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A predictive model combining clinical characteristics and nutritional risk factors for overall survival after umbilical cord blood transplantation. Stem Cell Res Ther. 2023 Oct 23; 14(1):304.
Tu M, Huang A, Ning L, Tang B, Zhang C, Sun G, Wan X, Song K, Yao W, Qiang P, Wu Y, Zhu X. PMID: 37872622; PMCID: PMC10594692.
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PubMed Mentions: Fields:
Translation:
Humans
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Use of recombinant microRNAs as antimetabolites to inhibit human non-small cell lung cancer. Acta Pharm Sin B. 2023 Oct; 13(10):4273-4290.
Chen Y, Tu MJ, Han F, Liu Z, Batra N, Lara PN, Chen HW, Bi H, Yu AM. PMID: 37799388; PMCID: PMC10547963.
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Recent Advances in Novel Recombinant RNAs for Studying Post-transcriptional Gene Regulation in Drug Metabolism and Disposition. Curr Drug Metab. 2023; 24(3):175-189.
Tu MJ, Yu AM. PMID: 37170982.
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PubMed Mentions: Fields:
Translation:
Humans
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ATR Inhibition in Advanced Urothelial Carcinoma. Clin Genitourin Cancer. 2023 04; 21(2):203-207.
Leibrandt RC, Tu MJ, Yu AM, Lara PN, Parikh M. PMID: 36604210.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Unrelated cord blood transplantation vs. HLA-matched sibling transplantation for adults with B-cell acute lymphoblastic leukemia in complete remission: superior OS for patients with long-term survival. Stem Cell Res Ther. 2022 10 09; 13(1):500.
Sun G, Tang B, Song K, Wu Y, Tu M, Wan X, Yao W, Geng L, Qiang P, Zhu X. PMID: 36210439; PMCID: PMC9549614.
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PubMed Mentions: Fields:
Translation:
Humans
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The clinical influence of preformed nonspecific anti-HLA antibodies on single-unit umbilical cord blood transplantation in patients with haematological malignancies. Br J Haematol. 2022 08; 198(4):e63-e66.
Wu Y, Tang B, Song K, Sun G, Tu M, Wan X, Yao W, Qiang P, Pan T, Ding P, Zhu X. PMID: 35715873.
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Translation:
Humans
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Allogeneic double-negative T cell therapy for relapsed acute myeloid leukemia patients post allogeneic hematopoietic stem cell transplantation: A first-in-human phase I study. Am J Hematol. 2022 07; 97(7):E264-E267.
Tang B, Lee JB, Cheng S, Pan T, Yao W, Wang D, Tu M, Xiang Z, Chu X, Geng L, Qiang P, Teng P, Sun G, Liu H, Wang J, Schimmer AD, Yang L, Sun Z, Zhang L, Zhu X. PMID: 35385187.
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PubMed Mentions:
1 Fields:
Translation:
HumansCTClinical Trials
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Bioengineered RNA Therapy in Patient-Derived Organoids and Xenograft Mouse Models. Methods Mol Biol. 2022; 2521:191-206.
Tu MJ, Yi CM, Traber GM, Yu AM. PMID: 35732999; PMCID: PMC9484490.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Chimeric Antigen Receptor T Cell Therapy followed by Unrelated Cord Blood Transplantation for the Treatment of Relapsed/Refractory B Cell Acute Lymphoblastic Leukemia in Children and Young Adults: Superior Survival but Relatively High Post-Transplantation Relapse. Transplant Cell Ther. 2022 02; 28(2):71.e1-71.e8.
Sun G, Tang B, Wan X, Yao W, Song K, Tu M, Geng L, Qiang P, Wu Y, Zhu L, Wu Y, Liu H, Zhu X, Sun Z. PMID: 34839013.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Poor survival and prediction of prolonged isolated thrombocytopenia post umbilical cord blood transplantation in patients with hematological malignancies. Hematol Oncol. 2022 Feb; 40(1):82-91.
Wu Y, Zhang Z, Tu M, Pan T, Ding P, Tang B, Wan X, Yao W, Song K, Sun G, Geng L, Qiang P, Liu H, Zhu X, Sun Z. PMID: 34664735.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Deliver the promise: RNAs as a new class of molecular entities for therapy and vaccination. Pharmacol Ther. 2022 02; 230:107967.
Yu AM, Tu MJ. PMID: 34403681; PMCID: PMC9477512.
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PubMed Mentions:
22 Fields:
Translation:
HumansCellsPHPublic Health
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A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to Evaluate Combination Therapy and Determine In Vivo Synergism. J Pharmacol Exp Ther. 2021 06; 377(3):305-315.
Choi YH, Zhang C, Liu Z, Tu MJ, Yu AX, Yu AM. PMID: 33712506; PMCID: PMC8140393.
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PubMed Mentions:
3 Fields:
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Single bioengineered ncRNA molecule for dual-targeting toward the control of non-small cell lung cancer patient-derived xenograft tumor growth. Biochem Pharmacol. 2021 07; 189:114392.
Petrek H, Yan Ho P, Batra N, Tu MJ, Zhang Q, Qiu JX, Yu AM. PMID: 33359565; PMCID: PMC8187260.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
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Expression and Purification of tRNA/ pre-miRNA-Based Recombinant Noncoding RNAs. Methods Mol Biol. 2021; 2323:249-265.
Tu MJ, Wright HK, Batra N, Yu AM. PMID: 34086286; PMCID: PMC9516694.
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PubMed Mentions:
4 Fields:
Translation:
CellsPHPublic Health
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Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability. Drug Metab Dispos. 2020 12; 48(12):1257-1263.
Jilek JL, Tu MJ, Zhang C, Yu AM. PMID: 33051247; PMCID: PMC7684025.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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MicroRNA-1291-5p Sensitizes Pancreatic Carcinoma Cells to Arginine Deprivation and Chemotherapy through the Regulation of Arginolysis and Glycolysis. Mol Pharmacol. 2020 12; 98(6):686-694.
Tu MJ, Duan Z, Liu Z, Zhang C, Bold RJ, Gonzalez FJ, Kim EJ, Yu AM. PMID: 33051382; PMCID: PMC7673485.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges. Pharmacol Rev. 2020 10; 72(4):862-898.
Yu AM, Choi YH, Tu MJ. PMID: 32929000; PMCID: PMC7495341.
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PubMed Mentions:
89 Fields:
Translation:
HumansCellsPHPublic Health
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A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis. Theranostics. 2020; 10(16):7193-7210.
Chen Y, Zhou Y, Han F, Zhao Y, Tu M, Wang Y, Huang C, Fan S, Chen P, Yao X, Guan L, Yu AM, Gonzalez FJ, Huang M, Bi H. PMID: 32641987; PMCID: PMC7330864.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Novel approaches for efficient in vivo fermentation production of noncoding RNAs. Appl Microbiol Biotechnol. 2020 Mar; 104(5):1927-1937.
Yu AM, Batra N, Tu MJ, Sweeney C. PMID: 31953559; PMCID: PMC7385725.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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Bioengineering of a single long noncoding RNA molecule that carries multiple small RNAs. Appl Microbiol Biotechnol. 2019 Aug; 103(15):6107-6117.
Petrek H, Batra N, Ho PY, Tu MJ, Yu AM. PMID: 31187211; PMCID: PMC7068804.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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A reliable LC-MS/MS method for the quantification of natural amino acids in mouse plasma: Method validation and application to a study on amino acid dynamics during hepatocellular carcinoma progression. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Aug 15; 1124:72-81.
Liu Z, Tu MJ, Zhang C, Jilek JL, Zhang QY, Yu AM. PMID: 31177050; PMCID: PMC6626562.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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Novel Synergistic Combination of Mitotic Arrest and Promotion of Apoptosis for Treatment of Pancreatic Adenocarcinoma. Transl Oncol. 2019 Apr; 12(4):683-692.
Duan Z, Chinn D, Tu MJ, Zhang QY, Huynh J, Chen J, Mack P, Yu AM, Kim EJ. PMID: 30844579; PMCID: PMC6402293.
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PubMed Mentions:
9
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Bioengineered Let-7c Inhibits Orthotopic Hepatocellular Carcinoma and Improves Overall Survival with Minimal Immunogenicity. Mol Ther Nucleic Acids. 2019 Mar 01; 14:498-508.
Jilek JL, Zhang QY, Tu MJ, Ho PY, Duan Z, Qiu JX, Yu AM. PMID: 30753993; PMCID: PMC6370598.
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PubMed Mentions:
26
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RNA therapy: Are we using the right molecules? Pharmacol Ther. 2019 04; 196:91-104.
Yu AM, Jian C, Yu AH, Tu MJ. PMID: 30521885; PMCID: PMC6450780.
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PubMed Mentions:
69 Fields:
Translation:
HumansAnimals
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Co-administration of nuciferine reduces the concentration of metformin in liver via differential inhibition of hepatic drug transporter OCT1 and MATE1. Biopharm Drug Dispos. 2018 Nov; 39(9):411-419.
Li L, Lei H, Wang W, Du W, Yuan J, Tu M, Zhou H, Zeng S, Jiang H. PMID: 30294927.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models. Cancer Lett. 2019 02 01; 442:82-90.
Tu MJ, Ho PY, Zhang QY, Jian C, Qiu JX, Kim EJ, Bold RJ, Gonzalez FJ, Bi H, Yu AM. PMID: 30389433; PMCID: PMC6311422.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Lipidation of polyethylenimine-based polyplex increases serum stability of bioengineered RNAi agents and offers more consistent tumoral gene knockdown in vivo. Int J Pharm. 2018 Aug 25; 547(1-2):537-544.
Zhang QY, Ho PY, Tu MJ, Jilek JL, Chen QX, Zeng S, Yu AM. PMID: 29894758; PMCID: PMC6388695.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Bioengineered Noncoding RNAs Selectively Change Cellular miRNome Profiles for Cancer Therapy. J Pharmacol Exp Ther. 2018 06; 365(3):494-506.
Ho PY, Duan Z, Batra N, Jilek JL, Tu MJ, Qiu JX, Hu Z, Wun T, Lara PN, DeVere White RW, Chen HW, Yu AM. PMID: 29602831; PMCID: PMC5931433.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Bioengineered NRF2-siRNA Is Effective to Interfere with NRF2 Pathways and Improve Chemosensitivity of Human Cancer Cells. Drug Metab Dispos. 2018 01; 46(1):2-10.
Li PC, Tu MJ, Ho PY, Jilek JL, Duan Z, Zhang QY, Yu AX, Yu AM. PMID: 29061583; PMCID: PMC5733456.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis. Oncotarget. 2016 Jul 19; 7(29):45547-45561.
Tu MJ, Pan YZ, Qiu JX, Kim EJ, Yu AM. PMID: 27322206; PMCID: PMC5216741.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy. Drug Metab Dispos. 2016 Mar; 44(3):308-19.
Yu AM, Tian Y, Tu MJ, Ho PY, Jilek JL. PMID: 26566807; PMCID: PMC4767381.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Combination therapy with bioengineered miR-34a prodrug and doxorubicin synergistically suppresses osteosarcoma growth. Biochem Pharmacol. 2015 Dec 15; 98(4):602-13.
Zhao Y, Tu MJ, Yu YF, Wang WP, Chen QX, Qiu JX, Yu AX, Yu AM. PMID: 26518752; PMCID: PMC4725324.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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Chimeric MicroRNA-1291 Biosynthesized Efficiently in Escherichia coli Is Effective to Reduce Target Gene Expression in Human Carcinoma Cells and Improve Chemosensitivity. Drug Metab Dispos. 2015 Jul; 43(7):1129-36.
Li MM, Addepalli B, Tu MJ, Chen QX, Wang WP, Limbach PA, LaSalle JM, Zeng S, Huang M, Yu AM. PMID: 25934574; PMCID: PMC4468437.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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Simple and rapid determination of unsaturated fatty acids in 1 µl of rat plasma by LC-MS/MS. Bioanalysis. 2015; 7(9):1081-91.
Zheng S, Ma Z, Song F, Ye J, Wang R, Tu M, Li L, Zhou H, Zeng S, Jiang H. PMID: 26039806.
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PubMed Mentions: Fields:
Translation:
Animals
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Involvement of organic cation transporter 1 and CYP3A4 in retrorsine-induced toxicity. Toxicology. 2014 Aug 01; 322:34-42.
Tu M, Li L, Lei H, Ma Z, Chen Z, Sun S, Xu S, Zhou H, Zeng S, Jiang H. PMID: 24799337.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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The contribution of human OCT1, OCT3, and CYP3A4 to nitidine chloride-induced hepatocellular toxicity. Drug Metab Dispos. 2014 Jul; 42(7):1227-34.
Li L, Tu M, Yang X, Sun S, Wu X, Zhou H, Zeng S, Jiang H. PMID: 24778366.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Involvement of organic cation transporter 2 inhibition in potential mechanisms of antidepressant action. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Aug 04; 53:90-8.
Wang K, Sun S, Li L, Tu M, Jiang H. PMID: 24657329.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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In vitro interaction of clopidogrel and its hydrolysate with OCT1, OCT2 and OAT1. Int J Pharm. 2014 Apr 25; 465(1-2):5-10.
Li L, Song F, Tu M, Wang K, Zhao L, Wu X, Zhou H, Xia Z, Jiang H. PMID: 24530383.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 03; 49:1-6.
Sun S, Wang K, Lei H, Li L, Tu M, Zeng S, Zhou H, Jiang H. PMID: 24246570.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity. Toxicology. 2013 Sep 15; 311(3):225-30.
Tu M, Sun S, Wang K, Peng X, Wang R, Li L, Zeng S, Zhou H, Jiang H. PMID: 23831208.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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The exposure of luteolin is much lower than that of apigenin in oral administration of Flos Chrysanthemi extract to rats. Drug Metab Pharmacokinet. 2012; 27(1):162-8.
Chen Z, Tu M, Sun S, Kong S, Wang Y, Ye J, Li L, Zeng S, Jiang H. PMID: 21931223.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells