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Kit Lam

TitleDEPARTMENT CHAIR
InstitutionUniversity of California Davis
DepartmentBiochemistry and Molecular Medicine
Address2700 Stockton Blvd
CA 95817
Phone916-734-0910
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Arun AS, Tepper CG, Lam KS. Identification of integrin drug targets for 17 solid tumor types. Oncotarget. 2018 Jul 10; 9(53):30146-30162. PMID: 30046394.
      View in: PubMed
    2. Shih TC, Liu R, Wu CT, Li X, Xiao W, Deng X, Kiss Z, Wang T, Chen X, Carney RP, Kung HJ, Duan Y, Ghosh PM, Lam KS. Targeting Galectin-1 impairs castration-resistant prostate cancer progression and invasion. Clin Cancer Res. 2018 Apr 17. PMID: 29666302.
      View in: PubMed
    3. Liu R, Li X, Xiao W, Lam KS. Corrigendum to 'Tumor-targeting peptides from combinatorial libraries' [Adv Drug Deliv Rev.110-111 (2017) 13-37]. Adv Drug Deliv Rev. 2018 Mar 09. PMID: 29530341.
      View in: PubMed
    4. Lam KS. Reply to Letter to the Editor. Curr Opin Chem Biol. 2018 Feb; 42:187. PMID: 29452736.
      View in: PubMed
    5. Yamagami T, Pleasure DE, Lam KS, Zhou CJ. Transient activation of Wnt/ß-catenin signaling reporter in fibrotic scar formation after compression spinal cord injury in adult mice. Biochem Biophys Res Commun. 2018 02 19; 496(4):1302-1307. PMID: 29410176.
      View in: PubMed
    6. Long Q, Lin TY, Huang Y, Li X, Ma AH, Zhang H, Carney R, Airhart S, Lam KS, deVere White RW, Pan CX, Li Y. Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model. Nanomedicine. 2018 Apr; 14(3):789-799. PMID: 29317342.
      View in: PubMed
    7. Xiao W, Suby N, Xiao K, Lin TY, Al Awwad N, Lam KS, Li Y. Extremely long tumor retention, multi-responsive boronate crosslinked micelles with superior therapeutic efficacy for ovarian cancer. J Control Release. 2017 Oct 28; 264:169-179. PMID: 28847739.
      View in: PubMed
    8. Yang X, Xue X, Luo Y, Lin TY, Zhang H, Lac D, Xiao K, He Y, Jia B, Lam KS, Li Y. Sub-100nm, long tumor retention SN-38-loaded photonic micelles for tri-modal cancer therapy. J Control Release. 2017 09 10; 261:297-306. PMID: 28700898.
      View in: PubMed
    9. Liu R, Li X, Lam KS. Combinatorial chemistry in drug discovery. Curr Opin Chem Biol. 2017 Jun; 38:117-126. PMID: 28494316.
      View in: PubMed
    10. Bharadwaj G, Nhan V, Yang S, Li X, Narayanan A, Macarenco AC, Shi Y, Yang D, Vieira LS, Xiao W, Li Y, Lam KS. Cholic acid-based novel micellar nanoplatform for delivering FDA-approved taxanes. Nanomedicine (Lond). 2017 May; 12(10):1153-1164. PMID: 28447909.
      View in: PubMed
    11. Carney RP, Hazari S, Colquhoun M, Tran D, Hwang B, Mulligan MS, Bryers JD, Girda E, Leiserowitz GS, Smith ZJ, Lam KS. Multispectral Optical Tweezers for Biochemical Fingerprinting of CD9-Positive Exosome Subpopulations. Anal Chem. 2017 May 16; 89(10):5357-5363. PMID: 28345878.
      View in: PubMed
    12. Carney RP, Thillier Y, Kiss Z, Sahabi A, Heleno Campos JC, Knudson A, Liu R, Olivos D, Saunders M, Tian L, Lam KS. Combinatorial Library Screening with Liposomes for Discovery of Membrane Active Peptides. ACS Comb Sci. 2017 05 08; 19(5):299-307. PMID: 28378995.
      View in: PubMed
    13. Shih TC, Liu R, Fung G, Bhardwaj G, Ghosh PM, Lam KS. A Novel Galectin-1 Inhibitor Discovered through One-Bead Two-Compound Library Potentiates the Antitumor Effects of Paclitaxel in vivo. Mol Cancer Ther. 2017 Jul; 16(7):1212-1223. PMID: 28396365.
      View in: PubMed
    14. Bustos-Villalobos I, Bergstrom JW, Haigh NE, Luna JI, Mitra A, Marusina AI, Merleev AA, Wang EA, Sukhov A, Sultani H, Liu R, Bhardwaj G, Guo W, Kung HJ, Lam KS, Maverakis E. ITK inhibition for the targeted treatment of CTCL. J Dermatol Sci. 2017 Jul; 87(1):88-91. PMID: 28434812.
      View in: PubMed
    15. Carney RP, Hazari S, Rojalin T, Knudson A, Gao T, Tang Y, Liu R, Viitala T, Yliperttula M, Lam KS. Targeting Tumor-Associated Exosomes with Integrin-Binding Peptides. Adv Biosyst. 2017 May; 1(5). PMID: 29911169.
      View in: PubMed
    16. Pan A, Zhang H, Li Y, Lin TY, Wang F, Lee J, Cheng M, Dall'Era M, Li T, deVere White R, Pan CX, Lam KS. Disulfide-crosslinked nanomicelles confer cancer-specific drug delivery and improve efficacy of paclitaxel in bladder cancer. Nanotechnology. 2016 Oct 21; 27(42):425103. PMID: 27640312.
      View in: PubMed
    17. Lin TY, Li Y, Liu Q, Chen JL, Zhang H, Lac D, Zhang H, Ferrara KW, Wachsmann-Hogiu S, Li T, Airhart S, deVere White R, Lam KS, Pan CX. Novel theranostic nanoporphyrins for photodynamic diagnosis and trimodal therapy for bladder cancer. Biomaterials. 2016 10; 104:339-51. PMID: 27479049.
      View in: PubMed
    18. Lin TY, Guo W, Long Q, Ma A, Liu Q, Zhang H, Huang Y, Chandrasekaran S, Pan C, Lam KS, Li Y. HSP90 Inhibitor Encapsulated Photo-Theranostic Nanoparticles for Synergistic Combination Cancer Therapy. Theranostics. 2016; 6(9):1324-35. PMID: 27375782; PMCID: PMC4924502.
    19. Liu R, Li X, Xiao W, Lam KS. Tumor-targeting peptides from combinatorial libraries. Adv Drug Deliv Rev. 2017 Feb; 110-111:13-37. PMID: 27210583.
      View in: PubMed
    20. Wu CY, Wang DH, Wang X, Dixon SM, Meng L, Ahadi S, Enter DH, Chen CY, Kato J, Leon LJ, Ramirez LM, Maeda Y, Reis CF, Ribeiro B, Weems B, Kung HJ, Lam KS. Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening. ACS Comb Sci. 2016 06 13; 18(6):320-9. PMID: 27053324; PMCID: PMC4908505.
    21. Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. ROR-? drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat Med. 2016 05; 22(5):488-96. PMID: 27019329; PMCID: PMC5030109.
    22. Xiao W, Li T, Bononi FC, Lac D, Kekessie IA, Liu Y, Sanchez E, Mazloom A, Ma AH, Lin J, Tran J, Yang K, Lam KS, Liu R. Discovery and characterization of a high-affinity and high-specificity peptide ligand LXY30 for in vivo targeting of a3 integrin-expressing human tumors. EJNMMI Res. 2016 Dec; 6(1):18. PMID: 26922417; PMCID: PMC4769701.
    23. Wang Y, Xiao W, Zhang Y, Meza L, Tseng H, Takada Y, Ames JB, Lam KS. Optimization of RGD-Containing Cyclic Peptides against avß3 Integrin. Mol Cancer Ther. 2016 Feb; 15(2):232-40. PMID: 26719578; PMCID: PMC4747864 [Available on 02/01/17].
    24. Awasthi S, Izu LT, Mao Z, Jian Z, Landas T, Lerner A, Shimkunas R, Woldeyesus R, Bossuyt J, Wood B, Chen YJ, Matthews DL, Lieu DK, Chiamvimonvat N, Lam KS, Chen-Izu Y, Chan JW. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes. Circ Res. 2016 Jan 22; 118(2):e19-28. PMID: 26643875; PMCID: PMC4740258 [Available on 01/22/17].
    25. Xiao K, Li YP, Wang C, Ahmad S, Vu M, Kuma K, Cheng YQ, Lam KS. Disulfide cross-linked micelles of novel HDAC inhibitor thailandepsin A for the treatment of breast cancer. Biomaterials. 2015 Oct; 67:183-93. PMID: 26218744; PMCID: PMC4550558 [Available on 10/01/16].
    26. Wang WP, Ho PY, Chen QX, Addepalli B, Limbach PA, Li MM, Wu WJ, Jilek JL, Qiu JX, Zhang HJ, Li T, Wun T, White RD, Lam KS, Yu AM. Bioengineering Novel Chimeric microRNA-34a for Prodrug Cancer Therapy: High-Yield Expression and Purification, and Structural and Functional Characterization. J Pharmacol Exp Ther. 2015 Aug; 354(2):131-41. PMID: 26022002; PMCID: PMC4518075.
    27. Lee C, Carney RP, Hazari S, Smith ZJ, Knudson A, Robertson CS, Lam KS, Wachsmann-Hogiu S. 3D plasmonic nanobowl platform for the study of exosomes in solution. Nanoscale. 2015; 7(20):9290-7. PMID: 25939587.
      View in: PubMed
    28. Liu R, Shih TC, Deng X, Anwar L, Ahadi S, Kumaresan P, Lam KS. Design, synthesis, and application of OB2C combinatorial peptide and peptidomimetic libraries. Methods Mol Biol. 2015; 1248:3-22. PMID: 25616322; PMCID: PMC4625904.
    29. Fujita M, Zhu K, Fujita CK, Zhao M, Lam KS, Kurth MJ, Takada YK, Takada Y. Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins avß3, a4ß1, and a5ß1. J Biol Chem. 2015 Jan 02; 290(1):259-71. PMID: 25398877; PMCID: PMC4281730.
    30. Li Y, Lin TY, Luo Y, Liu Q, Xiao W, Guo W, Lac D, Zhang H, Feng C, Wachsmann-Hogiu S, Walton JH, Cherry SR, Rowland DJ, Kukis D, Pan C, Lam KS. A smart and versatile theranostic nanomedicine platform based on nanoporphyrin. Nat Commun. 2014 Aug 26; 5:4712. PMID: 25158161.
      View in: PubMed
    31. Zhang H, Li Y, Lin TY, Xiao K, Haddad AS, Henderson PT, Jonas BA, Chen M, Xiao W, Liu R, Lam KS, Pan CX. Nanomicelle formulation modifies the pharmacokinetic profiles and cardiac toxicity of daunorubicin. Nanomedicine (Lond). 2014; 9(12):1807-20. PMID: 24628688; PMCID: PMC4167557.
    32. Xiao K, Suby N, Li Y, Lam KS. Telodendrimer-based nanocarriers for the treatment of ovarian cancer. Ther Deliv. 2013 Oct; 4(10):1279-92. PMID: 24116912; PMCID: PMC3936575.
    33. Li Y, Xiao K, Zhu W, Deng W, Lam KS. Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers. Adv Drug Deliv Rev. 2014 Feb; 66:58-73. PMID: 24060922; PMCID: PMC3947689.
    34. Yao W, Guan M, Jia J, Dai W, Lay YA, Amugongo S, Liu R, Olivos D, Saunders M, Lam KS, Nolta J, Olvera D, Ritchie RO, Lane NE. Reversing bone loss by directing mesenchymal stem cells to bone. Stem Cells. 2013 Sep; 31(9):2003-14. PMID: 23818248; PMCID: PMC3795809.
    35. Guo W, Liu R, Bhardwaj G, Ma AH, Changou C, Yang JC, Li Y, Feng C, Luo Y, Mazloom A, Sanchez E, Wang Y, Huang W, Patterson R, Evans CP, Lam KS, Kung HJ. CTA095, a novel Etk and Src dual inhibitor, induces apoptosis in prostate cancer cells and overcomes resistance to Src inhibitors. PLoS One. 2013; 8(8):e70910. PMID: 23967135.
      View in: PubMed
    36. Xiao W, Bononi FC, Townsend J, Li Y, Liu R, Lam KS. Immobilized OBOC combinatorial bead array to facilitate multiplicative screening. Comb Chem High Throughput Screen. 2013 Jul; 16(6):441-448. PMID: 23488896; PMCID: PMC4560360.
    37. He W, Luo J, Bourguet F, Xing L, Yi SK, Gao T, Blanchette C, Henderson PT, Kuhn E, Malfatti M, Murphy WJ, Cheng RH, Lam KS, Coleman MA. Controlling the diameter, monodispersity, and solubility of ApoA1 nanolipoprotein particles using telodendrimer chemistry. Protein Sci. 2013 Aug; 22(8):1078-86. PMID: 23754445; PMCID: PMC3832044.
    38. Lin TY, Li YP, Zhang H, Luo J, Goodwin N, Gao T, White Rde V, Lam KS, Pan CX. Tumor-targeting multifunctional micelles for imaging and chemotherapy of advanced bladder cancer. Nanomedicine (Lond). 2013 Aug; 8(8):1239-51. PMID: 23199207; PMCID: PMC3664656.
    39. Li Y, Budamagunta MS, Luo J, Xiao W, Voss JC, Lam KS. Probing of the assembly structure and dynamics within nanoparticles during interaction with blood proteins. ACS Nano. 2012 Nov 27; 6(11):9485-95. PMID: 23106540; PMCID: PMC3922124.
    40. Duru N, Fan M, Candas D, Menaa C, Liu HC, Nantajit D, Wen Y, Xiao K, Eldridge A, Chromy BA, Li S, Spitz DR, Lam KS, Wicha MS, Li JJ. HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clin Cancer Res. 2012 Dec 15; 18(24):6634-47. PMID: 23091114; PMCID: PMC3593096.
    41. Guo W, Liu R, Ono Y, Ma AH, Martinez A, Sanchez E, Wang Y, Huang W, Mazloom A, Li J, Ning J, Maverakis E, Lam KS, Kung HJ. Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Mol Pharmacol. 2012 Nov; 82(5):938-47. PMID: 22899868; PMCID: PMC3477223.
    42. Lin TY, Zhang H, Luo J, Li Y, Gao T, Lara PN, de Vere White R, Lam KS, Pan CX. Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer. Int J Nanomedicine. 2012; 7:2793-804. PMID: 22745542; PMCID: PMC3383352.
    43. Kato J, Li Y, Xiao K, Lee JS, Luo J, Tuscano JM, O'Donnell RT, Lam KS. Disulfide cross-linked micelles for the targeted delivery of vincristine to B-cell lymphoma. Mol Pharm. 2012 Jun 04; 9(6):1727-35. PMID: 22530955; PMCID: PMC4560237.
    44. Xiao W, Luo J, Jain T, Riggs JW, Tseng HP, Henderson PT, Cherry SR, Rowland D, Lam KS. Biodistribution and pharmacokinetics of a telodendrimer micellar paclitaxel nanoformulation in a mouse xenograft model of ovarian cancer. Int J Nanomedicine. 2012; 7:1587-97. PMID: 22605931; PMCID: PMC3352867.
    45. Xiao K, Li Y, Lee JS, Gonik AM, Dong T, Fung G, Sanchez E, Xing L, Cheng HR, Luo J, Lam KS. "OA02" peptide facilitates the precise targeting of paclitaxel-loaded micellar nanoparticles to ovarian cancer in vivo. Cancer Res. 2012 Apr 15; 72(8):2100-10. PMID: 22396491; PMCID: PMC3343697.
    46. Guan M, Yao W, Liu R, Lam KS, Nolta J, Jia J, Panganiban B, Meng L, Zhou P, Shahnazari M, Ritchie RO, Lane NE. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nat Med. 2012 Feb 05; 18(3):456-62. PMID: 22306732; PMCID: PMC3755884.
    47. Li Y, Xiao W, Xiao K, Berti L, Luo J, Tseng HP, Fung G, Lam KS. Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to acidic pH values and cis-diols. Angew Chem Int Ed Engl. 2012 Mar 19; 51(12):2864-9. PMID: 22253091; PMCID: PMC3545653.
    48. Zhang H, Luo J, Li Y, Henderson PT, Wang Y, Wachsmann-Hogiu S, Zhao W, Lam KS, Pan CX. Characterization of high-affinity peptides and their feasibility for use in nanotherapeutics targeting leukemia stem cells. Nanomedicine. 2012 Oct; 8(7):1116-24. PMID: 22197725; PMCID: PMC4577023.
    49. Xiao K, Luo J, Li Y, Lee JS, Fung G, Lam KS. PEG-oligocholic acid telodendrimer micelles for the targeted delivery of doxorubicin to B-cell lymphoma. J Control Release. 2011 Oct 30; 155(2):272-81. PMID: 21787818; PMCID: PMC3196055.
    50. Li Y, Xiao K, Luo J, Xiao W, Lee JS, Gonik AM, Kato J, Dong TA, Lam KS. Well-defined, reversible disulfide cross-linked micelles for on-demand paclitaxel delivery. Biomaterials. 2011 Sep; 32(27):6633-45. PMID: 21658763; PMCID: PMC3137548.
    51. Yao N, Chen CY, Wu CY, Motonishi K, Kung HJ, Lam KS. Novel flavonoids with antiproliferative activities against breast cancer cells. J Med Chem. 2011 Jul 14; 54(13):4339-49. PMID: 21599001; PMCID: PMC3169196.
    52. Aina OH, Maeda Y, Harrison M, Zwingenberger AL, Walker NJ, Lam KS, Kent MS. Canine malignant melanoma alpha-3 integrin binding peptides. Vet Immunol Immunopathol. 2011 Sep 15; 143(1-2):11-9. PMID: 21722969; PMCID: PMC4169883.
    53. Xiao K, Li Y, Luo J, Lee JS, Xiao W, Gonik AM, Agarwal RG, Lam KS. The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles. Biomaterials. 2011 May; 32(13):3435-46. PMID: 21295849; PMCID: PMC3055170.
    54. Chang PC, Fitzgerald LD, Hsia DA, Izumiya Y, Wu CY, Hsieh WP, Lin SF, Campbell M, Lam KS, Luciw PA, Tepper CG, Kung HJ. Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor. J Virol. 2011 Apr; 85(7):3283-93. PMID: 21228229; PMCID: PMC3067885.
    55. Berti L, Woldeyesus T, Li Y, Lam KS. Maximization of loading and stability of ssDNA:iron oxide nanoparticle complexes formed through electrostatic interaction. Langmuir. 2010 Dec 07; 26(23):18293-9. PMID: 21047109; PMCID: PMC2994962.
    56. Zhang H, Aina OH, Lam KS, de Vere White R, Evans C, Henderson P, Lara PN, Wang X, Bassuk JA, Pan CX. Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach. Urol Oncol. 2012 Sep; 30(5):635-45. PMID: 20888272; PMCID: PMC4572726.
    57. Xiao W, Wang Y, Lau EY, Luo J, Yao N, Shi C, Meza L, Tseng H, Maeda Y, Kumaresan P, Liu R, Lightstone FC, Takada Y, Lam KS. The use of one-bead one-compound combinatorial library technology to discover high-affinity avß3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle. Mol Cancer Ther. 2010 Oct; 9(10):2714-23. PMID: 20858725; PMCID: PMC3571112.
    58. Townsend JB, Shaheen F, Liu R, Lam KS. Jeffamine derivatized TentaGel beads and poly(dimethylsiloxane) microbead cassettes for ultrahigh-throughput in situ releasable solution-phase cell-based screening of one-bead-one-compound combinatorial small molecule libraries. J Comb Chem. 2010 Sep 13; 12(5):700-12. PMID: 20593859; PMCID: PMC3045263.
    59. Yao N, Fung G, Malekan H, Ye L, Kurth MJ, Lam KS. Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation. Carbohydr Res. 2010 Oct 13; 345(15):2277-81. PMID: 20832778; PMCID: PMC3207739.
    60. Luo J, Xiao K, Li Y, Lee JS, Shi L, Tan YH, Xing L, Holland Cheng R, Liu GY, Lam KS. Well-defined, size-tunable, multifunctional micelles for efficient paclitaxel delivery for cancer treatment. Bioconjug Chem. 2010 Jul 21; 21(7):1216-24. PMID: 20536174; PMCID: PMC2912451.
    61. Townsend J, Do A, Lehman A, Dixon S, Sanii B, Lam KS. 3-nitro-tyrosine as an internal quencher of autofluorescence enhances the compatibility of fluorescence based screening of OBOC combinatorial libraries. Comb Chem High Throughput Screen. 2010 Jun; 13(5):422-9. PMID: 20236063.
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    62. Li Y, Xiao K, Luo J, Lee J, Pan S, Lam KS. A novel size-tunable nanocarrier system for targeted anticancer drug delivery. J Control Release. 2010 Jun 15; 144(3):314-23. PMID: 20211210; PMCID: PMC2878919.
    63. Yao N, Xiao W, Meza L, Tseng H, Chuck M, Lam KS. Structure-activity relationship studies of targeting ligands against breast cancer cells. J Med Chem. 2009 Nov 12; 52(21):6744-51. PMID: 19835381.
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    64. Xiao K, Luo J, Fowler WL, Li Y, Lee JS, Xing L, Cheng RH, Wang L, Lam KS. A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer. Biomaterials. 2009 Oct; 30(30):6006-16. PMID: 19660809; PMCID: PMC2735593.
    65. Saegusa J, Yamaji S, Ieguchi K, Wu CY, Lam KS, Liu FT, Takada YK, Takada Y. The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling. J Biol Chem. 2009 Sep 04; 284(36):24106-14. PMID: 19578119; PMCID: PMC2782004.
    66. Denardo SJ, Liu R, Albrecht H, Natarajan A, Sutcliffe JL, Anderson C, Peng L, Ferdani R, Cherry SR, Lam KS. 111In-LLP2A-DOTA Polyethylene Glycol-Targeting {alpha}4{beta}1 Integrin: Comparative Pharmacokinetics for Imaging and Therapy of Lymphoid Malignancies. J Nucl Med. 2009 Apr; 50(4):625-34. PMID: 19289419.
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    67. Yao N, Xiao W, Wang X, Marik J, Park SH, Takada Y, Lam KS. Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method. J Med Chem. 2009 Jan 08; 52(1):126-33. PMID: 19055415; PMCID: PMC2836207.
    68. Kim TH, Venugopal SK, Zhu M, Wang SS, Lau D, Lam KS, Clemens DL, Zern MA. A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells. Biochem Biophys Res Commun. 2009 Feb 20; 379(4):876-81. PMID: 19133235.
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    69. Kumaresan PR, Luo J, Lam KS. On-demand cleavable linkers for radioimmunotherapy. Methods Mol Biol. 2009; 539:191-211. PMID: 19377973.
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    70. Kappel JC, Fan YC, Lam KS. Application of the "libraries from libraries" concept to "one-bead one-compound" combinatorial chemistry. Adv Exp Med Biol. 2009; 611:21-2. PMID: 19400077.
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    71. Baek HG, Liu R, Lam KS. Development of hydrogel TentaGel shell-core beads for ultrahigh throughput solution-phase screening of encoded OBOC combinatorial small molecule libraries. J Comb Chem. 2009 Jan-Feb; 11(1):91-102. PMID: 19061339; PMCID: PMC2693237.
    72. Luo J, Onofiok E, Shi C, Liu R, Lam KS. A novel hydrogel functionalized with specific peptidomimetic ligands for 2-D and 3-D cell culture. Adv Exp Med Biol. 2009; 611:19-20. PMID: 19400076.
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    73. Hong HS, Maezawa I, Budamagunta M, Rana S, Shi A, Vassar R, Liu R, Lam KS, Cheng RH, Hua DH, Voss JC, Jin LW. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiol Aging. 2010 Oct; 31(10):1690-9. PMID: 19022536; PMCID: PMC2888733.
    74. Xiao W, Yao N, Peng L, Liu R, Lam KS. Near-infrared optical imaging in glioblastoma xenograft with ligand-targeting alpha 3 integrin. Eur J Nucl Med Mol Imaging. 2009 Jan; 36(1):94-103. PMID: 18712382; PMCID: PMC2842018.
    75. Natarajan A, Kumaresan PR, Denardo SJ, Denardo GL, Mirick G, Lam KS. Development of TNKase-specific cleavable peptide-linked radioimmunoconjugates for radioimmunotherapy. Bioorg Med Chem Lett. 2008 Sep 01; 18(17):4802-5. PMID: 18701282.
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    76. Li B, An HJ, Kirmiz C, Lebrilla CB, Lam KS, Miyamoto S. Glycoproteomic analyses of ovarian cancer cell lines and sera from ovarian cancer patients show distinct glycosylation changes in individual proteins. J Proteome Res. 2008 Sep; 7(9):3776-88. PMID: 18642944.
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    77. Saegusa J, Akakura N, Wu CY, Hoogland C, Ma Z, Lam KS, Liu FT, Takada YK, Takada Y. Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner. J Biol Chem. 2008 Sep 19; 283(38):26107-15. PMID: 18635536; PMCID: PMC2533795.
    78. Luo J, Zhang H, Xiao W, Kumaresan PR, Shi C, Pan CX, Aina OH, Lam KS. Rainbow beads: a color coding method to facilitate high-throughput screening and optimization of one-bead one-compound combinatorial libraries. J Comb Chem. 2008 Jul-Aug; 10(4):599-604. PMID: 18558750.
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    79. Mori S, Wu CY, Yamaji S, Saegusa J, Shi B, Ma Z, Kuwabara Y, Lam KS, Isseroff RR, Takada YK, Takada Y. Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. J Biol Chem. 2008 Jun 27; 283(26):18066-75. PMID: 18441324; PMCID: PMC2440593.
    80. Peng L, Liu R, Andrei M, Xiao W, Lam KS. In vivo optical imaging of human lymphoma xenograft using a library-derived peptidomimetic against alpha4beta1 integrin. Mol Cancer Ther. 2008 Feb; 7(2):432-7. PMID: 18245670.
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    81. Kappel JC, Fan YC, Lam KS. Global transformation of OBOC combinatorial peptide libraries into OBOC polyamine and small molecule libraries. J Comb Chem. 2008 Mar-Apr; 10(2):333-42. PMID: 18181577.
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    82. Yao N, Wu CY, Xiao W, Lam KS. Discovery of high-affinity peptide ligands for vancomycin. Biopolymers. 2008; 90(3):421-32. PMID: 18260149.
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    83. Miyamoto S, Liu R, Hung S, Wang X, Lam KS. Screening of a one bead-one compound combinatorial library for beta-actin identifies molecules active toward Ramos B-lymphoma cells. Anal Biochem. 2008 Mar 01; 374(1):112-20. PMID: 18023409; PMCID: PMC2770001.
    84. Maezawa I, Hong HS, Liu R, Wu CY, Cheng RH, Kung MP, Kung HF, Lam KS, Oddo S, Laferla FM, Jin LW. Congo red and thioflavin-T analogs detect Abeta oligomers. J Neurochem. 2008 Jan; 104(2):457-68. PMID: 17953662.
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    85. Aina OH, Liu R, Sutcliffe JL, Marik J, Pan CX, Lam KS. From combinatorial chemistry to cancer-targeting peptides. Mol Pharm. 2007 Sep-Oct; 4(5):631-51. PMID: 17880166.
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    86. Leung PS, Park O, Tsuneyama K, Kurth MJ, Lam KS, Ansari AA, Coppel RL, Gershwin ME. Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization. J Immunol. 2007 Aug 15; 179(4):2651-7. PMID: 17675529.
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    87. Yao N, Song A, Wang X, Dixon S, Lam KS. Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries. J Comb Chem. 2007 Jul-Aug; 9(4):668-76. PMID: 17487987.
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    88. Kumaresan PR, Natarajan A, Song A, Wang X, Liu R, DeNardo G, DeNardo S, Lam KS. Development of tissue plasminogen activator specific "on demand cleavable" (odc) linkers for radioimmunotherapy by screening one-bead-one-compound combinatorial peptide libraries. Bioconjug Chem. 2007 Jan-Feb; 18(1):175-82. PMID: 17226971.
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    89. Hong HS, Maezawa I, Yao N, Xu B, Diaz-Avalos R, Rana S, Hua DH, Cheng RH, Lam KS, Jin LW. Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity. Brain Res. 2007 Jan 26; 1130(1):223-34. PMID: 17157826; PMCID: PMC1880896.
    90. Izumiya Y, Izumiya C, Van Geelen A, Wang DH, Lam KS, Luciw PA, Kung HJ. Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP. J Virol. 2007 Feb; 81(3):1072-82. PMID: 17108053; PMCID: PMC1797516.
    91. Lehman A, Gholami S, Hahn M, Lam KS. Image subtraction approach to screening one-bead-one-compound combinatorial libraries with complex protein mixtures. J Comb Chem. 2006 Jul-Aug; 8(4):562-70. PMID: 16827569.
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    92. Peng L, Liu R, Marik J, Wang X, Takada Y, Lam KS. Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging. Nat Chem Biol. 2006 Jul; 2(7):381-9. PMID: 16767086.
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    93. Kumaresan PR, Lam KS. Screening chemical microarrays: methods and applications. Mol Biosyst. 2006 May; 2(5):259-70. PMID: 16880944.
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    94. Liu R, Peng L, Han H, Lam KS. Structure-activity relationship studies of a series of peptidomimetic ligands for alpha(4) beta(1) integrin on Jurkat T-leukemia cells. Biopolymers. 2006; 84(6):595-604. PMID: 17041919.
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    95. Aina OH, Marik J, Liu R, Lau DH, Lam KS. Identification of novel targeting peptides for human ovarian cancer cells using "one-bead one-compound" combinatorial libraries. Mol Cancer Ther. 2005 May; 4(5):806-13. PMID: 15897245.
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    96. Wang X, Peng L, Liu R, Gill SS, Lam KS. Partial alloc-deprotection approach for ladder synthesis of "one-bead one-compound" combinatorial libraries. J Comb Chem. 2005 Mar-Apr; 7(2):197-209. PMID: 15762747.
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    97. Marik J, Lam KS. Peptide and small-molecule microarrays. Methods Mol Biol. 2005; 310:217-26. PMID: 16353378.
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    98. Martel CL, Li Y, Beckett L, Chew H, Christensen S, Davies A, Lam KS, Lau DH, Meyers FJ, O'donnell RT, Richman C, Scudder S, Tanaka M, Tuscano J, Welborn J, Wun T, Gandara DR, Lara PN. An evaluation of barriers to accrual in the era of legislation requiring insurance coverage of cancer clinical trial costs in California. Cancer J. 2004 Sep-Oct; 10(5):294-300. PMID: 15530258.
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    99. Song A, Zhang J, Lebrilla CB, Lam KS. Solid-phase synthesis and spectral properties of 2-alkylthio-6H-pyrano[2,3-f]benzimidazole-6-ones: a combinatorial approach for 2-alkylthioimidazocoumarins. J Comb Chem. 2004 Jul-Aug; 6(4):604-10. PMID: 15244422.
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    100. Wang X, Zhang J, Song A, Lebrilla CB, Lam KS. Encoding method for OBOC small molecule libraries using a biphasic approach for ladder-synthesis of coding tags. J Am Chem Soc. 2004 May 12; 126(18):5740-9. PMID: 15125667.
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    101. Liu R, Hsieh CY, Lam KS. New approaches in identifying drugs to inactivate oncogene products. Semin Cancer Biol. 2004 Feb; 14(1):13-21. PMID: 14757532.
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    102. Song A, Wang X, Zhang J, Marík J, Lebrilla CB, Lam KS. Synthesis of hydrophilic and flexible linkers for peptide derivatization in solid phase. Bioorg Med Chem Lett. 2004 Jan 05; 14(1):161-5. PMID: 14684320.
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    103. Xu Q, Miyamoto S, Lam KS. A novel approach to chemical microarray using ketone-modified macromolecular scaffolds: application in micro cell-adhesion assay. Mol Divers. 2004; 8(3):301-10. PMID: 15384423.
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    104. Song A, Zhang J, Lam KS. Synthesis and reactions of 7-fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran-3-carboxylic acid: a novel scaffold for combinatorial synthesis of coumarins. J Comb Chem. 2004 Jan-Feb; 6(1):112-20. PMID: 14714994.
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    105. DeNardo SJ, Yao Z, Lam KS, Song A, Burke PA, Mirick GR, Lamborn KR, O'Donnell RT, DeNardo GL. Effect of molecular size of pegylated peptide on the pharmacokinetics and tumor targeting in lymphoma-bearing mice. Clin Cancer Res. 2003 Sep 01; 9(10 Pt 2):3854S-64S. PMID: 14506183.
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    106. DeNardo GL, DeNardo SJ, Peterson JJ, Miers LA, Lam KS, Hartmann-Siantar C, Lamborn KR. Preclinical evaluation of cathepsin-degradable peptide linkers for radioimmunoconjugates. Clin Cancer Res. 2003 Sep 01; 9(10 Pt 2):3865S-72S. PMID: 14506184.
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    107. Lam KS, Liu R, Miyamoto S, Lehman AL, Tuscano JM. Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research. Acc Chem Res. 2003 Jun; 36(6):370-7. PMID: 12809522.
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    108. Song A, Zhang J, Lebrilla CB, Lam KS. A novel and rapid encoding method based on mass spectrometry for "one-bead-one-compound" small molecule combinatorial libraries. J Am Chem Soc. 2003 May 21; 125(20):6180-8. PMID: 12785850.
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    109. Leung PS, Quan C, Park O, Van de Water J, Kurth MJ, Nantz MH, Ansari AA, Coppel RL, Lam KS, Gershwin ME. Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies. J Immunol. 2003 May 15; 170(10):5326-32. PMID: 12734383.
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    110. Liu R, Enstrom AM, Lam KS. Combinatorial peptide library methods for immunobiology research. Exp Hematol. 2003 Jan; 31(1):11-30. PMID: 12543103.
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    111. Liu R, Marik J, Lam KS. Design, synthesis, screening, and decoding of encoded one-bead one-compound peptidomimetic and small molecule combinatorial libraries. Methods Enzymol. 2003; 369:271-87. PMID: 14722959.
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    112. Lam KS, Lehman AL, Song A, Doan N, Enstrom AM, Maxwell J, Liu R. Synthesis and screening of "one-bead one-compound" combinatorial peptide libraries. Methods Enzymol. 2003; 369:298-322. PMID: 14722961.
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    113. Liu R, Marik J, Lam KS. A novel peptide-based encoding system for "one-bead one-compound" peptidomimetic and small molecule combinatorial libraries. J Am Chem Soc. 2002 Jul 03; 124(26):7678-80. PMID: 12083920.
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    114. Lam KS, Renil M. From combinatorial chemistry to chemical microarray. Curr Opin Chem Biol. 2002 Jun; 6(3):353-8. PMID: 12023117.
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    115. Wu JJ, Afar DE, Phan H, Witte ON, Lam KS. Recognition of multiple substrate motifs by the c-ABL protein tyrosine kinase. Comb Chem High Throughput Screen. 2002 Feb; 5(1):83-91. PMID: 11860343.
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    116. Aina OH, Sroka TC, Chen ML, Lam KS. Therapeutic cancer targeting peptides. Biopolymers. 2002; 66(3):184-99. PMID: 12385037.
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