Marta Marthas

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    Collapse Research 
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    Passive-Active Immunization Strategies Against Pediatric AIDS
    NIH/NIAID R01AI062518Mar 1, 2006 - Feb 28, 2010
    Role: Principal Investigator
    Passive-Active Vaccine Strategies Against Pediatric AIDS
    NIH/NIAID R21AI062518Sep 30, 2004 - Feb 28, 2006
    Role: Principal Investigator
    Vaccine to Prevent HIV Infection in Pregnancy &Newborns
    NIH/NIAID R21AI052000Sep 1, 2002 - Aug 31, 2005
    Role: Principal Investigator
    NIH/NIAID R01AI046320Sep 1, 1999 - Jun 30, 2005
    Role: Principal Investigator
    NIH/NIAID R01AI039109Sep 30, 1995 - Aug 31, 2001
    Role: Principal Investigator
    NIH/NCRR R13RR011039Aug 1, 1995 - Jul 31, 1996
    Role: Principal Investigator
    NIH/NIAID R01AI031383Sep 30, 1991 - Jul 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Marthas ML, Van Rompay KK, Abbott Z, Earl P, Buonocore-Buzzelli L, Moss B, Rose NF, Rose JK, Kozlowski PA, Abel K. Partial efficacy of a VSV-SIV/MVA-SIV vaccine regimen against oral SIV challenge in infant macaques. Vaccine. 2011 Apr 12; 29(17):3124-37. PMID: 21377510; PMCID: PMC3078946.
    2. von Gegerfelt A, Valentin A, Alicea C, Van Rompay KK, Marthas ML, Montefiori DC, Pavlakis GN, Felber BK. Emergence of simian immunodeficiency virus-specific cytotoxic CD4+ T cells and increased humoral responses correlate with control of rebounding viremia in CD8-depleted macaques infected with Rev-independent live-attenuated simian immunodeficiency virus. J Immunol. 2010 Sep 15; 185(6):3348-58. PMID: 20702730.
      View in: PubMed
    3. Van Rompay KK, Abel K, Earl P, Kozlowski PA, Easlick J, Moore J, Buonocore-Buzzelli L, Schmidt KA, Wilson RL, Simon I, Moss B, Rose N, Rose J, Marthas ML. Immunogenicity of viral vector, prime-boost SIV vaccine regimens in infant rhesus macaques: attenuated vesicular stomatitis virus (VSV) and modified vaccinia Ankara (MVA) recombinant SIV vaccines compared to live-attenuated SIV. Vaccine. 2010 Feb 10; 28(6):1481-92. PMID: 19995539; PMCID: PMC2822069.
    4. Morgan C, Marthas M, Miller C, Duerr A, Cheng-Mayer C, Desrosiers R, Flores J, Haigwood N, Hu SL, Johnson RP, Lifson J, Montefiori D, Moore J, Robert-Guroff M, Robinson H, Self S, Corey L. The use of nonhuman primate models in HIV vaccine development. PLoS Med. 2008 Aug 12; 5(8):e173. PMID: 18700814; PMCID: PMC2504486.
    5. Van Rompay KK, Durand-Gasselin L, Brignolo LL, Ray AS, Abel K, Cihlar T, Spinner A, Jerome C, Moore J, Kearney BP, Marthas ML, Reiser H, Bischofberger N. Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effects. Antimicrob Agents Chemother. 2008 Sep; 52(9):3144-60. PMID: 18573931; PMCID: PMC2533487.
    6. Marthas ML, Miller CJ. Developing a neonatal HIV vaccine: insights from macaque models of pediatric HIV/AIDS. Curr Opin HIV AIDS. 2007 Sep; 2(5):367-74. PMID: 19372914.
      View in: PubMed
    7. Van Rompay KK, Johnson JA, Blackwood EJ, Singh RP, Lipscomb J, Matthews TB, Marthas ML, Pedersen NC, Bischofberger N, Heneine W, North TW. Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. Retrovirology. 2007 Apr 06; 4:25. PMID: 17417971; PMCID: PMC1852805.
    8. Florese RH, Van Rompay KK, Aldrich K, Forthal DN, Landucci G, Mahalanabis M, Haigwood N, Venzon D, Kalyanaraman VS, Marthas ML, Robert-Guroff M. Evaluation of passively transferred, nonneutralizing antibody-dependent cellular cytotoxicity-mediating IgG in protection of neonatal rhesus macaques against oral SIVmac251 challenge. J Immunol. 2006 Sep 15; 177(6):4028-36. PMID: 16951366.
      View in: PubMed
    9. Forthal DN, Landucci G, Cole KS, Marthas M, Becerra JC, Van Rompay K. Rhesus macaque polyclonal and monoclonal antibodies inhibit simian immunodeficiency virus in the presence of human or autologous rhesus effector cells. J Virol. 2006 Sep; 80(18):9217-25. PMID: 16940533; PMCID: PMC1563916.
    10. Van Rompay KK, Kearney BP, Sexton JJ, Colón R, Lawson JR, Blackwood EJ, Lee WA, Bischofberger N, Marthas ML. Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus. J Acquir Immune Defic Syndr. 2006 Sep; 43(1):6-14. PMID: 16810108.
      View in: PubMed
    11. Van Rompay KK, Singh RP, Heneine W, Johnson JA, Montefiori DC, Bischofberger N, Marthas ML. Structured treatment interruptions with tenofovir monotherapy for simian immunodeficiency virus-infected newborn macaques. J Virol. 2006 Jul; 80(13):6399-410. PMID: 16775328; PMCID: PMC1488952.
    12. Abel K, Pahar B, Van Rompay KK, Fritts L, Sin C, Schmidt K, Colón R, McChesney M, Marthas ML. Rapid virus dissemination in infant macaques after oral simian immunodeficiency virus exposure in the presence of local innate immune responses. J Virol. 2006 Jul; 80(13):6357-67. PMID: 16775324; PMCID: PMC1488945.
    13. von Gegerfelt AS, Alicea C, Valentin A, Morrow M, van Rompay KK, Ayash-Rashkovsky M, Markham P, Else JG, Marthas ML, Pavlakis GN, Ruprecht RM, Felber BK. Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques. AIDS Res Hum Retroviruses. 2006 Jun; 22(6):516-28. PMID: 16796527.
      View in: PubMed
    14. Van Rompay KK, Blackwood EJ, Landucci G, Forthal D, Marthas ML. Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11. Virol J. 2006 Apr 03; 3:22. PMID: 16584561; PMCID: PMC1500998.
    15. Greenier JL, Van Rompay KK, Montefiori D, Earl P, Moss B, Marthas ML. Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals. Virol J. 2005 Feb 14; 2:11. PMID: 15710048; PMCID: PMC552328.
    16. Van Rompay KK, Abel K, Lawson JR, Singh RP, Schmidt KA, Evans T, Earl P, Harvey D, Franchini G, Tartaglia J, Montefiori D, Hattangadi S, Moss B, Marthas ML. Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV. J Acquir Immune Defic Syndr. 2005 Feb 01; 38(2):124-34. PMID: 15671796.
      View in: PubMed
    17. Milush JM, Kosub D, Marthas M, Schmidt K, Scott F, Wozniakowski A, Brown C, Westmoreland S, Sodora DL. Rapid dissemination of SIV following oral inoculation. AIDS. 2004 Dec 03; 18(18):2371-80. PMID: 15622313.
      View in: PubMed
    18. Van Rompay KK, Marthas ML, Bischofberger N. Tenofovir primes rhesus macaque cells in vitro for enhanced interleukin-12 secretion. Antiviral Res. 2004 Aug; 63(2):133-8. PMID: 15302142.
      View in: PubMed
    19. Van Rompay KK, Singh RP, Brignolo LL, Lawson JR, Schmidt KA, Pahar B, Canfield DR, Tarara RP, Sodora DL, Bischofberger N, Marthas ML. The clinical benefits of tenofovir for simian immunodeficiency virus-infected macaques are larger than predicted by its effects on standard viral and immunologic parameters. J Acquir Immune Defic Syndr. 2004 Aug 01; 36(4):900-14. PMID: 15220696.
      View in: PubMed
    20. Belshe R, Franchini G, Girard MP, Gotch F, Kaleebu P, Marthas ML, McChesney MB, McCullough R, Mhalu F, Salmon-Ceron D, Sekaly RP, van Rompay K, Verrier B, Wahren B, Weissenbacher M. Support for the RV144 HIV vaccine trial. Science. 2004 Jul 09; 305(5681):177-80; author reply 177-80. PMID: 15247455.
      View in: PubMed
    21. Van Rompay KK, Brignolo LL, Meyer DJ, Jerome C, Tarara R, Spinner A, Hamilton M, Hirst LL, Bennett DR, Canfield DR, Dearman TG, Von Morgenland W, Allen PC, Valverde C, Castillo AB, Martin RB, Samii VF, Bendele R, Desjardins J, Marthas ML, Pedersen NC, Bischofberger N. Biological effects of short-term or prolonged administration of 9-[2-(phosphonomethoxy)propyl]adenine (tenofovir) to newborn and infant rhesus macaques. Antimicrob Agents Chemother. 2004 May; 48(5):1469-87. PMID: 15105094; PMCID: PMC400569.
    22. Van Rompay KK, Singh RP, Pahar B, Sodora DL, Wingfield C, Lawson JR, Marthas ML, Bischofberger N. CD8+-cell-mediated suppression of virulent simian immunodeficiency virus during tenofovir treatment. J Virol. 2004 May; 78(10):5324-37. PMID: 15113912; PMCID: PMC400346.
    23. Safrit JT, Ruprecht R, Ferrantelli F, Xu W, Kitabwalla M, Van Rompay K, Marthas M, Haigwood N, Mascola JR, Luzuriaga K, Jones SA, Mathieson BJ, Newell ML. Immunoprophylaxis to prevent mother-to-child transmission of HIV-1. J Acquir Immune Defic Syndr. 2004 Feb 01; 35(2):169-77. PMID: 14722451.
      View in: PubMed
    24. Vogel TU, Reynolds MR, Fuller DH, Vielhuber K, Shipley T, Fuller JT, Kunstman KJ, Sutter G, Marthas ML, Erfle V, Wolinsky SM, Wang C, Allison DB, Rud EW, Wilson N, Montefiori D, Altman JD, Watkins DI. Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239. J Virol. 2003 Dec; 77(24):13348-60. PMID: 14645590; PMCID: PMC296068.
    25. Van Rompay KK, Greenier JL, Cole KS, Earl P, Moss B, Steckbeck JD, Pahar B, Rourke T, Montelaro RC, Canfield DR, Tarara RP, Miller C, McChesney MB, Marthas ML. Immunization of newborn rhesus macaques with simian immunodeficiency virus (SIV) vaccines prolongs survival after oral challenge with virulent SIVmac251. J Virol. 2003 Jan; 77(1):179-90. PMID: 12477823; PMCID: PMC140621.
    26. Makori N, Tarantal AF, Lü FX, Rourke T, Marthas ML, McChesney MB, Hendrickx AG, Miller CJ. Functional and morphological development of lymphoid tissues and immune regulatory and effector function in rhesus monkeys: cytokine-secreting cells, immunoglobulin-secreting cells, and CD5(+) B-1 cells appear early in fetal development. Clin Diagn Lab Immunol. 2003 Jan; 10(1):140-53. PMID: 12522052; PMCID: PMC145291.
    27. Van Rompay KK, Schmidt KA, Lawson JR, Singh R, Bischofberger N, Marthas ML. Topical administration of low-dose tenofovir disoproxil fumarate to protect infant macaques against multiple oral exposures of low doses of simian immunodeficiency virus. J Infect Dis. 2002 Nov 15; 186(10):1508-13. PMID: 12404171.
      View in: PubMed
    28. Sodora DL, Milush JM, Ware F, Wozniakowski A, Montgomery L, McClure HM, Lackner AA, Marthas M, Hirsch V, Johnson RP, Douek DC, Koup RA. Decreased levels of recent thymic emigrants in peripheral blood of simian immunodeficiency virus-infected macaques correlate with alterations within the thymus. J Virol. 2002 Oct; 76(19):9981-90. PMID: 12208974; PMCID: PMC136511.
    29. Abel K, Alegria-Hartman MJ, Rothaeusler K, Marthas M, Miller CJ. The relationship between simian immunodeficiency virus RNA levels and the mRNA levels of alpha/beta interferons (IFN-alpha/beta) and IFN-alpha/beta-inducible Mx in lymphoid tissues of rhesus macaques during acute and chronic infection. J Virol. 2002 Aug; 76(16):8433-45. PMID: 12134046; PMCID: PMC155165.
    30. von Gegerfelt AS, Liska V, Li PL, McClure HM, Horie K, Nappi F, Montefiori DC, Pavlakis GN, Marthas ML, Ruprecht RM, Felber BK. Rev-independent simian immunodeficiency virus strains are nonpathogenic in neonatal macaques. J Virol. 2002 Jan; 76(1):96-104. PMID: 11739675; PMCID: PMC135725.
    31. Marthas ML, Lu D, Penedo MC, Hendrickx AG, Miller CJ. Titration of an SIVmac251 stock by vaginal inoculation of Indian and Chinese origin rhesus macaques: transmission efficiency, viral loads, and antibody responses. AIDS Res Hum Retroviruses. 2001 Oct 10; 17(15):1455-66. PMID: 11679158; PMCID: PMC3401017.