Loading...

Aiming Yu

Title(s)Professor, Biochemistry and Molecular Medicine
SchoolUniversity of California, Davis
Phone916-734-1566
vCardDownload vCard

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Alegre F, Ormonde AR, Snider KM, Woolard K, Yu AM, Wittenburg LA. A genetically engineered microRNA-34a prodrug demonstrates anti-tumor activity in a canine model of osteosarcoma. PLoS One. 2018; 13(12):e0209941. PMID: 30596759.
      View in: PubMed
    2. Yu AM, Jian C, Yu AH, Tu MJ. RNA therapy: Are we using the right molecules? Pharmacol Ther. 2019 Apr; 196:91-104. PMID: 30521885.
      View in: PubMed
    3. Tu MJ, Ho PY, Zhang QY, Jian C, Qiu JX, Kim EJ, Bold RJ, Gonzalez FJ, Bi H, Yu AM. Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models. Cancer Lett. 2019 02 01; 442:82-90. PMID: 30389433.
      View in: PubMed
    4. Guan L, Chen Y, Wang Y, Zhang H, Fan S, Gao Y, Jiao T, Fu K, Sun J, Yu A, Huang M, Bi H. Effects of carnitine palmitoyltransferases on cancer cellular senescence. J Cell Physiol. 2019 Feb; 234(2):1707-1719. PMID: 30070697.
      View in: PubMed
    5. Zhang QY, Ho PY, Tu MJ, Jilek JL, Chen QX, Zeng S, Yu AM. Lipidation of polyethylenimine-based polyplex increases serum stability of bioengineered RNAi agents and offers more consistent tumoral gene knockdown in vivo. Int J Pharm. 2018 Aug 25; 547(1-2):537-544. PMID: 29894758.
      View in: PubMed
    6. Ho PY, Duan Z, Batra N, Jilek JL, Tu MJ, Qiu JX, Hu Z, Wun T, Lara PN, DeVere White RW, Chen HW, Yu AM. Bioengineered Noncoding RNAs Selectively Change Cellular miRNome Profiles for Cancer Therapy. J Pharmacol Exp Ther. 2018 06; 365(3):494-506. PMID: 29602831.
      View in: PubMed
    7. Wang Y, Chen Y, Guan L, Zhang H, Huang Y, Johnson CH, Wu Z, Gonzalez FJ, Yu A, Huang P, Wang Y, Yang S, Chen P, Fan X, Huang M, Bi H. Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming. Cell Death Differ. 2018 03; 25(4):735-748. PMID: 29317762.
      View in: PubMed
    8. Li PC, Tu MJ, Ho PY, Jilek JL, Duan Z, Zhang QY, Yu AX, Yu AM. Bioengineered NRF2-siRNA Is Effective to Interfere with NRF2 Pathways and Improve Chemosensitivity of Human Cancer Cells. Drug Metab Dispos. 2018 01; 46(1):2-10. PMID: 29061583.
      View in: PubMed
    9. Yang QJ, Kluger M, Gorynski K, Pawliszyn J, Bojko B, Yu AM, Noh K, Selzner M, Jerath A, McCluskey S, Pang KS, Wasowicz M. Comparing early liver graft function from heart beating and living-donors: A pilot study aiming to identify new biomarkers of liver injury. Biopharm Drug Dispos. 2017 Jul; 38(5):326-339. PMID: 28102538.
      View in: PubMed
    10. Chen Y, Wang Y, Huang Y, Zeng H, Hu B, Guan L, Zhang H, Yu AM, Johnson CH, Gonzalez FJ, Huang M, Bi H. PPARa regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C. Carcinogenesis. 2017 04 01; 38(4):474-483. PMID: 28334197.
      View in: PubMed
    11. Jilek JL, Tian Y, Yu AM. Effects of MicroRNA-34a on the Pharmacokinetics of Cytochrome P450 Probe Drugs in Mice. Drug Metab Dispos. 2017 05; 45(5):512-522. PMID: 28254952.
      View in: PubMed
    12. Francois LN, Gorczyca L, Du J, Bircsak KM, Yen E, Wen X, Tu MJ, Yu AM, Illsley NP, Zamudio S, Aleksunes LM. Down-regulation of the placental BCRP/ABCG2 transporter in response to hypoxia signaling. Placenta. 2017 03; 51:57-63. PMID: 28292469.
      View in: PubMed
    13. Zhang K, Bian J, Deng Y, Smith A, Nunez RE, Li MB, Pal U, Yu AM, Qiu W, Ealick SE, Li C. Lyme disease spirochaete Borrelia burgdorferi does not require thiamin. Nat Microbiol. 2016 Nov 21; 2:16213. PMID: 27869793.
      View in: PubMed
    14. Rodrigues AC, Neri EA, Veríssimo-Filho S, Rebouças NA, Hirata RD, Yu AM. Atorvastatin attenuation of ABCB1 expression is mediated by microRNA miR-491-3p in Caco-2 cells. Eur J Pharm Sci. 2016 Oct 10; 93:431-6. PMID: 27575876.
      View in: PubMed
    15. Tu MJ, Pan YZ, Qiu JX, Kim EJ, Yu AM. MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis. Oncotarget. 2016 Jul 19; 7(29):45547-45561. PMID: 27322206.
      View in: PubMed
    16. Duan Z, Yu AM. Bioengineered non-coding RNA agent (BERA) in action. Bioengineered. 2016 Nov; 7(6):411-417. PMID: 27415469.
      View in: PubMed
    17. Zhao Y, Tu MJ, Wang WP, Qiu JX, Yu AX, Yu AM. Genetically engineered pre-microRNA-34a prodrug suppresses orthotopic osteosarcoma xenograft tumor growth via the induction of apoptosis and cell cycle arrest. Sci Rep. 2016 05 24; 6:26611. PMID: 27216562.
      View in: PubMed
    18. Yu T, Wang Y, Zhang H, Johnson CH, Jiang Y, Li X, Wu Z, Liu T, Krausz KW, Yu A, Gonzalez FJ, Huang M, Bi H. Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells. Anal Bioanal Chem. 2016 Jun; 408(16):4267-73. PMID: 27074779.
      View in: PubMed
    19. Jiang XL, Shen HW, Yu AM. Modification of 5-methoxy-N,N-dimethyltryptamine-induced hyperactivity by monoamine oxidase A inhibitor harmaline in mice and the underlying serotonergic mechanisms. Pharmacol Rep. 2016 Jun; 68(3):608-15. PMID: 26977821.
      View in: PubMed
    20. Ho PY, Yu AM. Bioengineering of noncoding RNAs for research agents and therapeutics. Wiley Interdiscip Rev RNA. 2016 Mar-Apr; 7(2):186-97. PMID: 26763749.
      View in: PubMed
    21. Yu AM, Tian Y, Tu MJ, Ho PY, Jilek JL. MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy. Drug Metab Dispos. 2016 Mar; 44(3):308-19. PMID: 26566807.
      View in: PubMed
    22. Zhao Y, Tu MJ, Yu YF, Wang WP, Chen QX, Qiu JX, Yu AX, Yu AM. Combination therapy with bioengineered miR-34a prodrug and doxorubicin synergistically suppresses osteosarcoma growth. Biochem Pharmacol. 2015 Dec 15; 98(4):602-13. PMID: 26518752.
      View in: PubMed
    23. Wang WP, Ho PY, Chen QX, Addepalli B, Limbach PA, Li MM, Wu WJ, Jilek JL, Qiu JX, Zhang HJ, Li T, Wun T, White RD, Lam KS, Yu AM. Bioengineering Novel Chimeric microRNA-34a for Prodrug Cancer Therapy: High-Yield Expression and Purification, and Structural and Functional Characterization. J Pharmacol Exp Ther. 2015 Aug; 354(2):131-41. PMID: 26022002.
      View in: PubMed
    24. Li MM, Addepalli B, Tu MJ, Chen QX, Wang WP, Limbach PA, LaSalle JM, Zeng S, Huang M, Yu AM. Chimeric MicroRNA-1291 Biosynthesized Efficiently in Escherichia coli Is Effective to Reduce Target Gene Expression in Human Carcinoma Cells and Improve Chemosensitivity. Drug Metab Dispos. 2015 Jul; 43(7):1129-36. PMID: 25934574.
      View in: PubMed
    25. Chen QX, Wang WP, Zeng S, Urayama S, Yu AM. A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications. Nucleic Acids Res. 2015 Apr 20; 43(7):3857-69. PMID: 25800741.
      View in: PubMed
    26. Jiang XL, Shen HW, Yu AM. Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors. Neuropharmacology. 2015 Feb; 89:342-51. PMID: 25446678.
      View in: PubMed
    27. Yu T, Wang YT, Chen P, Li YH, Chen YX, Zeng H, Yu AM, Huang M, Bi HC. Effects of nicotinamide N-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress. Cell Physiol Biochem. 2015; 35(2):710-21. PMID: 25592232.
      View in: PubMed
    28. Tian Y, Bian Y, Jiang Y, Qian S, Yu A, Zeng S. Interplay of Breast Cancer Resistance Protein (BCRP) and Metabolizing Enzymes. Curr Drug Metab. 2015; 16(10):877-93. PMID: 26652256.
      View in: PubMed
    29. Li MM, Wang WP, Wu WJ, Huang M, Yu AM. Rapid production of novel pre-microRNA agent hsa-mir-27b in Escherichia coli using recombinant RNA technology for functional studies in mammalian cells. Drug Metab Dispos. 2014 Nov; 42(11):1791-5. PMID: 25161167.
      View in: PubMed
    30. Bi HC, Pan YZ, Qiu JX, Krausz KW, Li F, Johnson CH, Jiang CT, Gonzalez FJ, Yu AM. N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. Carcinogenesis. 2014 Oct; 35(10):2264-72. PMID: 25115443.
      View in: PubMed
    31. Ju Y, Xu T, Zhang H, Yu A. FOXO1-dependent DNA damage repair is regulated by JNK in lung cancer cells. Int J Oncol. 2014 Apr; 44(4):1284-92. PMID: 24452601.
      View in: PubMed
    32. Choi YH, Yu AM. ABC transporters in multidrug resistance and pharmacokinetics, and strategies for drug development. Curr Pharm Des. 2014; 20(5):793-807. PMID: 23688078.
      View in: PubMed
    33. Koh KH, Pan X, Shen HW, Arnold SL, Yu AM, Gonzalez FJ, Isoherranen N, Jeong H. Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice. J Biol Chem. 2014 Feb 07; 289(6):3105-13. PMID: 24318876.
      View in: PubMed
    34. Ingelman-Sundberg M, Zhong XB, Hankinson O, Beedanagari S, Yu AM, Peng L, Osawa Y. Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport. Drug Metab Dispos. 2013 Oct; 41(10):1725-31. PMID: 23918665.
      View in: PubMed
    35. Pan YZ, Zhou A, Hu Z, Yu AM. Small nucleolar RNA-derived microRNA hsa-miR-1291 modulates cellular drug disposition through direct targeting of ABC transporter ABCC1. Drug Metab Dispos. 2013 Oct; 41(10):1744-51. PMID: 23686318.
      View in: PubMed
    36. Cheng J, Zhen Y, Miksys S, Beyoglu D, Krausz KW, Tyndale RF, Yu A, Idle JR, Gonzalez FJ. Potential role of CYP2D6 in the central nervous system. Xenobiotica. 2013 Nov; 43(11):973-84. PMID: 23614566.
      View in: PubMed
    37. Sze CW, Smith A, Choi YH, Yang X, Pal U, Yu A, Li C. Study of the response regulator Rrp1 reveals its regulatory role in chitobiose utilization and virulence of Borrelia burgdorferi. Infect Immun. 2013 May; 81(5):1775-87. PMID: 23478317.
      View in: PubMed
    38. Jiang XL, Shen HW, Mager DE, Yu AM. Pharmacokinetic interactions between monoamine oxidase A inhibitor harmaline and 5-methoxy-N,N-dimethyltryptamine, and the impact of CYP2D6 status. Drug Metab Dispos. 2013 May; 41(5):975-86. PMID: 23393220.
      View in: PubMed
    39. Chen QX, Hu HH, Zhou Q, Yu AM, Zeng S. An overview of ABC and SLC drug transporter gene regulation. Curr Drug Metab. 2013 Feb; 14(2):253-64. PMID: 23116109.
      View in: PubMed
    40. Bruno AE, Li L, Kalabus JL, Pan Y, Yu A, Hu Z. miRdSNP: a database of disease-associated SNPs and microRNA target sites on 3'UTRs of human genes. BMC Genomics. 2012 Jan 25; 13:44. PMID: 22276777.
      View in: PubMed
    41. Shen HW, Jiang XL, Gonzalez FJ, Yu AM. Humanized transgenic mouse models for drug metabolism and pharmacokinetic research. Curr Drug Metab. 2011 Dec; 12(10):997-1006. PMID: 22023319.
      View in: PubMed
    42. Rodrigues AC, Li X, Radecki L, Pan YZ, Winter JC, Huang M, Yu AM. MicroRNA expression is differentially altered by xenobiotic drugs in different human cell lines. Biopharm Drug Dispos. 2011 Sep; 32(6):355-67. PMID: 21796641.
      View in: PubMed
    43. Bian J, Shen H, Tu Y, Yu A, Li C. The riboswitch regulates a thiamine pyrophosphate ABC transporter of the oral spirochete Treponema denticola. J Bacteriol. 2011 Aug; 193(15):3912-22. PMID: 21622748.
      View in: PubMed
    44. Winter JC, Amorosi DJ, Rice KC, Cheng K, Yu AM. Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice. Pharmacol Biochem Behav. 2011 Sep; 99(3):311-5. PMID: 21624387.
      View in: PubMed
    45. Shen HW, Jiang XL, Yu AM. Nonlinear pharmacokinetics of 5-methoxy-N,N-dimethyltryptamine in mice. Drug Metab Dispos. 2011 Jul; 39(7):1227-34. PMID: 21464174.
      View in: PubMed
    46. Li X, Pan YZ, Seigel GM, Hu ZH, Huang M, Yu AM. Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328, -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cells. Biochem Pharmacol. 2011 Mar 15; 81(6):783-92. PMID: 21219875.
      View in: PubMed
    47. Koh KH, Xie H, Yu AM, Jeong H. Altered cytochrome P450 expression in mice during pregnancy. Drug Metab Dispos. 2011 Feb; 39(2):165-9. PMID: 20971892.
      View in: PubMed
    48. Shen HW, Jiang XL, Winter JC, Yu AM. Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions. Curr Drug Metab. 2010 Oct; 11(8):659-66. PMID: 20942780.
      View in: PubMed
    49. Jiang XL, Gonzalez FJ, Yu AM. Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models. Drug Metab Rev. 2011 Feb; 43(1):27-40. PMID: 20854191.
      View in: PubMed
    50. Shen HW, Wu C, Jiang XL, Yu AM. Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5-methoxy-N,N-dimethyltryptamine metabolism and pharmacokinetics. Biochem Pharmacol. 2010 Jul 01; 80(1):122-8. PMID: 20206139.
      View in: PubMed
    51. Shen HW, Yu AM. Conference report: new analytical technologies for biological discovery. Bioanalysis. 2010 Feb; 2(2):181-4. PMID: 21083300.
      View in: PubMed
    52. Shen HW, Yu AM. Difference in desipramine metabolic profile between wild-type and CYP2D6-humanized mice. Drug Metab Lett. 2009 Dec; 3(4):234-41. PMID: 19995332.
      View in: PubMed
    53. Yu AM. Role of microRNAs in the regulation of drug metabolism and disposition. Expert Opin Drug Metab Toxicol. 2009 Dec; 5(12):1513-28. PMID: 19785514.
      View in: PubMed
    54. Pan YZ, Gao W, Yu AM. MicroRNAs regulate CYP3A4 expression via direct and indirect targeting. Drug Metab Dispos. 2009 Oct; 37(10):2112-7. PMID: 19581388.
      View in: PubMed
    55. Wu C, Jiang XL, Shen HW, Yu AM. Effects of CYP2D6 status on harmaline metabolism, pharmacokinetics and pharmacodynamics, and a pharmacogenetics-based pharmacokinetic model. Biochem Pharmacol. 2009 Sep 15; 78(6):617-24. PMID: 19445902.
      View in: PubMed
    56. Pan YZ, Morris ME, Yu AM. MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells. Mol Pharmacol. 2009 Jun; 75(6):1374-9. PMID: 19270061.
      View in: PubMed
    57. Jiang XL, Shen HW, Yu AM. Pinoline may be used as a probe for CYP2D6 activity. Drug Metab Dispos. 2009 Mar; 37(3):443-6. PMID: 19095720.
      View in: PubMed
    58. Zhang WY, Tu YB, Haining RL, Yu AM. Expression and functional analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 isozymes. Drug Metab Dispos. 2009 Jan; 37(1):1-4. PMID: 18838503.
      View in: PubMed
    59. Yu AM, Qu J, Felmlee MA, Cao J, Jiang XL. Quantitation of human cytochrome P450 2D6 protein with immunoblot and mass spectrometry analysis. Drug Metab Dispos. 2009 Jan; 37(1):170-7. PMID: 18832475.
      View in: PubMed
    60. Yu AM. Indolealkylamines: biotransformations and potential drug-drug interactions. AAPS J. 2008 Jun; 10(2):242-53. PMID: 18454322.
      View in: PubMed
    61. Felmlee MA, Lon HK, Gonzalez FJ, Yu AM. Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice. Drug Metab Dispos. 2008 Feb; 36(2):435-41. PMID: 18048490.
      View in: PubMed
    62. Yu AM. Small interfering RNA in drug metabolism and transport. Curr Drug Metab. 2007 Oct; 8(7):700-8. PMID: 17979658.
      View in: PubMed
    63. Yu AM, Haining RL. Expression, purification, and characterization of mouse CYP2d22. Drug Metab Dispos. 2006 Jul; 34(7):1167-74. PMID: 16595712.
      View in: PubMed
    64. Gonzalez FJ, Yu AM. Cytochrome P450 and xenobiotic receptor humanized mice. Annu Rev Pharmacol Toxicol. 2006; 46:41-64. PMID: 16402898.
      View in: PubMed
    65. Cheung C, Yu AM, Chen CS, Krausz KW, Byrd LG, Feigenbaum L, Edwards RJ, Waxman DJ, Gonzalez FJ. Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. J Pharmacol Exp Ther. 2006 Mar; 316(3):1328-34. PMID: 16291874.
      View in: PubMed
    66. Inoue Y, Yu AM, Yim SH, Ma X, Krausz KW, Inoue J, Xiang CC, Brownstein MJ, Eggertsen G, Björkhem I, Gonzalez FJ. Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha. J Lipid Res. 2006 Jan; 47(1):215-27. PMID: 16264197.
      View in: PubMed
    67. Yu AM, Fukamachi K, Krausz KW, Cheung C, Gonzalez FJ. Potential role for human cytochrome P450 3A4 in estradiol homeostasis. Endocrinology. 2005 Jul; 146(7):2911-9. PMID: 15817670.
      View in: PubMed
    68. Cheung C, Yu AM, Ward JM, Krausz KW, Akiyama TE, Feigenbaum L, Gonzalez FJ. The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity. Drug Metab Dispos. 2005 Mar; 33(3):449-57. PMID: 15576447.
      View in: PubMed
    69. Yu AM, Idle JR, Gonzalez FJ. Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates. Drug Metab Rev. 2004 May; 36(2):243-77. PMID: 15237854.
      View in: PubMed
    70. Inoue Y, Yu AM, Inoue J, Gonzalez FJ. Hepatocyte nuclear factor 4alpha is a central regulator of bile acid conjugation. J Biol Chem. 2004 Jan 23; 279(4):2480-9. PMID: 14583614.
      View in: PubMed
    71. Yu AM, Idle JR, Herraiz T, Küpfer A, Gonzalez FJ. Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase. Pharmacogenetics. 2003 Jun; 13(6):307-19. PMID: 12777961.
      View in: PubMed
    72. Granvil CP, Yu AM, Elizondo G, Akiyama TE, Cheung C, Feigenbaum L, Krausz KW, Gonzalez FJ. Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam. Drug Metab Dispos. 2003 May; 31(5):548-58. PMID: 12695342.
      View in: PubMed
    73. Yu AM, Idle JR, Krausz KW, Küpfer A, Gonzalez FJ. Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine. J Pharmacol Exp Ther. 2003 Apr; 305(1):315-22. PMID: 12649384.
      View in: PubMed
    74. Kimura S, Kawabe M, Yu A, Morishima H, Fernandez-Salguero P, Hammons GJ, Ward JM, Kadlubar FF, Gonzalez FJ. Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2. Carcinogenesis. 2003 Mar; 24(3):583-7. PMID: 12663521.
      View in: PubMed
    75. Yu AM, Idle JR, Byrd LG, Krausz KW, Küpfer A, Gonzalez FJ. Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6. Pharmacogenetics. 2003 Mar; 13(3):173-81. PMID: 12618595.
      View in: PubMed
    76. Yu AM, Granvil CP, Haining RL, Krausz KW, Corchero J, Küpfer A, Idle JR, Gonzalez FJ. The relative contribution of monoamine oxidase and cytochrome p450 isozymes to the metabolic deamination of the trace amine tryptamine. J Pharmacol Exp Ther. 2003 Feb; 304(2):539-46. PMID: 12538805.
      View in: PubMed
    77. Yu A, Kneller BM, Rettie AE, Haining RL. Expression, purification, biochemical characterization, and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 allelic isoforms. J Pharmacol Exp Ther. 2002 Dec; 303(3):1291-300. PMID: 12438554.
      View in: PubMed
    78. Ramamoorthy Y, Yu AM, Suh N, Haining RL, Tyndale RF, Sellers EM. Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro. Biochem Pharmacol. 2002 Jun 15; 63(12):2111-9. PMID: 12110370.
      View in: PubMed
    79. Yu A, Dong H, Lang D, Haining RL. Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6. Drug Metab Dispos. 2001 Nov; 29(11):1362-5. PMID: 11602510.
      View in: PubMed
    80. Yu A, Haining RL. Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? Drug Metab Dispos. 2001 Nov; 29(11):1514-20. PMID: 11602530.
      View in: PubMed
    81. Yu A, Haining RL. Purification, biochemical characterization and comparative enzyme kinetics of recombinant human CYP2D6 1 and CYP2D6 2 variants. Adv Exp Med Biol. 2001; 500:327-30. PMID: 11764961.
      View in: PubMed