Gordon C Douglas

Title(s)Professor, Cell Biology and Human Anatomy
SchoolSchool of Medicine
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    Mechanisms of Rhesus Trophoblast Stem Cell Differentiation
    NIH/NICHD R01HD057114Mar 1, 2008 - Feb 28, 2013
    Role: Principal Investigator
    NIH/NICHD R03HD043863Jun 1, 2003 - May 31, 2006
    Role: Principal Investigator
    Flow Effects on Endothelial/Trophoblast Interaction
    NIH/NHLBI R01HL068035Jul 1, 2001 - May 31, 2014
    Role: Principal Investigator
    Flow Effects on Endothelial/Trophoblast Interaction
    NIH/NHLBI R56HL068035Jul 1, 2001 - May 31, 2009
    Role: Principal Investigator
    NIH/NIAID R01AI032307Sep 30, 1991 - Jul 31, 1996
    Role: Principal Investigator
    NIH/NICHD R01HD011658Jul 1, 1978 - Mar 31, 2000
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Differential Effects of Sodium Butyrate and Lithium Chloride on Rhesus Monkey Trophoblast Differentiation. PLoS One. 2015; 10(8):e0135089. Kumar P, Thirkill TL, Ji J, Monte LH, Douglas GC. PMID: 26266541; PMCID: PMC4533975.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    2. Early Developmental and Evolutionary Origins of Gene Body DNA Methylation Patterns in Mammalian Placentas. PLoS Genet. 2015 Aug; 11(8):e1005442. Schroeder DI, Jayashankar K, Douglas KC, Thirkill TL, York D, Dickinson PJ, Williams LE, Samollow PB, Ross PJ, Bannasch DL, Douglas GC, LaSalle JM. PMID: 26241857; PMCID: PMC4524645.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    3. Effect of microcystin-LR on human placental villous trophoblast differentiation in vitro. Environ Toxicol. 2016 Apr; 31(4):427-39. Douglas GC, Thirkill TL, Kumar P, Loi M, Hilborn ED. PMID: 25346179.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. MUC1 Is Expressed by Human Skin Fibroblasts and Plays a Role in Cell Adhesion and Migration. Biores Open Access. 2014 Apr 01; 3(2):45-52. Kumar P, Ji J, Thirkill TL, Douglas GC. PMID: 24804164; PMCID: PMC3995082.
      View in: PubMed   Mentions: 6  
    5. The MUC1 extracellular domain subunit is found in nuclear speckles and associates with spliceosomes. PLoS One. 2012; 7(8):e42712. Kumar P, Kumar P, Lindberg L, Thirkill TL, Ji JW, Martsching L, Douglas GC. PMID: 22905162; PMCID: PMC3414450.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    6. Nesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarization. Mol Biol Cell. 2011 Nov; 22(22):4324-34. Morgan JT, Pfeiffer ER, Thirkill TL, Kumar P, Peng G, Fridolfsson HN, Douglas GC, Starr DA, Barakat AI. PMID: 21937718; PMCID: PMC3216658.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    7. Trophoblast stem cells: models for investigating trophectoderm differentiation and placental development. Endocr Rev. 2009 May; 30(3):228-40. Douglas GC, VandeVoort CA, Kumar P, Chang TC, Golos TG. PMID: 19299251; PMCID: PMC2726840.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    8. Trophoblasts and shear stress induce an asymmetric distribution of icam-1 in uterine endothelial cells. Am J Reprod Immunol. 2008 Feb; 59(2):167-81. Cao TC, Thirkill TL, Wells M, Barakat AI, Douglas GC. PMID: 18211542.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Blastocyst-derived trophoblast stem cells from the rhesus monkey. Stem Cells Dev. 2007 Oct; 16(5):779-88. Vandevoort CA, Thirkill TL, Douglas GC. PMID: 17999599.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    10. MUC1 is involved in trophoblast transendothelial migration. Biochim Biophys Acta. 2007 Jun; 1773(6):1007-14. Thirkill TL, Cao T, Stout M, Blankenship TN, Barakat A, Douglas GC. PMID: 17509701; PMCID: PMC1986703.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    11. Flow-activated chloride channels in vascular endothelium. Shear stress sensitivity, desensitization dynamics, and physiological implications. J Biol Chem. 2006 Dec 01; 281(48):36492-500. Gautam M, Shen Y, Thirkill TL, Douglas GC, Barakat AI. PMID: 16973617.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    12. Macaque trophoblast migration toward RANTES is inhibited by cigarette smoke-conditioned medium. Toxicol Sci. 2006 Jun; 91(2):557-67. Thirkill TL, Vedagiri H, Douglas GC. PMID: 16514183.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    13. MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of rats. Carcinogenesis. 2005 Dec; 26(12):2187-95. Zhong CY, Zhou YM, Douglas GC, Witschi H, Pinkerton KE. PMID: 16051644.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    14. Interactions of macaque blastocysts with epithelial cells in vitro. Hum Reprod. 2005 Nov; 20(11):3026-32. Enders AC, Meyers S, Vandevoort CA, Douglas GC. PMID: 16006466.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    15. Macaque trophoblast migration is regulated by RANTES. Exp Cell Res. 2005 May 01; 305(2):355-64. Thirkill TL, Lowe K, Vedagiri H, Blankenship TN, Barakat AI, Douglas GC. PMID: 15817160.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. Trophoblast migration under flow is regulated by endothelial cells. Biol Reprod. 2005 Jul; 73(1):14-9. Soghomonians A, Barakat AI, Thirkill TL, Douglas GC. PMID: 15744025.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    17. Effect of aqueous tobacco smoke extract and shear stress on PECAM-1 expression and cell motility in human uterine endothelial cells. Toxicol Sci. 2004 Oct; 81(2):408-18. Soghomonians A, Thirkill TL, Mariano NF, Barakat AI, Douglas GC. PMID: 15240893.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. Regulation of trophoblast beta1-integrin expression by contact with endothelial cells. Cell Commun Signal. 2004 Jun 09; 2(1):4. Thirkill TL, Hendren SR, Soghomonians A, Mariano NF, Barakat AI, Douglas GC. PMID: 15189562; PMCID: PMC434534.
      View in: PubMed   Mentions: 4     Fields:    
    19. Bromodichloromethane inhibits human placental trophoblast differentiation. Toxicol Sci. 2004 Mar; 78(1):166-74. Chen J, Thirkill TL, Lohstroh PN, Bielmeier SR, Narotsky MG, Best DS, Harrison RA, Natarajan K, Pegram RA, Overstreet JW, Lasley BL, Douglas GC. PMID: 14691210.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    20. Effect of bromodichloromethane on chorionic gonadotrophin secretion by human placental trophoblast cultures. Toxicol Sci. 2003 Nov; 76(1):75-82. Chen J, Douglas GC, Thirkill TL, Lohstroh PN, Bielmeier SR, Narotsky MG, Best DS, Harrison RA, Natarajan K, Pegram RA, Overstreet JW, Lasley BL. PMID: 12970577.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on chorionic gonadotropin secretion by human trophoblasts. Reprod Toxicol. 2003 Jan-Feb; 17(1):87-93. Chen J, Thirkill TL, Overstreet JW, Lasley BL, Douglas GC. PMID: 12507663.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    22. Species tropism of chimeric SHIV clones containing HIV-1 subtype-A and subtype-E envelope genes. Virology. 2002 Jul 05; 298(2):189-99. Himathongkham S, Douglas GC, Fang A, Yu E, Barnett SW, Luciw PA. PMID: 12127782.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    23. Effect of shear stress on migration and integrin expression in macaque trophoblast cells. Biochim Biophys Acta. 2002 May 08; 1589(3):233-46. Soghomonians A, Barakat AI, Thirkill TL, Blankenship TN, Douglas GC. PMID: 12031791.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    24. Automated quantitation of cell-mediated HIV type 1 infection of human syncytiotrophoblast cells by fluorescence in situ hybridization and laser scanning cytometry. AIDS Res Hum Retroviruses. 2001 Apr 10; 17(6):507-16. Douglas GC, Thirkill TL, LaSalle J. PMID: 11350664.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    25. Chemokine receptor expression by human syncytiotrophoblast--a review. Placenta. 2001 Apr; 22 Suppl A:S24-8. Douglas GC, Thirkill TL. PMID: 11312624.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    26. Perinatal infections: HIV and co-infections in the placenta and therapeutic interventions-a workshop report. Placenta. 2001 Apr; 22 Suppl A:S34-7. Anderson V, Carneiro M, Bulterys M, Douglas G, Polliotti B, Slikker W. PMID: 11312626.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    27. Chemokine receptor expression by human syncytiotrophoblast. J Reprod Immunol. 2001 Feb; 49(2):97-114. Douglas GC, Thirkill TL, Sideris V, Rabieh M, Trollinger D, Nuccitelli R. PMID: 11164896.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    28. Vitronectin receptors are expressed by macaque trophoblast cells and play a role in migration and adhesion to endothelium. Biochim Biophys Acta. 1999 Oct 13; 1452(1):36-45. Douglas GC, Thirkill TL, Blankenship TN. PMID: 10525158.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    29. The vitronectin receptor plays a role in the adhesion of human cytotrophoblast cells to endothelial cells. Endothelium. 1999; 6(4):277-90. Thirkill TL, Douglas GC. PMID: 10475091.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    30. Modulation of integrin function inhibits HIV transmission to epithelial cells and fertilization. J Reprod Immunol. 1998 Dec; 41(1-2):271-90. Davidson JB, Douglas GC. PMID: 10213316.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Transmission of HIV to the placenta, fetus and mother and implications of gametic infection. J Reprod Immunol. 1998 Dec; 41(1-2):321-9. Douglas GC, Fazely F, Hu JJ. PMID: 10213320.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    32. Uptake of 125I-labelled alpha2-macroglobulin and albumin by human placental syncytiotrophoblast in vitro. J Cell Biochem. 1998 Mar 15; 68(4):427-35. Douglas GC, Moreira-Cali P, King BF, Lonnerdal B. PMID: 9493906.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    33. The relationship between trophoblast differentiation and the production of bioactive hCG. Early Pregnancy. 1997 Dec; 3(4):291-300. Ho HH, Douglas GC, Qiu QF, Thirkill TL, Overstreet JW, Lasley BL. PMID: 10086080.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    34. Differentiation of human trophoblast cells in vitro is inhibited by dimethylsulfoxide. J Cell Biochem. 1997 Jun 15; 65(4):460-8. Thirkill TL, Douglas GC. PMID: 9178096.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    35. Effect of iron on transferrin receptor expression by human placental syncytiotrophoblast cells. Reprod Fertil Dev. 1997; 9(6):609-16. Kennedy ML, Douglas GC, King BF. PMID: 9551665.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    36. Infection of primary human placental fibroblasts with HIV-1, HIV-2, and SIV. Arch Virol. 1997; 142(11):2237-48. Fazeley F, Hu J, Thirkill TL, Douglas GC. PMID: 9672589.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    37. Kinetics of HIV infection of human placental syncytiotrophoblast cultures: an ultrastructural and immunocytochemical study. AIDS Res Hum Retroviruses. 1995 Sep; 11(9):1023-30. Fazely F, Fry GN, Thirkill TL, Hakim H, King BF, Douglas GC. PMID: 8554899.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    38. Receptor-mediated binding of milk lactoferrin to nursing piglet enterocytes: a model for studies on absorption of lactoferrin-bound iron. J Pediatr Gastroenterol Nutr. 1995 Jul; 21(1):37-43. Gíslason J, Douglas GC, Hutchens TW, Lönnerdal B. PMID: 8576812.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    39. Cyclohexylamine inhibits the adhesion of lymphocytic cells to human syncytiotrophoblast. Biochim Biophys Acta. 1995 May 12; 1266(3):229-34. Douglas GC, Hu J, Thirkill TL, Hovanes K, Fuller M, King BF. PMID: 7766708.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    40. Binding of insulin-like growth factor I to human trophoblast cells during differentiation in vitro. Placenta. 1994 Sep; 15(6):641-51. Milio LA, Hu J, Douglas GC. PMID: 7824449.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    41. Effect of cytokines and anti-adhesion molecule antibodies on the adhesion of lymphocytic cells to human syncytiotrophoblast. J Reprod Immunol. 1994 Aug; 27(1):49-62. Douglas GC, Hu J, Thirkill TL, Hovanes K, Sharma S, King BF. PMID: 7807471.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    42. Isolated trophoblast cells for studies of placental infection: Advantages and precautions. Placenta. 1994 Jan 1; 15:247-250. Douglas DG, King KB. .
      View in: Publisher Site   Mentions:
    43. Binding of porcine milk lactoferrin to piglet intestinal lactoferrin receptor. Adv Exp Med Biol. 1994; 357:239-44. Gíslason J, Iyer S, Douglas GC, Hutchens TW, Lönnerdal B. PMID: 7762438.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    44. Adhesion of lymphocytic cells to human trophoblast cells in vitro. J Reprod Immunol. 1993 May; 24(1):65-80. Douglas GC, Sloan CL, Hovanes K, Thirkill TL, Fry GN, Hakim H, Schmerl S, Jennings M, King BF. PMID: 8102403.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    45. Colchicine inhibits human trophoblast differentiation in vitro. Placenta. 1993 Mar-Apr; 14(2):187-201. Douglas GC, King BF. PMID: 8506250.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    46. Maternal-fetal transmission of human immunodeficiency virus: a review of possible routes and cellular mechanisms of infection. Clin Infect Dis. 1992 Oct; 15(4):678-91. Douglas GC, King BF. PMID: 1420681.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    47. Expression of transferrin receptors during differentiation of human placental trophoblast cells in vitro. Placenta. 1992 Jan-Feb; 13(1):43-53. Kennedy ML, Douglas GC, King BF. PMID: 1502136.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    48. Cell-mediated infection of human placental trophoblast with HIV in vitro. AIDS Res Hum Retroviruses. 1991 Sep; 7(9):735-40. Douglas GC, Fry GN, Thirkill T, Holmes E, Hakim H, Jennings M, King BF. PMID: 1742080.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    49. Interaction of 125I-labelled ceruloplasmin with human trophoblast cells in vitro. Placenta. 1990 Nov-Dec; 11(6):523-33. Kennedy ML, Douglas GC, King BF, Lonnerdal B. PMID: 2290803.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    50. Isolation and morphologic differentiation in vitro of villous cytotrophoblast cells from rhesus monkey placenta. In Vitro Cell Dev Biol. 1990 Aug; 26(8):754-8. Douglas GC, King BF. PMID: 2394671.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    51. Differentiation of human trophoblast cells in vitro as revealed by immunocytochemical staining of desmoplakin and nuclei. J Cell Sci. 1990 May; 96 ( Pt 1):131-41. Douglas GC, King BF. PMID: 2165075.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    52. Uptake and processing of 125I-labelled transferrin and 59Fe-labelled transferrin by isolated human trophoblast cells. Placenta. 1990 Jan-Feb; 11(1):41-57. Douglas GC, King BF. PMID: 2326236.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    53. Isolation of pure villous cytotrophoblast from term human placenta using immunomagnetic microspheres. J Immunol Methods. 1989 May 12; 119(2):259-68. Douglas GC, King BF. PMID: 2470826.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    54. Effects of monensin on the receptor-mediated endocytosis of 125I-labelled IgG by guinea-pig yolk sac in vitro. Placenta. 1988 May-Jun; 9(3):277-88. Douglas GC, King BF. PMID: 2971938.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    55. Receptor-mediated endocytosis of 125I-labelled transferrin by human choriocarcinoma (JAR) cells. Placenta. 1988 May-Jun; 9(3):253-65. Douglas GC, King BF. PMID: 3174602.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    56. Secretion and biosynthesis of N-acetyl-beta-D-hexosaminidases by human placental tissues in vitro. Placenta. 1985 May-Jun; 6(3):239-47. Douglas GC, Judah JD, Ellis RB, King BF, Mackenzie A. PMID: 3161018.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    57. Endocytosis and subsequent processing of 125I-labelled immunoglobulin G by guinea pig yolk sac in vitro. Biochem J. 1985 Apr 15; 227(2):639-50. Douglas GC, King BF. PMID: 4004783; PMCID: PMC1144884.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    58. A filter paper sandwich method using small volumes of reagents for the detection of antigens electrophoretically transferred onto nitrocellulose. J Immunol Methods. 1984 Dec 31; 75(2):333-8. Douglas GC, King BF. PMID: 6097613.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    59. Lysosomal enzyme secretion from human placental villi is increased by serum albumin and IgG. Exp Cell Biol. 1981; 49(5):233-8. Douglas GC. PMID: 6456954.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    60. Secretion of lysosomal enzymes by human placental villi in vitro. Mol Cell Biochem. 1980 Dec 10; 33(1-2):93-6. Douglas GC, Mackenzie A. PMID: 6451798.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    61. Partial isolation and translation in vitro of mRNA species coding for alpha- and beta-subunits of human placental N-acetyl-beta-D-hexosaminidase. Biochem Soc Trans. 1978; 6(5):1072-9. Douglas GC, Mackenzie A. PMID: 744325.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
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