Lucas Robert Smith

Title(s)Assistant Professor, Physical Medicine and Rehabilitation
SchoolSchool of Medicine
Address189 Briggs Hall
CA 95616
Phone530-752-2930
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    The role of collagen organization in determination of fibrotic muscle function and regeneration
    NIH R00AR067867Sep 1, 2018 - Jul 31, 2021
    Role: Principal Investigator
    The role of collagen organization in determination of fibrotic muscle function and regeneration
    NIH K99AR067867Jun 1, 2016 - Aug 31, 2018
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Skeletal Muscle Spheroids as Building Blocks for Engineered Muscle Tissue. ACS Biomater Sci Eng. 2024 Jan 08; 10(1):497-506. Johnson N, Filler AC, Sethi A, Smith LR, Leach JK. PMID: 38113146; PMCID: PMC10777344.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Alignment, cross linking, and beyond: a collagen architect's guide to the skeletal muscle extracellular matrix. Am J Physiol Cell Physiol. 2023 10 01; 325(4):C1017-C1030. Wohlgemuth RP, Brashear SE, Smith LR. PMID: 37661921; PMCID: PMC10635663.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Thrown for a loop: fibro-adipogenic progenitors in skeletal muscle fibrosis. Am J Physiol Cell Physiol. 2023 10 01; 325(4):C895-C906. Loomis T, Smith LR. PMID: 37602412.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. The extracellular matrix of dystrophic mouse diaphragm accounts for the majority of its passive stiffness and is resistant to collagenase digestion. Matrix Biol Plus. 2023 Jun; 18:100131. Wohlgemuth RP, Feitzinger RM, Henricson KE, Dinh DT, Brashear SE, Smith LR. PMID: 36970609; PMCID: PMC10036937.
      View in: PubMed   Mentions: 3  
    5. Engineered multi-functional, pro-angiogenic collagen-based scaffolds loaded with endothelial cells promote large deep burn wound healing. Front Pharmacol. 2023; 14:1125209. Song H, Gao K, Hao D, Li A, Liu R, Anggito B, Yin B, Jin Q, Dartora V, Lam KS, Smith LR, Panitch A, Zhou J, Farmer DL, Wang A. PMID: 36937891; PMCID: PMC10014525.
      View in: PubMed   Mentions: 2  
    6. Mesenchymal stromal cell spheroids in sulfated alginate enhance muscle regeneration. Acta Biomater. 2023 01 01; 155:271-281. Gionet-Gonzales MA, Gresham RCH, Griffin KH, Casella A, Wohlgemuth RP, Ramos-Rodriguez DH, Lowen J, Smith LR, Leach JK. PMID: 36328130.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Collagen cross-links scale with passive stiffness in dystrophic mouse muscles, but are not altered with administration of a lysyl oxidase inhibitor. PLoS One. 2022; 17(10):e0271776. Brashear SE, Wohlgemuth RP, Hu LY, Jbeily EH, Christiansen BA, Smith LR. PMID: 36302059; PMCID: PMC9612445.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    8. Chronic Kidney Disease is Associated With Attenuated Plasma Metabolome Response to Oral Glucose Tolerance Testing. J Ren Nutr. 2023 03; 33(2):316-325. Ahmadi A, Huda MN, Bennett BJ, Gamboa J, Zelnick LR, Smith LR, Chondronikola M, Raftery D, de Boer IH, Roshanravan B. PMID: 36270479.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Myofibrillar Lattice Remodeling Is a Structural Cytoskeletal Predictor of Diaphragm Muscle Weakness in a Fibrotic mdx (mdx Cmah-/-) Model. Int J Mol Sci. 2022 Sep 16; 23(18). Ritter P, Nübler S, Buttgereit A, Smith LR, Mühlberg A, Bauer J, Michael M, Kreiß L, Haug M, Barton E, Friedrich O. PMID: 36142754; PMCID: PMC9500669.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    10. Matrix stiffness and architecture drive fibro-adipogenic progenitors' activation into myofibroblasts. Sci Rep. 2022 08 09; 12(1):13582. Loomis T, Hu LY, Wohlgemuth RP, Chellakudam RR, Muralidharan PD, Smith LR. PMID: 35945422; PMCID: PMC9363488.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. A mutation in desmin makes skeletal muscle less vulnerable to acute muscle damage after eccentric loading in rats. FASEB J. 2021 09; 35(9):e21860. Langer HT, Mossakowski AA, Avey AM, Wohlgemuth RP, Smith LR, Zbinden-Foncea H, Baar K. PMID: 34411340; PMCID: PMC9292853.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. Skeletal muscle progenitors are sensitive to collagen architectural features of fibril size and cross linking. Am J Physiol Cell Physiol. 2021 08 01; 321(2):C330-C342. Hu LY, Mileti CJ, Loomis T, Brashear SE, Ahmad S, Chellakudam RR, Wohlgemuth RP, Gionet-Gonzales MA, Leach JK, Smith LR. PMID: 34191625; PMCID: PMC8424678.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    13. Passive stiffness of fibrotic skeletal muscle in mdx mice relates to collagen architecture. J Physiol. 2021 02; 599(3):943-962. Brashear SE, Wohlgemuth RP, Gonzalez G, Smith LR. PMID: 33247944; PMCID: PMC9926974.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    14. Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization. Sci Rep. 2020 11 04; 10(1):19065. Chen D, Smith LR, Khandekar G, Patel P, Yu CK, Zhang K, Chen CS, Han L, Wells RG. PMID: 33149218; PMCID: PMC7642422.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    15. Matrix Metalloproteinase 13 from Satellite Cells is Required for Efficient Muscle Growth and Regeneration. Cell Physiol Biochem. 2020 Apr 11; 54(3):333-353. Smith LR, Kok HJ, Zhang B, Chung D, Spradlin RA, Rakoczy KD, Lei H, Boesze-Battaglia K, Barton ER. PMID: 32275813; PMCID: PMC7293591.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    16. Impaired skeletal muscle mitochondrial bioenergetics and physical performance in chronic kidney disease. JCI Insight. 2020 03 12; 5(5). Kestenbaum B, Gamboa J, Liu S, Ali AS, Shankland E, Jue T, Giulivi C, Smith LR, Himmelfarb J, de Boer IH, Conley K, Roshanravan B. PMID: 32161192; PMCID: PMC7141399.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    17. Contribution of extracellular matrix components to the stiffness of skeletal muscle contractures in patients with cerebral palsy. Connect Tissue Res. 2021 05; 62(3):287-298. Smith LR, Pichika R, Meza RC, Gillies AR, Baliki MN, Chambers HG, Lieber RL. PMID: 31779492; PMCID: PMC7253322.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    18. Skeletal muscle explants: ex-vivo models to study cellular behavior in a complex tissue environment. Connect Tissue Res. 2020 May-Jul; 61(3-4):248-261. Smith LR, Meyer GA. PMID: 31492079; PMCID: PMC8837600.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin. Muscle Nerve. 2019 10; 60(4):464-473. Barton ER, Pham J, Brisson BK, Park S, Smith LR, Liu M, Tian Z, Hammers DW, Vassilakos G, Sweeney HL. PMID: 31323135; PMCID: PMC6771521.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    20. Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. J Cell Biol. 2019 08 05; 218(8):2545-2563. Xia Y, Pfeifer CR, Zhu K, Irianto J, Liu D, Pannell K, Chen EJ, Dooling LJ, Tobin MP, Wang M, Ivanovska IL, Smith LR, Greenberg RA, Discher DE. PMID: 31239284; PMCID: PMC6683732.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    21. Constricted migration modulates stem cell differentiation. Mol Biol Cell. 2019 07 22; 30(16):1985-1999. Smith LR, Irianto J, Xia Y, Pfeifer CR, Discher DE. PMID: 31188712; PMCID: PMC6727770.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    22. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. J Cell Biol. 2018 11 05; 217(11):3796-3808. Xia Y, Ivanovska IL, Zhu K, Smith L, Irianto J, Pfeifer CR, Alvey CM, Ji J, Liu D, Cho S, Bennett RR, Liu AJ, Greenberg RA, Discher DE. PMID: 30171044; PMCID: PMC6219729.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    23. Regulation of fibrosis in muscular dystrophy. Matrix Biol. 2018 08; 68-69:602-615. Smith LR, Barton ER. PMID: 29408413; PMCID: PMC6519730.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    24. Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces. Biophys J. 2018 01 23; 114(2):450-461. Ban E, Franklin JM, Nam S, Smith LR, Wang H, Wells RG, Chaudhuri O, Liphardt JT, Shenoy VB. PMID: 29401442; PMCID: PMC5984980.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    25. Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics. Physiology (Bethesda). 2018 Jan 01; 33(1):16-25. Smith LR, Cho S, Discher DE. PMID: 29212889; PMCID: PMC5866410.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    26. SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors. Curr Biol. 2017 Jul 24; 27(14):2065-2077.e6. Alvey CM, Spinler KR, Irianto J, Pfeifer CR, Hayes B, Xia Y, Cho S, Dingal PCPD, Hsu J, Smith L, Tewari M, Discher DE. PMID: 28669759; PMCID: PMC5846676.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    27. Surface water mitigates the anti-metamorphic effects of elevated perchlorate concentrations in New Mexico spadefoot toad larvae (Spea multiplicata). Environ Sci Pollut Res Int. 2017 Jul; 24(21):17839-17844. Sandoz MA, Wages M, Wooten KJ, Clendening SL, Smith LR, Mulhearn B, Smith PN. PMID: 28608158.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    28. Mechanosensing of matrix by stem cells: From matrix heterogeneity, contractility, and the nucleus in pore-migration to cardiogenesis and muscle stem cells in vivo. Semin Cell Dev Biol. 2017 11; 71:84-98. Smith L, Cho S, Discher DE. PMID: 28587976; PMCID: PMC5659905.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    29. Matrix Mechanosensing: From Scaling Concepts in 'Omics Data to Mechanisms in the Nucleus, Regeneration, and Cancer. Annu Rev Biophys. 2017 05 22; 46:295-315. Discher DE, Smith L, Cho S, Colasurdo M, García AJ, Safran S. PMID: 28532215; PMCID: PMC5444306.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    30. Increased collagen cross-linking is a signature of dystrophin-deficient muscle. Muscle Nerve. 2016 06; 54(1):71-8. Smith LR, Hammers DW, Sweeney HL, Barton ER. PMID: 26616495; PMCID: PMC5067682.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    31. Masticatory muscles of mouse do not undergo atrophy in space. FASEB J. 2015 Jul; 29(7):2769-79. Philippou A, Minozzo FC, Spinazzola JM, Smith LR, Lei H, Rassier DE, Barton ER. PMID: 25795455; PMCID: PMC4478801.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    32. SMASH - semi-automatic muscle analysis using segmentation of histology: a MATLAB application. Skelet Muscle. 2014; 4:21. Smith LR, Barton ER. PMID: 25937889; PMCID: PMC4417508.
      View in: PubMed   Mentions: 112     Fields:    
    33. Targeting latent TGFβ release in muscular dystrophy. Sci Transl Med. 2014 Oct 22; 6(259):259ra144. Ceco E, Bogdanovich S, Gardner B, Miller T, DeJesus A, Earley JU, Hadhazy M, Smith LR, Barton ER, Molkentin JD, McNally EM. PMID: 25338755; PMCID: PMC4337885.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    34. Influencing the secretion of myogenic factors from mesenchymal stem cells. Stem Cell Res Ther. 2014 Aug 13; 5(4):96. Smith LR. PMID: 25157834; PMCID: PMC4282150.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    35. Collagen content does not alter the passive mechanical properties of fibrotic skeletal muscle in mdx mice. Am J Physiol Cell Physiol. 2014 May 15; 306(10):C889-98. Smith LR, Barton ER. PMID: 24598364; PMCID: PMC4024713.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    36. 6 Skeletal muscle changes due to cerebral palsy. . 2014 Jan 1; 135-155. Lieber LR, Smith SL. .
      View in: Publisher Site   Mentions:
    37. Matrix metalloproteinase 13 is a new contributor to skeletal muscle regeneration and critical for myoblast migration. Am J Physiol Cell Physiol. 2013 Sep; 305(5):C529-38. Lei H, Leong D, Smith LR, Barton ER. PMID: 23761625; PMCID: PMC3761151.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    38. Reduced satellite cell population may lead to contractures in children with cerebral palsy. Dev Med Child Neurol. 2013 Mar; 55(3):264-70. Smith LR, Chambers HG, Lieber RL. PMID: 23210987; PMCID: PMC4054943.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    39. Systems analysis of biological networks in skeletal muscle function. Wiley Interdiscip Rev Syst Biol Med. 2013 Jan-Feb; 5(1):55-71. Smith LR, Meyer G, Lieber RL. PMID: 23188744; PMCID: PMC4076960.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    40. Transcriptional abnormalities of hamstring muscle contractures in children with cerebral palsy. PLoS One. 2012; 7(8):e40686. Smith LR, Chambers HG, Subramaniam S, Lieber RL. PMID: 22956992; PMCID: PMC3431909.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    41. Response to Letter to the Editor: ‘Poisson's ratios in anisotropic materials at finite strains; comment on short communication by Smith et al. (2011)’. Journal of Biomechanics. 2012 Jun 1; 45(10):1859-1860. Smith SL, Fowler-Gerace FL, Lieber LR. .
      View in: Publisher Site   Mentions:
    42. Corrigendum to “Muscle extracellular matrix applies a transverse stress on fibers with axial strain” [J. Biomech. 44 (2011) 1618–1620]. Journal of Biomechanics. 2012 Jan 1; 45(1):207. Smith SL, Fowler-Gerace FL, Lieber LR. .
      View in: Publisher Site   Mentions:
    43. Muscle extracellular matrix applies a transverse stress on fibers with axial strain. J Biomech. 2011 May 17; 44(8):1618-20. Smith LR, Fowler-Gerace LH, Gerace-Fowler L, Lieber RL. PMID: 21450292; PMCID: PMC3085660.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    44. Hamstring contractures in children with spastic cerebral palsy result from a stiffer extracellular matrix and increased in vivo sarcomere length. J Physiol. 2011 May 15; 589(Pt 10):2625-39. Smith LR, Lee KS, Ward SR, Chambers HG, Lieber RL. PMID: 21486759; PMCID: PMC3115830.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansCells
    45. Method for decellularizing skeletal muscle without detergents or proteolytic enzymes. Tissue Eng Part C Methods. 2011 Apr; 17(4):383-9. Gillies AR, Smith LR, Lieber RL, Varghese S. PMID: 20973753; PMCID: PMC3065727.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    46. Novel transcriptional profile in wrist muscles from cerebral palsy patients. BMC Med Genomics. 2009 Jul 14; 2:44. Smith LR, Pontén E, Hedström Y, Ward SR, Chambers HG, Subramaniam S, Lieber RL. PMID: 19602279; PMCID: PMC2722667.
      View in: PubMed   Mentions: 42     Fields:    
    47. Cooperative cross-bridge activation of thin filaments contributes to the Frank-Starling mechanism in cardiac muscle. Biophys J. 2009 May 06; 96(9):3692-702. Smith L, Tainter C, Regnier M, Martyn DA. PMID: 19413974; PMCID: PMC3325146.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    48. The effects of force inhibition by sodium vanadate on cross-bridge binding, force redevelopment, and Ca2+ activation in cardiac muscle. Biophys J. 2007 Jun 15; 92(12):4379-90. Martyn DA, Smith L, Kreutziger KL, Xu S, Yu LC, Regnier M. PMID: 17400698; PMCID: PMC1877787.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells