Blaine A Christiansen, PhD; MS

Title(s)Associate Professor, Orthopaedic Surgery
SchoolUniversity of California, Davis
Address4635 2nd Avenue, Room 2002
CA 95817
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    Collapse Biography 
    Collapse Education and Training
    University of Nebraska, Lincoln, NEBS12/2001Biological Systems Engineering
    Washington University, St. Louis, MOMS05/2004Biomedical Engineering
    Washington University, St. Louis, MOPh.D.12/2007Biomedical Engineering
    Beth Israel Deaconess Medical Center, Boston, MAPostdoctoral Fellowship02/2010Orthopaedic Research
    Collapse Awards and Honors
    American Society of Mechanical Engineers 2005Summer Bioengineering Conference, 1st Place - Student Paper Competition
    United States Bone and Joint Decade 2010  - 2011Young Investigators Initiative
    American Society for Bone and Mineral Research 2010Young Investigator Award
    International Bone and Mineral Society/American Society for Bone and Mineral Research2011Harold M. Frost Young Investigator Award
    American Society for Bone and Mineral Research2014Junior Faculty Osteoporosis Research Award
    International Bone and Mineral Society2014Alice L. Jee Memorial Young Investigator Award

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of Systemic Bone Loss Following Femur Fracture in Mice
    NIH/NIAMS R01AR071459Sep 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    The role of the inflammatory response in bone and cartilage changes following non
    NIH/NIAMS K01AR062603Sep 10, 2012 - Aug 31, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Systemic Bone Loss Following Myocardial Infarctionin Mice. J Orthop Res. 2020 Sep 23. Tjandra PM, Paralkar MP, Osipov B, Chen YJ, Zhao F, Ripplinger CM, Christiansen BA. PMID: 32965732.
      View in: PubMed   Mentions:    Fields:    
    2. Antibiotic Treatment Prior to Injury Improves Post-Traumatic Osteoarthritis Outcomes in Mice. Int J Mol Sci. 2020 Sep 03; 21(17). Mendez ME, Murugesh DK, Sebastian A, Hum NR, McCloy SA, Kuhn EA, Christiansen BA, Loots GG. PMID: 32899361.
      View in: PubMed   Mentions:    Fields:    
    3. Region-dependent bone loss in the lumbar spine following femoral fracture in mice. Bone. 2020 Nov; 140:115555. Ely EV, Osipov B, Emami AJ, Christiansen BA. PMID: 32736144.
      View in: PubMed   Mentions:    Fields:    
    4. LPS-Induced Inflammation Prior to Injury Exacerbates the Development of Post-Traumatic Osteoarthritis in Mice. J Bone Miner Res. 2020 Jun 21. Mendez ME, Sebastian A, Murugesh DK, Hum NR, McCool JL, Hsia AW, Christiansen BA, Loots GG. PMID: 32564401.
      View in: PubMed   Mentions: 1     Fields:    
    5. Thermoresponsive, hollow, degradable core-shell nanoparticles for intra-articular delivery of anti-inflammatory peptide. J Control Release. 2020 Jul 10; 323:47-58. Deloney M, Smart K, Christiansen BA, Panitch A. PMID: 32278830.
      View in: PubMed   Mentions:    Fields:    
    6. Global Gene Expression Analysis Identifies Age-Related Differences in Knee Joint Transcriptome during the Development of Post-Traumatic Osteoarthritis in Mice. Int J Mol Sci. 2020 Jan 06; 21(1). Sebastian A, Murugesh DK, Mendez ME, Hum NR, Rios-Arce ND, McCool JL, Christiansen BA, Loots GG. PMID: 31935848.
      View in: PubMed   Mentions: 1     Fields:    
    7. Acute Changes in NADPH Oxidase 4 in Early Post-Traumatic Osteoarthritis. J Orthop Res. 2019 11; 37(11):2429-2436. Wegner AM, Campos NR, Robbins MA, Haddad AF, Cunningham HC, Yik JHN, Christiansen BA, Haudenschild DR. PMID: 31304988.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. InternalBrace has biomechanical properties comparable to suture button but less rigid than screw in ligamentous lisfranc model. J Orthop. 2020 Jan-Feb; 17:7-12. Hopkins J, Nguyen K, Heyrani N, Shelton T, Kreulen C, Garcia-Nolen T, Christiansen BA, Giza E. PMID: 31879465.
      View in: PubMed   Mentions:
    9. The importance of performing knee surgery in rats. Osteoarthritis Cartilage. 2019 08; 27(8):1107-1108. Christiansen BA. PMID: 31034922.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    10. Systemic Bone Loss After Fracture. Clin Rev Bone Miner Metab. 2018 Dec; 16(4):116-130. Osipov B, Emami AJ, Christiansen BA. PMID: 31363348.
      View in: PubMed   Mentions:
    11. Age Dependence of Systemic Bone Loss and Recovery Following Femur Fracture in Mice. J Bone Miner Res. 2019 01; 34(1):157-170. Emami AJ, Toupadakis CA, Telek SM, Fyhrie DP, Yellowley CE, Christiansen BA. PMID: 30189111.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    12. Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression. Int J Mol Sci. 2018 Sep 07; 19(9). Sebastian A, Chang JC, Mendez ME, Murugesh DK, Hatsell S, Economides AN, Christiansen BA, Loots GG. PMID: 30205482.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Age-dependent bone loss and recovery during hindlimb unloading and subsequent reloading in rats. BMC Musculoskelet Disord. 2018 Jul 18; 19(1):223. Cunningham HC, West DWD, Baehr LM, Tarke FD, Baar K, Bodine SC, Christiansen BA. PMID: 30021585.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    14. Incident fracture is associated with a period of accelerated loss of hip BMD: the Study of Osteoporotic Fractures. Osteoporos Int. 2018 Oct; 29(10):2201-2209. Christiansen BA, Harrison SL, Fink HA, Lane NE. PMID: 29992510.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    15. Comparison of knee injury threshold during tibial compression based on limb orientation in mice. J Biomech. 2018 06 06; 74:220-224. Hsia AW, Tarke FD, Shelton TJ, Tjandra PM, Christiansen BA. PMID: 29678417.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    16. SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury. J Bone Miner Res. 2018 06; 33(6):1105-1113. Chang JC, Christiansen BA, Murugesh DK, Sebastian A, Hum NR, Collette NM, Hatsell S, Economides AN, Blanchette CD, Loots GG. PMID: 29377313.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. Osteophytes and fracture calluses share developmental milestones and are diminished by unloading. J Orthop Res. 2018 02; 36(2):699-710. Hsia AW, Emami AJ, Tarke FD, Cunningham HC, Tjandra PM, Wong A, Christiansen BA, Collette NM. PMID: 29058776.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    18. Bone adaptation to mechanical loading in a mouse model of reduced peripheral sensory nerve function. PLoS One. 2017; 12(10):e0187354. Heffner MA, Genetos DC, Christiansen BA. PMID: 29088267.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    19. Achieving interfragmentary compression without special drilling technique or screw design. J Orthop Res. 2018 04; 36(4):1099-1105. Eastman J, Deafenbaugh B, Christiansen B, Garcia-Nolen T, Lee M. PMID: 28885726.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. The mechanism of thoracolumbar burst fracture may be related to the basivertebral foramen. Spine J. 2018 03; 18(3):472-481. Zhang X, Li S, Zhao X, Christiansen BA, Chen J, Fan S, Zhao F. PMID: 28823938.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Trabecular Microstructure and Damage Affect Cement Leakage From the Basivertebral Foramen During Vertebral Augmentation. Spine (Phila Pa 1976). 2017 Aug 15; 42(16):E939-E948. Li S, Wang C, Shan Z, Liu J, Yu T, Zhang X, Fan S, Christiansen BA, Ding W, Zhao F. PMID: 28098744.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Corrigendum to "Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis" [J. Autoimmun. 73C (2016) 73-84]. J Autoimmun. 2017 11; 84:132. Wu DJ, Gu R, Sarin R, Zavodovskaya R, Chen CP, Christiansen BA, Zarbalis KS, Adamopoulos IE. PMID: 28757133.
      View in: PubMed   Mentions:    Fields:    
    23. Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis. J Autoimmun. 2016 09; 73:73-84. Wu DJ, Gu R, Sarin R, Zavodovskaya R, Chen CP, Christiansen BA, Adamopoulos IE. PMID: 27330028.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    24. Effect of micro-computed tomography voxel size and segmentation method on trabecular bone microstructure measures in mice. Bone Rep. 2016 Dec; 5:136-40. Christiansen BA. PMID: 27430011.
      View in: PubMed   Mentions:
    25. Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis. J Orthop Res. 2017 03; 35(3):474-485. Chang JC, Sebastian A, Murugesh DK, Hatsell S, Economides AN, Christiansen BA, Loots GG. PMID: 27088242.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    26. Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells. Bone. 2016 07; 88:20-30. Collette NM, Yee CS, Hum NR, Murugesh DK, Christiansen BA, Xie L, Economides AN, Manilay JO, Robling AG, Loots GG. PMID: 27102547.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    27. Osteophyte formation after ACL rupture in mice is associated with joint restabilization and loss of range of motion. J Orthop Res. 2017 03; 35(3):466-473. Hsia AW, Anderson MJ, Heffner MA, Lagmay EP, Zavodovskaya R, Christiansen BA. PMID: 27031945.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    28. Contribution of mechanical unloading to trabecular bone loss following non-invasive knee injury in mice. J Orthop Res. 2016 10; 34(10):1680-1687. Anderson MJ, Diko S, Baehr LM, Baar K, Bodine SC, Christiansen BA. PMID: 26826014.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    29. Erratum: Response to the Letter to the Editor for "Management of Osteoarthritis with Avocado/Soybean Unsaponifiables". Cartilage. 2016 Jan; 7(1):114-5. Christiansen BA, Bhatti S, Goudarzi R, Emami S. PMID: 26958324.
      View in: PubMed   Mentions:    Fields:    
    30. SOST Inhibits Prostate Cancer Invasion. PLoS One. 2015; 10(11):e0142058. Hudson BD, Hum NR, Thomas CB, Kohlgruber A, Sebastian A, Collette NM, Coleman MA, Christiansen BA, Loots GG. PMID: 26545120.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    31. BMP-7 and Bone Regeneration: Evaluation of Dose-Response in a Rodent Segmental Defect Model. J Orthop Trauma. 2015 Sep; 29(9):e336-41. Williams JC, Maitra S, Anderson MJ, Christiansen BA, Reddi AH, Lee MA. PMID: 26295737.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    32. Non-invasive mouse models of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2015 Oct; 23(10):1627-38. Christiansen BA, Guilak F, Lockwood KA, Olson SA, Pitsillides AA, Sandell LJ, Silva MJ, van der Meulen MC, Haudenschild DR. PMID: 26003950.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    33. Bone Material Properties and Skeletal Fragility. Calcif Tissue Int. 2015 Sep; 97(3):213-28. Fyhrie DP, Christiansen BA. PMID: 25939648.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    34. Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice. Arthritis Res Ther. 2015 Feb 16; 17:30. Khorasani MS, Diko S, Hsia AW, Anderson MJ, Genetos DC, Haudenschild DR, Christiansen BA. PMID: 25888819.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    35. Trabecular bone loss at a distant skeletal site following noninvasive knee injury in mice. J Biomech Eng. 2015 Jan; 137(1). Christiansen BA, Emami AJ, Fyhrie DP, Satkunananthan PB, Hardisty MR. PMID: 25322065.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    36. Management of Osteoarthritis with Avocado/Soybean Unsaponifiables. Cartilage. 2015 Jan; 6(1):30-44. Christiansen BA, Bhatti S, Goudarzi R, Emami S. PMID: 25621100.
      View in: PubMed   Mentions: 15     Fields:    
    37. Closed Joint ACL Disruption Murine Model of PTA. . 2015 Jan 1; 75-85. Blaine A. Christiansen, Jasper H. N. Yik, Dominik R. Haudenschild. .
      View in: Publisher Site   Mentions:
    38. Trabecular bone: light as a feather, stiff as a board. J Biomech Eng. 2015 Jan; 137(1). Nazarian A, Christiansen BA. PMID: 25408309.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    39. In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2014 Oct; 22(10):1461-9. Satkunananthan PB, Anderson MJ, De Jesus NM, Haudenschild DR, Ripplinger CM, Christiansen BA. PMID: 25278057.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    40. Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines. Arthritis Rheumatol. 2014 Jun; 66(6):1537-46. Yik JH, Hu Z, Kumari R, Christiansen BA, Haudenschild DR. PMID: 24470357.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    41. The effect of noggin interference in a rabbit posterolateral spinal fusion model. Eur Spine J. 2014 Nov; 23(11):2385-92. Klineberg E, Haudenschild DR, Snow KD, Garitty S, Christiansen BA, Acharya C, Maitra S, Gupta MC. PMID: 24740279.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    42. Altered bone development in a mouse model of peripheral sensory nerve inactivation. J Musculoskelet Neuronal Interact. 2014 Mar; 14(1):1-9. Heffner MA, Anderson MJ, Yeh GC, Genetos DC, Christiansen BA. PMID: 24583535.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    43. Remineralized bone matrix as a scaffold for bone tissue engineering. J Biomed Mater Res A. 2014 Dec; 102(12):4480-90. Soicher MA, Christiansen BA, Stover SM, Leach JK, Yellowley CE, Griffiths LG, Fyhrie DP. PMID: 24616346.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    44. Locking versus nonlocking construct in an osteoporotic, segmental fibula defect model. Orthopedics. 2013 Oct 01; 36(10):e1262-8. Lo EY, Tseng SS, Christiansen BA, Lee MA, Yoo BJ. PMID: 24093701.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    45. Comparison of loading rate-dependent injury modes in a murine model of post-traumatic osteoarthritis. J Orthop Res. 2014 Jan; 32(1):79-88. Lockwood KA, Chu BT, Anderson MJ, Haudenschild DR, Christiansen BA. PMID: 24019199.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    46. Assessment of Bone Mass and Microarchitecture in Rodents. . 2013 Jul 19; 59-68. Blaine A. Christiansen. .
      View in: Publisher Site   Mentions:
    47. Remineralization of demineralized bone matrix (DBM) via alternating solution immersion (ASI). J Mech Behav Biomed Mater. 2013 Oct; 26:109-18. Soicher MA, Christiansen BA, Stover SM, Leach JK, Fyhrie DP. PMID: 23759125.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    48. Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass. J Bone Miner Res. 2013 Apr; 28(4):875-85. Ellman R, Spatz J, Cloutier A, Palme R, Christiansen BA, Bouxsein ML. PMID: 23165526.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    49. Cartilage oligomeric matrix protein enhances osteogenesis by directly binding and activating bone morphogenetic protein-2. Bone. 2013 Jul; 55(1):23-35. Ishida K, Acharya C, Christiansen BA, Yik JH, DiCesare PE, Haudenschild DR. PMID: 23528838.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    50. Mechanical and morphological properties of trabecular bone samples obtained from third metacarpal bones of cadavers of horses with a bone fragility syndrome and horses unaffected by that syndrome. Am J Vet Res. 2012 Nov; 73(11):1742-51. Symons JE, Entwistle RC, Arens AM, Garcia TC, Christiansen BA, Fyhrie DP, Stover SM. PMID: 23106459.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    51. Long-term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling, alters fracture repair. J Orthop Res. 2012 Nov; 30(11):1853-9. Toupadakis CA, Wong A, Genetos DC, Chung DJ, Murugesh D, Anderson MJ, Loots GG, Christiansen BA, Kapatkin AS, Yellowley CE. PMID: 22592891.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    52. Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2012 Jul; 20(7):773-82. Christiansen BA, Anderson MJ, Lee CA, Williams JC, Yik JH, Haudenschild DR. PMID: 22531459.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    53. QCT measures of bone strength at the thoracic and lumbar spine: the Framingham Study. J Bone Miner Res. 2012 Mar; 27(3):654-63. Samelson EJ, Christiansen BA, Demissie S, Broe KE, Louie-Gao Q, Cupples LA, Roberts BJ, Manoharam R, D'Agostino J, Lang T, Kiel DP, Bouxsein ML. PMID: 22143959.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    54. Mechanical contributions of the cortical and trabecular compartments contribute to differences in age-related changes in vertebral body strength in men and women assessed by QCT-based finite element analysis. J Bone Miner Res. 2011 May; 26(5):974-83. Christiansen BA, Kopperdahl DL, Kiel DP, Keaveny TM, Bouxsein ML. PMID: 21542000.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    55. Biomechanics of vertebral fractures and the vertebral fracture cascade. Curr Osteoporos Rep. 2010 Dec; 8(4):198-204. Christiansen BA, Bouxsein ML. PMID: 20838942.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    56. A biomechanical model for estimating loads on thoracic and lumbar vertebrae. Clin Biomech (Bristol, Avon). 2010 Nov; 25(9):853-8. Iyer S, Christiansen BA, Roberts BJ, Valentine MJ, Manoharan RK, Bouxsein ML. PMID: 20655634.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    57. Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res. 2010 Jul; 25(7):1468-86. Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ, Müller R. PMID: 20533309.
      View in: PubMed   Mentions: 956     Fields:    Translation:Animals
    58. Reliability of vertebral fracture assessment using multidetector CT lateral scout views: the Framingham Osteoporosis Study. Osteoporos Int. 2011 Apr; 22(4):1123-31. Samelson EJ, Christiansen BA, Demissie S, Broe KE, Zhou Y, Meng CA, Yu W, Cheng X, O'Donnell CJ, Hoffmann U, Genant HK, Kiel DP, Bouxsein ML. PMID: 20495902.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    59. Constrained tibial vibration does not produce an anabolic bone response in adult mice. Bone. 2009 Oct; 45(4):750-9. Christiansen BA, Kotiya AA, Silva MJ. PMID: 19576309.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    60. A New Biomechanical Model for Estimating Vertebral Loading in the Thoracic Spine. . 2009 Jun 17; 1129-1130. Sravisht Iyer, Blaine A. Christiansen, Benjamin J. Roberts, Michael J. Valentine, Rajaram Manoharan, Mary L. Bouxsein. .
      View in: Publisher Site   Mentions:
    61. Whole-body vibration and weight loss: truth or consequence? Int J Obes (Lond). 2009 Mar; 33(3):384; author reply 382-3. Christiansen BA. PMID: 19153586.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    62. Constrained tibial vibration in mice: a method for studying the effects of vibrational loading of bone. J Biomech Eng. 2008 Aug; 130(4):044502. Christiansen BA, Bayly PV, Silva MJ. PMID: 18601464.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    63. Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice. Am J Pathol. 2008 Apr; 172(4):868-81. Ramanadham S, Yarasheski KE, Silva MJ, Wohltmann M, Novack DV, Christiansen B, Tu X, Zhang S, Lei X, Turk J. PMID: 18349124.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    64. The effect of varying magnitudes of whole-body vibration on several skeletal sites in mice. Ann Biomed Eng. 2006 Jul; 34(7):1149-56. Christiansen BA, Silva MJ. PMID: 16786394.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells