Alexey A Tomilov

Title(s)Associate Scientist, School of Veterinary Medicine
SchoolSchool of Veterinary Medicine
Address3011 VM3B
CA 95616
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer's mouse model and stimulates synaptic plasticity pathway enzymes. Commun Biol. 2024 Feb 16; 7(1):195. Di Lucente J, Persico G, Zhou Z, Jin LW, Ramsey JJ, Rutkowsky JM, Montgomery CM, Tomilov A, Kim K, Giorgio M, Maezawa I, Cortopassi GA. PMID: 38366025; PMCID: PMC10873348.
      View in: PubMed   Mentions: Translation:HumansAnimals
    2. The ketone body β-hydroxybutyrate shifts microglial metabolism and suppresses amyloid-β oligomer-induced inflammation in human microglia. FASEB J. 2023 11; 37(11):e23261. Jin LW, Di Lucente J, Ruiz Mendiola U, Suthprasertporn N, Tomilov A, Cortopassi G, Kim K, Ramsey JJ, Maezawa I. PMID: 37878335.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. Shc inhibitor idebenone ameliorates liver injury and fibrosis in dietary NASH in mice. J Biochem Mol Toxicol. 2021 Oct; 35(10):e22876. Jiang JX, Tomilov A, Montgomery C, Hui CK, Török NJ, Cortopassi G. PMID: 34369032; PMCID: PMC9138663.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Novel mTORC1 Inhibitors Kill Glioblastoma Stem Cells. Pharmaceuticals (Basel). 2020 Nov 24; 13(12). Sandoval JA, Tomilov A, Datta S, Allen S, O'Donnell R, Sears T, Woolard K, Kovalskyy D, Angelastro JM, Cortopassi G. PMID: 33255358; PMCID: PMC7761300.
      View in: PubMed   Mentions: 1  
    5. Novel idebenone analogs block Shc's access to insulin receptor to improve insulin sensitivity. Biomed Pharmacother. 2020 Dec; 132:110823. Hui C, Tomilov A, Garcia C, Jiang X, Fash DM, Khdour OM, Rosso C, Filippini G, Prato M, Graham J, Hecht S, Havel P, Cortopassi G. PMID: 33045613.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Nonphagocytic Activation of NOX2 Is Implicated in Progressive Nonalcoholic Steatohepatitis During Aging. Hepatology. 2020 10; 72(4):1204-1218. Jiang JX, Fish SR, Tomilov A, Li Y, Fan W, Dehnad A, Gae D, Das S, Mozes G, Charville GW, Ramsey J, Cortopassi G, Török NJ. PMID: 31950520; PMCID: PMC7478166.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    7. Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer. Mitochondrion. 2020 01; 50:19-24. Allen SA, Datta S, Sandoval J, Tomilov A, Sears T, Woolard K, Angelastro JM, Cortopassi GA. PMID: 31654752.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition. Pharmacol Res. 2018 11; 137:89-103. Tomilov A, Allen S, Hui CK, Bettaieb A, Cortopassi G. PMID: 30290222.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    9. Small molecules bind human mTOR protein and inhibit mTORC1 specifically. Biochem Pharmacol. 2018 09; 155:298-304. Allen SA, Tomilov A, Cortopassi GA. PMID: 30028993.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2018 May 01; 27(5):1156. Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA. PMID: 29719228; PMCID: PMC5957496.
      View in: PubMed   Mentions: 23     Fields:    
    11. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2017 Sep 05; 26(3):539-546.e5. Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA. PMID: 28877457; PMCID: PMC5609489.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    12. In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride. Environ Health Perspect. 2017 08 22; 125(8):087015. Datta S, He G, Tomilov A, Sahdeo S, Denison MS, Cortopassi G. PMID: 28885978; PMCID: PMC5783672.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    13. Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system. PLoS One. 2017; 12(6):e0177761. Scharadin TM, He W, Yiannakou Y, Tomilov AA, Saldana M, Cortopassi GA, Carraway KL, Coleman MA, Henderson PT. PMID: 28586369; PMCID: PMC5460842.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Galectin-3 regulates inflammasome activation in cholestatic liver injury. FASEB J. 2016 12; 30(12):4202-4213. Tian J, Yang G, Chen HY, Hsu DK, Tomilov A, Olson KA, Dehnad A, Fish SR, Cortopassi G, Zhao B, Liu FT, Gershwin ME, Török NJ, Jiang JX. PMID: 27630169; PMCID: PMC5102125.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    15. Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations. Mitochondrion. 2016 09; 30:177-86. Datta S, Tomilov A, Cortopassi G. PMID: 27497748; PMCID: PMC5039017.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    16. Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver. Biochem Biophys Rep. 2016 Sep; 7:273-286. Hagopian K, Kim K, López-Dominguez JA, Tomilov AA, Cortopassi GA, Ramsey JJ. PMID: 28133633; PMCID: PMC5267479.
      View in: PubMed   Mentions: 3  
    17. p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria. J Biol Chem. 2016 Jun 10; 291(24):12575-12585. Tomilov A, Tomilova N, Shan Y, Hagopian K, Bettaieb A, Kim K, Pelicci PG, Haj F, Ramsey J, Cortopassi G. PMID: 27059956; PMCID: PMC4933453.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    18. Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins. PLoS One. 2015; 10(4):e0124204. Hagopian K, Tomilov AA, Kim K, Cortopassi GA, Ramsey JJ. PMID: 25880638; PMCID: PMC4400099.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    19. Shc depletion stimulates brown fat activity in vivo and in vitro. Aging Cell. 2014 Dec; 13(6):1049-58. Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, Hagopian K, Connell M, Fong J, Rowland D, Griffey S, Ramsey J, Haj F, Cortopassi G. PMID: 25257068; PMCID: PMC4244234.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    20. High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects. Mitochondrion. 2014 Jul; 17:116-25. Sahdeo S, Tomilov A, Komachi K, Iwahashi C, Datta S, Hughes O, Hagerman P, Cortopassi G. PMID: 25034306; PMCID: PMC4142054.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    21. The influence of Shc proteins on life span in mice. J Gerontol A Biol Sci Med Sci. 2014 Oct; 69(10):1177-85. Ramsey JJ, Tran D, Giorgio M, Griffey SM, Koehne A, Laing ST, Taylor SL, Kim K, Cortopassi GA, Lloyd KC, Hagopian K, Tomilov AA, Migliaccio E, Pelicci PG, McDonald RB. PMID: 24336818; PMCID: PMC4172037.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    22. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc. 2012 Oct; 1(5):e003012. Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, Cortopassi G, Chiamvimonvat N, Bers DM, Votruba M, Knowlton AA. PMID: 23316298; PMCID: PMC3541627.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    23. Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis. Metabolism. 2012 Dec; 61(12):1703-13. Hagopian K, Tomilov AA, Tomilova N, Kim K, Taylor SL, Lam AK, Cortopassi GA, McDonald RB, Ramsey JJ. PMID: 22683097; PMCID: PMC3442136.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    24. Hepatic Src homology phosphatase 2 regulates energy balance in mice. Endocrinology. 2012 Jul; 153(7):3158-69. Nagata N, Matsuo K, Bettaieb A, Bakke J, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Jung DY, Ramsey JJ, Kim JK, Cortopassi G, Havel PJ, Haj FG. PMID: 22619361; PMCID: PMC3380313.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    25. The TvPirin gene is necessary for haustorium development in the parasitic plant Triphysaria versicolor. Plant Physiol. 2012 Feb; 158(2):1046-53. Bandaranayake PC, Tomilov A, Tomilova NB, Ngo QA, Wickett N, dePamphilis CW, Yoder JI. PMID: 22128136; PMCID: PMC3271741.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    26. The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell. 2011 Feb; 10(1):55-65. Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA. PMID: 21040401; PMCID: PMC4157392.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    27. A single-electron reducing quinone oxidoreductase is necessary to induce haustorium development in the root parasitic plant Triphysaria. Plant Cell. 2010 Apr; 22(4):1404-19. Bandaranayake PC, Filappova T, Tomilov A, Tomilova NB, Jamison-McClung D, Ngo Q, Inoue K, Yoder JI. PMID: 20424175; PMCID: PMC2879752.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    28. Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem. 2010 Jan 08; 285(2):1153-65. Tomilov AA, Bicocca V, Schoenfeld RA, Giorgio M, Migliaccio E, Ramsey JJ, Hagopian K, Pelicci PG, Cortopassi GA. PMID: 19892704; PMCID: PMC2801244.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    29. Engineering host resistance against parasitic weeds with RNA interference. Pest Manag Sci. 2009 May; 65(5):460-6. Yoder JI, Gunathilake P, Wu B, Tomilova N, Tomilov AA. PMID: 19235710.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    30. Trans-specific gene silencing between host and parasitic plants. Plant J. 2008 Nov; 56(3):389-97. Tomilov AA, Tomilova NB, Wroblewski T, Michelmore R, Yoder JI. PMID: 18643992.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    31. HOST DETECTION BY ROOT PARASITES: INSIGHTS FROM TRANSCRIPTION PROFILES. . 2007 Jun 1; 33-45. Yoder YJ, Reagan RR, Tomilov TA, Tomilova TN, Torres TM. .
      View in: Publisher Site   Mentions:
    32. Agrobacterium tumefaciens and Agrobacterium rhizogenes transformed roots of the parasitic plant Triphysaria versicolor retain parasitic competence. Planta. 2007 Apr; 225(5):1059-71. Tomilov A, Tomilova N, Yoder JI. PMID: 17053892.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    33. Pscroph, a parasitic plant EST database enriched for parasite associated transcripts. BMC Plant Biol. 2005 Nov 16; 5:24. Torres MJ, Tomilov AA, Tomilova N, Reagan RL, Yoder JI. PMID: 16288663; PMCID: PMC1325228.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    34. Localized hormone fluxes and early haustorium development in the hemiparasitic plant Triphysaria versicolor. Plant Physiol. 2005 Jul; 138(3):1469-80. Tomilov AA, Tomilova NB, Abdallah I, Yoder JI. PMID: 15965023; PMCID: PMC1176418.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    35. [Identification of the gene whose mutation leads to the appearance of recessive lethal germlings in Arabidopsis thaliana]. Ontogenez. 2005 May-Jun; 36(3):222-4. Ogarkova OA, Tomilov AA, Tomilova NB, Tarasov VA. PMID: 15977805.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    36. [Identification of the gene whose mutation leads to hypocotyl tropism in Arabidopsis thaliana]. Genetika. 2005 Mar; 41(3):427-9. Ogarkova OA, Tomilov AA, Tomilova NB, Tarasov VA. PMID: 15865300.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    37. [Identification of the gene whose mutation leads to the morphological changes in the hypocotyl of Arabidopsis thaliana]. Genetika. 2005 Feb; 41(2):166-70. Ogarkova OA, Tomilov AA, Tomilova NB, Pogorelko GV, Tarasov VA. PMID: 15810605.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    38. In Vitro Haustorium Development in Roots and Root Cultures of the Hemiparasitic Plant Triphysaria Versicolor. Plant Cell, Tissue and Organ Culture (PCTOC). 2004 Jun 1; 77(3):257-265. Tomilov TA, Tomilova TN, Yoder YJ. .
      View in: Publisher Site   Mentions:
    39. [Saving insertional recessive lethal mutants of Arabidopsis thaliana]. Ontogenez. 2004 May-Jun; 35(3):220-8. Ogarkova OA, Tomilov AA, Tomilova NB, Tarasov VA. PMID: 15334825.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    40. Identification of the potential gene that controlling cotyledon development in Arabidopsis thaliana seedlings. Dokl Biol Sci. 2004 Mar-Apr; 395:161-2. Fursova OV, Pogorelko GV, Avsyuk AY, Tomilova NV, Tomilov AA, Tarasov VA, Ogarkova OA. PMID: 15255152.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    41. Two types of rDNA internal transcribed spacers (ITSs) in the Capsicum genome. Dokl Biol Sci. 2002 Nov-Dec; 387:539-41. Ryzhova NN, Goryunova SV, Tomilov AA, Kochieva EZ. PMID: 12577633.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    42. [Hormone-dependent insertional Arabidopsis thaliana mutants with decreased viability and fertility]. Genetika. 2001 Sep; 37(9):1251-7. Tomilova NB, Tomilov AA, Ogarkova OA, Soldatova OP, Tarasov VA. PMID: 11642128.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    43. [Creation of a collection of morphological insertional mutants of Arabidopsis thaliana]. Genetika. 2001 Aug; 37(8):1081-7. Ogarkova OA, Tomilova NB, Tomilov AA, Tarasov VA. PMID: 11642108.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    44. [Identification of mutant gene responsible for cotyledons necrosis in developing seedlings of Arabidopsis thaliana]. Genetika. 2001 Apr; 37(4):494-503. Tomilova NB, Tomilov AA, Ogarkova OA, Tarasov VA. PMID: 11421122.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    45. [Identification of a gene, included in control of root system development in Arabidopsis thaliana]. Genetika. 2001 Jan; 37(1):36-45. Tomilov AA, Tomilova NB, Ogarkova OA, Tarasov VA. PMID: 11234423.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    46. [Insertional mutagenesis of Arabidopsis thaliana: increase of germinating seeds transformation efficiency after sonication]. Genetika. 1999 Sep; 35(9):1214-22. Tomilov AA, Tomilova NB, Ogarkova OA, Tarasov VA. PMID: 10576057.
      View in: PubMed   Mentions:    Fields:    Translation:Animals