Allen C Gao

Title(s)Professor, MED: Urologic Surgery
SchoolSchool of Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Targeting AR variants in advanced prostate cancer
    NIH/NCI R01CA225836Jan 1, 2019 - Dec 31, 2023
    Role: Principal Investigator
    Novel mechanisms of resistance to antiandrogen therapies
    VA I01BX004036Jul 1, 2018 - Jun 30, 2022
    Role: Principal Investigator
    Omics in Urologic Research-New Frontiers Driving Precision Medicine
    NIH/NIDDK R13DK104455Sep 8, 2014 - Aug 31, 2015
    Role: Principal Investigator
    The role of p52 in prostate cancer
    VA I01BX002653Jul 1, 2014 - Jun 30, 2018
    Role: Principal Investigator
    (PQD-1) NF-kB activation and enzalutamide therapy in metastatic castration resist
    NIH/NCI R21CA179970Sep 12, 2013 - Aug 31, 2015
    Role: Principal Investigator
    Novel roles of microRNA in androgen receptor signaling
    NIH/NCI R01CA168601Apr 1, 2013 - Mar 31, 2018
    Role: Principal Investigator
    Role of Rho GDP dissociation inhibitors in androgen signaling in prostate cancer
    VA I01BX000526Apr 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    Interleukin-6 and castration-resistant prostate cancer
    NIH/NCI R01CA140468Apr 1, 2010 - Feb 28, 2015
    Role: Principal Investigator
    Selenium regulates androgen receptor signaling in prostate cancer
    NIH/NCI R01CA118887Mar 6, 2006 - Jul 31, 2012
    Role: Principal Investigator
    IL-4 and androgen receptor signaling in prostate cancer
    NIH/NCI R01CA109441Apr 1, 2005 - Feb 29, 2012
    Role: Principal Investigator
    Stat3 in Androgen Receptor Signaling in Prostate Cancer
    NIH/NCI R01CA090271Jul 20, 2001 - May 31, 2007
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer. Nat Commun. 2024 Aug 05; 15(1):6626. Xu P, Yang JC, Chen B, Ning S, Zhang X, Wang L, Nip C, Shen Y, Johnson OT, Grigorean G, Phinney B, Liu L, Wei Q, Corey E, Tepper CG, Chen HW, Evans CP, Dall'Era MA, Gao AC, Gestwicki JE, Liu C. PMID: 39103353; PMCID: PMC11300456.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. LX1 Targets Androgen Receptor Variants and AKR1C3 to overcome Therapy Resistance in Advanced Prostate Cancer. Cancer Res. 2024 Aug 01. Ning S, Armstrong CM, Xing E, Leslie AR, Gao RY, Sharifi M, Schaaf ZA, Lou W, Han X, Xu DH, Yang R, Cheng J, Mohammed S, Mitsiades N, Liu C, Lombard AP, Wu CY, Cheng X, Li PK, Gao AC. PMID: 39088701.
      View in: PubMed   Mentions:    Fields:    
    3. Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Oncogene. 2024 Jul; 43(30):2325-2337. Chen B, Xu P, Yang JC, Nip C, Wang L, Shen Y, Ning S, Shang Y, Corey E, Gao AC, Gestwicki JE, Wei Q, Liu L, Liu C. PMID: 38877132; PMCID: PMC11286220.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Res Sq. 2024 Mar 27. Liu C, Chen B, Xu P, Yang J, Nip C, Wang L, Shen Y, Ning S, Shang Y, Corey E, Gao AC, Gestwicki J, Wei Q, Liu L. PMID: 38585965; PMCID: PMC10996809.
      View in: PubMed   Mentions:
    5. Stromal-derived MAOB promotes prostate cancer growth and progression. Sci Adv. 2024 Feb 09; 10(6):eadi4935. Pu T, Wang J, Wei J, Zeng A, Zhang J, Chen J, Yin L, Li J, Lin TP, Melamed J, Corey E, Gao AC, Wu BJ. PMID: 38335292; PMCID: PMC10857382.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. IGFBP3 promotes resistance to Olaparib via modulating EGFR signaling in advanced prostate cancer. iScience. 2024 Feb 16; 27(2):108984. Leslie AR, Ning S, Armstrong CM, D'Abronzo LS, Sharifi M, Schaaf ZA, Lou W, Liu C, Evans CP, Lombard AP, Gao AC. PMID: 38327800; PMCID: PMC10847745.
      View in: PubMed   Mentions:
    7. Genomic and Evolutionary Characterization of Concurrent Intraductal Carcinoma and Adenocarcinoma of the Prostate. Cancer Res. 2024 01 02; 84(1):154-167. Zhao J, Xu N, Zhu S, Nie L, Zhang M, Zheng L, Cai D, Sun X, Chen J, Dai J, Ni Y, Wang Z, Zhang X, Liang J, Chen Y, Hu X, Pan X, Yin X, Liu H, Zhao F, Zhang B, Chen H, Miao J, Qin C, Zhao X, Yao J, Liu Z, Liao B, Wei Q, Li X, Liu J, Gao AC, Huang H, Shen P, Chen N, Zeng H, Sun G. PMID: 37847513.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Therapeutic Resistance Models and Treatment Sequencing in Advanced Prostate Cancer. Cancers (Basel). 2023 Nov 03; 15(21). Schaaf ZA, Ning S, Leslie AR, Sharifi M, Han X, Armstrong C, Lou W, Lombard AP, Liu C, Gao AC. PMID: 37958444; PMCID: PMC10650051.
      View in: PubMed   Mentions: 1  
    9. Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models. Pharmacol Res. 2023 03; 189:106692. Xu P, Yang JC, Ning S, Chen B, Nip C, Wei Q, Liu L, Johnson OT, Gao AC, Gestwicki JE, Evans CP, Liu C. PMID: 36773708; PMCID: PMC10162009.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. Novel inhibition of AKR1C3 and androgen receptor axis by PTUPB synergizes enzalutamide treatment in advanced prostate cancer. Oncogene. 2023 02; 42(9):693-707. Yang JC, Xu P, Ning S, Wasielewski LJ, Adomat H, Hwang SH, Morisseau C, Gleave M, Corey E, Gao AC, Lara PN, Evans CP, Hammock BD, Liu C. PMID: 36596844; PMCID: PMC9975039.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    11. Wntless expression promotes lineage plasticity and is associated with neuroendocrine prostate cancer. Am J Clin Exp Urol. 2022; 10(5):299-310. D'Abronzo LS, Lombard AP, Ning S, Armstong CM, Leslie AR, Sharifi M, Schaaf ZA, Lou W, Gao AC. PMID: 36313205; PMCID: PMC9605943.
      View in: PubMed   Mentions: 1  
    12. Bioengineered BERA-Wnt5a siRNA Targeting Wnt5a/FZD2 Signaling Suppresses Advanced Prostate Cancer Tumor Growth and Enhances Enzalutamide Treatment. Mol Cancer Ther. 2022 10 07; 21(10):1594-1607. Ning S, Liu C, Lou W, Yang JC, Lombard AP, D'Abronzo LS, Batra N, Yu AM, Leslie AR, Sharifi M, Evans CP, Gao AC. PMID: 35930737; PMCID: PMC9547958.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    13. Activation of neural lineage networks and ARHGEF2 in enzalutamide-resistant and neuroendocrine prostate cancer and association with patient outcomes. Commun Med (Lond). 2022; 2:118. Ning S, Zhao J, Lombard AP, D'Abronzo LS, Leslie AR, Sharifi M, Lou W, Liu C, Yang JC, Evans CP, Corey E, Chen HW, Yu A, Ghosh PM, Gao AC. PMID: 36159187; PMCID: PMC9492734.
      View in: PubMed   Mentions: 4  
    14. Neuropilin-2 promotes lineage plasticity and progression to neuroendocrine prostate cancer. Oncogene. 2022 09; 41(37):4307-4317. Wang J, Li J, Yin L, Pu T, Wei J, Karthikeyan V, Lin TP, Gao AC, Wu BJ. PMID: 35986103; PMCID: PMC9464715.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    15. Olaparib-Induced Senescence Is Bypassed through G2-M Checkpoint Override in Olaparib-Resistant Prostate Cancer. Mol Cancer Ther. 2022 04 01; 21(4):677-685. Lombard AP, Armstrong CM, D'Abronzo LS, Ning S, Leslie AR, Sharifi M, Lou W, Evans CP, Dall'Era M, Chen HW, Chen X, Gao AC. PMID: 35086956; PMCID: PMC8983570.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. Editorial Expression of Concern: Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway. Oncogene. 2021 11; 40(47):6547. Lee SO, Lou W, Hou M, Onate SA, Gao AC. PMID: 34599276.
      View in: PubMed   Mentions:    Fields:    
    17. Dysregulated androgen synthesis and anti-androgen resistance in advanced prostate cancer. Am J Clin Exp Urol. 2021; 9(4):292-300. Armstrong CM, Gao AC. PMID: 34541028; PMCID: PMC8446765.
      View in: PubMed   Mentions: 6  
    18. Circulating tumour DNA reveals genetic traits of patients with intraductal carcinoma of the prostate. BJU Int. 2022 03; 129(3):345-355. Zhao J, Sun G, Zhu S, Dai J, Chen J, Zhang M, Ni Y, Zhang H, Shen P, Zhao X, Zhang B, Pan X, Nie L, Yin X, Liang J, Zhang X, Wang Z, Zhu X, Liao B, Liu Z, Armstrong CM, Gao AC, Huang H, Chen N, Zeng H. PMID: 34185954.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    19. Activation of the ABCB1 Amplicon in Docetaxel- and Cabazitaxel-Resistant Prostate Cancer Cells. Mol Cancer Ther. 2021 10; 20(10):2061-2070. Lombard AP, Lou W, Armstrong CM, D'Abronzo LS, Ning S, Evans CP, Gao AC. PMID: 34326198; PMCID: PMC8492550.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. ARVib suppresses growth of advanced prostate cancer via inhibition of androgen receptor signaling. Oncogene. 2021 Sep; 40(35):5379-5392. Liu C, Armstrong CM, Ning S, Yang JC, Lou W, Lombard AP, Zhao J, Wu CY, Yu A, Evans CP, Tepper CG, Li PK, Gao AC. PMID: 34272475; PMCID: PMC8413131.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    21. Bidirectional Cross-talk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer. Cancer Res. 2021 08 15; 81(16):4275-4289. Wei J, Yin L, Li J, Wang J, Pu T, Duan P, Lin TP, Gao AC, Wu BJ. PMID: 34167949; PMCID: PMC8373824.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    22. Phase Ib trial of reformulated niclosamide with abiraterone/prednisone in men with castration-resistant prostate cancer. Sci Rep. 2021 03 18; 11(1):6377. Parikh M, Liu C, Wu CY, Evans CP, Dall'Era M, Robles D, Lara PN, Agarwal N, Gao AC, Pan CX. PMID: 33737681; PMCID: PMC7973745.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCTClinical Trials
    23. WLS-Wnt signaling promotes neuroendocrine prostate cancer. iScience. 2021 Jan 22; 24(1):101970. Bland T, Wang J, Yin L, Pu T, Li J, Gao J, Lin TP, Gao AC, Wu BJ. PMID: 33437943; PMCID: PMC7788232.
      View in: PubMed   Mentions: 28  
    24. The Androgen Receptor in Prostate Cancer: Effect of Structure, Ligands and Spliced Variants on Therapy. Biomedicines. 2020 Oct 15; 8(10). Messner EA, Steele TM, Tsamouri MM, Hejazi N, Gao AC, Mudryj M, Ghosh PM. PMID: 33076388; PMCID: PMC7602609.
      View in: PubMed   Mentions: 32  
    25. Steroid Sulfatase Stimulates Intracrine Androgen Synthesis and is a Therapeutic Target for Advanced Prostate Cancer. Clin Cancer Res. 2020 11 15; 26(22):6064-6074. Armstrong CM, Liu C, Liu L, Yang JC, Lou W, Zhao R, Ning S, Lombard AP, Zhao J, D'Abronzo LS, Evans CP, Li PK, Gao AC. PMID: 32928794; PMCID: PMC7669645.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    26. Cross-Resistance Among Next-Generation Antiandrogen Drugs Through the AKR1C3/AR-V7 Axis in Advanced Prostate Cancer. Mol Cancer Ther. 2020 08; 19(8):1708-1718. Zhao J, Ning S, Lou W, Yang JC, Armstrong CM, Lombard AP, D'Abronzo LS, Evans CP, Gao AC, Liu C. PMID: 32430485; PMCID: PMC8855880.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    27. Germline and somatic DNA repair gene alterations in prostate cancer. Cancer. 2020 07 01; 126(13):2980-2985. Dall'Era MA, McPherson JD, Gao AC, DeVere White RW, Gregg JP, Lara PN. PMID: 32315455.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    28. Resistance Mechanisms to Taxanes and PARP Inhibitors in Advanced Prostate Cancer. Curr Opin Endocr Metab Res. 2020 Feb; 10:16-22. Lombard AP, Gao AC. PMID: 32258820; PMCID: PMC7111181.
      View in: PubMed   Mentions: 4  
    29. Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer. Sci Transl Med. 2019 12 04; 11(521). Li Y, He Y, Butler W, Xu L, Chang Y, Lei K, Zhang H, Zhou Y, Gao AC, Zhang Q, Taylor DG, Cheng D, Farber-Katz S, Karam R, Landrith T, Li B, Wu S, Hsuan V, Yang Q, Hu H, Chen X, Flowers M, McCall SJ, Lee JK, Smith BA, Park JW, Goldstein AS, Witte ON, Wang Q, Rettig MB, Armstrong AJ, Cheng Q, Huang J. PMID: 31801883; PMCID: PMC7238624.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    30. Therapeutic Targeting of MDR1 Expression by RORγ Antagonists Resensitizes Cross-Resistant CRPC to Taxane via Coordinated Induction of Cell Death Programs. Mol Cancer Ther. 2020 02; 19(2):364-374. Wang Y, Huang Z, Chen CZ, Liu C, Evans CP, Gao AC, Zhou F, Chen HW. PMID: 31712394.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    31. Wntless promotes cellular viability and resistance to enzalutamide in castration-resistant prostate cancer cells. Am J Clin Exp Urol. 2019; 7(4):203-214. Lombard AP, Liu C, Armstrong CM, D'Abronzo LS, Lou W, Evans CP, Gao AC. PMID: 31511827; PMCID: PMC6734040.
      View in: PubMed   Mentions: 9  
    32. GnRH Antagonists Have Direct Inhibitory Effects On Castration-Resistant Prostate Cancer Via Intracrine Androgen and AR-V7 Expression. Mol Cancer Ther. 2019 10; 18(10):1811-1821. Cucchiara V, Yang JC, Liu C, Adomat HH, Tomlinson Guns ES, Gleave ME, Gao AC, Evans CP. PMID: 31341032.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    33. AKR1C3 Promotes AR-V7 Protein Stabilization and Confers Resistance to AR-Targeted Therapies in Advanced Prostate Cancer. Mol Cancer Ther. 2019 10; 18(10):1875-1886. Liu C, Yang JC, Armstrong CM, Lou W, Liu L, Qiu X, Zou B, Lombard AP, D'Abronzo LS, Evans CP, Gao AC. PMID: 31308078; PMCID: PMC6995728.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    34. Overexpressed ABCB1 Induces Olaparib-Taxane Cross-Resistance in Advanced Prostate Cancer. Transl Oncol. 2019 Jul; 12(7):871-878. Lombard AP, Liu C, Armstrong CM, D'Abronzo LS, Lou W, Chen H, Dall'Era M, Ghosh PM, Evans CP, Gao AC. PMID: 31075528; PMCID: PMC6510951.
      View in: PubMed   Mentions: 14  
    35. A Circulating Tumor Cell-RNA Assay for Assessment of Androgen Receptor Signaling Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer. Theranostics. 2019; 9(10):2812-2826. Jan YJ, Yoon J, Chen JF, Teng PC, Yao N, Cheng S, Lozano A, Chu GCY, Chung H, Lu YT, Chen PJ, Wang JJ, Lee YT, Kim M, Zhu Y, Knudsen BS, Feng FY, Garraway IP, Gao AC, Chung LWK, Freeman MR, You S, Tseng HR, Posadas EM. PMID: 31244925; PMCID: PMC6568173.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    36. IFNγ, a Double-Edged Sword in Cancer Immunity and Metastasis. Cancer Res. 2019 03 15; 79(6):1032-1033. Liu C, Gao AC. PMID: 30877097.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    37. MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer. Prostate Cancer Prostatic Dis. 2019 12; 22(4):531-538. Nickols NG, Nazarian R, Zhao SG, Tan V, Uzunangelov V, Xia Z, Baertsch R, Neeman E, Gao AC, Thomas GV, Howard L, De Hoedt AM, Stuart J, Goldstein T, Chi K, Gleave ME, Graff JN, Beer TM, Drake JM, Evans CP, Aggarwal R, Foye A, Feng FY, Small EJ, Aronson WJ, Freedland SJ, Witte ON, Huang J, Alumkal JJ, Reiter RE, Rettig MB. PMID: 30804427; PMCID: PMC6853839.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    38. Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer. Nat Commun. 2018 11 16; 9(1):4700. Liu C, Lou W, Yang JC, Liu L, Armstrong CM, Lombard AP, Zhao R, Noel ODV, Tepper CG, Chen HW, Dall'Era M, Evans CP, Gao AC. PMID: 30446660; PMCID: PMC6240084.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    39. In honor of Dr. Donald S. Coffey - Prostate cancer biology and therapy. Asian J Urol. 2019 Jan; 6(1):1-2. Gao AC, Mohler JL. PMID: 30775243; PMCID: PMC6363597.
      View in: PubMed   Mentions:
    40. What kind of patients with castration-naïve prostate cancer can benefit from upfront docetaxel and abiraterone: A systematic review and a network meta-analysis. Urol Oncol. 2018 12; 36(12):505-517. Sun G, Zhang X, Chen J, Liao B, Liu Z, Zhao J, Gao AC, Yang Y, Shu K, Liu J, Zhao P, Shen P, Zeng H. PMID: 30316578.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. Current strategies for targeting the activity of androgen receptor variants. Asian J Urol. 2019 Jan; 6(1):42-49. Armstrong CM, Gao AC. PMID: 30775247; PMCID: PMC6363599.
      View in: PubMed   Mentions: 11  
    42. KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC. Oncogene. 2019 01; 38(1):17-32. Wang HJ, Pochampalli M, Wang LY, Zou JX, Li PS, Hsu SC, Wang BJ, Huang SH, Yang P, Yang JC, Chu CY, Hsieh CL, Sung SY, Li CF, Tepper CG, Ann DK, Gao AC, Evans CP, Izumiya Y, Chuu CP, Wang WC, Chen HW, Kung HJ. PMID: 30072740; PMCID: PMC6755995.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    43. Intra versus Inter Cross-resistance Determines Treatment Sequence between Taxane and AR-Targeting Therapies in Advanced Prostate Cancer. Mol Cancer Ther. 2018 10; 17(10):2197-2205. Lombard AP, Liu L, Cucchiara V, Liu C, Armstrong CM, Zhao R, Yang JC, Lou W, Evans CP, Gao AC. PMID: 29891490; PMCID: PMC6168406.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    44. Novel nomograms for castration-resistant prostate cancer and survival outcome in patients with de novo bone metastatic prostate cancer. BJU Int. 2018 12; 122(6):994-1002. Zhao J, Sun G, Liao B, Zhang X, Armstrong CM, Yin X, Liu J, Chen J, Yang Y, Zhao P, Tang Q, Wang Z, Chen Z, Li X, Wei Q, Li X, Chen N, Gao AC, Shen P, Zeng H. PMID: 29772102.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    45. Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting. Eur Urol. 2018 05; 73(5):715-723. Luo J, Attard G, Balk SP, Bevan C, Burnstein K, Cato L, Cherkasov A, De Bono JS, Dong Y, Gao AC, Gleave M, Heemers H, Kanayama M, Kittler R, Lang JM, Lee RJ, Logothetis CJ, Matusik R, Plymate S, Sawyers CL, Selth LA, Soule H, Tilley W, Weigel NL, Zoubeidi A, Dehm SM, Raj GV. PMID: 29258679; PMCID: PMC5929166.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    46. Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer. J Natl Cancer Inst. 2017 Dec 01; 109(12). Wyatt AW, Annala M, Aggarwal R, Beja K, Feng F, Youngren J, Foye A, Lloyd P, Nykter M, Beer TM, Alumkal JJ, Thomas GV, Reiter RE, Rettig MB, Evans CP, Gao AC, Chi KN, Small EJ, Gleave ME. PMID: 29206995; PMCID: PMC6440274.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansCells
    47. Quercetin Targets hnRNPA1 to Overcome Enzalutamide Resistance in Prostate Cancer Cells. Mol Cancer Ther. 2017 Dec; 16(12):2770-2779. Tummala R, Lou W, Gao AC, Nadiminty N. PMID: 28729398; PMCID: PMC5716891.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    48. ABCB1 Mediates Cabazitaxel-Docetaxel Cross-Resistance in Advanced Prostate Cancer. Mol Cancer Ther. 2017 10; 16(10):2257-2266. Lombard AP, Liu C, Armstrong CM, Cucchiara V, Gu X, Lou W, Evans CP, Gao AC. PMID: 28698198; PMCID: PMC5628132.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    49. Androgen Receptor Regulation of Local Growth Hormone in Prostate Cancer Cells. Endocrinology. 2017 07 01; 158(7):2255-2268. Recouvreux MV, Wu JB, Gao AC, Zonis S, Chesnokova V, Bhowmick N, Chung LW, Melmed S. PMID: 28444169; PMCID: PMC5505214.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    50. MicroRNA-181a promotes docetaxel resistance in prostate cancer cells. Prostate. 2017 Jun; 77(9):1020-1028. Armstrong CM, Liu C, Lou W, Lombard AP, Evans CP, Gao AC. PMID: 28485104; PMCID: PMC5448975.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    51. Niclosamide and Bicalutamide Combination Treatment Overcomes Enzalutamide- and Bicalutamide-Resistant Prostate Cancer. Mol Cancer Ther. 2017 08; 16(8):1521-1530. Liu C, Armstrong CM, Lou W, Lombard AP, Cucchiara V, Gu X, Yang JC, Nadiminty N, Pan CX, Evans CP, Gao AC. PMID: 28500234; PMCID: PMC5544572.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    52. CCN3-EZH2-AR feedback loop: new targets for enzalutamide and castration resistant prostate cancer. J Cell Commun Signal. 2017 Mar; 11(1):89-91. Armstrong CM, Gao AC. PMID: 28255661; PMCID: PMC5362580.
      View in: PubMed   Mentions: 5  
    53. Induction of neuroendocrine differentiation in castration resistant prostate cancer cells by adipocyte differentiation-related protein (ADRP) delivered by exosomes. Cancer Lett. 2017 04 10; 391:74-82. Lin LC, Gao AC, Lai CH, Hsieh JT, Lin H. PMID: 28109910.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    54. Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy. Cancers (Basel). 2017 Jan 16; 9(1). Cucchiara V, Yang JC, Mirone V, Gao AC, Rosenfeld MG, Evans CP. PMID: 28275218; PMCID: PMC5295780.
      View in: PubMed   Mentions: 17  
    55. The Molecular Basis of Prostate Carcinogenesis. . 2017 Jan 1; 423-445. Dutt DS, Gao GA. .
      View in: Publisher Site   Mentions:
    56. Inhibition of AKR1C3 Activation Overcomes Resistance to Abiraterone in Advanced Prostate Cancer. Mol Cancer Ther. 2017 01; 16(1):35-44. Liu C, Armstrong CM, Lou W, Lombard A, Evans CP, Gao AC. PMID: 27794047; PMCID: PMC5222693.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    57. Adaptive pathways and emerging strategies overcoming treatment resistance in castration resistant prostate cancer. Asian J Urol. 2016 Oct; 3(4):185-194. Armstrong CM, Gao AC. PMID: 28642838; PMCID: PMC5477778.
      View in: PubMed   Mentions: 14  
    58. Corrigendum: ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat Med. 2016 06 07; 22(6):692. Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. PMID: 27270780.
      View in: PubMed   Mentions: 5     Fields:    
    59. Niclosamide enhances abiraterone treatment via inhibition of androgen receptor variants in castration resistant prostate cancer. Oncotarget. 2016 May 31; 7(22):32210-20. Liu C, Armstrong C, Zhu Y, Lou W, Gao AC. PMID: 27049719; PMCID: PMC5078008.
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    60. ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat Med. 2016 05; 22(5):488-96. Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. PMID: 27019329; PMCID: PMC5030109.
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    61. Lin28 induces resistance to anti-androgens via promotion of AR splice variant generation. Prostate. 2016 Apr; 76(5):445-55. Tummala R, Nadiminty N, Lou W, Evans CP, Gao AC. PMID: 26714839; PMCID: PMC5372699.
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    62. Targeting molecular resistance in castration-resistant prostate cancer. BMC Med. 2015 Sep 01; 13:206. Chandrasekar T, Yang JC, Gao AC, Evans CP. PMID: 26329698; PMCID: PMC4556222.
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    63. Drug resistance in castration resistant prostate cancer: resistance mechanisms and emerging treatment strategies. Am J Clin Exp Urol. 2015; 3(2):64-76. Armstrong CM, Gao AC. PMID: 26309896; PMCID: PMC4539108.
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    64. Stat5a/b in Prostate Cancer Metastasis. Am J Pathol. 2015 Sep; 185(9):2351-3. Gao AC, Zhu Y. PMID: 26187549.
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    65. NF-κB2/p52:c-Myc:hnRNPA1 Pathway Regulates Expression of Androgen Receptor Splice Variants and Enzalutamide Sensitivity in Prostate Cancer. Mol Cancer Ther. 2015 Aug; 14(8):1884-95. Nadiminty N, Tummala R, Liu C, Lou W, Evans CP, Gao AC. PMID: 26056150; PMCID: PMC4529751.
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    66. Mechanisms of resistance in castration-resistant prostate cancer (CRPC). Transl Androl Urol. 2015 Jun; 4(3):365-80. Chandrasekar T, Yang JC, Gao AC, Evans CP. PMID: 26814148; PMCID: PMC4708226.
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    67. Antiandrogens Inhibit ABCB1 Efflux and ATPase Activity and Reverse Docetaxel Resistance in Advanced Prostate Cancer. Clin Cancer Res. 2015 Sep 15; 21(18):4133-42. Zhu Y, Liu C, Armstrong C, Lou W, Sandher A, Gao AC. PMID: 25995342; PMCID: PMC4573793.
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    68. Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition. Prostate. 2015 Sep; 75(13):1341-53. Liu C, Lou W, Armstrong C, Zhu Y, Evans CP, Gao AC. PMID: 25970160; PMCID: PMC4536195.
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    69. Intracrine Androgens and AKR1C3 Activation Confer Resistance to Enzalutamide in Prostate Cancer. Cancer Res. 2015 Apr 01; 75(7):1413-22. Liu C, Lou W, Zhu Y, Yang JC, Nadiminty N, Gaikwad NW, Evans CP, Gao AC. PMID: 25649766; PMCID: PMC4383695.
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    70. Zoledronic acid at the time of castration prevented castration-induced bone metastasis in mice. Endocr Relat Cancer. 2014 Oct; 21(5):C11-4. Ghosh PM, Gao AC. PMID: 25183429.
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    71. Interleukin-6 induces neuroendocrine differentiation (NED) through suppression of RE-1 silencing transcription factor (REST). Prostate. 2014 Aug; 74(11):1086-94. Zhu Y, Liu C, Cui Y, Nadiminty N, Lou W, Gao AC. PMID: 24819501.
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    72. Upregulation of glucose metabolism by NF-κB2/p52 mediates enzalutamide resistance in castration-resistant prostate cancer cells. Endocr Relat Cancer. 2014 Jun; 21(3):435-42. Cui Y, Nadiminty N, Liu C, Lou W, Schwartz CT, Gao AC. PMID: 24659479; PMCID: PMC4021715.
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    73. Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer. Clin Cancer Res. 2014 Jun 15; 20(12):3198-3210. Liu C, Lou W, Zhu Y, Nadiminty N, Schwartz CT, Evans CP, Gao AC. PMID: 24740322; PMCID: PMC4058390.
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    74. Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model. Oncogene. 2014 Sep 04; 33(36):4521-30. Nguyen HG, Yang JC, Kung HJ, Shi XB, Tilki D, Lara PN, DeVere White RW, Gao AC, Evans CP. PMID: 24662833; PMCID: PMC4155805.
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    75. MicroRNAs in the Development and Progression of Prostate Cancer. . 2014 Jan 1; 265-286. Nadiminty NN, Tummala TR, Gao GA. .
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    76. Enhanced anticancer activity of a combination of docetaxel and Aneustat (OMN54) in a patient-derived, advanced prostate cancer tissue xenograft model. Mol Oncol. 2014 Mar; 8(2):311-22. Qu S, Wang K, Xue H, Wang Y, Wu R, Liu C, Gao AC, Gout PW, Collins CC, Wang Y. PMID: 24388358; PMCID: PMC5528545.
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    77. Inhibition of constitutively active Stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells. Prostate. 2014 Feb; 74(2):201-9. Liu C, Zhu Y, Lou W, Cui Y, Evans CP, Gao AC. PMID: 24307657; PMCID: PMC4437226.
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    78. RhoGDIα downregulates androgen receptor signaling in prostate cancer cells. Prostate. 2013 Nov; 73(15):1614-22. Zhu Y, Liu C, Tummala R, Nadiminty N, Lou W, Gao AC. PMID: 23922223; PMCID: PMC3941975.
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    79. Inhibition of ABCB1 expression overcomes acquired docetaxel resistance in prostate cancer. Mol Cancer Ther. 2013 Sep; 12(9):1829-36. Zhu Y, Liu C, Nadiminty N, Lou W, Tummala R, Evans CP, Gao AC. PMID: 23861346; PMCID: PMC3947549.
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    80. Lin28 promotes growth of prostate cancer cells and activates the androgen receptor. Am J Pathol. 2013 Jul; 183(1):288-95. Tummala R, Nadiminty N, Lou W, Zhu Y, Gandour-Edwards R, Chen HW, Evans CP, Gao AC. PMID: 23790802; PMCID: PMC3702743.
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    81. NF-κB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variants. Mol Cancer Ther. 2013 Aug; 12(8):1629-37. Nadiminty N, Tummala R, Liu C, Yang J, Lou W, Evans CP, Gao AC. PMID: 23699654; PMCID: PMC3941973.
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    82. NF-kappaB2/p52 in Prostate Cancer. . 2013 Jan 1; 257-273. Nadiminty NN, Tummala TR, Zhu ZY, Gao GA. .
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    83. Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex. Prostate. 2013 Apr; 73(5):455-66. Duan Z, Zou JX, Yang P, Wang Y, Borowsky AD, Gao AC, Chen HW. PMID: 23038103.
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    84. Functional p53 determines docetaxel sensitivity in prostate cancer cells. Prostate. 2013 Mar; 73(4):418-27. Liu C, Zhu Y, Lou W, Nadiminty N, Chen X, Zhou Q, Shi XB, deVere White RW, Gao AC. PMID: 22996738; PMCID: PMC3938015.
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    85. Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop. Mol Cell Biol. 2012 Aug; 32(15):3121-31. Yang P, Guo L, Duan ZJ, Tepper CG, Xue L, Chen X, Kung HJ, Gao AC, Zou JX, Chen HW. PMID: 22645312; PMCID: PMC3434505.
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    86. MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth. PLoS One. 2012; 7(3):e32832. Nadiminty N, Tummala R, Lou W, Zhu Y, Shi XB, Zou JX, Chen H, Zhang J, Chen X, Luo J, deVere White RW, Kung HJ, Evans CP, Gao AC. PMID: 22479342; PMCID: PMC3316551.
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    87. LNCaP prostate cancer cells with autocrine interleukin-6 expression are resistant to IL-6-induced neuroendocrine differentiation due to increased expression of suppressors of cytokine signaling. Prostate. 2012 Sep 01; 72(12):1306-16. Ge D, Gao AC, Zhang Q, Liu S, Xue Y, You Z. PMID: 22213096; PMCID: PMC3665156.
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    88. MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells. J Biol Chem. 2012 Jan 06; 287(2):1527-37. Nadiminty N, Tummala R, Lou W, Zhu Y, Zhang J, Chen X, eVere White RW, Kung HJ, Evans CP, Gao AC. PMID: 22128178; PMCID: PMC3256915.
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    89. A proteomic approach to elucidate the multiple targets of selenium-induced cell-growth inhibition in human lung cancer. Thorac Cancer. 2011 Nov; 2(4):164-178. Zhong X, Li L, Wang M, Luo W, Tan Q, Xu F, Zhu W, Wang Q, Wang T, Hou M, Nadimity N, Xue X, Chen J, Ma W, Gao AC, Zhou Q. PMID: 27755845.
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    90. Mechanisms of persistent activation of the androgen receptor in CRPC: recent advances and future perspectives. World J Urol. 2012 Jun; 30(3):287-95. Nadiminty N, Gao AC. PMID: 22009116.
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    91. The interleukin 6 receptor is a direct transcriptional target of E2F3 in prostate tumor derived cells. Prostate. 2012 May 01; 72(6):649-60. Libertini SJ, Chen H, al-Bataina B, Koilvaram T, George M, Gao AC, Mudryj M. PMID: 21837779.
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    92. RhoGDIα suppresses growth and survival of prostate cancer cells. Prostate. 2012 Mar; 72(4):392-8. Zhu Y, Tummala R, Liu C, Nadiminty N, Lou W, Evans CP, Zhou Q, Gao AC. PMID: 21681778; PMCID: PMC3961824.
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    93. Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. Prostate. 2012 Jan; 72(1):82-9. Sun M, Liu C, Nadiminty N, Lou W, Zhu Y, Yang J, Evans CP, Zhou Q, Gao AC. PMID: 21538419; PMCID: PMC3938016.
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    94. Intracellular glutathione content influences the sensitivity of lung cancer cell lines to methylseleninic acid. Mol Carcinog. 2012 Apr; 51(4):303-14. Liu C, Liu H, Li Y, Wu Z, Zhu Y, Wang T, Gao AC, Chen J, Zhou Q. PMID: 21520298.
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    95. Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer. Genes Cancer. 2011 Feb; 2(2):151-9. Liu C, Nadiminty N, Tummala R, Chun JY, Lou W, Zhu Y, Sun M, Evans CP, Zhou Q, Gao AC. PMID: 21779488; PMCID: PMC3111248.
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    96. Effects of triclocarban on intact immature male rat: augmentation of androgen action. Reprod Sci. 2011 Feb; 18(2):119-27. Duleba AJ, Ahmed MI, Sun M, Gao AC, Villanueva J, Conley AJ, Turgeon JL, Benirschke K, Gee NA, Chen J, Green PG, Lasley BL. PMID: 20889956; PMCID: PMC3031453.
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    97. The N-terminal kinase suppressor of Ras complex has a weak nucleoside diphosphate kinase activity. Thorac Cancer. 2010 09; 1(3):109-115. Yang X, You J, Luo W, Yue J, Ma L, Xiao W, Zhu D, Wu Z, Wang D, Nadiminty N, Gao AC, Zhou Q. PMID: 27755802.
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    98. Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth. Genes Cancer. 2010 Aug; 1(8):868-76. Chun JY, Tummala R, Nadiminty N, Lou W, Liu C, Yang J, Evans CP, Zhou Q, Gao AC. PMID: 21442031; PMCID: PMC3063649.
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    99. Effect of the specific Src family kinase inhibitor saracatinib on osteolytic lesions using the PC-3 bone model. Mol Cancer Ther. 2010 Jun; 9(6):1629-37. Yang JC, Bai L, Yap S, Gao AC, Kung HJ, Evans CP. PMID: 20484016.
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    100. Aberrant activation of the androgen receptor by NF-kappaB2/p52 in prostate cancer cells. Cancer Res. 2010 Apr 15; 70(8):3309-19. Nadiminty N, Lou W, Sun M, Chen J, Yue J, Kung HJ, Evans CP, Zhou Q, Gao AC. PMID: 20388792; PMCID: PMC3041633.
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    101. Sanguinarine suppresses prostate tumor growth and inhibits survivin expression. Genes Cancer. 2010 Mar; 1(3):283-92. Sun M, Lou W, Chun JY, Cho DS, Nadiminty N, Evans CP, Chen J, Yue J, Zhou Q, Gao AC. PMID: 21318089; PMCID: PMC3036540.
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    102. Microarray analysis reveals potential target genes of NF-kappaB2/p52 in LNCaP prostate cancer cells. Prostate. 2010 Feb 15; 70(3):276-87. Nadiminty N, Dutt S, Tepper C, Gao AC. PMID: 19827050.
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    103. [Combined Inhibition of Vascular Endothelial Growth Factor and Epidermal Growth Factor Signaling Pathways in Non-small Cell Lung Cancer Therapy.]. Zhongguo Fei Ai Za Zhi. 2009 Dec 20; 12(12):1316-24. Nan J, Liu Q, Ding Y, Zhang Z, Gao AC, Zhou Q. PMID: 20723392.
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    104. Molecular mechanisms of castration-resistant prostate cancer progression. Future Oncol. 2009 Nov; 5(9):1403-13. Dutt SS, Gao AC. PMID: 19903068; PMCID: PMC3041149.
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    105. Interleukin-6 regulates androgen synthesis in prostate cancer cells. Clin Cancer Res. 2009 Aug 01; 15(15):4815-22. Chun JY, Nadiminty N, Dutt S, Lou W, Yang JC, Kung HJ, Evans CP, Gao AC. PMID: 19638459; PMCID: PMC3041150.
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    106. Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. Mol Cancer Ther. 2009 Mar; 8(3):665-71. Feng S, Tang Q, Sun M, Chun JY, Evans CP, Gao AC. PMID: 19240160; PMCID: PMC3041173.
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    107. Interleukin-4 activates androgen receptor through CBP/p300. Prostate. 2009 Feb 01; 69(2):126-32. Lee SO, Chun JY, Nadiminty N, Lou W, Feng S, Gao AC. PMID: 18819102; PMCID: PMC3035998.
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    108. Selenium and Androgen Receptor in Prostate Cancer. . 2009 Jan 1; 755-780. Nadiminty NN, Gao GA. .
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    109. NF-kappaB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation. Prostate. 2008 Dec 01; 68(16):1725-33. Nadiminty N, Chun JY, Lou W, Lin X, Gao AC. PMID: 18781579.
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    110. Mechanisms of selenium chemoprevention and therapy in prostate cancer. Mol Nutr Food Res. 2008 Nov; 52(11):1247-60. Nadiminty N, Gao AC. PMID: 18727008.
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    111. Transcriptional regulation of human RANK ligand gene expression by E2F1. Biochem Biophys Res Commun. 2008 Jun 06; 370(3):440-4. Hu Y, Sun M, Nadiminty N, Lou W, Pinder E, Gao AC. PMID: 18381203; PMCID: PMC2950805.
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    112. Lack of expression of androgen receptor may play a critical role in transformation from in situ to invasive basal subtype of high-grade ductal carcinoma of the breast. Hum Pathol. 2008 Mar; 39(3):386-92. Hanley K, Wang J, Bourne P, Yang Q, Gao AC, Lyman G, Tang P. PMID: 18187183.
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    113. Interleukin-4 stimulates androgen-independent growth in LNCaP human prostate cancer cells. Prostate. 2008 Jan 01; 68(1):85-91. Lee SO, Pinder E, Chun JY, Lou W, Sun M, Gao AC. PMID: 18008330.
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    114. Selenium inhibition of survivin expression by preventing Sp1 binding to its promoter. Mol Cancer Ther. 2007 Sep; 6(9):2572-80. Chun JY, Hu Y, Pinder E, Wu J, Li F, Gao AC. PMID: 17876054; PMCID: PMC2821810.
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    115. Development of an androgen-deprivation induced and androgen suppressed human prostate cancer cell line. Prostate. 2007 Sep 01; 67(12):1293-300. Lee SO, Dutt SS, Nadiminty N, Pinder E, Liao H, Gao AC. PMID: 17626246.
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    116. LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway. Biochem Biophys Res Commun. 2007 Jul 27; 359(2):379-84. Nadiminty N, Chun JY, Hu Y, Dutt S, Lin X, Gao AC. PMID: 17543278; PMCID: PMC2062522.
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    117. Interleukin-6 undergoes transition from growth inhibitor associated with neuroendocrine differentiation to stimulator accompanied by androgen receptor activation during LNCaP prostate cancer cell progression. Prostate. 2007 May 15; 67(7):764-73. Lee SO, Chun JY, Nadiminty N, Lou W, Gao AC. PMID: 17373716.
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    118. Monomethylated selenium inhibits growth of LNCaP human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA). Prostate. 2006 Jul 01; 66(10):1070-5. Lee SO, Yeon Chun J, Nadiminty N, Trump DL, Ip C, Dong Y, Gao AC. PMID: 16637076.
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    119. Hypoxia increases androgen receptor activity in prostate cancer cells. Cancer Res. 2006 May 15; 66(10):5121-9. Park SY, Kim YJ, Gao AC, Mohler JL, Onate SA, Hidalgo AA, Ip C, Park EM, Yoon SY, Park YM. PMID: 16707435.
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    120. Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7264-9. Nadiminty N, Lou W, Lee SO, Lin X, Trump DL, Gao AC. PMID: 16651533; PMCID: PMC1464331.
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    121. [Primary experimental results of methylseleninic acid on the proliferation inhibition and apoptotic induction in human high-metastatic large cell lung cancer cell line L9981]. Zhongguo Fei Ai Za Zhi. 2006 Apr 20; 9(2):103-8. Liu J, Zhong X, Zhou Q, Gao AC, Wang Y, Zhu W, Ma L, Zhang Z. PMID: 21144291.
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    122. Mechanisms of selenium down-regulation of androgen receptor signaling in prostate cancer. Mol Cancer Ther. 2006 Apr; 5(4):913-8. Chun JY, Nadiminty N, Lee SO, Onate SA, Lou W, Gao AC. PMID: 16648561.
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    123. Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. Clin Cancer Res. 2006 Mar 01; 12(5):1420-30. Nadiminty N, Lou W, Lee SO, Mehraein-Ghomi F, Kirk JS, Conroy JM, Zhang H, Gao AC. PMID: 16533764.
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    124. CHAPTER 33 Selenium and Cancer Prevention. . 2006 Jan 1; 573-581. IP IC, MARSHALL MJ, PARK PY, ZHANG ZH, DONG DY, WU WY, GAO GA. .
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    125. Interleukin-6 polymorphism is associated with more aggressive prostate cancer. J Urol. 2005 Aug; 174(2):753-6. Tan D, Wu X, Hou M, Lee SO, Lou W, Wang J, Janarthan B, Nallapareddy S, Trump DL, Gao AC. PMID: 16006970.
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    126. Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers. Mol Cancer Ther. 2005 Jul; 4(7):1047-55. Dong Y, Zhang H, Gao AC, Marshall JR, Ip C. PMID: 16020662.
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    127. Requirement for NF-(kappa)B in interleukin-4-induced androgen receptor activation in prostate cancer cells. Prostate. 2005 Jul 01; 64(2):160-7. Lee SO, Lou W, Nadiminty N, Lin X, Gao AC. PMID: 15678501.
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    128. Selenium disrupts estrogen signaling by altering estrogen receptor expression and ligand binding in human breast cancer cells. Cancer Res. 2005 Apr 15; 65(8):3487-92. Lee SO, Nadiminty N, Wu XX, Lou W, Dong Y, Ip C, Onate SA, Gao AC. PMID: 15833885.
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    129. Microarray Data Mining for Potential Selenium Targets in Chemoprevention of Prostate Cancer. Cancer Genomics Proteomics. 2005 Apr; 2(2):97-114. Zhang H, Dong Y, Zhao H, Brooks JD, Hawthorn L, Nowak N, Marshall JR, Gao AC, Ip C. PMID: 18548127; PMCID: PMC2424238.
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    130. Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer. Nat Genet. 2005 Apr; 37(4):407-12. Sun X, Frierson HF, Chen C, Li C, Ran Q, Otto KB, Cantarel BL, Cantarel BM, Vessella RL, Gao AC, Petros J, Miura Y, Simons JW, Dong JT. PMID: 15750593.
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    131. STAT3 and transactivation of steroid hormone receptors. Vitam Horm. 2005; 70:333-57. Lee SO, Gao AC. PMID: 15727810.
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    132. RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells. Prostate. 2004 Sep 01; 60(4):303-9. Lee SO, Lou W, Qureshi KM, Mehraein-Ghomi F, Trump DL, Gao AC. PMID: 15264241.
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    133. Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway. Prostate. 2004 Aug 01; 60(3):178-86. Lee SO, Lou W, Johnson CS, Trump DL, Gao AC. PMID: 15176047.
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    134. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene. 2004 Apr 29; 23(20):3550-60. Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, Huang S. PMID: 15116091.
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    135. Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res. 2004 Jan 01; 64(1):19-22. Dong Y, Lee SO, Zhang H, Marshall J, Gao AC, Ip C. PMID: 14729601.
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    136. Defining regulatory elements in the human KAI1 (CD 82) metastasis suppressor gene. Prostate. 2003 Dec 01; 57(4):256-60. Gao AC, Lou W, Dong JT, Barrett JC, Danielpour D, Isaacs JT. PMID: 14601021.
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