Ching-Hsien Chen

Title(s)Associate Professor, Nephrology
SchoolSchool of Medicine
vCardDownload vCard

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Defining and targeting mechanisms of smoke-mediated fibrosis progression
    NIH R01HL146802Apr 1, 2019 - Mar 31, 2024
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis. Redox Rep. 2023 Dec; 28(1):2152607. Dong XQ, Chu LK, Cao X, Xiong QW, Mao YM, Chen CH, Bi YL, Liu J, Yan XM. PMID: 36692085.
      View in: PubMed   Mentions: 5     Fields:    
    2. Spatial Decoding of Immune Cell Contribution to Fibroblastic Foci in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2023 09 15; 208(6):728-731. Yang DC, Hsu SW, Li JM, Oldham J, Chen CH. PMID: 37487177; PMCID: PMC10515576.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Inositol possesses antifibrotic activity and mitigates pulmonary fibrosis. Respir Res. 2023 May 16; 24(1):132. Li JM, Chang WH, Li L, Yang DC, Hsu SW, Kenyon NJ, Chen CH. PMID: 37194070; PMCID: PMC10189934.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Associations of Long-Term Physical Activity Trajectories With All-Cause Mortality in a General Population. Int J Public Health. 2023; 68:1605332. Lee CL, Liu WJ, Chen CH, Wang JS. PMID: 36726527; PMCID: PMC9884672.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. MTAP deficiency contributes to immune landscape remodelling and tumour evasion. Immunology. 2023 02; 168(2):331-345. Chang WH, Hsu SW, Zhang J, Li JM, Yang DD, Chu CW, Yoo EE, Zhang W, Yu SL, Chen CH. PMID: 36183155; PMCID: PMC9840685.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. The Role of MARCKS in Metastasis and Treatment Resistance of Solid Tumors. Cancers (Basel). 2022 Oct 08; 14(19). Chiu CL, Zhao H, Chen CH, Wu R, Brooks JD. PMID: 36230850; PMCID: PMC9563266.
      View in: PubMed   Mentions: 3  
    7. Reduced symmetric dimethylation stabilizes vimentin and promotes metastasis in MTAP-deficient lung cancer. EMBO Rep. 2022 08 03; 23(8):e54265. Chang WH, Chen YJ, Hsiao YJ, Chiang CC, Wang CY, Chang YL, Hong QS, Lin CY, Lin SU, Chang GC, Chen HY, Chen YJ, Chen CH, Yang PC, Yu SL. PMID: 35766227; PMCID: PMC9346486.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    8. A Novel Renoprotective Strategy: Upregulation of PD-L1 Mitigates Cisplatin-Induced Acute Kidney Injury. Int J Mol Sci. 2021 Dec 10; 22(24). Liu J, Yang DC, Zhang J, Hsu SW, Weiss RH, Chen CH. PMID: 34948109; PMCID: PMC8706395.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. Targeting the AXL Receptor in Combating Smoking-related Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2021 06; 64(6):734-746. Yang DC, Gu S, Li JM, Hsu SW, Chen SJ, Chang WH, Chen CH. PMID: 33730527; PMCID: PMC8456879.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    10. L-arginine as a potential GLP-1-mediated immunomodulator of Th17-related cytokines in people with obesity and asthma. Obes Sci Pract. 2021 Jun; 7(3):339-345. Liao SY, Linderholm A, Showalter MR, Chen CH, Fiehn O, Kenyon NJ. PMID: 34123401; PMCID: PMC8170586.
      View in: PubMed   Mentions: 4  
    11. MARCKS cooperates with NKAP to activate NF-kB signaling in smoke-related lung cancer. Theranostics. 2021; 11(9):4122-4136. Liu J, Chen SJ, Hsu SW, Zhang J, Li JM, Yang DC, Gu S, Pinkerton KE, Chen CH. PMID: 33754052; PMCID: PMC7977464.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    12. Therapeutic targeting of argininosuccinate synthase 1 (ASS1)-deficient pulmonary fibrosis. Mol Ther. 2021 04 07; 29(4):1487-1500. Li JM, Yang DC, Oldham J, Linderholm A, Zhang J, Liu J, Kenyon NJ, Chen CH. PMID: 33508432; PMCID: PMC8058484.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    13. Metabolic reprogramming: A driver of cigarette smoke-induced inflammatory lung diseases. Free Radic Biol Med. 2021 02 01; 163:392-401. Li L, Yang DC, Chen CH. PMID: 33387604; PMCID: PMC7870291.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    14. Potential New Therapeutic Approaches for Renal Cell Carcinoma. Semin Nephrol. 2020 01; 40(1):86-97. Yang DC, Chen CH. PMID: 32130970.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    15. Approximate Mortality Risks between Hyperuricemia and Diabetes in the United States. J Clin Med. 2019 Dec 03; 8(12). Chen PH, Chen YW, Liu WJ, Hsu SW, Chen CH, Lee CL. PMID: 31816820; PMCID: PMC6947281.
      View in: PubMed   Mentions: 6  
    16. Tackling MARCKS-PIP3 circuit attenuates fibroblast activation and fibrosis progression. FASEB J. 2019 12; 33(12):14354-14369. Yang DC, Li JM, Xu J, Oldham J, Phan SH, Last JA, Wu R, Chen CH. PMID: 31661644; PMCID: PMC6894092.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    17. Targeting the phosphorylation site of myristoylated alanine-rich C kinase substrate alleviates symptoms in a murine model of steroid-resistant asthma. Br J Pharmacol. 2019 04; 176(8):1122-1134. Wang CN, Lin YC, Chang BC, Chen CH, Wu R, Lee CC. PMID: 30706455; PMCID: PMC6451065.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    18. Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinoma. Signal Transduct Target Ther. 2019; 4:2. Xu J, Chang WH, Fong LWR, Weiss RH, Yu SL, Chen CH. PMID: 30701095; PMCID: PMC6345872.
      View in: PubMed   Mentions: 12     Fields:    
    19. Cigarette Smoking-Mediated Macrophage Reprogramming: Mechanistic Insights and Therapeutic Implications. J Nat Sci. 2018 Nov; 4(11). Yang DC, Chen CH. PMID: 30801020; PMCID: PMC6383770.
      View in: PubMed   Mentions: 15  
    20. An oxidation-resistant, recombinant alpha-1 antitrypsin produced in Nicotiana benthamiana. Free Radic Biol Med. 2018 05 20; 120:303-310. Silberstein DZ, Karuppanan K, Aung HH, Chen CH, Cross CE, McDonald KA. PMID: 29551638; PMCID: PMC6093210.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    21. Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers. Cancer Metastasis Rev. 2017 Dec; 36(4):737-747. Fong LWR, Yang DC, Chen CH. PMID: 29039083.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    22. Cigarette Smoke Regulates the Competitive Interactions between NRF2 and BACH1 for Heme Oxygenase-1 Induction. Int J Mol Sci. 2017 Nov 10; 18(11). Chang WH, Thai P, Xu J, Yang DC, Wu R, Chen CH. PMID: 29125538; PMCID: PMC5713355.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. GHetting to know ADPKD proliferative signaling, STAT. Kidney Int. 2017 03; 91(3):524-526. Chen CH, Weiss RH. PMID: 28202165.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. Upregulation of MARCKS in kidney cancer and its potential as a therapeutic target. Oncogene. 2017 06 22; 36(25):3588-3598. Chen CH, Fong LWR, Yu E, Wu R, Trott JF, Weiss RH. PMID: 28166200; PMCID: PMC5926797.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    25. Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. Oncotarget. 2016 10 11; 7(41):66540-66557. Trott JF, Kim J, Abu Aboud O, Wettersten H, Stewart B, Berryhill G, Uzal F, Hovey RC, Chen CH, Anderson K, Graef A, Sarver AL, Modiano JF, Weiss RH. PMID: 27572319; PMCID: PMC5341819.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    26. Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth. Mol Cancer Ther. 2016 09; 15(9):2119-29. Abu Aboud O, Chen CH, Senapedis W, Baloglu E, Argueta C, Weiss RH. PMID: 27390344; PMCID: PMC5010932.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    27. HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms. Oncogene. 2016 10 27; 35(43):5674-5685. Chen CH, Chang WH, Su KY, Ku WH, Chang GC, Hong QS, Hsiao YJ, Chen HC, Chen HY, Wu R, Yang PC, Chen JJ, Yu SL. PMID: 27065329.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    28. Elevated MARCKS phosphorylation contributes to unresponsiveness of breast cancer to paclitaxel treatment. Oncotarget. 2015 Jun 20; 6(17):15194-208. Chen CH, Cheng CT, Yuan Y, Zhai J, Arif M, Fong LW, Wu R, Ann DK. PMID: 26015406; PMCID: PMC4558145.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    29. IIIDB: a database for isoform-isoform interactions and isoform network modules. BMC Genomics. 2015; 16 Suppl 2:S10. Tseng YT, Li W, Chen CH, Zhang S, Chen JJ, Zhou X, Liu CC. PMID: 25707505; PMCID: PMC4331710.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    30. Targeting myristoylated alanine-rich C kinase substrate phosphorylation site domain in lung cancer. Mechanisms and therapeutic implications. Am J Respir Crit Care Med. 2014 Nov 15; 190(10):1127-38. Chen CH, Statt S, Chiu CL, Thai P, Arif M, Adler KB, Wu R. PMID: 25318062; PMCID: PMC4299640.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    31. Shisa3 is associated with prolonged survival through promoting β-catenin degradation in lung cancer. Am J Respir Crit Care Med. 2014 Aug 15; 190(4):433-44. Chen CC, Chen HY, Su KY, Hong QS, Yan BS, Chen CH, Pan SH, Chang YL, Wang CJ, Hung PF, Yuan S, Chang GC, Chen JJ, Yang PC, Yang YC, Yu SL. PMID: 25036006.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    32. A novel predictor of cancer malignancy: up-regulation of myristoylated alanine-rich C kinase substrate phosphorylation in lung cancer. Am J Respir Crit Care Med. 2014 Apr 15; 189(8):1002-4. Chen CH, Chiu CL, Adler KB, Wu R. PMID: 24735036; PMCID: PMC4098099.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    33. A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis. Oncogene. 2014 Jul 10; 33(28):3696-706. Chen CH, Thai P, Yoneda K, Adler KB, Yang PC, Wu R. PMID: 23955080; PMCID: PMC4631387.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    34. Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines. Am J Respir Cell Mol Biol. 2013 Aug; 49(2):204-11. Thai P, Statt S, Chen CH, Liang E, Campbell C, Wu R. PMID: 23672216; PMCID: PMC3824039.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCellsCTClinical Trials
    35. Deletion of ATG5 shows a role of autophagy in salivary homeostatic control. J Dent Res. 2013 Oct; 92(10):911-7. Morgan-Bathke M, Lin HH, Chibly AM, Zhang W, Sun X, Chen CH, Flodby P, Borok Z, Wu R, Arnett D, Klein RR, Ann DK, Limesand KH. PMID: 23884556; PMCID: PMC3775371.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    36. A novel function of YWHAZ/β-catenin axis in promoting epithelial-mesenchymal transition and lung cancer metastasis. Mol Cancer Res. 2012 Oct; 10(10):1319-31. Chen CH, Chuang SM, Yang MF, Liao JW, Yu SL, Chen JJ. PMID: 22912335.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    37. Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniae infections: comparative virulence analysis with hypermucoviscosity-negative strain. BMC Microbiol. 2011 Mar 08; 11:50. Lin YC, Lu MC, Tang HL, Liu HC, Chen CH, Liu KS, Lin C, Chiou CS, Chiang MK, Chen CM, Lai YC. PMID: 21385400; PMCID: PMC3060850.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    38. Acidic stress facilitates tyrosine phosphorylation of HLJ1 to associate with actin cytoskeleton in lung cancer cells. Exp Cell Res. 2010 Oct 15; 316(17):2910-21. Chen CH, Lin H, Chuang SM, Lin SY, Chen JJ. PMID: 20615403.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    39. Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol Cancer Ther. 2008 Nov; 7(11):3527-38. Lee CY, Sher HF, Chen HW, Liu CC, Chen CH, Lin CS, Yang PC, Tsay HS, Chen JJ. PMID: 19001436.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells