Laura Marcu

InstitutionUniversity of California Davis
DepartmentNeurological Surgery
Address2513 GBSF
CA 95616
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Li C, Shklover J, Parvizi M, Sherlock BE, Alfonso Garcia A, Haudenschild AK, Griffiths LG, Marcu L. Label-Free Assessment of Collagenase Digestion on Bovine Pericardium Properties by Fluorescence Lifetime Imaging. Ann Biomed Eng. 2018 Jul 12. PMID: 30003502.
      View in: PubMed
    2. Lagarto JL, Phipps JE, Faller L, Ma D, Unger J, Bec J, Griffey S, Sorger J, Farwell DG, Marcu L. Electrocautery effects on fluorescence lifetime measurements: An in vivo study in the oral cavity. J Photochem Photobiol B. 2018 May 26; 185:90-99. PMID: 29883910.
      View in: PubMed
    3. Alfonso-Garcia A, Shklover J, Sherlock BE, Panitch A, Griffiths LG, Marcu L. Fiber-based fluorescence lifetime imaging of recellularization processes on vascular tissue constructs. J Biophotonics. 2018 May 21; e201700391. PMID: 29781171.
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    4. Sherlock BE, Harvestine JN, Mitra D, Haudenschild A, Hu J, Athanasiou KA, Leach JK, Marcu L. Nondestructive assessment of collagen hydrogel cross-linking using time-resolved autofluorescence imaging. J Biomed Opt. 2018 Mar; 23(3):1-9. PMID: 29512359.
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    5. Unger J, Sun T, Chen YL, Phipps JE, Bold RJ, Darrow MA, Ma KL, Marcu L. Method for accurate registration of tissue autofluorescence imaging data with corresponding histology: a means for enhanced tumor margin assessment. J Biomed Opt. 2018 Jan; 23(1):1-11. PMID: 29297208.
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    6. Phipps JE, Gorpas D, Unger J, Darrow M, Bold RJ, Marcu L. Automated detection of breast cancer in resected specimens with fluorescence lifetime imaging. Phys Med Biol. 2017 Dec 14; 63(1):015003. PMID: 29099721.
      View in: PubMed
    7. Boppart SA, Brown JQ, Farah CS, Kho E, Marcu L, Saunders CM, Sterenborg HJCM. Label-free optical imaging technologies for rapid translation and use during intraoperative surgical and tumor margin assessment. J Biomed Opt. 2017 Dec; 23(2):1-10. PMID: 29288572.
      View in: PubMed
    8. Marcu L, Boppart SA, Hutchinson MR, Popp J, Wilson BC. Biophotonics: the big picture. J Biomed Opt. 2017 Dec; 23(2):1-7. PMID: 29275543.
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    9. Bec J, Phipps JE, Gorpas D, Ma D, Fatakdawala H, Margulies KB, Southard JA, Marcu L. In vivo label-free structural and biochemical imaging of coronary arteries using an integrated ultrasound and multispectral fluorescence lifetime catheter system. Sci Rep. 2017 Aug 21; 7(1):8960. PMID: 28827758.
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    10. Marcu L, Hillman EMC. In vivo Optical Imaging / Intravital Microscopy. J Biophotonics. 2017 Jun; 10(6-7):760-761. PMID: 28661586.
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    11. Hartl BA, Ma HSW, Hansen KS, Perks J, Kent MS, Fragoso RC, Marcu L. The effect of radiation dose on the onset and progression of radiation-induced brain necrosis in the rat model. Int J Radiat Biol. 2017 07; 93(7):676-682. PMID: 28306402.
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    12. Ma D, Liu J, Qi J, Marcu L. Reply to Comment: 'A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-square deconvolution with Laguerre expansion'. Phys Med Biol. 2017 02 21; 62(4):1637-1641. PMID: 28145280.
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    13. Mitra D, Fatakdawala H, Nguyen-Truong M, Creecy A, Nyman J, Marcu L, Leach JK. Detection of Pentosidine Cross-Links in Cell-Secreted Decellularized Matrices Using Time Resolved Fluorescence Spectroscopy. ACS Biomater Sci Eng. 2017 Sep 11; 3(9):1944-1954. PMID: 28944287.
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    14. Dochow S, Fatakdawala H, Phipps JE, Ma D, Bocklitz T, Schmitt M, Bishop JW, Margulies KB, Marcu L, Popp J. Comparing Raman and fluorescence lifetime spectroscopy from human atherosclerotic lesions using a bimodal probe. J Biophotonics. 2016 Sep; 9(9):958-66. PMID: 27003796; PMCID: PMC5012915 [Available on 09/01/17].
    15. Hartl BA, Hirschberg H, Marcu L, Cherry SR. Activating Photodynamic Therapy in vitro with Cerenkov Radiation Generated from Yttrium-90. J Environ Pathol Toxicol Oncol. 2016; 35(2):185-92. PMID: 27481495.
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    16. Fatakdawala H, Gorpas D, Bishop JW, Bec J, Ma D, Southard JA, Margulies KB, Marcu L. Fluorescence Lifetime Imaging Combined with Conventional Intravascular Ultrasound for Enhanced Assessment of Atherosclerotic Plaques: an Ex Vivo Study in Human Coronary Arteries. J Cardiovasc Transl Res. 2015 Jun; 8(4):253-63. PMID: 25931307; PMCID: PMC4473095.
    17. Ma D, Bec J, Gorpas D, Yankelevich D, Marcu L. Technique for real-time tissue characterization based on scanning multispectral fluorescence lifetime spectroscopy (ms-TRFS). Biomed Opt Express. 2015 Mar 01; 6(3):987-1002. PMID: 25798320; PMCID: PMC4361450.
    18. Hartl BA, Hirschberg H, Marcu L, Cherry SR. Characterizing low fluence thresholds for in vitro photodynamic therapy. Biomed Opt Express. 2015 Mar 01; 6(3):770-9. PMID: 25798302.
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    19. Fatakdawala H, Griffiths LG, Humphrey S, Marcu L. Time-resolved fluorescence spectroscopy and ultrasound backscatter microscopy for nondestructive evaluation of vascular grafts. J Biomed Opt. 2014 Aug; 19(8):080503. PMID: 25147960; PMCID: PMC4407666.
    20. Ghata N, Aldredge RC, Bec J, Marcu L. Computational analysis of the effectiveness of blood flushing with saline injection from an intravascular diagnostic catheter. Int J Numer Method Biomed Eng. 2014 Nov; 30(11):1278-93. PMID: 24953876; PMCID: PMC4429308.
    21. Ma D, Bec J, Yankelevich DR, Gorpas D, Fatakdawala H, Marcu L. Rotational multispectral fluorescence lifetime imaging and intravascular ultrasound: bimodal system for intravascular applications. J Biomed Opt. 2014 Jun; 19(6):066004. PMID: 24898604; PMCID: PMC4045254.
    22. Yankelevich DR, Ma D, Liu J, Sun Y, Sun Y, Bec J, Elson DS, Marcu L. Design and evaluation of a device for fast multispectral time-resolved fluorescence spectroscopy and imaging. Rev Sci Instrum. 2014 Mar; 85(3):034303. PMID: 24689603; PMCID: PMC3971822.
    23. Yankelevich D, González JE, Cudney RS, Ríos LA, Marcu L. Development of a new pulsed source for photoacoustic imaging based on aperiodically poled lithium niobate. Biomed Opt Express. 2014 Feb 01; 5(2):468-73. PMID: 24575341; PMCID: PMC3920877.
    24. Fatakdawala H, Poti S, Zhou F, Sun Y, Bec J, Liu J, Yankelevich DR, Tinling SP, Gandour-Edwards RF, Farwell DG, Marcu L. Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques. Biomed Opt Express. 2013; 4(9):1724-41. PMID: 24049693; PMCID: PMC3771843.
    25. Sun Y, Phipps JE, Meier J, Hatami N, Poirier B, Elson DS, Farwell DG, Marcu L. Endoscopic fluorescence lifetime imaging for in vivo intraoperative diagnosis of oral carcinoma. Microsc Microanal. 2013 Aug; 19(4):791-8. PMID: 23702007; PMCID: PMC4128621.
    26. Bec J, Ma DM, Yankelevich DR, Liu J, Ferrier WT, Southard J, Marcu L. Multispectral fluorescence lifetime imaging system for intravascular diagnostics with ultrasound guidance: in vivo validation in swine arteries. J Biophotonics. 2014 May; 7(5):281-5. PMID: 23495014; PMCID: PMC4410675.
    27. Sun Y, Xie H, Liu J, Lam M, Chaudhari AJ, Zhou F, Bec J, Yankelevich DR, Dobbie A, Tinling SL, Gandour-Edwards RF, Monsky WL, Farwell DG, Marcu L. In vivo validation of a bimodal technique combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy for diagnosis of oral carcinoma. J Biomed Opt. 2012 Nov; 17(11):116003. PMID: 23117798; PMCID: PMC3484195.
    28. Bec J, Xie H, Yankelevich DR, Zhou F, Sun Y, Ghata N, Aldredge R, Marcu L. Design, construction, and validation of a rotary multifunctional intravascular diagnostic catheter combining multispectral fluorescence lifetime imaging and intravascular ultrasound. J Biomed Opt. 2012 Oct; 17(10):106012. PMID: 23224011; PMCID: PMC3461057.
    29. Roncali E, Phipps JE, Marcu L, Cherry SR. Pulse shape discrimination and classification methods for continuous depth of interaction encoding PET detectors. Phys Med Biol. 2012 Oct 21; 57(20):6571-85. PMID: 23010690; PMCID: PMC3482627.
    30. Phipps JE, Sun Y, Fishbein MC, Marcu L. A fluorescence lifetime imaging classification method to investigate the collagen to lipid ratio in fibrous caps of atherosclerotic plaque. Lasers Surg Med. 2012 Sep; 44(7):564-71. PMID: 22886522; PMCID: PMC4083183.
    31. Xie H, Bec J, Liu J, Sun Y, Lam M, Yankelevich DR, Marcu L. Multispectral scanning time-resolved fluorescence spectroscopy (TRFS) technique for intravascular diagnosis. Biomed Opt Express. 2012 Jul 01; 3(7):1521-33. PMID: 22808425; PMCID: PMC3395478.
    32. Liu J, Sun Y, Qi J, Marcu L. A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-squares deconvolution with Laguerre expansion. Phys Med Biol. 2012 Feb 21; 57(4):843-65. PMID: 22290334; PMCID: PMC3407553.
    33. Sun Y, Responte D, Xie H, Liu J, Fatakdawala H, Hu J, Athanasiou KA, Marcu L. Nondestructive evaluation of tissue engineered articular cartilage using time-resolved fluorescence spectroscopy and ultrasound backscatter microscopy. Tissue Eng Part C Methods. 2012 Mar; 18(3):215-26. PMID: 22010819; PMCID: PMC3285603.
    34. Marcu L. Fluorescence lifetime techniques in medical applications. Ann Biomed Eng. 2012 Feb; 40(2):304-31. PMID: 22273730; PMCID: PMC3368954.
    35. Marcu L, Hartl BA. Fluorescence Lifetime Spectroscopy and Imaging in Neurosurgery. IEEE J Sel Top Quantum Electron. 2012 Jul-Aug; 18(4):1465-1477. PMID: 28053498.
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    36. Knorr F, Yankelevich DR, Liu J, Wachsmann-Hogiu S, Marcu L. Two-photon excited fluorescence lifetime measurements through a double-clad photonic crystal fiber for tissue micro-endoscopy. J Biophotonics. 2012 Jan; 5(1):14-9. PMID: 22045513; PMCID: PMC4128622.
    37. Phipps J, Sun Y, Saroufeem R, Hatami N, Fishbein MC, Marcu L. Fluorescence lifetime imaging for the characterization of the biochemical composition of atherosclerotic plaques. J Biomed Opt. 2011 Sep; 16(9):096018. PMID: 21950932; PMCID: PMC3189976.
    38. Sun Y, Chaudhari AJ, Lam M, Xie H, Yankelevich DR, Phipps J, Liu J, Fishbein MC, Cannata JM, Shung KK, Marcu L. Multimodal characterization of compositional, structural and functional features of human atherosclerotic plaques. Biomed Opt Express. 2011 Aug 01; 2(8):2288-98. PMID: 21833365; PMCID: PMC3149526.
    39. Phipps JE, Hatami N, Galis ZS, Baker JD, Fishbein MC, Marcu L. A fluorescence lifetime spectroscopy study of matrix metalloproteinases-2 and -9 in human atherosclerotic plaque. J Biophotonics. 2011 Sep; 4(9):650-8. PMID: 21770037; PMCID: PMC3239410.
    40. Sun Y, Sun Y, Stephens D, Xie H, Phipps J, Saroufeem R, Southard J, Elson DS, Marcu L. Dynamic tissue analysis using time- and wavelength-resolved fluorescence spectroscopy for atherosclerosis diagnosis. Opt Express. 2011 Feb 28; 19(5):3890-901. PMID: 21369214; PMCID: PMC3368314.
    41. Fite BZ, Decaris M, Sun Y, Sun Y, Lam A, Ho CK, Leach JK, Marcu L. Noninvasive multimodal evaluation of bioengineered cartilage constructs combining time-resolved fluorescence and ultrasound imaging. Tissue Eng Part C Methods. 2011 Apr; 17(4):495-504. PMID: 21303258; PMCID: PMC3065732.
    42. Sun Y, Hatami N, Yee M, Phipps J, Elson DS, Gorin F, Schrot RJ, Marcu L. Fluorescence lifetime imaging microscopy for brain tumor image-guided surgery. J Biomed Opt. 2010 Sep-Oct; 15(5):056022. PMID: 21054116; PMCID: PMC2966493.
    43. Meier JD, Xie H, Sun Y, Sun Y, Hatami N, Poirier B, Marcu L, Farwell DG. Time-resolved laser-induced fluorescence spectroscopy as a diagnostic instrument in head and neck carcinoma. Otolaryngol Head Neck Surg. 2010 Jun; 142(6):838-44. PMID: 20493355; PMCID: PMC3335733.
    44. Butte PV, Fang Q, Jo JA, Yong WH, Pikul BK, Black KL, Marcu L. Intraoperative delineation of primary brain tumors using time-resolved fluorescence spectroscopy. J Biomed Opt. 2010 Mar-Apr; 15(2):027008. PMID: 20459282; PMCID: PMC4171753.
    45. Farwell DG, Meier JD, Park J, Sun Y, Coffman H, Poirier B, Phipps J, Tinling S, Enepekides DJ, Marcu L. Time-resolved fluorescence spectroscopy as a diagnostic technique of oral carcinoma: Validation in the hamster buccal pouch model. Arch Otolaryngol Head Neck Surg. 2010 Feb; 136(2):126-33. PMID: 20157056; PMCID: PMC4128623.
    46. Marcu L. Fluorescence lifetime in cardiovascular diagnostics. J Biomed Opt. 2010 Jan-Feb; 15(1):011106. PMID: 20210432; PMCID: PMC2847934.
    47. Sun Y, Phipps J, Elson DS, Stoy H, Tinling S, Meier J, Poirier B, Chuang FS, Farwell DG, Marcu L. Fluorescence lifetime imaging microscopy: in vivo application to diagnosis of oral carcinoma. Opt Lett. 2009 Jul 01; 34(13):2081-3. PMID: 19572006; PMCID: PMC4083182.
    48. Sun Y, Park J, Stephens DN, Jo JA, Sun L, Cannata JM, Saroufeem RM, Shung KK, Marcu L. Development of a dual-modal tissue diagnostic system combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy. Rev Sci Instrum. 2009 Jun; 80(6):065104. PMID: 19566223; PMCID: PMC2736572.
    49. Stephens DN, Park J, Sun Y, Papaioannou T, Marcu L. Intraluminal fluorescence spectroscopy catheter with ultrasound guidance. J Biomed Opt. 2009 May-Jun; 14(3):030505. PMID: 19566287; PMCID: PMC4083184.
    50. Lo J, Chen SJ, Fang Q, Papaioannou T, Kim ES, Gundersen M, Marcu L. Performance of a diaphragmed microlens for a packaged microspectrometer. Sensors (Basel). 2009; 9(2):859-68. PMID: 22399943; PMCID: PMC3280835.
    51. Yan J, Sun Y, Zhu H, Marcu L, Revzin A. Enzyme-containing hydrogel micropatterns serving a dual purpose of cell sequestration and metabolite detection. Biosens Bioelectron. 2009 Apr 15; 24(8):2604-10. PMID: 19251408; PMCID: PMC2663022.
    52. Phipps J, Sun Y, Saroufeem R, Hatami N, Marcu L. Fluorescence lifetime imaging microscopy for the characterization of atherosclerotic plaques. Proc SPIE Int Soc Opt Eng. 2009; 7161:71612G. PMID: 19606277.
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    53. Marcu L, Jo JA, Fang Q, Papaioannou T, Reil T, Qiao JH, Baker JD, Freischlag JA, Fishbein MC. Detection of rupture-prone atherosclerotic plaques by time-resolved laser-induced fluorescence spectroscopy. Atherosclerosis. 2009 May; 204(1):156-64. PMID: 18926540; PMCID: PMC2766393.
    54. Sun Y, Liu R, Elson DS, Hollars CW, Jo JA, Park J, Sun Y, Marcu L. Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis. Opt Lett. 2008 Mar 15; 33(6):630-2. PMID: 18347733.
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    55. Liao KC, Hogen-Esch T, Richmond FJ, Marcu L, Clifton W, Loeb GE. Percutaneous fiber-optic sensor for chronic glucose monitoring in vivo. Biosens Bioelectron. 2008 May 15; 23(10):1458-65. PMID: 18304798.
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    56. Sun Y, Stephens DN, Park J, Sun Y, Marcu L, Cannata JM, Shung KK. Development of a Multi-modal Tissue Diagnostic System Combining High Frequency Ultrasound and Photoacoustic Imaging with Lifetime Fluorescence Spectroscopy. Proc IEEE Ultrason Symp. 2008; 570-573. PMID: 21894259.
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    57. Wang J, Yong WH, Sun Y, Vernier PT, Koeffler HP, Gundersen MA, Marcu L. Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis. J Biomed Opt. 2007 Jul-Aug; 12(4):044021. PMID: 17867825.
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    58. Yong WH, Butte PV, Pikul BK, Jo JA, Fang Q, Papaioannou T, Black K, Marcu L. Distinction of brain tissue, low grade and high grade glioma with time-resolved fluorescence spectroscopy. Front Biosci. 2006 May 01; 11:1255-63. PMID: 16368511; PMCID: PMC2991156.
    59. Jo JA, Fang Q, Papaioannou T, Baker JD, Dorafshar AH, Reil T, Qiao JH, Fishbein MC, Freischlag JA, Marcu L. Laguerre-based method for analysis of time-resolved fluorescence data: application to in-vivo characterization and diagnosis of atherosclerotic lesions. J Biomed Opt. 2006 Mar-Apr; 11(2):021004. PMID: 16674179; PMCID: PMC2672104.
    60. Sun Y, Vernier PT, Behrend M, Wang J, Thu MM, Gundersen M, Marcu L. Fluorescence microscopy imaging of electroperturbation in mammalian cells. J Biomed Opt. 2006 Mar-Apr; 11(2):024010. PMID: 16674200.
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    61. Butte PV, Pikul BK, Hever A, Yong WH, Black KL, Marcu L. Diagnosis of meningioma by time-resolved fluorescence spectroscopy. J Biomed Opt. 2005 Nov-Dec; 10(6):064026. PMID: 16409091; PMCID: PMC2981341.
    62. Rouhanizadeh M, Hwang J, Clempus RE, Marcu L, Lassègue B, Sevanian A, Hsiai TK. Oxidized-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine induces vascular endothelial superoxide production: implication of NADPH oxidase. Free Radic Biol Med. 2005 Dec 01; 39(11):1512-22. PMID: 16274886; PMCID: PMC2672101.
    63. Marcu L, Fang Q, Jo JA, Papaioannou T, Dorafshar A, Reil T, Qiao JH, Baker JD, Freischlag JA, Fishbein MC. In vivo detection of macrophages in a rabbit atherosclerotic model by time-resolved laser-induced fluorescence spectroscopy. Atherosclerosis. 2005 Aug; 181(2):295-303. PMID: 16039283; PMCID: PMC2672099.
    64. Ivanova OV, Marcu L, Khoo MC. A nonparametric method for analysis of fluorescence emission in combined time and wavelength dimensions. Ann Biomed Eng. 2005 Apr; 33(4):531-44. PMID: 15909659; PMCID: PMC2672102.
    65. Jo JA, Fang Q, Marcu L. Ultrafast Method for the Analysis of Fluorescence Lifetime Imaging Microscopy Data Based on the Laguerre Expansion Technique. IEEE J Quantum Electron. 2005; 11(4):835-845. PMID: 19444338.
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    66. Marcu L, Jo JA, Butte PV, Yong WH, Pikul BK, Black KL, Thompson RC. Fluorescence lifetime spectroscopy of glioblastoma multiforme. Photochem Photobiol. 2004 Jul-Aug; 80:98-103. PMID: 15339216.
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    67. Jo JA, Fang Q, Papaioannou T, Marcu L. Fast model-free deconvolution of fluorescence decay for analysis of biological systems. J Biomed Opt. 2004 Jul-Aug; 9(4):743-52. PMID: 15250761.
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    68. Papaioannou T, Preyer NW, Fang Q, Brightwell A, Carnohan M, Cottone G, Ross R, Jones LR, Marcu L. Effects of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media: an experimental and computational study at 337 nm. Appl Opt. 2004 May 10; 43(14):2846-60. PMID: 15143808.
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    69. Ashjian P, Elbarbary A, Zuk P, DeUgarte DA, Benhaim P, Marcu L, Hedrick MH. Noninvasive in situ evaluation of osteogenic differentiation by time-resolved laser-induced fluorescence spectroscopy. Tissue Eng. 2004 Mar-Apr; 10(3-4):411-20. PMID: 15165458.
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    70. Chih Liao K, Richmond F, Hogen-Esch T, Marcu L, Loeb GE. Senciltrade mark project: development of a percutaneous optical biosensor. Conf Proc IEEE Eng Med Biol Soc. 2004; 3:2082-5. PMID: 17272132.
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