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Barbara Shacklett

TitlePROF-HCOMP
InstitutionUniversity of California Davis
DepartmentMED:MEDICAL MICROBIOLOGY & IMM
AddressTupper Hall
CA 95616
Phone530-752-6785
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hughes SM, Ferre AL, Yandura SE, Shetler C, Baker CAR, Calienes F, Levy CN, Astronomo RD, Shu Z, Lentz GM, Fialkow M, Kirby AC, McElrath MJ, Sinclair E, Rohan LC, Anderson PL, Shacklett B, Dezzutti CS, Gao D, Hladik F. Cryopreservation of human mucosal tissues. PLoS One. 2018; 13(7):e0200653. PMID: 30059507.
      View in: PubMed
    2. Kiniry BE, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett B. Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection. J Immunol. 2018 Mar 01; 200(5):1876-1888. PMID: 29352005.
      View in: PubMed
    3. Kiniry BE, Li S, Ganesh A, Hunt PW, Somsouk M, Skinner PJ, Deeks SG, Shacklett B. Detection of HIV-1-specific gastrointestinal tissue resident CD8+ T-cells in chronic infection. Mucosal Immunol. 2017 Nov 15. PMID: 29139476.
      View in: PubMed
    4. Shacklett B, Derdeyn CA, Folayan MO, Landovitz RJ, Anthony C, Behrens AJ, Hope TJ, Landais E, Leal L, Marrazzo JM, Morris L, Mugo N, Ngure K, Noseda V, Ranasinghe S, Tully DC, Voronin Y, Warren M, Wibmer CK, Xie IY, Scarlatti G, Thyagarajan B. HIVR4P 2016, Partnering for Prevention: Conference Summary and Highlights. AIDS Res Hum Retroviruses. 2017 Aug; 33(8):749-759. PMID: 28649869.
      View in: PubMed
    5. Chang WL, Gonzalez DF, Kieu HT, Castillo LD, Messaoudi I, Shen X, Tomaras GD, Shacklett B, Barry PA, Sparger EE. Changes in Circulating B Cell Subsets Associated with Aging and Acute SIV Infection in Rhesus Macaques. PLoS One. 2017; 12(1):e0170154. PMID: 28095513.
      View in: PubMed
    6. Gosselin A, Wiche Salinas TR, Planas D, Wacleche VS, Zhang Y, Fromentin R, Chomont N, Cohen ÉA, Shacklett B, Mehraj V, Ghali MP, Routy JP, Ancuta P. HIV persists in CCR6+CD4+ T cells from colon and blood during antiretroviral therapy. AIDS. 2017 Jan 02; 31(1):35-48. PMID: 27835617.
      View in: PubMed
    7. Shanmugasundaram U, Hilton JF, Critchfield JW, Greenblatt RM, Giudice LC, Averbach S, Seidman D, Shacklett B, Smith-McCune K. Effects of the levonorgestrel-releasing intrauterine device on the immune microenvironment of the human cervix and endometrium. Am J Reprod Immunol. 2016 08; 76(2):137-48. PMID: 27401588.
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    8. Hughes SM, Shu Z, Levy CN, Ferre AL, Hartig H, Fang C, Lentz G, Fialkow M, Kirby AC, Adams Waldorf KM, Veazey RS, Germann A, von Briesen H, McElrath MJ, Dezzutti CS, Sinclair E, Baker CA, Shacklett B, Gao D, Hladik F. Cryopreservation of Human Mucosal Leukocytes. PLoS One. 2016; 11(5):e0156293. PMID: 27232996; PMCID: PMC4883784.
    9. Deere JD, Chang WL, Castillo LD, Schmidt KA, Kieu HT, Renzette N, Kowalik T, Barthold SW, Shacklett B, Barry PA, Sparger EE. Utilizing a TLR5-Adjuvanted Cytomegalovirus as a Lentiviral Vaccine in the Nonhuman Primate Model for AIDS. PLoS One. 2016; 11(5):e0155629. PMID: 27182601.
      View in: PubMed
    10. Ganesh A, Lemongello D, Lee E, Peterson J, McLaughlin BE, Ferre AL, Gillespie GM, Fuchs D, Deeks SG, Hunt PW, Price RW, Spudich SS, Shacklett B. Immune Activation and HIV-Specific CD8(+) T Cells in Cerebrospinal Fluid of HIV Controllers and Noncontrollers. AIDS Res Hum Retroviruses. 2016 08; 32(8):791-800. PMID: 27019338.
      View in: PubMed
    11. Smith-McCune K, Chen JC, Greenblatt RM, Shanmugasundaram U, Shacklett B, Hilton JF, Johnson B, Irwin JC, Giudice LC. Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study. PLoS One. 2015; 10(7):e0129769. PMID: 26177352; PMCID: PMC4503751.
    12. Peterson J, Gisslen M, Zetterberg H, Fuchs D, Shacklett B, Hagberg L, Yiannoutsos CT, Spudich SS, Price RW. Cerebrospinal fluid (CSF) neuronal biomarkers across the spectrum of HIV infection: hierarchy of injury and detection. PLoS One. 2014; 9(12):e116081. PMID: 25541953; PMCID: PMC4277428.
    13. Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett B, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog. 2014 May; 10(5):e1004078. PMID: 24831517; PMCID: PMC4022662.
    14. Shanmugasundaram U, Critchfield JW, Pannell J, Perry J, Giudice LC, Smith-McCune K, Greenblatt RM, Shacklett B. Phenotype and functionality of CD4+ and CD8+ T cells in the upper reproductive tract of healthy premenopausal women. Am J Reprod Immunol. 2014 Feb; 71(2):95-108. PMID: 24313954; PMCID: PMC3947236.
    15. Sandberg JK, Dias J, Shacklett B, Leeansyah E. Will loss of your MAITs weaken your HAART [corrected]? AIDS. 2013 Oct 23; 27(16):2501-4. PMID: 23595154; PMCID: PMC4004624.
    16. Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett B, Wong JK, Deeks SG. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. PLoS Pathog. 2013; 9(10):e1003691. PMID: 24130489; PMCID: PMC3795031.
    17. Dahl V, Peterson J, Spudich S, Lee E, Shacklett B, Price RW, Palmer S. Single-copy assay quantification of HIV-1 RNA in paired cerebrospinal fluid and plasma samples from elite controllers. AIDS. 2013 Apr 24; 27(7):1145-9. PMID: 23211774; PMCID: PMC4004626.
    18. Hunt PW, Shulman NS, Hayes TL, Dahl V, Somsouk M, Funderburg NT, McLaughlin B, Landay AL, Adeyemi O, Gilman LE, Clagett B, Rodriguez B, Martin JN, Schacker TW, Shacklett B, Palmer S, Lederman MM, Deeks SG. The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial. Blood. 2013 Jun 06; 121(23):4635-46. PMID: 23589670; PMCID: PMC3685899.
    19. Hayes TL, Asmuth DM, Critchfield JW, Knight TH, McLaughlin BE, Yotter T, McConnell DH, Garcia JC, Pollard RB, Shacklett B. Impact of highly active antiretroviral therapy initiation on CD4(+) T-cell repopulation in duodenal and rectal mucosa. AIDS. 2013 Mar 27; 27(6):867-77. PMID: 23262500; PMCID: PMC4026034.
    20. Leeansyah E, Ganesh A, Quigley MF, Sönnerborg A, Andersson J, Hunt PW, Somsouk M, Deeks SG, Martin JN, Moll M, Shacklett B, Sandberg JK. Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection. Blood. 2013 Feb 14; 121(7):1124-35. PMID: 23243281; PMCID: PMC3575756.
    21. Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett B. Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation. AIDS Res Hum Retroviruses. 2013 Jan; 29(1):172-7. PMID: 22998457; PMCID: PMC3537318.
    22. Schunter M, Chu H, Hayes TL, McConnell D, Crawford SS, Luciw PA, Bengmark S, Asmuth DM, Brown J, Bevins CL, Shacklett B, Critchfield JW. Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection. BMC Complement Altern Med. 2012 Jun 29; 12:84. PMID: 22747752; PMCID: PMC3414771.
    23. Presicce P, Shaw JM, Miller CJ, Shacklett B, Chougnet CA. Myeloid dendritic cells isolated from tissues of SIV-infected Rhesus macaques promote the induction of regulatory T cells. AIDS. 2012 Jan 28; 26(3):263-73. PMID: 22095196; PMCID: PMC3666583.
    24. Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett B. Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers. J Virol. 2011 Nov; 85(21):11422-34. PMID: 21880771; PMCID: PMC3194952.
    25. Shacklett B, Ferre AL. Mucosal immunity in HIV controllers: the right place at the right time. Curr Opin HIV AIDS. 2011 May; 6(3):202-7. PMID: 21399497; PMCID: PMC3245199.
    26. Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, Lampiris H, Hunt PW, Palmer S, McCune JM, Martin JN, Busch MP, Shacklett B, Deeks SG. A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response. J Infect Dis. 2011 Apr 01; 203(7):960-8. PMID: 21402547; PMCID: PMC3068029.
    27. Shacklett B, Greenblatt RM. Immune responses to HIV in the female reproductive tract, immunologic parallels with the gastrointestinal tract, and research implications. Am J Reprod Immunol. 2011 Mar; 65(3):230-41. PMID: 21223420; PMCID: PMC3063101.
    28. Ferre AL, Hunt PW, McConnell DH, Morris MM, Garcia JC, Pollard RB, Yee HF, Martin JN, Deeks SG, Shacklett B. HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responses. J Virol. 2010 Nov; 84(21):11020-9. PMID: 20719952; PMCID: PMC2953185.
    29. Ferre AL, Lemongello D, Hunt PW, Morris MM, Garcia JC, Pollard RB, Yee HF, Martin JN, Deeks SG, Shacklett B. Immunodominant HIV-specific CD8+ T-cell responses are common to blood and gastrointestinal mucosa, and Gag-specific responses dominate in rectal mucosa of HIV controllers. J Virol. 2010 Oct; 84(19):10354-65. PMID: 20668079; PMCID: PMC2937770.
    30. Shacklett B. Immune responses to HIV and SIV in mucosal tissues: 'location, location, location'. Curr Opin HIV AIDS. 2010 Mar; 5(2):128-34. PMID: 20543589; PMCID: PMC2886278.
    31. Shacklett B, Anton PA. HIV Infection and Gut Mucosal Immune Function: Updates on Pathogenesis with Implications for Management and Intervention. Curr Infect Dis Rep. 2010 Jan; 12(1):19-27. PMID: 20174448.
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    32. North TW, Higgins J, Deere JD, Hayes TL, Villalobos A, Adamson L, Shacklett B, Schinazi RF, Luciw PA. Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS. J Virol. 2010 Mar; 84(6):2913-22. PMID: 20032180; PMCID: PMC2826073.
    33. Shacklett B. Cell-mediated immunity to HIV in the female reproductive tract. J Reprod Immunol. 2009 Dec; 83(1-2):190-5. PMID: 19857902; PMCID: PMC2787994.
    34. Dubie RA, Maksaereekul S, Shacklett B, Lemongello D, Cole KS, Villinger F, Blozis SA, Luciw PA, Sparger EE. Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251. Virology. 2009 Mar 30; 386(1):109-21. PMID: 19193388; PMCID: PMC3640844.
    35. Shacklett B, Critchfield JW, Lemongello D. Quantifying HIV-1-specific CD8 (+) T-cell responses using ELISPOT and cytokine flow cytometry. Methods Mol Biol. 2009; 485:359-74. PMID: 19020837.
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    36. Shacklett B, Critchfield JW, Lemongello D. Isolating mucosal lymphocytes from biopsy tissue for cellular immunology assays. Methods Mol Biol. 2009; 485:347-56. PMID: 19020836.
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    37. Shacklett B, Critchfield JW, Ferre AL, Hayes TL. Mucosal T-cell responses to HIV: responding at the front lines. J Intern Med. 2009 Jan; 265(1):58-66. PMID: 19093960; PMCID: PMC2827148.
    38. Ferre AL, Hunt PW, Critchfield JW, Young DH, Morris MM, Garcia JC, Pollard RB, Yee HF, Martin JN, Deeks SG, Shacklett B. Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control. Blood. 2009 Apr 23; 113(17):3978-89. PMID: 19109229; PMCID: PMC2673124.
    39. Critchfield JW, Young DH, Hayes TL, Braun JV, Garcia JC, Pollard RB, Shacklett B. Magnitude and complexity of rectal mucosa HIV-1-specific CD8+ T-cell responses during chronic infection reflect clinical status. PLoS One. 2008; 3(10):e3577. PMID: 18974782; PMCID: PMC2570490.
    40. Shacklett B. Mucosal immunity to HIV: a review of recent literature. Curr Opin HIV AIDS. 2008 Sep; 3(5):541-7. PMID: 19373019; PMCID: PMC2659331.
    41. McLaughlin BE, Baumgarth N, Bigos M, Roederer M, De Rosa SC, Altman JD, Nixon DF, Ottinger J, Li J, Beckett L, Shacklett B, Evans TG, Asmuth DM. Nine-color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part II: Panel performance across different instrument platforms. Cytometry A. 2008 May; 73(5):411-20. PMID: 18383309.
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    42. Emu B, Sinclair E, Hatano H, Ferre A, Shacklett B, Martin JN, McCune JM, Deeks SG. HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control. J Virol. 2008 Jun; 82(11):5398-407. PMID: 18353945; PMCID: PMC2395228.
    43. Sparger EE, Dubie RA, Shacklett B, Cole KS, Chang WL, Luciw PA. Vaccination of rhesus macaques with a vif-deleted simian immunodeficiency virus proviral DNA vaccine. Virology. 2008 May 10; 374(2):261-72. PMID: 18261756; PMCID: PMC2519864.
    44. Shacklett B. Can the new humanized mouse model give HIV research a boost. PLoS Med. 2008 Jan 15; 5(1):e13. PMID: 18198940; PMCID: PMC2194747.
    45. Critchfield JW, Lemongello D, Walker DH, Garcia JC, Asmuth DM, Pollard RB, Shacklett B. Multifunctional human immunodeficiency virus (HIV) gag-specific CD8+ T-cell responses in rectal mucosa and peripheral blood mononuclear cells during chronic HIV type 1 infection. J Virol. 2007 Jun; 81(11):5460-71. PMID: 17344302; PMCID: PMC1900284.
    46. Guadalupe M, Sankaran S, George MD, Reay E, Verhoeven D, Shacklett B, Flamm J, Wegelin J, Prindiville T, Dandekar S. Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection. J Virol. 2006 Aug; 80(16):8236-47. PMID: 16873279; PMCID: PMC1563811.
    47. Zuber B, Quigley MF, Critchfield JW, Shacklett B, Abel K, Miller CJ, Mörner A, Paulie S, Ahlborg N, Sandberg JK. Detection of macaque perforin expression and release by flow cytometry, immunohistochemistry, ELISA, and ELISpot. J Immunol Methods. 2006 May 30; 312(1-2):45-53. PMID: 16647080.
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    48. Quigley MF, Abel K, Zuber B, Miller CJ, Sandberg JK, Shacklett B. Perforin expression in the gastrointestinal mucosa is limited to acute simian immunodeficiency virus infection. J Virol. 2006 Mar; 80(6):3083-7. PMID: 16501118; PMCID: PMC1395471.
    49. Shacklett B. Understanding the "lucky few": the conundrum of HIV-exposed, seronegative individuals. Curr HIV/AIDS Rep. 2006 Feb; 3(1):26-31. PMID: 16522256.
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    50. Nixon DF, Deeks SG, Shacklett B, Karlsson AC. Multidrug-resistant, dual-tropic HIV-1 and rapid progression. Lancet. 2005 Jun 4-10; 365(9475):1924-5. PMID: 15936414.
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    51. Shacklett B, Cox CA, Quigley MF, Kreis C, Stollman NH, Jacobson MA, Andersson J, Sandberg JK, Nixon DF. Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection. J Immunol. 2004 Jul 01; 173(1):641-8. PMID: 15210827.
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    52. Shacklett B, Cox CA, Wilkens DT, Karl Karlsson R, Nilsson A, Nixon DF, Price RW. Increased adhesion molecule and chemokine receptor expression on CD8+ T cells trafficking to cerebrospinal fluid in HIV-1 infection. J Infect Dis. 2004 Jun 15; 189(12):2202-12. PMID: 15181567.
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    53. Karlsson RK, Jennes W, Page-Shafer K, Nixon DF, Shacklett B. Poorly soluble peptides can mimic authentic ELISPOT responses. J Immunol Methods. 2004 Feb 01; 285(1):89-92. PMID: 14871537.
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    54. Shacklett B, Yang O, Hausner MA, Elliott J, Hultin L, Price C, Fuerst M, Matud J, Hultin P, Cox C, Ibarrondo J, Wong JT, Nixon DF, Anton PA, Jamieson BD. Optimization of methods to assess human mucosal T-cell responses to HIV infection. J Immunol Methods. 2003 Aug; 279(1-2):17-31. PMID: 12969544.
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    55. Shacklett B, Cox CA, Sandberg JK, Stollman NH, Jacobson MA, Nixon DF. Trafficking of human immunodeficiency virus type 1-specific CD8+ T cells to gut-associated lymphoid tissue during chronic infection. J Virol. 2003 May; 77(10):5621-31. PMID: 12719554; PMCID: PMC154016.
    56. Jennes W, Kestens L, Nixon DF, Shacklett B. Enhanced ELISPOT detection of antigen-specific T cell responses from cryopreserved specimens with addition of both IL-7 and IL-15--the Amplispot assay. J Immunol Methods. 2002 Dec 01; 270(1):99-108. PMID: 12379342.
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    57. Shacklett B, Shaw KE, Adamson LA, Wilkens DT, Cox CA, Montefiori DC, Gardner MB, Sonigo P, Luciw PA. Live, attenuated simian immunodeficiency virus SIVmac-M4, with point mutations in the Env transmembrane protein intracytoplasmic domain, provides partial protection from mucosal challenge with pathogenic SIVmac251. J Virol. 2002 Nov; 76(22):11365-78. PMID: 12388697; PMCID: PMC136751.
    58. Shacklett B, Ling B, Veazey RS, Luckay A, Moretto WJ, Wilkens DT, Hu J, Israel ZR, Nixon DF, Marx PA. Boosting of SIV-specific T cell responses in rhesus macaques that resist repeated intravaginal challenge with SIVmac251. AIDS Res Hum Retroviruses. 2002 Sep 20; 18(14):1081-8. PMID: 12396459.
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    59. Shacklett B, Means RE, Larsson M, Wilkens DT, Beadle TJ, Merritt MJ, Bhardwaj N, Palumbo PE, Skurnick JH, Louria DB, Nixon DF. Dendritic cell amplification of HIV type 1-specific CD8+ T cell responses in exposed, seronegative heterosexual women. AIDS Res Hum Retroviruses. 2002 Jul 20; 18(11):805-15. PMID: 12167272.
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    60. Larsson M, Wilkens DT, Fonteneau JF, Beadle TJ, Merritt MJ, Kost RG, Haslett PA, Cu-Uvin S, Bhardwaj N, Nixon DF, Shacklett B. Amplification of low-frequency antiviral CD8 T cell responses using autologous dendritic cells. AIDS. 2002 Jan 25; 16(2):171-80. PMID: 11807300.
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    61. Skurnick JH, Palumbo P, DeVico A, Shacklett B, Valentine FT, Merges M, Kamin-Lewis R, Mestecky J, Denny T, Lewis GK, Lloyd J, Praschunus R, Baker A, Nixon DF, Stranford S, Gallo R, Vermund SH, Louria DB. Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure. J Infect Dis. 2002 Feb 15; 185(4):428-38. PMID: 11865394; PMCID: PMC2743095.