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Carl L Keen

Title(s)Professor, NUTRITION
SchoolUniversity of California, Davis
Phone530-752-6331
Emailclkeen@ucdavis.edu
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Al-Dashti YA, Holt RR, Carson JG, Keen CL, Hackman RM. Effects of Short-Term Dried Plum (Prune) Intake on Markers of Bone Resorption and Vascular Function in Healthy Postmenopausal Women: A Randomized Crossover Trial. J Med Food. 2019 Oct; 22(10):982-992. PMID: 31194598.
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    2. Borkowski K, Yim SJ, Holt RR, Hackman RM, Keen CL, Newman JW, Shearer GC. Walnuts change lipoprotein composition suppressing TNFa-stimulated cytokine production by diabetic adipocyte. J Nutr Biochem. 2019 Jun; 68:51-58. PMID: 31030167.
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    3. Scherr RE, Linnell JD, Dharmar M, Beccarelli LM, Bergman JJ, Briggs M, Brian KM, Feenstra G, Hillhouse JC, Keen CL, Schaefer SE, Smith MH, Spezzano T, Steinberg FM, Young HM, Zidenberg-Cherr S. Response to "Dramatic Decreases in BMI Percentiles, but Valid Conclusions Can Only Come From Valid Analyses". J Nutr Educ Behav. 2018 09; 50(8):851. PMID: 30077580.
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    4. Al-Dashti YA, Holt RR, Stebbins CL, Keen CL, Hackman RM. Dietary Flavanols: A Review of Select Effects on Vascular Function, Blood Pressure, and Exercise Performance. J Am Coll Nutr. 2018 Sep-Oct; 37(7):553-567. PMID: 29718795.
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    5. Scherr RE, Linnell JD, Dharmar M, Beccarelli LM, Bergman JJ, Briggs M, Brian KM, Feenstra G, Hillhouse JC, Keen CL, Ontai LL, Schaefer SE, Smith MH, Spezzano T, Steinberg FM, Sutter C, Young HM, Zidenberg-Cherr S. Response to "A Comment on Scherr et al 'A Multicomponent, School-Based Intervention, the Shaping Healthy Choices Program, Improves Nutrition-Related Outcomes'". J Nutr Educ Behav. 2018 03; 50(3):326-327. PMID: 29524985.
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    6. Beccarelli LM, Scherr RE, Newman JW, Borkowska AG, Gray IJ, Linnell JD, Keen CL, Young HM. Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children. J Am Coll Nutr. 2018 01; 37(1):44-50. PMID: 29043930.
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    7. Scherr RE, Linnell JD, Dharmar M, Beccarelli LM, Bergman JJ, Briggs M, Brian KM, Feenstra G, Hillhouse JC, Keen CL, Ontai LL, Schaefer SE, Smith MH, Spezzano T, Steinberg FM, Sutter C, Young HM, Zidenberg-Cherr S. A Multicomponent, School-Based Intervention, the Shaping Healthy Choices Program, Improves Nutrition-Related Outcomes. J Nutr Educ Behav. 2017 05; 49(5):368-379.e1. PMID: 28189500.
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    8. Carlson CR, Uriu-Adams JY, Chambers CD, Yevtushok L, Zymak-Zakutnya N, Chan PH, Schafer JJ, Wertelecki W, Keen CL. Vitamin D Deficiency in Pregnant Ukrainian Women: Effects of Alcohol Consumption on Vitamin D Status. J Am Coll Nutr. 2017 01; 36(1):44-56. PMID: 28169608.
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    9. Borchers AT, Keen CL, Gershwin ME. The Basis of Structure/Function Claims of Nutraceuticals. Clin Rev Allergy Immunol. 2016 Dec; 51(3):370-382. PMID: 27122022.
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    10. Beccarelli LM, Scherr RE, Dharmar M, Ermakov IV, Gellermann W, Jahns L, Linnell JD, Keen CL, Steinberg FM, Young HM, Zidenberg-Cherr S. Using Skin Carotenoids to Assess Dietary Changes in Students After 1 Academic Year of Participating in the Shaping Healthy Choices Program. J Nutr Educ Behav. 2017 01; 49(1):73-78.e1. PMID: 28341018.
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    11. Medici V, Kieffer DA, Shibata NM, Chima H, Kim K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda KK, Olson K, Su RJ, Islam MS, Syed R, Keen CL, Miller AY, Rutledge JC, Halsted CH, LaSalle JM. Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model. Epigenetics. 2016 Nov; 11(11):804-818. PMID: 27611852.
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    12. Djurica D, Holt RR, Ren J, Shindel AW, Hackman RM, Keen CL. Effects of a dietary strawberry powder on parameters of vascular health in adolescent males. Br J Nutr. 2016 Aug; 116(4):639-47. PMID: 27464461.
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    13. Ottaviani JI, Borges G, Momma TY, Spencer JP, Keen CL, Crozier A, Schroeter H. The metabolome of [2-(14)C](-)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives. Sci Rep. 2016 07 01; 6:29034. PMID: 27363516.
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    14. Hourigan LA, Omaye ST, Keen CL, Jones JA, Dubick MA. Vitamin and Trace Element Loss from Negative-Pressure Wound Therapy. Adv Skin Wound Care. 2016 Jan; 29(1):20-25. PMID: 26650093.
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    15. Coles CD, Kable JA, Keen CL, Jones KL, Wertelecki W, Granovska IV, Pashtepa AO, Chambers CD. Dose and Timing of Prenatal Alcohol Exposure and Maternal Nutritional Supplements: Developmental Effects on 6-Month-Old Infants. Matern Child Health J. 2015 Dec; 19(12):2605-14. PMID: 26164422.
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    16. Sowell KD, Keen CL, Uriu-Adams JY. Vitamin D and Reproduction: From Gametes to Childhood. Healthcare (Basel). 2015 Nov 09; 3(4):1097-120. PMID: 27417816.
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    17. Ottaviani JI, Balz M, Kimball J, Ensunsa JL, Fong R, Momma TY, Kwik-Uribe C, Schroeter H, Keen CL. Safety and efficacy of cocoa flavanol intake in healthy adults: a randomized, controlled, double-masked trial. Am J Clin Nutr. 2015 Dec; 102(6):1425-35. PMID: 26537937.
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    18. Schroeter H, Keen CL, Sesso HD, Manson JE, Lupton JR. Is this the end of (-)-epicatechin, or not? New study highlights the complex challenges associated with research into the cardiovascular health benefits of bioactive food constituents. Am J Clin Nutr. 2015 Oct; 102(4):975-6. PMID: 26429943.
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    19. Holt RR, Yim SJ, Shearer GC, Hackman RM, Djurica D, Newman JW, Shindel AW, Keen CL. Effects of short-term walnut consumption on human microvascular function and its relationship to plasma epoxide content. J Nutr Biochem. 2015 Dec; 26(12):1458-66. PMID: 26396054.
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    20. Nguyen LM, Scherr RE, Linnell JD, Ermakov IV, Gellermann W, Jahns L, Keen CL, Miyamoto S, Steinberg FM, Young HM, Zidenberg-Cherr S. Evaluating the relationship between plasma and skin carotenoids and reported dietary intake in elementary school children to assess fruit and vegetable intake. Arch Biochem Biophys. 2015 Apr 15; 572:73-80. PMID: 25765187.
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    21. Dubick MA, Barr JL, Keen CL, Atkins JL. Ceruloplasmin and Hypoferremia: Studies in Burn and Non-Burn Trauma Patients. Antioxidants (Basel). 2015 Mar 06; 4(1):153-69. PMID: 26785343.
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    22. Yang H, Keen CL, Lanoue L. Influence of intracellular zinc on cultures of rat cardiac neural crest cells. Birth Defects Res B Dev Reprod Toxicol. 2015 Feb; 104(1):11-22. PMID: 25689142.
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    23. Dwyer JT, Wiemer KL, Dary O, Keen CL, King JC, Miller KB, Philbert MA, Tarasuk V, Taylor CL, Gaine PC, Jarvis AB, Bailey RL. Fortification and health: challenges and opportunities. Adv Nutr. 2015 Jan; 6(1):124-31. PMID: 25593151.
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    24. Lesser MNR, Keen CL, Lanoue L. Reproductive and developmental outcomes, and influence on maternal and offspring tissue mineral concentrations, of (-)-epicatechin, (+)-catechin, and rutin ingestion prior to, and during pregnancy and lactation in C57BL/6J mice. Toxicol Rep. 2015; 2:443-449. PMID: 28962380.
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    25. Scherr RE, Linnell JD, Smith MH, Briggs M, Bergman J, Brian KM, Dharmar M, Feenstra G, Hillhouse C, Keen CL, Nguyen LM, Nicholson Y, Ontai L, Schaefer SE, Spezzano T, Steinberg FM, Sutter C, Wright JE, Young HM, Zidenberg-Cherr S. The Shaping Healthy Choices Program: design and implementation methodologies for a multicomponent, school-based nutrition education intervention. J Nutr Educ Behav. 2014 Nov-Dec; 46(6):e13-21. PMID: 25457732.
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    26. Borchers AT, Keen CL, Huntley AC, Gershwin ME. Lyme disease: a rigorous review of diagnostic criteria and treatment. J Autoimmun. 2015 Feb; 57:82-115. PMID: 25451629.
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    27. Burke KE, Zhou X, Wang Y, Commisso J, Keen CL, Nakamura RM, Combs GF, Wei H. The effects of topical L-selenomethionine on protection against UVB-induced skin cancer when given before, during, and after UVB exposure. J Drugs Dermatol. 2014 Oct; 13(10):1214-23. PMID: 25607556.
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    28. Hackman RM, Aggarwal BB, Applebaum RS, deVere White RW, Dubick MA, Heber D, Ito T, Johnson GH, Keen CL, Winters BL, Stohs SJ. Forecasting nutrition research in 2020. J Am Coll Nutr. 2014; 33(4):340-6. PMID: 25144361.
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    29. Le A, Shibata NM, French SW, Kim K, Kharbanda KK, Islam MS, LaSalle JM, Halsted CH, Keen CL, Medici V. Characterization of timed changes in hepatic copper concentrations, methionine metabolism, gene expression, and global DNA methylation in the Jackson toxic milk mouse model of Wilson disease. Int J Mol Sci. 2014 May 07; 15(5):8004-23. PMID: 24810691.
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    30. Medici V, Shibata NM, Kharbanda KK, Islam MS, Keen CL, Kim K, Tillman B, French SW, Halsted CH, LaSalle JM. Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the tx-j mouse model of Wilson disease. Epigenetics. 2014 Feb; 9(2):286-96. PMID: 24220304.
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    31. Chowanadisai W, Graham DM, Keen CL, Rucker RB, Messerli MA. A zinc transporter gene required for development of the nervous system. Commun Integr Biol. 2013 Nov 01; 6(6):e26207. PMID: 24567773.
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    32. Chowanadisai W, Graham DM, Keen CL, Rucker RB, Messerli MA. Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9903-8. PMID: 23716681.
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    33. Uriu-Adams JY, Obican SG, Keen CL. Vitamin D and maternal and child health: overview and implications for dietary requirements. Birth Defects Res C Embryo Today. 2013 Mar; 99(1):24-44. PMID: 23723170.
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    34. Zunino SJ, Storms DH, Newman JW, Pedersen TL, Keen CL, Ducore JM. Oral or parenteral administration of curcumin does not prevent the growth of high-risk t(4;11) acute lymphoblastic leukemia cells engrafted into a NOD/SCID mouse model. Int J Oncol. 2013 Feb; 42(2):741-8. PMID: 23232667.
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    35. Zunino SJ, Storms DH, Newman JW, Pedersen TL, Keen CL, Ducore JM. Dietary resveratrol does not delay engraftment, sensitize to vincristine or inhibit growth of high-risk acute lymphoblastic leukemia cells in NOD/SCID mice. Int J Oncol. 2012 Dec; 41(6):2207-12. PMID: 23041950.
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    36. Reiss R, Johnston J, Tucker K, DeSesso JM, Keen CL. Estimation of cancer risks and benefits associated with a potential increased consumption of fruits and vegetables. Food Chem Toxicol. 2012 Dec; 50(12):4421-7. PMID: 22981907.
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    37. Ottaviani JI, Kwik-Uribe C, Keen CL, Schroeter H. Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans. Am J Clin Nutr. 2012 Apr; 95(4):851-8. PMID: 22378733.
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    38. Holt RR, Heiss C, Kelm M, Keen CL. The potential of flavanol and procyanidin intake to influence age-related vascular disease. J Nutr Gerontol Geriatr. 2012; 31(3):290-323. PMID: 22888843.
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    39. Ottaviani JI, Momma TY, Kuhnle GK, Keen CL, Schroeter H. Structurally related (-)-epicatechin metabolites in humans: assessment using de novo chemically synthesized authentic standards. Free Radic Biol Med. 2012 Apr 15; 52(8):1403-12. PMID: 22240152.
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    40. Zunino SJ, Storms DH, Newman JW, Pedersen TL, Keen CL, Ducore JM. Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model. Int J Oncol. 2012 Apr; 40(4):1277-84. PMID: 22200740.
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    41. Hills JI, Golub MS, Bettendorff L, Keen CL. The effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice. Neurotoxicol Teratol. 2012 Mar; 34(2):242-52. PMID: 21816221.
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    42. Mackenzie GG, Salvador GA, Romero C, Keen CL, Oteiza PI. A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain. Free Radic Biol Med. 2011 Jul 15; 51(2):480-9. PMID: 21600978.
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    43. Borchers AT, Chang C, Keen CL, Gershwin ME. Idiopathic pulmonary fibrosis-an epidemiological and pathological review. Clin Rev Allergy Immunol. 2011 Apr; 40(2):117-34. PMID: 20838937.
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    44. Ottaviani JI, Momma TY, Heiss C, Kwik-Uribe C, Schroeter H, Keen CL. The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo. Free Radic Biol Med. 2011 Jan 15; 50(2):237-44. PMID: 21074608.
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    45. Chambers A, Krewski D, Birkett N, Plunkett L, Hertzberg R, Danzeisen R, Aggett PJ, Starr TB, Baker S, Dourson M, Jones P, Keen CL, Meek B, Schoeny R, Slob W. An exposure-response curve for copper excess and deficiency. J Toxicol Environ Health B Crit Rev. 2010 Oct; 13(7-8):546-78. PMID: 21170809.
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    46. Borchers A, Teuber SS, Keen CL, Gershwin ME. Food safety. Clin Rev Allergy Immunol. 2010 Oct; 39(2):95-141. PMID: 19911313.
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    47. Schroeter H, Heiss C, Spencer JP, Keen CL, Lupton JR, Schmitz HH. Recommending flavanols and procyanidins for cardiovascular health: current knowledge and future needs. Mol Aspects Med. 2010 Dec; 31(6):546-57. PMID: 20854838.
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    48. Heiss C, Keen CL, Kelm M. Flavanols and cardiovascular disease prevention. Eur Heart J. 2010 Nov; 31(21):2583-92. PMID: 20852295.
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    49. Shenoy SF, Kazaks AG, Holt RR, Chen HJ, Winters BL, Khoo CS, Poston WS, Haddock CK, Reeves RS, Foreyt JP, Gershwin ME, Keen CL. The use of a commercial vegetable juice as a practical means to increase vegetable intake: a randomized controlled trial. Nutr J. 2010 Sep 17; 9:38. PMID: 20849620.
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    50. Kalgaonkar S, Nishioka H, Gross HB, Fujii H, Keen CL, Hackman RM. Bioactivity of a flavanol-rich lychee fruit extract in adipocytes and its effects on oxidant defense and indices of metabolic syndrome in animal models. Phytother Res. 2010 Aug; 24(8):1223-8. PMID: 20309950.
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    51. Uriu-Adams JY, Keen CL. Zinc and reproduction: effects of zinc deficiency on prenatal and early postnatal development. Birth Defects Res B Dev Reprod Toxicol. 2010 Aug; 89(4):313-25. PMID: 20803691.
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    52. Brewer GJ. Toxicity of copper in drinking water. J Toxicol Environ Health B Crit Rev. 2010 Aug; 13(6):449-52; author reply 453-9. PMID: 20711927.
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    53. Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile N, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol. 2010 Jul 13; 56(3):218-24. PMID: 20620742.
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    54. Uriu-Adams JY, Scherr RE, Lanoue L, Keen CL. Influence of copper on early development: prenatal and postnatal considerations. Biofactors. 2010 Mar-Apr; 36(2):136-52. PMID: 20232410.
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    55. Keen CL, Uriu-Adams JY, Skalny A, Grabeklis A, Grabeklis S, Green K, Yevtushok L, Wertelecki WW, Chambers CD. The plausibility of maternal nutritional status being a contributing factor to the risk for fetal alcohol spectrum disorders: the potential influence of zinc status as an example. Biofactors. 2010 Mar-Apr; 36(2):125-35. PMID: 20333752.
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    56. Gershwin ME, Borchers AT, Keen CL, Hendler S, Hagie F, Greenwood MR. Public safety and dietary supplementation. Ann N Y Acad Sci. 2010 Mar; 1190:104-17. PMID: 20388141.
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    57. Fujimoto M, Tsuneyama K, Kinoshita H, Goto H, Takano Y, Selmi C, Keen CL, Gershwin ME, Shimada Y. The traditional Japanese formula keishibukuryogan reduces liver injury and inflammation in patients with nonalcoholic fatty liver disease. Ann N Y Acad Sci. 2010 Mar; 1190:151-8. PMID: 20388146.
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    58. Shenoy SF, Poston WS, Reeves RS, Kazaks AG, Holt RR, Keen CL, Chen HJ, Haddock CK, Winters BL, Khoo CS, Foreyt JP. Weight loss in individuals with metabolic syndrome given DASH diet counseling when provided a low sodium vegetable juice: a randomized controlled trial. Nutr J. 2010 Feb 23; 9:8. PMID: 20178625.
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    59. Hanna LA, Clegg MS, Ellis-Hutchings RG, Niles BJ, Keen CL. The influence of gestational zinc deficiency on the fetal insulin-like growth factor axis in the rat. Exp Biol Med (Maywood). 2010 Feb; 235(2):206-14. PMID: 20404036.
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    60. Kalgaonkar S, Gross HB, Yokoyama W, Keen CL. Effects of a flavonol-rich diet on select cardiovascular parameters in a Golden Syrian hamster model. J Med Food. 2010 Feb; 13(1):108-15. PMID: 20136443.
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    61. Adamo AM, Zago MP, Mackenzie GG, Aimo L, Keen CL, Keenan A, Oteiza PI. The role of zinc in the modulation of neuronal proliferation and apoptosis. Neurotox Res. 2010 Jan; 17(1):1-14. PMID: 19784710.
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    62. Lanoue L, Green KK, Kwik-Uribe C, Keen CL. Dietary factors and the risk for acute infant leukemia: evaluating the effects of cocoa-derived flavanols on DNA topoisomerase activity. Exp Biol Med (Maywood). 2010 Jan; 235(1):77-89. PMID: 20404022.
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    63. Borchers AT, Naguwa SM, Keen CL, Gershwin ME. The implications of autoimmunity and pregnancy. J Autoimmun. 2010 May; 34(3):J287-99. PMID: 20031371.
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    64. Williamson G, Sies H, Heber D, Keen CL, Macdonald IA, Actis-Goretta L, Actis-Gorreta L, Momma TY, Ottaviani JI, Holt RR, Schroeter H, Heiss C. Functional foods for health promotion: state-of-the-science on dietary flavonoids. Extended abstracts from the 12th Annual Conference on Functional Foods for Health Promotion, April 2009. Nutr Rev. 2009 Dec; 67(12):736-43. PMID: 19941619.
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    65. Stohs SJ, Preuss HG, Ohia SE, Kaats GR, Keen CL, Williams LD, Burdock GA. No evidence demonstrating hepatotoxicity associated with hydroxycitric acid. World J Gastroenterol. 2009 Aug 28; 15(32):4087-9. PMID: 19705510.
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    66. Mackenzie GG, Delfino JM, Keen CL, Fraga CG, Oteiza PI. Dimeric procyanidins are inhibitors of NF-kappaB-DNA binding. Biochem Pharmacol. 2009 Nov 01; 78(9):1252-62. PMID: 19591805.
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    67. Borchers AT, Shimoda S, Bowlus C, Keen CL, Gershwin ME. Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis. Semin Immunopathol. 2009 Sep; 31(3):309-22. PMID: 19533132.
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    68. Kenny TP, Shu SA, Moritoki Y, Keen CL, Gershwin ME. Cocoa flavanols and procyanidins can modulate the lipopolysaccharide activation of polymorphonuclear cells in vitro. J Med Food. 2009 Feb; 12(1):1-7. PMID: 19298189.
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    69. Ellis-Hutchings RG, Cherr GN, Hanna LA, Keen CL. The effects of marginal maternal vitamin A status on penta-brominated diphenyl ether mixture-induced alterations in maternal and conceptal vitamin A and fetal development in the Sprague Dawley rat. Birth Defects Res B Dev Reprod Toxicol. 2009 Feb; 86(1):48-57. PMID: 19145591.
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    70. Borchers AT, Selmi C, Meyers FJ, Keen CL, Gershwin ME. Probiotics and immunity. J Gastroenterol. 2009; 44(1):26-46. PMID: 19159071.
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    71. DeSesso JM, Watson RE, Keen CL, Hazelden KP, Haws LC, Li AA. Analysis and integration of developmental neurotoxicity and ancillary data into risk assessment: a case study of dimethoate. J Toxicol Environ Health A. 2009; 72(2):94-109. PMID: 19034799.
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    72. Selmi C, Cocchi CA, Lanfredini M, Keen CL, Gershwin ME. Chocolate at heart: the anti-inflammatory impact of cocoa flavanols. Mol Nutr Food Res. 2008 Nov; 52(11):1340-8. PMID: 18991246.
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    73. Balzer J, Rassaf T, Heiss C, Kleinbongard P, Lauer T, Merx M, Heussen N, Gross HB, Keen CL, Schroeter H, Kelm M. Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial. J Am Coll Cardiol. 2008 Jun 03; 51(22):2141-9. PMID: 18510961.
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    74. Devaraj S, Wang-Polagruto J, Polagruto J, Keen CL, Jialal I. High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome. Metabolism. 2008 Jun; 57(6):867-70. PMID: 18502272.
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    75. Actis-Goretta L, Romanczyk LJ, Rodriguez CA, Kwik-Uribe C, Keen CL. Cytotoxic effects of digalloyl dimer procyanidins in human cancer cell lines. J Nutr Biochem. 2008 Dec; 19(12):797-808. PMID: 18440795.
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    76. Borchers AT, Keen CL, Gershwin ME. Smoking cessation: significance and implications for children. Clin Rev Allergy Immunol. 2008 Apr; 34(2):231-49. PMID: 17999199.
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    77. Schnorr O, Brossette T, Momma TY, Kleinbongard P, Keen CL, Schroeter H, Sies H. Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo. Arch Biochem Biophys. 2008 Aug 15; 476(2):211-5. PMID: 18348861.
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    78. Borchers AT, Krishnamurthy A, Keen CL, Meyers FJ, Gershwin ME. The immunobiology of mushrooms. Exp Biol Med (Maywood). 2008 Mar; 233(3):259-76. PMID: 18296732.
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    79. Lopez V, Keen CL, Lanoue L. Prenatal zinc deficiency: influence on heart morphology and distribution of key heart proteins in a rat model. Biol Trace Elem Res. 2008 Jun; 122(3):238-55. PMID: 18224284.
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    80. Gu YS, Kong J, Cheema GS, Keen CL, Wick G, Gershwin ME. The immunobiology of systemic sclerosis. Semin Arthritis Rheum. 2008 Oct; 38(2):132-60. PMID: 18221988.
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    81. Niles BJ, Clegg MS, Hanna LA, Chou SS, Momma TY, Hong H, Keen CL. Zinc deficiency-induced iron accumulation, a consequence of alterations in iron regulatory protein-binding activity, iron transporters, and iron storage proteins. J Biol Chem. 2008 Feb 22; 283(8):5168-77. PMID: 18073202.
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    82. Selmi C, Bowlus CL, Keen CL, Gershwin ME. Non-alcoholic fatty liver disease: the new epidemic and the need for novel nutritional approaches. J Med Food. 2007 Dec; 10(4):563-5. PMID: 18158823.
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    83. Selmi C, Montano N, Furlan R, Keen CL, Gershwin ME. Inflammation and oxidative stress in obstructive sleep apnea syndrome. Exp Biol Med (Maywood). 2007 Dec; 232(11):1409-13. PMID: 18040064.
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    84. Chang C, Keen CL, Gershwin ME. Treatment of eczema. Clin Rev Allergy Immunol. 2007 Dec; 33(3):204-25. PMID: 18163227.
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    85. Polagruto JA, Gross HB, Kamangar F, Kosuna K, Sun B, Fujii H, Keen CL, Hackman RM. Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract. J Med Food. 2007 Dec; 10(4):725-30. PMID: 18158849.
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    86. Shenoy SF, Keen CL, Kalgaonkar S, Polagruto JA. Effects of grape seed extract consumption on platelet function in postmenopausal women. Thromb Res. 2007; 121(3):431-2. PMID: 17950783.
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    87. Yang SJ, Keen CL, Lanoue L, Rucker RB, Uriu-Adams JY. Low nitric oxide: a key factor underlying copper-deficiency teratogenicity. Free Radic Biol Med. 2007 Dec 15; 43(12):1639-48. PMID: 18037129.
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    88. Danzeisen R, Araya M, Harrison B, Keen C, Solioz M, Thiele D, McArdle HJ. How reliable and robust are current biomarkers for copper status? Br J Nutr. 2007 Oct; 98(4):676-83. PMID: 17666147.
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    89. Borchers AT, Keen CL, Gershwin ME. Drug-induced lupus. Ann N Y Acad Sci. 2007 Jun; 1108:166-82. PMID: 17893983.
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    90. Stern BR, Solioz M, Krewski D, Aggett P, Aw TC, Baker S, Crump K, Dourson M, Haber L, Hertzberg R, Keen C, Meek B, Rudenko L, Schoeny R, Slob W, Starr T. Copper and human health: biochemistry, genetics, and strategies for modeling dose-response relationships. J Toxicol Environ Health B Crit Rev. 2007 Apr-May; 10(3):157-222. PMID: 17454552.
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    317. Keen CL, German BJ, Mareschi JP, Gershwin ME. Nutritional modulation of murine models of autoimmunity. Rheum Dis Clin North Am. 1991 May; 17(2):223-34. PMID: 1862234.
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    326. Walter RM, Keen CL. SI units: a wholehearted effort is needed. JAMA. 1990 Aug 22-29; 264(8):974. PMID: 2376889.
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    347. Muñoz LM, Lönnerdal B, Keen CL, Dewey KG. Coffee consumption as a factor in iron deficiency anemia among pregnant women and their infants in Costa Rica. Am J Clin Nutr. 1988 Sep; 48(3):645-51. PMID: 3414579.
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    355. Peters JM, Lönnerdal B, Keen CL. Effect of the antihypertensive drug hydralazine on mineral metabolism in the rat. Toxicol Lett. 1988 Jun; 41(3):193-202. PMID: 3376146.
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    358. McDonald R, Keen CL. Iron, zinc and magnesium nutrition and athletic performance. Sports Med. 1988 Mar; 5(3):171-84. PMID: 3285436.
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    366. Kawano J, Ney DM, Keen CL, Schneeman BO. Altered high density lipoprotein composition in manganese-deficient Sprague-Dawley and Wistar rats. J Nutr. 1987 May; 117(5):902-6. PMID: 3585544.
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    367. Dubick MA, Hunter GC, Casey SM, Keen CL. Aortic ascorbic acid, trace elements, and superoxide dismutase activity in human aneurysmal and occlusive disease. Proc Soc Exp Biol Med. 1987 Feb; 184(2):138-43. PMID: 3809168.
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    372. Mieden GD, Keen CL, Hurley LS, Klein NW. Effects of whole rat embryos cultured on serum from zinc- and copper-deficient rats. J Nutr. 1986 Dec; 116(12):2424-31. PMID: 3806239.
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    373. Amemiya K, Keen CL, Hurley LS. 6-Mercaptopurine-induced alterations in mineral metabolism and teratogenesis in the rat. Teratology. 1986 Dec; 34(3):321-34. PMID: 3798368.
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    375. Kawamoto JC, Castonguay TW, Keen CL, Stern JS, Hurley LS. Age, sex and reproductive status alter the severity of anorexia in zinc deficient rats. Physiol Behav. 1986 Oct; 38(4):485-93. PMID: 3469681.
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    380. Zidenberg-Cherr S, Keen CL. Influence of dietary manganese and vitamin E on adriamycin toxicity in mice. Toxicol Lett. 1986 Jan; 30(1):79-87. PMID: 3952776.
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    384. Uriu-Hare JY, Stern JS, Reaven GM, Keen CL. The effect of maternal diabetes on trace element status and fetal development in the rat. Diabetes. 1985 Oct; 34(10):1031-40. PMID: 4043553.
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    389. Baly DL, Curry DL, Keen CL, Hurley LS. Dynamics of insulin and glucagon release in rats: influence of dietary manganese. Endocrinology. 1985 May; 116(5):1734-40. PMID: 3886366.
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    391. Amemiya K, Hurley LS, Keen CL. Effect of the anticarcinogenic drug 6-mercaptopurine on mineral metabolism in the mouse. Toxicol Lett. 1985 Apr; 25(1):55-62. PMID: 4039479.
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    393. Dubick MA, Keen CL, Rucker RB. Elastin metabolism during perinatal lung development in the copper-deficient rat. Exp Lung Res. 1985; 8(4):227-41. PMID: 2864245.
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    396. Branam JE, Keen CL, Ling GV, Franti CE. Selected physical and chemical characteristics of prostatic fluid collected by ejaculation from healthy dogs and from dogs with bacterial prostatitis. Am J Vet Res. 1984 Apr; 45(4):825-9. PMID: 6732000.
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    399. Hurley LS, Keen CL, Baly DL. Manganese deficiency and toxicity: effects on carbohydrate metabolism in the rat. Neurotoxicology. 1984; 5(1):97-104. PMID: 6371607.
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    404. Hurley LS, Dungan DD, Keen CL, Lönnerdal B. The effects of vitamin E on zinc deficiency teratogenesis in rats. J Nutr. 1983 Sep; 113(9):1875-7. PMID: 6886830.
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    405. Masters DG, Keen CL, Lönnerdal B, Hurley LS. Comparative aspects of dietary copper and zinc deficiencies in pregnant rats. J Nutr. 1983 Jul; 113(7):1448-51. PMID: 6864343.
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    406. Dubick MA, Keen CL. Tissue trace elements and lung superoxide dismutase activity in mice exposed to ozone. Toxicol Lett. 1983 Jul; 17(3-4):355-60. PMID: 6623529.
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    407. Schneeman BO, Lönnerdal B, Keen CL, Hurley LS. Zinc and copper in rat bile and pancreatic fluid: effects of surgery. J Nutr. 1983 Jun; 113(6):1165-8. PMID: 6854411.
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    408. Cohen NL, Keen CL, Lönnerdal B, Hurley LS. The effect of copper chelating drugs on liver iron mobilization in the adult rat. Biochem Biophys Res Commun. 1983 May 31; 113(1):127-34. PMID: 6860330.
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    409. Keen CL, Clegg MS, Lönnerdal B, Hurley LS. Whole-blood manganese as an indicator of body manganese. N Engl J Med. 1983 May 19; 308(20):1230. PMID: 6843605.
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    410. Lönnerdal B, Keen CL, Ohtake M, Tamura T. Iron, zinc, copper, and manganese in infant formulas. Am J Dis Child. 1983 May; 137(5):433-7. PMID: 6846270.
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    411. Masters DG, Keen CL, Lönnerdal B, Hurley LS. Zinc deficiency teratogenicity: the protective role of maternal tissue catabolism. J Nutr. 1983 Apr; 113(4):905-12. PMID: 6834156.
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    412. Hurley LS, Keen CL, Lönnerdal B. Aspects of trace element interactions during development. Fed Proc. 1983 Apr; 42(6):1735-9. PMID: 6832396.
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    413. Cohen NL, Keen CL, Lönnerdal B, Hurley LS. The effect of copper supplementation on the teratogenic effects of triethylenetetramine in rats. Drug Nutr Interact. 1983; 2(3):203-10. PMID: 6678759.
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    414. Zidenberg-Cherr S, Keen CL, Lönnerdal B, Hurley LS. Dietary superoxide dismutase does not affect tissue levels. Am J Clin Nutr. 1983 Jan; 37(1):5-7. PMID: 6849282.
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    415. Keen CL, Mark-Savage P, Lönnerdal B, Hurley LS. Teratogenic effects of D-penicillamine in rats: relation to copper deficiency. Drug Nutr Interact. 1983; 2(1):17-34. PMID: 6678745.
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    416. Keen CL, Mark-Savage P, Lönnerdal B, Hurley LS. Teratogenesis and low copper status resulting from D-penicillamine in rats. Teratology. 1982 Oct; 26(2):163-5. PMID: 7157192.
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    417. Keen CL, Feldman BF, Knight J, O'Neill S, Ferrell F, Hurley LS. The influence of high concentrations of dietary copper on vitamin K-dependent coagulation factors. Proc Soc Exp Biol Med. 1982 Sep; 170(4):471-5. PMID: 7122476.
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    418. Keen CL, Lonnerdal B, Clegg MS, Hurley LS, Morris JG, Rogers QR, Rucker RB. Developmental changes in composition of cats milk: trace elements, minerals, protein, carbohydrate and fat. J Nutr. 1982 Sep; 112(9):1763-9. PMID: 6213745.
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    419. Dressendorfer RH, Wade CE, Keen CL, Scaff JH. Plasma Mineral Levels in Marathon Runners During a 20-Day Road Race. Phys Sportsmed. 1982 Jun; 10(6):113-118. PMID: 29261062.
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    420. Hurley LS, Gordon P, Keen CL, Merkhofer L. Circadian variation in rat plasma zinc and rapid effect of dietary zinc deficiency. Proc Soc Exp Biol Med. 1982 May; 170(1):48-52. PMID: 7079271.
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    421. Keen CL, Lönnerdal B, Hurley LS. Increased milk iron by dietary supplementation-entirely beneficial? Am J Clin Nutr. 1982 Mar; 35(3):627-8. PMID: 7064913.
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    422. Stein TN, Keen CL, Lönnerdal B, Hurley LS. Effect of sample preparation on analysis of superoxide dismutase activity and isoenzymes. J Inorg Biochem. 1982 Feb; 16(1):71-7. PMID: 7086404.
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    423. Hurley LS, Keen CL, Lönnerdal B. Trace elements and teratology: an interactional perspective. Basic Life Sci. 1982; 21:189-99. PMID: 6756376.
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    424. Shrader RE, Keen CL, Hurley LS, Zeman FJ. Hematologic and trace element alterations following chronic maternal ingestion of propylthiourea. Exp Hematol. 1982 Jan; 10(1):44-55. PMID: 7060660.
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    425. Keen CL, Lönnerdal B, Fisher GL. Age-related variations in hepatic iron, copper, zinc, and selenium concentrations in beagles. Am J Vet Res. 1981 Nov; 42(11):1884-7. PMID: 7337285.
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    426. Feldman BF, Keen CL, Kaneko JJ, Farver TB. Anemia of inflammatory disease in the dog: measurement of hepatic superoxide dismutase, hepatic nonheme iron, copper, zinc, and ceruloplasmin and serum iron, copper, and zinc. Am J Vet Res. 1981 Jul; 42(7):1114-7. PMID: 7271025.
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    427. Lönnerdal B, Keen CL, Hurley LS, Fisher GL. Developmental changes in the composition of Beagle dog milk. Am J Vet Res. 1981 Apr; 42(4):662-6. PMID: 7199265.
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    428. Keen CL, Lonnerdal B, Fisher GL. Seasonal variations and the effects of age on serum copper and zinc values in the dog. Am J Vet Res. 1981 Feb; 42(2):347-50. PMID: 7258789.
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    429. Keen CL, Lönnerdal B, Clegg M, Hurley LS. Developmental changes in composition of rat milk: trace elements, minerals, protein, carbohydrate and fat. J Nutr. 1981 Feb; 111(2):226-36. PMID: 7463167.
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    430. Lönnerdal B, Keen CL, Hurley LS. Iron, copper, zinc, and manganese in milk. Annu Rev Nutr. 1981; 1:149-74. PMID: 6764714.
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    431. Lönnerdal B, Keen CL, Sloan MV, Hurley LS. Molecular localization of zinc in rat milk and neonatal intestine. J Nutr. 1980 Dec; 110(12):2414-9. PMID: 7441371.
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    432. Indrieri RJ, Holliday TA, Keen CL. Critical evaluation of creatine phosphokinase in cerebrospinal fluid of dogs with neurologic disease. Am J Vet Res. 1980 Aug; 41(8):1299-303. PMID: 7447126.
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    433. Keen CL, Hurley LS. Developmental changes in concentrations of iron, copper, and zinc in mouse tissues. Mech Ageing Dev. 1980 Jun; 13(2):161-76. PMID: 7432004.
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    434. Keen CL, Lönnerdal B, Sloan MV, Hurley LS. Effect of dietary iron, copper and zinc chelates of nitrilotriacetic acid (NTA) on trace metal concentrations in rat milk and maternal and pup tissues. J Nutr. 1980 May; 110(5):897-906. PMID: 7373436.
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    435. de Rosa G, Keen CL, Leach RM, Hurley LS. Regulation of superoxide dismutase activity by dietary manganese. J Nutr. 1980 Apr; 110(4):795-804. PMID: 7365547.
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    436. Keen CL, Lönnerdal B, Sloan MV, Hurley LS. Effects of milking procedure on rat milk composition. Physiol Behav. 1980 Mar; 24(3):613-5. PMID: 7375582.
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    437. Lönnerdal B, Keen CL, Hambraeus L, Hurley LS. New perspectives on iron supplementation of milk. J Pediatr. 1980 Feb; 96(2):242. PMID: 7351586.
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    438. Hurley LS, Keen CL, Lönnerdal B. Copper in fetal and neonatal development. Ciba Found Symp. 1980; 79:227-45. PMID: 6907085.
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    439. Lönnerdal B, Keen CL, Hurley LS. Isoelectric focusing of superoxide dismutase isoenzymes. FEBS Lett. 1979 Dec 01; 108(1):51-5. PMID: 520563.
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    440. Keen CL, Hurley LS. Developmental patterns of copper and zinc concentrations in mouse liver and brain: evidence that the gene crinkled (cr) is associated with an abnormality in copper metabolism. J Inorg Biochem. 1979 Nov; 11(3):269-77. PMID: 512661.
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    441. Keen CL, Hurley LS. Superoxide dismutase activity in the crinkled mutant mouse: ameliorative effects of dietary copper supplementation. Proc Soc Exp Biol Med. 1979 Oct; 162(1):152-6. PMID: 504225.
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    442. De Rosa G, Duncan DS, Keen CL, Hurley LS. Evaluation of negative staining technique for determination of CN--insensitive superoxide dismutase activity. Biochim Biophys Acta. 1979 Jan 12; 566(1):32-9. PMID: 758957.
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    443. Keen CL, Hurley LS. Copper supplementation in quaking mutant mice: reduced tremors and increased brain copper. Science. 1976 Jul 16; 193(4249):244-6. PMID: 945613.
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