompay KK. PMID: 21902451.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    12. Evaluation of antiretrovirals in animal models of HIV infection. Antiviral Res. 2010 Jan; 85(1):159-75. Van Rompay KK. PMID: 19622373.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    13. Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effects. Antimicrob Agents Chemother. 2008 Sep; 52(9):3144-60. Van Rompay KK, Durand-Gasselin L, Brignolo LL, Ray AS, Abel K, Cihlar T, Spinner A, Jerome C, Moore J, Kearney BP, Marthas ML, Reiser H, Bischofberger N. PMID: 18573931; PMCID: PMC2533487.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    14. Empowering the people: development of an HIV peer education model for low literacy rural communities in India. Hum Resour Health. 2008 Apr 18; 6:6. Van Rompay KK, Madhivanan P, Rafiq M, Krupp K, Chakrapani V, Selvam D. PMID: 18423006; PMCID: PMC2377249.
      View in: PubMed   Mentions: 27     Fields:    
    15. Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. Retrovirology. 2007 Apr 06; 4:25. Van Rompay KK, Johnson JA, Blackwood EJ, Singh RP, Lipscomb J, Matthews TB, Marthas ML, Pedersen NC, Bischofberger N, Heneine W, North TW. PMID: 17417971; PMCID: PMC1852805.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    16. Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus. J Acquir Immune Defic Syndr. 2006 Sep; 43(1):6-14. Van Rompay KK, Kearney BP, Sexton JJ, Colón R, Lawson JR, Blackwood EJ, Lee WA, Bischofberger N, Marthas ML. PMID: 16810108.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    17. Structured treatment interruptions with tenofovir monotherapy for simian immunodeficiency virus-infected newborn macaques. J Virol. 2006 Jul; 80(13):6399-410. Van Rompay KK, Singh RP, Heneine W, Johnson JA, Montefiori DC, Bischofberger N, Marthas ML. PMID: 16775328; PMCID: PMC1488952.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    18. Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11. Virol J. 2006 Apr 03; 3:22. Van Rompay KK, Blackwood EJ, Landucci G, Forthal D, Marthas ML. PMID: 16584561; PMCID: PMC1500998.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    19. Pharmacokinetics of tenofovir in breast milk of lactating rhesus macaques. Antimicrob Agents Chemother. 2005 May; 49(5):2093-4. Van Rompay KK, Hamilton M, Kearney B, Bischofberger N. PMID: 15855535; PMCID: PMC1087653.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    20. Antiretroviral drug studies in nonhuman primates: a valid animal model for innovative drug efficacy and pathogenesis experiments. AIDS Rev. 2005 Apr-Jun; 7(2):67-83. Van Rompay KK. PMID: 16092501.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    21. Motor-biking through rural India on an HIV mission. AIDS. 2004 Nov 05; 18(16):N13-6. Van Rompay KK. PMID: 15577642.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    22. Tenofovir primes rhesus macaque cells in vitro for enhanced interleukin-12 secretion. Antiviral Res. 2004 Aug; 63(2):133-8. Van Rompay KK, Marthas ML, Bischofberger N. PMID: 15302142.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. The clinical benefits of tenofovir for simian immunodeficiency virus-infected macaques are larger than predicted by its effects on standard viral and immunologic parameters. J Acquir Immune Defic Syndr. 2004 Aug 01; 36(4):900-14. Van Rompay KK, Singh RP, Brignolo LL, Lawson JR, Schmidt KA, Pahar B, Canfield DR, Tarara RP, Sodora DL, Bischofberger N, Marthas ML. PMID: 15220696.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    24. CD8+-cell-mediated suppression of virulent simian immunodeficiency virus during tenofovir treatment. J Virol. 2004 May; 78(10):5324-37. Van Rompay KK, Singh RP, Pahar B, Sodora DL, Wingfield C, Lawson JR, Marthas ML, Bischofberger N. PMID: 15113912; PMCID: PMC400346.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    25. Biological effects of short-term or prolonged administration of 9-[2-(phosphonomethoxy)propyl]adenine (tenofovir) to newborn and infant rhesus macaques. Antimicrob Agents Chemother. 2004 May; 48(5):1469-87. Van Rompay KK, Brignolo LL, Meyer DJ, Jerome C, Tarara R, Spinner A, Hamilton M, Hirst LL, Bennett DR, Canfield DR, Dearman TG, Von Morgenland W, Allen PC, Valverde C, Castillo AB, Martin RB, Samii VF, Bendele R, Desjardins J, Marthas ML, Pedersen NC, Bischofberger N. PMID: 15105094; PMCID: PMC400569.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
    26. Topical administration of low-dose tenofovir disoproxil fumarate to protect infant macaques against multiple oral exposures of low doses of simian immunodeficiency virus. J Infect Dis. 2002 Nov 15; 186(10):1508-13. Van Rompay KK, Schmidt KA, Lawson JR, Singh R, Bischofberger N, Marthas ML. PMID: 12404171.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    27. Two low doses of tenofovir protect newborn macaques against oral simian immunodeficiency virus infection. J Infect Dis. 2001 Aug 15; 184(4):429-38. Van Rompay KK, McChesney MB, Aguirre NL, Schmidt KA, Bischofberger N, Marthas ML. PMID: 11471100.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    28. Prophylactic and therapeutic benefits of short-term 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) administration to newborn macaques following oral inoculation with simian immunodeficiency virus with reduced susceptibility to PMPA. J Virol. 2000 Feb; 74(4):1767-74. Van Rompay KK, Miller MD, Marthas ML, Margot NA, Dailey PJ, Canfield DR, Tarara RP, Cherrington JM, Aguirre NL, Bischofberger N, Pedersen NC. PMID: 10644348; PMCID: PMC111653.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    29. 9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) therapy prolongs survival of infant macaques inoculated with simian immunodeficiency virus with reduced susceptibility to PMPA. Antimicrob Agents Chemother. 1999 Apr; 43(4):802-12. Van Rompay KK, Cherrington JM, Marthas ML, Lamy PD, Dailey PJ, Canfield DR, Tarara RP, Bischofberger N, Pedersen NC. PMID: 10103184; PMCID: PMC89210.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    30. Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques. AIDS Res Hum Retroviruses. 1998 Jun 10; 14(9):761-73. Van Rompay KK, Marthas ML, Lifson JD, Berardi CJ, Vasquez GM, Agatep E, Dehqanzada ZA, Cundy KC, Bischofberger N, Pedersen NC. PMID: 9643376.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    31. 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob Agents Chemother. 1996 Nov; 40(11):2586-91. Van Rompay KK, Cherrington JM, Marthas ML, Berardi CJ, Mulato AS, Spinner A, Tarara RP, Canfield DR, Telm S, Bischofberger N, Pedersen NC. PMID: 8913470; PMCID: PMC163581.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
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