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Xinbin Chen, PhD

Title(s)Professor, School of Veterinary Medicine
SchoolUniversity of California, Davis
Address2128A Tupper Hall
CA 95616
Phone530-754-8404
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    1. Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1. Proc Natl Acad Sci U S A. 2019 11 26; 116(48):24259-24267. Zhang J, Sun W, Kong X, Zhang Y, Yang HJ, Ren C, Jiang Y, Chen M, Chen X. PMID: 31712410.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. ROR? is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat Commun. 2019 10 11; 10(1):4621. Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To KF, Kung HJ, Fiehn O, Zhao R, Evans RM, Chen HW. PMID: 31604910.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis. Oncogene. 2019 08; 38(35):6256-6269. Zhang Y, Feng X, Zhang J, Chen M, Huang E, Chen X. PMID: 31332290.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Cancer the'RBP'eutics-RNA-binding proteins as therapeutic targets for cancer. Pharmacol Ther. 2019 11; 203:107390. Mohibi S, Chen X, Zhang J. PMID: 31302171.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. A PolH Transcript with a Short 3'UTR Enhances PolH Expression and Mediates Cisplatin Resistance. Cancer Res. 2019 07 15; 79(14):3714-3724. Zhang J, Sun W, Ren C, Kong X, Yan W, Chen X. PMID: 31064846.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. Disruption of the Rbm38-eIF4E Complex with a Synthetic Peptide Pep8 Increases p53 Expression. Cancer Res. 2019 02 15; 79(4):807-818. Lucchesi CA, Zhang J, Ma B, Chen M, Chen X. PMID: 30591552.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Serine 195 phosphorylation in the RNA-binding protein Rbm38 increases p63 expression by modulating Rbm38's interaction with the Ago2-miR203 complex. J Biol Chem. 2019 02 15; 294(7):2449-2459. Zhang Y, Feng X, Sun W, Zhang J, Chen X. PMID: 30567739.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. p53 tumor suppressor and iron homeostasis. FEBS J. 2019 02; 286(4):620-629. Zhang J, Chen X. PMID: 30133149.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Clusterin, a Novel DEC1 Target, Modulates DNA Damage-Mediated Cell Death. Mol Cancer Res. 2018 11; 16(11):1641-1651. Ming X, Bao C, Hong T, Yang Y, Chen X, Jung YS, Qian Y. PMID: 30002194.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. The Rbm38-p63 feedback loop is critical for tumor suppression and longevity. Oncogene. 2018 05; 37(21):2863-2872. Jiang Y, Xu E, Zhang J, Chen M, Flores E, Chen X. PMID: 29520104.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Rbm24, a target of p53, is necessary for proper expression of p53 and heart development. Cell Death Differ. 2018 06; 25(6):1118-1130. Zhang M, Zhang Y, Xu E, Mohibi S, de Anda DM, Jiang Y, Zhang J, Chen X. PMID: 29358667.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. Genetic Ablation of Rbm38 Promotes Lymphomagenesis in the Context of Mutant p53 by Downregulating PTEN. Cancer Res. 2018 03 15; 78(6):1511-1521. Zhang J, Xu E, Ren C, Yang HJ, Zhang Y, Sun W, Kong X, Zhang W, Chen M, Huang E, Chen X. PMID: 29330147.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. Ninjurin 1 has two opposing functions in tumorigenesis in a p53-dependent manner. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):11500-11505. Yang HJ, Zhang J, Yan W, Cho SJ, Lucchesi C, Chen M, Huang EC, Scoumanne A, Zhang W, Chen X. PMID: 29073078.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. TAp63? and ?Np63? are regulated by RBM38 via mRNA stability and have an opposing function in growth suppression. Oncotarget. 2017 Oct 3; 5(0). Wensheng Yan, Yanhong Zhang, Xinbin Chen. .
      View in: Publisher Site   Mentions:
    15. Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2. Genes Dev. 2017 06 15; 31(12):1243-1256. Zhang Y, Qian Y, Zhang J, Yan W, Jung YS, Chen M, Huang E, Lloyd K, Duan Y, Wang J, Liu G, Chen X. PMID: 28747430.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. TAp63? and ?Np63? are regulated by RBM38 via mRNA stability and have an opposing function in growth suppression. Oncotarget. 2017 Oct 03; 8(45):78327-78339. Yan W, Zhang Y, Chen X. PMID: 29108232.
      View in: PubMed   Mentions:    Fields:    
    17. Modulation of the p53 family network by RNA-binding proteins. Transl Cancer Res. 2016 Dec; 5(6):676-684. Lucchesi C, Zhang J, Chen X. PMID: 28794999.
      View in: PubMed   Mentions:
    18. p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability. Oncotarget. 2016 Nov 29; 7(48):78255-78268. Zhang M, Zhang J, Yan W, Chen X. PMID: 27825141.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy. Cell Death Differ. 2016 11 01; 23(11):1886-1896. Wang J, Wang H, Wang LY, Cai D, Duan Z, Zhang Y, Chen P, Zou JX, Xu J, Chen X, Kung HJ, Chen HW. PMID: 27612013.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    20. A new function for p53 tetramerization domain in cell fate control. Cell Cycle. 2016 11; 15(21):2854-2855. Zhang J, Lucchesi C, Chen X. PMID: 27355441.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    21. Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation. Genes Dev. 2016 Mar 01; 30(5):522-34. Yan W, Scoumanne A, Jung YS, Xu E, Zhang J, Zhang Y, Ren C, Sun P, Chen X. PMID: 26915821.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    22. RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant Defense. J Biol Chem. 2016 Apr 29; 291(18):9629-37. Ren C, Zhang J, Yan W, Zhang Y, Chen X. PMID: 26907686.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. Companion animals: Translational scientist's new best friends. Sci Transl Med. 2015 Oct 07; 7(308):308ps21. Kol A, Arzi B, Athanasiou KA, Farmer DL, Nolta JA, Rebhun RB, Chen X, Griffiths LG, Verstraete FJ, Murphy CJ, Borjesson DL. PMID: 26446953.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    24. P73 tumor suppressor and its targets, p21 and PUMA, are required for madin-darby canine kidney cell morphogenesis by maintaining an appropriate level of epithelial to mesenchymal transition. Oncotarget. 2015 Jun 10; 6(16):13994-4004. Zhang Y, Young A, Zhang J, Chen X. PMID: 26101856.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    25. PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38. Oncogene. 2015 Nov 26; 34(48):5900-11. Zhang M, Xu E, Zhang J, Chen X. PMID: 25823026.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    26. PPM1D regulates p21 expression via dephoshporylation at serine 123. Cell Cycle. 2015; 14(4):641-7. Cao R, Zhang J, Zhang M, Chen X. PMID: 25590690.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    27. Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNA-binding protein and a p53 family target, via mRNA translation. Oncotarget. 2015 Jan 01; 6(1):305-16. Cho SJ, Teng IF, Zhang M, Yin T, Jung YS, Zhang J, Chen X. PMID: 25622105.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    28. Attenuated NER expressions of XPF and XPC associated with smoking are involved in the recurrence of bladder cancer. PLoS One. 2014; 9(12):e115224. Qiu J, Wang X, Meng X, Zheng Y, Li G, Ma J, Ye G, Li Y, Li J. PMID: 25535740.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    29. Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18637-42. Zhang J, Xu E, Ren C, Yan W, Zhang M, Chen M, Cardiff RD, Imai DM, Wisner E, Chen X. PMID: 25512531.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    30. DNA polymerase ? is regulated by poly(rC)-binding protein 1 via mRNA stability. Biochem J. 2014 Dec 15; 464(3):377-86. Ren C, Cho SJ, Jung YS, Chen X. PMID: 25268038.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    31. Arsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligase. PLoS One. 2014; 9(8):e103497. Yan W, Jung YS, Zhang Y, Chen X. PMID: 25116336.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    32. DEC1 coordinates with HDAC8 to differentially regulate TAp73 and ?Np73 expression. PLoS One. 2014; 9(1):e84015. Qian Y, Zhang J, Jung YS, Chen X. PMID: 24404147.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    33. Mutant p53 cooperates with knockdown of endogenous wild-type p53 to disrupt tubulogenesis in Madin-Darby canine kidney cells. PLoS One. 2013; 8(12):e85624. Zhang Y, Yan W, Chen X. PMID: 24386484.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    34. RNA-binding protein RBM24 regulates p63 expression via mRNA stability. Mol Cancer Res. 2014 Mar; 12(3):359-69. Xu E, Zhang J, Zhang M, Jiang Y, Cho SJ, Chen X. PMID: 24375645.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    35. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. J Biol Chem. 2014 Feb 07; 289(6):3164-75. Jiang Y, Zhang M, Qian Y, Xu E, Zhang J, Chen X. PMID: 24356969.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    36. Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1. Genes Dev. 2013 Oct 15; 27(20):2246-58. Zhang M, Zhang J, Chen X, Cho SJ, Chen X. PMID: 24142875.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    37. The p53-estrogen receptor loop in cancer. Curr Mol Med. 2013 Sep; 13(8):1229-40. Berger C, Qian Y, Chen X. PMID: 23865427.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    38. Poly (C)-binding protein 1 regulates p63 expression through mRNA stability. PLoS One. 2013; 8(8):e71724. Cho SJ, Jung YS, Chen X. PMID: 23940783.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    39. Regulation of Mdm2 mRNA stability by RNA-binding protein RNPC1. Oncotarget. 2013 Aug; 4(8):1121-2. Zhang J, Xu E, Chen X. PMID: 23912475.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    40. RNPC1, an RNA-binding protein and a p53 target, regulates macrophage inhibitory cytokine-1 (MIC-1) expression through mRNA stability. J Biol Chem. 2013 Aug 16; 288(33):23680-6. Yin T, Cho SJ, Chen X. PMID: 23836903.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    41. PUMA Cooperates with p21 to Regulate Mammary Epithelial Morphogenesis and Epithelial-To-Mesenchymal Transition. PLoS One. 2013; 8(6):e66464. Zhang Y, Yan W, Jung YS, Chen X. PMID: 23805223.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    42. Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality. Proc Natl Acad Sci U S A. 2013 Jun 04; 110(23):9362-7. Cho SJ, Rossi A, Jung YS, Yan W, Liu G, Zhang J, Zhang M, Chen X. PMID: 23690620.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    43. P63 regulates tubular formation via epithelial-to-mesenchymal transition. Oncogene. 2014 Mar 20; 33(12):1548-57. Zhang Y, Yan W, Chen X. PMID: 23542170.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    44. TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function. J Biol Chem. 2013 Mar 15; 288(11):7727-37. Zhang J, Xu E, Chen X. PMID: 23362263.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    45. Senescence regulation by the p53 protein family. Methods Mol Biol. 2013; 965:37-61. Qian Y, Chen X. PMID: 23296650.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    46. Corrigendum to “Development and characterization of 5 canine B-cell lymphoma cell lines” [Leuk. Res. 36(5) (2011) 601–606]. Leukemia Research. 2013 Jan 1; 37(1):120. Allison L. Zwingenberger, William Vernau, Changying Sh, Wensheng Yan, Xinbin Chen, Ira K. Gordon, Michael S. Kent. .
      View in: Publisher Site   Mentions:
    47. Arsenic suppresses cell survival via Pirh2-mediated proteasomal degradation of ?Np63 protein. J Biol Chem. 2013 Feb 01; 288(5):2907-13. Yan W, Chen X, Zhang Y, Zhang J, Jung YS, Chen X. PMID: 23271742.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    48. Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63. J Invest Dermatol. 2013 May; 133(5):1178-87. Jung YS, Qian Y, Yan W, Chen X. PMID: 23235527.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    49. Functional p53 determines docetaxel sensitivity in prostate cancer cells. Prostate. 2013 Mar; 73(4):418-27. Liu C, Zhu Y, Lou W, Nadiminty N, Chen X, Zhou Q, Shi XB, deVere White RW, Gao AC. PMID: 22996738.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    50. HuR is necessary for mammary epithelial cell proliferation and polarity at least in part via ?Np63. PLoS One. 2012; 7(9):e45336. Yan W, Zhang Y, Zhang J, Cho SJ, Chen X. PMID: 23028944.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    51. DEC1 and MIC-1: new players of p53-dependent cell fate decision. Cell Cycle. 2012 Oct 01; 11(19):3525-6. Qian Y, Jung YS, Chen X. PMID: 22935706.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    52. Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines. PLoS One. 2012; 7(8):e42960. Seo Kw, Holt R, Jung YS, Rodriguez CO, Chen X, Rebhun RB. PMID: 22927942.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    53. Serine 123 phosphorylation modulates p21 protein stability and activity by suppressing ubiquitin-independent proteasomal degradation. J Biol Chem. 2012 Oct 05; 287(41):34410-8. Chen X, Zhang J, Zhang M, Liu S, Yan W, Jung J, Chen X. PMID: 22908227.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    54. p53, a target of estrogen receptor (ER) a, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells. J Biol Chem. 2012 Aug 31; 287(36):30117-27. Berger CE, Qian Y, Liu G, Chen H, Chen X. PMID: 22787161.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    55. Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11300-5. Qian Y, Jung YS, Chen X. PMID: 22723347.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    56. Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cells. Cancer Res. 2012 Jul 01; 72(13):3381-92. Hertwig F, Meyer K, Braun S, Ek S, Spang R, Pfenninger CV, Artner I, Prost G, Chen X, Biegel JA, Judkins AR, Englund E, Nuber UA. PMID: 22719073.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    57. MDM2 expression is repressed by the RNA-binding protein RNPC1 via mRNA stability. Oncogene. 2013 Apr 25; 32(17):2169-78. Xu E, Zhang J, Chen X. PMID: 22710720.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    58. Histone methyltransferase NSD2/MMSET mediates constitutive NF-?B signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop. Mol Cell Biol. 2012 Aug; 32(15):3121-31. Yang P, Guo L, Duan ZJ, Tepper CG, Xue L, Chen X, Kung HJ, Gao AC, Zou JX, Chen HW. PMID: 22645312.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    59. p73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stability. Mol Cell Biol. 2012 Jul; 32(13):2336-48. Yan W, Zhang J, Zhang Y, Jung YS, Chen X. PMID: 22508983.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    60. Pirh2 RING-finger E3 ubiquitin ligase: its role in tumorigenesis and cancer therapy. FEBS Lett. 2012 May 21; 586(10):1397-402. Jung YS, Qian Y, Chen X. PMID: 22673504.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    61. MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth. PLoS One. 2012; 7(3):e32832. Nadiminty N, Tummala R, Lou W, Zhu Y, Shi XB, Zou JX, Chen H, Zhang J, Chen X, Luo J, deVere White RW, Kung HJ, Evans CP, Gao AC. PMID: 22479342.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    62. Mammary epithelial cell polarity is regulated differentially by p73 isoforms via epithelial-to-mesenchymal transition. J Biol Chem. 2012 May 18; 287(21):17746-53. Zhang Y, Yan W, Jung YS, Chen X. PMID: 22457351.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    63. Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8. Oncogene. 2013 Jan 31; 32(5):599-609. Yan W, Liu S, Xu E, Zhang J, Zhang Y, Chen X, Chen X. PMID: 22391568.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    64. The RNA-binding protein RNPC1 stabilizes the mRNA encoding the RNA-binding protein HuR and cooperates with HuR to suppress cell proliferation. J Biol Chem. 2012 Apr 27; 287(18):14535-44. Cho SJ, Jung YS, Zhang J, Chen X. PMID: 22371495.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    65. Development and characterization of 5 canine B-cell lymphoma cell lines. Leuk Res. 2012 May; 36(5):601-6. Zwingenberger AL, Vernau W, Shi C, Yan W, Chen X, Gordon IK, Kent MS. PMID: 22136758.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    66. MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells. J Biol Chem. 2012 Jan 06; 287(2):1527-37. Nadiminty N, Tummala R, Lou W, Zhu Y, Zhang J, Chen X, eVere White RW, Kung HJ, Evans CP, Gao AC. PMID: 22128178.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    67. Role of Pirh2 in mediating the regulation of p53 and c-Myc. PLoS Genet. 2011 Nov; 7(11):e1002360. Hakem A, Bohgaki M, Lemmers B, Tai E, Salmena L, Matysiak-Zablocki E, Jung YS, Karaskova J, Kaustov L, Duan S, Madore J, Boutros P, Sheng Y, Chesi M, Bergsagel PL, Perez-Ordonez B, Mes-Masson AM, Penn L, Squire J, Chen X, Jurisica I, Arrowsmith C, Sanchez O, Benchimol S, Hakem R. PMID: 22125490.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    68. DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation. DNA Repair (Amst). 2012 Feb 01; 11(2):177-84. Jung YS, Qian Y, Chen X. PMID: 22056306.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    69. Novel role of Wip1 in p53-mediated cell homeostasis under non-stress conditions. Cell Cycle. 2011 Oct 01; 10(19):3235. Zhang J, Chen X. PMID: 21946519.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    70. The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation. J Biol Chem. 2011 Oct 14; 286(41):35388-95. Jung YS, Qian Y, Chen X. PMID: 21852228.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    71. Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. Mol Cell Biol. 2011 Oct; 31(19):3997-4006. Jung YS, Hakem A, Hakem R, Chen X. PMID: 21791603.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    72. Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas. Genes Dev. 2011 Jul 15; 25(14):1528-43. Zhang J, Cho SJ, Shu L, Yan W, Guerrero T, Kent M, Skorupski K, Chen H, Chen X. PMID: 21764855.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    73. Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression. J Biol Chem. 2011 May 20; 286(20):17478-86. Yan W, Zhang Y, Zhang J, Liu S, Cho SJ, Chen X. PMID: 21454520.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    74. Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions. J Biol Chem. 2011 May 06; 286(18):16218-28. Zhang Y, Yan W, Chen X. PMID: 21454711.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    75. DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. J Biol Chem. 2011 Apr 08; 286(14):12033-41. Qian Y, Jung YS, Chen X. PMID: 21317427.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    76. Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells. PLoS One. 2010 Oct 18; 5(10):e13459. Wang F, Fu X, Chen X, Chen X, Zhao Y. PMID: 20976134.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    77. The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability. Nucleic Acids Res. 2011 Jan; 39(1):213-24. Scoumanne A, Cho SJ, Zhang J, Chen X. PMID: 20817677.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    78. Myosin VI is differentially regulated by DNA damage in p53- and cell type-dependent manners. J Biol Chem. 2010 Aug 27; 285(35):27159-66. Cho SJ, Chen X. PMID: 20576604.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    79. SNF5, a core component of the SWI/SNF complex, is necessary for p53 expression and cell survival, in part through eIF4E. Oncogene. 2010 Jul 15; 29(28):4090-100. Xu Y, Yan W, Chen X. PMID: 20473326.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    80. RNPC1, an RNA-binding protein and a target of the p53 family, regulates p63 expression through mRNA stability. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9614-9. Zhang J, Jun Cho S, Chen X. PMID: 20457941.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    81. Tumor suppression by p53: making cells senescent. Histol Histopathol. 2010 04; 25(4):515-26. Qian Y, Chen X. PMID: 20183804.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    82. Characterization of functional domains necessary for mutant p53 gain of function. J Biol Chem. 2010 May 07; 285(19):14229-38. Yan W, Chen X. PMID: 20212049.
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    83. Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal. 2010 Jul; 22(7):1003-12. Jung YS, Qian Y, Chen X. PMID: 20100570.
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    84. RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability. Nucleic Acids Res. 2010 Apr; 38(7):2256-67. Cho SJ, Zhang J, Chen X. PMID: 20064878.
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    85. Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation. Mol Cell Biol. 2010 Feb; 30(4):1041-8. Jung YS, Liu G, Chen X. PMID: 20008555.
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    86. The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress. Cancer Res. 2009 Aug 01; 69(15):6049-56. Zhang Y, Qian Y, Lu W, Chen X. PMID: 19602589.
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    87. PRMT5 is required for cell-cycle progression and p53 tumor suppressor function. Nucleic Acids Res. 2009 Aug; 37(15):4965-76. Scoumanne A, Zhang J, Chen X. PMID: 19528079.
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    88. Identification of GRO1 as a critical determinant for mutant p53 gain of function. J Biol Chem. 2009 May 01; 284(18):12178-87. Yan W, Chen X. PMID: 19258312.
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    89. Establishment of a dog model for the p53 family pathway and identification of a novel isoform of p21 cyclin-dependent kinase inhibitor. Mol Cancer Res. 2009 Jan; 7(1):67-78. Zhang J, Chen X, Kent MS, Rodriguez CO, Chen X. PMID: 19147538.
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    90. Posttranscriptional regulation of p53 and its targets by RNA-binding proteins. Curr Mol Med. 2008 Dec; 8(8):845-9. Zhang J, Chen X. PMID: 19075680.
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    91. Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survival. J Biol Chem. 2008 Nov 07; 283(45):30689-98. Zhang Y, Shu L, Chen X. PMID: 18779328.
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    92. Protein methylation: a new mechanism of p53 tumor suppressor regulation. Histol Histopathol. 2008 09; 23(9):1143-9. Scoumanne A, Chen X. PMID: 18581285.
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    93. Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations. Cancer Res. 2008 Aug 15; 68(16):6789-96. Yan W, Liu G, Scoumanne A, Chen X. PMID: 18701504.
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    94. ID1, inhibitor of differentiation/DNA binding, is an effector of the p53-dependent DNA damage response pathway. J Biol Chem. 2008 Aug 15; 283(33):22410-6. Qian Y, Chen X. PMID: 18556654.
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    95. The proline-rich domain in p63 is necessary for the transcriptional and apoptosis-inducing activities of TAp63. Oncogene. 2008 May 01; 27(20):2843-50. Helton ES, Zhang J, Chen X. PMID: 18037962.
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    96. DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem. 2008 Feb 01; 283(5):2896-905. Qian Y, Zhang J, Yan B, Chen X. PMID: 18025081.
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    97. The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes. J Biol Chem. 2007 Dec 28; 282(52):37429-35. Xu Y, Zhang J, Chen X. PMID: 17938176.
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    98. Targeted repression of bone morphogenetic protein 7, a novel target of the p53 family, triggers proliferative defect in p53-deficient breast cancer cells. Cancer Res. 2007 Oct 01; 67(19):9117-24. Yan W, Chen X. PMID: 17909016.
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    99. Myocardial smad4 is essential for cardiogenesis in mouse embryos. Circ Res. 2007 Aug 03; 101(3):277-85. Song L, Yan W, Chen X, Deng CX, Wang Q, Jiao K. PMID: 17585069.
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    100. The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners. J Biol Chem. 2007 May 25; 282(21):15471-5. Scoumanne A, Chen X. PMID: 17409384.
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    101. Histone deacetylase 2 modulates p53 transcriptional activities through regulation of p53-DNA binding activity. Cancer Res. 2007 Apr 01; 67(7):3145-52. Harms KL, Chen X. PMID: 17409421.
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    102. DeltaNp73 modulates nerve growth factor-mediated neuronal differentiation through repression of TrkA. Mol Cell Biol. 2007 May; 27(10):3868-80. Zhang J, Chen X. PMID: 17353261.
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    103. p53 modulation of the DNA damage response. J Cell Biochem. 2007 Mar 01; 100(4):883-96. Helton ES, Chen X. PMID: 17031865.
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    104. The p53 family: prospect for cancer gene therapy. Cancer Biol Ther. 2007 Jan; 6(1):116-8. Zhang J, Chen X. PMID: 17612008.
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    105. p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosis. J Neuropathol Exp Neurol. 2007 Jan; 66(1):66-74. Geng Y, Akhtar RS, Shacka JJ, Klocke BJ, Zhang J, Chen X, Roth KA. PMID: 17204938.
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    106. RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript. Genes Dev. 2006 Nov 01; 20(21):2961-72. Shu L, Yan W, Chen X. PMID: 17050675.
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    107. Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family. J Biol Chem. 2006 Sep 08; 281(36):26702-13. Xu Y, Chen X. PMID: 16831876.
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    108. The epithelial cell transforming sequence 2, a guanine nucleotide exchange factor for Rho GTPases, is repressed by p53 via protein methyltransferases and is required for G1-S transition. Cancer Res. 2006 Jun 15; 66(12):6271-9. Scoumanne A, Chen X. PMID: 16778203.
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    109. The functional domains in p53 family proteins exhibit both common and distinct properties. Cell Death Differ. 2006 Jun; 13(6):890-7. Harms KL, Chen X. PMID: 16543939.
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    110. p19ras brings a new twist to the regulation of p73 by Mdm2. Sci STKE. 2006 May 30; 2006(337):pe24. Harms KL, Chen X. PMID: 16738062.
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    111. p53 is required for nerve growth factor-mediated differentiation of PC12 cells via regulation of TrkA levels. Cell Death Differ. 2006 Dec; 13(12):2118-28. Zhang J, Yan W, Chen X. PMID: 16729028.
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    112. DNA Polymerase ?, the Product of the Xeroderma Pigmentosum Variant Gene and a Target of p53, Modulates the DNA Damage Checkpoint and p53 Activation. Molecular and Cellular Biology. 2006 May 1; 26(9):3680-3680. Gang Liu, Xinbin Chen. .
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    114. Regulation of the p53 transcriptional activity. J Cell Biochem. 2006 Feb 15; 97(3):448-58. Liu G, Chen X. PMID: 16288459.
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    115. DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation. Mol Cell Biol. 2006 Feb; 26(4):1398-413. Liu G, Chen X. PMID: 16449651.
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    116. GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner. J Biol Chem. 2006 Mar 24; 281(12):7856-62. Yan W, Chen X. PMID: 16446369.
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    117. Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells. Oncogene. 2006 Jan 26; 25(4):622-32. Tsai MH, Chen X, Chandramouli GV, Chen Y, Yan H, Zhao S, Keng P, Liber HL, Coleman CN, Mitchell JB, Chuang EY. PMID: 16247478.
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    118. The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63. J Biol Chem. 2006 Feb 03; 281(5):2533-42. Helton ES, Zhu J, Chen X. PMID: 16319057.
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    119. Structural basis for gene activation by p53 family members. Cancer Biol Ther. 2005 Nov; 4(11):1178-85. Scoumanne A, Harms KL, Chen X. PMID: 16294021.
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    120. Genistein, a dietary isoflavone, down-regulates the MDM2 oncogene at both transcriptional and posttranslational levels. Cancer Res. 2005 Sep 15; 65(18):8200-8. Li M, Zhang Z, Hill DL, Chen X, Wang H, Zhang R. PMID: 16166295.
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    121. The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73. J Biol Chem. 2005 May 20; 280(20):20111-9. Liu G, Chen X. PMID: 15769743.
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    122. The C terminus of p53 family proteins is a cell fate determinant. Mol Cell Biol. 2005 Mar; 25(5):2014-30. Harms KL, Chen X. PMID: 15713654.
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    123. The common and distinct target genes of the p53 family transcription factors. Cell Mol Life Sci. 2004 Apr; 61(7-8):822-42. Harms K, Nozell S, Chen X. PMID: 15095006.
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    124. Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes. Oncogene. 2004 Mar 25; 23(13):2330-8. Willis A, Jung EJ, Wakefield T, Chen X. PMID: 14743206.
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    125. MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. J Biol Chem. 2004 Apr 16; 279(16):16000-6. Zhang Z, Wang H, Li M, Agrawal S, Chen X, Zhang R. PMID: 14761977.
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    126. DeltaNp73beta is active in transactivation and growth suppression. Mol Cell Biol. 2004 Jan; 24(2):487-501. Liu G, Nozell S, Xiao H, Chen X. PMID: 14701724.
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    127. Glycogen synthase kinase-3beta (GSK3beta) binds to and promotes the actions of p53. J Biol Chem. 2003 Dec 05; 278(49):48872-9. Watcharasit P, Bijur GN, Song L, Zhu J, Chen X, Jope RS. PMID: 14523002.
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    128. p73 can suppress the proliferation of cells that express mutant p53. Oncogene. 2003 Aug 21; 22(35):5481-95. Willis AC, Pipes T, Zhu J, Chen X. PMID: 12934108.
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    129. Characterization of p73 functional domains necessary for transactivation and growth suppression. Oncogene. 2003 Jul 10; 22(28):4333-47. Nozell S, Wu Y, McNaughton K, Liu G, Willis A, Paik JC, Chen X. PMID: 12853970.
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    130. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein. J Biol Chem. 2003 May 09; 278(19):17557-65. Liu G, Xia T, Chen X. PMID: 12609999.
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    131. Isolation and characterization of fourteen novel putative and nine known target genes of the p53 family. Cancer Biol Ther. 2003 Jan-Feb; 2(1):55-62. Chen X, Liu G, Zhu J, Jiang J, Nozell S, Willis A. PMID: 12673118.
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    132. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis. Oncogene. 2002 Oct 17; 21(47):7195-204. Liu G, Chen X. PMID: 12370809.
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    133. Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines. Cancer Chemother Pharmacol. 2002 Nov; 50(5):397-404. Woessmann W, Chen X, Borkhardt A. PMID: 12439598.
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    134. Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):7951-5. Watcharasit P, Bijur GN, Zmijewski JW, Song L, Zmijewska A, Chen X, Johnson GV, Jope RS. PMID: 12048243.
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    135. The promise and obstacle of p53 as a cancer therapeutic agent. Curr Mol Med. 2002 Jun; 2(4):329-45. Willis AC, Chen X. PMID: 12108946.
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    136. P53 is necessary for the apoptotic response mediated by a transient increase of Ras activity. Mol Cell Biol. 2002 May; 22(9):2928-38. Ma P, Magut M, Chen X, Chen CY. PMID: 11940651.
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    137. Cyclin G: a regulator of the p53-Mdm2 network. Dev Cell. 2002 May; 2(5):518-9. Chen X. PMID: 12015958.
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    138. p21B, a variant of p21(Waf1/Cip1), is induced by the p53 family. Oncogene. 2002 Feb 14; 21(8):1285-94. Nozell S, Chen X. PMID: 11850848.
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    139. The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells. Oncogene. 2002 Jan 03; 21(1):9-21. Baptiste N, Friedlander P, Chen X, Prives C. PMID: 11791172.
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    140. Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis. Oncogene. 2001 Oct 04; 20(45):6503-15. Dohn M, Jiang J, Chen X. PMID: 11641774.
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    141. p73 cooperates with DNA damage agents to induce apoptosis in MCF7 cells in a p53-dependent manner. Oncogene. 2001 Jul 05; 20(30):4050-7. Zhu J, Nozell S, Wang J, Jiang J, Zhou W, Chen X. PMID: 11494133.
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    142. p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes. Oncogene. 2001 May 31; 20(25):3193-205. Dohn M, Zhang S, Chen X. PMID: 11423969.
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    143. p73 is transcriptionally regulated by DNA damage, p53, and p73. Oncogene. 2001 Feb 08; 20(6):769-74. Chen X, Zheng Y, Zhu J, Jiang J, Wang J. PMID: 11314010.
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    144. Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family. FEBS Lett. 2001 Jan 26; 489(1):4-7. Zheng X, Chen X. PMID: 11231003.
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    145. Definition of the p53 functional domains necessary for inducing apoptosis. J Biol Chem. 2000 Dec 22; 275(51):39927-34. Zhu J, Zhang S, Jiang J, Chen X. PMID: 10982799.
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    146. MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M. Mol Cell Biol. 2000 Aug; 20(15):5602-18. Zhu J, Chen X. PMID: 10891498.
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    147. Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53. Oncogene. 2000 Mar 30; 19(14):1843-8. Wang J, Shou J, Chen X. PMID: 10777218.
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    148. p53 induces TAP1 and enhances the transport of MHC class I peptides. Oncogene. 1999 Dec 16; 18(54):7740-7. Zhu K, Wang J, Zhu J, Jiang J, Shou J, Chen X. PMID: 10618714.
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    149. The p53 family: same response, different signals? Mol Med Today. 1999 Sep; 5(9):387-92. Chen X. PMID: 10462750.
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    151. The potential tumor suppressor p73 differentially regulates cellular p53 target genes. Cancer Res. 1998 Nov 15; 58(22):5061-5. Zhu J, Jiang J, Zhou W, Chen X. PMID: 9823311.
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    153. Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol. 1998 Jan; 18(1):629-43. Niculescu AB, Chen X, Smeets M, Hengst L, Prives C, Reed SI. PMID: 9418909.
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    154. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Mol Cell Biol. 1997 Dec; 17(12):7220-9. Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ. PMID: 9372954.
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    156. p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis. Cancer Res. 1995 Oct 01; 55(19):4257-63. Chen X, Bargonetti J, Prives C. PMID: 7671232.
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    157. A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein. Genes Dev. 1993 Dec; 7(12B):2565-74. Bargonetti J, Manfredi JJ, Chen X, Marshak DR, Prives C. PMID: 8276239.
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    159. The p53 protein is an unusually shaped tetramer that binds directly to DNA. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3319-23. Friedman PN, Chen X, Bargonetti J, Prives C. PMID: 8475074.
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    160. Expression of the Marek's disease virus homolog of herpes simplex virus glycoprotein B in Escherichia coli and its identification as B antigen. J Virol. 1992 Jul; 66(7):4390-8. Chen X, Velicer LF. PMID: 1318409.
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    161. Identification of a unique Marek's disease virus gene which encodes a 38-kilodalton phosphoprotein and is expressed in both lytically infected cells and latently infected lymphoblastoid tumor cells. J Virol. 1992 Jan; 66(1):85-94. Chen XB, Sondermeijer PJ, Velicer LF. PMID: 1309266.
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