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Natural Products and Diabetes: (-)-Epicatechin and Mechanisms Involved in the Regulation of Insulin Sensitivity. Handb Exp Pharmacol. 2024 Mar 01.
Fraga CG, Cremonini E, Galleano M, Oteiza PI. PMID: 38421444.
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PubMed Mentions: Fields:
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Anthocyanins and their metabolites promote white adipose tissue beiging by regulating mitochondria thermogenesis and dynamics. Biochem Pharmacol. 2024 Feb 20; 222:116069.
Cremonini E, Da Silva LME, Lanzi CR, Marino M, Iglesias DE, Oteiza PI. PMID: 38387526.
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PubMed Mentions: Fields:
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Corrigendum to "Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice" [Int. J. Biochem Cell Biol. 81 (2016) 383-392]. Int J Biochem Cell Biol. 2024 Feb 07; 169:106534.
Bettaieb A, Cremonini E, Kang H, Kang J, Haj FG, Oteiza PI. PMID: 38330896.
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PubMed Mentions: Fields:
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Effects of (-)-epicatechin on hepatic triglyceride metabolism. Food Funct. 2024 Jan 02; 15(1):326-337.
Mostofinejad Z, Cremonini E, Kang J, Oteiza PI. PMID: 38086683.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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(Poly)phenols and the regulation of NADPH oxidases. Redox Biol. 2023 11; 67:102927.
Fraga CG, Oteiza PI, Hid EJ, Galleano M. PMID: 37857000; PMCID: PMC10587761.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Marginal Zinc Deficiency during Gestation and Lactation in Rats Affects Oligodendrogenesis, Motor Performance, and Behavior in the Offspring. J Nutr. 2023 Oct; 153(10):2778-2796.
Liu X, Adamo AM, Oteiza PI. PMID: 37648111.
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PubMed Mentions: Fields:
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In Memoriam: Pierre Cillard (1942-2023). Free Radic Biol Med. 2023 Aug 10; 206:191-192.
Oteiza PI, Fraga CG, Cadenas E, Davies JMS, Davies KJA. PMID: 37572453.
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PubMed Mentions: Fields:
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NADPH oxidase 1: A target in the capacity of dimeric ECG and EGCG procyanidins to inhibit colorectal cancer cell invasion. Redox Biol. 2023 09; 65:102827.
Zhu W, Oteiza PI. PMID: 37516013; PMCID: PMC10410180.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Bioactives and human health. Mol Aspects Med. 2023 02; 89:101168.
Fraga CG, Oteiza PI. PMID: 36610861.
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PubMed Mentions: Fields:
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Anthocyanin actions at the gastrointestinal tract: Relevance to their health benefits. Mol Aspects Med. 2023 02; 89:101156.
Oteiza PI, Cremonini E, Fraga CG. PMID: 36379746.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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(-)-Epicatechin exerts positive effects on anxiety in high fat diet-induced obese mice through multi-genomic modifications in the hippocampus. Food Funct. 2022 Oct 17; 13(20):10623-10641.
Kang J, Oteiza PI, Milenkovic D. PMID: 36168829.
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PubMed Mentions: Fields:
Translation:
Animals
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(-)-Epicatechin mitigates anxiety-related behavior in a mouse model of high fat diet-induced obesity. J Nutr Biochem. 2022 Dec; 110:109158.
Kang J, Wang Z, Cremonini E, Le Gall G, Pontifex MG, Muller M, Vauzour D, Oteiza PI. PMID: 36150679.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Proanthocyanidins at the gastrointestinal tract: mechanisms involved in their capacity to mitigate obesity-associated metabolic disorders. Crit Rev Food Sci Nutr. 2024; 64(2):220-240.
Zhu W, Oteiza PI. PMID: 35943169.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Di-2-ethylhexyl phthalate affects zinc metabolism and neurogenesis in the developing rat brain. Arch Biochem Biophys. 2022 09 30; 727:109351.
Liu X, Adamo AM, Oteiza PI. PMID: 35841924.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Cyanidin and delphinidin restore colon physiology in high fat diet-fed mice: Involvement of TLR-4 and redox-regulated signaling. Free Radic Biol Med. 2022 08 01; 188:71-82.
Iglesias DE, Cremonini E, Hester SN, Wood SM, Bartlett M, Fraga CG, Oteiza PI. PMID: 35691508.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Curcumin Mitigates TNFα-Induced Caco-2 Cell Monolayer Permeabilization Through Modulation of NF-κB, ERK1/2, and JNK Pathways. Mol Nutr Food Res. 2022 Nov; 66(21):e2101033.
Iglesias DE, Cremonini E, Oteiza PI, Fraga CG. PMID: 35182412.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects. Redox Biol. 2022 05; 51:102273.
Cremonini E, Daveri E, Iglesias DE, Kang J, Wang Z, Gray R, Mastaloudis A, Kay CD, Hester SN, Wood SM, Fraga CG, Oteiza PI. PMID: 35255426; PMCID: PMC8902616.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Supplementation with cyanidin and delphinidin mitigates high fat diet-induced endotoxemia and associated liver inflammation in mice. Food Funct. 2022 Jan 24; 13(2):781-794.
Cremonini E, Iglesias DE, Matsukuma KE, Hester SN, Wood SM, Bartlett M, Fraga CG, Oteiza PI. PMID: 34981106.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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(-)-Epicatechin and Anthocyanins Modulate GLP-1 Metabolism: Evidence from C57BL/6J Mice and GLUTag Cells. J Nutr. 2021 06 01; 151(6):1497-1506.
Cremonini E, Daveri E, Mastaloudis A, Oteiza PI. PMID: 33693759; PMCID: PMC8659349.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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Gestational zinc deficiency impairs brain astrogliogenesis in rats through multistep alterations of the JAK/STAT3 signaling pathway. Redox Biol. 2021 08; 44:102017.
Supasai S, Adamo AM, Mathieu P, Marino RC, Hellmers AC, Cremonini E, Oteiza PI. PMID: 34049221; PMCID: PMC8167189.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Linking biomarkers of oxidative stress and disease with flavonoid consumption: From experimental models to humans. Redox Biol. 2021 06; 42:101914.
Oteiza PI, Fraga CG, Galleano M. PMID: 33750648; PMCID: PMC8113027.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Hexameric procyanidins inhibit colorectal cancer cell growth through both redox and non-redox regulation of the epidermal growth factor signaling pathway. Redox Biol. 2021 01; 38:101830.
Daveri E, Adamo AM, Alfine E, Zhu W, Oteiza PI. PMID: 33338921; PMCID: PMC7750420.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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The new era for research on polyphenols and food factors. Arch Biochem Biophys. 2020 12 15; 696:108678.
Oteiza PI, Toyokuni S. PMID: 33189654.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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(-)-Epicatechin and the comorbidities of obesity. Arch Biochem Biophys. 2020 09 15; 690:108505.
Cremonini E, Iglesias DE, Kang J, Lombardo GE, Mostofinejad Z, Wang Z, Zhu W, Oteiza PI. PMID: 32679195.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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(-)-Epicatechin mitigates high fat diet-induced neuroinflammation and altered behavior in mice. Food Funct. 2020 Jun 24; 11(6):5065-5076.
Kang J, Wang Z, Oteiza PI. PMID: 32432285.
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PubMed Mentions:
5 Fields:
Translation:
Animals
-
The inhibitory effect of ECG and EGCG dimeric procyanidins on colorectal cancer cells growth is associated with their actions at lipid rafts and the inhibition of the epidermal growth factor receptor signaling. Biochem Pharmacol. 2020 05; 175:113923.
Zhu W, Li MC, Wang FR, Mackenzie GG, Oteiza PI. PMID: 32217102; PMCID: PMC7489796.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Grape pomace extract supplementation activates FNDC5/irisin in muscle and promotes white adipose browning in rats fed a high-fat diet. Food Funct. 2020 Feb 26; 11(2):1537-1546.
Rodriguez Lanzi C, Perdicaro DJ, Gambarte Tudela J, Muscia V, Fontana AR, Oteiza PI, Vazquez Prieto MA. PMID: 31998896.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Quercetin attenuates adipose hypertrophy, in part through activation of adipogenesis in rats fed a high-fat diet. J Nutr Biochem. 2020 05; 79:108352.
Perdicaro DJ, Rodriguez Lanzi C, Gambarte Tudela J, Miatello RM, Oteiza PI, Vazquez Prieto MA. PMID: 32145471.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Ellagic acid protects Caco-2 cell monolayers against inflammation-induced permeabilization. Free Radic Biol Med. 2020 05 20; 152:776-786.
Iglesias DE, Cremonini E, Fraga CG, Oteiza PI. PMID: 31981623.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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(-)-Epicatechin and NADPH oxidase inhibitors prevent bile acid-induced Caco-2 monolayer permeabilization through ERK1/2 modulation. Redox Biol. 2020 01; 28:101360.
Wang Z, Litterio MC, Müller M, Vauzour D, Oteiza PI. PMID: 31677553; PMCID: PMC6920094.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Assessing the Fate and Bioavailability of Glucosinolates in Kale (Brassica oleracea) Using Simulated Human Digestion and Caco-2 Cell Uptake Models. J Agric Food Chem. 2019 Aug 28; 67(34):9492-9500.
Hwang ES, Bornhorst GM, Oteiza PI, Mitchell AE. PMID: 31374175.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis. Redox Biol. 2019 09; 26:101269.
Cremonini E, Daveri E, Mastaloudis A, Adamo AM, Mills D, Kalanetra K, Hester SN, Wood SM, Fraga CG, Oteiza PI. PMID: 31330482; PMCID: PMC6646927.
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PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Early Developmental Marginal Zinc Deficiency Affects Neurogenesis Decreasing Neuronal Number and Altering Neuronal Specification in the Adult Rat Brain. Front Cell Neurosci. 2019; 13:62.
Adamo AM, Liu X, Mathieu P, Nuttall JR, Supasai S, Oteiza PI. PMID: 30890920; PMCID: PMC6414196.
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PubMed Mentions:
17
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(-)-Epicatechin in the control of glucose homeostasis: Involvement of redox-regulated mechanisms. Free Radic Biol Med. 2019 01; 130:478-488.
Cremonini E, Fraga CG, Oteiza PI. PMID: 30447350.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Bioactives and their impact on human health. Mol Aspects Med. 2018 06; 61:1.
Fraga CG, Oteiza PI. PMID: 29907195.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Introduction to special issue on Polyphenols and Health. Arch Biochem Biophys. 2018 08 15; 652:1-2.
Oteiza PI, Heiss C. PMID: 29860030.
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PubMed Mentions: Fields:
Translation:
Humans
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Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice. Redox Biol. 2018 09; 18:16-24.
Daveri E, Cremonini E, Mastaloudis A, Hester SN, Wood SM, Waterhouse AL, Anderson M, Fraga CG, Oteiza PI. PMID: 29890336; PMCID: PMC6035912.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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(-)-Epicatechin and its metabolites prevent palmitate-induced NADPH oxidase upregulation, oxidative stress and insulin resistance in HepG2 cells. Arch Biochem Biophys. 2018 05 15; 646:55-63.
Cremonini E, Oteiza PI. PMID: 29608879.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Grape pomace extract induced beige cells in white adipose tissue from rats and in 3T3-L1 adipocytes. J Nutr Biochem. 2018 06; 56:224-233.
Rodriguez Lanzi C, Perdicaro DJ, Landa MS, Fontana A, Antoniolli A, Miatello RM, Oteiza PI, Vazquez Prieto MA. PMID: 29631143.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Plant bioactives and redox signaling: (-)-Epicatechin as a paradigm. Mol Aspects Med. 2018 06; 61:31-40.
Fraga CG, Oteiza PI, Galleano M. PMID: 29421170.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Flavonoids and the gastrointestinal tract: Local and systemic effects. Mol Aspects Med. 2018 06; 61:41-49.
Oteiza PI, Fraga CG, Mills DA, Taft DH. PMID: 29317252.
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PubMed Mentions:
71 Fields:
Translation:
Humans
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(-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance. Redox Biol. 2018 04; 14:588-599.
Cremonini E, Wang Z, Bettaieb A, Adamo AM, Daveri E, Mills DA, Kalanetra KM, Haj FG, Karakas S, Oteiza PI. PMID: 29154190; PMCID: PMC5691220.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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Anthocyanins inhibit tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity. Food Funct. 2017 Aug 01; 8(8):2915-2923.
Cremonini E, Mastaloudis A, Hester SN, Verstraeten SV, Anderson M, Wood SM, Waterhouse AL, Fraga CG, Oteiza PI. PMID: 28740990.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Combined Effects of Gestational Phthalate Exposure and Zinc Deficiency on Steroid Metabolism and Growth. Toxicol Sci. 2017 04 01; 156(2):469-479.
Nuttall JR, Kucera HR, Supasai S, Gaikwad NW, Oteiza PI. PMID: 28115639; PMCID: PMC5837672.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsPHPublic Health
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Aldosterone activates the oncogenic signals ERK1/2 and STAT3 via redox-regulated mechanisms. Mol Carcinog. 2017 08; 56(8):1868-1883.
Queisser N, Schupp N, Schwarz E, Hartmann C, Mackenzie GG, Oteiza PI. PMID: 28272757.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice. Int J Biochem Cell Biol. 2016 12; 81(Pt B):383-392.
Bettaieb A, Cremonini E, Kang H, Kang J, Haj FG, Oteiza PI. PMID: 27592457; PMCID: PMC5514545.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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(-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice. Arch Biochem Biophys. 2016 06 01; 599:13-21.
Cremonini E, Bettaieb A, Haj FG, Fraga CG, Oteiza PI. PMID: 26968772; PMCID: PMC5523407.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth. Mol Carcinog. 2016 12; 55(12):2196-2209.
Choy YY, Fraga M, Mackenzie GG, Waterhouse AL, Cremonini E, Oteiza PI. PMID: 26774105.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Nutritional marginal zinc deficiency disrupts placental 11β-hydroxysteroid dehydrogenase type 2 modulation. Food Funct. 2016 Jan; 7(1):84-92.
Huang YL, Supasai S, Kucera H, Gaikwad NW, Adamo AM, Mathieu P, Oteiza PI. PMID: 26645329.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Dietary (-)-epicatechin mitigates oxidative stress, NO metabolism alterations, and inflammation in renal cortex from fructose-fed rats. Free Radic Biol Med. 2016 Jan; 90:35-46.
Prince PD, Lanzi CR, Toblli JE, Elesgaray R, Oteiza PI, Fraga CG, Galleano M. PMID: 26569027.
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PubMed Mentions:
30 Fields:
Translation:
Animals
-
Gestational marginal zinc deficiency impaired fetal neural progenitor cell proliferation by disrupting the ERK1/2 signaling pathway. J Nutr Biochem. 2015 Nov; 26(11):1116-23.
Nuttall JR, Supasai S, Kha J, Vaeth BM, Mackenzie GG, Adamo AM, Oteiza PI. PMID: 26153680.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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(-)-Epicatechin reduces blood pressure increase in high-fructose-fed rats: effects on the determinants of nitric oxide bioavailability. J Nutr Biochem. 2015 Jul; 26(7):745-51.
Litterio MC, Vazquez Prieto MA, Adamo AM, Elesgaray R, Oteiza PI, Galleano M, Fraga CG. PMID: 25943039.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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(-)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity. Arch Biochem Biophys. 2015 May 01; 573:84-91.
Contreras TC, Ricciardi E, Cremonini E, Oteiza PI. PMID: 25795020.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes. Mol Nutr Food Res. 2015 Apr; 59(4):622-33.
Vazquez Prieto MA, Bettaieb A, Rodriguez Lanzi C, Soto VC, Perdicaro DJ, Galmarini CR, Haj FG, Miatello RM, Oteiza PI. PMID: 25620282; PMCID: PMC4408935.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Flavanols and vascular health: molecular mechanisms to build evidence-based recommendations. Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S12.
Fraga CG, Oteiza P. PMID: 26461285.
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PubMed Mentions:
3 Fields:
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Interactions of flavan-3-ols and procyanidins with membranes: mechanisms and the physiological relevance. Food Funct. 2015 Jan; 6(1):32-41.
Verstraeten SV, Fraga CG, Oteiza PI. PMID: 25418533.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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(-)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress. Free Radic Biol Med. 2014 Jul; 72:247-56.
Bettaieb A, Vazquez Prieto MA, Rodriguez Lanzi C, Miatello RM, Haj FG, Fraga CG, Oteiza PI. PMID: 24746618; PMCID: PMC4077617.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Aldosterone activates transcription factor Nrf2 in kidney cells both in vitro and in vivo. Antioxid Redox Signal. 2014 Nov 20; 21(15):2126-42.
Queisser N, Oteiza PI, Link S, Hey V, Stopper H, Schupp N. PMID: 24512358; PMCID: PMC4215337.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Zinc and the aging brain. Genes Nutr. 2014 Jan; 9(1):379.
Nuttall JR, Oteiza PI. PMID: 24366781; PMCID: PMC3896632.
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PubMed Mentions:
19
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Procyanidins can interact with Caco-2 cell membrane lipid rafts: involvement of cholesterol. Biochim Biophys Acta. 2013 Nov; 1828(11):2646-53.
Verstraeten SV, Jaggers GK, Fraga CG, Oteiza PI. PMID: 23899501.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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In vitro measurements and interpretation of total antioxidant capacity. Biochim Biophys Acta. 2014 Feb; 1840(2):931-4.
Fraga CG, Oteiza PI, Galleano M. PMID: 23830861.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets. Antioxid Redox Signal. 2013 Nov 10; 19(14):1711-47.
Biasi F, Leonarduzzi G, Oteiza PI, Poli G. PMID: 23305298; PMCID: PMC3809610.
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PubMed Mentions:
88 Fields:
Translation:
HumansAnimalsCells
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Decreased zinc availability affects glutathione metabolism in neuronal cells and in the developing brain. Toxicol Sci. 2013 May; 133(1):90-100.
Omata Y, Salvador GA, Supasai S, Keenan AH, Oteiza PI. PMID: 23377617; PMCID: PMC3627551.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Bioavailability of intact proanthocyanidins in the rat colon after ingestion of grape seed extract. J Agric Food Chem. 2013 Jan 09; 61(1):121-7.
Choy YY, Jaggers GK, Oteiza PI, Waterhouse AL. PMID: 23244439.
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PubMed Mentions:
28 Fields:
Translation:
Animals
-
The anthocyanin metabolites gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde decrease human colon cancer cell viability by regulating pro-oncogenic signals. Mol Carcinog. 2014 Jun; 53(6):432-9.
Forester SC, Choy YY, Waterhouse AL, Oteiza PI. PMID: 23124926.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Blood pressure-lowering effect of dietary (-)-epicatechin administration in L-NAME-treated rats is associated with restored nitric oxide levels. Free Radic Biol Med. 2012 Nov 15; 53(10):1894-902.
Litterio MC, Jaggers G, Sagdicoglu Celep G, Adamo AM, Costa MA, Oteiza PI, Fraga CG, Galleano M. PMID: 22985936.
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PubMed Mentions:
15 Fields:
Translation:
Animals
-
Zinc and the modulation of redox homeostasis. Free Radic Biol Med. 2012 Nov 01; 53(9):1748-59.
Oteiza PI. PMID: 22960578; PMCID: PMC3506432.
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PubMed Mentions:
116 Fields:
Translation:
HumansAnimalsCells
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Flavonoids and metabolic syndrome. Ann N Y Acad Sci. 2012 Jul; 1259:87-94.
Galleano M, Calabro V, Prince PD, Litterio MC, Piotrkowski B, Vazquez-Prieto MA, Miatello RM, Oteiza PI, Fraga CG. PMID: 22758640.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimals
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(-)-Epicatechin prevents TNFα-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes. Arch Biochem Biophys. 2012 Nov 15; 527(2):113-8.
Vazquez-Prieto MA, Bettaieb A, Haj FG, Fraga CG, Oteiza PI. PMID: 22425757; PMCID: PMC3992864.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Large procyanidins prevent bile-acid-induced oxidant production and membrane-initiated ERK1/2, p38, and Akt activation in Caco-2 cells. Free Radic Biol Med. 2012 Jan 01; 52(1):151-9.
Da Silva M, Jaggers GK, Verstraeten SV, Erlejman AG, Fraga CG, Oteiza PI. PMID: 22074817.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Aldosterone increases kidney tubule cell oxidants through calcium-mediated activation of NADPH oxidase and nitric oxide synthase. Free Radic Biol Med. 2011 Dec 01; 51(11):1996-2006.
Queisser N, Schupp N, Stopper H, Schinzel R, Oteiza PI. PMID: 21946068.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Dietary flavonoids: Role of (-)-epicatechin and related procyanidins in cell signaling. Free Radic Biol Med. 2011 Aug 15; 51(4):813-23.
Fraga CG, Oteiza PI. PMID: 21699974.
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PubMed Mentions:
70 Fields:
Translation:
HumansAnimalsCells
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A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain. Free Radic Biol Med. 2011 Jul 15; 51(2):480-9.
Mackenzie GG, Salvador GA, Romero C, Keen CL, Oteiza PI. PMID: 21600978; PMCID: PMC3506427.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Aldosterone induces oxidative stress, oxidative DNA damage and NF-κB-activation in kidney tubule cells. Mol Carcinog. 2011 Feb; 50(2):123-35.
Queisser N, Oteiza PI, Stopper H, Oli RG, Schupp N. PMID: 21229609.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cells. Neurotoxicology. 2011 Jan; 32(1):75-82.
Salvador GA, Oteiza PI. PMID: 21130806.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Basic biochemical mechanisms behind the health benefits of polyphenols. Mol Aspects Med. 2010 Dec; 31(6):435-45.
Fraga CG, Galleano M, Verstraeten SV, Oteiza PI. PMID: 20854840.
View in:
PubMed Mentions:
156 Fields:
Translation:
Humans
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The plasma membrane plays a central role in cells response to mechanical stress. Biochim Biophys Acta. 2010 Sep; 1798(9):1739-49.
Verstraeten SV, Mackenzie GG, Oteiza PI. PMID: 20599684.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Antioxidant actions of flavonoids: thermodynamic and kinetic analysis. Arch Biochem Biophys. 2010 Sep 01; 501(1):23-30.
Galleano M, Verstraeten SV, Oteiza PI, Fraga CG. PMID: 20388486.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Low extracellular zinc increases neuronal oxidant production through nadph oxidase and nitric oxide synthase activation. Free Radic Biol Med. 2010 Jun 15; 48(12):1577-87.
Aimo L, Cherr GN, Oteiza PI. PMID: 20211250; PMCID: PMC3506424.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Zinc deficiency and neurodevelopment: the case of neurons. Biofactors. 2010 Mar-Apr; 36(2):117-24.
Adamo AM, Oteiza PI. PMID: 20333753; PMCID: PMC3506421.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Trace elements in physiology and pathology. Biofactors. 2010 Mar-Apr; 36(2):87.
Oteiza PI. PMID: 20232347.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-κB and NFAT in fetal brain. J Nutr Biochem. 2010 Nov; 21(11):1069-75.
Aimo L, Mackenzie GG, Keenan AH, Oteiza PI. PMID: 20092996; PMCID: PMC3506428.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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The role of zinc in the modulation of neuronal proliferation and apoptosis. Neurotox Res. 2010 Jan; 17(1):1-14.
Adamo AM, Zago MP, Mackenzie GG, Aimo L, Keen CL, Keenan A, Oteiza PI. PMID: 19784710; PMCID: PMC2797425.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Cocoa, chocolate, and cardiovascular disease. J Cardiovasc Pharmacol. 2009 Dec; 54(6):483-90.
Galleano M, Oteiza PI, Fraga CG. PMID: 19701098; PMCID: PMC2797556.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimals
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Dimeric procyanidins are inhibitors of NF-kappaB-DNA binding. Biochem Pharmacol. 2009 Nov 01; 78(9):1252-62.
Mackenzie GG, Delfino JM, Keen CL, Fraga CG, Oteiza PI. PMID: 19591805.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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(-)-Epicatechin and related procyanidins modulate intracellular calcium and prevent oxidation in Jurkat T cells. Free Radic Res. 2008 Oct; 42(10):864-72.
Verstraeten SV, Mackenzie GG, Oteiza PI, Fraga CG. PMID: 18946795.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Aluminium and lead: molecular mechanisms of brain toxicity. Arch Toxicol. 2008 Nov; 82(11):789-802.
Verstraeten SV, Aimo L, Oteiza PI. PMID: 18668223.
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PubMed Mentions:
90 Fields:
Translation:
HumansAnimalsCells
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Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. Int J Cancer. 2008 Jul 01; 123(1):56-65.
Mackenzie GG, Queisser N, Wolfson ML, Fraga CG, Adamo AM, Oteiza PI. PMID: 18386790.
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PubMed Mentions:
48 Fields:
Translation:
HumansCells
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TNFalpha-induced NF-kappaB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells. Arch Biochem Biophys. 2008 Aug 15; 476(2):186-95.
Erlejman AG, Jaggers G, Fraga CG, Oteiza PI. PMID: 18275839.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations. Biochem Pharmacol. 2008 Apr 01; 75(7):1461-71.
Mackenzie GG, Adamo AM, Decker NP, Oteiza PI. PMID: 18275936.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Zinc deficiency in neuronal biology. IUBMB Life. 2007 Apr-May; 59(4-5):299-307.
Mackenzie GG, Zago MP, Aimo L, Oteiza PI. PMID: 17505969.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Zinc and the cytoskeleton in the neuronal modulation of transcription factor NFAT. J Cell Physiol. 2007 Jan; 210(1):246-56.
Mackenzie GG, Oteiza PI. PMID: 17044076.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Modulation of transcription factor NF-kappaB in Hodgkin's lymphoma cell lines: effect of (-)-epicatechin. Free Radic Res. 2006 Oct; 40(10):1086-94.
Mackenzie GG, Oteiza PI. PMID: 17015253.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct; 99(2):402-15.
Mackenzie GG, Keen CL, Oteiza PI. PMID: 17029595.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Procyanidins protect Caco-2 cells from bile acid- and oxidant-induced damage. Free Radic Biol Med. 2006 Oct 15; 41(8):1247-56.
Erlejman AG, Fraga CG, Oteiza PI. PMID: 17015171.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Zinc deficiency increases the susceptibility of human neuroblastoma cells to lead-induced activator protein-1 activation. Toxicol Sci. 2006 May; 91(1):184-91.
Aimo L, Oteiza PI. PMID: 16484283.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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alpha-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kappaB and AP-1 transcription factors in human neuroblastoma IMR-32 cells. Free Radic Res. 2006 Jan; 40(1):75-84.
Mackenzie GG, Zago MP, Erlejman AG, Aimo L, Keen CL, Oteiza PI. PMID: 16298762.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: role of H(2)O(2). Antioxid Redox Signal. 2005 Nov-Dec; 7(11-12):1773-82.
Zago MP, Mackenzie GG, Adamo AM, Keen CL, Oteiza PI. PMID: 16356139.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Trace elements and human health. Mol Aspects Med. 2005 Aug-Oct; 26(4-5):233-4.
Fraga CG, Oteiza PI, Keen CL. PMID: 16122783.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Zinc, oxidant-triggered cell signaling, and human health. Mol Aspects Med. 2005 Aug-Oct; 26(4-5):245-55.
Oteiza PI, Mackenzie GG. PMID: 16115673.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Antioxidant and membrane effects of procyanidin dimers and trimers isolated from peanut and cocoa. J Agric Food Chem. 2005 Jun 15; 53(12):5041-8.
Verstraeten SV, Hammerstone JF, Keen CL, Fraga CG, Oteiza PI. PMID: 15941354.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Vitamin A deficiency induces prooxidant environment and inflammation in rat aorta. Free Radic Res. 2005 Jun; 39(6):621-8.
Gatica L, Alvarez S, Gomez N, Zago MP, Oteiza P, Oliveros L, Gimenez MS. PMID: 16036340.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Relevance of lipid polar headgroups on boron-mediated changes in membrane physical properties. Arch Biochem Biophys. 2005 Jun 01; 438(1):103-10.
Verstraeten SV, Lanoue L, Keen CL, Oteiza PI. PMID: 15882836.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Flavonoid-membrane interactions: a protective role of flavonoids at the membrane surface? Clin Dev Immunol. 2005 Mar; 12(1):19-25.
Oteiza PI, Erlejman AG, Verstraeten SV, Keen CL, Fraga CG. PMID: 15712595; PMCID: PMC2270717.
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PubMed Mentions:
66 Fields:
Translation:
Cells
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Cocoa antioxidants and cardiovascular health. Am J Clin Nutr. 2005 01; 81(1 Suppl):298S-303S.
Keen CL, Holt RR, Oteiza PI, Fraga CG, Schmitz HH. PMID: 15640494.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Influence of zinc deficiency on cell-membrane fluidity in Jurkat, 3T3 and IMR-32 cells. Biochem J. 2004 Mar 01; 378(Pt 2):579-87.
Verstraeten SV, Zago MP, MacKenzie GG, Keen CL, Oteiza PI. PMID: 14629198; PMCID: PMC1223981.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Metals in neurodegeneration: involvement of oxidants and oxidant-sensitive transcription factors. Mol Aspects Med. 2004 Feb-Apr; 25(1-2):103-15.
Oteiza PI, Mackenzie GG, Verstraeten SV. PMID: 15051320.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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Membrane effects of cocoa procyanidins in liposomes and Jurkat T cells. Biol Res. 2004; 37(2):293-300.
Verstraeten SV, Oteiza PI, Fraga CG. PMID: 15455659.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells. FASEB J. 2004 Jan; 18(1):167-9.
Mackenzie GG, Carrasquedo F, Delfino JM, Keen CL, Fraga CG, Oteiza PI. PMID: 14630700.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications. J Nutr. 2003 05; 133(5 Suppl 2):1597S-1605S.
Keen CL, Clegg MS, Hanna LA, Lanoue L, Rogers JM, Daston GP, Oteiza P, Uriu-Adams JY. PMID: 12730474.
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PubMed Mentions:
36 Fields:
Translation:
Humans
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Flavan-3-ols and procyanidins protect liposomes against lipid oxidation and disruption of the bilayer structure. Free Radic Biol Med. 2003 Jan 01; 34(1):84-92.
Verstraeten SV, Keen CL, Schmitz HH, Fraga CG, Oteiza PI. PMID: 12498983.
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PubMed Mentions:
27 Fields:
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Al(3+)-mediated changes on membrane fluidity affects the activity of PI-PLC but not of PLC. Chem Phys Lipids. 2003 Jan; 122(1-2):159-63.
Verstraeten SV, Villaverde MS, Oteiza PI. PMID: 12598047.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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The oxidant defense system in human neuroblastoma IMR-32 cells predifferentiation and postdifferentiation to neuronal phenotypes. Neurochem Res. 2002 Nov; 27(11):1499-506.
Erlejman AG, Oteiza PI. PMID: 12512954.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Low intracellular zinc impairs the translocation of activated NF-kappa B to the nuclei in human neuroblastoma IMR-32 cells. J Biol Chem. 2002 Sep 13; 277(37):34610-7.
Mackenzie GG, Zago MP, Keen CL, Oteiza PI. PMID: 12089148.
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PubMed Mentions:
23 Fields:
Translation:
Humans
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Comparative study on the antioxidant capacity of wines and other plant-derived beverages. Ann N Y Acad Sci. 2002 May; 957:279-83.
Actis-Goretta L, Mackenzie GG, Oteiza PI, Fraga CG. PMID: 12074981.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Aluminum affects membrane physical properties in human neuroblastoma (IMR-32) cells both before and after differentiation. Arch Biochem Biophys. 2002 Mar 15; 399(2):167-73.
Verstraeten SV, Erlejman AG, Zago MP, Oteiza PI. PMID: 11888202.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Zinc status of human IMR-32 neuroblastoma cells influences their susceptibility to iron-induced oxidative stress. Dev Neurosci. 2002; 24(2-3):125-33.
Mackenzie GG, Keen CL, Oteiza PI. PMID: 12401950.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells