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Patricia Oteiza

TitlePROF-FY
InstitutionUniversity of California Davis
DepartmentNUTRITION
Address3109 Meyer Hall
CA 95616
Phone530-754-6074
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fraga CG, Oteiza P. Bioactives and their impact on human health. Mol Aspects Med. 2018 Jun; 61:1. PMID: 29907195.
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    2. Oteiza P, Heiss C. Introduction to special issue on Polyphenols and Health. Arch Biochem Biophys. 2018 May 31; 652:1-2. PMID: 29860030.
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    3. Daveri E, Cremonini E, Mastaloudis A, Hester SN, Wood SM, Waterhouse AL, Anderson M, Fraga CG, Oteiza P. Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice. Redox Biol. 2018 May 30; 18:16-24. PMID: 29890336.
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    4. Cremonini E, Oteiza P. (-)-Epicatechin and its metabolites prevent palmitate-induced NADPH oxidase upregulation, oxidative stress and insulin resistance in HepG2 cells. Arch Biochem Biophys. 2018 May 15; 646:55-63. PMID: 29608879.
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    5. Fraga CG, Oteiza P, Galleano M. Plant bioactives and redox signaling: (-)-Epicatechin as a paradigm. Mol Aspects Med. 2018 Feb 10. PMID: 29421170.
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    6. Oteiza P, Fraga CG, Mills DA, Taft DH. Flavonoids and the gastrointestinal tract: Local and systemic effects. Mol Aspects Med. 2018 Jun; 61:41-49. PMID: 29317252.
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    7. Cremonini E, Wang Z, Bettaieb A, Adamo AM, Daveri E, Mills DA, Kalanetra KM, Haj FG, Karakas S, Oteiza P. (-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance. Redox Biol. 2018 Apr; 14:588-599. PMID: 29154190.
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    8. Cremonini E, Mastaloudis A, Hester SN, Verstraeten SV, Anderson M, Wood SM, Waterhouse AL, Fraga CG, Oteiza P. Anthocyanins inhibit tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity. Food Funct. 2017 Aug 01; 8(8):2915-2923. PMID: 28740990.
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    9. Nuttall JR, Kucera HR, Supasai S, Gaikwad NW, Oteiza P. Combined Effects of Gestational Phthalate Exposure and Zinc Deficiency on Steroid Metabolism and Growth. Toxicol Sci. 2017 04 01; 156(2):469-479. PMID: 28115639.
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    10. Queisser N, Schupp N, Schwarz E, Hartmann C, Mackenzie GG, Oteiza P. Aldosterone activates the oncogenic signals ERK1/2 and STAT3 via redox-regulated mechanisms. Mol Carcinog. 2017 Aug; 56(8):1868-1883. PMID: 28272757.
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    11. Bettaieb A, Cremonini E, Kang H, Kang J, Haj FG, Oteiza P. Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice. Int J Biochem Cell Biol. 2016 Dec; 81(Pt B):383-392. PMID: 27592457.
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    12. Cremonini E, Bettaieb A, Haj FG, Fraga CG, Oteiza P. (-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice. Arch Biochem Biophys. 2016 06 01; 599:13-21. PMID: 26968772.
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    13. Choy YY, Fraga M, Mackenzie GG, Waterhouse AL, Cremonini E, Oteiza P. The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth. Mol Carcinog. 2016 12; 55(12):2196-2209. PMID: 26774105.
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    14. Huang YL, Supasai S, Kucera H, Gaikwad NW, Adamo AM, Mathieu P, Oteiza P. Nutritional marginal zinc deficiency disrupts placental 11ß-hydroxysteroid dehydrogenase type 2 modulation. Food Funct. 2016 Jan; 7(1):84-92. PMID: 26645329.
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    15. Prince PD, Lanzi CR, Toblli JE, Elesgaray R, Oteiza P, Fraga CG, Galleano M. Dietary (-)-epicatechin mitigates oxidative stress, NO metabolism alterations, and inflammation in renal cortex from fructose-fed rats. Free Radic Biol Med. 2016 Jan; 90:35-46. PMID: 26569027.
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    16. Nuttall JR, Supasai S, Kha J, Vaeth BM, Mackenzie GG, Adamo AM, Oteiza P. Gestational marginal zinc deficiency impaired fetal neural progenitor cell proliferation by disrupting the ERK1/2 signaling pathway. J Nutr Biochem. 2015 Nov; 26(11):1116-23. PMID: 26153680.
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    17. Litterio MC, Vazquez Prieto MA, Adamo AM, Elesgaray R, Oteiza P, Galleano M, Fraga CG. (-)-Epicatechin reduces blood pressure increase in high-fructose-fed rats: effects on the determinants of nitric oxide bioavailability. J Nutr Biochem. 2015 Jul; 26(7):745-51. PMID: 25943039.
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    18. Contreras TC, Ricciardi E, Cremonini E, Oteiza P. (-)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity. Arch Biochem Biophys. 2015 May 01; 573:84-91. PMID: 25795020.
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    19. Vazquez Prieto MA, Bettaieb A, Rodriguez Lanzi C, Soto VC, Perdicaro DJ, Galmarini CR, Haj FG, Miatello RM, Oteiza P. Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes. Mol Nutr Food Res. 2015 Apr; 59(4):622-33. PMID: 25620282; PMCID: PMC4408935.
    20. Fraga CG, Oteiza P. Flavanols and vascular health: molecular mechanisms to build evidence-based recommendations. Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S12. PMID: 26461285.
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    21. Verstraeten SV, Fraga CG, Oteiza P. Interactions of flavan-3-ols and procyanidins with membranes: mechanisms and the physiological relevance. Food Funct. 2015 Jan; 6(1):32-41. PMID: 25418533.
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    22. Bettaieb A, Vazquez Prieto MA, Rodriguez Lanzi C, Miatello RM, Haj FG, Fraga CG, Oteiza P. (-)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress. Free Radic Biol Med. 2014 Jul; 72:247-56. PMID: 24746618.
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    23. Queisser N, Oteiza P, Link S, Hey V, Stopper H, Schupp N. Aldosterone activates transcription factor Nrf2 in kidney cells both in vitro and in vivo. Antioxid Redox Signal. 2014 Nov 20; 21(15):2126-42. PMID: 24512358; PMCID: PMC4215337.
    24. Nuttall JR, Oteiza P. Zinc and the aging brain. Genes Nutr. 2014 Jan; 9(1):379. PMID: 24366781; PMCID: PMC3896632.
    25. Verstraeten SV, Jaggers GK, Fraga CG, Oteiza P. Procyanidins can interact with Caco-2 cell membrane lipid rafts: involvement of cholesterol. Biochim Biophys Acta. 2013 Nov; 1828(11):2646-53. PMID: 23899501.
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    26. Fraga CG, Oteiza P, Galleano M. In vitro measurements and interpretation of total antioxidant capacity. Biochim Biophys Acta. 2014 Feb; 1840(2):931-4. PMID: 23830861.
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    27. Omata Y, Salvador GA, Supasai S, Keenan AH, Oteiza P. Decreased zinc availability affects glutathione metabolism in neuronal cells and in the developing brain. Toxicol Sci. 2013 May; 133(1):90-100. PMID: 23377617; PMCID: PMC3627551.
    28. Choy YY, Jaggers GK, Oteiza P, Waterhouse AL. Bioavailability of intact proanthocyanidins in the rat colon after ingestion of grape seed extract. J Agric Food Chem. 2013 Jan 09; 61(1):121-7. PMID: 23244439.
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    29. Forester SC, Choy YY, Waterhouse AL, Oteiza P. The anthocyanin metabolites gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde decrease human colon cancer cell viability by regulating pro-oncogenic signals. Mol Carcinog. 2014 Jun; 53(6):432-9. PMID: 23124926.
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    30. Litterio MC, Jaggers G, Sagdicoglu Celep G, Adamo AM, Costa MA, Oteiza P, Fraga CG, Galleano M. Blood pressure-lowering effect of dietary (-)-epicatechin administration in L-NAME-treated rats is associated with restored nitric oxide levels. Free Radic Biol Med. 2012 Nov 15; 53(10):1894-902. PMID: 22985936.
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    31. Oteiza P. Zinc and the modulation of redox homeostasis. Free Radic Biol Med. 2012 Nov 01; 53(9):1748-59. PMID: 22960578; PMCID: PMC3506432.
    32. Galleano M, Calabro V, Prince PD, Litterio MC, Piotrkowski B, Vazquez-Prieto MA, Miatello RM, Oteiza P, Fraga CG. Flavonoids and metabolic syndrome. Ann N Y Acad Sci. 2012 Jul; 1259:87-94. PMID: 22758640.
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    33. Vazquez-Prieto MA, Bettaieb A, Haj FG, Fraga CG, Oteiza P. (-)-Epicatechin prevents TNFa-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes. Arch Biochem Biophys. 2012 Nov 15; 527(2):113-8. PMID: 22425757; PMCID: PMC3992864.
    34. Da Silva M, Jaggers GK, Verstraeten SV, Erlejman AG, Fraga CG, Oteiza P. Large procyanidins prevent bile-acid-induced oxidant production and membrane-initiated ERK1/2, p38, and Akt activation in Caco-2 cells. Free Radic Biol Med. 2012 Jan 01; 52(1):151-9. PMID: 22074817.
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    35. Queisser N, Schupp N, Stopper H, Schinzel R, Oteiza P. Aldosterone increases kidney tubule cell oxidants through calcium-mediated activation of NADPH oxidase and nitric oxide synthase. Free Radic Biol Med. 2011 Dec 01; 51(11):1996-2006. PMID: 21946068.
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    36. Fraga CG, Oteiza P. Dietary flavonoids: Role of (-)-epicatechin and related procyanidins in cell signaling. Free Radic Biol Med. 2011 Aug 15; 51(4):813-23. PMID: 21699974.
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    37. Mackenzie GG, Salvador GA, Romero C, Keen CL, Oteiza P. A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain. Free Radic Biol Med. 2011 Jul 15; 51(2):480-9. PMID: 21600978; PMCID: PMC3506427.
    38. Salvador GA, Oteiza P. Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cells. Neurotoxicology. 2011 Jan; 32(1):75-82. PMID: 21130806.
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    39. Fraga CG, Galleano M, Verstraeten SV, Oteiza P. Basic biochemical mechanisms behind the health benefits of polyphenols. Mol Aspects Med. 2010 Dec; 31(6):435-45. PMID: 20854840.
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    40. Verstraeten SV, Mackenzie GG, Oteiza P. The plasma membrane plays a central role in cells response to mechanical stress. Biochim Biophys Acta. 2010 Sep; 1798(9):1739-49. PMID: 20599684.
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    41. Galleano M, Verstraeten SV, Oteiza P, Fraga CG. Antioxidant actions of flavonoids: thermodynamic and kinetic analysis. Arch Biochem Biophys. 2010 Sep 01; 501(1):23-30. PMID: 20388486.
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    42. Aimo L, Cherr GN, Oteiza P. Low extracellular zinc increases neuronal oxidant production through nadph oxidase and nitric oxide synthase activation. Free Radic Biol Med. 2010 Jun 15; 48(12):1577-87. PMID: 20211250; PMCID: PMC3506424.
    43. Adamo AM, Oteiza P. Zinc deficiency and neurodevelopment: the case of neurons. Biofactors. 2010 Mar-Apr; 36(2):117-24. PMID: 20333753; PMCID: PMC3506421.
    44. Aimo L, Mackenzie GG, Keenan AH, Oteiza P. Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-?B and NFAT in fetal brain. J Nutr Biochem. 2010 Nov; 21(11):1069-75. PMID: 20092996; PMCID: PMC3506428.
    45. Adamo AM, Zago MP, Mackenzie GG, Aimo L, Keen CL, Keenan A, Oteiza P. The role of zinc in the modulation of neuronal proliferation and apoptosis. Neurotox Res. 2010 Jan; 17(1):1-14. PMID: 19784710.
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    46. Galleano M, Oteiza P, Fraga CG. Cocoa, chocolate, and cardiovascular disease. J Cardiovasc Pharmacol. 2009 Dec; 54(6):483-90. PMID: 19701098; PMCID: PMC2797556.
    47. Mackenzie GG, Delfino JM, Keen CL, Fraga CG, Oteiza P. Dimeric procyanidins are inhibitors of NF-kappaB-DNA binding. Biochem Pharmacol. 2009 Nov 01; 78(9):1252-62. PMID: 19591805.
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    48. Verstraeten SV, Mackenzie GG, Oteiza P, Fraga CG. (-)-Epicatechin and related procyanidins modulate intracellular calcium and prevent oxidation in Jurkat T cells. Free Radic Res. 2008 Oct; 42(10):864-72. PMID: 18946795.
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    49. Verstraeten SV, Aimo L, Oteiza P. Aluminium and lead: molecular mechanisms of brain toxicity. Arch Toxicol. 2008 Nov; 82(11):789-802. PMID: 18668223.
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    50. Mackenzie GG, Queisser N, Wolfson ML, Fraga CG, Adamo AM, Oteiza P. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. Int J Cancer. 2008 Jul 01; 123(1):56-65. PMID: 18386790.
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    51. Erlejman AG, Jaggers G, Fraga CG, Oteiza P. TNFalpha-induced NF-kappaB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells. Arch Biochem Biophys. 2008 Aug 15; 476(2):186-95. PMID: 18275839.
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    52. Mackenzie GG, Adamo AM, Decker NP, Oteiza P. Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations. Biochem Pharmacol. 2008 Apr 01; 75(7):1461-71. PMID: 18275936.
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    53. Mackenzie GG, Zago MP, Aimo L, Oteiza P. Zinc deficiency in neuronal biology. IUBMB Life. 2007 Apr-May; 59(4-5):299-307. PMID: 17505969.
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    54. Mackenzie GG, Oteiza P. Zinc and the cytoskeleton in the neuronal modulation of transcription factor NFAT. J Cell Physiol. 2007 Jan; 210(1):246-56. PMID: 17044076.
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    55. Mackenzie GG, Oteiza P. Modulation of transcription factor NF-kappaB in Hodgkin's lymphoma cell lines: effect of (-)-epicatechin. Free Radic Res. 2006 Oct; 40(10):1086-94. PMID: 17015253.
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    56. Mackenzie GG, Keen CL, Oteiza P. Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct; 99(2):402-15. PMID: 17029595.
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    57. Erlejman AG, Fraga CG, Oteiza P. Procyanidins protect Caco-2 cells from bile acid- and oxidant-induced damage. Free Radic Biol Med. 2006 Oct 15; 41(8):1247-56. PMID: 17015171.
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    58. Aimo L, Oteiza P. Zinc deficiency increases the susceptibility of human neuroblastoma cells to lead-induced activator protein-1 activation. Toxicol Sci. 2006 May; 91(1):184-91. PMID: 16484283.
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    59. Mackenzie GG, Zago MP, Erlejman AG, Aimo L, Keen CL, Oteiza P. alpha-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kappaB and AP-1 transcription factors in human neuroblastoma IMR-32 cells. Free Radic Res. 2006 Jan; 40(1):75-84. PMID: 16298762.
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    60. Zago MP, Mackenzie GG, Adamo AM, Keen CL, Oteiza P. Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: role of H(2)O(2). Antioxid Redox Signal. 2005 Nov-Dec; 7(11-12):1773-82. PMID: 16356139.
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    61. Fraga CG, Oteiza P, Keen CL. Trace elements and human health. Mol Aspects Med. 2005 Aug-Oct; 26(4-5):233-4. PMID: 16122783.
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    62. Oteiza P, Mackenzie GG. Zinc, oxidant-triggered cell signaling, and human health. Mol Aspects Med. 2005 Aug-Oct; 26(4-5):245-55. PMID: 16115673.
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    63. Verstraeten SV, Hammerstone JF, Keen CL, Fraga CG, Oteiza P. Antioxidant and membrane effects of procyanidin dimers and trimers isolated from peanut and cocoa. J Agric Food Chem. 2005 Jun 15; 53(12):5041-8. PMID: 15941354.
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    64. Gatica L, Alvarez S, Gomez N, Zago MP, Oteiza P, Oliveros L, Gimenez MS. Vitamin A deficiency induces prooxidant environment and inflammation in rat aorta. Free Radic Res. 2005 Jun; 39(6):621-8. PMID: 16036340.
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    65. Verstraeten SV, Lanoue L, Keen CL, Oteiza P. Relevance of lipid polar headgroups on boron-mediated changes in membrane physical properties. Arch Biochem Biophys. 2005 Jun 01; 438(1):103-10. PMID: 15882836.
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    66. Oteiza P, Erlejman AG, Verstraeten SV, Keen CL, Fraga CG. Flavonoid-membrane interactions: a protective role of flavonoids at the membrane surface? Clin Dev Immunol. 2005 Mar; 12(1):19-25. PMID: 15712595; PMCID: PMC2270717.
    67. Keen CL, Holt RR, Oteiza P, Fraga CG, Schmitz HH. Cocoa antioxidants and cardiovascular health. Am J Clin Nutr. 2005 01; 81(1 Suppl):298S-303S. PMID: 15640494.
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    68. Verstraeten SV, Zago MP, MacKenzie GG, Keen CL, Oteiza P. Influence of zinc deficiency on cell-membrane fluidity in Jurkat, 3T3 and IMR-32 cells. Biochem J. 2004 Mar 01; 378(Pt 2):579-87. PMID: 14629198; PMCID: PMC1223981.
    69. Oteiza P, Mackenzie GG, Verstraeten SV. Metals in neurodegeneration: involvement of oxidants and oxidant-sensitive transcription factors. Mol Aspects Med. 2004 Feb-Apr; 25(1-2):103-15. PMID: 15051320.
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    70. Verstraeten SV, Oteiza P, Fraga CG. Membrane effects of cocoa procyanidins in liposomes and Jurkat T cells. Biol Res. 2004; 37(2):293-300. PMID: 15455659.
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    71. Mackenzie GG, Carrasquedo F, Delfino JM, Keen CL, Fraga CG, Oteiza P. Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells. FASEB J. 2004 Jan; 18(1):167-9. PMID: 14630700.
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    72. Keen CL, Clegg MS, Hanna LA, Lanoue L, Rogers JM, Daston GP, Oteiza P, Uriu-Adams JY. The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications. J Nutr. 2003 05; 133(5 Suppl 2):1597S-1605S. PMID: 12730474.
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    73. Verstraeten SV, Keen CL, Schmitz HH, Fraga CG, Oteiza P. Flavan-3-ols and procyanidins protect liposomes against lipid oxidation and disruption of the bilayer structure. Free Radic Biol Med. 2003 Jan 01; 34(1):84-92. PMID: 12498983.
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    74. Verstraeten SV, Villaverde MS, Oteiza P. Al(3+)-mediated changes on membrane fluidity affects the activity of PI-PLC but not of PLC. Chem Phys Lipids. 2003 Jan; 122(1-2):159-63. PMID: 12598047.
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    75. Verstraeten SV, Oteiza P. Al(3+)-mediated changes in membrane physical properties participate in the inhibition of polyphosphoinositide hydrolysis. Arch Biochem Biophys. 2002 Dec 15; 408(2):263-71. PMID: 12464280.
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    76. Erlejman AG, Oteiza P. The oxidant defense system in human neuroblastoma IMR-32 cells predifferentiation and postdifferentiation to neuronal phenotypes. Neurochem Res. 2002 Nov; 27(11):1499-506. PMID: 12512954.
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    77. Fraga CG, Oteiza P. Iron toxicity and antioxidant nutrients. Toxicology. 2002 Oct 30; 180(1):23-32. PMID: 12324197.
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    78. Mackenzie GG, Zago MP, Keen CL, Oteiza P. Low intracellular zinc impairs the translocation of activated NF-kappa B to the nuclei in human neuroblastoma IMR-32 cells. J Biol Chem. 2002 Sep 13; 277(37):34610-7. PMID: 12089148.
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    79. Actis-Goretta L, Mackenzie GG, Oteiza P, Fraga CG. Comparative study on the antioxidant capacity of wines and other plant-derived beverages. Ann N Y Acad Sci. 2002 May; 957:279-83. PMID: 12074981.
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    80. Verstraeten SV, Erlejman AG, Zago MP, Oteiza P. Aluminum affects membrane physical properties in human neuroblastoma (IMR-32) cells both before and after differentiation. Arch Biochem Biophys. 2002 Mar 15; 399(2):167-73. PMID: 11888202.
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    81. Mackenzie GG, Keen CL, Oteiza P. Zinc status of human IMR-32 neuroblastoma cells influences their susceptibility to iron-induced oxidative stress. Dev Neurosci. 2002; 24(2-3):125-33. PMID: 12401950.
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