Ellen Elizabeth Sparger

Title(s)Professor, School of Veterinary Medicine
SchoolUniversity of California, Davis
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    CMV-vectored Vaccine Approaches to Induce Protective Antibodies to HIV-1 Env
    NIH/NIAID R21AI134618Jun 26, 2017 - May 31, 2019
    Role: Co-Principal Investigator
    Impact of chronic viral infections and altered microbiota on HIV vaccine efficacy
    NIH R56AI120739Jun 18, 2015 - May 31, 2017
    Role: Co-Principal Investigator
    Attenuated RhCMV Delta 10 SIV Oral Vaccine Vectors Encoding TLR5 Ligand Sequences
    NIH R01DE021273Dec 1, 2010 - Nov 30, 2016
    Role: Principal Investigator
    Development and Immunogenicity of Attenuated RhCMVdelta10 Vaccine Vectors
    NIH/NIAID R21AI088471Jun 15, 2010 - May 31, 2013
    Role: Principal Investigator
    Cellular Immune Responses Induced by SIVdelta-vif plus IL-15 DNA Vaccine
    NIH/NIAID R03AI076091Sep 17, 2008 - Aug 31, 2010
    Role: Principal Investigator
    SIV Deltavif Reservoirs in Vivo
    NIH/NIAID R21AI068654Jul 1, 2006 - Jun 30, 2008
    Role: Principal Investigator
    Feline Immunodeficiency Virus Orf-A A Model for HIV Vpr
    NIH/NIAID R01AI057037Feb 15, 2004 - Jan 31, 2008
    Role: Principal Investigator
    SIV delta vif DNA Vaccines with Cytokine Adjuvants
    NIH/NIAID R01AI054204Jan 16, 2003 - Dec 31, 2005
    Role: Principal Investigator
    HIGHLY ATTENUATED SIV VIF DNA VACCINES
    NIH/NIAID R01AI049703Sep 29, 2000 - Aug 31, 2002
    Role: Principal Investigator
    REGULATED FIV VECTORS FOR VACCINATION
    NIH/NIAID R21AI046306Sep 1, 1999 - Aug 31, 2001
    Role: Principal Investigator
    INTERACTIONS OF FIV ORF-A GENE AND AIDS PATHOGENESIS
    NIH/NIAID R21AI046276Jul 1, 1999 - Jun 30, 2000
    Role: Principal Investigator
    FIVDELTAVIF DNA Vaccines with Cytokine Adjuvants
    NIH/NIAID R01AI040896Jun 1, 1997 - May 31, 2006
    Role: Principal Investigator
    FELINE IMMUNODEFICIENCY VIRUS LTR MUTANTS INFECTION
    NIH/NIAID R29AI034776Jul 15, 1993 - Jun 30, 1998
    Role: Principal Investigator
    CHARACTERIZATION OF THE FELINE T LYMPHOTROPHIC VIRUS
    NIH/NIAID F32AI007827Aug 31, 1988
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. T Cell Immune Profiles of Blood and Tumor in Dogs Diagnosed With Malignant Melanoma. Front Vet Sci. 2021; 8:772932. Sparger EE, Chang H, Chin N, Rebhun RB, Withers SS, Kieu H, Canter RJ, Monjazeb AM, Kent MS. PMID: 34926643; PMCID: PMC8674490.
      View in: PubMed   Mentions:
    2. RhCMV serostatus and vaccine adjuvant impact immunogenicity of RhCMV/SIV vaccines. Sci Rep. 2020 08 20; 10(1):14056. Chang WLW, Deere JD, Kieu HT, Castillo LD, Machmach K, Shen X, Tomaras GD, Shacklett BL, Barry PA, Hartigan-O'Connor DJ, Sparger EE. PMID: 32820216; PMCID: PMC7441386.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Development of canine PD-1/PD-L1 specific monoclonal antibodies and amplification of canine T cell function. PLoS One. 2020; 15(7):e0235518. Choi JW, Withers SS, Chang H, Spanier JA, De La Trinidad VL, Panesar H, Fife BT, Sciammas R, Sparger EE, Moore PF, Kent MS, Rebhun RB, McSorley SJ. PMID: 32614928; PMCID: PMC7332054.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Cytomegalovirus-vectored vaccines for HIV and other pathogens. AIDS. 2020 03 01; 34(3):335-349. Barry PA, Deere JD, Yue Y, Chang WWL, Schmidt KA, Wussow F, Chiuppesi F, Diamond DJ, Sparger EE, Walter MR, Hartigan-O'Connor DJ. PMID: 31634191; PMCID: PMC7087350.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. The effects of local irradiation on circulating lymphocytes in dogs receiving fractionated radiotherapy. Vet Comp Oncol. 2020 Jun; 18(2):191-198. Kent MS, Emami S, Rebhun R, Theon A, Hansen K, Sparger E. PMID: 31424596.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Characterization of antiviral T cell responses during primary and secondary challenge of laboratory cats with feline infectious peritonitis virus (FIPV). BMC Vet Res. 2019 May 22; 15(1):165. Mustaffa-Kamal F, Liu H, Pedersen NC, Sparger EE. PMID: 31118053; PMCID: PMC6532132.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. Metastatic immune infiltrates correlate with those of the primary tumour in canine osteosarcoma. Vet Comp Oncol. 2019 Sep; 17(3):242-252. Withers SS, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Burton JH, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB. PMID: 30684301; PMCID: PMC6658355.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma. Vet Comp Oncol. 2019 Mar; 17(1):49-60. Withers SS, Skorupski KA, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Rodriguez CO, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB. PMID: 30156029; PMCID: PMC6363827.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    9. Subclinical Cytomegalovirus Infection Is Associated with Altered Host Immunity, Gut Microbiota, and Vaccine Responses. J Virol. 2018 07 01; 92(13). Santos Rocha C, Hirao LA, Weber MG, Méndez-Lagares G, Chang WLW, Jiang G, Deere JD, Sparger EE, Roberts J, Barry PA, Hartigan-O'Connor DJ, Dandekar S. PMID: 29669841; PMCID: PMC6002712.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    10. Investigation of immune cell markers in feline oral squamous cell carcinoma. Vet Immunol Immunopathol. 2018 Aug; 202:52-62. Sparger EE, Murphy BG, Kamal FM, Arzi B, Naydan D, Skouritakis CT, Cox DP, Skorupski K. PMID: 30078599; PMCID: PMC6484848.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs. Dev Comp Immunol. 2018 10; 87:64-74. Withers SS, Moore PF, Chang H, Choi JW, McSorley SJ, Kent MS, Monjazeb AM, Canter RJ, Murphy WJ, Sparger EE, Rebhun RB. PMID: 29859828; PMCID: PMC6197816.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Central and peripheral reservoirs of feline immunodeficiency virus in cats: a review. J Gen Virol. 2017 Aug; 98(8):1985-1996. Eckstrand CD, Sparger EE, Murphy BG. PMID: 28749325.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Changes in Circulating B Cell Subsets Associated with Aging and Acute SIV Infection in Rhesus Macaques. PLoS One. 2017; 12(1):e0170154. Chang WL, Gonzalez DF, Kieu HT, Castillo LD, Messaoudi I, Shen X, Tomaras GD, Shacklett BL, Barry PA, Sparger EE. PMID: 28095513; PMCID: PMC5240950.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. Canine cancer immunotherapy studies: linking mouse and human. J Immunother Cancer. 2016; 4:97. Park JS, Withers SS, Modiano JF, Kent MS, Chen M, Luna JI, Culp WTN, Sparger EE, Rebhun RB, Monjazeb AM, Murphy WJ, Canter RJ. PMID: 28031824; PMCID: PMC5171656.
      View in: PubMed   Mentions: 39     Fields:    
    15. Utilizing a TLR5-Adjuvanted Cytomegalovirus as a Lentiviral Vaccine in the Nonhuman Primate Model for AIDS. PLoS One. 2016; 11(5):e0155629. Deere JD, Chang WL, Castillo LD, Schmidt KA, Kieu HT, Renzette N, Kowalik T, Barthold SW, Shacklett BL, Barry PA, Sparger EE. PMID: 27182601; PMCID: PMC4868283.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Antitumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies. Clin Cancer Res. 2016 Sep 01; 22(17):4328-40. Monjazeb AM, Kent MS, Grossenbacher SK, Mall C, Zamora AE, Mirsoian A, Chen M, Kol A, Shiao SL, Reddy A, Perks JR, T N Culp W, Sparger EE, Canter RJ, Sckisel GD, Murphy WJ. PMID: 26979392; PMCID: PMC5010514.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    17. Feline immunodeficiency virus latency. Retrovirology. 2013 Jul 06; 10:69. McDonnel SJ, Sparger EE, Murphy BG. PMID: 23829177; PMCID: PMC3707804.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    18. Pharmacologic reactivation of latent feline immunodeficiency virus ex vivo in peripheral CD4+ T-lymphocytes. Virus Res. 2012 Dec; 170(1-2):174-9. McDonnel SJ, Sparger EE, Luciw PA, Murphy BG. PMID: 23073179; PMCID: PMC3513637.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    19. Transcriptional regulation of latent feline immunodeficiency virus in peripheral CD4+ T-lymphocytes. Viruses. 2012 05; 4(5):878-88. McDonnel SJ, Sparger EE, Luciw PA, Murphy BG. PMID: 22754653; PMCID: PMC3386631.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    20. FIV establishes a latent infection in feline peripheral blood CD4+ T lymphocytes in vivo during the asymptomatic phase of infection. Retrovirology. 2012 Feb 07; 9:12. Murphy B, Vapniarsky N, Hillman C, Castillo D, McDonnel S, Moore P, Luciw PA, Sparger EE. PMID: 22314004; PMCID: PMC3292463.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    21. Exploiting the natural history of cytomegalovirus to vaccinate against HIV. Expert Rev Vaccines. 2009 Aug; 8(8):993-7. Sparger EE, Gardner MB, Barry PA. PMID: 19627183.
      View in: PubMed   Mentions:    Fields:    
    22. Vaccination with vif-deleted feline immunodeficiency virus provirus, GM-CSF, and TNF-alpha plasmids preserves global CD4 T lymphocyte function after challenge with FIV. Vaccine. 2009 Jun 08; 27(28):3754-65. Maksaereekul S, Dubie RA, Shen X, Kieu H, Dean GA, Sparger EE. PMID: 19464559; PMCID: PMC2802579.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251. Virology. 2009 Mar 30; 386(1):109-21. Dubie RA, Maksaereekul S, Shacklett BL, Lemongello D, Cole KS, Villinger F, Blozis SA, Luciw PA, Sparger EE. PMID: 19193388; PMCID: PMC3640844.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    24. Vaccination of rhesus macaques with a vif-deleted simian immunodeficiency virus proviral DNA vaccine. Virology. 2008 May 10; 374(2):261-72. Sparger EE, Dubie RA, Shacklett BL, Cole KS, Chang WL, Luciw PA. PMID: 18261756; PMCID: PMC2519864.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    25. A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens. J Gen Virol. 2007 Oct; 88(Pt 10):2793-2799. Shen X, Leutenegger CM, Stefano Cole K, Pedersen NC, Sparger EE. PMID: 17872533.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    26. Vaccination of cats with attenuated feline immunodeficiency virus proviral DNA vaccine expressing gamma interferon. J Virol. 2007 Jan; 81(2):465-73. Gupta S, Leutenegger CM, Dean GA, Steckbeck JD, Cole KS, Sparger EE. PMID: 17079309; PMCID: PMC1797444.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    27. Construction and characterization of feline immunodeficiency virus proviral mutants that coexpress interferon gamma and green fluorescent protein. AIDS Res Hum Retroviruses. 2006 Apr; 22(4):342-9. Gupta S, Leutenegger C, Dean G, Sparger E. PMID: 16623638.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    28. Feline immunodeficiency virus Orf-A localizes to the nucleus and induces cell cycle arrest. Virology. 2004 Aug 01; 325(2):167-74. Gemeniano MC, Sawai ET, Sparger EE. PMID: 15246256.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    29. Feline immunodeficiency virus ORF-Ais required for virus particle formation and virus infectivity. J Virol. 2003 Aug; 77(16):8819-30. Gemeniano MC, Sawai ET, Leutenegger CM, Sparger EE. PMID: 12885901; PMCID: PMC167212.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    30. Infection of cats by injection with DNA of a feline immunodeficiency virus molecular clone. Virology. 1997 Nov 10; 238(1):157-60. Sparger EE, Louie H, Ziomeck AM, Luciw PA. PMID: 9375019.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells