Luke Anthony Wittenburg

Title(s)Associate Professor, VM: Surgery/Radiology Science
SchoolSchool of Veterinary Medicine
Address218 CCAH
CA 95616
Phone530-754-5711
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cardiac myosin inhibitor, CK-586, minimally reduces systolic function and ameliorates obstruction in feline hypertrophic cardiomyopathy. Sci Rep. 2024 05 27; 14(1):12038. Rivas VN, Crofton AE, Jauregui CE, Wouters JR, Yang BS, Wittenburg LA, Kaplan JL, Hwee DT, Murphy AN, Morgan BP, Malik FI, Harris SP, Stern JA. PMID: 38802475; PMCID: PMC11130313.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    2. Correction: Cook et al. An Optimized Bioassay for Screening Combined Anticoronaviral Compounds for Efficacy against Feline Infectious Peritonitis Virus with Pharmacokinetic Analyses of GS-441524, Remdesivir, and Molnupiravir in Cats. Viruses 2022, 14, 2429. Viruses. 2024 Mar 04; 16(3). Cook S, Wittenburg L, Yan VC, Theil JH, Castillo D, Reagan KL, Williams S, Pham CD, Li C, Muller FL, Murphy BG. PMID: 38543851; PMCID: PMC10975337.
      View in: PubMed   Mentions:    Fields:    
    3. Pharmacokinetics of a Single Transdermal Dose of Mirtazapine in Rhesus Macaques (Macaca mulatta). Comp Med. 2023 Dec 01; 73(6):432-438. Bissinger DW, Wittenburg LA, Garzel LM, Stockinger DE, Timmel GB. PMID: 38217071; PMCID: PMC10752366.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Effects of pulsatile intravenous follicle-stimulating hormone treatment on ovarian function in women with obesity. Fertil Steril. 2023 10; 120(4):890-898. Luu TH, Kuhn K, Bradford AP, Wempe MF, Wittenburg L, Johnson RL, Carlson NE, Kumar TR, Polotsky AJ. PMID: 37276947; PMCID: PMC10526695.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue-specific drug binding, transport, and metabolism. Pharmacol Res Perspect. 2023 02; 11(1):e01052. Witta S, Collins KP, Ramirez DA, Mannheimer JD, Wittenburg LA, Gustafson DL. PMID: 36631976; PMCID: PMC9834611.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    6. Microglia-Derived Olfactomedin-like 3 Is a Potent Angiogenic Factor in Primary Mouse Brain Endothelial Cells: A Novel Target for Glioblastoma. Int J Mol Sci. 2022 Nov 23; 23(23). Joseph LM, Toedebusch RG, Debebe E, Bastian AH, Lucchesi CA, Syed-Quadri S, Wittenburg LA, Chen X, Meyers FJ, Toedebusch CM. PMID: 36498941; PMCID: PMC9741462.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. An Optimized Bioassay for Screening Combined Anticoronaviral Compounds for Efficacy against Feline Infectious Peritonitis Virus with Pharmacokinetic Analyses of GS-441524, Remdesivir, and Molnupiravir in Cats. Viruses. 2022 11 01; 14(11). Cook S, Wittenburg L, Yan VC, Theil JH, Castillo D, Reagan KL, Williams S, Pham CD, Li C, Muller FL, Murphy BG. PMID: 36366527; PMCID: PMC9697187.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    8. Population pharmacokinetics identifies rapid gastrointestinal absorption and plasma clearance of oral chlorambucil administered to cats with indolent lymphoproliferative malignancies. Am J Vet Res. 2022 Sep 29; 83(11):1-9. Al-Nadaf S, Wittenburg LA, Skorupski KA, Burton JH. PMID: 36155936; PMCID: PMC10117151.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Fractionated oral dosing and its effect on cyclophosphamide pharmacokinetics in dogs with high-grade multicentric lymphoma. Vet Comp Oncol. 2023 Mar; 21(1):20-27. Veluvolu S, Willcox JL, Skorupski KA, Al-Nadaf S, Rebhun R, Wittenburg L. PMID: 36057542; PMCID: PMC9928601.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    10. Effect of standard-dose and high-dose pimobendan on select indices of renal and cardiac function in dogs with American College of Veterinary Internal Medicine stage B2 myxomatous mitral valve disease. J Vet Intern Med. 2022 Nov; 36(6):1892-1899. Kaplan JL, Visser LC, Gunther-Harrington CT, Ontiveros ES, Wittenburg LA, Palm CA, Stern JA. PMID: 36098206; PMCID: PMC9708424.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    11. Pharmacokinetic study comparing doxorubicin concentrations after chemoembolization or intravenous administration in dogs with naturally occurring nonresectable hepatic carcinoma. J Vet Intern Med. 2022 Sep; 36(5):1792-1799. Samuel N, Weisse C, Berent AC, Rogatko CP, Wittenburg L, Lamb K. PMID: 35971921; PMCID: PMC9511073.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    12. Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response. J Immunother Cancer. 2022 06; 10(6). Rebhun RB, York D, Cruz SM, Judge SJ, Razmara AM, Farley LE, Brady RV, Johnson EG, Burton JH, Willcox J, Wittenburg LA, Woolard K, Dunai C, Stewart SL, Sparger EE, Withers SS, Gingrich AA, Skorupski KA, Al-Nadaf S, LeJeune AT, Culp WT, Murphy WJ, Kent MS, Canter RJ. PMID: 35680383; PMCID: PMC9174838.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    13. Prevalence and Clinicopathologic Features of Canine Metastatic Melanoma Involving the Central Nervous System: A Retrospective Analysis and Comparative Review. Front Oncol. 2022; 12:868004. Razmara AM, Wittenburg LA, Al-Nadaf S, Toedebusch RG, Meyers FJ, Toedebusch CM. PMID: 35692802; PMCID: PMC9186031.
      View in: PubMed   Mentions: 1  
    14. Pharmacokinetics of isavuconazole in healthy cats after oral and intravenous administration. J Vet Intern Med. 2022 Jul; 36(4):1422-1429. Woerde DJ, Wittenburg LA, Dear JD. PMID: 35616184; PMCID: PMC9308414.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    15. Serum concentrations of gabapentin in cats with chronic kidney disease. J Feline Med Surg. 2022 12; 24(12):1260-1266. Quimby JM, Lorbach SK, Saffire A, Kennedy A, Wittenburg LA, Aarnes TK, Creighton KJ, Jones SE, Paschall RE, King EM, Bruner CE, Wallinger JN, van Haaften KA. PMID: 35195476; PMCID: PMC9395545.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    16. Microglia-Derived Olfactomedin-like 3 Promotes Pro-Tumorigenic Microglial Function and Malignant Features of Glioma Cells. Int J Mol Sci. 2021 Dec 02; 22(23). Toedebusch RG, Lucchesi CA, Debebe ET, Wittenburg LA, Chen X, Toedebusch CM. PMID: 34884869; PMCID: PMC8657851.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. The interaction between RUNX2 and core binding factor beta as a potential therapeutic target in canine osteosarcoma. Vet Comp Oncol. 2020 Mar; 18(1):52-63. Alegre F, Ormonde AR, Godinez DR, Illendula A, Bushweller JH, Wittenburg LA. PMID: 31381810; PMCID: PMC7233265.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    18. Pilot study comparing serum chemotherapy levels after intra-arterial and intravenous administration in dogs with naturally occurring urinary tract tumors. Can J Vet Res. 2019 Jul; 83(3):187-196. Kirsch M, Weisse C, Berent A, Clifford C, Leibman N, Wittenburg L, Solomon SB, Lamb K. PMID: 31308591; PMCID: PMC6587882.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    19. Doxorubicin area under the curve is an important predictor of neutropenia in dogs with naturally occurring cancers. Vet Comp Oncol. 2019 Jun; 17(2):147-154. Wittenburg LA, Weishaar K, Ramirez D, Gustafson DL. PMID: 30638304; PMCID: PMC6478528.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    20. A genetically engineered microRNA-34a prodrug demonstrates anti-tumor activity in a canine model of osteosarcoma. PLoS One. 2018; 13(12):e0209941. Alegre F, Ormonde AR, Snider KM, Woolard K, Yu AM, Wittenburg LA. PMID: 30596759; PMCID: PMC6312226.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    21. Simultaneous absolute quantitation of ATP-binding cassette transporters in normal dog tissues by signature peptide analysis using a LC/MS/MS method. Res Vet Sci. 2019 Feb; 122:93-101. Wittenburg LA, Ramirez D, Conger H, Gustafson DL. PMID: 30500618; PMCID: PMC6522139.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    22. In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease. J Vet Intern Med. 2018 Nov; 32(6):1951-1957. Fitzpatrick RL, Quimby JM, Benson KK, Ramirez D, Sieberg LG, Wittenburg LA, Gustafson DL. PMID: 30307637; PMCID: PMC6272035.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    23. In vitro and in vivo activity of liposome-encapsulated curcumin for naturally occurring canine cancers. Vet Comp Oncol. 2018 Dec; 16(4):571-579. Withers SS, York D, Johnson E, Al-Nadaf S, Skorupski KA, Rodriguez CO, Burton JH, Guerrero T, Sein K, Wittenburg L, Rebhun RB. PMID: 30088848; PMCID: PMC6234083.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    24. Pharmacokinetics of cannabidiol administered by 3 delivery methods at 2 different dosages to healthy dogs. Can J Vet Res. 2018 Jul; 82(3):178-183. Bartner LR, McGrath S, Rao S, Hyatt LK, Wittenburg LA. PMID: 30026641; PMCID: PMC6038832.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    25. Preliminary pharmacokinetics of intravenous and subcutaneous dolasetron and pharmacodynamics of subcutaneous dolasetron in healthy cats. J Feline Med Surg. 2018 08; 20(8):721-727. Herndon AK, Quimby JM, Sieberg LG, Davis L, Caress AL, Ligas S, Hansen RJ, Wittenburg LA, Gustafson DL. PMID: 28905667; PMCID: PMC11104135.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    26. Assessment of absorption of transdermal ondansetron in normal research cats. J Feline Med Surg. 2017 Dec; 19(12):1245-1248. Zajic LB, Herndon AK, Sieberg LG, Caress AL, Morgan PK, Hansen RJ, Wittenburg LA, Gustafson DL, Quimby JM. PMID: 28112563; PMCID: PMC11104180.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    27. Anti-inflammatory drugs decrease infection of brain endothelial cells with EHV-1 in vitro. Equine Vet J. 2017 Sep; 49(5):629-636. Goehring LS, Brandes K, Ashton LV, Wittenburg LA, Olea-Popelka FJ, Lunn DP, Soboll Hussey G. PMID: 27864898.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    28. Docetaxel Accumulates in Lymphatic Circulation Following Subcutaneous Delivery Compared to Intravenous Delivery in Rats. Anticancer Res. 2016 10; 36(10):5071-5078. Worley DR, Hansen RJ, Wittenburg LA, Chubb LS, Gustafson DL. PMID: 27798866; PMCID: PMC5501171.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    29. Drug exposure and clinical effect of transdermal mirtazapine in healthy young cats: a pilot study. J Feline Med Surg. 2017 Oct; 19(10):998-1006. Benson KK, Zajic LB, Morgan PK, Brown SR, Hansen RJ, Lunghofer PJ, Wittenburg LA, Gustafson DL, Quimby JM. PMID: 27613493; PMCID: PMC5647142.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCTClinical Trials
    30. Plasma, subcutaneous tissue and bone concentrations of ceftiofur sodium after regional limb perfusion in horses. Equine Vet J. 2017 May; 49(3):341-344. Cox KS, Nelson BB, Wittenburg L, Gold JR. PMID: 27458113.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCTClinical Trials
    31. The Effects of Mepivacaine Hydrochloride on Antimicrobial Activity and Mechanical Nociceptive Threshold During Amikacin Sulfate Regional Limb Perfusion in the Horse. Vet Surg. 2016 Aug; 45(6):798-803. Colbath AC, Wittenburg LA, Gold JR, McIlwraith CW, Moorman VJ. PMID: 27416788.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCTClinical Trials
    32. Limited sampling pharmacokinetics of subcutaneous ondansetron in healthy geriatric cats, cats with chronic kidney disease, and cats with liver disease. J Vet Pharmacol Ther. 2016 Aug; 39(4):350-5. Fitzpatrick RL, Wittenburg LA, Hansen RJ, Gustafson DL, Quimby JM. PMID: 26667224; PMCID: PMC6994184.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    33. Pharmacokinetics and bioavailability of orbifloxacin oral suspension in New Zealand White rabbits (Oryctolagus cuniculus). Am J Vet Res. 2015 Nov; 76(11):946-51. Watson MK, Wittenburg LA, Bui CT, Jarosz KA, Gustafson DL, Johnston MS. PMID: 26512539.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    34. Pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban after oral and intravenous administration to cats. Am J Vet Res. 2015 Aug; 76(8):732-8. Myers JA, Wittenburg LA, Olver CS, Martinez CM, Bright JM. PMID: 26207972.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    35. Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma. Autophagy. 2014 Aug; 10(8):1415-25. Barnard RA, Wittenburg LA, Amaravadi RK, Gustafson DL, Thorburn A, Thamm DH. PMID: 24991836; PMCID: PMC4203518.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCTClinical Trials
    36. Endometrial tissue and blood plasma concentration of ceftiofur and metabolites following intramuscular administration of ceftiofur crystalline free acid to mares. Equine Vet J. 2014 Sep; 46(5):606-10. Scofield D, Black J, Wittenburg L, Gustafson D, Ferris R, Hatzel J, Traub-Dargatz J, McCue P. PMID: 24111546.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    37. A pilot phase II study of the efficacy and biosafety of doxorubicin chemotherapy in tumor-bearing equidae. J Vet Intern Med. 2013 Nov-Dec; 27(6):1581-8. Théon AP, Pusterla N, Magdesian KG, Wittenburg L, Marmulak T, Wilson WD. PMID: 24107145.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsPHPublic HealthCTClinical Trials
    38. Effect of topical naltrexone 0.3% on corneal sensitivity and tear parameters in normal brachycephalic dogs. Vet Ophthalmol. 2014 Sep; 17(5):328-33. Arnold TS, Wittenburg LA, Powell CC. PMID: 23802568.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    39. Development of a limited-sampling model for prediction of doxorubicin exposure in dogs. Vet Comp Oncol. 2014 Jun; 12(2):114-9. Wittenburg LA, Thamm DH, Gustafson DL. PMID: 22747489; PMCID: PMC3897556.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    40. A systems biology approach to identify molecular pathways altered by HDAC inhibition in osteosarcoma. J Cell Biochem. 2012 Mar; 113(3):773-83. Wittenburg LA, Ptitsyn AA, Thamm DH. PMID: 21976144; PMCID: PMC4667946.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    41. Optimizing preclinical study design in oncology research. Chem Biol Interact. 2011 Apr 25; 190(2-3):73-8. Wittenburg LA, Gustafson DL. PMID: 21296059.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    42. Phase I pharmacokinetic and pharmacodynamic evaluation of combined valproic acid/doxorubicin treatment in dogs with spontaneous cancer. Clin Cancer Res. 2010 Oct 01; 16(19):4832-42. Wittenburg LA, Gustafson DL, Thamm DH. PMID: 20705615; PMCID: PMC2948605.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCTClinical Trials
    43. The histone deacetylase inhibitor valproic acid sensitizes human and canine osteosarcoma to doxorubicin. Cancer Chemother Pharmacol. 2011 Jan; 67(1):83-92. Wittenburg LA, Bisson L, Rose BJ, Korch C, Thamm DH. PMID: 20306194; PMCID: PMC2916050.
      View in: PubMed   Mentions: 30     Fields:    
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