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Transcriptional-translational conflict: a novel exploitable tumor suppressive mechanism. Signal Transduct Target Ther. 2023 Sep 25; 8(1):361.
Mudryj M, Ghosh PM. PMID: 37743426; PMCID: PMC10518313.
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PubMed Mentions: Fields:
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Beyond Prostate Cancer: An Androgen Receptor Splice Variant Expression in Multiple Malignancies, Non-Cancer Pathologies, and Development. Biomedicines. 2023 Aug 07; 11(8).
Katleba KD, Ghosh PM, Mudryj M. PMID: 37626712; PMCID: PMC10452427.
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PubMed Mentions:
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Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies. Int J Mol Sci. 2023 Jul 13; 24(14).
Lucchesi CA, Vasilatis DM, Mantrala S, Chandrasekar T, Mudryj M, Ghosh PM. PMID: 37511154; PMCID: PMC10380322.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Androgen receptor transcriptional activity is required for heregulin-1β-mediated nuclear localization of the HER3/ErbB3 receptor tyrosine kinase. J Biol Chem. 2023 08; 299(8):104973.
Jathal MK, Siddiqui S, Vasilatis DM, Durbin Johnson BP, Drake C, Mooso BA, D'Abronzo LS, Batra N, Mudryj M, Ghosh PM. PMID: 37380074; PMCID: PMC10407237.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Cisplatin-induced increase in heregulin 1 and its attenuation by the monoclonal ErbB3 antibody seribantumab in bladder cancer. Sci Rep. 2023 06 14; 13(1):9617.
Steele TM, Tsamouri MM, Siddiqui S, Lucchesi CA, Vasilatis D, Mooso BA, Durbin-Johnson BP, Ma AH, Hejazi N, Parikh M, Mudryj M, Pan CX, Ghosh PM. PMID: 37316561; PMCID: PMC10267166.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Androgen receptor-dependent regulation of metabolism in high grade bladder cancer cells. Sci Rep. 2023 01 31; 13(1):1762.
Katleba KD, Tsamouri MM, Jathal M, Baek HB, Armenta RB, Tepper CG, Cortopassi G, Ghosh PM, Mudryj M. PMID: 36720985; PMCID: PMC9889754.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Comparative Cancer Cell Signaling in Muscle-Invasive Urothelial Carcinoma of the Bladder in Dogs and Humans. Biomedicines. 2021 Oct 14; 9(10).
Tsamouri MM, Steele TM, Mudryj M, Kent MS, Ghosh PM. PMID: 34680588; PMCID: PMC8533305.
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PubMed Mentions:
4
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Depletion of androgen receptor low molecular weight isoform reduces bladder tumor cell viability and induces apoptosis. Cancer Lett. 2021 04 28; 504:49-57.
Katleba K, Lombard AP, Tsamouri MM, Baek HB, Nishida KS, Libertini SJ, Platero AJ, Ma AH, Pan CX, Ghosh PM, Mudryj M. PMID: 33549708; PMCID: PMC7943249.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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The Androgen Receptor in Prostate Cancer: Effect of Structure, Ligands and Spliced Variants on Therapy. Biomedicines. 2020 Oct 15; 8(10).
Messner EA, Steele TM, Tsamouri MM, Hejazi N, Gao AC, Mudryj M, Ghosh PM. PMID: 33076388; PMCID: PMC7602609.
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PubMed Mentions:
27
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The p14ARF tumor suppressor restrains androgen receptor activity and prevents apoptosis in prostate cancer cells. Cancer Lett. 2020 07 28; 483:12-21.
Siddiqui S, Libertini SJ, Lucas CA, Lombard AP, Baek HB, Nakagawa RM, Nishida KS, Steele TM, Melgoza FU, Borowsky AD, Durbin-Johnson BP, Qi L, Ghosh PM, Mudryj M. PMID: 32330514; PMCID: PMC8034238.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Non-circadian aspects of BHLHE40 cellular function in cancer. Genes Cancer. 2020; 11(1-2):1-19.
Kiss Z, Mudryj M, Ghosh PM. PMID: 32577154; PMCID: PMC7289903.
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PubMed Mentions:
17
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XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies. Oncotarget. 2018 Oct 02; 9(77):34567-34581.
Baek HB, Lombard AP, Libertini SJ, Fernandez-Rubio A, Vinall R, Gandour-Edwards R, Nakagawa R, Vidallo K, Nishida K, Siddiqui S, Wettersten H, Landesman Y, Weiss RH, Ghosh PM, Mudryj M. PMID: 30349650; PMCID: PMC6195388.
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PubMed Mentions:
13 Fields:
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The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer. Oncogene. 2017 11 16; 36(46):6359-6373.
D'Abronzo LS, Bose S, Crapuchettes ME, Beggs RE, Vinall RL, Tepper CG, Siddiqui S, Mudryj M, Melgoza FU, Durbin-Johnson BP, deVere White RW, Ghosh PM. PMID: 28745319; PMCID: PMC5690844.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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The emerging role of the androgen receptor in bladder cancer. Endocr Relat Cancer. 2015 Oct; 22(5):R265-77.
Lombard AP, Mudryj M. PMID: 26229034.
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PubMed Mentions:
36 Fields:
Translation:
HumansCells
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Dicer ablation promotes a mesenchymal and invasive phenotype in bladder cancer cells. Oncol Rep. 2015 Sep; 34(3):1526-32.
Lombard AP, Lim RM, Nakagawa RM, Vidallo KD, Libertini SJ, Platero AJ, Mudryj M. PMID: 26166215.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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miR-148a dependent apoptosis of bladder cancer cells is mediated in part by the epigenetic modifier DNMT1. Mol Carcinog. 2016 May; 55(5):757-67.
Lombard AP, Mooso BA, Libertini SJ, Lim RM, Nakagawa RM, Vidallo KD, Costanzo NC, Ghosh PM, Mudryj M. PMID: 25865490; PMCID: PMC4600638.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Transcription of Nrdp1 by the androgen receptor is regulated by nuclear filamin A in prostate cancer. Endocr Relat Cancer. 2015 Jun; 22(3):369-86.
Savoy RM, Chen L, Siddiqui S, Melgoza FU, Durbin-Johnson B, Drake C, Jathal MK, Bose S, Steele TM, Mooso BA, D'Abronzo LS, Fry WH, Carraway KL, Mudryj M, Ghosh PM. PMID: 25759396; PMCID: PMC4433410.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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The role of EGFR family inhibitors in muscle invasive bladder cancer: a review of clinical data and molecular evidence. J Urol. 2015 Jan; 193(1):19-29.
Mooso BA, Vinall RL, Mudryj M, Yap SA, deVere White RW, Ghosh PM. PMID: 25158272; PMCID: PMC4405894.
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PubMed Mentions:
40 Fields:
Translation:
HumansCells
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On the origins of the androgen receptor low molecular weight species. Horm Cancer. 2013 Oct; 4(5):259-69.
Mudryj M, Tepper CG. PMID: 23860689; PMCID: PMC4353596.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization. Endocr Relat Cancer. 2012 Dec; 19(6):759-77.
Mooso BA, Vinall RL, Tepper CG, Savoy RM, Cheung JP, Singh S, Siddiqui S, Wang Y, Bedolla RG, Martinez A, Mudryj M, Kung HJ, Devere White RW, Ghosh PM. PMID: 22993077; PMCID: PMC3540117.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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The interleukin 6 receptor is a direct transcriptional target of E2F3 in prostate tumor derived cells. Prostate. 2012 May 01; 72(6):649-60.
Libertini SJ, Chen H, al-Bataina B, Koilvaram T, George M, Gao AC, Mudryj M. PMID: 21837779.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Targeting ErbB3: the New RTK(id) on the Prostate Cancer Block. Immunol Endocr Metab Agents Med Chem. 2011 Jun; 11(2):131-149.
Jathal MK, Chen L, Mudryj M, Ghosh PM. PMID: 21603064; PMCID: PMC3095967.
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PubMed Mentions:
39
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Genome-wide analysis of androgen receptor binding and gene regulation in two CWR22-derived prostate cancer cell lines. Endocr Relat Cancer. 2010 Dec; 17(4):857-73.
Chen H, Libertini SJ, George M, Dandekar S, Tepper CG, Al-Bataina B, Kung HJ, Ghosh PM, Mudryj M. PMID: 20634343; PMCID: PMC3539310.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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ERK regulates calpain 2-induced androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines. J Biol Chem. 2010 Jan 22; 285(4):2368-74.
Chen H, Libertini SJ, Wang Y, Kung HJ, Ghosh P, Mudryj M. PMID: 19946123; PMCID: PMC2807295.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Nuclear versus cytoplasmic localization of filamin A in prostate cancer: immunohistochemical correlation with metastases. Clin Cancer Res. 2009 Feb 01; 15(3):788-96.
Bedolla RG, Wang Y, Asuncion A, Chamie K, Siddiqui S, Mudryj MM, Prihoda TJ, Siddiqui J, Chinnaiyan AM, Mehra R, de Vere White RW, Ghosh PM. PMID: 19188148; PMCID: PMC2666194.
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PubMed Mentions:
64 Fields:
Translation:
HumansCells
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Progression of prostate cancer: multiple pathways to androgen independence. Cancer Lett. 2009 Feb 18; 274(2):177-86.
Devlin HL, Mudryj M. PMID: 18657355.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Impairment of the DNA repair and growth arrest pathways by p53R2 silencing enhances DNA damage-induced apoptosis in a p53-dependent manner in prostate cancer cells. Mol Cancer Res. 2008 May; 6(5):808-18.
Devlin HL, Mack PC, Burich RA, Gumerlock PH, Kung HJ, Mudryj M, deVere White RW. PMID: 18505925.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independence. Cancer Res. 2007 Oct 01; 67(19):9001-5.
Libertini SJ, Tepper CG, Rodriguez V, Asmuth DM, Kung HJ, Mudryj M. PMID: 17909000.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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E2F1 expression in LNCaP prostate cancer cells deregulates androgen dependent growth, suppresses differentiation, and enhances apoptosis. Prostate. 2006 Jan 01; 66(1):70-81.
Libertini SJ, Tepper CG, Guadalupe M, Lu Y, Asmuth DM, Mudryj M. PMID: 16114066.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype. Cancer Res. 2005 Dec 01; 65(23):10700-8.
Libertini SJ, Robinson BS, Dhillon NK, Glick D, George M, Dandekar S, Gregg JP, Sawai E, Mudryj M. PMID: 16322214.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Hepatitis C virus core protein expression leads to biphasic regulation of the p21 cdk inhibitor and modulation of hepatocyte cell cycle. Virology. 2003 Jul 20; 312(1):245-53.
Nguyen H, Mudryj M, Guadalupe M, Dandekar S. PMID: 12890637.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Cyclin E overexpression enhances cytokine-mediated apoptosis in MCF7 breast cancer cells. Genes Immun. 2003 Jul; 4(5):336-42.
Dhillon NK, Mudryj M. PMID: 12847548.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Ectopic expression of cyclin E in estrogen responsive cells abrogates antiestrogen mediated growth arrest. Oncogene. 2002 Jul 11; 21(30):4626-34.
Dhillon NK, Mudryj M. PMID: 12096339.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle. J Virol. 2002 Apr; 76(8):3587-95.
Ndolo T, Dhillon NK, Nguyen H, Guadalupe M, Mudryj M, Dandekar S. PMID: 11907198; PMCID: PMC136077.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription. EMBO J. 2001 Oct 15; 20(20):5737-47.
Fojas de Borja P, Collins NK, Du P, Azizkhan-Clifford J, Mudryj M. PMID: 11598016; PMCID: PMC125670.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Fas-mediated apoptosis of proliferating, transiently growth-arrested, and senescent normal human fibroblasts. Exp Cell Res. 2000 Oct 10; 260(1):9-19.
Tepper CG, Seldin MF, Mudryj M. PMID: 11010806.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Deregulation of specific E2F complexes by the v-mos oncogene. Oncogene. 1997 Jun 26; 14(25):3029-38.
Afshari CA, Rhodes N, Paules RS, Mudryj M. PMID: 9223666.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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A role for a p21-E2F interaction during senescence arrest of normal human fibroblasts. Cell Growth Differ. 1996 Aug; 7(8):979-88.
Afshari CA, Nichols MA, Xiong Y, Mudryj M. PMID: 8853893.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection. Mol Cell Biol. 1992 Oct; 12(10):4364-74.
Wade M, Kowalik TF, Mudryj M, Huang ES, Azizkhan JC. PMID: 1328853; PMCID: PMC360360.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. Cell. 1992 Jan 10; 68(1):167-76.
Devoto SH, Mudryj M, Pines J, Hunter T, Nevins JR. PMID: 1310073.
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PubMed Mentions:
119 Fields:
Translation:
HumansAnimalsCells
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Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell. 1991 Jun 28; 65(7):1243-53.
Mudryj M, Devoto SH, Hiebert SW, Hunter T, Pines J, Nevins JR. PMID: 1829647.
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PubMed Mentions:
128 Fields:
Translation:
AnimalsCells
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The E2F transcription factor is a cellular target for the RB protein. Cell. 1991 Jun 14; 65(6):1053-61.
Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR. PMID: 1828392.
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PubMed Mentions:
469 Fields:
Translation:
HumansCells
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E2F transcription factor is a target for the RB protein and the cyclin A protein. Cold Spring Harb Symp Quant Biol. 1991; 56:157-62.
Nevins JR, Chellappan SP, Mudryj M, Hiebert S, Devoto S, Horowitz J, Hunter T, Pines J. PMID: 1840249.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J. 1990 Jul; 9(7):2179-84.
Mudryj M, Hiebert SW, Nevins JR. PMID: 2141565; PMCID: PMC551940.
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PubMed Mentions:
91 Fields:
Translation:
AnimalsCells
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Deletion analysis of the mouse alpha 1(III) collagen promoter. Nucleic Acids Res. 1988 Aug 11; 16(15):7513-26.
Mudryj M, de Crombrugghe B. PMID: 3412893; PMCID: PMC338424.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin. Proc Natl Acad Sci U S A. 1986 10; 83(19):7137-41.
Wewer UM, Liotta LA, Jaye M, Ricca GA, Drohan WN, Claysmith AP, Rao CN, Wirth P, Coligan JE, Albrechtsen R, Mudryj M, Sobel M. PMID: 2429301; PMCID: PMC386670.
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PubMed Mentions:
69 Fields:
Translation:
HumansCells
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Transcriptional activation encoded by the v-fos gene. Proc Natl Acad Sci U S A. 1986 May; 83(10):3213-7.
Setoyama C, Frunzio R, Liau G, Mudryj M, de Crombrugghe B. PMID: 3010284; PMCID: PMC323483.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Identification of the promoter and first exon of the mouse alpha 1 (III) collagen gene. J Biol Chem. 1985 Mar 25; 260(6):3773-7.
Liau G, Mudryj M, de Crombrugghe B. PMID: 3972847.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Structural and functional analysis of the genes for alpha 2(I) and alpha 1(III) collagens. Ann N Y Acad Sci. 1985; 460:154-62.
de Crombrugghe B, Schmidt A, Liau G, Setoyama C, Mudryj M, Yamada Y, McKeon C. PMID: 3868943.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Structural and functional studies on the interstitial collagen genes. Ciba Found Symp. 1985; 114:20-33.
de Crombrugghe B, Liau G, Setoyama C, Schmidt A, McKeon C, Mudryj M. PMID: 2998711.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Conservation of the sizes for one but not another class of exons in two chick collagen genes. Nature. 1984 Jul 26-Aug 1; 310(5975):333-7.
Yamada Y, Liau G, Mudryj M, Obici S, de Crombrugghe B. PMID: 6547770.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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A uniquely conserved regulatory signal is found around the translation initiation site in three different collagen genes. J Biol Chem. 1983 Dec 25; 258(24):14914-9.
Yamada Y, Mudryj M, de Crombrugghe B. PMID: 6689169.
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PubMed Mentions:
29 Fields:
Translation:
Cells
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Isolation and characterization of a genomic clone encoding chick alpha 1 type III collagen. J Biol Chem. 1983 Mar 10; 258(5):2758-61.
Yamada Y, Mudryj M, Sullivan M, de Crombrugghe B. PMID: 6298201.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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A repetitive structure in the chick alpha 2-collagen gene. Cold Spring Harb Symp Quant Biol. 1981; 45 Pt 2:777-83.
Vogeli G, Ohkubo H, Avvedimento VE, Sullivan M, Yamada Y, Mudryj M, Pastan I, de Crombrugghe B. PMID: 6942950.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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The collagen gene: evidence for its evolutinary assembly by amplification of a DNA segment containing an exon of 54 bp. Cell. 1980 Dec; 22(3):887-92.
Yamada Y, Avvedimento VE, Mudryj M, Ohkubo H, Vogeli G, Irani M, Pastan I, de Crombrugghe B. PMID: 7460017.
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PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
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Isolation and characterization of overlapping genomic clones covering the chicken alpha 2 (type I) collagen gene. Proc Natl Acad Sci U S A. 1980 Dec; 77(12):7059-63.
Ohkubo H, Vogeli G, Mudryj M, Avvedimento VE, Sullivan M, Pastan I, de Crombrugghe B. PMID: 6452631; PMCID: PMC350440.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Specificity of the bacteriophage lambda N gene product (pN): nut sequences are necessary and sufficient for antitermination by pN. Cell. 1979 Dec; 18(4):1145-51.
de Crombrugghe B, Mudryj M, DiLauro R, Gottesman M. PMID: 160286.
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PubMed Mentions:
33 Fields:
Translation:
Cells
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Nitrous acid mutagenesis of duplex DNA as a three-component system. Mutat Res. 1979 Jul; 61(2):129-51.
Thomas HF, Hartman PE, Mudryj M, Brown DL. PMID: 314585.
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PubMed Mentions:
3 Fields:
Translation:
Cells