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Keith Baar

TitlePROF-AY
InstitutionUniversity of California Davis
DepartmentPhysiology and Membrane Biology
Address1275 Med Sci Drive
CA 95616
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hughes DC, Marcotte GR, Baehr LM, West DWD, Marshall AG, Ebert SM, Davidyan A, Adams CM, Bodine SC, Baar K. Alterations in the muscle force transfer apparatus in aged rats during unloading and reloading: Impact of microRNA-31. J Physiol. 2018 May 03. PMID: 29726007.
      View in: PubMed
    2. Heaton LE, Davis JK, Rawson ES, Nuccio RP, Witard OC, Stein KW, Baar K, Carter JM, Baker LB. Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview. Sports Med. 2017 Nov; 47(11):2201-2218. PMID: 28702900.
      View in: PubMed
    3. Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2017 Sep 05; 26(3):539-546.e5. PMID: 28877457.
      View in: PubMed
    4. Lee-Barthel A, Baar K, West DWD. Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model. J Vis Exp. 2017 06 11; (124). PMID: 28654031.
      View in: PubMed
    5. Hughes DC, Ellefsen S, Baar K. Adaptations to Endurance and Strength Training. Cold Spring Harb Perspect Med. 2017 May 10. PMID: 28490537.
      View in: PubMed
    6. Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH. DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metab. 2017 May 02; 25(5):1135-1146.e7. PMID: 28467930.
      View in: PubMed
    7. Hughes DC, Marcotte GR, Marshall AG, West DWD, Baehr LM, Wallace MA, Saleh PM, Bodine SC, Baar K. Age-related Differences in Dystrophin: Impact on Force Transfer Proteins, Membrane Integrity, and Neuromuscular Junction Stability. J Gerontol A Biol Sci Med Sci. 2017 May 01; 72(5):640-648. PMID: 27382038.
      View in: PubMed
    8. Baar K. Minimizing Injury and Maximizing Return to Play: Lessons from Engineered Ligaments. Sports Med. 2017 Mar; 47(Suppl 1):5-11. PMID: 28332110.
      View in: PubMed
    9. West DW, Baehr LM, Marcotte GR, Chason CM, Tolento L, Gomes AV, Bodine SC, Baar K. Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle. J Physiol. 2016 Jan 15; 594(2):453-68. PMID: 26548696; PMCID: PMC4713726 [Available on 01/15/17].
    10. Khodabukus A, Baehr LM, Bodine SC, Baar K. Role of contraction duration in inducing fast-to-slow contractile and metabolic protein and functional changes in engineered muscle. J Cell Physiol. 2015 Oct; 230(10):2489-97. PMID: 25857846.
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    11. West DW, Lee-Barthel A, McIntyre T, Shamim B, Lee CA, Baar K. The exercise-induced biochemical milieu enhances collagen content and tensile strength of engineered ligaments. J Physiol. 2015 Oct 15; 593(20):4665-75. PMID: 26282066; PMCID: PMC4606526 [Available on 10/15/16].
    12. Khodabukus A, Baar K. Contractile and metabolic properties of engineered skeletal muscle derived from slow and fast phenotype mouse muscle. J Cell Physiol. 2015 Aug; 230(8):1750-7. PMID: 25335966.
      View in: PubMed
    13. Khodabukus A, Baar K. Glucose concentration and streptomycin alter in vitro muscle function and metabolism. J Cell Physiol. 2015 Jun; 230(6):1226-34. PMID: 25358470.
      View in: PubMed
    14. Hughes DC, Wallace MA, Baar K. Effects of aging, exercise, and disease on force transfer in skeletal muscle. Am J Physiol Endocrinol Metab. 2015 Jul 01; 309(1):E1-E10. PMID: 25968577; PMCID: PMC4490334.
    15. Lee CA, Lee-Barthel A, Marquino L, Sandoval N, Marcotte GR, Baar K. Estrogen inhibits lysyl oxidase and decreases mechanical function in engineered ligaments. J Appl Physiol (1985). 2015 May 15; 118(10):1250-7. PMID: 25979936.
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    16. Khodabukus A, Baar K. Streptomycin decreases the functional shift to a slow phenotype induced by electrical stimulation in engineered muscle. Tissue Eng Part A. 2015 Mar; 21(5-6):1003-12. PMID: 25333771.
      View in: PubMed
    17. Khodabukus A, Baar K. The effect of serum origin on tissue engineered skeletal muscle function. J Cell Biochem. 2014 Dec; 115(12):2198-207. PMID: 25146978.
      View in: PubMed
    18. Baar K. Using molecular biology to maximize concurrent training. Sports Med. 2014 Nov; 44 Suppl 2:S117-25. PMID: 25355186; PMCID: PMC4213370.
    19. Marcotte GR, West DW, Baar K. The molecular basis for load-induced skeletal muscle hypertrophy. Calcif Tissue Int. 2015 Mar; 96(3):196-210. PMID: 25359125; PMCID: PMC4809742.
    20. Watson K, Baar K. mTOR and the health benefits of exercise. Semin Cell Dev Biol. 2014 Dec; 36:130-9. PMID: 25218794.
      View in: PubMed
    21. Perez-Schindler J, Hamilton DL, Moore DR, Baar K, Philp A. Nutritional strategies to support concurrent training. Eur J Sport Sci. 2015; 15(1):41-52. PMID: 25159707.
      View in: PubMed
    22. Hamilton DL, Philp A, MacKenzie MG, Patton A, Towler MC, Gallagher IJ, Bodine SC, Baar K. Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation. Am J Physiol Endocrinol Metab. 2014 Aug 15; 307(4):E365-73. PMID: 24961241; PMCID: PMC4137116.
    23. Baar K. Nutrition and the adaptation to endurance training. Sports Med. 2014 May; 44 Suppl 1:S5-12. PMID: 24791912; PMCID: PMC4008803.
    24. McGee SL, Swinton C, Morrison S, Gaur V, Campbell DE, Jorgensen SB, Kemp BE, Baar K, Steinberg GR, Hargreaves M. Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress. FASEB J. 2014 Aug; 28(8):3384-95. PMID: 24732133.
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    25. Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD. Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs. 2014 Apr; 25(4):433-46. PMID: 24525589; PMCID: PMC3947856.
    26. Philp A, MacKenzie MG, Belew MY, Towler MC, Corstorphine A, Papalamprou A, Hardie DG, Baar K. Glycogen content regulates peroxisome proliferator activated receptor-? (PPAR-?) activity in rat skeletal muscle. PLoS One. 2013; 8(10):e77200. PMID: 24146969.
      View in: PubMed
    27. West DW, Baar K. May the Force move you: TSC-ing the mechanical activation of mTOR. J Physiol. 2013 Sep 15; 591(18):4369-70. PMID: 24037132; PMCID: PMC3784182.
    28. Hwee DT, Baehr LM, Philp A, Baar K, Bodine SC. Maintenance of muscle mass and load-induced growth in Muscle RING Finger 1 null mice with age. Aging Cell. 2014 Feb; 13(1):92-101. PMID: 23941502; PMCID: PMC3947038.
    29. Aguirre N, van Loon LJ, Baar K. The role of amino acids in skeletal muscle adaptation to exercise. Nestle Nutr Inst Workshop Ser. 2013; 76:85-102. PMID: 23899757.
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    30. Hagerty P, Lee A, Calve S, Lee CA, Vidal M, Baar K. The effect of growth factors on both collagen synthesis and tensile strength of engineered human ligaments. Biomaterials. 2012 Sep; 33(27):6355-61. PMID: 22698725.
      View in: PubMed
    31. Philp A, Baar K. Fine-tuning metabolism--how products of contraction regulate skeletal muscle adaptation. Am J Physiol Endocrinol Metab. 2012 Jun 01; 302(11):E1313-4. PMID: 22436694.
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    32. Philp A, Hargreaves M, Baar K. More than a store: regulatory roles for glycogen in skeletal muscle adaptation to exercise. Am J Physiol Endocrinol Metab. 2012 Jun 01; 302(11):E1343-51. PMID: 22395109.
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    33. Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JH. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 2012 Feb 03; 148(3):421-33. PMID: 22304913; PMCID: PMC3431801.
    34. Philp A, Burke LM, Baar K. Altering endogenous carbohydrate availability to support training adaptations. Nestle Nutr Inst Workshop Ser. 2011; 69:19-31; discussion 31-7. PMID: 22301834.
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    35. Bodine SC, Baar K. Analysis of skeletal muscle hypertrophy in models of increased loading. Methods Mol Biol. 2012; 798:213-29. PMID: 22130839.
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    36. Khodabukus A, Baar K. Defined electrical stimulation emphasizing excitability for the development and testing of engineered skeletal muscle. Tissue Eng Part C Methods. 2012 May; 18(5):349-57. PMID: 22092374.
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    37. Philp A, Belew MY, Evans A, Pham D, Sivia I, Chen A, Schenk S, Baar K. The PGC-1a-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes. Am J Physiol Regul Integr Comp Physiol. 2011 Oct; 301(4):R864-72. PMID: 21795630; PMCID: PMC3197342.
    38. Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE, Olfert IM, McCurdy CE, Marcotte GR, Hogan MC, Baar K, Schenk S. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem. 2011 Sep 02; 286(35):30561-70. PMID: 21757760; PMCID: PMC3162416.
    39. Baar K, Hargreaves M. Understanding the regulation of muscle plasticity. J Appl Physiol (1985). 2011 Jan; 110(1):256-7. PMID: 21088204.
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    40. Philp A, Hamilton DL, Baar K. Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1. J Appl Physiol (1985). 2011 Feb; 110(2):561-8. PMID: 21071597.
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    41. Hulston CJ, Venables MC, Mann CH, Martin C, Philp A, Baar K, Jeukendrup AE. Training with low muscle glycogen enhances fat metabolism in well-trained cyclists. Med Sci Sports Exerc. 2010 Nov; 42(11):2046-55. PMID: 20351596.
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    42. Khodabukus A, Baar K. Regulating fibrinolysis to engineer skeletal muscle from the C2C12 cell line. Tissue Eng Part C Methods. 2009 Sep; 15(3):501-11. PMID: 19191517.
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    43. Baar K. The signaling underlying FITness. Appl Physiol Nutr Metab. 2009 Jun; 34(3):411-9. PMID: 19448707.
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    44. MacKenzie MG, Hamilton DL, Murray JT, Taylor PM, Baar K. mVps34 is activated following high-resistance contractions. J Physiol. 2009 Jan 15; 587(1):253-60. PMID: 19015198; PMCID: PMC2670038.
    45. Baar K, Hardie DG. Small molecules can have big effects on endurance. Nat Chem Biol. 2008 Oct; 4(10):583-4. PMID: 18800044.
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    46. McGee SL, Mustard KJ, Hardie DG, Baar K. Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. J Physiol. 2008 Mar 15; 586(6):1731-41. PMID: 18202101; PMCID: PMC2327866.
    47. Hamilton DL, Baar K. Muscle growth: no IGFs, ands, or buts. J Physiol. 2008 Jan 01; 586(1):5-6. PMID: 18167368; PMCID: PMC2375563.
    48. Cuthbertson DJ, Babraj JA, Mustard KJ, Towler MC, Green KA, Wackerhage H, Leese GP, Baar K, Thomason-Hughes M, Sutherland C, Hardie DG, Rennie MJ. 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men. Diabetes. 2007 Aug; 56(8):2078-84. PMID: 17513706.
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    49. Baar K. Training for endurance and strength: lessons from cell signaling. Med Sci Sports Exerc. 2006 Nov; 38(11):1939-44. PMID: 17095927.
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    50. Baar K. To perform your best: work hard not long. J Physiol. 2006 Sep 15; 575(Pt 3):690. PMID: 16873398; PMCID: PMC1995683.
    51. Lockhart NC, Baar K, Mazzeo RS, Brooks SV. Activation of Akt as a potential mediator of adaptations that reduce muscle injury. Med Sci Sports Exerc. 2006 Jun; 38(6):1058-64. PMID: 16775545.
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    52. Baar K. Involvement of PPAR gamma co-activator-1, nuclear respiratory factors 1 and 2, and PPAR alpha in the adaptive response to endurance exercise. Proc Nutr Soc. 2004 May; 63(2):269-73. PMID: 15294042.
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    53. Baar K, Wende AR, Jones TE, Marison M, Nolte LA, Chen M, Kelly DP, Holloszy JO. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J. 2002 Dec; 16(14):1879-86. PMID: 12468452.
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    54. Chen YW, Nader GA, Baar KR, Fedele MJ, Hoffman EP, Esser KA. Response of rat muscle to acute resistance exercise defined by transcriptional and translational profiling. J Physiol. 2002 Nov 15; 545(Pt 1):27-41. PMID: 12433947; PMCID: PMC2290672.