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Blaine A Christiansen, PhD; MS

Title(s)Associate Professor, Orthopaedic Surgery
SchoolUniversity of California, Davis
Phone916-734-3974
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    Collapse Biography 
    Collapse Education and Training
    University of Nebraska, Lincoln, NEBS12/2001Biological Systems Engineering
    Washington University, St. Louis, MOMS05/2004Biomedical Engineering
    Washington University, St. Louis, MOPh.D.12/2007Biomedical Engineering
    Beth Israel Deaconess Medical Center, Boston, MAPostdoctoral Fellowship02/2010Orthopaedic Research
    Collapse Awards and Honors
    American Society of Mechanical Engineers 2005Summer Bioengineering Conference, 1st Place - Student Paper Competition
    United States Bone and Joint Decade 2010  - 2011Young Investigators Initiative
    American Society for Bone and Mineral Research 2010Young Investigator Award
    International Bone and Mineral Society/American Society for Bone and Mineral Research2011Harold M. Frost Young Investigator Award
    American Society for Bone and Mineral Research2014Junior Faculty Osteoporosis Research Award
    International Bone and Mineral Society2014Alice L. Jee Memorial Young Investigator Award

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of Systemic Bone Loss Following Femur Fracture in Mice
    NIH/NIAMS R01AR071459Sep 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    The role of the inflammatory response in bone and cartilage changes following non
    NIH/NIAMS K01AR062603Sep 10, 2012 - Aug 31, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Sebastian A, Murugesh DK, Mendez ME, Hum NR, Rios-Arce ND, McCool JL, Christiansen BA, Loots GG. Global Gene Expression Analysis Identifies Age-Related Differences in Knee Joint Transcriptome during the Development of Post-Traumatic Osteoarthritis in Mice. Int J Mol Sci. 2020 Jan 06; 21(1). PMID: 31935848.
      View in: PubMed
    2. Wegner AM, Campos NR, Robbins MA, Haddad AF, Cunningham HC, Yik JHN, Christiansen BA, Haudenschild DR. Acute Changes in NADPH Oxidase 4 in Early Post-Traumatic Osteoarthritis. J Orthop Res. 2019 11; 37(11):2429-2436. PMID: 31304988.
      View in: PubMed
    3. Hopkins J, Nguyen K, Heyrani N, Shelton T, Kreulen C, Garcia-Nolen T, Christiansen BA, Giza E. InternalBrace has biomechanical properties comparable to suture button but less rigid than screw in ligamentous lisfranc model. J Orthop. 2020 Jan-Feb; 17:7-12. PMID: 31879465.
      View in: PubMed
    4. Christiansen BA. The importance of performing knee surgery in rats. Osteoarthritis Cartilage. 2019 08; 27(8):1107-1108. PMID: 31034922.
      View in: PubMed
    5. Osipov B, Emami AJ, Christiansen BA. Systemic Bone Loss After Fracture. Clin Rev Bone Miner Metab. 2018 Dec; 16(4):116-130. PMID: 31363348.
      View in: PubMed
    6. Emami AJ, Toupadakis CA, Telek SM, Fyhrie DP, Yellowley CE, Christiansen BA. Age Dependence of Systemic Bone Loss and Recovery Following Femur Fracture in Mice. J Bone Miner Res. 2019 01; 34(1):157-170. PMID: 30189111.
      View in: PubMed
    7. Sebastian A, Chang JC, Mendez ME, Murugesh DK, Hatsell S, Economides AN, Christiansen BA, Loots GG. Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression. Int J Mol Sci. 2018 Sep 07; 19(9). PMID: 30205482.
      View in: PubMed
    8. Cunningham HC, West DWD, Baehr LM, Tarke FD, Baar K, Bodine SC, Christiansen BA. Age-dependent bone loss and recovery during hindlimb unloading and subsequent reloading in rats. BMC Musculoskelet Disord. 2018 Jul 18; 19(1):223. PMID: 30021585.
      View in: PubMed
    9. Christiansen BA, Harrison SL, Fink HA, Lane NE. Incident fracture is associated with a period of accelerated loss of hip BMD: the Study of Osteoporotic Fractures. Osteoporos Int. 2018 Oct; 29(10):2201-2209. PMID: 29992510.
      View in: PubMed
    10. Hsia AW, Tarke FD, Shelton TJ, Tjandra PM, Christiansen BA. Comparison of knee injury threshold during tibial compression based on limb orientation in mice. J Biomech. 2018 06 06; 74:220-224. PMID: 29678417.
      View in: PubMed
    11. Chang JC, Christiansen BA, Murugesh DK, Sebastian A, Hum NR, Collette NM, Hatsell S, Economides AN, Blanchette CD, Loots GG. SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury. J Bone Miner Res. 2018 06; 33(6):1105-1113. PMID: 29377313.
      View in: PubMed
    12. Hsia AW, Emami AJ, Tarke FD, Cunningham HC, Tjandra PM, Wong A, Christiansen BA, Collette NM. Osteophytes and fracture calluses share developmental milestones and are diminished by unloading. J Orthop Res. 2018 02; 36(2):699-710. PMID: 29058776.
      View in: PubMed
    13. Heffner MA, Genetos DC, Christiansen BA. Bone adaptation to mechanical loading in a mouse model of reduced peripheral sensory nerve function. PLoS One. 2017; 12(10):e0187354. PMID: 29088267.
      View in: PubMed
    14. Eastman J, Deafenbaugh B, Christiansen B, Garcia-Nolen T, Lee M. Achieving interfragmentary compression without special drilling technique or screw design. J Orthop Res. 2018 04; 36(4):1099-1105. PMID: 28885726.
      View in: PubMed
    15. Zhang X, Li S, Zhao X, Christiansen BA, Chen J, Fan S, Zhao F. The mechanism of thoracolumbar burst fracture may be related to the basivertebral foramen. Spine J. 2018 03; 18(3):472-481. PMID: 28823938.
      View in: PubMed
    16. Li S, Wang C, Shan Z, Liu J, Yu T, Zhang X, Fan S, Christiansen BA, Ding W, Zhao F. Trabecular Microstructure and Damage Affect Cement Leakage From the Basivertebral Foramen During Vertebral Augmentation. Spine (Phila Pa 1976). 2017 Aug 15; 42(16):E939-E948. PMID: 28098744.
      View in: PubMed
    17. Wu DJ, Gu R, Sarin R, Zavodovskaya R, Chen CP, Christiansen BA, Zarbalis KS, Adamopoulos IE. Corrigendum to "Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis" [J. Autoimmun. 73C (2016) 73-84]. J Autoimmun. 2017 11; 84:132. PMID: 28757133.
      View in: PubMed
    18. Wu DJ, Gu R, Sarin R, Zavodovskaya R, Chen CP, Christiansen BA, Adamopoulos IE. Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis. J Autoimmun. 2016 09; 73:73-84. PMID: 27330028.
      View in: PubMed
    19. Christiansen BA. Effect of micro-computed tomography voxel size and segmentation method on trabecular bone microstructure measures in mice. Bone Rep. 2016 Dec; 5:136-40. PMID: 27430011.
      View in: PubMed
    20. Chang JC, Sebastian A, Murugesh DK, Hatsell S, Economides AN, Christiansen BA, Loots GG. Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis. J Orthop Res. 2017 03; 35(3):474-485. PMID: 27088242.
      View in: PubMed
    21. Collette NM, Yee CS, Hum NR, Murugesh DK, Christiansen BA, Xie L, Economides AN, Manilay JO, Robling AG, Loots GG. Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells. Bone. 2016 07; 88:20-30. PMID: 27102547.
      View in: PubMed
    22. Hsia AW, Anderson MJ, Heffner MA, Lagmay EP, Zavodovskaya R, Christiansen BA. Osteophyte formation after ACL rupture in mice is associated with joint restabilization and loss of range of motion. J Orthop Res. 2017 03; 35(3):466-473. PMID: 27031945.
      View in: PubMed
    23. Anderson MJ, Diko S, Baehr LM, Baar K, Bodine SC, Christiansen BA. Contribution of mechanical unloading to trabecular bone loss following non-invasive knee injury in mice. J Orthop Res. 2016 10; 34(10):1680-1687. PMID: 26826014.
      View in: PubMed
    24. Christiansen BA, Bhatti S, Goudarzi R, Emami S. Erratum: Response to the Letter to the Editor for "Management of Osteoarthritis with Avocado/Soybean Unsaponifiables". Cartilage. 2016 Jan; 7(1):114-5. PMID: 26958324.
      View in: PubMed
    25. Hudson BD, Hum NR, Thomas CB, Kohlgruber A, Sebastian A, Collette NM, Coleman MA, Christiansen BA, Loots GG. SOST Inhibits Prostate Cancer Invasion. PLoS One. 2015; 10(11):e0142058. PMID: 26545120.
      View in: PubMed
    26. Williams JC, Maitra S, Anderson MJ, Christiansen BA, Reddi AH, Lee MA. BMP-7 and Bone Regeneration: Evaluation of Dose-Response in a Rodent Segmental Defect Model. J Orthop Trauma. 2015 Sep; 29(9):e336-41. PMID: 26295737.
      View in: PubMed
    27. Christiansen BA, Guilak F, Lockwood KA, Olson SA, Pitsillides AA, Sandell LJ, Silva MJ, van der Meulen MC, Haudenschild DR. Non-invasive mouse models of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2015 Oct; 23(10):1627-38. PMID: 26003950.
      View in: PubMed
    28. Fyhrie DP, Christiansen BA. Bone Material Properties and Skeletal Fragility. Calcif Tissue Int. 2015 Sep; 97(3):213-28. PMID: 25939648.
      View in: PubMed
    29. Khorasani MS, Diko S, Hsia AW, Anderson MJ, Genetos DC, Haudenschild DR, Christiansen BA. Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice. Arthritis Res Ther. 2015 Feb 16; 17:30. PMID: 25888819.
      View in: PubMed
    30. Christiansen BA, Emami AJ, Fyhrie DP, Satkunananthan PB, Hardisty MR. Trabecular bone loss at a distant skeletal site following noninvasive knee injury in mice. J Biomech Eng. 2015 Jan; 137(1). PMID: 25322065.
      View in: PubMed
    31. Christiansen BA, Bhatti S, Goudarzi R, Emami S. Management of Osteoarthritis with Avocado/Soybean Unsaponifiables. Cartilage. 2015 Jan; 6(1):30-44. PMID: 25621100.
      View in: PubMed
    32. Blaine A. Christiansen, Jasper H. N. Yik, Dominik R. Haudenschild. Closed Joint ACL Disruption Murine Model of PTA. 2015 Jan 1; 75-85.
      View in: Publisher Site
    33. Nazarian A, Christiansen BA. Trabecular bone: light as a feather, stiff as a board. J Biomech Eng. 2015 Jan; 137(1). PMID: 25408309.
      View in: PubMed
    34. Satkunananthan PB, Anderson MJ, De Jesus NM, Haudenschild DR, Ripplinger CM, Christiansen BA. In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2014 Oct; 22(10):1461-9. PMID: 25278057.
      View in: PubMed
    35. Yik JH, Hu Z, Kumari R, Christiansen BA, Haudenschild DR. Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines. Arthritis Rheumatol. 2014 Jun; 66(6):1537-46. PMID: 24470357.
      View in: PubMed
    36. Klineberg E, Haudenschild DR, Snow KD, Garitty S, Christiansen BA, Acharya C, Maitra S, Gupta MC. The effect of noggin interference in a rabbit posterolateral spinal fusion model. Eur Spine J. 2014 Nov; 23(11):2385-92. PMID: 24740279.
      View in: PubMed
    37. Heffner MA, Anderson MJ, Yeh GC, Genetos DC, Christiansen BA. Altered bone development in a mouse model of peripheral sensory nerve inactivation. J Musculoskelet Neuronal Interact. 2014 Mar; 14(1):1-9. PMID: 24583535.
      View in: PubMed
    38. Soicher MA, Christiansen BA, Stover SM, Leach JK, Yellowley CE, Griffiths LG, Fyhrie DP. Remineralized bone matrix as a scaffold for bone tissue engineering. J Biomed Mater Res A. 2014 Dec; 102(12):4480-90. PMID: 24616346.
      View in: PubMed
    39. Lo EY, Tseng SS, Christiansen BA, Lee MA, Yoo BJ. Locking versus nonlocking construct in an osteoporotic, segmental fibula defect model. Orthopedics. 2013 Oct 01; 36(10):e1262-8. PMID: 24093701.
      View in: PubMed
    40. Lockwood KA, Chu BT, Anderson MJ, Haudenschild DR, Christiansen BA. Comparison of loading rate-dependent injury modes in a murine model of post-traumatic osteoarthritis. J Orthop Res. 2014 Jan; 32(1):79-88. PMID: 24019199.
      View in: PubMed
    41. Blaine A. Christiansen. Assessment of Bone Mass and Microarchitecture in Rodents. 2013 Jul 19; 59-68.
      View in: Publisher Site
    42. Soicher MA, Christiansen BA, Stover SM, Leach JK, Fyhrie DP. Remineralization of demineralized bone matrix (DBM) via alternating solution immersion (ASI). J Mech Behav Biomed Mater. 2013 Oct; 26:109-18. PMID: 23759125.
      View in: PubMed
    43. Ellman R, Spatz J, Cloutier A, Palme R, Christiansen BA, Bouxsein ML. Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass. J Bone Miner Res. 2013 Apr; 28(4):875-85. PMID: 23165526.
      View in: PubMed
    44. Ishida K, Acharya C, Christiansen BA, Yik JH, DiCesare PE, Haudenschild DR. Cartilage oligomeric matrix protein enhances osteogenesis by directly binding and activating bone morphogenetic protein-2. Bone. 2013 Jul; 55(1):23-35. PMID: 23528838.
      View in: PubMed
    45. Symons JE, Entwistle RC, Arens AM, Garcia TC, Christiansen BA, Fyhrie DP, Stover SM. Mechanical and morphological properties of trabecular bone samples obtained from third metacarpal bones of cadavers of horses with a bone fragility syndrome and horses unaffected by that syndrome. Am J Vet Res. 2012 Nov; 73(11):1742-51. PMID: 23106459.
      View in: PubMed
    46. Toupadakis CA, Wong A, Genetos DC, Chung DJ, Murugesh D, Anderson MJ, Loots GG, Christiansen BA, Kapatkin AS, Yellowley CE. Long-term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling, alters fracture repair. J Orthop Res. 2012 Nov; 30(11):1853-9. PMID: 22592891.
      View in: PubMed
    47. Christiansen BA, Anderson MJ, Lee CA, Williams JC, Yik JH, Haudenschild DR. Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2012 Jul; 20(7):773-82. PMID: 22531459.
      View in: PubMed
    48. Samelson EJ, Christiansen BA, Demissie S, Broe KE, Louie-Gao Q, Cupples LA, Roberts BJ, Manoharam R, D'Agostino J, Lang T, Kiel DP, Bouxsein ML. QCT measures of bone strength at the thoracic and lumbar spine: the Framingham Study. J Bone Miner Res. 2012 Mar; 27(3):654-63. PMID: 22143959.
      View in: PubMed
    49. Christiansen BA, Kopperdahl DL, Kiel DP, Keaveny TM, Bouxsein ML. Mechanical contributions of the cortical and trabecular compartments contribute to differences in age-related changes in vertebral body strength in men and women assessed by QCT-based finite element analysis. J Bone Miner Res. 2011 May; 26(5):974-83. PMID: 21542000.
      View in: PubMed
    50. Christiansen BA, Bouxsein ML. Biomechanics of vertebral fractures and the vertebral fracture cascade. Curr Osteoporos Rep. 2010 Dec; 8(4):198-204. PMID: 20838942.
      View in: PubMed
    51. Iyer S, Christiansen BA, Roberts BJ, Valentine MJ, Manoharan RK, Bouxsein ML. A biomechanical model for estimating loads on thoracic and lumbar vertebrae. Clin Biomech (Bristol, Avon). 2010 Nov; 25(9):853-8. PMID: 20655634.
      View in: PubMed
    52. Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ, Müller R. Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res. 2010 Jul; 25(7):1468-86. PMID: 20533309.
      View in: PubMed
    53. Samelson EJ, Christiansen BA, Demissie S, Broe KE, Zhou Y, Meng CA, Yu W, Cheng X, O'Donnell CJ, Hoffmann U, Genant HK, Kiel DP, Bouxsein ML. Reliability of vertebral fracture assessment using multidetector CT lateral scout views: the Framingham Osteoporosis Study. Osteoporos Int. 2011 Apr; 22(4):1123-31. PMID: 20495902.
      View in: PubMed
    54. Christiansen BA, Kotiya AA, Silva MJ. Constrained tibial vibration does not produce an anabolic bone response in adult mice. Bone. 2009 Oct; 45(4):750-9. PMID: 19576309.
      View in: PubMed
    55. Sravisht Iyer, Blaine A. Christiansen, Benjamin J. Roberts, Michael J. Valentine, Rajaram Manoharan, Mary L. Bouxsein. A New Biomechanical Model for Estimating Vertebral Loading in the Thoracic Spine. 2009 Jun 17; 1129-1130.
      View in: Publisher Site
    56. Christiansen BA. Whole-body vibration and weight loss: truth or consequence? Int J Obes (Lond). 2009 Mar; 33(3):384; author reply 382-3. PMID: 19153586.
      View in: PubMed
    57. Christiansen BA, Bayly PV, Silva MJ. Constrained tibial vibration in mice: a method for studying the effects of vibrational loading of bone. J Biomech Eng. 2008 Aug; 130(4):044502. PMID: 18601464.
      View in: PubMed
    58. Ramanadham S, Yarasheski KE, Silva MJ, Wohltmann M, Novack DV, Christiansen B, Tu X, Zhang S, Lei X, Turk J. Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice. Am J Pathol. 2008 Apr; 172(4):868-81. PMID: 18349124.
      View in: PubMed
    59. Christiansen BA, Silva MJ. The effect of varying magnitudes of whole-body vibration on several skeletal sites in mice. Ann Biomed Eng. 2006 Jul; 34(7):1149-56. PMID: 16786394.
      View in: PubMed