Nicholas Mitsiades

Title(s)Professor in Residence, MED: Int Med Hematology/Oncology
SchoolSchool of Medicine
Address4501 X Street, Suite 3016
CA 95817
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    1. Editorial Expression of Concern: Activation of NF-κB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene. 2024 Nov 11. Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, Anderson KC. PMID: 39528816.
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    2. PINK1-Mediated Mitochondrial Activity Confers Olaparib Resistance in Prostate Cancer Cells. Cancer Res Commun. 2024 Oct 23. Schaaf ZA, Ning S, Leslie AR, Sharifi M, Gao RY, Maine JP, Lou W, Lombard AP, Liu C, Yu AM, Mitsiades N, Gao AC. PMID: 39440945.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming. Proc Natl Acad Sci U S A. 2024 Oct 15; 121(42):e2411321121. Yang Y, Zhang X, Cai D, Zheng X, Zhao X, Zou JX, Zhang J, Borowsky AD, Dall'Era MA, Corey E, Mitsiades N, Kung HJ, Chen X, Li JJ, Downes M, Evans RM, Chen HW. PMID: 39383000.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. LX1 Targets Androgen Receptor Variants and AKR1C3 to overcome Therapy Resistance in Advanced Prostate Cancer. Cancer Res. 2024 Aug 01. Ning S, Armstrong CM, Xing E, Leslie AR, Gao RY, Sharifi M, Schaaf ZA, Lou W, Han X, Xu DH, Yang R, Cheng J, Mohammed S, Mitsiades N, Liu C, Lombard AP, Wu CY, Cheng X, Li PK, Gao AC. PMID: 39088701.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis. Cancer Res. 2024 07 02; 84(13):2060-2072. White BS, Woo XY, Koc S, Sheridan T, Neuhauser SB, Wang S, Evrard YA, Chen L, Foroughi Pour A, Landua JD, Mashl RJ, Davies SR, Fang B, Raso MG, Evans KW, Bailey MH, Chen Y, Xiao M, Rubinstein JC, Sanderson BJ, Lloyd MW, Domanskyi S, Dobrolecki LE, Fujita M, Fujimoto J, Xiao G, Fields RC, Mudd JL, Xu X, Hollingshead MG, Jiwani S, Acevedo S, PDXNet Consortium, Davis-Dusenbery BN, Robinson PN, Moscow JA, Doroshow JH, Mitsiades N, Kaochar S, Pan CX, Carvajal-Carmona LG, Welm AL, Welm BE, Govindan R, Li S, Davies MA, Roth JA, Meric-Bernstam F, Xie Y, Herlyn M, Ding L, Lewis MT, Bult CJ, Dean DA, Chuang JH. PMID: 39082680; PMCID: PMC11217732.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. Assessment of Patient-Derived Xenograft Growth and Antitumor Activity: The NCI PDXNet Consensus Recommendations. Mol Cancer Ther. 2024 Jul 02; 23(7):924-938. Meric-Bernstam F, Lloyd MW, Koc S, Evrard YA, McShane LM, Lewis MT, Evans KW, Li D, Rubinstein L, Welm A, Dean DA, Srivastava A, Grover JW, Ha MJ, Chen H, Huang X, Varadarajan K, Wang J, Roth JA, Welm B, Govinden R, Ding L, Kaochar S, Mitsiades N, Carvajal-Carmona L, Herylyn M, Davies MA, Shapiro GI, Fields R, Trevino JG, Harrell JC, NCI PDXNet Consortium, Doroshow JH, Chuang JH, Moscow JA. PMID: 38641411; PMCID: PMC11217730.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    7. Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2024 Feb 13; 121(7):e2314085121. Kelly AG, Wang W, Rothenberger E, Yang J, Gilligan MM, Kipper FC, Attaya A, Gartung A, Hwang SH, Gillespie MJ, Bayer RL, Quinlivan KM, Torres KL, Huang S, Mitsiades N, Yang H, Hammock BD, Panigrahy D. PMID: 38330013; PMCID: PMC10873624.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    8. Incidental detection of FGFR3 fusion via liquid biopsy leading to earlier diagnosis of urothelial carcinoma. NPJ Precis Oncol. 2023 Nov 18; 7(1):123. Huang Q, Mitsiades I, Dowst H, Zarrin-Khameh N, Noor AB, Castro P, Scheurer ME, Godoy G, Mims MP, Mitsiades N. PMID: 37980380; PMCID: PMC10657397.
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    9. The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response. Cancer Res. 2022 08 16; 82(16):2848-2859. Berchuck JE, Adib E, Abou Alaiwi S, Dash AK, Shin JN, Lowder D, McColl C, Castro P, Carelli R, Benedetti E, Deng J, Robertson M, Baca SC, Bell C, McClure HM, El Zarif T, Davidsohn MP, Lakshminarayanan G, Rizwan K, Skapura DG, Grimm SL, Davis CM, Ehli EA, Kelleher KM, Seo JH, Mitsiades N, Coarfa C, Pomerantz MM, Loda M, Ittmann M, Freedman ML, Kaochar S. PMID: 35731919; PMCID: PMC9379363.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    10. PDXNet portal: patient-derived Xenograft model, data, workflow and tool discovery. NAR Cancer. 2022 Jun; 4(2):zcac014. Koc S, Lloyd MW, Grover JW, Xiao N, Seepo S, Subramanian SL, Ray M, Frech C, DiGiovanna J, Webster P, Neuhauser S, Srivastava A, Woo XY, Sanderson BJ, White B, Lott P, Dobrolecki LE, Dowst H, PDXNet Consortium , Evrard YA, Wallace TA, Moscow JA, Doroshow JH, Mitsiades N, Kaochar S, Pan CX, Chen MS, Carvajal-Carmona L, Welm AL, Welm BE, Lewis MT, Govindan R, Ding L, Li S, Herlyn M, Davies MA, Roth J, Meric-Bernstam F, Robinson PN, Bult CJ, Davis-Dusenbery B, Dean DA, Chuang JH. PMID: 35475145; PMCID: PMC9026194.
      View in: PubMed   Mentions: 7  
    11. Racial disparities in prostate cancer: A complex interplay between socioeconomic inequities and genomics. Cancer Lett. 2022 04 10; 531:71-82. Lowder D, Rizwan K, McColl C, Paparella A, Ittmann M, Mitsiades N, Kaochar S. PMID: 35122875; PMCID: PMC9701576.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    12. Inhibition of GATA2 in prostate cancer by a clinically available small molecule. Endocr Relat Cancer. 2021 11 24; 29(1):15-31. Kaochar S, Rusin A, Foley C, Rajapakshe K, Robertson M, Skapura D, Mason C, Berman De Ruiz K, Tyryshkin AM, Deng J, Shin JN, Fiskus W, Dong J, Huang S, Navone NM, Davis CM, Ehli EA, Coarfa C, Mitsiades N. PMID: 34636746; PMCID: PMC8634153.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    13. Transcriptional Reprogramming Differentiates Active from Inactive ESR1 Fusions in Endocrine Therapy-Refractory Metastatic Breast Cancer. Cancer Res. 2021 12 15; 81(24):6259-6272. Gou X, Anurag M, Lei JT, Kim BJ, Singh P, Seker S, Fandino D, Han A, Rehman S, Hu J, Korchina V, Doddapaneni H, Dobrolecki LE, Mitsiades N, Lewis MT, Welm AL, Li S, Lee AV, Robinson DR, Foulds CE, Ellis MJ. PMID: 34711608; PMCID: PMC9234971.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    14. Androgen receptor signaling inhibitors: post-chemotherapy, pre-chemotherapy and now in castration-sensitive prostate cancer. Endocr Relat Cancer. 2021 07 15; 28(8):T19-T38. Mitsiades N, Kaochar S. PMID: 34128827.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    15. Re: Umang Swami, Pedro Isaacsson Velho, Roberto Nussenzveig, et al. Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer. Eur Urol 2020;78:652-6: Can Mutant SPOP Become an Actionable Biomarker for Precision Oncology Management of Prostate Cancer? Eur Urol. 2021 03; 79(3):e91-e93. Kaochar S, Mitsiades N. PMID: 33358624.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Pleiotropic Mechanisms Drive Endocrine Resistance in the Three-Dimensional Bone Microenvironment. Cancer Res. 2021 01 15; 81(2):371-383. Dhimolea E, de Matos Simoes R, Kansara D, Weng X, Sharma S, Awate P, Liu Z, Gao D, Mitsiades N, Schwab JH, Chen Y, Jeselsohn R, Culhane AC, Brown M, Georgakoudi I, Mitsiades CS. PMID: 32859606; PMCID: PMC8445072.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. Discovery, Structure-Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP. J Med Chem. 2020 05 14; 63(9):4716-4731. Wu F, Hua Y, Kaochar S, Nie S, Lin YL, Yao Y, Wu J, Wu X, Fu X, Schiff R, Davis CM, Robertson M, Ehli EA, Coarfa C, Mitsiades N, Song Y. PMID: 32314924; PMCID: PMC7340344.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    18. Glucocorticoids mediate adverse events of deep androgen receptor axis inhibition in prostate cancer patients. Ann Oncol. 2020 03; 31(3):323-325. Kaochar S, Mitsiades N. PMID: 32067673.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer. Transl Cancer Res. 2019 Mar; 8(Suppl 2):S198-S203. Kaochar S, Mitsiades N. PMID: 31360645; PMCID: PMC6662936.
      View in: PubMed   Mentions: 3  
    20. Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer. Nat Metab. 2019 01; 1(1):70-85. Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha PK, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, O'Malley BW, Putluri N, McGuire SE. PMID: 31198906; PMCID: PMC6563330.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    21. Harnessing Androgen Receptor Pathway Activation for Targeted Alpha Particle Radioimmunotherapy of Breast Cancer. Clin Cancer Res. 2019 01 15; 25(2):881-891. Thorek DLJ, Ku AT, Mitsiades N, Veach D, Watson PA, Metha D, Strand SE, Sharma SK, Lewis JS, Abou DS, Lilja HG, Larson SM, McDevitt MR, Ulmert D. PMID: 30254080; PMCID: PMC6524527.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    22. A Novel Mechanism to Drive Castration-Resistant Prostate Cancer. Trends Endocrinol Metab. 2018 06; 29(6):366-368. Kaochar S, Mitsiades N. PMID: 29605661; PMCID: PMC5960430.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    23. ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells. Invest Ophthalmol Vis Sci. 2018 01 01; 59(1):132-143. Kaochar S, Dong J, Torres M, Rajapakshe K, Nikolos F, Davis CM, Ehli EA, Coarfa C, Mitsiades N, Poulaki V. PMID: 29332125; PMCID: PMC5769500.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    24. Abiraterone Acetate for Metastatic Prostate Cancer in Patients With Suboptimal Biochemical Response to Hormone Induction. JAMA Oncol. 2017 Nov 09; 3(11):e170231. Flaig TW, Plets M, Hussain MHA, Agarwal N, Mitsiades N, Deshpande HA, Vaishampayan UN, Thompson IM. PMID: 28358937; PMCID: PMC5824213.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    25. SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein. Oncogene. 2017 08 17; 36(33):4767-4777. Geng C, Kaochar S, Li M, Rajapakshe K, Fiskus W, Dong J, Foley C, Dong B, Zhang L, Kwon OJ, Shah SS, Bolaki M, Xin L, Ittmann M, O'Malley BW, Coarfa C, Mitsiades N. PMID: 28414305; PMCID: PMC5887163.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    26. Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation. Cancer Lett. 2017 01 28; 385:207-214. Wu F, Dai X, Gan W, Wan L, Li M, Mitsiades N, Wei W, Ding Q, Zhang J. PMID: 27780719; PMCID: PMC5148662.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    27. The essential role of GATA transcription factors in adult murine prostate. Oncotarget. 2016 Jul 26; 7(30):47891-47903. Xiao L, Feng Q, Zhang Z, Wang F, Lydon JP, Ittmann MM, Xin L, Mitsiades N, He B. PMID: 27374105; PMCID: PMC5216986.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    28. Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer. Nat Commun. 2016 05 19; 7:11612. Kaushik AK, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, Zaslavsky A, Putluri V, Vasu VT, Zhang Y, Khan AS, Lloyd S, Szafran AT, Dasgupta S, Bader DA, Stossi F, Li H, Samanta S, Cao X, Tsouko E, Huang S, Frigo DE, Chan L, Edwards DP, Kaipparettu BA, Mitsiades N, Weigel NL, Mancini M, McGuire SE, Mehra R, Ittmann MM, Chinnaiyan AM, Putluri N, Palapattu GS, Michailidis G, Sreekumar A. PMID: 27194471; PMCID: PMC4874037.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    29. HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes. Cancer Res. 2016 Mar 15; 76(6):1463-75. Nikolai BC, Lanz RB, York B, Dasgupta S, Mitsiades N, Creighton CJ, Tsimelzon A, Hilsenbeck SG, Lonard DM, Smith CL, O'Malley BW. PMID: 26833126; PMCID: PMC4794399.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    30. Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer. Horm Cancer. 2016 Apr; 7(2):84-103. Foley C, Mitsiades N. PMID: 26728473; PMCID: PMC5380740.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    31. B-Raf Inhibition in the Clinic: Present and Future. Annu Rev Med. 2016; 67:29-43. Fiskus W, Mitsiades N. PMID: 26768236.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    32. Comprehensive proteomic profiling identifies the androgen receptor axis and other signaling pathways as targets of microRNAs suppressed in metastatic prostate cancer. Oncogene. 2016 05 05; 35(18):2345-56. Coarfa C, Fiskus W, Eedunuri VK, Rajapakshe K, Foley C, Chew SA, Shah SS, Geng C, Shou J, Mohamed JS, O'Malley BW, Mitsiades N. PMID: 26364608; PMCID: PMC5915337.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    33. miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation. Mol Endocrinol. 2015 Aug; 29(8):1170-83. Eedunuri VK, Rajapakshe K, Fiskus W, Geng C, Chew SA, Foley C, Shah SS, Shou J, Mohamed JS, Coarfa C, O'Malley BW, Mitsiades N. PMID: 26066330; PMCID: PMC4518002.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    34. Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis. J Clin Invest. 2015 Mar 02; 125(3):1174-88. Dasgupta S, Putluri N, Long W, Zhang B, Wang J, Kaushik AK, Arnold JM, Bhowmik SK, Stashi E, Brennan CA, Rajapakshe K, Coarfa C, Mitsiades N, Ittmann MM, Chinnaiyan AM, Sreekumar A, O'Malley BW. PMID: 25664849; PMCID: PMC4362260.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    35. GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18261-6. He B, Lanz RB, Fiskus W, Geng C, Yi P, Hartig SM, Rajapakshe K, Shou J, Wei L, Shah SS, Foley C, Chew SA, Eedunuri VK, Bedoya DJ, Feng Q, Minami T, Mitsiades CS, Frolov A, Weigel NL, Hilsenbeck SG, Rosen DG, Palzkill T, Ittmann MM, Song Y, Coarfa C, O'Malley BW, Mitsiades N. PMID: 25489091; PMCID: PMC4280633.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    36. Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer. Cancer Res. 2014 Oct 01; 74(19):5631-43. Geng C, Rajapakshe K, Shah SS, Shou J, Eedunuri VK, Foley C, Fiskus W, Rajendran M, Chew SA, Zimmermann M, Bond R, He B, Coarfa C, Mitsiades N. PMID: 25274033; PMCID: PMC4209379.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    37. An epigenomic approach to therapy for tamoxifen-resistant breast cancer. Cell Res. 2014 Jul; 24(7):809-19. Feng Q, Zhang Z, Shea MJ, Creighton CJ, Coarfa C, Hilsenbeck SG, Lanz R, He B, Wang L, Fu X, Nardone A, Song Y, Bradner J, Mitsiades N, Mitsiades CS, Osborne CK, Schiff R, O'Malley BW. PMID: 24874954; PMCID: PMC4085766.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    38. Protein kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation. Invest Ophthalmol Vis Sci. 2014 Apr 07; 55(4):2130-9. Cerne JZ, Hartig SM, Hamilton MP, Chew SA, Mitsiades N, Poulaki V, McGuire SE. PMID: 24595385; PMCID: PMC3979518.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    39. Metabolomic profiling identifies biochemical pathways associated with castration-resistant prostate cancer. J Proteome Res. 2014 Feb 07; 13(2):1088-100. Kaushik AK, Vareed SK, Basu S, Putluri V, Putluri N, Panzitt K, Brennan CA, Chinnaiyan AM, Vergara IA, Erho N, Weigel NL, Mitsiades N, Shojaie A, Palapattu G, Michailidis G, Sreekumar A. PMID: 24359151; PMCID: PMC3975657.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    40. A road map to comprehensive androgen receptor axis targeting for castration-resistant prostate cancer. Cancer Res. 2013 Aug 01; 73(15):4599-605. Mitsiades N. PMID: 23887973.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    41. Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6997-7002. Geng C, He B, Xu L, Barbieri CE, Eedunuri VK, Chew SA, Zimmermann M, Bond R, Shou J, Li C, Blattner M, Lonard DM, Demichelis F, Coarfa C, Rubin MA, Zhou P, O'Malley BW, Mitsiades N. PMID: 23559371; PMCID: PMC3637757.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    42. Clinical appraisal of abiraterone in the treatment of metastatic prostatic cancer: patient considerations, novel opportunities, and future directions. Onco Targets Ther. 2013; 6:9-18. Bedoya DJ, Mitsiades N. PMID: 23319868; PMCID: PMC3540953.
      View in: PubMed   Mentions: 2  
    43. Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors. Cancer Res. 2012 Dec 01; 72(23):6142-52. Mitsiades N, Sung CC, Schultz N, Danila DC, He B, Eedunuri VK, Fleisher M, Sander C, Sawyers CL, Scher HI. PMID: 22971343; PMCID: PMC3685485.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansCells
    44. Abiraterone acetate, a first-in-class CYP17 inhibitor, establishes a new treatment paradigm in castration-resistant prostate cancer. Expert Rev Anticancer Ther. 2012 Jan; 12(1):1-3. Bedoya DJ, Mitsiades N. PMID: 22149426.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    45. Circulating adiponectin is inversely associated with risk of thyroid cancer: in vivo and in vitro studies. J Clin Endocrinol Metab. 2011 Dec; 96(12):E2023-8. Mitsiades N, Pazaitou-Panayiotou K, Aronis KN, Moon HS, Chamberland JP, Liu X, Diakopoulos KN, Kyttaris V, Panagiotou V, Mylvaganam G, Tseleni-Balafouta S, Mantzoros CS. PMID: 21937620; PMCID: PMC3232611.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    46. Genotype-dependent sensitivity of uveal melanoma cell lines to inhibition of B-Raf, MEK, and Akt kinases: rationale for personalized therapy. Invest Ophthalmol Vis Sci. 2011 Sep 14; 52(10):7248-55. Mitsiades N, Chew SA, He B, Riechardt AI, Karadedou T, Kotoula V, Poulaki V. PMID: 21828154; PMCID: PMC3207725.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    47. Integrative genomic profiling of human prostate cancer. Cancer Cell. 2010 Jul 13; 18(1):11-22. Taylor BS, Schultz N, Hieronymus H, Gopalan A, Xiao Y, Carver BS, Arora VK, Kaushik P, Cerami E, Reva B, Antipin Y, Mitsiades N, Landers T, Dolgalev I, Major JE, Wilson M, Socci ND, Lash AE, Heguy A, Eastham JA, Scher HI, Reuter VE, Scardino PT, Sander C, Sawyers CL, Gerald WL. PMID: 20579941; PMCID: PMC3198787.
      View in: PubMed   Mentions: 2125     Fields:    Translation:HumansAnimalsCells
    48. Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity. Nat Med. 2010 Apr; 16(4):483-9. McMillin DW, Delmore J, Weisberg E, Negri JM, Geer DC, Klippel S, Mitsiades N, Schlossman RL, Munshi NC, Kung AL, Griffin JD, Richardson PG, Anderson KC, Mitsiades CS. PMID: 20228816; PMCID: PMC3786785.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansCells
    49. A T cell-binding fragment of fibrinogen can prevent autoimmunity. J Autoimmun. 2010 Jun; 34(4):453-9. Takada Y, Ono Y, Saegusa J, Sagusa J, Mitsiades C, Mitsiades N, Tsai J, He Y, Maningding E, Coleman A, Ramirez-Maverakis D, Rodrigues R, Rodriquez R, Takada Y, Maverakis E. PMID: 20036106; PMCID: PMC2860040.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    50. Interactions of the Hdm2/p53 and proteasome pathways may enhance the antitumor activity of bortezomib. Clin Cancer Res. 2009 Dec 01; 15(23):7153-60. Ooi MG, Hayden PJ, Kotoula V, McMillin DW, Charalambous E, Daskalaki E, Raje NS, Munshi NC, Chauhan D, Hideshima T, Buon L, Clynes M, O'Gorman P, Richardson PG, Mitsiades CS, Anderson KC, Mitsiades N. PMID: 19934289; PMCID: PMC3672410.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    51. In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465. Br J Haematol. 2009 Dec; 147(5):672-6. Negri JM, McMillin DW, Delmore J, Mitsiades N, Hayden P, Klippel S, Hideshima T, Chauhan D, Munshi NC, Buser CA, Pollard J, Richardson PG, Anderson KC, Mitsiades CS. PMID: 19751238; PMCID: PMC3672411.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    52. Role of alpha 4 integrin (CD49d) in the pathogenesis of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4898-904. Iliaki E, Poulaki V, Mitsiades N, Mitsiades CS, Miller JW, Gragoudas ES. PMID: 19553613.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    53. Molecular sequelae of histone deacetylase inhibition in human retinoblastoma cell lines: clinical implications. Invest Ophthalmol Vis Sci. 2009 Sep; 50(9):4072-9. Poulaki V, Mitsiades CS, Kotoula V, Negri J, McMullan C, Miller JW, Marks PA, Mitsiades N. PMID: 19387079.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    54. Mutational analysis of the BRAF, RAS and EGFR genes in human adrenocortical carcinomas. Endocr Relat Cancer. 2009 Jun; 16(2):565-72. Kotoula V, Sozopoulos E, Litsiou H, Fanourakis G, Koletsa T, Voutsinas G, Tseleni-Balafouta S, Mitsiades CS, Wellmann A, Mitsiades N. PMID: 19190079.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    55. Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study. Cancer Causes Control. 2009 Jul; 20(5):625-33. Dalamaga M, Migdalis I, Fargnoli JL, Papadavid E, Bloom E, Mitsiades N, Karmaniolas K, Pelecanos N, Tseleni-Balafouta S, Dionyssiou-Asteriou A, Mantzoros CS. PMID: 19051043; PMCID: PMC2720089.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    56. Cognitive effects of hormonal therapy in older adults. Semin Oncol. 2008 Dec; 35(6):569-81. Mitsiades N, Correa D, Gross CP, Hurria A, Slovin SF. PMID: 19027461.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    57. Molecular pathology of thyroid cancer: diagnostic and clinical implications. Best Pract Res Clin Endocrinol Metab. 2008 Dec; 22(6):955-69. Fagin JA, Mitsiades N. PMID: 19041825; PMCID: PMC2615540.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    58. Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo. Cancer Res. 2008 Jul 01; 68(13):5216-25. Mitsiades CS, Ocio EM, Pandiella A, Maiso P, Gajate C, Garayoa M, Vilanova D, Montero JC, Mitsiades N, McMullan CJ, Munshi NC, Hideshima T, Chauhan D, Aviles P, Otero G, Faircloth G, Mateos MV, Richardson PG, Mollinedo F, San-Miguel JF, Anderson KC. PMID: 18593922.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    59. Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: two case-control studies. Oncology. 2007; 73(3-4):261-9. Petridou ET, Mitsiades N, Gialamas S, Angelopoulos M, Skalkidou A, Dessypris N, Hsi A, Lazaris N, Polyzos A, Syrigos C, Brennan AM, Tseleni-Balafouta S, Mantzoros CS. PMID: 18424891.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    60. Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors. Endocr Relat Cancer. 2008 Mar; 15(1):289-99. Williams CJ, Mitsiades N, Sozopoulos E, Hsi A, Wolk A, Nifli AP, Tseleni-Balafouta S, Mantzoros CS. PMID: 18310295.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    61. The proteasome inhibitor bortezomib induces apoptosis in human retinoblastoma cell lines in vitro. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4706-19. Poulaki V, Mitsiades CS, Kotoula V, Negri J, McMillin D, Miller JW, Mitsiades N. PMID: 17898295.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    62. Bcl-2 overexpression in thyroid carcinoma cells increases sensitivity to Bcl-2 homology 3 domain inhibition. J Clin Endocrinol Metab. 2007 Dec; 92(12):4845-52. Mitsiades CS, Hayden P, Kotoula V, McMillin DW, McMullan C, Negri J, Delmore JE, Poulaki V, Mitsiades N. PMID: 17848408.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    63. Multiple myeloma: a prototypic disease model for the characterization and therapeutic targeting of interactions between tumor cells and their local microenvironment. J Cell Biochem. 2007 Jul 01; 101(4):950-68. Mitsiades CS, Mitsiades NS, Richardson PG, Munshi NC, Anderson KC. PMID: 17546631.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    64. Thymoma-associated multiorgan autoimmunity: a graft-versus-host-like disease. J Am Acad Dermatol. 2007 Oct; 57(4):683-9. Wadhera A, Maverakis E, Mitsiades N, Lara PN, Fung MA, Lynch PJ. PMID: 17433850.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    65. Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis. FASEB J. 2007 Jul; 21(9):2113-23. Poulaki V, Iliaki E, Mitsiades N, Mitsiades CS, Paulus YN, Bula DV, Gragoudas ES, Miller JW. PMID: 17400913.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    66. Targeting BRAFV600E in thyroid carcinoma: therapeutic implications. Mol Cancer Ther. 2007 Mar; 6(3):1070-8. Mitsiades CS, Negri J, McMullan C, McMillin DW, Sozopoulos E, Fanourakis G, Voutsinas G, Tseleni-Balafouta S, Poulaki V, Batt D, Mitsiades N. PMID: 17363500.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    67. Serum adiponectin concentrations and tissue expression of adiponectin receptors are reduced in patients with prostate cancer: a case control study. Cancer Epidemiol Biomarkers Prev. 2007 Feb; 16(2):308-13. Michalakis K, Williams CJ, Mitsiades N, Blakeman J, Balafouta-Tselenis S, Giannopoulos A, Mantzoros CS. PMID: 17301264.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    68. Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies. J Clin Endocrinol Metab. 2007 Mar; 92(3):1041-8. Körner A, Pazaitou-Panayiotou K, Kelesidis T, Kelesidis I, Williams CJ, Kaprara A, Bullen J, Neuwirth A, Tseleni S, Mitsiades N, Kiess W, Mantzoros CS. PMID: 17192291.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    69. Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM). Blood. 2007 Feb 01; 109(3):1220-7. Chauhan D, Neri P, Velankar M, Podar K, Hideshima T, Fulciniti M, Tassone P, Raje N, Mitsiades C, Mitsiades N, Richardson P, Zawel L, Tran M, Munshi N, Anderson KC. PMID: 17032924; PMCID: PMC1785138.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    70. Proteasome inhibition as a new therapeutic principle in hematological malignancies. Curr Drug Targets. 2006 Oct; 7(10):1341-7. Mitsiades CS, Mitsiades N, Hideshima T, Richardson PG, Anderson KC. PMID: 17073596.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    71. Antitumor effects of the proteasome inhibitor bortezomib in medullary and anaplastic thyroid carcinoma cells in vitro. J Clin Endocrinol Metab. 2006 Oct; 91(10):4013-21. Mitsiades CS, McMillin D, Kotoula V, Poulaki V, McMullan C, Negri J, Fanourakis G, Tseleni-Balafouta S, Ain KB, Mitsiades N. PMID: 16849420.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    72. Epidermal growth factor receptor as a therapeutic target in human thyroid carcinoma: mutational and functional analysis. J Clin Endocrinol Metab. 2006 Sep; 91(9):3662-6. Mitsiades CS, Kotoula V, Poulaki V, Sozopoulos E, Negri J, Charalambous E, Fanourakis G, Voutsinas G, Tseleni-Balafouta S, Mitsiades N. PMID: 16822827.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    73. Fas signaling in thyroid carcinomas is diverted from apoptosis to proliferation. Clin Cancer Res. 2006 Jun 15; 12(12):3705-12. Mitsiades CS, Poulaki V, Fanourakis G, Sozopoulos E, McMillin D, Wen Z, Voutsinas G, Tseleni-Balafouta S, Mitsiades N. PMID: 16778096.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    74. The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: interplay of growth factors, their receptors and stromal interactions. Eur J Cancer. 2006 Jul; 42(11):1564-73. Mitsiades CS, Mitsiades NS, Munshi NC, Richardson PG, Anderson KC. PMID: 16765041.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    75. Antimyeloma activity of heat shock protein-90 inhibition. Blood. 2006 Feb 01; 107(3):1092-100. Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Kung AL, Davies FE, Morgan G, Akiyama M, Shringarpure R, Munshi NC, Richardson PG, Hideshima T, Chauhan D, Gu X, Bailey C, Joseph M, Libermann TA, Rosen NS, Anderson KC. PMID: 16234364; PMCID: PMC1895907.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    76. A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells. Cancer Res. 2005 Sep 15; 65(18):8350-8. Chauhan D, Li G, Podar K, Hideshima T, Neri P, He D, Mitsiades N, Richardson P, Chang Y, Schindler J, Carver B, Anderson KC. PMID: 16166312.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    77. Proteasome inhibition as a therapeutic strategy for hematologic malignancies. Expert Rev Anticancer Ther. 2005 Jun; 5(3):465-76. Mitsiades CS, Mitsiades N, Hideshima T, Richardson PG, Anderson KC. PMID: 16001954.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    78. Treatment of hematologic malignancies and solid tumors by inhibiting IGF receptor signaling. Expert Rev Anticancer Ther. 2005 Jun; 5(3):487-99. Mitsiades CS, Mitsiades N. PMID: 16001956.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    79. Novel histone deacetylase inhibitors in the treatment of thyroid cancer. Clin Cancer Res. 2005 May 15; 11(10):3958-65. Mitsiades CS, Poulaki V, McMullan C, Negri J, Fanourakis G, Goudopoulou A, Richon VM, Marks PA, Mitsiades N. PMID: 15897598.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    80. Thyroid carcinoma cells and Fas-mediated apoptosis. Thyroid. 2005 Feb; 15(2):178-9. Mitsiades CS, Mitsiades N. PMID: 15812903.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    81. Proteasome inhibitors as therapeutics. Essays Biochem. 2005; 41:205-18. Mitsiades CS, Mitsiades N, Hideshima T, Richardson PG, Anderson KC. PMID: 16250907.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    82. Human retinoblastoma cells are resistant to apoptosis induced by death receptors: role of caspase-8 gene silencing. Invest Ophthalmol Vis Sci. 2005 Jan; 46(1):358-66. Poulaki V, Mitsiades CS, McMullan C, Fanourakis G, Negri J, Goudopoulou A, Halikias IX, Voutsinas G, Tseleni-Balafouta S, Miller JW, Mitsiades N. PMID: 15623796.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    83. Focus on multiple myeloma. Cancer Cell. 2004 Nov; 6(5):439-44. Mitsiades CS, Mitsiades N, Munshi NC, Anderson KC. PMID: 15542427.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    84. Insulin-like growth factor-I plays a pathogenetic role in diabetic retinopathy. Am J Pathol. 2004 Aug; 165(2):457-69. Poulaki V, Joussen AM, Mitsiades N, Mitsiades CS, Iliaki EF, Adamis AP. PMID: 15277220; PMCID: PMC1618554.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    85. CC-5013 (Celgene). Curr Opin Investig Drugs. 2004 Jun; 5(6):635-47. Mitsiades CS, Mitsiades N. PMID: 15242253.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    86. The Akt pathway: molecular targets for anti-cancer drug development. Curr Cancer Drug Targets. 2004 May; 4(3):235-56. Mitsiades CS, Mitsiades N, Koutsilieris M. PMID: 15134532.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    87. Activin a in the regulation of corneal neovascularization and vascular endothelial growth factor expression. Am J Pathol. 2004 Apr; 164(4):1293-302. Poulaki V, Mitsiades N, Kruse FE, Radetzky S, Iliaki E, Kirchhof B, Joussen AM. PMID: 15039217; PMCID: PMC1615358.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    88. 2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27. Apoptosis. 2004 Mar; 9(2):149-55. Chauhan D, Li G, Auclair D, Hideshima T, Podar K, Mitsiades N, Mitsiades C, Chen LB, Munshi N, Saxena S, Anderson KC. PMID: 15004512.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    89. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell. 2004 Mar; 5(3):221-30. Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Akiyama M, Hideshima T, Chauhan D, Joseph M, Libermann TA, García-Echeverría C, Pearson MA, Hofmann F, Anderson KC, Kung AL. PMID: 15050914.
      View in: PubMed   Mentions: 170     Fields:    Translation:Humans
    90. Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):540-5. Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Hideshima T, Akiyama M, Chauhan D, Munshi N, Gu X, Bailey C, Joseph M, Libermann TA, Richon VM, Marks PA, Anderson KC. PMID: 14695887; PMCID: PMC327183.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansCells
    91. Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma. Cancer Res. 2003 Dec 01; 63(23):8428-36. Hideshima T, Chauhan D, Hayashi T, Podar K, Akiyama M, Mitsiades C, MItsiades N, Gong B, Bonham L, de Vries P, Munshi N, Richardson PG, Singer JW, Anderson KC. PMID: 14679006.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    92. Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma. Oncogene. 2003 Nov 20; 22(52):8386-93. Hideshima T, Chauhan D, Hayashi T, Akiyama M, Mitsiades N, Mitsiades C, Podar K, Munshi NC, Richardson PG, Anderson KC. PMID: 14627979.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    93. Regulation of vascular endothelial growth factor expression by insulin-like growth factor I in thyroid carcinomas. J Clin Endocrinol Metab. 2003 Nov; 88(11):5392-8. Poulaki V, Mitsiades CS, McMullan C, Sykoutri D, Fanourakis G, Kotoula V, Tseleni-Balafouta S, Koutras DA, Mitsiades N. PMID: 14602779.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    94. Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications. Cancer Res. 2003 Oct 15; 63(20):6689-96. Mitsiades CS, Mitsiades NS, Bronson RT, Chauhan D, Munshi N, Treon SP, Maxwell CA, Pilarski L, Hideshima T, Hoffman RM, Anderson KC. PMID: 14583463.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    95. Effect of imatinib mesylate (Gleevec) on anaplastic thyroid carcinoma cell lines. J Clin Endocrinol Metab. 2003 Oct; 88(10):5043-4; author reply 5044. Mitsiades CS, Sykoutri D, McMullan C, Poulaki V, Mitsiades N. PMID: 14557495.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    96. Immunomodulatory drug costimulates T cells via the B7-CD28 pathway. Blood. 2004 Mar 01; 103(5):1787-90. LeBlanc R, Hideshima T, Catley LP, Shringarpure R, Burger R, Mitsiades N, Mitsiades C, Cheema P, Chauhan D, Richardson PG, Anderson KC, Munshi NC. PMID: 14512311.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCells
    97. Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells. Oncogene. 2003 Sep 18; 22(40):6296-300. Chauhan D, Li G, Sattler M, Podar K, Mitsiades C, Mitsiades N, Munshi N, Hideshima T, Anderson KC. PMID: 13679868.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    98. Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling. Cancer Res. 2003 09 15; 63(18):5850-8. Tai YT, Podar K, Catley L, Tseng YH, Akiyama M, Shringarpure R, Burger R, Hideshima T, Chauhan D, Mitsiades N, Richardson P, Munshi NC, Kahn CR, Mitsiades C, Anderson KC. PMID: 14522909.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    99. Identification of genes modulated in multiple myeloma using genetically identical twin samples. Blood. 2004 Mar 01; 103(5):1799-806. Munshi NC, Hideshima T, Carrasco D, Shammas M, Auclair D, Davies F, Mitsiades N, Mitsiades C, Kim RS, Li C, Rajkumar SV, Fonseca R, Bergsagel L, Chauhan D, Anderson KC. PMID: 12969976.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    100. Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis. Blood. 2003 Dec 15; 102(13):4504-11. Davies FE, Dring AM, Li C, Rawstron AC, Shammas MA, O'Connor SM, Fenton JA, Hideshima T, Chauhan D, Tai IT, Robinson E, Auclair D, Rees K, Gonzalez D, Ashcroft AJ, Dasgupta R, Mitsiades C, Mitsiades N, Chen LB, Wong WH, Munshi NC, Morgan GJ, Anderson KC. PMID: 12947006.
      View in: PubMed   Mentions: 82     Fields:    Translation:Humans
    101. The role of apoptosis-inducing receptors of the tumor necrosis factor family in thyroid cancer. J Endocrinol. 2003 Aug; 178(2):205-16. Mitsiades CS, Poulaki V, Mitsiades N. PMID: 12904168.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    102. Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance. Blood. 2003 Nov 01; 102(9):3379-86. Chauhan D, Li G, Hideshima T, Podar K, Mitsiades C, Mitsiades N, Catley L, Tai YT, Hayashi T, Shringarpure R, Burger R, Munshi N, Ohtake Y, Saxena S, Anderson KC. PMID: 12855565.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    103. NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood. 2003 Oct 01; 102(7):2615-22. Catley L, Weisberg E, Tai YT, Atadja P, Remiszewski S, Hideshima T, Mitsiades N, Shringarpure R, LeBlanc R, Chauhan D, Munshi NC, Schlossman R, Richardson P, Griffin J, Anderson KC. PMID: 12816865.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    104. P2X7 polymorphism and chronic lymphocytic leukaemia. Lancet. 2003 Apr 26; 361(9367):1478; author reply 1478-9. Mitsiades CS, Mitsiades N. PMID: 12727428.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    105. Proteomic analyses in Waldenstrom's macroglobulinemia and other plasma cell dyscrasias. Semin Oncol. 2003 Apr; 30(2):156-60. Mitsiades CS, Mitsiades N, Treon SP, Anderson KC. PMID: 12720127.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    106. Expression of serotherapy target antigens in Waldenstrom's macroglobulinemia: therapeutic applications and considerations. Semin Oncol. 2003 Apr; 30(2):248-52. Treon SP, Kelliher A, Keele B, Frankel S, Emmanouilides C, Kimby E, Schlossman R, Mitsiades N, Mitsiades C, Preffer F, Anderson KC. PMID: 12720146.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    107. Novel biologically based therapies for Waldenstrom's macroglobulinemia. Semin Oncol. 2003 Apr; 30(2):309-12. Mitsiades CS, Mitsiades N, Richardson PG, Treon SP, Anderson KC. PMID: 12720159.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    108. JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells. J Biol Chem. 2003 May 16; 278(20):17593-6. Chauhan D, Li G, Hideshima T, Podar K, Mitsiades C, Mitsiades N, Munshi N, Kharbanda S, Anderson KC. PMID: 12665525.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    109. Molecular sequelae of histone deacetylase inhibition in human malignant B cells. Blood. 2003 May 15; 101(10):4055-62. Mitsiades N, Mitsiades CS, Richardson PG, McMullan C, Poulaki V, Fanourakis G, Schlossman R, Chauhan D, Munshi NC, Hideshima T, Richon VM, Marks PA, Anderson KC. PMID: 12531799.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    110. VEGF-dependent conjunctivalization of the corneal surface. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):117-23. Joussen AM, Poulaki V, Mitsiades N, Stechschulte SU, Kirchhof B, Dartt DA, Fong GH, Rudge J, Wiegand SJ, Yancopoulos GD, Adamis AP. PMID: 12506063.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    111. Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res. 2003 Jan 01; 63(1):18-21. Akiyama M, Hideshima T, Hayashi T, Tai YT, Mitsiades CS, Mitsiades N, Chauhan D, Richardson P, Munshi NC, Anderson KC. PMID: 12517770.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    112. Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays. Blood. 2003 May 01; 101(9):3606-14. Chauhan D, Li G, Auclair D, Hideshima T, Richardson P, Podar K, Mitsiades N, Mitsiades C, Li C, Kim RS, Munshi N, Chen LB, Wong W, Anderson KC. PMID: 12480690.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    113. Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells. J Biol Chem. 2003 Feb 21; 278(8):5794-801. Podar K, Tai YT, Cole CE, Hideshima T, Sattler M, Hamblin A, Mitsiades N, Schlossman RL, Davies FE, Morgan GJ, Munshi NC, Chauhan D, Anderson KC. PMID: 12482878.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    114. Constitutive nuclear factor-kappaB activity is crucial for human retinoblastoma cell viability. Am J Pathol. 2002 12; 161(6):2229-40. Poulaki V, Mitsiades CS, Joussen AM, Lappas A, Kirchhof B, Mitsiades N. PMID: 12466137; PMCID: PMC1850903.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    115. Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes. FASEB J. 2003 Jan; 17(1):76-8. Joussen AM, Poulaki V, Mitsiades N, Cai WY, Suzuma I, Pak J, Ju ST, Rook SL, Esser P, Mitsiades CS, Kirchhof B, Adamis AP, Aiello LP. PMID: 12475915.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    116. CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling. Blood. 2003 Apr 01; 101(7):2762-9. Tai YT, Podar K, Mitsiades N, Lin B, Mitsiades C, Gupta D, Akiyama M, Catley L, Hideshima T, Munshi NC, Treon SP, Anderson KC. PMID: 12433678.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    117. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood. 2003 Mar 15; 101(6):2377-80. Mitsiades N, Mitsiades CS, Richardson PG, Poulaki V, Tai YT, Chauhan D, Fanourakis G, Gu X, Bailey C, Joseph M, Libermann TA, Schlossman R, Munshi NC, Hideshima T, Anderson KC. PMID: 12424198.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansCells
    118. Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14374-9. Mitsiades N, Mitsiades CS, Poulaki V, Chauhan D, Fanourakis G, Gu X, Bailey C, Joseph M, Libermann TA, Treon SP, Munshi NC, Richardson PG, Hideshima T, Anderson KC. PMID: 12391322; PMCID: PMC137891.
      View in: PubMed   Mentions: 225     Fields:    Translation:HumansCells
    119. Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood. 2003 Feb 15; 101(4):1530-4. Hideshima T, Mitsiades C, Akiyama M, Hayashi T, Chauhan D, Richardson P, Schlossman R, Podar K, Munshi NC, Mitsiades N, Anderson KC. PMID: 12393500.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansCells
    120. Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res. 2002 Sep 01; 62(17):4996-5000. LeBlanc R, Catley LP, Hideshima T, Lentzsch S, Mitsiades CS, Mitsiades N, Neuberg D, Goloubeva O, Pien CS, Adams J, Gupta D, Richardson PG, Munshi NC, Anderson KC. PMID: 12208752.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    121. Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene. 2002 Aug 22; 21(37):5673-83. Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, Anderson KC. PMID: 12173037.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansCells
    122. Regulation of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in thyroid carcinoma cells. Am J Pathol. 2002 Aug; 161(2):643-54. Poulaki V, Mitsiades CS, Kotoula V, Tseleni-Balafouta S, Ashkenazi A, Koutras DA, Mitsiades N. PMID: 12163389; PMCID: PMC1850734.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    123. Cytokines modulate telomerase activity in a human multiple myeloma cell line. Cancer Res. 2002 07 01; 62(13):3876-82. Akiyama M, Hideshima T, Hayashi T, Tai YT, Mitsiades CS, Mitsiades N, Chauhan D, Richardson P, Munshi NC, Anderson KC. PMID: 12097303.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    124. beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells. Exp Hematol. 2002 Jul; 30(7):711-20. Gupta D, Podar K, Tai YT, Lin B, Hideshima T, Akiyama M, LeBlanc R, Catley L, Mitsiades N, Mitsiades C, Chauhan D, Munshi NC, Anderson KC. PMID: 12135668.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    125. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood. 2002 Jun 15; 99(12):4525-30. Mitsiades N, Mitsiades CS, Poulaki V, Chauhan D, Richardson PG, Hideshima T, Munshi NC, Treon SP, Anderson KC. PMID: 12036884.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansCells
    126. Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications. Blood. 2002 Jun 01; 99(11):4079-86. Mitsiades N, Mitsiades CS, Poulaki V, Chauhan D, Richardson PG, Hideshima T, Munshi N, Treon SP, Anderson KC. PMID: 12010810.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    127. Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells. Blood. 2002 Mar 15; 99(6):2162-71. Mitsiades N, Mitsiades CS, Poulaki V, Anderson KC, Treon SP. PMID: 11877293.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    128. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem. 2002 May 10; 277(19):16639-47. Hideshima T, Chauhan D, Richardson P, Mitsiades C, Mitsiades N, Hayashi T, Munshi N, Dang L, Castro A, Palombella V, Adams J, Anderson KC. PMID: 11872748.
      View in: PubMed   Mentions: 305     Fields:    Translation:HumansCells
    129. Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am J Pathol. 2002 Feb; 160(2):501-9. Joussen AM, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP. PMID: 11839570; PMCID: PMC1850650.
      View in: PubMed   Mentions: 143     Fields:    Translation:AnimalsCells
    130. Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J. 2002 Mar; 16(3):438-40. Joussen AM, Poulaki V, Mitsiades N, Kirchhof B, Koizumi K, Döhmen S, Adamis AP. PMID: 11821258.
      View in: PubMed   Mentions: 211     Fields:    Translation:AnimalsCells
    131. CD20-directed serotherapy in patients with multiple myeloma: biologic considerations and therapeutic applications. J Immunother. 2002 Jan-Feb; 25(1):72-81. Treon SP, Pilarski LM, Belch AR, Kelliher A, Preffer FI, Shima Y, Mitsiades CS, Mitsiades NS, Szczepek AJ, Ellman L, Harmon D, Grossbard ML, Anderson KC. PMID: 11924912.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCellsCTClinical Trials
    132. Apoptosis induced by FasL and TRAIL/Apo2L in the pathogenesis of thyroid diseases. Trends Endocrinol Metab. 2001 Nov; 12(9):384-90. Mitsiades N, Poulaki V, Mitsiades CS, Koutras DA, Chrousos GP. PMID: 11595539.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    133. TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. Blood. 2001 Aug 01; 98(3):795-804. Mitsiades CS, Treon SP, Mitsiades N, Shima Y, Richardson P, Schlossman R, Hideshima T, Anderson KC. PMID: 11468181.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    134. Concepts in the use of TRAIL/Apo2L: an emerging biotherapy for myeloma and other neoplasias. Expert Opin Investig Drugs. 2001 Aug; 10(8):1521-30. Mitsiades N, Mitsiades CS, Poulaki V, Anderson KC, Treon SP. PMID: 11772267.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    135. The role of Fas and FasL as mediators of anticancer chemotherapy. Drug Resist Updat. 2001 Aug; 4(4):233-42. Poulaki V, Mitsiades CS, Mitsiades N. PMID: 11991678.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    136. Fas-mediated apoptosis in neuroblastoma requires mitochondrial activation and is inhibited by FLICE inhibitor protein and Bcl-2. Cancer Res. 2001 Jun 15; 61(12):4864-72. Poulaki V, Mitsiades N, Romero ME, Tsokos M. PMID: 11406564.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    137. Induction of tumour cell apoptosis by matrix metalloproteinase inhibitors: new tricks from a (not so) old drug. Expert Opin Investig Drugs. 2001 Jun; 10(6):1075-84. Mitsiades N, Poulaki V, Mitsiades CS, Anderson KC. PMID: 11772236.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    138. Fas/Fas ligand-associated apoptosis in experimental autoimmune uveoretinitis in rodents: role of proinflammatory corticotropin-releasing hormone. Exp Eye Res. 2001 Jun; 72(6):623-9. Poulaki V, Mitsiades N, Mastorakos G, Caspi RR, Chrousos GP, Bouzas E. PMID: 11384150.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    139. The Gem GTP-binding protein promotes morphological differentiation in neuroblastoma. Oncogene. 2001 May 31; 20(25):3217-25. Leone A, Mitsiades N, Ward Y, Spinelli B, Poulaki V, Tsokos M, Kelly K. PMID: 11423971.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    140. Tumor cell expression of CD59 is associated with resistance to CD20 serotherapy in patients with B-cell malignancies. J Immunother. 2001 May-Jun; 24(3):263-71. Treon SP, Mitsiades C, Mitsiades N, Young G, Doss D, Schlossman R, Anderson KC. PMID: 11394505.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    141. Tumor Cell Expression of CD59 Is Associated With Resistance to CD20 Serotherapy in Patients With B-Cell Malignancies. J Immunother (1991). 2001 May; 24(3):263-271. Treon SP, Mitsiades C, Mitsiades N, Young G, Doss D, Schlossman R, Anderson KC. PMID: 11395643.
      View in: PubMed   Mentions: 1     Fields:    
    142. Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5. Cancer Res. 2001 Mar 15; 61(6):2704-12. Mitsiades N, Poulaki V, Mitsiades C, Tsokos M. PMID: 11289151.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    143. Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity. Cancer Res. 2001 Jan 15; 61(2):577-81. Mitsiades N, Yu WH, Poulaki V, Tsokos M, Stamenkovic I. PMID: 11212252.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansCells
    144. Circulating thyroglobulin transcytosed by thyroid cells in complexed with secretory components of its endocytic receptor megalin. J Clin Endocrinol Metab. 2000 Sep; 85(9):3458-67. Marinò M, Chiovato L, Mitsiades N, Latrofa F, Andrews D, Tseleni-Balafouta S, Collins AB, Pinchera A, McCluskey RT. PMID: 10999849.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    145. Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res. 2000 Aug 01; 60(15):4122-9. Mitsiades N, Poulaki V, Tseleni-Balafouta S, Koutras DA, Stamenkovic I. PMID: 10945619.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    146. Fas ligand expression in thyroid follicular cells from patients with thionamide-treated Graves' disease. Thyroid. 2000 Jul; 10(7):527-32. Mitsiades N, Poulaki V, Tseleni-Balafouta S, Chrousos GP, Koutras DA. PMID: 10958304.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    147. Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation. Neuroimmunomodulation. 2000; 7(2):99-105. Orban Z, Mitsiades N, Burke TR, Tsokos M, Chrousos GP. PMID: 10686520.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    148. Fas-mediated apoptosis in Ewing's sarcoma cell lines by metalloproteinase inhibitors. J Natl Cancer Inst. 1999 Oct 06; 91(19):1678-84. Mitsiades N, Poulaki V, Leone A, Tsokos M. PMID: 10511596.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    149. Fas ligand expression in thyroid carcinomas: a potential mechanism of immune evasion. J Clin Endocrinol Metab. 1999 Aug; 84(8):2924-32. Mitsiades N, Poulaki V, Mastorakos G, Tseleni-Balafouta ST, Kotoula V, Koutras DA, Tsokos M. PMID: 10443700.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    150. Fas ligand is present in tumors of the Ewing's sarcoma family and is cleaved into a soluble form by a metalloproteinase. Am J Pathol. 1998 Dec; 153(6):1947-56. Mitsiades N, Poulaki V, Kotoula V, Leone A, Tsokos M. PMID: 9846984; PMCID: PMC1866328.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    151. The mercy of adrenocortical tumor cells on lymphocytes. Endocr Res. 1998 Aug-Nov; 24(3-4):711-6. Wolkersdörfer GW, Marx C, Lohmann T, Brauer S, Schröder S, Brown J, Mitsiades N, Chrousos GP, Bornstein SR. PMID: 9888563.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    152. Fas/Fas ligand up-regulation and Bcl-2 down-regulation may be significant in the pathogenesis of Hashimoto's thyroiditis. J Clin Endocrinol Metab. 1998 Jun; 83(6):2199-203. Mitsiades N, Poulaki V, Kotoula V, Mastorakos G, Tseleni-Balafouta S, Koutras DA, Tsokos M. PMID: 9626160.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    153. Chronic effects of a nonpeptide corticotropin-releasing hormone type I receptor antagonist on pituitary-adrenal function, body weight, and metabolic regulation. Endocrinology. 1998 Apr; 139(4):1546-55. Bornstein SR, Webster EL, Torpy DJ, Richman SJ, Mitsiades N, Igel M, Lewis DB, Rice KC, Joost HG, Tsokos M, Chrousos GP. PMID: 9528933.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    154. Hyperthyroidism in McCune-Albright syndrome with a review of thyroid abnormalities sixty years after the first report. Thyroid. 1997 Jun; 7(3):433-9. Mastorakos G, Mitsiades NS, Doufas AG, Koutras DA. PMID: 9226216.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
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