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Lucas Robert Smith

Title(s)Assistant Professor, Physical Medicine and Rehabilitation
SchoolUniversity of California, Davis
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    Collapse Research 
    Collapse Research Activities and Funding
    The role of collagen organization in determination of fibrotic muscle function and regeneration
    NIH/NIAMS R00AR067867Sep 1, 2018 - Jul 31, 2021
    Role: Principal Investigator
    The role of collagen organization in determination of fibrotic muscle function and regeneration
    NIH/NIAMS K99AR067867Jun 1, 2016 - May 31, 2018
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Smith LR, Pichika R, Meza RC, Gillies AR, Baliki MN, Chambers HG, Lieber RL. Contribution of extracellular matrix components to the stiffness of skeletal muscle contractures in patients with cerebral palsy. Connect Tissue Res. 2019 Nov 28; 1-12. PMID: 31779492.
      View in: PubMed
    2. Smith LR, Meyer GA. Skeletal muscle explants: ex-vivo models to study cellular behavior in a complex tissue environment. Connect Tissue Res. 2019 Sep 06; 1-14. PMID: 31492079.
      View in: PubMed
    3. Barton ER, Pham J, Brisson BK, Park S, Smith LR, Liu M, Tian Z, Hammers DW, Vassilakos G, Sweeney HL. Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin. Muscle Nerve. 2019 10; 60(4):464-473. PMID: 31323135.
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    4. Xia Y, Pfeifer CR, Zhu K, Irianto J, Liu D, Pannell K, Chen EJ, Dooling LJ, Tobin MP, Wang M, Ivanovska IL, Smith LR, Greenberg RA, Discher DE. Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. J Cell Biol. 2019 Aug 05; 218(8):2545-2563. PMID: 31239284.
      View in: PubMed
    5. Smith LR, Irianto J, Xia Y, Pfeifer CR, Discher DE. Constricted migration modulates stem cell differentiation. Mol Biol Cell. 2019 07 22; 30(16):1985-1999. PMID: 31188712.
      View in: PubMed
    6. Smith LR, Barton ER. Regulation of fibrosis in muscular dystrophy. Matrix Biol. 2018 08; 68-69:602-615. PMID: 29408413.
      View in: PubMed
    7. Ban E, Franklin JM, Nam S, Smith LR, Wang H, Wells RG, Chaudhuri O, Liphardt JT, Shenoy VB. Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces. Biophys J. 2018 01 23; 114(2):450-461. PMID: 29401442.
      View in: PubMed
    8. Smith LR, Cho S, Discher DE. Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics. Physiology (Bethesda). 2018 Jan 01; 33(1):16-25. PMID: 29212889.
      View in: PubMed
    9. Sandoz MA, Wages M, Wooten KJ, Clendening SL, Smith LR, Mulhearn B, Smith PN. Surface water mitigates the anti-metamorphic effects of elevated perchlorate concentrations in New Mexico spadefoot toad larvae (Spea multiplicata). Environ Sci Pollut Res Int. 2017 Jul; 24(21):17839-17844. PMID: 28608158.
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    10. Smith LR, Hammers DW, Sweeney HL, Barton ER. Increased collagen cross-linking is a signature of dystrophin-deficient muscle. Muscle Nerve. 2016 06; 54(1):71-8. PMID: 26616495.
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    11. Philippou A, Minozzo FC, Spinazzola JM, Smith LR, Lei H, Rassier DE, Barton ER. Masticatory muscles of mouse do not undergo atrophy in space. FASEB J. 2015 Jul; 29(7):2769-79. PMID: 25795455.
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    12. Smith LR, Barton ER. SMASH - semi-automatic muscle analysis using segmentation of histology: a MATLAB application. Skelet Muscle. 2014; 4:21. PMID: 25937889.
      View in: PubMed
    13. Ceco E, Bogdanovich S, Gardner B, Miller T, DeJesus A, Earley JU, Hadhazy M, Smith LR, Barton ER, Molkentin JD, McNally EM. Targeting latent TGFß release in muscular dystrophy. Sci Transl Med. 2014 Oct 22; 6(259):259ra144. PMID: 25338755.
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    14. Smith LR. Influencing the secretion of myogenic factors from mesenchymal stem cells. Stem Cell Res Ther. 2014 Aug 13; 5(4):96. PMID: 25157834.
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    15. Smith LR, Barton ER. Collagen content does not alter the passive mechanical properties of fibrotic skeletal muscle in mdx mice. Am J Physiol Cell Physiol. 2014 May 15; 306(10):C889-98. PMID: 24598364.
      View in: PubMed
    16. Lei H, Leong D, Smith LR, Barton ER. Matrix metalloproteinase 13 is a new contributor to skeletal muscle regeneration and critical for myoblast migration. Am J Physiol Cell Physiol. 2013 Sep; 305(5):C529-38. PMID: 23761625.
      View in: PubMed
    17. Smith LR, Chambers HG, Lieber RL. Reduced satellite cell population may lead to contractures in children with cerebral palsy. Dev Med Child Neurol. 2013 Mar; 55(3):264-70. PMID: 23210987.
      View in: PubMed
    18. Smith LR, Meyer G, Lieber RL. Systems analysis of biological networks in skeletal muscle function. Wiley Interdiscip Rev Syst Biol Med. 2013 Jan-Feb; 5(1):55-71. PMID: 23188744.
      View in: PubMed
    19. Smith LR, Chambers HG, Subramaniam S, Lieber RL. Transcriptional abnormalities of hamstring muscle contractures in children with cerebral palsy. PLoS One. 2012; 7(8):e40686. PMID: 22956992.
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    20. Smith LR, Fowler-Gerace LH, Gerace-Fowler L, Lieber RL. Muscle extracellular matrix applies a transverse stress on fibers with axial strain. J Biomech. 2011 May 17; 44(8):1618-20. PMID: 21450292.
      View in: PubMed
    21. Smith LR, Lee KS, Ward SR, Chambers HG, Lieber RL. Hamstring contractures in children with spastic cerebral palsy result from a stiffer extracellular matrix and increased in vivo sarcomere length. J Physiol. 2011 May 15; 589(Pt 10):2625-39. PMID: 21486759.
      View in: PubMed
    22. Gillies AR, Smith LR, Lieber RL, Varghese S. Method for decellularizing skeletal muscle without detergents or proteolytic enzymes. Tissue Eng Part C Methods. 2011 Apr; 17(4):383-9. PMID: 20973753.
      View in: PubMed
    23. Smith LR, Pontén E, Hedström Y, Ward SR, Chambers HG, Subramaniam S, Lieber RL. Novel transcriptional profile in wrist muscles from cerebral palsy patients. BMC Med Genomics. 2009 Jul 14; 2:44. PMID: 19602279.
      View in: PubMed