Hsing-Jien Kung

Title(s)Professor, Biochemistry and Molecular Medicine
SchoolSchool of Medicine
AddressResearch III Bldg/UCDMC
CA 95817
Phone916-734-1538
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    Collapse Research 
    Collapse Research Activities and Funding
    Androgen Signaling and Coactivator Regulation in PCA
    NIH R01CA150197Apr 1, 2010 - Jan 31, 2016
    Role: Principal Investigator
    Modeling androgen receptor in prostate cells
    NIH R01DK078243Aug 1, 2007 - Jul 31, 2012
    Role: Principal Investigator
    Androgen signaling and kinase regulation in PCA
    NIH R01CA114575Jun 1, 2005 - Apr 30, 2011
    Role: Principal Investigator
    K-bZIP and Transcriptional Regulation of KSHV
    NIH R01CA111185Sep 1, 2004 - Jun 30, 2010
    Role: Principal Investigator
    Training Program in Oncogenic Signals and Chromosome Biology
    NIH T32CA108459Jul 1, 2004 - Aug 31, 2021
    Role: Co-Principal Investigator
    TRANSCRIPTIONAL TRANSACTIVATION OF KSHV AND RRV
    NIH R01CA091574Jan 25, 2001 - Dec 31, 2004
    Role: Principal Investigator
    RESTRICTION BASED ANALYSIS OF GENE EXPRESSION (RAGE)
    NIH R01CA082073Sep 30, 1998 - Jul 31, 2003
    Role: Principal Investigator
    Tyrosine Kinases and Prostate Cancer
    NIH R01CA165263Jul 24, 1997 - Mar 31, 2018
    Role: Principal Investigator
    Tyrosine Kinases and Prostate Cancer
    NIH R01DK052659Jul 24, 1997 - Mar 31, 2012
    Role: Principal Investigator
    ERBB KINASE ACTIVATION AND TRANSFORMATION
    NIH R37CA039207Jan 1, 1991 - Jan 31, 2000
    Role: Principal Investigator
    ONCOGENE ACTIVATION IN B AND T LYMPHOCYTES
    NIH R37CA046613Mar 1, 1988 - Aug 31, 2002
    Role: Principal Investigator
    ONCOGENE ACTIVATION IN AVIAN B &T LYMPHOMA
    NIH R01CA046613Mar 1, 1988 - Feb 28, 1993
    Role: Principal Investigator
    ONCOGENE AND ACTIVATOR: TUMORIGENESIS BY CLONED DNA
    NIH R01CA038659Jan 1, 1985 - Dec 31, 1987
    Role: Principal Investigator
    ERBB KINASE ACTIVATION AND TRANSFORMATION
    NIH R01CA039207Sep 1, 1984 - Dec 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Extracellular arginine availability modulates eIF2α O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis. J Biomed Sci. 2023 May 22; 30(1):32. Hung YW, Ouyang C, Ping X, Qi Y, Wang YC, Kung HJ, Ann DK. PMID: 37217939; PMCID: PMC10201738.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination. Cell Rep. 2023 Mar 23; 42(4):112296. Wang YC, Kelso AA, Karamafrooz A, Chen YH, Chen WK, Cheng CT, Qi Y, Gu L, Malkas L, Taglialatela A, Kung HJ, Moldovan GL, Ciccia A, Stark JM, Ann DK. PMID: 36961817.
      View in: PubMed   Mentions:    Fields:    
    3. Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer. EBioMedicine. 2023 Apr; 90:104500. Hung CL, Liu HH, Fu CW, Yeh HH, Hu TL, Kuo ZK, Lin YC, Jhang MR, Hwang CS, Hsu HC, Kung HJ, Wang LY. PMID: 36893587; PMCID: PMC10011747.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination. bioRxiv. 2023 Feb 03. Wang YC, Kelso AA, Karamafrooz A, Chen YH, Chen WK, Cheng CT, Qi Y, Gu L, Malkas L, Kung HJ, Moldovan GL, Ciccia A, Stark JM, Ann DK. PMID: 36778247; PMCID: PMC9915598.
      View in: PubMed   Mentions:
    5. Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer. J Biomed Sci. 2022 May 09; 29(1):29. Liu JS, Fang WK, Yang SM, Wu MC, Chen TJ, Chen CM, Lin TY, Liu KL, Wu CM, Chen YC, Chuu CP, Wang LY, Hsieh HP, Kung HJ, Wang WC. PMID: 35534851; PMCID: PMC9082844.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. TEAD4 as an Oncogene and a Mitochondrial Modulator. Front Cell Dev Biol. 2022; 10:890419. Hsu SC, Lin CY, Lin YY, Collins CC, Chen CL, Kung HJ. PMID: 35602596; PMCID: PMC9117765.
      View in: PubMed   Mentions: 1  
    7. Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion. Nat Commun. 2022 03 21; 13(1):1511. Jiang N, Xie B, Xiao W, Fan M, Xu S, Duan Y, Hamsafar Y, Evans AC, Huang J, Zhou W, Lin X, Ye N, Wanggou S, Chen W, Jing D, Fragoso RC, Dugger BN, Wilson PF, Coleman MA, Xia S, Li X, Sun LQ, Monjazeb AM, Wang A, Murphy WJ, Kung HJ, Lam KS, Chen HW, Li JJ. PMID: 35314680; PMCID: PMC8938495.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    8. Inhibition of KDM4C/c-Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism. Clin Transl Med. 2022 03; 12(3):e764. Lin CY, Wang BJ, Fu YK, Huo C, Wang YP, Chen BC, Liu WY, Tseng JC, Jiang SS, Sie ZL, Tsai KK, Yuh CH, Wang WC, Kung HJ, Chuu CP. PMID: 35343073; PMCID: PMC8958350.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    9. Targeting Mitochondrial OXPHOS and Their Regulatory Signals in Prostate Cancers. Int J Mol Sci. 2021 Dec 14; 22(24). Chen CL, Lin CY, Kung HJ. PMID: 34948229; PMCID: PMC8708687.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    10. Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging. Biomedicines. 2021 Nov 07; 9(11). Chao CC, Shen PW, Tzeng TY, Kung HJ, Tsai TF, Wong YH. PMID: 34829864; PMCID: PMC8615703.
      View in: PubMed   Mentions: 2  
    11. Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance. Acta Pharm Sin B. 2022 Apr; 12(4):1871-1884. Wang H, Wang Q, Cai G, Duan Z, Nugent Z, Huang J, Zheng J, Borowsky AD, Li JJ, Liu P, Kung HJ, Murphy L, Chen HW, Wang J. PMID: 35847493; PMCID: PMC9279715.
      View in: PubMed   Mentions: 2  
    12. Prognostic Significance of O-GlcNAc and PKM2 in Hormone Receptor-Positive and HER2-Nonenriched Breast Cancer. Diagnostics (Basel). 2021 Aug 12; 11(8). Kuo WL, Tseng LL, Chang CC, Chen CJ, Cheng ML, Cheng HH, Wu MJ, Chen YL, Chang RT, Tang HY, Hsu YC, Lin WJ, Kao CY, Hsieh WP, Kung HJ, Wang WC. PMID: 34441396; PMCID: PMC8392504.
      View in: PubMed   Mentions: 2  
    13. Arginine Signaling and Cancer Metabolism. Cancers (Basel). 2021 Jul 15; 13(14). Chen CL, Hsu SC, Ann DK, Yen Y, Kung HJ. PMID: 34298755; PMCID: PMC8306961.
      View in: PubMed   Mentions: 53  
    14. Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer. Theranostics. 2021; 11(16):7779-7796. Wu MJ, Chen CJ, Lin TY, Liu YY, Tseng LL, Cheng ML, Chuu CP, Tsai HK, Kuo WL, Kung HJ, Wang WC. PMID: 34335964; PMCID: PMC8315051.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    15. Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic silencing of metabolic and DNA-repair genes. Theranostics. 2021; 11(15):7527-7545. Hsu SC, Chen CL, Cheng ML, Chu CY, Changou CA, Yu YL, Yeh SD, Kuo TC, Kuo CC, Chuu CP, Li CF, Wang LH, Chen HW, Yen Y, Ann DK, Wang HJ, Kung HJ. PMID: 34158865; PMCID: PMC8210599.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    16. Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises. Int J Mol Sci. 2021 May 05; 22(9). Lei CS, Kung HJ, Shih JW. PMID: 34063159; PMCID: PMC8124393.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    17. Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells. Nat Commun. 2021 04 23; 12(1):2398. Chen CL, Hsu SC, Chung TY, Chu CY, Wang HJ, Hsiao PW, Yeh SD, Ann DK, Yen Y, Kung HJ. PMID: 33893278; PMCID: PMC8065123.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    18. Genome-wide CRISPR/Cas9 knockout screening uncovers a novel inflammatory pathway critical for resistance to arginine-deprivation therapy. Theranostics. 2021; 11(8):3624-3641. Chu CY, Lee YC, Hsieh CH, Yeh CT, Chao TY, Chen PH, Lin IH, Hsieh TH, Shih JW, Cheng CH, Chang CC, Lin PS, Huang YL, Chen TM, Yen Y, Ann DK, Kung HJ. PMID: 33664852; PMCID: PMC7914361.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    19. Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer. Proc Natl Acad Sci U S A. 2020 10 06; 117(40):24859-24866. Tseng LL, Cheng HH, Yeh TS, Huang SC, Syu YY, Chuu CP, Yuh CH, Kung HJ, Wang WC. PMID: 32958674; PMCID: PMC7547212.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    20. Signaling in and out: long-noncoding RNAs in tumor hypoxia. J Biomed Sci. 2020 May 05; 27(1):59. Kuo TC, Kung HJ, Shih JW. PMID: 32370770; PMCID: PMC7201962.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    21. Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs. Aging Cell. 2020 05; 19(5):e13107. Yang CP, Yang WS, Wong YH, Wang KH, Teng YC, Chang MH, Liao KH, Nian FS, Chao CC, Tsai JW, Hwang WL, Lin MW, Tzeng TY, Wang PN, Campbell M, Chen LK, Tsai TF, Chang PC, Kung HJ. PMID: 32233025; PMCID: PMC7253071.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    22. Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor. Mol Cell. 2020 01 16; 77(2):213-227.e5. Wu JY, Huang TW, Hsieh YT, Wang YF, Yen CC, Lee GL, Yeh CC, Peng YJ, Kuo YY, Wen HT, Lin HC, Hsiao CW, Wu KK, Kung HJ, Hsu YJ, Kuo CC. PMID: 31735641.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    23. Histone Demethylase KDM4C Stimulates the Proliferation of Prostate Cancer Cells via Activation of AKT and c-Myc. Cancers (Basel). 2019 Nov 13; 11(11). Lin CY, Wang BJ, Chen BC, Tseng JC, Jiang SS, Tsai KK, Shen YY, Yuh CH, Sie ZL, Wang WC, Kung HJ, Chuu CP. PMID: 31766290; PMCID: PMC6896035.
      View in: PubMed   Mentions: 13  
    24. RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat Commun. 2019 10 11; 10(1):4621. Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To KF, Kung HJ, Fiehn O, Zhao R, Evans RM, Chen HW. PMID: 31604910; PMCID: PMC6789042.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    25. Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis. EMBO Rep. 2019 10 04; 20(10):e45986. Wang YH, Huang JT, Chen WL, Wang RH, Kao MC, Pan YR, Chan SH, Tsai KW, Kung HJ, Lin KT, Wang LH. PMID: 31468690; PMCID: PMC6776913.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    26. Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. Commun Biol. 2019; 2:105. Chen TJ, Wang HJ, Liu JS, Cheng HH, Hsu SC, Wu MC, Lu CH, Wu YF, Wu JW, Liu YY, Kung HJ, Wang WC. PMID: 30911680; PMCID: PMC6420622.
      View in: PubMed   Mentions: 14  Translation:HumansCells
    27. Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. Commun Biol. 2019 Mar 15; 2(1):105. Chen TJ, Wang HJ, Liu JS, Cheng HH, Hsu SC, Wu MC, Lu CH, Wu YF, Wu JW, Liu YY, Kung HJ, Wang WC. PMID: 31924980.
      View in: PubMed   Mentions:
    28. KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis. Cell Death Dis. 2019 01 25; 10(2):68. Wu MC, Cheng HH, Yeh TS, Li YC, Chen TJ, Sit WY, Chuu CP, Kung HJ, Chien S, Wang WC. PMID: 30683841; PMCID: PMC6347645.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    29. Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction. Commun Biol. 2018; 1:178. Cheng CT, Qi Y, Wang YC, Chi KK, Chung Y, Ouyang C, Chen YR, Oh ME, Sheng X, Tang Y, Liu YR, Lin HH, Kuo CY, Schones D, Vidal CM, Chu JC, Wang HJ, Chen YH, Miller KM, Chu P, Yen Y, Jiang L, Kung HJ, Ann DK. PMID: 30393775; PMCID: PMC6203837.
      View in: PubMed   Mentions: 58  
    30. Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis. Autophagy. 2018; 14(9):1481-1498. Lin HH, Chung Y, Cheng CT, Ouyang C, Fu Y, Kuo CY, Chi KK, Sadeghi M, Chu P, Kung HJ, Li CF, Limesand KH, Ann DK. PMID: 29956571; PMCID: PMC6135591.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    31. KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC. Oncogene. 2019 01; 38(1):17-32. Wang HJ, Pochampalli M, Wang LY, Zou JX, Li PS, Hsu SC, Wang BJ, Huang SH, Yang P, Yang JC, Chu CY, Hsieh CL, Sung SY, Li CF, Tepper CG, Ann DK, Gao AC, Evans CP, Izumiya Y, Chuu CP, Wang WC, Chen HW, Kung HJ. PMID: 30072740; PMCID: PMC6755995.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    32. HOTAIR is a REST-regulated lncRNA that promotes neuroendocrine differentiation in castration resistant prostate cancer. Cancer Lett. 2018 10 01; 433:43-52. Chang YT, Lin TP, Tang JT, Campbell M, Luo YL, Lu SY, Yang CP, Cheng TY, Chang CH, Liu TT, Lin CH, Kung HJ, Pan CC, Chang PC. PMID: 29944905.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    33. Targeting Galectin-1 Impairs Castration-Resistant Prostate Cancer Progression and Invasion. Clin Cancer Res. 2018 09 01; 24(17):4319-4331. Shih TC, Liu R, Wu CT, Li X, Xiao W, Deng X, Kiss S, Wang T, Chen XJ, Carney R, Kung HJ, Duan Y, Ghosh PM, Lam KS. PMID: 29666302; PMCID: PMC6125207.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    34. In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity. J Vis Exp. 2018 01 29; (131). Yang WS, Campbell M, Kung HJ, Chang PC. PMID: 29443041; PMCID: PMC5912215.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    35. Long non-coding RNA and tumor hypoxia: new players ushered toward an old arena. J Biomed Sci. 2017 Aug 08; 24(1):53. Shih JW, Kung HJ. PMID: 28789687; PMCID: PMC5547530.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    36. EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis. Oncogene. 2017 11 23; 36(47):6542-6554. Shih CH, Chang YJ, Huang WC, Jang TH, Kung HJ, Wang WC, Yang MH, Lin MC, Huang SF, Chou SW, Chang E, Chiu H, Shieh TY, Chen YJ, Wang LH, Chen L. PMID: 28759046; PMCID: PMC5702718.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    37. Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression. Nat Commun. 2017 06 22; 8:15874. Shih JW, Chiang WF, Wu ATH, Wu MH, Wang LY, Yu YL, Hung YW, Wang WC, Chu CY, Hung CL, Changou CA, Yen Y, Kung HJ. PMID: 28639619; PMCID: PMC5489688.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimals
    38. ITK inhibition for the targeted treatment of CTCL. J Dermatol Sci. 2017 Jul; 87(1):88-91. Bustos-Villalobos I, Bergstrom JW, Haigh NE, Luna JI, Mitra A, Marusina AI, Merleev AA, Wang EA, Sukhov A, Sultani H, Liu R, Bhardwaj G, Guo W, Kung HJ, Lam KS, Maverakis E. PMID: 28434812; PMCID: PMC6459605.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    39. REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer. Sci Rep. 2017 03 03; 7:42795. Chang YT, Lin TP, Campbell M, Pan CC, Lee SH, Lee HC, Yang MH, Kung HJ, Chang PC. PMID: 28256535; PMCID: PMC5335619.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    40. KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis. Cell Rep. 2016 09 13; 16(11):3016-3027. Wang LY, Hung CL, Chen YR, Yang JC, Wang J, Campbell M, Izumiya Y, Chen HW, Wang WC, Ann DK, Kung HJ. PMID: 27626669; PMCID: PMC5024724.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    41. Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy. Cell Death Differ. 2016 11 01; 23(11):1886-1896. Wang J, Wang H, Wang LY, Cai D, Duan Z, Zhang Y, Chen P, Zou JX, Xu J, Chen X, Kung HJ, Chen HW. PMID: 27612013; PMCID: PMC5071577.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    42. Retraction: MMP-13 is involved in oral cancer cell metastasis. Oncotarget. 2016 07 26; 7(30):48851. Huang SH, Law CH, Kuo PH, Hu RY, Yang CC, Chung TW, Li JM, Lin LH, Liu YC, Liao EC, Tsai YT, Wei YS, Lin CC, Chang CW, Chou HC, Wang WC, Chang MD, Wang LH, Kung HJ, Chan HL, Lyu PC. PMID: 27885991; PMCID: PMC5217056.
      View in: PubMed   Mentions: 1     Fields:    
    43. Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells. Cancer Res. 2016 09 01; 76(17):5006-18. Cheng CT, Kuo CY, Ouyang C, Li CF, Chung Y, Chan DC, Kung HJ, Ann DK. PMID: 27364555; PMCID: PMC5316485.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    44. A viral kinase mimics S6 kinase to enhance cell proliferation. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7876-81. Bhatt AP, Wong JP, Weinberg MS, Host KM, Giffin LC, Buijnink J, van Dijk E, Izumiya Y, Kung HJ, Temple BR, Damania B. PMID: 27342859; PMCID: PMC4948314.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    45. HIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity. Oncotarget. 2016 Jun 07; 7(23):34052-69. Kuo CY, Cheng CT, Hou P, Lin YP, Ma H, Chung Y, Chi K, Chen Y, Li W, Kung HJ, Ann DK. PMID: 27058900; PMCID: PMC5085137.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    46. Corrigendum: ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat Med. 2016 06 07; 22(6):692. Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. PMID: 27270780.
      View in: PubMed   Mentions: 4     Fields:    
    47. Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes. Cancer Lett. 2016 08 10; 378(2):69-79. Wang J, Duan Z, Nugent Z, Zou JX, Borowsky AD, Zhang Y, Tepper CG, Li JJ, Fiehn O, Xu J, Kung HJ, Murphy LC, Chen HW. PMID: 27164560; PMCID: PMC7505026.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    48. REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling. Oncotarget. 2016 May 03; 7(18):26137-51. Lin TP, Chang YT, Lee SY, Campbell M, Wang TC, Shen SH, Chung HJ, Chang YH, Chiu AW, Pan CC, Lin CH, Chu CY, Kung HJ, Cheng CY, Chang PC. PMID: 27034167; PMCID: PMC5041970.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    49. Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening. ACS Comb Sci. 2016 06 13; 18(6):320-9. Wu CY, Wang DH, Wang X, Dixon SM, Meng L, Ahadi S, Enter DH, Chen CY, Kato J, Leon LJ, Ramirez LM, Maeda Y, Reis CF, Ribeiro B, Weems B, Kung HJ, Lam KS. PMID: 27053324; PMCID: PMC4908505.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    50. MMP-13 is involved in oral cancer cell metastasis. Oncotarget. 2016 03 29; 7(13):17144-61. Huang SH, Law CH, Kuo PH, Hu RY, Yang CC, Chung TW, Li JM, Lin LH, Liu YC, Liao EC, Tsai YT, Wei YS, Lin CC, Chang CW, Chou HC, Wang WC, Chang MD, Wang LH, Kung HJ, Chan HL, Lyu PC. PMID: 26958809; PMCID: PMC4941377.
      View in: PubMed   Mentions: 12     Fields:    
    51. ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat Med. 2016 05; 22(5):488-96. Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. PMID: 27019329; PMCID: PMC5030109.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
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    189. Identification of protein kinases dysregulated in CD4(+) T cells in pathogenic versus apathogenic simian immunodeficiency virus infection. J Virol. 2001 Dec; 75(23):11298-306. Bostik P, Wu P, Dodd GL, Villinger F, Mayne AE, Bostik V, Grimm BD, Robinson D, Kung HJ, Ansari AA. PMID: 11689610; PMCID: PMC114715.
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    298. c-erbB activation in avian leukosis virus-induced erythroblastosis: clustered integration sites and the arrangement of provirus in the c-erbB alleles. Proc Natl Acad Sci U S A. 1985 Apr; 82(8):2287-91. Raines MA, Lewis WG, Crittenden LB, Kung HJ. PMID: 2986110; PMCID: PMC397542.
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    299. Isolation and structural mapping of a human c-src gene homologous to the transforming gene (v-src) of Rous sarcoma virus. J Virol. 1985 Jan; 53(1):19-24. Gibbs CP, Tanaka A, Anderson SK, Radul J, Baar J, Ridgway A, Kung HJ, Fujita DJ. PMID: 2981336; PMCID: PMC254972.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    300. Extensive homology exists between Marek disease herpesvirus and its vaccine virus, herpesvirus of turkeys. Proc Natl Acad Sci U S A. 1984 Jun; 81(11):3365-9. Gibbs CP, Nazerian K, Velicer LF, Kung HJ. PMID: 6328512; PMCID: PMC345508.
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    301. Activation of the cellular oncogene c-erbB by LTR insertion: molecular basis for induction of erythroblastosis by avian leukosis virus. Cell. 1983 Jun; 33(2):357-68. Fung YK, Lewis WG, Crittenden LB, Kung HJ. PMID: 6305505.
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    302. Tumor induction by direct injection of cloned v-src DNA into chickens. Proc Natl Acad Sci U S A. 1983 Jan; 80(2):353-7. Fung YK, Crittenden LB, Fadly AM, Kung HJ. PMID: 6300833; PMCID: PMC393375.
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    303. Orientation and position of avian leukosis virus DNA relative to the cellular oncogene c-myc in B-lymphoma tumors of highly susceptible 15I5 X 7(2) chickens. J Virol. 1982 Nov; 44(2):742-6. Fung YK, Crittenden LB, Kung HJ. PMID: 6292531; PMCID: PMC256323.
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    304. Avian lymphoid leukosis virus infection and DNA integration in the preleukotic bursal tissues: a comparative study of susceptible and resistant lines. Virology. 1982 Jun; 119(2):411-21. Fung YK, Fadly AM, Crittenden LB, Kung HJ. PMID: 6281983.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    305. An IgM-producing B lymphoblastoid cell line established from lymphomas induced by a non-defective reticuloendotheliosis virus. J Gen Virol. 1982 Feb; 58(Pt 2):351-60. Nazerian K, Witter RL, Crittenden LB, Noori-Dalloii MR, Kung HJ. PMID: 6278061.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    306. Specific integration of REV proviruses in avian bursal lymphomas. Nature. 1981 Dec 10; 294(5841):574-6. Noori-Daloii MR, Swift RA, Kung HJ, Crittenden LB, Witter RL. PMID: 6273749.
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    307. On the mechanism of retrovirus-induced avian lymphoid leukosis: deletion and integration of the proviruses. Proc Natl Acad Sci U S A. 1981 Jun; 78(6):3418-22. Fung YK, Fadly AM, Crittenden LB, Kung HJ. PMID: 6267589; PMCID: PMC319579.
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    308. Synthesis of plus strands of retroviral DNA in cells infected with avian sarcoma virus and mouse mammary tumor virus. J Virol. 1981 Jan; 37(1):127-38. Kung HJ, Fung YK, Majors JE, Bishop JM, Varmus HE. PMID: 6260968; PMCID: PMC170989.
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    309. The molecular basis of avian retrovirus-induced leukemogenesis. Haematol Blood Transfus. 1981; 26:445-51. Kung HJ, Fung YK, Crittenden LC, Fadly A, Dube SK. PMID: 6274758.
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    310. Identification and characterization of dimeric and trimeric circular forms of avian sarcoma virus-specific DNA. Virology. 1980 Jun; 103(2):425-33. Kung HJ, Shank PR, Bishop JM, Varmus HE. PMID: 6247823.
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    311. Structures of unintegrated and integrated forms of the deoxyribonucleic acid of ribonucleic acid tumour viruses. Biochem Soc Symp. 1979; 44:103-18. Varmus HE, Shank PR, Hughes SH, Kung HJ, Heasley S, Majors J, Vogt PK, Bishop JM. PMID: 227397.
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    312. Synthesis, structure, and integration of the DNA of RNA tumor viruses. Cold Spring Harb Symp Quant Biol. 1979; 43 Pt 2:851-64. Varmus HE, Shank PR, Hughes SE, Kung HJ, Heasley S, Majors J, Vogt PK, Bishop JM. PMID: 90576.
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    313. Mapping unintegrated avian sarcoma virus DNA: termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA. Cell. 1978 Dec; 15(4):1383-95. Shank PR, Hughes SH, Kung HJ, Majors JE, Quintrell N, Guntaka RV, Bishop JM, Varmus HE. PMID: 215324.
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    314. Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell. 1978 Dec; 15(4):1397-410. Hughes SH, Shank PR, Spector DH, Kung HJ, Bishop JM, Varmus HE, Vogt PK, Breitman ML. PMID: 215325.
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    315. Kinetics of synthesis, structure and purification of avian sarcoma virus-specific DNA made in the cytoplasm of acutely infected cells. J Mol Biol. 1978 Mar 25; 120(1):55-82. Varmus HE, Heasley S, Kung HJ, Oppermann H, Smith VC, Bishop JM, Shank PR. PMID: 205652.
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    316. Characterization of DNA complementary to nucleotide sequences adjacent to poly(A) at the 3'-terminus of the avian sarcoma virus genome. Virology. 1977 Jun 01; 79(1):183-97. Tal J, Kung HJ, Varmus HE, Bishop JM. PMID: 194400.
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    317. Characterization of DNA complementary to nucleotide sequences at the 5'-terminus of the avian sarcoma virus genome. Virology. 1977 Jun 01; 79(1):198-215. Friedrich R, Kung HJ, Baker B, Varmus HE, Goodman HM, Bishop JM. PMID: 194401.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    318. Size, subunit composition, and secondary structure of the Friend virus genome. J Virol. 1976 Oct; 20(1):264-72. Dube S, Kung HJ, Bender W, Davidson N, Ostertag W. PMID: 978793; PMCID: PMC354987.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    319. Covalently closed circular DNA of avian sarcoma virus: purification from nuclei of infected quail tumor cells and measurement by electron microscopy and gel electrophoresis. J Mol Biol. 1976 Sep 15; 106(2):337-57. Guntaka RV, Richards OC, Shank PR, Kung HJ, Davidson N. PMID: 185393.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    320. RD-114, baboon, and woolly monkey viral RNA's compared in size and structure. Cell. 1976 Apr; 7(4):609-20. Kung HJ, Hu S, Bender W, Bailey JM, Davidson N, Nicolson MO, McAllister RM. PMID: 182377.
      View in: PubMed   Mentions: 59     Fields:    Translation:Cells
    321. Structure, subunit composition, and molecular weight of RD-114 RNA. J Virol. 1975 Aug; 16(2):397-411. Kung HJ, Bailey JM, Davidson N, Nicolson MO, McAllister RM. PMID: 168408; PMCID: PMC354678.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    322. Electron microscope studies of tumor virus RNA. Cold Spring Harb Symp Quant Biol. 1975; 39 Pt 2:827-34. Kung HJ, Bailey JM, Davidson N, Vogt PK, Nicolson MO, McAllister RM. PMID: 169036.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    323. Structure and molecular length of the large subunits of RD-114 viral RNA. J Virol. 1974 Jul; 14(1):170-3. Kung HJ, Bailey JM, Davidson N, Nicolson MO, McALLISTER RM. PMID: 4365329; PMCID: PMC355491.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    324. An electron microscope study of Sindbis virus RNA. Cold Spring Harb Symp Quant Biol. 1974; 38:943-50. Hsu MT, Kung HJ, Davidson N. PMID: 4598643.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
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