Ching-Hsien Chen

Title(s)	Associate Professor, Nephrology
School	School of Medicine
Email	jchchen@ucdavis.edu
vCard	Download vCard

Overview

Websites

	School of Medicine faculty profile
	Lab website

Research

Research Activities and Funding

Defining and targeting mechanisms of smoke-mediated fibrosis progression
NIH R01HL146802Apr 1, 2019 - Mar 31, 2024
Role: Principal Investigator

ORNG Applications

Featured Publications

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis. Redox Rep. 2023 Dec; 28(1):2152607. Dong XQ, Chu LK, Cao X, Xiong QW, Mao YM, Chen CH, Bi YL, Liu J, Yan XM. PMID: 36692085.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry Met Metabolism
Spatial Decoding of Immune Cell Contribution to Fibroblastic Foci in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2023 09 15; 208(6):728-731. Yang DC, Hsu SW, Li JM, Oldham J, Chen CH. PMID: 37487177; PMCID: PMC10515576.

View in: PubMed Mentions: Fields:
Cri Critical Care Pul Pulmonary Medicine
Translation:Humans Cells
Inositol possesses antifibrotic activity and mitigates pulmonary fibrosis. Respir Res. 2023 May 16; 24(1):132. Li JM, Chang WH, Li L, Yang DC, Hsu SW, Kenyon NJ, Chen CH. PMID: 37194070; PMCID: PMC10189934.

View in: PubMed Mentions: Fields:
Pul Pulmonary Medicine
Translation:Animals Cells
Associations of Long-Term Physical Activity Trajectories With All-Cause Mortality in a General Population. Int J Public Health. 2023; 68:1605332. Lee CL, Liu WJ, Chen CH, Wang JS. PMID: 36726527; PMCID: PMC9884672.

View in: PubMed Mentions: Fields:
Pub Public Health
Translation:Humans
MTAP deficiency contributes to immune landscape remodelling and tumour evasion. Immunology. 2023 02; 168(2):331-345. Chang WH, Hsu SW, Zhang J, Li JM, Yang DD, Chu CW, Yoo EE, Zhang W, Yu SL, Chen CH. PMID: 36183155; PMCID: PMC9840685.

View in: PubMed Mentions: 1 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
The Role of MARCKS in Metastasis and Treatment Resistance of Solid Tumors. Cancers (Basel). 2022 Oct 08; 14(19). Chiu CL, Zhao H, Chen CH, Wu R, Brooks JD. PMID: 36230850; PMCID: PMC9563266.

View in: PubMed Mentions: 3
Reduced symmetric dimethylation stabilizes vimentin and promotes metastasis in MTAP-deficient lung cancer. EMBO Rep. 2022 08 03; 23(8):e54265. Chang WH, Chen YJ, Hsiao YJ, Chiang CC, Wang CY, Chang YL, Hong QS, Lin CY, Lin SU, Chang GC, Chen HY, Chen YJ, Chen CH, Yang PC, Yu SL. PMID: 35766227; PMCID: PMC9346486.

View in: PubMed Mentions: 5 Fields:
Mol Molecular Biology
Translation:Humans
A Novel Renoprotective Strategy: Upregulation of PD-L1 Mitigates Cisplatin-Induced Acute Kidney Injury. Int J Mol Sci. 2021 Dec 10; 22(24). Liu J, Yang DC, Zhang J, Hsu SW, Weiss RH, Chen CH. PMID: 34948109; PMCID: PMC8706395.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Animals Cells
Targeting the AXL Receptor in Combating Smoking-related Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2021 06; 64(6):734-746. Yang DC, Gu S, Li JM, Hsu SW, Chen SJ, Chang WH, Chen CH. PMID: 33730527; PMCID: PMC8456879.

View in: PubMed Mentions: 6 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
L-arginine as a potential GLP-1-mediated immunomodulator of Th17-related cytokines in people with obesity and asthma. Obes Sci Pract. 2021 Jun; 7(3):339-345. Liao SY, Linderholm A, Showalter MR, Chen CH, Fiehn O, Kenyon NJ. PMID: 34123401; PMCID: PMC8170586.

View in: PubMed Mentions: 4
MARCKS cooperates with NKAP to activate NF-kB signaling in smoke-related lung cancer. Theranostics. 2021; 11(9):4122-4136. Liu J, Chen SJ, Hsu SW, Zhang J, Li JM, Yang DC, Gu S, Pinkerton KE, Chen CH. PMID: 33754052; PMCID: PMC7977464.

View in: PubMed Mentions: 12 Fields:
Dia Diagnostic Imaging Mol Molecular Biology Nan Nanotechnology The Therapeutics
Translation:Humans Animals Cells
Therapeutic targeting of argininosuccinate synthase 1 (ASS1)-deficient pulmonary fibrosis. Mol Ther. 2021 04 07; 29(4):1487-1500. Li JM, Yang DC, Oldham J, Linderholm A, Zhang J, Liu J, Kenyon NJ, Chen CH. PMID: 33508432; PMCID: PMC8058484.

View in: PubMed Mentions: 9 Fields:
Mol Molecular Biology The Therapeutics
Translation:Humans Animals Cells
Metabolic reprogramming: A driver of cigarette smoke-induced inflammatory lung diseases. Free Radic Biol Med. 2021 02 01; 163:392-401. Li L, Yang DC, Chen CH. PMID: 33387604; PMCID: PMC7870291.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry Med Medicine (General)
Translation:Humans Animals
Potential New Therapeutic Approaches for Renal Cell Carcinoma. Semin Nephrol. 2020 01; 40(1):86-97. Yang DC, Chen CH. PMID: 32130970.

View in: PubMed Mentions: 20 Fields:
Nep Nephrology
Translation:Humans
Approximate Mortality Risks between Hyperuricemia and Diabetes in the United States. J Clin Med. 2019 Dec 03; 8(12). Chen PH, Chen YW, Liu WJ, Hsu SW, Chen CH, Lee CL. PMID: 31816820; PMCID: PMC6947281.

View in: PubMed Mentions: 6
Tackling MARCKS-PIP3 circuit attenuates fibroblast activation and fibrosis progression. FASEB J. 2019 12; 33(12):14354-14369. Yang DC, Li JM, Xu J, Oldham J, Phan SH, Last JA, Wu R, Chen CH. PMID: 31661644; PMCID: PMC6894092.

View in: PubMed Mentions: 10 Fields:
Bio Biology Phy Physiology
Translation:Humans Animals Cells
Targeting the phosphorylation site of myristoylated alanine-rich C kinase substrate alleviates symptoms in a murine model of steroid-resistant asthma. Br J Pharmacol. 2019 04; 176(8):1122-1134. Wang CN, Lin YC, Chang BC, Chen CH, Wu R, Lee CC. PMID: 30706455; PMCID: PMC6451065.

View in: PubMed Mentions: 6 Fields:
Pha Pharmacology
Translation:Animals Cells
Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinoma. Signal Transduct Target Ther. 2019; 4:2. Xu J, Chang WH, Fong LWR, Weiss RH, Yu SL, Chen CH. PMID: 30701095; PMCID: PMC6345872.

View in: PubMed Mentions: 12 Fields:
Cel Cell Biology Dru Drug Therapy
Cigarette Smoking-Mediated Macrophage Reprogramming: Mechanistic Insights and Therapeutic Implications. J Nat Sci. 2018 Nov; 4(11). Yang DC, Chen CH. PMID: 30801020; PMCID: PMC6383770.

View in: PubMed Mentions: 15
An oxidation-resistant, recombinant alpha-1 antitrypsin produced in Nicotiana benthamiana. Free Radic Biol Med. 2018 05 20; 120:303-310. Silberstein DZ, Karuppanan K, Aung HH, Chen CH, Cross CE, McDonald KA. PMID: 29551638; PMCID: PMC6093210.

View in: PubMed Mentions: 7 Fields:
Bio Biochemistry Med Medicine (General)
Translation:Humans Cells
Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers. Cancer Metastasis Rev. 2017 Dec; 36(4):737-747. Fong LWR, Yang DC, Chen CH. PMID: 29039083.

View in: PubMed Mentions: 32 Fields:
Neo Neoplasms
Translation:Humans Animals
Cigarette Smoke Regulates the Competitive Interactions between NRF2 and BACH1 for Heme Oxygenase-1 Induction. Int J Mol Sci. 2017 Nov 10; 18(11). Chang WH, Thai P, Xu J, Yang DC, Wu R, Chen CH. PMID: 29125538; PMCID: PMC5713355.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Humans Cells
GHetting to know ADPKD proliferative signaling, STAT. Kidney Int. 2017 03; 91(3):524-526. Chen CH, Weiss RH. PMID: 28202165.

View in: PubMed Mentions: 1 Fields:
Nep Nephrology
Translation:Humans Cells
Upregulation of MARCKS in kidney cancer and its potential as a therapeutic target. Oncogene. 2017 06 22; 36(25):3588-3598. Chen CH, Fong LWR, Yu E, Wu R, Trott JF, Weiss RH. PMID: 28166200; PMCID: PMC5926797.

View in: PubMed Mentions: 20 Fields:
Mol Molecular Biology Neo Neoplasms
Translation:Humans Animals Cells
Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. Oncotarget. 2016 10 11; 7(41):66540-66557. Trott JF, Kim J, Abu Aboud O, Wettersten H, Stewart B, Berryhill G, Uzal F, Hovey RC, Chen CH, Anderson K, Graef A, Sarver AL, Modiano JF, Weiss RH. PMID: 27572319; PMCID: PMC5341819.

View in: PubMed Mentions: 30 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth. Mol Cancer Ther. 2016 09; 15(9):2119-29. Abu Aboud O, Chen CH, Senapedis W, Baloglu E, Argueta C, Weiss RH. PMID: 27390344; PMCID: PMC5010932.

View in: PubMed Mentions: 64 Fields:
Ant Antineoplastic Agents
Translation:Humans Animals Cells
HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms. Oncogene. 2016 10 27; 35(43):5674-5685. Chen CH, Chang WH, Su KY, Ku WH, Chang GC, Hong QS, Hsiao YJ, Chen HC, Chen HY, Wu R, Yang PC, Chen JJ, Yu SL. PMID: 27065329.

View in: PubMed Mentions: 17 Fields:
Mol Molecular Biology Neo Neoplasms
Translation:Humans Animals Cells
Elevated MARCKS phosphorylation contributes to unresponsiveness of breast cancer to paclitaxel treatment. Oncotarget. 2015 Jun 20; 6(17):15194-208. Chen CH, Cheng CT, Yuan Y, Zhai J, Arif M, Fong LW, Wu R, Ann DK. PMID: 26015406; PMCID: PMC4558145.

View in: PubMed Mentions: 27 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
IIIDB: a database for isoform-isoform interactions and isoform network modules. BMC Genomics. 2015; 16 Suppl 2:S10. Tseng YT, Li W, Chen CH, Zhang S, Chen JJ, Zhou X, Liu CC. PMID: 25707505; PMCID: PMC4331710.

View in: PubMed Mentions: 15 Fields:
Gen Genetics
Translation:Humans Cells
Targeting myristoylated alanine-rich C kinase substrate phosphorylation site domain in lung cancer. Mechanisms and therapeutic implications. Am J Respir Crit Care Med. 2014 Nov 15; 190(10):1127-38. Chen CH, Statt S, Chiu CL, Thai P, Arif M, Adler KB, Wu R. PMID: 25318062; PMCID: PMC4299640.

View in: PubMed Mentions: 40 Fields:
Cri Critical Care Pul Pulmonary Medicine
Translation:Humans Animals Cells
Shisa3 is associated with prolonged survival through promoting β-catenin degradation in lung cancer. Am J Respir Crit Care Med. 2014 Aug 15; 190(4):433-44. Chen CC, Chen HY, Su KY, Hong QS, Yan BS, Chen CH, Pan SH, Chang YL, Wang CJ, Hung PF, Yuan S, Chang GC, Chen JJ, Yang PC, Yang YC, Yu SL. PMID: 25036006.

View in: PubMed Mentions: 24 Fields:
Cri Critical Care Pul Pulmonary Medicine
Translation:Humans Animals Cells
A novel predictor of cancer malignancy: up-regulation of myristoylated alanine-rich C kinase substrate phosphorylation in lung cancer. Am J Respir Crit Care Med. 2014 Apr 15; 189(8):1002-4. Chen CH, Chiu CL, Adler KB, Wu R. PMID: 24735036; PMCID: PMC4098099.

View in: PubMed Mentions: 11 Fields:
Cri Critical Care Pul Pulmonary Medicine
Translation:Humans Cells
A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis. Oncogene. 2014 Jul 10; 33(28):3696-706. Chen CH, Thai P, Yoneda K, Adler KB, Yang PC, Wu R. PMID: 23955080; PMCID: PMC4631387.

View in: PubMed Mentions: 41 Fields:
Mol Molecular Biology Neo Neoplasms
Translation:Humans Animals Cells
Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines. Am J Respir Cell Mol Biol. 2013 Aug; 49(2):204-11. Thai P, Statt S, Chen CH, Liang E, Campbell C, Wu R. PMID: 23672216; PMCID: PMC3824039.

View in: PubMed Mentions: 124 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells CTClinical Trials
Deletion of ATG5 shows a role of autophagy in salivary homeostatic control. J Dent Res. 2013 Oct; 92(10):911-7. Morgan-Bathke M, Lin HH, Chibly AM, Zhang W, Sun X, Chen CH, Flodby P, Borok Z, Wu R, Arnett D, Klein RR, Ann DK, Limesand KH. PMID: 23884556; PMCID: PMC3775371.

View in: PubMed Mentions: 21 Fields:
Den Dentistry
Translation:Animals Cells
A novel function of YWHAZ/β-catenin axis in promoting epithelial-mesenchymal transition and lung cancer metastasis. Mol Cancer Res. 2012 Oct; 10(10):1319-31. Chen CH, Chuang SM, Yang MF, Liao JW, Yu SL, Chen JJ. PMID: 22912335.

View in: PubMed Mentions: 56 Fields:
Cel Cell Biology Mol Molecular Biology Neo Neoplasms
Translation:Humans Animals Cells
Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniae infections: comparative virulence analysis with hypermucoviscosity-negative strain. BMC Microbiol. 2011 Mar 08; 11:50. Lin YC, Lu MC, Tang HL, Liu HC, Chen CH, Liu KS, Lin C, Chiou CS, Chiang MK, Chen CM, Lai YC. PMID: 21385400; PMCID: PMC3060850.

View in: PubMed Mentions: 56 Fields:
Mic Microbiology
Translation:Humans Animals Cells
Acidic stress facilitates tyrosine phosphorylation of HLJ1 to associate with actin cytoskeleton in lung cancer cells. Exp Cell Res. 2010 Oct 15; 316(17):2910-21. Chen CH, Lin H, Chuang SM, Lin SY, Chen JJ. PMID: 20615403.

View in: PubMed Mentions: 3 Fields:
Cel Cell Biology
Translation:Humans Cells
Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol Cancer Ther. 2008 Nov; 7(11):3527-38. Lee CY, Sher HF, Chen HW, Liu CC, Chen CH, Lin CS, Yang PC, Tsay HS, Chen JJ. PMID: 19001436.

View in: PubMed Mentions: 46 Fields:
Ant Antineoplastic Agents
Translation:Humans Animals Cells