Kent Leach

Title(s)Department Vice Chair, Orthopaedic Surgery
SchoolSchool of Medicine
AddressOPRB 2409
CA 95817
Phone916-734-8965
ORCID ORCID Icon0000-0002-1673-3335 Additional info
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    Title(s)Professor, Orthopaedic Surgery


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Compliant substrates mitigate the senescence associated phenotype of stress induced mesenchymal stromal cells. J Biomed Mater Res A. 2024 May; 112(5):770-780. Gresham RCH, Filler AC, Fok SW, Czachor M, Schmier N, Pearson C, Bahney C, Leach JK. PMID: 38095311; PMCID: PMC10948313.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Conductive Microgel Annealed Scaffolds Enhance Myogenic Potential of Myoblastic Cells. Adv Healthc Mater. 2023 Dec 09; e2302500. Casella A, Lowen J, Griffin KH, Shimamoto N, Ramos-Rodriguez DH, Panitch A, Leach JK. PMID: 38069833.
      View in: PubMed   Mentions: 1     Fields:    
    3. The critical impact of traumatic muscle loss on fracture healing: Basic science and clinical aspects. J Orthop Res. 2024 02; 42(2):249-258. Rahmati M, Haffner M, Lee MA, Leach JK, Saiz AM. PMID: 37990953.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening. Proc Natl Acad Sci U S A. 2023 09 26; 120(39):e2302101120. Griffin KH, Thorpe SW, Sebastian A, Hum NR, Coonan TP, Sagheb IS, Loots GG, Randall RL, Leach JK. PMID: 37729195; PMCID: PMC10523456.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. Hydrogel degradation promotes angiogenic and regenerative potential of cell spheroids for wound healing. Mater Today Bio. 2023 Oct; 22:100769. Thai VL, Ramos-Rodriguez DH, Mesfin M, Leach JK. PMID: 37636986; PMCID: PMC10450977.
      View in: PubMed   Mentions: 2  
    6. Conductive microgel annealed scaffolds enhance myogenic potential of myoblastic cells. bioRxiv. 2023 Aug 03. Casella A, Lowen J, Shimamoto N, Griffin KH, Filler AC, Panitch A, Leach JK. PMID: 37577583; PMCID: PMC10418230.
      View in: PubMed   Mentions:
    7. Prostate cancer and bone: clinical presentation and molecular mechanisms. Endocr Relat Cancer. 2023 09 01; 30(9). Wells KV, Krackeler ML, Jathal MK, Parikh M, Ghosh PM, Leach JK, Genetos DC. PMID: 37226936; PMCID: PMC10696925.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Biomaterials are the key to unlock spheroid function and therapeutic potential. Biomater Biosyst. 2023 Sep; 11:100080. Ramos-Rodriguez DH, Leach JK. PMID: 37720486; PMCID: PMC10499638.
      View in: PubMed   Mentions: 1  
    9. The Year 2022 in biomaterials research: A perspective from the editors of six leading journals. J Biomed Mater Res A. 2023 09; 111(9):1298-1308. Stegemann JP, Wagner WR, Göbel U, Perets E, Leong KW, Leach JK, Gilbert J. PMID: 36951261.
      View in: PubMed   Mentions:    Fields:    
    10. Special issue: Emerging scholars in biomaterials. J Biomed Mater Res A. 2023 06; 111(6):746. Leach JK, Lewis JS. PMID: 36932829.
      View in: PubMed   Mentions:    Fields:    
    11. Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids. Ann Biomed Eng. 2023 Jul; 51(7):1558-1573. Thai VL, Candelas DO, Leach JK. PMID: 36809393; PMCID: PMC10264490.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. Multisized Photoannealable Microgels Regulate Cell Spreading, Aggregation, and Macrophage Phenotype through Microporous Void Space. Adv Healthc Mater. 2023 05; 12(13):e2202239. Lowen JM, Bond GC, Griffin KH, Shimamoto NK, Thai VL, Leach JK. PMID: 36719946; PMCID: PMC10198868.
      View in: PubMed   Mentions: 6     Fields:    
    13. Macromolecular crowding and decellularization method increase the growth factor binding potential of cell-secreted extracellular matrices. Front Bioeng Biotechnol. 2023; 11:1091157. Fok SW, Gresham RCH, Ryan W, Osipov B, Bahney C, Leach JK. PMID: 36756385; PMCID: PMC9899907.
      View in: PubMed   Mentions:
    14. Electroconductive agarose hydrogels modulate mesenchymal stromal cell adhesion and spreading through protein adsorption. J Biomed Mater Res A. 2023 05; 111(5):596-608. Casella A, Panitch A, Leach JK. PMID: 36680496; PMCID: PMC10023318.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Mesenchymal stromal cell spheroids in sulfated alginate enhance muscle regeneration. Acta Biomater. 2023 01 01; 155:271-281. Gionet-Gonzales MA, Gresham RCH, Griffin KH, Casella A, Wohlgemuth RP, Ramos-Rodriguez DH, Lowen J, Smith LR, Leach JK. PMID: 36328130.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. Non-destructive, continuous monitoring of biochemical, mechanical, and structural maturation in engineered tissue. Sci Rep. 2022 09 28; 12(1):16227. Haudenschild AK, Sherlock BE, Zhou X, Sheaff CS, Hu JC, Leach JK, Marcu L, Athanasiou KA. PMID: 36171228; PMCID: PMC9519952.
      View in: PubMed   Mentions:    Fields:    
    17. Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair. Theranostics. 2022; 12(13):6021-6037. Hao D, Lu L, Song H, Duan Y, Chen J, Carney R, Li JJ, Zhou P, Nolta J, Lam KS, Leach JK, Farmer DL, Panitch A, Wang A. PMID: 35966577; PMCID: PMC9373818.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    18. Characterization of Induction and Targeting of Senescent Mesenchymal Stromal Cells. Tissue Eng Part C Methods. 2022 06; 28(6):239-249. Gresham RCH, Kumar D, Copp J, Lee MA, Leach JK. PMID: 35438548; PMCID: PMC9247679.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    19. A bioactive material with dual integrin-targeting ligands regulates specific endogenous cell adhesion and promotes vascularized bone regeneration in adult and fetal bone defects. Bioact Mater. 2023 Feb; 20:179-193. Hao D, Liu R, Fernandez TG, Pivetti C, Jackson JE, Kulubya ES, Jiang HJ, Ju HY, Liu WL, Panitch A, Lam KS, Leach JK, Farmer DL, Wang A. PMID: 35663336; PMCID: PMC9160290.
      View in: PubMed   Mentions: 4  
    20. Engineered Cell-Secreted Extracellular Matrix Modulates Cell Spheroid Mechanosensing and Amplifies Their Response to Inductive Cues for the Formation of Mineralized Tissues. Adv Healthc Mater. 2022 05; 11(10):e2102337. Gonzalez-Fernandez T, Tenorio AJ, Saiz AM, Leach JK. PMID: 34968011; PMCID: PMC9117430.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    21. Amplifying the voice of the Early Career Scientist through the inaugural Early Career Editorial Board. J Biomed Mater Res A. 2022 01; 110(1):7-10. Leach JK. PMID: 34672093; PMCID: PMC8794307.
      View in: PubMed   Mentions:    Fields:    
    22. Sulfated Alginate Hydrogels Prolong the Therapeutic Potential of MSC Spheroids by Sequestering the Secretome. Adv Healthc Mater. 2021 11; 10(21):e2101048. Gionet-Gonzales M, Casella A, Diloretto D, Ginnell C, Griffin KH, Bigot A, Leach JK. PMID: 34486244; PMCID: PMC8568671.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    23. Skeletal muscle progenitors are sensitive to collagen architectural features of fibril size and cross linking. Am J Physiol Cell Physiol. 2021 08 01; 321(2):C330-C342. Hu LY, Mileti CJ, Loomis T, Brashear SE, Ahmad S, Chellakudam RR, Wohlgemuth RP, Gionet-Gonzales MA, Leach JK, Smith LR. PMID: 34191625; PMCID: PMC8424678.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    24. Endogenous Electric Signaling as a Blueprint for Conductive Materials in Tissue Engineering. Bioelectricity. 2021 Mar 01; 3(1):27-41. Casella A, Panitch A, Leach JK. PMID: 34476376; PMCID: PMC8370482.
      View in: PubMed   Mentions: 9  
    25. Alginate-Based Bioinks for 3D Bioprinting and Fabrication of Anatomically Accurate Bone Grafts. Tissue Eng Part A. 2021 09; 27(17-18):1168-1181. Gonzalez-Fernandez T, Tenorio AJ, Campbell KT, Silva EA, Leach JK. PMID: 33218292; PMCID: PMC8558068.
      View in: PubMed   Mentions: 15     Fields:    
    26. Mechanical Load Regulates Excitation-Ca2+ Signaling-Contraction in Cardiomyocyte. Circ Res. 2021 03 19; 128(6):772-774. Shimkunas R, Hegyi B, Jian Z, Shaw JA, Kazemi-Lari MA, Mitra D, Leach JK, Li X, Jaradeh M, Balardi N, Chen YJ, Escobar AL, Baker AJ, Bossuyt J, Banyasz T, Chiamvimonvat N, Lam KS, Bers DM, Izu LT, Chen-Izu Y. PMID: 33601939; PMCID: PMC7979518.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    27. Passing the torch of the Journal of Biomedical Materials Research-Part A. J Biomed Mater Res A. 2021 04; 109(4):395-396. Leach JK. PMID: 33559372.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Tissue engineered platforms for studying primary and metastatic neoplasm behavior in bone. J Biomech. 2021 01 22; 115:110189. Thai VL, Griffin KH, Thorpe SW, Randall RL, Leach JK. PMID: 33385867; PMCID: PMC7855491.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    29. Growth factor delivery using extracellular matrix-mimicking substrates for musculoskeletal tissue engineering and repair. Bioact Mater. 2021 Jul; 6(7):1945-1956. Gresham RCH, Bahney CS, Leach JK. PMID: 33426369; PMCID: PMC7773685.
      View in: PubMed   Mentions: 27  
    30. Hydrogel mechanics are a key driver of bone formation by mesenchymal stromal cell spheroids. Biomaterials. 2021 02; 269:120607. Whitehead J, Griffin KH, Gionet-Gonzales M, Vorwald CE, Cinque SE, Leach JK. PMID: 33385687; PMCID: PMC7870573.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    31. Three-Dimensional Printed Stamps for the Fabrication of Patterned Microwells and High-Throughput Production of Homogeneous Cell Spheroids. 3D Print Addit Manuf. 2020 Jun 01; 7(3):139-147. Gonzalez-Fernandez T, Tenorio AJ, Leach JK. PMID: 32855996; PMCID: PMC7313638.
      View in: PubMed   Mentions: 9  
    32. Multi-peptide presentation and hydrogel mechanics jointly enhance therapeutic duo-potential of entrapped stromal cells. Biomaterials. 2020 07; 245:119973. Hung BP, Gonzalez-Fernandez T, Lin JB, Campbell T, Lee YB, Panitch A, Alsberg E, Leach JK. PMID: 32244091; PMCID: PMC7183241.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    33. Tunable fibrin-alginate interpenetrating network hydrogels to support cell spreading and network formation. Acta Biomater. 2020 05; 108:142-152. Vorwald CE, Gonzalez-Fernandez T, Joshee S, Sikorski P, Leach JK. PMID: 32173582; PMCID: PMC7198331.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    34. Functionally graded biomaterials for use as model systems and replacement tissues. Adv Funct Mater. 2020 Oct 28; 30(44). Lowen JM, Leach JK. PMID: 33456431; PMCID: PMC7810245.
      View in: PubMed   Mentions: 17  
    35. Osteogenic preconditioning in perfusion bioreactors improves vascularization and bone formation by human bone marrow aspirates. Sci Adv. 2020 02; 6(7):eaay2387. Harvestine JN, Gonzalez-Fernandez T, Sebastian A, Hum NR, Genetos DC, Loots GG, Leach JK. PMID: 32095526; PMCID: PMC7015678.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    36. Spatial localization of endothelial cells in heterotypic spheroids influences Notch signaling. J Mol Med (Berl). 2020 03; 98(3):425-435. Vorwald CE, Joshee S, Leach JK. PMID: 32020237; PMCID: PMC7083693.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    37. Morphogen Delivery by Osteoconductive Nanoparticles Instructs Stromal Cell Spheroid Phenotype. Adv Biosyst. 2019 12; 3(12). Whitehead J, Kothambawala A, Leach JK. PMID: 32270027; PMCID: PMC7141413.
      View in: PubMed   Mentions: 7     Fields:    
    38. Tunneling nanotubes mediate the expression of senescence markers in mesenchymal stem/stromal cell spheroids. Stem Cells. 2020 01; 38(1):80-89. Whitehead J, Zhang J, Harvestine JN, Kothambawala A, Liu GY, Leach JK. PMID: 31298767; PMCID: PMC6954984.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    39. Bio-instructive materials for musculoskeletal regeneration. Acta Biomater. 2019 09 15; 96:20-34. Gonzalez-Fernandez T, Sikorski P, Leach JK. PMID: 31302298; PMCID: PMC6717669.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    40. Is Tissue Engineering Helping Orthopaedic Care in Trauma? J Orthop Trauma. 2019 Jun; 33 Suppl 6:S12-S19. Crist BD, Leach JK, Lee MA. PMID: 31083143.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    41. Conditioning of myoblast secretome using mesenchymal stem/stromal cell spheroids improves bone repair. Bone. 2019 08; 125:151-159. Saiz AM, Gionet-Gonzales MA, Lee MA, Leach JK. PMID: 31102712; PMCID: PMC6589400.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    42. Cell-secreted extracellular matrix influences cellular composition sequestered from unprocessed bone marrow aspirate for osteogenic grafts. Biomater Sci. 2019 Apr 23; 7(5):2091-2101. Harvestine JN, Saiz Jr AM, Leach JK. PMID: 30869662; PMCID: PMC6478553.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    43. Multimodal Label-Free Imaging for Detecting Maturation of Engineered Osteogenic Grafts. ACS Biomater Sci Eng. 2019 Apr 08; 5(4):1956-1966. Harvestine JN, Sheaff CS, Li C, Haudenschild AK, Gionet-Gonzales MA, Hu JC, Athanasiou KA, Marcu L, Leach JK. PMID: 33405522; PMCID: PMC8594456.
      View in: PubMed   Mentions: 3     Fields:    
    44. Non-destructive detection of matrix stabilization correlates with enhanced mechanical properties of self-assembled articular cartilage. J Tissue Eng Regen Med. 2019 04; 13(4):637-648. Haudenschild AK, Sherlock BE, Zhou X, Hu JC, Leach JK, Marcu L, Athanasiou KA. PMID: 30770656; PMCID: PMC6461514.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    45. Injectable mineralized microsphere-loaded composite hydrogels for bone repair in a sheep bone defect model. Biomaterials. 2019 03; 197:119-128. Ingavle GC, Gionet-Gonzales M, Vorwald CE, Bohannon LK, Clark K, Galuppo LD, Leach JK. PMID: 30641263; PMCID: PMC6363840.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    46. Detection of glycosaminoglycan loss in articular cartilage by fluorescence lifetime imaging. J Biomed Opt. 2018 12; 23(12):1-8. Zhou X, Haudenschild AK, Sherlock BE, Hu JC, Leach JK, Athanasiou KA, Marcu L. PMID: 30578627; PMCID: PMC8357192.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    47. Direct Observation of Tunneling Nanotubes within Human Mesenchymal Stem Cell Spheroids. J Phys Chem B. 2018 11 01; 122(43):9920-9926. Zhang J, Whitehead J, Liu Y, Yang Q, Leach JK, Liu GY. PMID: 30350968.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    48. Defining hydrogel properties to instruct lineage- and cell-specific mesenchymal differentiation. Biomaterials. 2019 01; 189:1-10. Hung BP, Harvestine JN, Saiz AM, Gonzalez-Fernandez T, Sahar DE, Weiss ML, Leach JK. PMID: 30384124; PMCID: PMC6237198.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    49. Exogenous Lysyl Oxidase-Like 2 and Perfusion Culture Induce Collagen Crosslink Formation in Osteogenic Grafts. Biotechnol J. 2019 Mar; 14(3):e1700763. Mitra D, Yasui OW, Harvestine JN, Link JM, Hu JC, Athanasiou KA, Leach JK. PMID: 30052320; PMCID: PMC6432926.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    50. Nondestructive fluorescence lifetime imaging and time-resolved fluorescence spectroscopy detect cartilage matrix depletion and correlate with mechanical properties. Eur Cell Mater. 2018 07 27; 36:30-43. Haudenschild AK, Sherlock BE, Zhou X, Hu JC, Leach JK, Marcu L, Athanasiou KA. PMID: 30051455.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    51. Hypoxic Preconditioning of Mesenchymal Stem Cells with Subsequent Spheroid Formation Accelerates Repair of Segmental Bone Defects. Stem Cells. 2018 09; 36(9):1393-1403. Ho SS, Hung BP, Heyrani N, Lee MA, Leach JK. PMID: 29968952; PMCID: PMC6125201.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    52. Cell-secreted extracellular matrix, independent of cell source, promotes the osteogenic differentiation of human stromal vascular fraction. J Mater Chem B. 2018 Jun 28; 6(24):4104-4115. Harvestine JN, Orbay H, Chen JY, Sahar DE, Leach JK. PMID: 30505446; PMCID: PMC6261520.
      View in: PubMed   Mentions: 16     Fields:    
    53. Restoring vasculogenic potential of endothelial cells from diabetic patients through spheroid formation. Cell Mol Bioeng. 2018 Aug; 11(4):267-278. Vorwald CE, Murphy KC, Leach JK. PMID: 30416603; PMCID: PMC6223260.
      View in: PubMed   Mentions: 9  
    54. Engineering principles for guiding spheroid function in the regeneration of bone, cartilage, and skin. Biomed Mater. 2018 03 21; 13(3):034109. Gionet-Gonzales MA, Leach JK. PMID: 29460842; PMCID: PMC5898817.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    55. Nondestructive assessment of collagen hydrogel cross-linking using time-resolved autofluorescence imaging. J Biomed Opt. 2018 03; 23(3):1-9. Sherlock BE, Harvestine JN, Mitra D, Haudenschild A, Hu J, Athanasiou KA, Leach JK, Marcu L. PMID: 29512359; PMCID: PMC5839417.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    56. High-Throughput Formation of Mesenchymal Stem Cell Spheroids and Entrapment in Alginate Hydrogels. Methods Mol Biol. 2018; 1758:139-149. Vorwald CE, Ho SS, Whitehead J, Leach JK. PMID: 29679328; PMCID: PMC6764926.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    57. Cell Migration and Bone Formation from Mesenchymal Stem Cell Spheroids in Alginate Hydrogels Are Regulated by Adhesive Ligand Density. Biomacromolecules. 2017 Dec 11; 18(12):4331-4340. Ho SS, Keown AT, Addison B, Leach JK. PMID: 29131587; PMCID: PMC5971090.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    58. Engineering fibrin hydrogels to promote the wound healing potential of mesenchymal stem cell spheroids. Acta Biomater. 2017 12; 64:176-186. Murphy KC, Whitehead J, Zhou D, Ho SS, Leach JK. PMID: 28987783; PMCID: PMC5682213.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    59. The Effects of Adipose-Derived Stem Cells Differentiated Into Endothelial Cells and Osteoblasts on Healing of Critical Size Calvarial Defects. J Craniofac Surg. 2017 Oct; 28(7):1874-1879. Orbay H, Busse B, Leach JK, Sahar DE. PMID: 28872512.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    60. Bioreactor culture duration of engineered constructs influences bone formation by mesenchymal stem cells. Biomaterials. 2017 Nov; 146:29-39. Mitra D, Whitehead J, Yasui OW, Leach JK. PMID: 28898756; PMCID: PMC5618709.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    61. Supersonic transient magnetic resonance elastography for quantitative assessment of tissue elasticity. Phys Med Biol. 2017 05 21; 62(10):4083-4106. Liu Y, Liu J, Fite BZ, Foiret J, Ilovitsh A, Leach JK, Dumont E, Caskey CF, Ferrara KW. PMID: 28426437; PMCID: PMC5545104.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    62. Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids. Stem Cells. 2017 06; 35(6):1493-1504. Murphy KC, Whitehead J, Falahee PC, Zhou D, Simon SI, Leach JK. PMID: 28276602; PMCID: PMC5446296.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    63. Materials-Directed Differentiation of Mesenchymal Stem Cells for Tissue Engineering and Regeneration. ACS Biomater Sci Eng. 2018 Apr 09; 4(4):1115-1127. Leach JK, Whitehead J. PMID: 30035212; PMCID: PMC6052883.
      View in: PubMed   Mentions: 45     Fields:    
    64. Measurement of oxygen tension within mesenchymal stem cell spheroids. J R Soc Interface. 2017 02; 14(127). Murphy KC, Hung BP, Browne-Bourne S, Zhou D, Yeung J, Genetos DC, Leach JK. PMID: 28179546; PMCID: PMC5332570.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    65. Extracellular Matrix-Coated Composite Scaffolds Promote Mesenchymal Stem Cell Persistence and Osteogenesis. Biomacromolecules. 2016 11 14; 17(11):3524-3531. Harvestine JN, Vollmer NL, Ho SS, Zikry CA, Lee MA, Leach JK. PMID: 27744699.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    66. Effect of encapsulation on plasminogen activator delivery to the microcirculation and its implications for bleeding. Clin Hemorheol Microcirc. 2016 Oct 05; 63(4):373-379. Thummala AS, Leach JK, Patterson E, O'Rear EA. PMID: 26890102.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    67. Bone Morphogenetic Protein-2 Promotes Human Mesenchymal Stem Cell Survival and Resultant Bone Formation When Entrapped in Photocrosslinked Alginate Hydrogels. Adv Healthc Mater. 2016 10; 5(19):2501-2509. Ho SS, Vollmer NL, Refaat MI, Jeon O, Alsberg E, Lee MA, Leach JK. PMID: 27581621; PMCID: PMC5176258.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    68. Binding to COMP Reduces the BMP2 Dose for Spinal Fusion in a Rat Model. Spine (Phila Pa 1976). 2016 Jul 15; 41(14):E829-E836. Refaat M, Klineberg EO, Fong MC, Garcia TC, Leach JK, Haudenschild DR. PMID: 26679888; PMCID: PMC7054986.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    69. Mesenchymal Stem Cell Spheroids Retain Osteogenic Phenotype Through α2β1 Signaling. Stem Cells Transl Med. 2016 09; 5(9):1229-37. Murphy KC, Hoch AI, Harvestine JN, Zhou D, Leach JK. PMID: 27365484; PMCID: PMC4996446.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    70. Detection of Pentosidine Cross-Links in Cell-Secreted Decellularized Matrices Using Time Resolved Fluorescence Spectroscopy. ACS Biomater Sci Eng. 2017 Sep 11; 3(9):1944-1954. Mitra D, Fatakdawala H, Nguyen-Truong M, Creecy A, Nyman J, Marcu L, Leach JK. PMID: 28944287; PMCID: PMC5604893.
      View in: PubMed   Mentions: 9     Fields:    
    71. Increased Survival and Function of Mesenchymal Stem Cell Spheroids Entrapped in Instructive Alginate Hydrogels. Stem Cells Transl Med. 2016 Jun; 5(6):773-81. Ho SS, Murphy KC, Binder BY, Vissers CB, Leach JK. PMID: 27057004; PMCID: PMC4878334.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    72. Neurogenic potential of engineered mesenchymal stem cells overexpressing VEGF. Cell Mol Bioeng. 2016 Mar 01; 9(1):96-106. Man AJ, Kujawski G, Burns TS, Miller EN, Fierro FA, Leach JK, Bannerman P. PMID: 27087859; PMCID: PMC4830493.
      View in: PubMed   Mentions: 8  
    73. Tissue Engineering a Biological Repair Strategy for Lumbar Disc Herniation. Biores Open Access. 2015; 4(1):431-45. O'Connell GD, Leach JK, Klineberg EO. PMID: 26634189; PMCID: PMC4652242.
      View in: PubMed   Mentions: 12  
    74. Cell-secreted matrices perpetuate the bone-forming phenotype of differentiated mesenchymal stem cells. Biomaterials. 2016 Jan; 74:178-87. Hoch AI, Mittal V, Mitra D, Vollmer N, Zikry CA, Leach JK. PMID: 26457835; PMCID: PMC4661076.
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    75. Pore size regulates mesenchymal stem cell response to Bioglass-loaded composite scaffolds. J Mater Chem B. 2015 Nov 28; 3(44):8650-8658. Vissers CAB, Harvestine JN, Leach JK. PMID: 32262722.
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    77. Lysophosphatidic Acid and Sphingosine-1-Phosphate: A Concise Review of Biological Function and Applications for Tissue Engineering. Tissue Eng Part B Rev. 2015 Dec; 21(6):531-42. Binder BY, Williams PA, Silva EA, Leach JK. PMID: 26035484; PMCID: PMC4663652.
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    78. Reduced serum and hypoxic culture conditions enhance the osteogenic potential of human mesenchymal stem cells. Stem Cell Rev Rep. 2015 Jun; 11(3):387-93. Binder BY, Sagun JE, Leach JK. PMID: 25173881; PMCID: PMC4345153.
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    79. Concise review: optimizing expansion of bone marrow mesenchymal stem/stromal cells for clinical applications. Stem Cells Transl Med. 2015 Apr; 4(4):412. Hoch AI, Leach JK. PMID: 25795657; PMCID: PMC4367501.
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    82. Implantable biomaterial based on click chemistry for targeting small molecules. Acta Biomater. 2014 Dec; 10(12):5099-5105. Mejía Oneto JM, Gupta M, Leach JK, Lee M, Sutcliffe JL. PMID: 25162537.
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    83. Human mesenchymal stem cell spheroids in fibrin hydrogels exhibit improved cell survival and potential for bone healing. Cell Tissue Res. 2014 Jul; 357(1):91-9. Murphy KC, Fang SY, Leach JK. PMID: 24781147; PMCID: PMC4077909.
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    84. Ultrastructure and growth factor content of equine platelet-rich fibrin gels. Am J Vet Res. 2014 Apr; 75(4):392-401. Textor JA, Murphy KC, Leach JK, Tablin F. PMID: 24669926.
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    85. Concise review: optimizing expansion of bone marrow mesenchymal stem/stromal cells for clinical applications. Stem Cells Transl Med. 2014 May; 3(5):643-52. Hoch AI, Leach JK. PMID: 24682286; PMCID: PMC4006491.
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    86. Remineralized bone matrix as a scaffold for bone tissue engineering. J Biomed Mater Res A. 2014 Dec; 102(12):4480-90. Soicher MA, Christiansen BA, Stover SM, Leach JK, Yellowley CE, Griffiths LG, Fyhrie DP. PMID: 24616346; PMCID: PMC4145060.
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    87. Redirection of neurite outgrowth by coupling chondroitin sulfate proteoglycans to polymer membranes. Ann Biomed Eng. 2014 Jun; 42(6):1271-81. Man AJ, Leach JK, Bannerman P. PMID: 24570390.
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    88. Lysophosphatidic acid protects human mesenchymal stromal cells from differentiation-dependent vulnerability to apoptosis. Tissue Eng Part A. 2014 Apr; 20(7-8):1156-64. Binder BY, Genetos DC, Leach JK. PMID: 24131310; PMCID: PMC3993074.
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    89. Enhanced trophic factor secretion by mesenchymal stem/stromal cells with Glycine-Histidine-Lysine (GHK)-modified alginate hydrogels. Acta Biomater. 2014 May; 10(5):1955-64. Jose S, Hughbanks ML, Binder BY, Ingavle GC, Leach JK. PMID: 24468583; PMCID: PMC3976757.
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    90. Lysophosphatidic acid enhances stromal cell-directed angiogenesis. PLoS One. 2013; 8(12):e82134. Binder BY, Sondergaard CS, Nolta JA, Leach JK. PMID: 24312635; PMCID: PMC3846884.
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    91. Advancements in electrospinning of polymeric nanofibrous scaffolds for tissue engineering. Tissue Eng Part B Rev. 2014 Aug; 20(4):277-93. Ingavle GC, Leach JK. PMID: 24004443.
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    92. Alginate hydrogels containing cell-interactive beads for bone formation. FASEB J. 2013 Dec; 27(12):4844-52. Bhat A, Hoch AI, Decaris ML, Leach JK. PMID: 24005905.
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    93. Remineralization of demineralized bone matrix (DBM) via alternating solution immersion (ASI). J Mech Behav Biomed Mater. 2013 Oct; 26:109-18. Soicher MA, Christiansen BA, Stover SM, Leach JK, Fyhrie DP. PMID: 23759125; PMCID: PMC3713112.
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    94. Enhancing osteoconductivity of fibrin gels with apatite-coated polymer microspheres. Tissue Eng Part A. 2013 Aug; 19(15-16):1773-82. Davis HE, Binder BY, Schaecher P, Yakoobinsky DD, Bhat A, Leach JK. PMID: 23560390; PMCID: PMC3700018.
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    95. A reproducible, high throughput method for fabricating fibrin gels. BMC Res Notes. 2012 Aug 08; 5:423. Murphy KC, Leach JK. PMID: 22873708; PMCID: PMC3492004.
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    96. Cell-derived matrix coatings for polymeric scaffolds. Tissue Eng Part A. 2012 Oct; 18(19-20):2148-57. Decaris ML, Binder BY, Soicher MA, Bhat A, Leach JK. PMID: 22651377.
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    97. Bioceramic-mediated trophic factor secretion by mesenchymal stem cells enhances in vitro endothelial cell persistence and in vivo angiogenesis. Tissue Eng Part A. 2012 Jul; 18(13-14):1520-8. He J, Decaris ML, Leach JK. PMID: 22546052; PMCID: PMC3397122.
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    98. Ceramic identity contributes to mechanical properties and osteoblast behavior on macroporous composite scaffolds. J Funct Biomater. 2012 May 23; 3(2):382-97. Morales-Hernandez DG, Genetos DC, Working DM, Murphy KC, Leach JK. PMID: 24955539; PMCID: PMC4047943.
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    99. Differentiation-dependent secretion of proangiogenic factors by mesenchymal stem cells. PLoS One. 2012; 7(4):e35579. Hoch AI, Binder BY, Genetos DC, Leach JK. PMID: 22536411; PMCID: PMC3334972.
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    100. Transferable cell-secreted extracellular matrices enhance osteogenic differentiation. Acta Biomater. 2012 Feb; 8(2):744-52. Decaris ML, Mojadedi A, Bhat A, Leach JK. PMID: 22079209.
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    101. Differential growth factor adsorption to calvarial osteoblast-secreted extracellular matrices instructs osteoblastic behavior. PLoS One. 2011; 6(10):e25990. Bhat A, Boyadjiev SA, Senders CW, Leach JK. PMID: 21998741; PMCID: PMC3187840.
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    102. Neurite outgrowth in fibrin gels is regulated by substrate stiffness. Tissue Eng Part A. 2011 Dec; 17(23-24):2931-42. Man AJ, Davis HE, Itoh A, Leach JK, Bannerman P. PMID: 21882895.
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    103. The role of protein solubilization in antigen removal from xenogeneic tissue for heart valve tissue engineering. Biomaterials. 2011 Nov; 32(32):8129-38. Wong ML, Leach JK, Athanasiou KA, Griffiths LG. PMID: 21810537.
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    104. Multifunctional cell-instructive materials for tissue regeneration. Regen Med. 2006 Jul; 1(4):447-55. Leach JK. PMID: 17465837.
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