Ellen E Sparger

InstitutionUniversity of California Davis
DepartmentMedicine and Epidemiology
CA 95616
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    Collapse Research 
    Collapse Research Activities and Funding
    CMV-vectored Vaccine Approaches to Induce Protective Antibodies to HIV-1 Env
    NIH/NIAID R21AI134618Jun 26, 2017 - May 31, 2019
    Role: Co-Principal Investigator
    Impact of chronic viral infections and altered microbiota on HIV vaccine efficacy
    NIH/NIAID R56AI120739Jun 18, 2015 - May 31, 2016
    Role: Co-Principal Investigator
    Attenuated RhCMV Delta 10 SIV Oral Vaccine Vectors Encoding TLR5 Ligand Sequences
    NIH/NIDCR R01DE021273Dec 1, 2010 - Nov 30, 2015
    Role: Principal Investigator
    Development and Immunogenicity of Attenuated RhCMVdelta10 Vaccine Vectors
    NIH/NIAID R21AI088471Jun 15, 2010 - May 31, 2013
    Role: Principal Investigator
    Cellular Immune Responses Induced by SIVdelta-vif plus IL-15 DNA Vaccine
    NIH/NIAID R03AI076091Sep 17, 2008 - Aug 31, 2010
    Role: Principal Investigator
    SIV Deltavif Reservoirs in Vivo
    NIH/NIAID R21AI068654Jul 1, 2006 - Jun 30, 2008
    Role: Principal Investigator
    Feline Immunodeficiency Virus Orf-A A Model for HIV Vpr
    NIH/NIAID R01AI057037Feb 15, 2004 - Jan 31, 2008
    Role: Principal Investigator
    SIV delta vif DNA Vaccines with Cytokine Adjuvants
    NIH/NIAID R01AI054204Jan 16, 2003 - Dec 31, 2005
    Role: Principal Investigator
    NIH/NIAID R01AI049703Sep 29, 2000 - Aug 31, 2002
    Role: Principal Investigator
    NIH/NIAID R21AI046306Sep 1, 1999 - Aug 31, 2001
    Role: Principal Investigator
    NIH/NIAID R21AI046276Jul 1, 1999 - Jun 30, 2000
    Role: Principal Investigator
    FIVDELTAVIF DNA Vaccines with Cytokine Adjuvants
    NIH/NIAID R01AI040896Jun 1, 1997 - May 31, 2006
    Role: Principal Investigator
    NIH/NIAID R29AI034776Jul 15, 1993 - Jun 30, 1998
    Role: Principal Investigator
    NIH/NIAID F32AI007827Aug 31, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Withers SS, Skorupski KA, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Rodriguez CO, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB. Association of Macrophage and Lymphocyte Infiltration with Outcome in Canine Osteosarcoma. Vet Comp Oncol. 2018 Aug 28. PMID: 30156029.
      View in: PubMed
    2. Sparger EE, Murphy BG, Kamal FM, Arzi B, Naydan D, Skouritakis CT, Cox DP, Skorupski K. Investigation of immune cell markers in feline oral squamous cell carcinoma. Vet Immunol Immunopathol. 2018 Aug; 202:52-62. PMID: 30078599.
      View in: PubMed
    3. Withers SS, Moore PF, Chang H, Choi JW, McSorley SJ, Kent MS, Monjazeb AM, Canter RJ, Murphy WJ, Sparger EE, Rebhun RB. Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs. Dev Comp Immunol. 2018 May 31; 87:64-74. PMID: 29859828.
      View in: PubMed
    4. Santos Rocha C, Hirao LA, Weber MG, Méndez-Lagares G, Chang WLW, Jiang G, Deere JD, Sparger EE, Roberts J, Barry PA, Hartigan-O'Connor DJ, Dandekar S. Subclinical cytomegalovirus infection associates with altered host immunity, gut microbiota and vaccine responses. J Virol. 2018 Apr 18. PMID: 29669841.
      View in: PubMed
    5. Eckstrand CD, Sparger EE, Murphy BG. Central and peripheral reservoirs of feline immunodeficiency virus in cats: a review. J Gen Virol. 2017 Aug; 98(8):1985-1996. PMID: 28749325.
      View in: PubMed
    6. Chang WL, Gonzalez DF, Kieu HT, Castillo LD, Messaoudi I, Shen X, Tomaras GD, Shacklett BL, Barry PA, Sparger EE. Changes in Circulating B Cell Subsets Associated with Aging and Acute SIV Infection in Rhesus Macaques. PLoS One. 2017; 12(1):e0170154. PMID: 28095513.
      View in: PubMed
    7. Park JS, Withers SS, Modiano JF, Kent MS, Chen M, Luna JI, Culp WTN, Sparger EE, Rebhun RB, Monjazeb AM, Murphy WJ, Canter RJ. Canine cancer immunotherapy studies: linking mouse and human. J Immunother Cancer. 2016; 4:97. PMID: 28031824.
      View in: PubMed
    8. Deere JD, Chang WL, Castillo LD, Schmidt KA, Kieu HT, Renzette N, Kowalik T, Barthold SW, Shacklett BL, Barry PA, Sparger EE. Utilizing a TLR5-Adjuvanted Cytomegalovirus as a Lentiviral Vaccine in the Nonhuman Primate Model for AIDS. PLoS One. 2016; 11(5):e0155629. PMID: 27182601.
      View in: PubMed
    9. McDonnel SJ, Sparger EE, Murphy BG. Feline immunodeficiency virus latency. Retrovirology. 2013 Jul 06; 10:69. PMID: 23829177; PMCID: PMC3707804.
    10. McDonnel SJ, Sparger EE, Luciw PA, Murphy BG. Pharmacologic reactivation of latent feline immunodeficiency virus ex vivo in peripheral CD4+ T-lymphocytes. Virus Res. 2012 Dec; 170(1-2):174-9. PMID: 23073179; PMCID: PMC3513637.
    11. McDonnel SJ, Sparger EE, Luciw PA, Murphy BG. Transcriptional regulation of latent feline immunodeficiency virus in peripheral CD4+ T-lymphocytes. Viruses. 2012 05; 4(5):878-88. PMID: 22754653; PMCID: PMC3386631.
    12. Murphy B, Vapniarsky N, Hillman C, Castillo D, McDonnel S, Moore P, Luciw PA, Sparger EE. FIV establishes a latent infection in feline peripheral blood CD4+ T lymphocytes in vivo during the asymptomatic phase of infection. Retrovirology. 2012 Feb 07; 9:12. PMID: 22314004; PMCID: PMC3292463.
    13. Sparger EE, Gardner MB, Barry PA. Exploiting the natural history of cytomegalovirus to vaccinate against HIV. Expert Rev Vaccines. 2009 Aug; 8(8):993-7. PMID: 19627183.
      View in: PubMed
    14. Maksaereekul S, Dubie RA, Shen X, Kieu H, Dean GA, Sparger EE. Vaccination with vif-deleted feline immunodeficiency virus provirus, GM-CSF, and TNF-alpha plasmids preserves global CD4 T lymphocyte function after challenge with FIV. Vaccine. 2009 Jun 08; 27(28):3754-65. PMID: 19464559; PMCID: PMC2802579.
    15. Dubie RA, Maksaereekul S, Shacklett BL, Lemongello D, Cole KS, Villinger F, Blozis SA, Luciw PA, Sparger EE. Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251. Virology. 2009 Mar 30; 386(1):109-21. PMID: 19193388; PMCID: PMC3640844.
    16. Sparger EE, Dubie RA, Shacklett BL, Cole KS, Chang WL, Luciw PA. Vaccination of rhesus macaques with a vif-deleted simian immunodeficiency virus proviral DNA vaccine. Virology. 2008 May 10; 374(2):261-72. PMID: 18261756; PMCID: PMC2519864.
    17. Shen X, Leutenegger CM, Stefano Cole K, Pedersen NC, Sparger EE. A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens. J Gen Virol. 2007 Oct; 88(Pt 10):2793-9. PMID: 17872533.
      View in: PubMed
    18. Gupta S, Leutenegger CM, Dean GA, Steckbeck JD, Cole KS, Sparger EE. Vaccination of cats with attenuated feline immunodeficiency virus proviral DNA vaccine expressing gamma interferon. J Virol. 2007 Jan; 81(2):465-73. PMID: 17079309; PMCID: PMC1797444.
    19. Gupta S, Leutenegger C, Dean G, Sparger E. Construction and characterization of feline immunodeficiency virus proviral mutants that coexpress interferon gamma and green fluorescent protein. AIDS Res Hum Retroviruses. 2006 Apr; 22(4):342-9. PMID: 16623638.
      View in: PubMed
    20. Gemeniano MC, Sawai ET, Sparger EE. Feline immunodeficiency virus Orf-A localizes to the nucleus and induces cell cycle arrest. Virology. 2004 Aug 01; 325(2):167-74. PMID: 15246256.
      View in: PubMed
    21. Gemeniano MC, Sawai ET, Leutenegger CM, Sparger EE. Feline immunodeficiency virus ORF-Ais required for virus particle formation and virus infectivity. J Virol. 2003 Aug; 77(16):8819-30. PMID: 12885901; PMCID: PMC167212.
    22. Sparger EE, Louie H, Ziomeck AM, Luciw PA. Infection of cats by injection with DNA of a feline immunodeficiency virus molecular clone. Virology. 1997 Nov 10; 238(1):157-60. PMID: 9375019.
      View in: PubMed