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First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody. Sci Adv. 2023 10 13; 9(41):eadh7968.
Omidvari N, Jones T, Price PM, Ferre AL, Lu J, Abdelhafez YG, Sen F, Cohen SH, Schmiedehausen K, Badawi RD, Shacklett BL, Wilson I, Cherry SR. PMID: 37824612; PMCID: PMC10569706.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
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The Emerging Role of MAIT Cell Responses in Viral Infections. J Immunol. 2023 08 15; 211(4):511-517.
Sandberg JK, Leeansyah E, Eller MA, Shacklett BL, Paquin-Proulx D. PMID: 37549397; PMCID: PMC10421619.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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The Association Between Heterosexual anal Intercourse and HIV Acquisition in Three Prospective Cohorts of Women. AIDS Behav. 2023 Dec; 27(12):4010-4021.
Silhol R, Nordsletten A, Maheu-Giroux M, Elmes J, Staunton R, Owen B, Shacklett B, McGowan I, Feliciano KG, van der Straten A, Eller LA, Robb M, Marrazzo J, Dimitrov D, Boily MC. PMID: 37392271; PMCID: PMC10598156.
View in:
PubMed Mentions: Fields:
Translation:
Humans
-
First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody. medRxiv. 2023 Mar 20.
Omidvari N, Jones T, Price PM, Ferre AL, Lu J, Abdelhafez YG, Sen F, Cohen SH, Schmiedehausen K, Badawi RD, Shacklett BL, Wilson I, Cherry SR. PMID: 36993568; PMCID: PMC10055575.
View in:
PubMed Mentions:
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Editorial: CD8+ T-cells in HIV/SIV infection, prophylaxis, and therapy. Front Immunol. 2023; 14:1159452.
Shacklett BL, Buggert M, Dias J. PMID: 36895565; PMCID: PMC9989259.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates With Immune Response. J Infect Dis. 2021 11 16; 224(9):1593-1598.
Wu G, Zuck P, Goh SL, Milush JM, Vohra P, Wong JK, Somsouk M, Yukl SA, Shacklett BL, Chomont N, Haase AT, Hatano H, Schacker TW, Deeks SG, Hazuda DJ, Hunt PW, Howell BJ. PMID: 33693750; PMCID: PMC8599810.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Deciphering the Role of Mucosal Immune Responses and the Cervicovaginal Microbiome in Resistance to HIV Infection in HIV-Exposed Seronegative (HESN) Women. Microbiol Spectr. 2021 10 31; 9(2):e0047021.
Munusamy Ponnan S, Thiruvengadam K, Tellapragada C, Ambikan AT, Narayanan A, Kathirvel S, Mathayan M, Shankar J, Rajaraman A, Afshan Amanulla M, Dinesha TR, Poongulali S, Saravanan S, Murugavel KG, Swaminathan S, Velu V, Shacklett B, Neogi U, Hanna LE. PMID: 34704803; PMCID: PMC8549735.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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The TLR7 agonist vesatolimod induced a modest delay in viral rebound in HIV controllers after cessation of antiretroviral therapy. Sci Transl Med. 2021 06 23; 13(599).
SenGupta D, Brinson C, DeJesus E, Mills A, Shalit P, Guo S, Cai Y, Wallin JJ, Zhang L, Humeniuk R, Begley R, Geleziunas R, Mellors J, Wrin T, Jones N, Milush J, Ferre AL, Shacklett BL, Laird GM, Moldt B, Vendrame E, Brainard DM, Ramgopal M, Deeks SG. PMID: 34162752.
-
Compartmentalization of cerebrospinal fluid inflammation across the spectrum of untreated HIV-1 infection, central nervous system injury and viral suppression. PLoS One. 2021; 16(5):e0250987.
Gisslen M, Keating SM, Spudich S, Arechiga V, Stephenson S, Zetterberg H, Di Germanio C, Blennow K, Fuchs D, Hagberg L, Norris PJ, Peterson J, Shacklett BL, Yiannoutsos CT, Price RW. PMID: 33983973; PMCID: PMC8118251.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
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The Role of Tissue Resident Memory CD4 T Cells in Herpes Simplex Viral and HIV Infection. Viruses. 2021 02 25; 13(3).
O'Neil TR, Hu K, Truong NR, Arshad S, Shacklett BL, Cunningham AL, Nasr N. PMID: 33668777; PMCID: PMC7996247.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Reproductive tract immune cells from pregnant women or those using depot medroxyprogesterone acetate show no excess susceptibility to HIV-1: Results of an ex vivo fusion assay. Contraception. 2021 01; 103(1):44-47.
Seidman D, Cavrois M, Hilton JF, Roan NR, Averbach S, Takeda M, Chang E, Raman N, Greenblatt R, Shacklett BL, Smith-McCune K. PMID: 33007299; PMCID: PMC7736211.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
-
RhCMV serostatus and vaccine adjuvant impact immunogenicity of RhCMV/SIV vaccines. Sci Rep. 2020 08 20; 10(1):14056.
Chang WLW, Deere JD, Kieu HT, Castillo LD, Machmach K, Shen X, Tomaras GD, Shacklett BL, Barry PA, Hartigan-O'Connor DJ, Sparger EE. PMID: 32820216; PMCID: PMC7441386.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
-
Receptive anal sex contributes substantially to heterosexually acquired HIV infections among at-risk women in twenty US cities: Results from a modelling analysis. Am J Reprod Immunol. 2020 08; 84(2):e13263.
Elmes J, Silhol R, Hess KL, Gedge LM, Nordsletten A, Staunton R, Anton P, Shacklett B, McGowan I, Dang Q, Adimora AA, Dimitrov DT, Aral S, Handanagic S, Paz-Bailey G, Boily MC. PMID: 32384198; PMCID: PMC7485995.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
-
Parallel studies of mucosal immunity in the reproductive and gastrointestinal mucosa of HIV-infected women. Am J Reprod Immunol. 2020 07; 84(1):e13246.
Shanmugasundaram U, Critchfield JW, Giudice LC, Smith-McCune K, Greenblatt RM, Shacklett BL. PMID: 32301548; PMCID: PMC7302888.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Defining T Cell Tissue Residency in Humans: Implications for HIV Pathogenesis and Vaccine Design. Curr HIV/AIDS Rep. 2020 04; 17(2):109-117.
Shacklett BL, Ferre AL, Kiniry BE. PMID: 32052270; PMCID: PMC7072053.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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What Proportion of Female Sex Workers Practise anal Intercourse and How Frequently? A Systematic Review and Meta-analysis. AIDS Behav. 2020 Mar; 24(3):697-713.
Owen BN, Baggaley RF, Elmes J, Harvey A, Shubber Z, Butler AR, Silhol R, Anton P, Shacklett B, van der Straten A, Boily MC. PMID: 30953304; PMCID: PMC6778486.
View in:
PubMed Mentions:
11 Fields:
Translation:
Humans
-
Increases in HIV Incidence Following Receptive Anal Intercourse Among Women: A Systematic Review and Meta-analysis. AIDS Behav. 2020 Mar; 24(3):667-681.
Stannah J, Silhol R, Elmes J, Owen B, Shacklett BL, Anton P, McGowan I, van der Straten A, Dimitrov D, Baggaley RF, Boily MC. PMID: 31486008; PMCID: PMC7018785.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansPHPublic Health
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Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection. Nat Commun. 2020 01 14; 11(1):272.
Lal KG, Kim D, Costanzo MC, Creegan M, Leeansyah E, Dias J, Paquin-Proulx D, Eller LA, Schuetz A, Phuang-Ngern Y, Krebs SJ, Slike BM, Kibuuka H, Maganga L, Nitayaphan S, Kosgei J, Sacdalan C, Ananworanich J, Bolton DL, Michael NL, Shacklett BL, Robb ML, Eller MA, Sandberg JK. PMID: 31937782; PMCID: PMC6959336.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Effects of the levonorgestrel-containing intrauterine device, copper intrauterine device, and levonorgestrel-containing oral contraceptive on susceptibility of immune cells from cervix, endometrium and blood to HIV-1 fusion measured ex vivo. PLoS One. 2019; 14(8):e0221181.
Cavrois M, Hilton JF, Roan NR, Takeda M, Seidman D, Averbach S, Chang E, Raman N, Greenblatt R, Shacklett BL, Smith-McCune K. PMID: 31437197; PMCID: PMC6705759.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy. AIDS. 2019 07 01; 33(8):1293-1306.
Cattin A, Wiche Salinas TR, Gosselin A, Planas D, Shacklett B, Cohen EA, Ghali MP, Routy JP, Ancuta P. PMID: 30870200; PMCID: PMC6686847.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
-
HIV Research for Prevention 2018: From Research to Impact Conference Summary and Highlights. AIDS Res Hum Retroviruses. 2019 07; 35(7):598-607.
Shacklett BL, Blanco J, Hightow-Weidman L, Mgodi N, Alcamí J, Buchbinder S, Chirenje M, Dabee S, Diallo M, Dumchev K, Herrera C, Levy ME, Martin Gayo E, Makoah NA, Mitchell KM, Mugwanya K, Reddy K, Rodríguez ML, Rodriguez-Garcia M, Shover CL, Shrivastava T, Tomaras G, Van Diepen M, Walia M, Warren M, Manrique A, Thyagarajan B, Torri T. PMID: 31007035; PMCID: PMC6602109.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
-
Tissue issues: mucosal T-cell responses in HIV-1 infection. Curr Opin HIV AIDS. 2019 03; 14(2):100-107.
Shacklett BL, Ferre AL, Kiniry BE. PMID: 30601239; PMCID: PMC6355347.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Mucosal Immunity in HIV/SIV Infection: T Cells, B Cells and Beyond. Curr Immunol Rev. 2019; 15(1):63-75.
Shacklett BL. PMID: 31327960; PMCID: PMC6640863.
View in:
PubMed Mentions:
11
-
Does per-act HIV-1 transmission risk through anal sex vary by gender? An updated systematic review and meta-analysis. Am J Reprod Immunol. 2018 11; 80(5):e13039.
Baggaley RF, Owen BN, Silhol R, Elmes J, Anton P, McGowan I, van der Straten A, Shacklett B, Dang Q, Swann EM, Bolton DL, Boily MC. PMID: 30175479; PMCID: PMC6202169.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansCells
-
Cryopreservation of human mucosal tissues. PLoS One. 2018; 13(7):e0200653.
Hughes SM, Ferre AL, Yandura SE, Shetler C, Baker CAR, Calienes F, Levy CN, Astronomo RD, Shu Z, Lentz GM, Fialkow M, Kirby AC, McElrath MJ, Sinclair E, Rohan LC, Anderson PL, Shacklett BL, Dezzutti CS, Gao D, Hladik F. PMID: 30059507; PMCID: PMC6066204.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection. J Immunol. 2018 03 01; 200(5):1876-1888.
Kiniry BE, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL. PMID: 29352005; PMCID: PMC5821568.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Detection of HIV-1-specific gastrointestinal tissue resident CD8+ T-cells in chronic infection. Mucosal Immunol. 2018 05; 11(3):909-920.
Kiniry BE, Li S, Ganesh A, Hunt PW, Somsouk M, Skinner PJ, Deeks SG, Shacklett BL. PMID: 29139476; PMCID: PMC5953759.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansCells
-
HIVR4P 2016, Partnering for Prevention: Conference Summary and Highlights. AIDS Res Hum Retroviruses. 2017 08; 33(8):749-759.
Shacklett BL, Derdeyn CA, Folayan MO, Landovitz RJ, Anthony C, Behrens AJ, Hope TJ, Landais E, Leal L, Marrazzo JM, Morris L, Mugo N, Ngure K, Noseda V, Ranasinghe S, Tully DC, Voronin Y, Warren M, Wibmer CK, Xie IY, Scarlatti G, Thyagarajan B. PMID: 28649869; PMCID: PMC5564036.
View in:
PubMed Mentions: Fields:
Translation:
HumansPHPublic Health
-
Changes in Circulating B Cell Subsets Associated with Aging and Acute SIV Infection in Rhesus Macaques. PLoS One. 2017; 12(1):e0170154.
Chang WL, Gonzalez DF, Kieu HT, Castillo LD, Messaoudi I, Shen X, Tomaras GD, Shacklett BL, Barry PA, Sparger EE. PMID: 28095513; PMCID: PMC5240950.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
How common and frequent is heterosexual anal intercourse among South Africans? A systematic review and meta-analysis. J Int AIDS Soc. 2017 01 12; 19(1):21162.
Owen BN, Elmes J, Silhol R, Dang Q, McGowan I, Shacklett B, Swann EM, van der Straten A, Baggaley RF, Boily MC. PMID: 28364565; PMCID: PMC5461120.
View in:
PubMed Mentions:
12 Fields:
Translation:
Humans
-
Effects of depot-medroxyprogesterone acetate on the immune microenvironment of the human cervix and endometrium: implications for HIV susceptibility. Mucosal Immunol. 2017 09; 10(5):1270-1278.
Smith-McCune KK, Hilton JF, Shanmugasundaram U, Critchfield JW, Greenblatt RM, Seidman D, Averbach S, Giudice LC, Shacklett BL. PMID: 28051087; PMCID: PMC5496803.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
-
HIV persists in CCR6+CD4+ T cells from colon and blood during antiretroviral therapy. AIDS. 2017 01 02; 31(1):35-48.
Gosselin A, Wiche Salinas TR, Planas D, Wacleche VS, Zhang Y, Fromentin R, Chomont N, Cohen ÉA, Shacklett B, Mehraj V, Ghali MP, Routy JP, Ancuta P. PMID: 27835617; PMCID: PMC5131694.
View in:
PubMed Mentions:
87 Fields:
Translation:
HumansCells
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Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. Mucosal Immunol. 2017 07; 10(4):1008-1020.
Kiniry BE, Ganesh A, Critchfield JW, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL. PMID: 27827375; PMCID: PMC5423867.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansCells
-
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCellsCTClinical Trials
-
Cryopreservation of Human Mucosal Leukocytes. PLoS One. 2016; 11(5):e0156293.
Hughes SM, Shu Z, Levy CN, Ferre AL, Hartig H, Fang C, Lentz G, Fialkow M, Kirby AC, Adams Waldorf KM, Veazey RS, Germann A, von Briesen H, McElrath MJ, Dezzutti CS, Sinclair E, Baker CA, Shacklett BL, Gao D, Hladik F. PMID: 27232996; PMCID: PMC4883784.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Utilizing a TLR5-Adjuvanted Cytomegalovirus as a Lentiviral Vaccine in the Nonhuman Primate Model for AIDS. PLoS One. 2016; 11(5):e0155629.
Deere JD, Chang WL, Castillo LD, Schmidt KA, Kieu HT, Renzette N, Kowalik T, Barthold SW, Shacklett BL, Barry PA, Sparger EE. PMID: 27182601; PMCID: PMC4868283.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Immune Activation and HIV-Specific CD8(+) T Cells in Cerebrospinal Fluid of HIV Controllers and Noncontrollers. AIDS Res Hum Retroviruses. 2016 08; 32(8):791-800.
Ganesh A, Lemongello D, Lee E, Peterson J, McLaughlin BE, Ferre AL, Gillespie GM, Fuchs D, Deeks SG, Hunt PW, Price RW, Spudich SS, Shacklett BL. PMID: 27019338; PMCID: PMC4971411.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study. PLoS One. 2015; 10(7):e0129769.
Smith-McCune K, Chen JC, Greenblatt RM, Shanmugasundaram U, Shacklett BL, Hilton JF, Johnson B, Irwin JC, Giudice LC. PMID: 26177352; PMCID: PMC4503751.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
-
Cerebrospinal fluid (CSF) neuronal biomarkers across the spectrum of HIV infection: hierarchy of injury and detection. PLoS One. 2014; 9(12):e116081.
Peterson J, Gisslen M, Zetterberg H, Fuchs D, Shacklett BL, Hagberg L, Yiannoutsos CT, Spudich SS, Price RW. PMID: 25541953; PMCID: PMC4277428.
View in:
PubMed Mentions:
79 Fields:
Translation:
HumansCells
-
HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog. 2014 May; 10(5):e1004078.
Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG. PMID: 24831517; PMCID: PMC4022662.
View in:
PubMed Mentions:
311 Fields:
Translation:
HumansCells
-
Phenotype and functionality of CD4+ and CD8+ T cells in the upper reproductive tract of healthy premenopausal women. Am J Reprod Immunol. 2014 Feb; 71(2):95-108.
Shanmugasundaram U, Critchfield JW, Pannell J, Perry J, Giudice LC, Smith-McCune K, Greenblatt RM, Shacklett BL. PMID: 24313954; PMCID: PMC3947236.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Will loss of your MAITs weaken your HAART [corrected]? AIDS. 2013 10 23; 27(16):2501-4.
Sandberg JK, Dias J, Shacklett BL, Leeansyah E. PMID: 23595154; PMCID: PMC4004624.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCells
-
Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. PLoS Pathog. 2013; 9(10):e1003691.
Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG. PMID: 24130489; PMCID: PMC3795031.
View in:
PubMed Mentions:
68 Fields:
Translation:
HumansCellsCTClinical Trials
-
Single-copy assay quantification of HIV-1 RNA in paired cerebrospinal fluid and plasma samples from elite controllers. AIDS. 2013 Apr 24; 27(7):1145-9.
Dahl V, Peterson J, Spudich S, Lee E, Shacklett BL, Price RW, Palmer S. PMID: 23211774; PMCID: PMC4004626.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
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The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial. Blood. 2013 Jun 06; 121(23):4635-46.
Hunt PW, Shulman NS, Hayes TL, Dahl V, Somsouk M, Funderburg NT, McLaughlin B, Landay AL, Adeyemi O, Gilman LE, Clagett B, Rodriguez B, Martin JN, Schacker TW, Shacklett BL, Palmer S, Lederman MM, Deeks SG. PMID: 23589670; PMCID: PMC3685899.
View in:
PubMed Mentions:
79 Fields:
Translation:
HumansCells
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Impact of highly active antiretroviral therapy initiation on CD4(+) T-cell repopulation in duodenal and rectal mucosa. AIDS. 2013 Mar 27; 27(6):867-877.
Hayes TL, Asmuth DM, Critchfield JW, Knight TH, McLaughlin BE, Yotter T, McConnell DH, Garcia JC, Pollard RB, Shacklett BL. PMID: 23262500; PMCID: PMC4026034.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection. Blood. 2013 Feb 14; 121(7):1124-35.
Leeansyah E, Ganesh A, Quigley MF, Sönnerborg A, Andersson J, Hunt PW, Somsouk M, Deeks SG, Martin JN, Moll M, Shacklett BL, Sandberg JK. PMID: 23243281; PMCID: PMC3575756.
View in:
PubMed Mentions:
217 Fields:
Translation:
HumansCells
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Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation. AIDS Res Hum Retroviruses. 2013 Jan; 29(1):172-7.
Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL. PMID: 22998457; PMCID: PMC3537318.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection. BMC Complement Altern Med. 2012 Jun 29; 12:84.
Schunter M, Chu H, Hayes TL, McConnell D, Crawford SS, Luciw PA, Bengmark S, Asmuth DM, Brown J, Bevins CL, Shacklett BL, Critchfield JW. PMID: 22747752; PMCID: PMC3414771.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Myeloid dendritic cells isolated from tissues of SIV-infected Rhesus macaques promote the induction of regulatory T cells. AIDS. 2012 Jan 28; 26(3):263-73.
Presicce P, Shaw JM, Miller CJ, Shacklett BL, Chougnet CA. PMID: 22095196; PMCID: PMC3666583.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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T Cell Responses During Human Immunodeficiency Virus (HIV)-1 Infection. . 2012 Jan 1; 141-169.
Chougnet CC, Shacklett SB. .
View in:
Publisher Site Mentions:
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Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers. J Virol. 2011 Nov; 85(21):11422-34.
Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL. PMID: 21880771; PMCID: PMC3194952.
View in:
PubMed Mentions:
67 Fields:
Translation:
Cells
-
Mucosal immunity in HIV controllers: the right place at the right time. Curr Opin HIV AIDS. 2011 May; 6(3):202-7.
Shacklett BL, Ferre AL. PMID: 21399497; PMCID: PMC3245199.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansCells
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A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response. J Infect Dis. 2011 Apr 01; 203(7):960-8.
Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, Lampiris H, Hunt PW, Palmer S, McCune JM, Martin JN, Busch MP, Shacklett BL, Deeks SG. PMID: 21402547; PMCID: PMC3068029.
View in:
PubMed Mentions:
104 Fields:
Translation:
HumansCells
-
Immune responses to HIV in the female reproductive tract, immunologic parallels with the gastrointestinal tract, and research implications. Am J Reprod Immunol. 2011 Mar; 65(3):230-41.
Shacklett BL, Greenblatt RM. PMID: 21223420; PMCID: PMC3063101.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responses. J Virol. 2010 Nov; 84(21):11020-9.
Ferre AL, Hunt PW, McConnell DH, Morris MM, Garcia JC, Pollard RB, Yee HF, Martin JN, Deeks SG, Shacklett BL. PMID: 20719952; PMCID: PMC2953185.
View in:
PubMed Mentions:
69 Fields:
Translation:
HumansCells
-
Immunodominant HIV-specific CD8+ T-cell responses are common to blood and gastrointestinal mucosa, and Gag-specific responses dominate in rectal mucosa of HIV controllers. J Virol. 2010 Oct; 84(19):10354-65.
Ferre AL, Lemongello D, Hunt PW, Morris MM, Garcia JC, Pollard RB, Yee HF, Martin JN, Deeks SG, Shacklett BL. PMID: 20668079; PMCID: PMC2937770.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansCells
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Immune responses to HIV and SIV in mucosal tissues: 'location, location, location'. Curr Opin HIV AIDS. 2010 Mar; 5(2):128-34.
Shacklett BL. PMID: 20543589; PMCID: PMC2886278.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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HIV Infection and Gut Mucosal Immune Function: Updates on Pathogenesis with Implications for Management and Intervention. Curr Infect Dis Rep. 2010 Jan; 12(1):19-27.
Shacklett BL, Anton PA. PMID: 20174448; PMCID: PMC2821616.
View in:
PubMed Mentions:
33
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Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS. J Virol. 2010 Mar; 84(6):2913-22.
North TW, Higgins J, Deere JD, Hayes TL, Villalobos A, Adamson L, Shacklett BL, Schinazi RF, Luciw PA. PMID: 20032180; PMCID: PMC2826073.
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PubMed Mentions:
112 Fields:
Translation:
HumansAnimalsCells
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Cell-mediated immunity to HIV in the female reproductive tract. J Reprod Immunol. 2009 Dec; 83(1-2):190-5.
Shacklett BL. PMID: 19857902; PMCID: PMC2787994.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251. Virology. 2009 Mar 30; 386(1):109-21.
Dubie RA, Maksaereekul S, Shacklett BL, Lemongello D, Cole KS, Villinger F, Blozis SA, Luciw PA, Sparger EE. PMID: 19193388; PMCID: PMC3640844.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Quantifying HIV-1-specific CD8 (+) T-cell responses using ELISPOT and cytokine flow cytometry. Methods Mol Biol. 2009; 485:359-74.
Shacklett BL, Critchfield JW, Lemongello D. PMID: 19020837.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Isolating mucosal lymphocytes from biopsy tissue for cellular immunology assays. Methods Mol Biol. 2009; 485:347-56.
Shacklett BL, Critchfield JW, Lemongello D. PMID: 19020836.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Mucosal T-cell responses to HIV: responding at the front lines. J Intern Med. 2009 Jan; 265(1):58-66.
Shacklett BL, Critchfield JW, Ferre AL, Hayes TL. PMID: 19093960; PMCID: PMC2827148.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control. Blood. 2009 Apr 23; 113(17):3978-89.
Ferre AL, Hunt PW, Critchfield JW, Young DH, Morris MM, Garcia JC, Pollard RB, Yee HF, Martin JN, Deeks SG, Shacklett BL. PMID: 19109229; PMCID: PMC2673124.
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PubMed Mentions:
125 Fields:
Translation:
HumansCells
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Magnitude and complexity of rectal mucosa HIV-1-specific CD8+ T-cell responses during chronic infection reflect clinical status. PLoS One. 2008; 3(10):e3577.
Critchfield JW, Young DH, Hayes TL, Braun JV, Garcia JC, Pollard RB, Shacklett BL. PMID: 18974782; PMCID: PMC2570490.
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PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Mucosal immunity to HIV: a review of recent literature. Curr Opin HIV AIDS. 2008 Sep; 3(5):541-7.
Shacklett BL. PMID: 19373019; PMCID: PMC2659331.
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PubMed Mentions:
11 Fields:
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Nine-color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part II: Panel performance across different instrument platforms. Cytometry A. 2008 May; 73(5):411-20.
McLaughlin BE, Baumgarth N, Bigos M, Roederer M, De Rosa SC, Altman JD, Nixon DF, Ottinger J, Li J, Beckett L, Shacklett BL, Evans TG, Asmuth DM. PMID: 18383309; PMCID: PMC9191636.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control. J Virol. 2008 Jun; 82(11):5398-407.
Emu B, Sinclair E, Hatano H, Ferre A, Shacklett B, Martin JN, McCune JM, Deeks SG. PMID: 18353945; PMCID: PMC2395228.
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PubMed Mentions:
143 Fields:
Translation:
HumansCells
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Vaccination of rhesus macaques with a vif-deleted simian immunodeficiency virus proviral DNA vaccine. Virology. 2008 May 10; 374(2):261-72.
Sparger EE, Dubie RA, Shacklett BL, Cole KS, Chang WL, Luciw PA. PMID: 18261756; PMCID: PMC2519864.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCellsPHPublic Health
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Can the new humanized mouse model give HIV research a boost. PLoS Med. 2008 Jan 15; 5(1):e13.
Shacklett BL. PMID: 18198940; PMCID: PMC2194747.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Multifunctional human immunodeficiency virus (HIV) gag-specific CD8+ T-cell responses in rectal mucosa and peripheral blood mononuclear cells during chronic HIV type 1 infection. J Virol. 2007 Jun; 81(11):5460-71.
Critchfield JW, Lemongello D, Walker DH, Garcia JC, Asmuth DM, Pollard RB, Shacklett BL. PMID: 17344302; PMCID: PMC1900284.
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PubMed Mentions:
45 Fields:
Translation:
HumansCells
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Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection. J Virol. 2006 Aug; 80(16):8236-47.
Guadalupe M, Sankaran S, George MD, Reay E, Verhoeven D, Shacklett BL, Flamm J, Wegelin J, Prindiville T, Dandekar S. PMID: 16873279; PMCID: PMC1563811.
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PubMed Mentions:
131 Fields:
Translation:
HumansCells
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Understanding the "lucky few": The conundrum of HIV-exposed, seronegative individuals. Current Infectious Disease Reports. 2006 Jun 1; 8(3):248-253.
Shacklett SB. .
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Detection of macaque perforin expression and release by flow cytometry, immunohistochemistry, ELISA, and ELISpot. J Immunol Methods. 2006 May 30; 312(1-2):45-53.
Zuber B, Quigley MF, Critchfield JW, Shacklett BL, Abel K, Miller CJ, Mörner A, Paulie S, Ahlborg N, Sandberg JK. PMID: 16647080.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Perforin expression in the gastrointestinal mucosa is limited to acute simian immunodeficiency virus infection. J Virol. 2006 Mar; 80(6):3083-7.
Quigley MF, Abel K, Zuber B, Miller CJ, Sandberg JK, Shacklett BL. PMID: 16501118; PMCID: PMC1395471.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Understanding the "lucky few": the conundrum of HIV-exposed, seronegative individuals. Curr HIV/AIDS Rep. 2006 Feb; 3(1):26-31.
Shacklett BL. PMID: 16522256.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Seroconversion following nonoccupational postexposure prophylaxis against HIV. Clin Infect Dis. 2005 Nov 15; 41(10):1507-13.
Roland ME, Neilands TB, Krone MR, Katz MH, Franses K, Grant RM, Busch MP, Hecht FM, Shacklett BL, Kahn JO, Bamberger JD, Coates TJ, Chesney MA, Martin JN. PMID: 16231265.
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PubMed Mentions:
31 Fields:
Translation:
Humans
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Multidrug-resistant, dual-tropic HIV-1 and rapid progression. Lancet. 2005 Jun 4-10; 365(9475):1924-5.
Nixon DF, Deeks SG, Shacklett BL, Karlsson AC. PMID: 15936414.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection. J Immunol. 2004 Jul 01; 173(1):641-8.
Shacklett BL, Cox CA, Quigley MF, Kreis C, Stollman NH, Jacobson MA, Andersson J, Sandberg JK, Nixon DF. PMID: 15210827.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Increased adhesion molecule and chemokine receptor expression on CD8+ T cells trafficking to cerebrospinal fluid in HIV-1 infection. J Infect Dis. 2004 Jun 15; 189(12):2202-12.
Shacklett BL, Cox CA, Wilkens DT, Karl Karlsson R, Nilsson A, Nixon DF, Price RW. PMID: 15181567.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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Poorly soluble peptides can mimic authentic ELISPOT responses. J Immunol Methods. 2004 Feb 01; 285(1):89-92.
Karlsson RK, Jennes W, Page-Shafer K, Nixon DF, Shacklett BL. PMID: 14871537.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Limited magnitude and breadth in the HLA-A2-restricted CD8 T-Cell response to Nef in children with vertically acquired HIV-1 infection. Scand J Immunol. 2004 Jan; 59(1):109-14.
Chandwani R, Jordan KA, Shacklett BL, Papasavvas E, Montaner LJ, Rosenberg MG, Nixon DF, Sandberg JK. PMID: 14723629.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Optimization of methods to assess human mucosal T-cell responses to HIV infection. J Immunol Methods. 2003 Aug; 279(1-2):17-31.
Shacklett BL, Yang O, Hausner MA, Elliott J, Hultin L, Price C, Fuerst M, Matud J, Hultin P, Cox C, Ibarrondo J, Wong JT, Nixon DF, Anton PA, Jamieson BD. PMID: 12969544.
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PubMed Mentions:
65 Fields:
Translation:
HumansCells
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Trafficking of human immunodeficiency virus type 1-specific CD8+ T cells to gut-associated lymphoid tissue during chronic infection. J Virol. 2003 May; 77(10):5621-31.
Shacklett BL, Cox CA, Sandberg JK, Stollman NH, Jacobson MA, Nixon DF. PMID: 12719554; PMCID: PMC154016.
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PubMed Mentions:
45 Fields:
Translation:
HumansCells
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Enhanced ELISPOT detection of antigen-specific T cell responses from cryopreserved specimens with addition of both IL-7 and IL-15--the Amplispot assay. J Immunol Methods. 2002 Dec 01; 270(1):99-108.
Jennes W, Kestens L, Nixon DF, Shacklett BL. PMID: 12379342.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Live, attenuated simian immunodeficiency virus SIVmac-M4, with point mutations in the Env transmembrane protein intracytoplasmic domain, provides partial protection from mucosal challenge with pathogenic SIVmac251. J Virol. 2002 Nov; 76(22):11365-78.
Shacklett BL, Shaw KE, Adamson LA, Wilkens DT, Cox CA, Montefiori DC, Gardner MB, Sonigo P, Luciw PA. PMID: 12388697; PMCID: PMC136751.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCellsPHPublic Health
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Beyond 51Cr release: New methods for assessing HIV-1-specific CD8+ T cell responses in peripheral blood and mucosal tissues. Clin Exp Immunol. 2002 Nov; 130(2):172-82.
Shacklett BL. PMID: 12390303; PMCID: PMC1906532.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Boosting of SIV-specific T cell responses in rhesus macaques that resist repeated intravaginal challenge with SIVmac251. AIDS Res Hum Retroviruses. 2002 Sep 20; 18(14):1081-8.
Shacklett BL, Ling B, Veazey RS, Luckay A, Moretto WJ, Wilkens DT, Hu J, Israel ZR, Nixon DF, Marx PA. PMID: 12396459.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Dendritic cell amplification of HIV type 1-specific CD8+ T cell responses in exposed, seronegative heterosexual women. AIDS Res Hum Retroviruses. 2002 Jul 20; 18(11):805-15.
Shacklett BL, Means RE, Larsson M, Wilkens DT, Beadle TJ, Merritt MJ, Bhardwaj N, Palumbo PE, Skurnick JH, Louria DB, Nixon DF. PMID: 12167272.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Amplification of low-frequency antiviral CD8 T cell responses using autologous dendritic cells. AIDS. 2002 Jan 25; 16(2):171-80.
Larsson M, Wilkens DT, Fonteneau JF, Beadle TJ, Merritt MJ, Kost RG, Haslett PA, Cu-Uvin S, Bhardwaj N, Nixon DF, Shacklett BL. PMID: 11807300.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure. J Infect Dis. 2002 Feb 15; 185(4):428-38.
Skurnick JH, Palumbo P, DeVico A, Shacklett BL, Valentine FT, Merges M, Kamin-Lewis R, Mestecky J, Denny T, Lewis GK, Lloyd J, Praschunus R, Baker A, Nixon DF, Stranford S, Gallo R, Vermund SH, Louria DB. PMID: 11865394; PMCID: PMC2743095.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Direct ex vivo measurement of CD8(+) T-lymphocyte responses to human parvovirus B19. J Virol. 2001 Jan; 75(1):540-3.
Tolfvenstam T, Oxenius A, Price DA, Shacklett BL, Spiegel HM, Hedman K, Norbeck O, Levi M, Olsen K, Kantzanou M, Nixon DF, Broliden K, Klenerman P. PMID: 11119624; PMCID: PMC113948.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Quantification of HIV-1-specific T-cell responses at the mucosal cervicovaginal surface. AIDS. 2000 Sep 08; 14(13):1911-5.
Shacklett BL, Cu-Uvin S, Beadle TJ, Pace CA, Fast NM, Donahue SM, Caliendo AM, Flanigan TP, Carpenter CC, Nixon DF. PMID: 10997394.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Isolation of cytomegalovirus-specific cytotoxic T-lymphocytes from gut-associated lymphoid tissue (GALT) of HIV type 1-infected subjects. AIDS Res Hum Retroviruses. 2000 Aug 10; 16(12):1157-62.
Shacklett BL, Beadle TJ, Pacheco PA, Grendell JH, Haslett PA, King AS, Ogg GS, Basuk PM, Nixon DF. PMID: 10954891.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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The intracytoplasmic domain of the Env transmembrane protein is a locus for attenuation of simian immunodeficiency virus SIVmac in rhesus macaques. J Virol. 2000 Jul; 74(13):5836-44.
Shacklett BL, Weber CJ, Shaw KE, Keddie EM, Gardner MB, Sonigo P, Luciw PA. PMID: 10846063; PMCID: PMC112078.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Characterization of HIV-1-specific cytotoxic T lymphocytes expressing the mucosal lymphocyte integrin CD103 in rectal and duodenal lymphoid tissue of HIV-1-infected subjects. Virology. 2000 May 10; 270(2):317-27.
Shacklett BL, Beadle TJ, Pacheco PA, Grendell JH, Haslett PA, King AS, Ogg GS, Basuk PM, Nixon DF. PMID: 10792991.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins. J Virol. 1999 Feb; 73(2):1350-61.
Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R. PMID: 9882340; PMCID: PMC103959.
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PubMed Mentions:
95 Fields:
Translation:
HumansAnimalsCells
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Importance of the intracytoplasmic domain of the simian immunodeficiency virus (SIV) envelope glycoprotein for pathogenesis. Virology. 1998 Dec 05; 252(1):9-16.
Luciw PA, Shaw KE, Shacklett BL, Marthas ML. PMID: 9875311.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Features of the SIVmac transmembrane glycoprotein cytoplasmic domain that are important for Env functions. AIDS Res Hum Retroviruses. 1998 Mar 20; 14(5):373-83.
Shacklett BL, Denesvre C, Boson B, Sonigo P. PMID: 9546796.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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The rhesus macaque CCR3 chemokine receptor is a cell entry cofactor for HIV-2, but not for HIV-1. Virology. 1998 Jan 20; 240(2):213-20.
Sol N, Tréboute C, Gomas E, Ferchal F, Shacklett B, Alizon M. PMID: 9454694.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Analysis of the vif gene of feline immunodeficiency virus. Virology. 1994 Nov 01; 204(2):860-7.
Shacklett BL, Luciw PA. PMID: 7941360.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Antiviral studies of feline infectious peritonitis virus in vitro. Vet Rec. 1994 Aug 20; 135(8):177-9.
Barlough JE, Shacklett BL. PMID: 7992474.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Identification of the Rev transactivation and Rev-responsive elements of feline immunodeficiency virus. J Virol. 1992 Sep; 66(9):5464-71.
Phillips TR, Lamont C, Konings DA, Shacklett BL, Hamson CA, Luciw PA, Elder JH. PMID: 1323707; PMCID: PMC289103.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Regulation of gene expression directed by the long terminal repeat of the feline immunodeficiency virus. Virology. 1992 Mar; 187(1):165-77.
Sparger EE, Shacklett BL, Renshaw-Gegg L, Barry PA, Pedersen NC, Elder JH, Luciw PA. PMID: 1310554.
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PubMed Mentions:
49 Fields:
Translation:
Cells