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Janine M LaSalle, PhD

Title(s)Professor, Medical Microbiology And Immunology
SchoolUniversity of California, Davis
Phone530-754-7598
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    Collapse Research 
    Collapse Research Activities and Funding
    Imprinted snoRNA loci and circadian entrainment
    NIH/NICHD R01HD098038Jan 15, 2019 - Dec 31, 2023
    Role: Principal Investigator
    Neuroimmune interactions in Rett syndrome
    NIH/NIAAA R01AA027075Sep 10, 2018 - Jun 30, 2023
    Role: Principal Investigator
    PCB Epigenomic Brain & Behavior Lasting Effects Study (PEBBLES)
    NIH/NIEHS R01ES029213Jun 1, 2018 - May 31, 2023
    Role: Principal Investigator
    Methylomic and genomic impacts of organic pollutants in Dup15q syndrome
    NIH/NIEHS R56ES021707Jun 12, 2012 - Sep 29, 2018
    Role: Principal Investigator
    Methylomic and genomic impacts of organic pollutants in Dup15q syndrome
    NIH/NIEHS R01ES021707Jun 12, 2012 - Feb 28, 2017
    Role: Principal Investigator
    Noncoding RNAs at the heart of the Prader-Willi locus
    NIH/NINDS R56NS076263Aug 1, 2011 - Sep 24, 2018
    Role: Principal Investigator
    Noncoding RNAs at the heart of the Prader-Willi locus
    NIH/NINDS R01NS076263Aug 1, 2011 - Jul 31, 2016
    Role: Principal Investigator
    iCys Laser Scanning Cytometer for UC Davis Core
    NIH/NCRR S10RR024747Apr 18, 2008 - Apr 17, 2009
    Role: Principal Investigator
    Epigenetic Interaction of MECP2 and Organic Pollutants in Neurodevelopment
    NIH/NIEHS R01ES015171Sep 25, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Epigenetic Etiologies of Autism-Spectrum Disorders
    NIH/NICHD R01HD048799Aug 10, 2005 - May 30, 2011
    Role: Principal Investigator
    The Role of MeCP2 in Rett Syndrome
    NIH/NINDS R01NS081913Dec 1, 2001 - Jul 31, 2017
    Role: Principal Investigator
    The Role of MeCP2 in Rett Syndrome
    NIH/NICHD R01HD041462Dec 1, 2001 - May 31, 2013
    Role: Principal Investigator
    LSC ANALYSIS OF CELL CYCLE REGULATED CHROMOSOME DYNAMICS
    NIH/NCI R21CA078851Sep 30, 1998 - Aug 31, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lopez SJ, Laufer BI, Beitnere U, Berg EL, Silverman JL, O'Geen H, Segal DJ, LaSalle JM. Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways. Hum Mol Genet. 2019 Nov 15; 28(22):3842-3852. PMID: 31625566.
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    2. Mordaunt CE, Park BY, Bakulski KM, Feinberg JI, Croen LA, Ladd-Acosta C, Newschaffer CJ, Volk HE, Ozonoff S, Hertz-Picciotto I, LaSalle JM, Schmidt RJ, Fallin MD. A meta-analysis of two high-risk prospective cohort studies reveals autism-specific transcriptional changes to chromatin, autoimmune, and environmental response genes in umbilical cord blood. Mol Autism. 2019; 10:36. PMID: 31673306.
      View in: PubMed
    3. Zhu Y, Mordaunt CE, Yasui DH, Marathe R, Coulson RL, Dunaway KW, Jianu JM, Walker CK, Ozonoff S, Hertz-Picciotto I, Schmidt RJ, LaSalle JM. Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study. Hum Mol Genet. 2019 08 15; 28(16):2659-2674. PMID: 31009952.
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    4. Laufer BI, Hwang H, Vogel Ciernia A, Mordaunt CE, LaSalle JM. Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disorder insights. Epigenetics. 2019 Jul; 14(7):672-684. PMID: 31010359.
      View in: PubMed
    5. Medici V, LaSalle JM. Genetics and epigenetic factors of Wilson disease. Ann Transl Med. 2019 Apr; 7(Suppl 2):S58. PMID: 31179295.
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    6. Mordaunt CE, Kieffer DA, Shibata NM, Czlonkowska A, Litwin T, Weiss KH, Zhu Y, Bowlus CL, Sarkar S, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V. Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers. Epigenetics Chromatin. 2019 02 01; 12(1):10. PMID: 30709419.
      View in: PubMed
    7. Lopez SJ, Segal DJ, LaSalle JM. UBE3A: An E3 Ubiquitin Ligase With Genome-Wide Impact in Neurodevelopmental Disease. Front Mol Neurosci. 2018; 11:476. PMID: 30686997.
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    8. Coulson RL, Powell WT, Yasui DH, Dileep G, Resnick J, LaSalle JM. Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN. Hum Mol Genet. 2018 12 01; 27(23):4051-4060. PMID: 30124848.
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    9. Vogel Ciernia A, Yasui DH, Pride MC, Durbin-Johnson B, Noronha AB, Chang A, Knotts TA, Rutkowsky JR, Ramsey JJ, Crawley JN, LaSalle JM. MeCP2 isoform e1 mutant mice recapitulate motor and metabolic phenotypes of Rett syndrome. Hum Mol Genet. 2018 12 01; 27(23):4077-4093. PMID: 30137367.
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    10. Mordaunt CE, Shibata NM, Kieffer DA, Czlonkowska A, Litwin T, Weiss KH, Gotthardt DN, Olson K, Wei D, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V. Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease. Hum Mol Genet. 2018 11 15; 27(22):3854-3869. PMID: 30010856.
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    11. Hertz-Picciotto I, Schmidt RJ, Walker CK, Bennett DH, Oliver M, Shedd-Wise KM, LaSalle JM, Giulivi C, Puschner B, Thomas J, Roa DL, Pessah IN, Van de Water J, Tancredi DJ, Ozonoff S. A Prospective Study of Environmental Exposures and Early Biomarkers in Autism Spectrum Disorder: Design, Protocols, and Preliminary Data from the MARBLES Study. Environ Health Perspect. 2018 11; 126(11):117004. PMID: 30465702.
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    12. Adhikari A, Copping NA, Onaga B, Pride MC, Coulson RL, Yang M, Yasui DH, LaSalle JM, Silverman JL. Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome. Neurobiol Learn Mem. 2019 11; 165:106874. PMID: 29800646.
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    13. Vogel Ciernia A, Laufer BI, Dunaway KW, Mordaunt CE, Coulson RL, Totah TS, Stolzenberg DS, Frahm JC, Singh-Taylor A, Baram TZ, LaSalle JM, Yasui DH. Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches. Epigenetics. 2018; 13(3):318-330. PMID: 29613827.
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    14. Coulson RL, Yasui DH, Dunaway KW, Laufer BI, Vogel Ciernia A, Zhu Y, Mordaunt CE, Totah TS, LaSalle JM. Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex. Nat Commun. 2018 04 24; 9(1):1616. PMID: 29691382.
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    15. Coulson RL, LaSalle JM. Epigenetics of Circadian Rhythms in Imprinted Neurodevelopmental Disorders. Prog Mol Biol Transl Sci. 2018; 157:67-92. PMID: 29933957.
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    16. Dou J, Schmidt RJ, Benke KS, Newschaffer C, Hertz-Picciotto I, Croen LA, Iosif AM, LaSalle JM, Fallin MD, Bakulski KM. Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation. Epigenetics. 2018; 13(1):108-116. PMID: 29451060.
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    17. Vogel Ciernia A, Careaga M, LaSalle JM, Ashwood P. Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autism. Glia. 2018 03; 66(3):505-521. PMID: 29134693.
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    18. Lopez SJ, Dunaway K, Islam MS, Mordaunt C, Vogel Ciernia A, Meguro-Horike M, Horike SI, Segal DJ, LaSalle JM. UBE3A-mediated regulation of imprinted genes and epigenome-wide marks in human neurons. Epigenetics. 2017; 12(11):982-990. PMID: 28925810.
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    19. Copping NA, Christian SGB, Ritter DJ, Islam MS, Buscher N, Zolkowska D, Pride MC, Berg EL, LaSalle JM, Ellegood J, Lerch JP, Reiter LT, Silverman JL, Dindot SV. Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome. Hum Mol Genet. 2017 10 15; 26(20):3995-4010. PMID: 29016856.
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    20. Vogel Ciernia A, Pride MC, Durbin-Johnson B, Noronha A, Chang A, Yasui DH, Crawley JN, LaSalle JM. Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering. Hum Mol Genet. 2017 05 15; 26(10):1839-1854. PMID: 28334953.
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    21. Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environ Health Perspect. 2017 04; 125(4):511-526. PMID: 28362264.
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    22. Dunaway K, Goorha S, Matelski L, Urraca N, Lein PJ, Korf I, Reiter LT, LaSalle JM. Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns. Stem Cells. 2017 04; 35(4):981-988. PMID: 28032673.
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    23. Crary-Dooley FK, Tam ME, Dunaway KW, Hertz-Picciotto I, Schmidt RJ, LaSalle JM. A comparison of existing global DNA methylation assays to low-coverage whole-genome bisulfite sequencing for epidemiological studies. Epigenetics. 2017 03 04; 12(3):206-214. PMID: 28055307.
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    24. Schroeder DI, Schmidt RJ, Crary-Dooley FK, Walker CK, Ozonoff S, Tancredi DJ, Hertz-Picciotto I, LaSalle JM. Placental methylome analysis from a prospective autism study. Mol Autism. 2016; 7:51. PMID: 28018572.
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    25. Dunaway KW, Islam MS, Coulson RL, Lopez SJ, Vogel Ciernia A, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike SI, Korf I, LaSalle JM. Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes. Cell Rep. 2016 12 13; 17(11):3035-3048. PMID: 27974215.
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    26. Schmidt RJ, Schroeder DI, Crary-Dooley FK, Barkoski JM, Tancredi DJ, Walker CK, Ozonoff S, Hertz-Picciotto I, LaSalle JM. Self-reported pregnancy exposures and placental DNA methylation in the MARBLES prospective autism sibling study. Environ Epigenet. 2016 Dec; 2(4). PMID: 28781890.
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    27. Medici V, Kieffer DA, Shibata NM, Chima H, Kim K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda KK, Olson K, Su RJ, Islam MS, Syed R, Keen CL, Miller AY, Rutledge JC, Halsted CH, LaSalle JM. Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model. Epigenetics. 2016 Nov; 11(11):804-818. PMID: 27611852.
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    28. Veeraragavan S, Wan YW, Connolly DR, Hamilton SM, Ward CS, Soriano S, Pitcher MR, McGraw CM, Huang SG, Green JR, Yuva LA, Liang AJ, Neul JL, Yasui DH, LaSalle JM, Liu Z, Paylor R, Samaco RC. Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome. Hum Mol Genet. 2016 08 01; 25(15):3284-3302. PMID: 27365498.
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    29. Vogel Ciernia A, LaSalle J. The landscape of DNA methylation amid a perfect storm of autism aetiologies. Nat Rev Neurosci. 2016 07; 17(7):411-23. PMID: 27150399.
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    30. Rube HT, Lee W, Hejna M, Chen H, Yasui DH, Hess JF, LaSalle JM, Song JS, Gong Q. Sequence features accurately predict genome-wide MeCP2 binding in vivo. Nat Commun. 2016 Mar 24; 7:11025. PMID: 27008915.
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    31. Crawley JN, Heyer WD, LaSalle JM. Autism and Cancer Share Risk Genes, Pathways, and Drug Targets. Trends Genet. 2016 Mar; 32(3):139-146. PMID: 26830258.
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    32. LaSalle JM, Reiter LT, Chamberlain SJ. Epigenetic regulation of UBE3A and roles in human neurodevelopmental disorders. Epigenomics. 2015 Oct; 7(7):1213-28. PMID: 26585570.
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    33. Schroeder DI, Jayashankar K, Douglas KC, Thirkill TL, York D, Dickinson PJ, Williams LE, Samollow PB, Ross PJ, Bannasch DL, Douglas GC, LaSalle JM. Early Developmental and Evolutionary Origins of Gene Body DNA Methylation Patterns in Mammalian Placentas. PLoS Genet. 2015 Aug; 11(8):e1005442. PMID: 26241857.
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    34. Powell WT, LaSalle JM. Epigenetic mechanisms in diurnal cycles of metabolism and neurodevelopment. Hum Mol Genet. 2015 Oct 15; 24(R1):R1-9. PMID: 26105183.
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    35. Li MM, Addepalli B, Tu MJ, Chen QX, Wang WP, Limbach PA, LaSalle JM, Zeng S, Huang M, Yu AM. Chimeric MicroRNA-1291 Biosynthesized Efficiently in Escherichia coli Is Effective to Reduce Target Gene Expression in Human Carcinoma Cells and Improve Chemosensitivity. Drug Metab Dispos. 2015 Jul; 43(7):1129-36. PMID: 25934574.
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    36. Carlo Selmi, Francesca Cavaciocchi, Ana Lleo, Cristina Cheroni, Raffaele De Francesco, Simone A. Lombardi, Maria De Santis, Francesca Meda, Maria Gabriella Raimondo, Chiara Crotti, Marco Folci, Luca Zammataro, Marlyn J. Mayo, Nancy Bach, Shinji Shimoda, Stuart C. Gordon, Monica Miozzo, Pietro Invernizzi, Mauro Podda, Rossana Scavelli, Michelle R. Martin, Michael F. Seldin, Janine M. LaSalle, M. Eric Gershwin. Corrigendum: Genome-Wide Analysis of DNA Methylation, Copy Number Variation, and Gene Expression in Monozygotic Twins Discordant for Primary Biliary Cirrhosis. Frontiers in Immunology. 2014 Aug 14; 5:371.
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    37. Lee W, Yun JM, Woods R, Dunaway K, Yasui DH, Lasalle JM, Gong Q. MeCP2 regulates activity-dependent transcriptional responses in olfactory sensory neurons. Hum Mol Genet. 2014 Dec 01; 23(23):6366-74. PMID: 25008110.
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    38. Janine M. LaSalle, Keith W. Dunaway. The Potential Brain Drain from Environmental Exposures on the Methylome and Genome Across Generations. 2014 Jul 1; 375-406.
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    39. Le A, Shibata NM, French SW, Kim K, Kharbanda KK, Islam MS, LaSalle JM, Halsted CH, Keen CL, Medici V. Characterization of timed changes in hepatic copper concentrations, methionine metabolism, gene expression, and global DNA methylation in the Jackson toxic milk mouse model of Wilson disease. Int J Mol Sci. 2014 May 07; 15(5):8004-23. PMID: 24810691.
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    40. Medici V, Schroeder DI, Woods R, LaSalle JM, Geng Y, Shibata NM, Peerson J, Hodzic E, Dayal S, Tsukamoto H, Kharbanda KK, Tillman B, French SW, Halsted CH. Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse. Alcohol Clin Exp Res. 2014 Jun; 38(6):1540-9. PMID: 24730561.
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    41. Selmi C, Cavaciocchi F, Lleo A, Cheroni C, De Francesco R, Lombardi SA, De Santis M, Meda F, Raimondo MG, Crotti C, Folci M, Zammataro L, Mayo MJ, Bach N, Shimoda S, Gordon SC, Miozzo M, Invernizzi P, Podda M, Scavelli R, Martin MR, Seldin MF, Lasalle JM, Gershwin ME. Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis. Front Immunol. 2014; 5:128. PMID: 24734033.
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    42. Conant KD, Finucane B, Cleary N, Martin A, Muss C, Delany M, Murphy EK, Rabe O, Luchsinger K, Spence SJ, Schanen C, Devinsky O, Cook EH, LaSalle J, Reiter LT, Thibert RL. A survey of seizures and current treatments in 15q duplication syndrome. Epilepsia. 2014 Mar; 55(3):396-402. PMID: 24502430.
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    43. Yasui DH, Gonzales ML, Aflatooni JO, Crary FK, Hu DJ, Gavino BJ, Golub MS, Vincent JB, Carolyn Schanen N, Olson CO, Rastegar M, Lasalle JM. Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome. Hum Mol Genet. 2014 May 01; 23(9):2447-58. PMID: 24352790.
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    44. Schroeder DI, LaSalle JM. How has the study of the human placenta aided our understanding of partially methylated genes? Epigenomics. 2013 Dec; 5(6):645-54. PMID: 24283879.
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    45. Medici V, Shibata NM, Kharbanda KK, Islam MS, Keen CL, Kim K, Tillman B, French SW, Halsted CH, LaSalle JM. Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the tx-j mouse model of Wilson disease. Epigenetics. 2014 Feb; 9(2):286-96. PMID: 24220304.
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    46. Powell WT, Coulson RL, Gonzales ML, Crary FK, Wong SS, Adams S, Ach RA, Tsang P, Yamada NA, Yasui DH, Chédin F, LaSalle JM. R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13938-43. PMID: 23918391.
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    47. Lasalle JM. Autism genes keep turning up chromatin. OA Autism. 2013 Jun 19; 1(2):14. PMID: 24404383.
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    48. Powell WT, Coulson RL, Crary FK, Wong SS, Ach RA, Tsang P, Alice Yamada N, Yasui DH, Lasalle JM. A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure. Hum Mol Genet. 2013 Nov 01; 22(21):4318-28. PMID: 23771028.
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    49. LaSalle JM, Powell WT, Yasui DH. Epigenetic layers and players underlying neurodevelopment. Trends Neurosci. 2013 Aug; 36(8):460-70. PMID: 23731492.
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    50. LaSalle JM. Epigenomic strategies at the interface of genetic and environmental risk factors for autism. J Hum Genet. 2013 Jul; 58(7):396-401. PMID: 23677056.
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    51. Schroeder DI, Blair JD, Lott P, Yu HO, Hong D, Crary F, Ashwood P, Walker C, Korf I, Robinson WP, LaSalle JM. The human placenta methylome. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):6037-42. PMID: 23530188.
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    52. Yasui DH, Xu H, Dunaway KW, Lasalle JM, Jin LW, Maezawa I. MeCP2 modulates gene expression pathways in astrocytes. Mol Autism. 2013 Jan 25; 4(1):3. PMID: 23351786.
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    53. Medici V, Shibata NM, Kharbanda KK, LaSalle JM, Woods R, Liu S, Engelberg JA, Devaraj S, Török NJ, Jiang JX, Havel PJ, Lönnerdal B, Kim K, Halsted CH. Wilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease. Hepatology. 2013 Feb; 57(2):555-65. PMID: 22945834.
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    54. Janine M. LaSalle, Mohammad Saharul Islam. Recurrent CNVs in the Etiology of Epigenetic Neurodevelopmental Disorders. 2013 Jan 1; 147-178.
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    55. Weston T. Powell, Janine M. LaSalle. Chapter 10 Imprinting in the CNS and Neurodevelopmental Disorders. 2013 Jan 1; 267-279.
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    56. Sarrita Adams, Janine M. LaSalle. Chapter 4.6 MeCP2 and Autism Spectrum Disorders. 2013 Jan 1; 421-436.
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    57. Selmi C, Feghali-Bostwick CA, Lleo A, Lombardi SA, De Santis M, Cavaciocchi F, Zammataro L, Mitchell MM, Lasalle JM, Medsger T, Gershwin ME. X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma. Clin Exp Immunol. 2012 Sep; 169(3):253-62. PMID: 22861365.
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    58. Mitchell MM, Woods R, Chi LH, Schmidt RJ, Pessah IN, Kostyniak PJ, LaSalle JM. Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder. Environ Mol Mutagen. 2012 Oct; 53(8):589-98. PMID: 22930557.
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    59. Gonzales ML, Adams S, Dunaway KW, LaSalle JM. Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation. Mol Cell Biol. 2012 Jul; 32(14):2894-903. PMID: 22615490.
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    60. Rosangela Artuso, Filomena T Papa, Elisa Grillo, Mafalda Mucciolo, Dag H Yasui, Keith W Dunaway, Vittoria Disciglio, Maria A Mencarelli, Marzia Pollazzon, Michele Zappella, Giuseppe Hayek, Francesca Mari, Alessandra Renieri, Janine M LaSalle, Francesca Ariani. Erratum: Investigation of modifier genes within copy number variations in Rett syndrome. Journal of Human Genetics. 2012 May 1; 57(5):342-344.
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    61. Woods R, Vallero RO, Golub MS, Suarez JK, Ta TA, Yasui DH, Chi LH, Kostyniak PJ, Pessah IN, Berman RF, LaSalle JM. Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation. Hum Mol Genet. 2012 Jun 01; 21(11):2399-411. PMID: 22343140.
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    62. Rima Woods, Janine M. LaSalle. Epigenetic Epidemiology of Autism and Other Neurodevelopmental Disorders. 2012 Jan 1; 321-342.
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    63. Martins-Taylor K, Schroeder DI, LaSalle JM, Lalande M, Xu RH. Role of DNMT3B in the regulation of early neural and neural crest specifiers. Epigenetics. 2012 Jan 01; 7(1):71-82. PMID: 22207353.
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    64. Scoles HA, Urraca N, Chadwick SW, Reiter LT, Lasalle JM. Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples. Mol Autism. 2011 Dec 12; 2(1):19. PMID: 22152151.
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    65. Yasui DH, Scoles HA, Horike S, Meguro-Horike M, Dunaway KW, Schroeder DI, Lasalle JM. 15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain. Hum Mol Genet. 2011 Nov 15; 20(22):4311-23. PMID: 21840925.
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    66. Schroeder DI, Lott P, Korf I, LaSalle JM. Large-scale methylation domains mark a functional subset of neuronally expressed genes. Genome Res. 2011 Oct; 21(10):1583-91. PMID: 21784875.
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    67. LaSalle JM. A genomic point-of-view on environmental factors influencing the human brain methylome. Epigenetics. 2011 Jul; 6(7):862-9. PMID: 21617367.
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    68. Meguro-Horike M, Yasui DH, Powell W, Schroeder DI, Oshimura M, Lasalle JM, Horike S. Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome. Hum Mol Genet. 2011 Oct 01; 20(19):3798-810. PMID: 21725066.
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    69. Artuso R, Papa FT, Grillo E, Mucciolo M, Yasui DH, Dunaway KW, Disciglio V, Mencarelli MA, Pollazzon M, Zappella M, Hayek G, Mari F, Renieri A, Lasalle JM, Ariani F. Investigation of modifier genes within copy number variations in Rett syndrome. J Hum Genet. 2011 Jul; 56(7):508-15. PMID: 21593744.
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    70. Singleton MK, Gonzales ML, Leung KN, Yasui DH, Schroeder DI, Dunaway K, LaSalle JM. MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation. Neurobiol Dis. 2011 Jul; 43(1):190-200. PMID: 21420494.
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    71. Leung KN, Chamberlain SJ, Lalande M, LaSalle JM. Neuronal chromatin dynamics of imprinting in development and disease. J Cell Biochem. 2011 Feb; 112(2):365-73. PMID: 21268055.
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    72. Robert F. Berman, Claire M. Koenig, Michael R. Hunsaker, Isaac N. Pessah, Janine M. Lasalle. Neurodevelopmental Toxicology and Autism Spectrum Disorders. 2011 Jan 14; 439-476.
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    73. Mitchell MM, Lleo A, Zammataro L, Mayo MJ, Invernizzi P, Bach N, Shimoda S, Gordon S, Podda M, Gershwin ME, Selmi C, LaSalle JM. Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis. Epigenetics. 2011 Jan; 6(1):95-102. PMID: 20864813.
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    74. Gonzales ML, LaSalle JM. The role of MeCP2 in brain development and neurodevelopmental disorders. Curr Psychiatry Rep. 2010 Apr; 12(2):127-34. PMID: 20425298.
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    75. Amber Hogart, Janine M. LaSalle. Epigenetic Dysregulation of 15q11-13 GABAA Receptor Genes in Autism. 2010 Jan 1; 113-127.
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    76. LaSalle JM, Yasui DH. Evolving role of MeCP2 in Rett syndrome and autism. Epigenomics. 2009 Oct; 1(1):119-30. PMID: 20473347.
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    77. Leung KN, Vallero RO, DuBose AJ, Resnick JL, LaSalle JM. Imprinting regulates mammalian snoRNA-encoding chromatin decondensation and neuronal nucleolar size. Hum Mol Genet. 2009 Nov 15; 18(22):4227-38. PMID: 19656775.
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    78. Maezawa I, Swanberg S, Harvey D, LaSalle JM, Jin LW. Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions. J Neurosci. 2009 Apr 22; 29(16):5051-61. PMID: 19386901.
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    79. Swanberg SE, Nagarajan RP, Peddada S, Yasui DH, LaSalle JM. Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism. Hum Mol Genet. 2009 Feb 01; 18(3):525-34. PMID: 19000991.
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    80. Adegbola AA, Gonzales ML, Chess A, LaSalle JM, Cox GF. A novel hypomorphic MECP2 point mutation is associated with a neuropsychiatric phenotype. Hum Genet. 2009 Jan; 124(6):615-23. PMID: 18989701.
      View in: PubMed
    81. Hogart A, Leung KN, Wang NJ, Wu DJ, Driscoll J, Vallero RO, Schanen NC, LaSalle JM. Chromosome 15q11-13 duplication syndrome brain reveals epigenetic alterations in gene expression not predicted from copy number. J Med Genet. 2009 Feb; 46(2):86-93. PMID: 18835857.
      View in: PubMed
    82. Hogart A, Wu D, LaSalle JM, Schanen NC. The comorbidity of autism with the genomic disorders of chromosome 15q11.2-q13. Neurobiol Dis. 2010 May; 38(2):181-91. PMID: 18840528.
      View in: PubMed
    83. Hogart A, Patzel KA, LaSalle JM. Gender influences monoallelic expression of ATP10A in human brain. Hum Genet. 2008 Oct; 124(3):235-42. PMID: 18726118.
      View in: PubMed
    84. Nagarajan RP, Patzel KA, Martin M, Yasui DH, Swanberg SE, Hertz-Picciotto I, Hansen RL, Van de Water J, Pessah IN, Jiang R, Robinson WP, LaSalle JM. MECP2 promoter methylation and X chromosome inactivation in autism. Autism Res. 2008 Jun; 1(3):169-78. PMID: 19132145.
      View in: PubMed
    85. Kumar A, Kamboj S, Malone BM, Kudo S, Twiss JL, Czymmek KJ, LaSalle JM, Schanen NC. Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo. J Cell Sci. 2008 Apr 01; 121(Pt 7):1128-37. PMID: 18334558.
      View in: PubMed
    86. Pessah IN, Seegal RF, Lein PJ, LaSalle J, Yee BK, Van De Water J, Berman RF. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology. 2008 May; 29(3):532-45. PMID: 18394707.
      View in: PubMed
    87. Wang NJ, Parokonny AS, Thatcher KN, Driscoll J, Malone BM, Dorrani N, Sigman M, LaSalle JM, Schanen NC. Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15. BMC Genet. 2008 Jan 04; 9:2. PMID: 18177502.
      View in: PubMed
    88. Yasui DH, Peddada S, Bieda MC, Vallero RO, Hogart A, Nagarajan RP, Thatcher KN, Farnham PJ, Lasalle JM. Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. Proc Natl Acad Sci U S A. 2007 Dec 04; 104(49):19416-21. PMID: 18042715.
      View in: PubMed
    89. Hogart A, Nagarajan RP, Patzel KA, Yasui DH, Lasalle JM. 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders. Hum Mol Genet. 2007 Mar 15; 16(6):691-703. PMID: 17339270.
      View in: PubMed
    90. LaSalle JM. The odyssey of MeCP2 and parental imprinting. Epigenetics. 2007 Jan-Mar; 2(1):5-10. PMID: 17486180; PMCID: PMC1866173.
    91. LaSalle JM. The Odyssey of MeCP2 and parental imprinting. Epigenetics. 2007 Jan-Mar; 2(1):5-10. PMID: 17965611.
      View in: PubMed
    92. Nagarajan RP, Hogart AR, Gwye Y, Martin MR, LaSalle JM. Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation. Epigenetics. 2006 Oct-Dec; 1(4):e1-11. PMID: 17486179.
      View in: PubMed
    93. Delgado IJ, Kim DS, Thatcher KN, LaSalle JM, Van den Veyver IB. Expression profiling of clonal lymphocyte cell cultures from Rett syndrome patients. BMC Med Genet. 2006 Jul 21; 7:61. PMID: 16859563.
      View in: PubMed
    94. Peddada S, Yasui DH, LaSalle JM. Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. Hum Mol Genet. 2006 Jun 15; 15(12):2003-14. PMID: 16682435.
      View in: PubMed
    95. Thatcher KN, LaSalle JM. Dynamic changes in Histone H3 lysine 9 acetylation localization patterns during neuronal maturation require MeCP2. Epigenetics. 2006 Jan-Mar; 1(1):24-31. PMID: 17464364.
      View in: PubMed
    96. Thatcher KN, Peddada S, Yasui DH, Lasalle JM. Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples. Hum Mol Genet. 2005 Mar 15; 14(6):785-97. PMID: 15689352.
      View in: PubMed
    97. LaSalle JM, Hogart A, Thatcher KN. Rett syndrome: a Rosetta stone for understanding the molecular pathogenesis of autism. Int Rev Neurobiol. 2005; 71:131-65. PMID: 16512349.
      View in: PubMed
    98. Samaco RC, Hogart A, LaSalle JM. Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3. Hum Mol Genet. 2005 Feb 15; 14(4):483-92. PMID: 15615769.
      View in: PubMed
    99. Braunschweig D, Simcox T, Samaco RC, LaSalle JM. X-Chromosome inactivation ratios affect wild-type MeCP2 expression within mosaic Rett syndrome and Mecp2-/+ mouse brain. Hum Mol Genet. 2004 Jun 15; 13(12):1275-86. PMID: 15115765.
      View in: PubMed
    100. Samaco RC, Nagarajan RP, Braunschweig D, LaSalle JM. Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders. Hum Mol Genet. 2004 Mar 15; 13(6):629-39. PMID: 14734626.
      View in: PubMed
    101. LaSalle JM. Paradoxical role of methyl-CpG-binding protein 2 in Rett syndrome. Curr Top Dev Biol. 2004; 59:61-86. PMID: 14975247.
      View in: PubMed
    102. Balmer D, Goldstine J, Rao YM, LaSalle JM. Elevated methyl-CpG-binding protein 2 expression is acquired during postnatal human brain development and is correlated with alternative polyadenylation. J Mol Med (Berl). 2003 Jan; 81(1):61-8. PMID: 12545250.
      View in: PubMed
    103. Gandour-Edwards R, Lara PN, Folkins AK, LaSalle JM, Beckett L, Li Y, Meyers FJ, DeVere-White R. Does HER2/neu expression provide prognostic information in patients with advanced urothelial carcinoma? Cancer. 2002 Sep 01; 95(5):1009-15. PMID: 12209684.
      View in: PubMed
    104. Balmer D, Arredondo J, Samaco RC, LaSalle JM. MECP2 mutations in Rett syndrome adversely affect lymphocyte growth, but do not affect imprinted gene expression in blood or brain. Hum Genet. 2002 Jun; 110(6):545-52. PMID: 12107440.
      View in: PubMed
    105. Liu HL, Gandour-Edwards R, Lara PN, de Vere White R, LaSalle JM. Detection of low level HER-2/neu gene amplification in prostate cancer by fluorescence in situ hybridization. Cancer J. 2001 Sep-Oct; 7(5):395-403. PMID: 11693898.
      View in: PubMed
    106. LaSalle JM, Goldstine J, Balmer D, Greco CM. Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometry. Hum Mol Genet. 2001 Aug 15; 10(17):1729-40. PMID: 11532982.
      View in: PubMed
    107. Douglas GC, Thirkill TL, LaSalle J. Automated quantitation of cell-mediated HIV type 1 infection of human syncytiotrophoblast cells by fluorescence in situ hybridization and laser scanning cytometry. AIDS Res Hum Retroviruses. 2001 Apr 10; 17(6):507-16. PMID: 11350664.
      View in: PubMed
    108. Balmer D, LaSalle JM. Clonal maintenance of imprinted expression of SNRPN and IPW in normal lymphocytes: correlation with allele-specific methylation of SNRPN intron 1 but not intron 7. Hum Genet. 2001 Feb; 108(2):116-22. PMID: 11281449.
      View in: PubMed
    109. LaSalle J, Lalande M. Flow cytometry and FISH to investigate allele-specific replication timing and homologous association of imprinted chromosomes. Methods Mol Biol. 2001; 181:181-92. PMID: 12843450.
      View in: PubMed
    110. LaSalle JM, Ritchie RJ, Glatt H, Lalande M. Clonal heterogeneity at allelic methylation sites diagnostic for Prader-Willi and Angelman syndromes. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1675-80. PMID: 9465075.
      View in: PubMed
    111. Strehl S, LaSalle JM, Lalande M. High-resolution analysis of DNA replication domain organization across an R/G-band boundary. Mol Cell Biol. 1997 Oct; 17(10):6157-66. PMID: 9315676.
      View in: PubMed
    112. Mizuta R, LaSalle JM, Cheng HL, Shinohara A, Ogawa H, Copeland N, Jenkins NA, Lalande M, Alt FW. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6927-32. PMID: 9192668.
      View in: PubMed
    113. LaSalle JM, Lalande M. Homologous association of oppositely imprinted chromosomal domains. Science. 1996 May 03; 272(5262):725-8. PMID: 8614834.
      View in: PubMed
    114. LaSalle JM, Lalande M. Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution. Nat Genet. 1995 Apr; 9(4):386-94. PMID: 7795644.
      View in: PubMed
    115. LaSalle JM, Hafler DA. T cell anergy. FASEB J. 1994 Jun; 8(9):601-8. PMID: 8005388.
      View in: PubMed
    116. LaSalle JM, Toneguzzo F, Saadeh M, Golan DE, Taber R, Hafler DA. T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen. J Immunol. 1993 Jul 15; 151(2):649-57. PMID: 7687620.
      View in: PubMed
    117. Oettinger HF, al-Sabbagh A, Jingwu Z, LaSalle JM, Weiner HL, Hafler DA. Biological activity of recombinant human myelin basic protein. J Neuroimmunol. 1993 May; 44(2):157-62. PMID: 7685037.
      View in: PubMed
    118. Hafler DA, Zhang JW, LaSalle J, Donnelly C, Weiner HL, Wucherpfeffnig K. The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis. Clin Exp Rheumatol. 1993 Mar-Apr; 11 Suppl 8:S39-40. PMID: 7686832.
      View in: PubMed
    119. LaSalle JM, Tolentino PJ, Freeman GJ, Nadler LM, Hafler DA. Early signaling defects in human T cells anergized by T cell presentation of autoantigen. J Exp Med. 1992 Jul 01; 176(1):177-86. PMID: 1535366.
      View in: PubMed
    120. LaSalle JM, Hafler DA. The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle. Cell Immunol. 1991 Nov; 138(1):197-206. PMID: 1833074.
      View in: PubMed
    121. LaSalle JM, Ota K, Hafler DA. Presentation of autoantigen by human T cells. J Immunol. 1991 Aug 01; 147(3):774-80. PMID: 1713605.
      View in: PubMed