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Gordon C Douglas

Title(s)Professor, Cell Biology and Human Anatomy
SchoolUniversity of California, Davis
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    Collapse Research 
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    Mechanisms of Rhesus Trophoblast Stem Cell Differentiation
    NIH/NICHD R01HD057114Mar 1, 2008 - Feb 28, 2013
    Role: Principal Investigator
    MACAQUE IN VITRO IMPLANTATION MODEL
    NIH/NICHD R03HD043863Jun 1, 2003 - May 31, 2006
    Role: Principal Investigator
    Flow Effects on Endothelial/Trophoblast Interaction
    NIH/NHLBI R01HL068035Jul 1, 2001 - May 31, 2014
    Role: Principal Investigator
    Flow Effects on Endothelial/Trophoblast Interaction
    NIH/NHLBI R56HL068035Jul 1, 2001 - May 31, 2009
    Role: Principal Investigator
    INTERACTION OF HIV WITH ISOLATED PLACENTAL CELLS
    NIH/NIAID R01AI032307Sep 30, 1991 - Jul 31, 1996
    Role: Principal Investigator
    FUNCTIONAL CYTOLOGY OF THE PLACENTA AND FETAL MEMBRANES
    NIH/NICHD R01HD011658Jul 1, 1978 - Mar 31, 2000
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kumar P, Thirkill TL, Ji J, Monte LH, Douglas GC. Differential Effects of Sodium Butyrate and Lithium Chloride on Rhesus Monkey Trophoblast Differentiation. PLoS One. 2015; 10(8):e0135089. PMID: 26266541.
      View in: PubMed
    2. Schroeder DI, Jayashankar K, Douglas KC, Thirkill TL, York D, Dickinson PJ, Williams LE, Samollow PB, Ross PJ, Bannasch DL, Douglas GC, LaSalle JM. Early Developmental and Evolutionary Origins of Gene Body DNA Methylation Patterns in Mammalian Placentas. PLoS Genet. 2015 Aug; 11(8):e1005442. PMID: 26241857.
      View in: PubMed
    3. Douglas GC, Thirkill TL, Kumar P, Loi M, Hilborn ED. Effect of microcystin-LR on human placental villous trophoblast differentiation in vitro. Environ Toxicol. 2016 Apr; 31(4):427-39. PMID: 25346179.
      View in: PubMed
    4. Kumar P, Ji J, Thirkill TL, Douglas GC. MUC1 Is Expressed by Human Skin Fibroblasts and Plays a Role in Cell Adhesion and Migration. Biores Open Access. 2014 Apr 01; 3(2):45-52. PMID: 24804164.
      View in: PubMed
    5. Kumar P, Kumar P, Lindberg L, Thirkill TL, Ji JW, Martsching L, Douglas GC. The MUC1 extracellular domain subunit is found in nuclear speckles and associates with spliceosomes. PLoS One. 2012; 7(8):e42712. PMID: 22905162.
      View in: PubMed
    6. Morgan JT, Pfeiffer ER, Thirkill TL, Kumar P, Peng G, Fridolfsson HN, Douglas GC, Starr DA, Barakat AI. Nesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarization. Mol Biol Cell. 2011 Nov; 22(22):4324-34. PMID: 21937718.
      View in: PubMed
    7. Douglas GC, VandeVoort CA, Kumar P, Chang TC, Golos TG. Trophoblast stem cells: models for investigating trophectoderm differentiation and placental development. Endocr Rev. 2009 May; 30(3):228-40. PMID: 19299251.
      View in: PubMed
    8. Cao TC, Thirkill TL, Wells M, Barakat AI, Douglas GC. Trophoblasts and shear stress induce an asymmetric distribution of icam-1 in uterine endothelial cells. Am J Reprod Immunol. 2008 Feb; 59(2):167-81. PMID: 18211542.
      View in: PubMed
    9. Vandevoort CA, Thirkill TL, Douglas GC. Blastocyst-derived trophoblast stem cells from the rhesus monkey. Stem Cells Dev. 2007 Oct; 16(5):779-88. PMID: 17999599.
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    10. Thirkill TL, Cao T, Stout M, Blankenship TN, Barakat A, Douglas GC. MUC1 is involved in trophoblast transendothelial migration. Biochim Biophys Acta. 2007 Jun; 1773(6):1007-14. PMID: 17509701.
      View in: PubMed
    11. Gautam M, Shen Y, Thirkill TL, Douglas GC, Barakat AI. Flow-activated chloride channels in vascular endothelium. Shear stress sensitivity, desensitization dynamics, and physiological implications. J Biol Chem. 2006 Dec 01; 281(48):36492-500. PMID: 16973617.
      View in: PubMed
    12. Thirkill TL, Vedagiri H, Douglas GC. Macaque trophoblast migration toward RANTES is inhibited by cigarette smoke-conditioned medium. Toxicol Sci. 2006 Jun; 91(2):557-67. PMID: 16514183.
      View in: PubMed
    13. Zhong CY, Zhou YM, Douglas GC, Witschi H, Pinkerton KE. MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of rats. Carcinogenesis. 2005 Dec; 26(12):2187-95. PMID: 16051644.
      View in: PubMed
    14. Enders AC, Meyers S, Vandevoort CA, Douglas GC. Interactions of macaque blastocysts with epithelial cells in vitro. Hum Reprod. 2005 Nov; 20(11):3026-32. PMID: 16006466.
      View in: PubMed
    15. Thirkill TL, Lowe K, Vedagiri H, Blankenship TN, Barakat AI, Douglas GC. Macaque trophoblast migration is regulated by RANTES. Exp Cell Res. 2005 May 01; 305(2):355-64. PMID: 15817160.
      View in: PubMed
    16. Soghomonians A, Barakat AI, Thirkill TL, Douglas GC. Trophoblast migration under flow is regulated by endothelial cells. Biol Reprod. 2005 Jul; 73(1):14-9. PMID: 15744025.
      View in: PubMed
    17. Soghomonians A, Thirkill TL, Mariano NF, Barakat AI, Douglas GC. Effect of aqueous tobacco smoke extract and shear stress on PECAM-1 expression and cell motility in human uterine endothelial cells. Toxicol Sci. 2004 Oct; 81(2):408-18. PMID: 15240893.
      View in: PubMed
    18. Thirkill TL, Hendren SR, Soghomonians A, Mariano NF, Barakat AI, Douglas GC. Regulation of trophoblast beta1-integrin expression by contact with endothelial cells. Cell Commun Signal. 2004 Jun 09; 2(1):4. PMID: 15189562.
      View in: PubMed
    19. Chen J, Thirkill TL, Lohstroh PN, Bielmeier SR, Narotsky MG, Best DS, Harrison RA, Natarajan K, Pegram RA, Overstreet JW, Lasley BL, Douglas GC. Bromodichloromethane inhibits human placental trophoblast differentiation. Toxicol Sci. 2004 Mar; 78(1):166-74. PMID: 14691210.
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    20. Chen J, Douglas GC, Thirkill TL, Lohstroh PN, Bielmeier SR, Narotsky MG, Best DS, Harrison RA, Natarajan K, Pegram RA, Overstreet JW, Lasley BL. Effect of bromodichloromethane on chorionic gonadotrophin secretion by human placental trophoblast cultures. Toxicol Sci. 2003 Nov; 76(1):75-82. PMID: 12970577.
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    21. Chen J, Thirkill TL, Overstreet JW, Lasley BL, Douglas GC. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on chorionic gonadotropin secretion by human trophoblasts. Reprod Toxicol. 2003 Jan-Feb; 17(1):87-93. PMID: 12507663.
      View in: PubMed
    22. Himathongkham S, Douglas GC, Fang A, Yu E, Barnett SW, Luciw PA. Species tropism of chimeric SHIV clones containing HIV-1 subtype-A and subtype-E envelope genes. Virology. 2002 Jul 05; 298(2):189-99. PMID: 12127782.
      View in: PubMed
    23. Soghomonians A, Barakat AI, Thirkill TL, Blankenship TN, Douglas GC. Effect of shear stress on migration and integrin expression in macaque trophoblast cells. Biochim Biophys Acta. 2002 May 08; 1589(3):233-46. PMID: 12031791.
      View in: PubMed
    24. Douglas GC, Thirkill TL, LaSalle J. Automated quantitation of cell-mediated HIV type 1 infection of human syncytiotrophoblast cells by fluorescence in situ hybridization and laser scanning cytometry. AIDS Res Hum Retroviruses. 2001 Apr 10; 17(6):507-16. PMID: 11350664.
      View in: PubMed
    25. Douglas GC, Thirkill TL. Chemokine receptor expression by human syncytiotrophoblast--a review. Placenta. 2001 Apr; 22 Suppl A:S24-8. PMID: 11312624.
      View in: PubMed
    26. Anderson V, Carneiro M, Bulterys M, Douglas G, Polliotti B, Slikker W. Perinatal infections: HIV and co-infections in the placenta and therapeutic interventions-a workshop report. Placenta. 2001 Apr; 22 Suppl A:S34-7. PMID: 11312626.
      View in: PubMed
    27. Douglas GC, Thirkill TL, Sideris V, Rabieh M, Trollinger D, Nuccitelli R. Chemokine receptor expression by human syncytiotrophoblast. J Reprod Immunol. 2001 Feb; 49(2):97-114. PMID: 11164896.
      View in: PubMed
    28. Douglas GC, Thirkill TL, Blankenship TN. Vitronectin receptors are expressed by macaque trophoblast cells and play a role in migration and adhesion to endothelium. Biochim Biophys Acta. 1999 Oct 13; 1452(1):36-45. PMID: 10525158.
      View in: PubMed
    29. Thirkill TL, Douglas GC. The vitronectin receptor plays a role in the adhesion of human cytotrophoblast cells to endothelial cells. Endothelium. 1999; 6(4):277-90. PMID: 10475091.
      View in: PubMed
    30. Davidson JB, Douglas GC. Modulation of integrin function inhibits HIV transmission to epithelial cells and fertilization. J Reprod Immunol. 1998 Dec; 41(1-2):271-90. PMID: 10213316.
      View in: PubMed
    31. Douglas GC, Fazely F, Hu JJ. Transmission of HIV to the placenta, fetus and mother and implications of gametic infection. J Reprod Immunol. 1998 Dec; 41(1-2):321-9. PMID: 10213320.
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    32. Douglas GC, Moreira-Cali P, King BF, Lonnerdal B. Uptake of 125I-labelled alpha2-macroglobulin and albumin by human placental syncytiotrophoblast in vitro. J Cell Biochem. 1998 Mar 15; 68(4):427-35. PMID: 9493906.
      View in: PubMed
    33. Ho HH, Douglas GC, Qiu QF, Thirkill TL, Overstreet JW, Lasley BL. The relationship between trophoblast differentiation and the production of bioactive hCG. Early Pregnancy. 1997 Dec; 3(4):291-300. PMID: 10086080.
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    34. Thirkill TL, Douglas GC. Differentiation of human trophoblast cells in vitro is inhibited by dimethylsulfoxide. J Cell Biochem. 1997 Jun 15; 65(4):460-8. PMID: 9178096.
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    35. Kennedy ML, Douglas GC, King BF. Effect of iron on transferrin receptor expression by human placental syncytiotrophoblast cells. Reprod Fertil Dev. 1997; 9(6):609-16. PMID: 9551665.
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    36. Fazeley F, Hu J, Thirkill TL, Douglas GC. Infection of primary human placental fibroblasts with HIV-1, HIV-2, and SIV. Arch Virol. 1997; 142(11):2237-48. PMID: 9672589.
      View in: PubMed
    37. Fazely F, Fry GN, Thirkill TL, Hakim H, King BF, Douglas GC. Kinetics of HIV infection of human placental syncytiotrophoblast cultures: an ultrastructural and immunocytochemical study. AIDS Res Hum Retroviruses. 1995 Sep; 11(9):1023-30. PMID: 8554899.
      View in: PubMed
    38. Gíslason J, Douglas GC, Hutchens TW, Lönnerdal B. Receptor-mediated binding of milk lactoferrin to nursing piglet enterocytes: a model for studies on absorption of lactoferrin-bound iron. J Pediatr Gastroenterol Nutr. 1995 Jul; 21(1):37-43. PMID: 8576812.
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    39. Douglas GC, Hu J, Thirkill TL, Hovanes K, Fuller M, King BF. Cyclohexylamine inhibits the adhesion of lymphocytic cells to human syncytiotrophoblast. Biochim Biophys Acta. 1995 May 12; 1266(3):229-34. PMID: 7766708.
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    40. Milio LA, Hu J, Douglas GC. Binding of insulin-like growth factor I to human trophoblast cells during differentiation in vitro. Placenta. 1994 Sep; 15(6):641-51. PMID: 7824449.
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    41. Douglas GC, Hu J, Thirkill TL, Hovanes K, Sharma S, King BF. Effect of cytokines and anti-adhesion molecule antibodies on the adhesion of lymphocytic cells to human syncytiotrophoblast. J Reprod Immunol. 1994 Aug; 27(1):49-62. PMID: 7807471.
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    42. Gíslason J, Iyer S, Douglas GC, Hutchens TW, Lönnerdal B. Binding of porcine milk lactoferrin to piglet intestinal lactoferrin receptor. Adv Exp Med Biol. 1994; 357:239-44. PMID: 7762438.
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    43. Douglas GC, Sloan CL, Hovanes K, Thirkill TL, Fry GN, Hakim H, Schmerl S, Jennings M, King BF. Adhesion of lymphocytic cells to human trophoblast cells in vitro. J Reprod Immunol. 1993 May; 24(1):65-80. PMID: 8102403.
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    44. Douglas GC, King BF. Colchicine inhibits human trophoblast differentiation in vitro. Placenta. 1993 Mar-Apr; 14(2):187-201. PMID: 8506250.
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    45. Douglas GC, King BF. Maternal-fetal transmission of human immunodeficiency virus: a review of possible routes and cellular mechanisms of infection. Clin Infect Dis. 1992 Oct; 15(4):678-91. PMID: 1420681.
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    46. Kennedy ML, Douglas GC, King BF. Expression of transferrin receptors during differentiation of human placental trophoblast cells in vitro. Placenta. 1992 Jan-Feb; 13(1):43-53. PMID: 1502136.
      View in: PubMed
    47. Douglas GC, Fry GN, Thirkill T, Holmes E, Hakim H, Jennings M, King BF. Cell-mediated infection of human placental trophoblast with HIV in vitro. AIDS Res Hum Retroviruses. 1991 Sep; 7(9):735-40. PMID: 1742080.
      View in: PubMed
    48. Kennedy ML, Douglas GC, King BF, Lonnerdal B. Interaction of 125I-labelled ceruloplasmin with human trophoblast cells in vitro. Placenta. 1990 Nov-Dec; 11(6):523-33. PMID: 2290803.
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    49. Douglas GC, King BF. Isolation and morphologic differentiation in vitro of villous cytotrophoblast cells from rhesus monkey placenta. In Vitro Cell Dev Biol. 1990 Aug; 26(8):754-8. PMID: 2394671.
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    50. Douglas GC, King BF. Differentiation of human trophoblast cells in vitro as revealed by immunocytochemical staining of desmoplakin and nuclei. J Cell Sci. 1990 May; 96 ( Pt 1):131-41. PMID: 2165075.
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    51. Douglas GC, King BF. Uptake and processing of 125I-labelled transferrin and 59Fe-labelled transferrin by isolated human trophoblast cells. Placenta. 1990 Jan-Feb; 11(1):41-57. PMID: 2326236.
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    52. Douglas GC, King BF. Isolation of pure villous cytotrophoblast from term human placenta using immunomagnetic microspheres. J Immunol Methods. 1989 May 12; 119(2):259-68. PMID: 2470826.
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    53. Douglas GC, King BF. Effects of monensin on the receptor-mediated endocytosis of 125I-labelled IgG by guinea-pig yolk sac in vitro. Placenta. 1988 May-Jun; 9(3):277-88. PMID: 2971938.
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    54. Douglas GC, King BF. Receptor-mediated endocytosis of 125I-labelled transferrin by human choriocarcinoma (JAR) cells. Placenta. 1988 May-Jun; 9(3):253-65. PMID: 3174602.
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    55. Douglas GC, Judah JD, Ellis RB, King BF, Mackenzie A. Secretion and biosynthesis of N-acetyl-beta-D-hexosaminidases by human placental tissues in vitro. Placenta. 1985 May-Jun; 6(3):239-47. PMID: 3161018.
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    56. Douglas GC, King BF. Endocytosis and subsequent processing of 125I-labelled immunoglobulin G by guinea pig yolk sac in vitro. Biochem J. 1985 Apr 15; 227(2):639-50. PMID: 4004783.
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    57. Douglas GC, King BF. A filter paper sandwich method using small volumes of reagents for the detection of antigens electrophoretically transferred onto nitrocellulose. J Immunol Methods. 1984 Dec 31; 75(2):333-8. PMID: 6097613.
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    58. Douglas GC. Lysosomal enzyme secretion from human placental villi is increased by serum albumin and IgG. Exp Cell Biol. 1981; 49(5):233-8. PMID: 6456954.
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    59. Douglas GC, Mackenzie A. Secretion of lysosomal enzymes by human placental villi in vitro. Mol Cell Biochem. 1980 Dec 10; 33(1-2):93-6. PMID: 6451798.
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    60. Douglas GC, Mackenzie A. Partial isolation and translation in vitro of mRNA species coding for alpha- and beta-subunits of human placental N-acetyl-beta-D-hexosaminidase. Biochem Soc Trans. 1978; 6(5):1072-9. PMID: 744325.
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