Laura Marcu

Title(s)Professor, Biomedical Engineering
SchoolCollege of Engineering
Address2513 GBSF
CA 95616
Phone530-752-0288
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    Collapse Research 
    Collapse Research Activities and Funding
    Dual-modality FLIm and PSOCT for intravascular imaging of plaque in patients
    NIH R01HL157712Sep 10, 2021 - Aug 31, 2026
    Role: Principal Investigator
    Label-free fluorescence lifetime imaging for intraoperative real-time guidance of neurological procedures
    NIH R01CA250512Dec 15, 2020 - Nov 30, 2025
    Role: Principal Investigator
    Fluorescence lifetime technique for intraoperative identification of IDH mutations in brain cancer
    NIH R21CA252510Jun 17, 2020 - May 31, 2022
    Role: Principal Investigator
    Augmented reality visualization for intraoperative guidance based on fluorescence lifetime
    NIH R03EB026819Sep 1, 2018 - Jun 30, 2021
    Role: Principal Investigator
    A fiber-coupled multimodal imaging platform for in vitro assessment of engineering tissue
    NIH R03EB025565Sep 30, 2017 - Aug 31, 2020
    Role: Principal Investigator
    Bimodal platform for nondestructive analysis of engineered vascular biomaterials
    NIH R01HL121068Sep 1, 2015 - May 31, 2020
    Role: Principal Investigator
    Fluorescence Lifetime Imaging/Spectroscopy System For Robotic Cancer Surgery Guidance
    NIH R01CA187427Sep 12, 2014 - Apr 30, 2026
    Role: Principal Investigator
    Fluorescence lifetime technique for detection of radiation necrosis vs gliom
    NIH R21CA178578Sep 1, 2014 - Aug 31, 2017
    Role: Principal Investigator
    Photodynamic Therapy Mediated by Cerenkov Light Emitted from Radiopharmaceut
    NIH R21EB018750May 1, 2014 - Apr 30, 2017
    Role: Principal Investigator
    Multi-modal high-resolution technology for tissue diagnostics
    NIH R21RR025818Sep 1, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Fluorescence lifetime method for guided therapy of brain tumors
    NIH R42CA117286Aug 1, 2006 - Jul 31, 2009
    Role: Principal Investigator
    MOEMS device for fluorescence spectroscopy of tissues and cells
    NIH R21EB003628Jul 1, 2005 - Dec 31, 2008
    Role: Principal Investigator
    Rupture prone plaque diagnosis by IVUS-guided time-resolved spectroscopy
    NIH R01HL067377Apr 15, 2001 - May 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Anatomy-Specific Classification Model Using Label-Free FLIm to Aid Intraoperative Surgical Guidance of Head and Neck Cancer. IEEE Trans Biomed Eng. 2023 10; 70(10):2863-2873. Hassan MA, Weyers BW, Bec J, Fereidouni F, Qi J, Gui D, Bewley AF, Abouyared M, Farwell DG, Birkeland AC, Marcu L. PMID: 37043314; PMCID: PMC10833893.
      View in: PubMed   Mentions:    Fields:    
    2. Pulse-sampling fluorescence lifetime imaging: evaluation of photon economy. Opt Lett. 2023 Sep 01; 48(17):4578-4581. Zhou X, Bec J, Ehrlich K, Garcia AA, Marcu L. PMID: 37656559; PMCID: PMC10883700.
      View in: PubMed   Mentions:    Fields:    
    3. Intraoperative molecular imaging: 3rd biennial clinical trials update. J Biomed Opt. 2023 05; 28(5):050901. Bou-Samra P, Muhammad N, Chang A, Karsalia R, Azari F, Kennedy G, Stummer W, Tanyi J, Martin L, Vahrmeijer A, Smith B, Rosenthal E, Wagner P, Rice D, Lee A, Abdelhafeez A, Malek MM, Kohanbash G, Barry Edwards W, Henderson E, Skjøth-Rasmussen J, Orosco R, Gibbs S, Farnam RW, Shankar L, Sumer B, Kumar ATN, Marcu L, Li L, Greuv V, Delikatny EJ, Lee JYK, Singhal S. PMID: 37193364; PMCID: PMC10182831.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    4. In vivo characterization of the human glioblastoma infiltrative edge with label-free intraoperative fluorescence lifetime imaging. Biomed Opt Express. 2023 May 01; 14(5):2196-2208. Alfonso-Garcia A, Anbunesan SN, Bec J, Lee HS, Jin LW, Bloch O, Marcu L. PMID: 37206147; PMCID: PMC10191664.
      View in: PubMed   Mentions: 1  
    5. Multimodal fluorescence lifetime imaging and optical coherence tomography for longitudinal monitoring of tissue-engineered cartilage maturation in a preclinical implantation model. J Biomed Opt. 2023 02; 28(2):026003. Zhou X, Haudenschild AK, Li C, Marcu L. PMID: 36818585; PMCID: PMC9932524.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Intraoperative detection of IDH-mutant glioma using fluorescence lifetime imaging. J Biophotonics. 2023 04; 16(4):e202200291. Noble Anbunesan S, Alfonso-Garcia A, Zhou X, Bec J, Lee HS, Jin LW, Bloch O, Marcu L. PMID: 36510639; PMCID: PMC10522274.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Non-destructive, continuous monitoring of biochemical, mechanical, and structural maturation in engineered tissue. Sci Rep. 2022 09 28; 12(1):16227. Haudenschild AK, Sherlock BE, Zhou X, Sheaff CS, Hu JC, Leach JK, Marcu L, Athanasiou KA. PMID: 36171228; PMCID: PMC9519952.
      View in: PubMed   Mentions:    Fields:    
    8. Dual-modality fluorescence lifetime imaging-optical coherence tomography intravascular catheter system with freeform catheter optics. J Biomed Opt. 2022 07; 27(7). Li C, Bec J, Zhou X, Marcu L. PMID: 35864574; PMCID: PMC9300477.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Engineering the gain and bandwidth in avalanche photodetectors. Opt Express. 2022 May 09; 30(10):16873-16882. Bartolo-Perez C, Ahamed A, Mayet AS, Rawat A, McPhillips L, Ghandiparsi S, Bec J, Ariño-Estrada G, Cherry S, Wang SY, Marcu L, Saif Islam M. PMID: 36221521; PMCID: PMC9363021.
      View in: PubMed   Mentions: 1     Fields:    
    10. Intraoperative delineation of p16+ oropharyngeal carcinoma of unknown primary origin with fluorescence lifetime imaging: Preliminary report. Head Neck. 2022 08; 44(8):1765-1776. Weyers BW, Birkeland AC, Marsden MA, Tam A, Bec J, Frusciante RP, Gui D, Bewley AF, Abouyared M, Marcu L, Farwell DG. PMID: 35511208; PMCID: PMC9979707.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Assessment of Murine Colon Inflammation Using Intraluminal Fluorescence Lifetime Imaging. Molecules. 2022 Feb 15; 27(4). Alfonso-Garcia A, Cevallos SA, Lee JY, Li C, Bec J, Bäumler AJ, Marcu L. PMID: 35209104; PMCID: PMC8875403.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    12. First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence. J Biomed Opt. 2022 02; 27(2). Alfonso-García A, Zhou X, Bec J, Anbunesan SN, Fereidouni F, Jin LW, Lee HS, Bloch O, Marcu L. PMID: 35112514; PMCID: PMC8809358.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Multimodal Scanning Microscope Combining Optical Coherence Tomography, Raman Spectroscopy and Fluorescence Lifetime Microscopy for Mesoscale Label-Free Imaging of Tissue. Anal Chem. 2021 08 24; 93(33):11479-11487. Vasquez D, Knorr F, Hoffmann F, Ernst G, Marcu L, Schmitt M, Guntinas-Lichius O, Popp J, Schie IW. PMID: 34380310.
      View in: PubMed   Mentions: 2     Fields:    
    14. Multispectral fluorescence lifetime imaging device with a silicon avalanche photodetector. Opt Express. 2021 Jun 21; 29(13):20105-20120. Zhou X, Bec J, Yankelevich D, Marcu L. PMID: 34266107; PMCID: PMC8237936.
      View in: PubMed   Mentions: 8     Fields:    
    15. Intraoperative Mapping of Parathyroid Glands Using Fluorescence Lifetime Imaging. J Surg Res. 2021 09; 265:42-48. Marsden M, Weaver SS, Marcu L, Campbell MJ. PMID: 33878575; PMCID: PMC8238823.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    16. Mesoscopic fluorescence lifetime imaging: Fundamental principles, clinical applications and future directions. J Biophotonics. 2021 06; 14(6):e202000472. Alfonso-Garcia A, Bec J, Weyers B, Marsden M, Zhou X, Li C, Marcu L. PMID: 33710785; PMCID: PMC8579869.
      View in: PubMed   Mentions: 15     Fields:    
    17. Intraoperative Margin Assessment in Oral and Oropharyngeal Cancer Using Label-Free Fluorescence Lifetime Imaging and Machine Learning. IEEE Trans Biomed Eng. 2021 03; 68(3):857-868. Marsden M, Weyers BW, Bec J, Sun T, Gandour-Edwards RF, Birkeland AC, Abouyared M, Bewley AF, Farwell DG, Marcu L. PMID: 32746066; PMCID: PMC8960054.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    18. Label-Free Visualization and Quantification of Biochemical Markers of Atherosclerotic Plaque Progression Using Intravascular Fluorescence Lifetime. JACC Cardiovasc Imaging. 2021 09; 14(9):1832-1842. Bec J, Vela D, Phipps JE, Agung M, Unger J, Margulies KB, Southard JA, Buja LM, Marcu L. PMID: 33221238; PMCID: PMC8116358.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    19. Physical, Biomechanical, and Optical Characterization of Collagen and Elastin Blend Hydrogels. Ann Biomed Eng. 2020 Dec; 48(12):2924-2935. Vazquez-Portalatin N, Alfonso-Garcia A, Liu JC, Marcu L, Panitch A. PMID: 32929559; PMCID: PMC7770626.
      View in: PubMed   Mentions: 9     Fields:    
    20. FLIm and Raman Spectroscopy for Investigating Biochemical Changes of Bovine Pericardium upon Genipin Cross-Linking. Molecules. 2020 Aug 25; 25(17). Shaik TA, Alfonso-Garcia A, Richter M, Korinth F, Krafft C, Marcu L, Popp J. PMID: 32854230; PMCID: PMC7503846.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    21. FLImBrush: dynamic visualization of intraoperative free-hand fiber-based fluorescence lifetime imaging. Biomed Opt Express. 2020 Sep 01; 11(9):5166-5180. Marsden M, Fukazawa T, Deng YC, Weyers BW, Bec J, Gregory Farwell D, Marcu L. PMID: 33014606; PMCID: PMC7510860.
      View in: PubMed   Mentions: 12  
    22. Investigating Origins of FLIm Contrast in Atherosclerotic Lesions Using Combined FLIm-Raman Spectroscopy. Front Cardiovasc Med. 2020; 7:122. Bec J, Shaik TA, Krafft C, Bocklitz TW, Alfonso-Garcia A, Margulies KB, Popp J, Marcu L. PMID: 32793637; PMCID: PMC7385056.
      View in: PubMed   Mentions: 5  
    23. FLIm-Guided Raman Imaging to Study Cross-Linking and Calcification of Bovine Pericardium. Anal Chem. 2020 08 04; 92(15):10659-10667. Shaik TA, Alfonso-García A, Zhou X, Arnold KM, Haudenschild AK, Krafft C, Griffiths LG, Popp J, Marcu L. PMID: 32598134; PMCID: PMC7539574.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    24. Real-time diagnosis and visualization of tumor margins in excised breast specimens using fluorescence lifetime imaging and machine learning. Biomed Opt Express. 2020 Mar 01; 11(3):1216-1230. Unger J, Hebisch C, Phipps JE, Lagarto JL, Kim H, Darrow MA, Bold RJ, Marcu L. PMID: 32206404; PMCID: PMC7075618.
      View in: PubMed   Mentions: 18  
    25. Bovine pericardial extracellular matrix niche modulates human aortic endothelial cell phenotype and function. Sci Rep. 2019 11 13; 9(1):16688. Shklover J, McMasters J, Alfonso-Garcia A, Higuita ML, Panitch A, Marcu L, Griffiths L. PMID: 31723198; PMCID: PMC6853938.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    26. Fluorescence lifetime imaging for intraoperative cancer delineation in transoral robotic surgery. Transl Biophotonics. 2019 Dec; 1(1-2). Weyers BW, Marsden M, Sun T, Bec J, Bewley AF, Gandour-Edwards RF, Moore MG, Farwell DG, Marcu L. PMID: 32656529; PMCID: PMC7351319.
      View in: PubMed   Mentions: 15  
    27. Broadband, freeform focusing micro-optics for a side-viewing imaging catheter. Opt Lett. 2019 Oct 15; 44(20):4961-4964. Bec J, Li C, Marcu L. PMID: 31613239; PMCID: PMC9010228.
      View in: PubMed   Mentions: 4     Fields:    
    28. Simultaneous intraluminal imaging of tissue autofluorescence and eGFP-labeled cells in engineered vascular grafts inside a bioreactor. Methods Appl Fluoresc. 2019 Sep 20; 7(4):044003. Li C, Alfonso-Garcia A, McMasters J, Bec J, Weyers B, Uyesaka L, Griffiths L, Panitch A, Marcu L. PMID: 31505471; PMCID: PMC7539617.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    29. Real-time augmented reality for delineation of surgical margins during neurosurgery using autofluorescence lifetime contrast. J Biophotonics. 2020 01; 13(1):e201900108. Alfonso-Garcia A, Bec J, Sridharan Weaver S, Hartl B, Unger J, Bobinski M, Lechpammer M, Girgis F, Boggan J, Marcu L. PMID: 31304655; PMCID: PMC7510838.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    30. Fiber-based platform for synchronous imaging of endogenous and exogenous fluorescence of biological tissue. Opt Lett. 2019 Jul 01; 44(13):3350-3353. Alfonso-Garcia A, Li C, Bec J, Yankelevich D, Marcu L, Sherlock B. PMID: 31259958; PMCID: PMC7539616.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    31. Multiscale, multispectral fluorescence lifetime imaging using a double-clad fiber. Opt Lett. 2019 May 01; 44(9):2302-2305. Sherlock BE, Li C, Zhou X, Alfonso-Garcia A, Bec J, Yankelevich D, Marcu L. PMID: 31042209; PMCID: PMC7539568.
      View in: PubMed   Mentions: 3     Fields:    
    32. Raman ChemLighter: Fiber optic Raman probe imaging in combination with augmented chemical reality. J Biophotonics. 2019 07; 12(7):e201800447. Yang W, Mondol AS, Stiebing C, Marcu L, Popp J, Schie IW. PMID: 30848073.
      View in: PubMed   Mentions: 4     Fields:    
    33. Multimodal Label-Free Imaging for Detecting Maturation of Engineered Osteogenic Grafts. ACS Biomater Sci Eng. 2019 Apr 08; 5(4):1956-1966. Harvestine JN, Sheaff CS, Li C, Haudenschild AK, Gionet-Gonzales MA, Hu JC, Athanasiou KA, Marcu L, Leach JK. PMID: 33405522; PMCID: PMC8594456.
      View in: PubMed   Mentions: 3     Fields:    
    34. Non-destructive detection of matrix stabilization correlates with enhanced mechanical properties of self-assembled articular cartilage. J Tissue Eng Regen Med. 2019 04; 13(4):637-648. Haudenschild AK, Sherlock BE, Zhou X, Hu JC, Leach JK, Marcu L, Athanasiou KA. PMID: 30770656; PMCID: PMC6461514.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    35. Autofluorescence lifetime augmented reality as a means for real-time robotic surgery guidance in human patients. Sci Rep. 2019 02 04; 9(1):1187. Gorpas D, Phipps J, Bec J, Ma D, Dochow S, Yankelevich D, Sorger J, Popp J, Bewley A, Gandour-Edwards R, Marcu L, Farwell DG. PMID: 30718542; PMCID: PMC6362025.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    36. Detection of glycosaminoglycan loss in articular cartilage by fluorescence lifetime imaging. J Biomed Opt. 2018 12; 23(12):1-8. Zhou X, Haudenschild AK, Sherlock BE, Hu JC, Leach JK, Athanasiou KA, Marcu L. PMID: 30578627; PMCID: PMC8357192.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    37. Label-free assessment of carotid artery biochemical composition using fiber-based fluorescence lifetime imaging. Biomed Opt Express. 2018 Sep 01; 9(9):4064-4076. Alfonso-Garcia A, Haudenschild AK, Marcu L. PMID: 30615748; PMCID: PMC6157793.
      View in: PubMed   Mentions: 10  
    38. Nondestructive fluorescence lifetime imaging and time-resolved fluorescence spectroscopy detect cartilage matrix depletion and correlate with mechanical properties. Eur Cell Mater. 2018 07 27; 36:30-43. Haudenschild AK, Sherlock BE, Zhou X, Hu JC, Leach JK, Marcu L, Athanasiou KA. PMID: 30051455.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    39. Label-Free Assessment of Collagenase Digestion on Bovine Pericardium Properties by Fluorescence Lifetime Imaging. Ann Biomed Eng. 2018 Nov; 46(11):1870-1881. Li C, Shklover J, Parvizi M, Sherlock BE, Alfonso Garcia A, Haudenschild AK, Griffiths LG, Marcu L. PMID: 30003502; PMCID: PMC7700017.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    40. Label-free fluorescence lifetime spectroscopy detects radiation-induced necrotic changes in live brain in real-time. Biomed Opt Express. 2018 Aug 01; 9(8):3559-3580. Hartl BA, Ma HSW, Sridharan S, Hansen KS, Kent MS, Gorin F, Fragoso RC, Marcu L. PMID: 30338140; PMCID: PMC6191615.
      View in: PubMed   Mentions: 4  
    41. Fiber-based fluorescence lifetime imaging of recellularization processes on vascular tissue constructs. J Biophotonics. 2018 09; 11(9):e201700391. Alfonso-Garcia A, Shklover J, Sherlock BE, Panitch A, Griffiths LG, Marcu L. PMID: 29781171; PMCID: PMC7700018.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    42. Electrocautery effects on fluorescence lifetime measurements: An in vivo study in the oral cavity. J Photochem Photobiol B. 2018 08; 185:90-99. Lagarto JL, Phipps JE, Faller L, Ma D, Unger J, Bec J, Griffey S, Sorger J, Farwell DG, Marcu L. PMID: 29883910; PMCID: PMC6629261.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    43. Nondestructive assessment of collagen hydrogel cross-linking using time-resolved autofluorescence imaging. J Biomed Opt. 2018 03; 23(3):1-9. Sherlock BE, Harvestine JN, Mitra D, Haudenschild A, Hu J, Athanasiou KA, Leach JK, Marcu L. PMID: 29512359; PMCID: PMC5839417.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    44. Time-resolved fluorescence spectroscopy for the diagnosis of oral lichen planus. Clin Exp Dermatol. 2018 Jul; 43(5):546-552. Gorpas D, Davari P, Bec J, Fung MA, Marcu L, Farwell DG, Fazel N. PMID: 29436013; PMCID: PMC9008188.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    45. Method for accurate registration of tissue autofluorescence imaging data with corresponding histology: a means for enhanced tumor margin assessment. J Biomed Opt. 2018 01; 23(1):1-11. Unger J, Sun T, Chen YL, Phipps JE, Bold RJ, Darrow MA, Ma KL, Marcu L. PMID: 29297208; PMCID: PMC5749583.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    46. Real-time Visualization of Tumor Margins in Breast Specimen using Fluorescence Lifetime Imaging. . 2018 Jan 1; ctu4b.4. Unger UJ, Hebisch HC, Phipps PJ, Darrow DM, Bold BR, Marcu ML. .
      View in: Publisher Site   Mentions:
    47. Head and Neck Cancer Evaluation via Transoral Robotic Surgery with Augmented Fluorescence Lifetime Imaging. . 2018 Jan 1; ctu2b.3. Phipps PJ, Unger UJ, Gandour-Edwards GR, Moore MM, Bewley BA, Farwell FD, Marcu ML. .
      View in: Publisher Site   Mentions:
    48. Label-free Fluorescence Lifetime Imaging for Assessment of Carotid Artery Grafts. . 2018 Jan 1; cw4b.4. Alfonso Garcia AA, Haudenschild HA, Marcu ML. .
      View in: Publisher Site   Mentions:
    49. Automated detection of breast cancer in resected specimens with fluorescence lifetime imaging. Phys Med Biol. 2017 12 14; 63(1):015003. Phipps JE, Gorpas D, Unger J, Darrow M, Bold RJ, Marcu L. PMID: 29099721; PMCID: PMC7485302.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    50. Biophotonics: the big picture. J Biomed Opt. 2017 12; 23(2):1-7. Marcu L, Boppart SA, Hutchinson MR, Popp J, Wilson BC. PMID: 29275543.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    51. Label-free optical imaging technologies for rapid translation and use during intraoperative surgical and tumor margin assessment. J Biomed Opt. 2017 12; 23(2):1-10. Boppart SA, Brown JQ, Farah CS, Kho E, Marcu L, Saunders CM, Sterenborg HJCM. PMID: 29288572; PMCID: PMC5747261.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    52. Simultaneous, label-free, multispectral fluorescence lifetime imaging and optical coherence tomography using a double-clad fiber. Opt Lett. 2017 Oct 01; 42(19):3753-3756. Sherlock BE, Phipps JE, Bec J, Marcu L. PMID: 28957119; PMCID: PMC8951707.
      View in: PubMed   Mentions: 21     Fields:    
    53. Rapid fluorescence lifetime estimation with modified phasor approach and Laguerre deconvolution: a comparative study. Methods Appl Fluoresc. 2017 09 01; 5(3):035003. Fereidouni F, Gorpas D, Ma D, Fatakdawala H, Marcu L. PMID: 28644150; PMCID: PMC6043162.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    54. Intravascular imaging for characterization of coronary atherosclerosis. Current Opinion in Biomedical Engineering. 2017 Sep 1; 3:1-12. van Soest vG, Marcu ML, Bouma BB, Regar RE. .
      View in: Publisher Site   Mentions:
    55. In vivo label-free structural and biochemical imaging of coronary arteries using an integrated ultrasound and multispectral fluorescence lifetime catheter system. Sci Rep. 2017 08 21; 7(1):8960. Bec J, Phipps JE, Gorpas D, Ma D, Fatakdawala H, Margulies KB, Southard JA, Marcu L. PMID: 28827758; PMCID: PMC5566546.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    56. In vivo Optical Imaging / Intravital Microscopy. J Biophotonics. 2017 06; 10(6-7):760-761. Marcu L, Hillman EMC. PMID: 28661586.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    57. The effect of radiation dose on the onset and progression of radiation-induced brain necrosis in the rat model. Int J Radiat Biol. 2017 07; 93(7):676-682. Hartl BA, Ma HSW, Hansen KS, Perks J, Kent MS, Fragoso RC, Marcu L. PMID: 28306402; PMCID: PMC5751742.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsPHPublic Health
    58. Reply to Comment: 'A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-square deconvolution with Laguerre expansion'. Phys Med Biol. 2017 02 21; 62(4):1637-1641. Ma D, Liu J, Qi J, Marcu L. PMID: 28145280; PMCID: PMC5340299.
      View in: PubMed   Mentions: 2     Fields:    
    59. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology. Eur Heart J. 2017 02 07; 38(6):400-412. Bourantas CV, Jaffer FA, Gijsen FJ, van Soest G, Madden SP, Courtney BK, Fard AM, Tenekecioglu E, Zeng Y, van der Steen AFW, Emelianov S, Muller J, Stone PH, Marcu L, Tearney GJ, Serruys PW. PMID: 27118197; PMCID: PMC5837589.
      View in: PubMed   Mentions: 65     Fields:    Translation:Humans
    60. Fluorescence Lifetime Imaging for Intra-Operative Guidance during Thyroid Surgery. . 2017 Jan 1; omm3d.2. Sridharan SS, Huang HE, Campbell CM, Marcu ML. .
      View in: Publisher Site   Mentions:
    61. Detection of Pentosidine Cross-Links in Cell-Secreted Decellularized Matrices Using Time Resolved Fluorescence Spectroscopy. ACS Biomater Sci Eng. 2017 Sep 11; 3(9):1944-1954. Mitra D, Fatakdawala H, Nguyen-Truong M, Creecy A, Nyman J, Marcu L, Leach JK. PMID: 28944287; PMCID: PMC5604893.
      View in: PubMed   Mentions: 9     Fields:    
    62. Online multispectral fluorescence lifetime values estimation and overlay onto tissue white-light video frames. Proceedings of SPIE. 2016 Apr 13; 9696:969609-969609-4. Gorpas GD, Ma MD, Bec BJ, Yankelevich YD, Marcu ML. .
      View in: Publisher Site   Mentions:
    63. Comparing Raman and fluorescence lifetime spectroscopy from human atherosclerotic lesions using a bimodal probe. J Biophotonics. 2016 09; 9(9):958-66. Dochow S, Fatakdawala H, Phipps JE, Ma D, Bocklitz T, Schmitt M, Bishop JW, Margulies KB, Marcu L, Popp J. PMID: 27003796; PMCID: PMC5012915.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    64. Real-Time Visualization of Tissue Surface Biochemical Features Derived From Fluorescence Lifetime Measurements. IEEE Trans Med Imaging. 2016 08; 35(8):1802-11. Gorpas D, Ma D, Bec J, Yankelevich DR, Marcu L. PMID: 26890641; PMCID: PMC5131727.
      View in: PubMed   Mentions: 27     Fields:    
    65. Fluorescence Lifetime Spectroscopy and Imaging Techniques in Medical Applications. . 2016 Jan 1; 3:1-46. Gorpas GD, Marcu ML. .
      View in: Publisher Site   Mentions:
    66. Activating Photodynamic Therapy in vitro with Cerenkov Radiation Generated from Yttrium-90. J Environ Pathol Toxicol Oncol. 2016; 35(2):185-92. Hartl BA, Hirschberg H, Marcu L, Cherry SR. PMID: 27481495; PMCID: PMC5332141.
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    67. Combined fiber probe for fluorescence lifetime and Raman spectroscopy. Anal Bioanal Chem. 2015 Nov; 407(27):8291-301. Dochow S, Ma D, Latka I, Bocklitz T, Hartl B, Bec J, Fatakdawala H, Marple E, Urmey K, Wachsmann-Hogiu S, Schmitt M, Marcu L, Popp J. PMID: 26093843; PMCID: PMC4995092.
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    68. Fluorescence Lifetime Imaging Combined with Conventional Intravascular Ultrasound for Enhanced Assessment of Atherosclerotic Plaques: an Ex Vivo Study in Human Coronary Arteries. J Cardiovasc Transl Res. 2015 Jun; 8(4):253-63. Fatakdawala H, Gorpas D, Bishop JW, Bec J, Ma D, Southard JA, Margulies KB, Marcu L. PMID: 25931307; PMCID: PMC4473095.
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    69. Fluorescence lifetime spectroscopy for breast cancer margins assessment. Proceedings of SPIE. 2015 Mar 12; 9318:93180b-93180b-5. Gorpas GD, Fatakdawala FH, Zhang ZY, Bold BR, Marcu ML. .
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    70. Multimodal imaging of vascular grafts using time-resolved fluorescence and ultrasound. Proceedings of SPIE. 2015 Feb 26; 9303:930335-930335-8. Fatakdawala FH, Griffiths GL, Wong WM, Julien JM, Marcu ML. .
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    71. In-vivo validation of fluorescence lifetime imaging (FLIm) of coronary arteries in swine. Proceedings of SPIE. 2015 Feb 26; 9303:93033m-93033m-5. Bec BJ, Ma MD, Yankelevich YD, Gorpas GD, Ferrier FW, Southard SJ, Marcu ML. .
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    72. Technique for real-time tissue characterization based on scanning multispectral fluorescence lifetime spectroscopy (ms-TRFS). Biomed Opt Express. 2015 Mar 01; 6(3):987-1002. Ma D, Bec J, Gorpas D, Yankelevich D, Marcu L. PMID: 25798320; PMCID: PMC4361450.
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    73. Characterizing low fluence thresholds for in vitro photodynamic therapy. Biomed Opt Express. 2015 Mar 01; 6(3):770-9. Hartl BA, Hirschberg H, Marcu L, Cherry SR. PMID: 25798302; PMCID: PMC4361432.
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    74. Fluorescence lifetime imaging and intravascular ultrasound: co-registration study using ex vivo human coronaries. IEEE Trans Med Imaging. 2015 Jan; 34(1):156-66. Gorpas D, Fatakdawala H, Bec J, Ma D, Yankelevich DR, Qi J, Marcu L. PMID: 25163056; PMCID: PMC4428614.
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    75. Time-resolved fluorescence spectroscopy and ultrasound backscatter microscopy for nondestructive evaluation of vascular grafts. J Biomed Opt. 2014 Aug; 19(8):080503. Fatakdawala H, Griffiths LG, Humphrey S, Marcu L. PMID: 25147960; PMCID: PMC4407666.
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    76. Computational analysis of the effectiveness of blood flushing with saline injection from an intravascular diagnostic catheter. Int J Numer Method Biomed Eng. 2014 Nov; 30(11):1278-93. Ghata N, Aldredge RC, Bec J, Marcu L. PMID: 24953876; PMCID: PMC4429308.
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    77. Rotational multispectral fluorescence lifetime imaging and intravascular ultrasound: bimodal system for intravascular applications. J Biomed Opt. 2014 Jun; 19(6):066004. Ma D, Bec J, Yankelevich DR, Gorpas D, Fatakdawala H, Marcu L. PMID: 24898604; PMCID: PMC4045254.
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    78. Ultra low fluence rate photodynamic therapy: simulation of light emitted by the Cerenkov effect. Proceedings of SPIE. 2014 Mar 20; 8928:89280f-89280f-11. Gonzales GJ, Wang WF, Zamora ZG, Trinidad TA, Marcu ML, Cherry CS, Hirschberg HH. .
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    79. Bi-modal imaging of atherosclerotic plaques: Automated method for co-registration between fluorescence lifetime imaging and intravascular ultrasound data. Proceedings of SPIE. 2014 Mar 4; 8926:892638-892638-8. Gorpas GD, Fatakdawala FH, Bec BJ, Ma MD, Yankelevich YD, Bishop BJ, Qi QJ, Marcu ML. .
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    80. Design and evaluation of a device for fast multispectral time-resolved fluorescence spectroscopy and imaging. Rev Sci Instrum. 2014 Mar; 85(3):034303. Yankelevich DR, Ma D, Liu J, Sun Y, Sun Y, Bec J, Elson DS, Marcu L. PMID: 24689603; PMCID: PMC3971822.
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    81. Development of a new pulsed source for photoacoustic imaging based on aperiodically poled lithium niobate. Biomed Opt Express. 2014 Feb 01; 5(2):468-73. Yankelevich D, González JE, Cudney RS, Ríos LA, Marcu L. PMID: 24575341; PMCID: PMC3920877.
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    82. Ultrasound backscatter microscopy for imaging of oral carcinoma. J Ultrasound Med. 2013 Oct; 32(10):1789-97. Lam M, Chaudhari AJ, Sun Y, Zhou F, Dobbie A, Gandour-Edwards RF, Tinling SP, Farwell DG, Monsky WL, Shung KK, Marcu L. PMID: 24065260; PMCID: PMC3835773.
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    83. Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques. Biomed Opt Express. 2013; 4(9):1724-41. Fatakdawala H, Poti S, Zhou F, Sun Y, Bec J, Liu J, Yankelevich DR, Tinling SP, Gandour-Edwards RF, Farwell DG, Marcu L. PMID: 24049693; PMCID: PMC3771843.
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    84. Endoscopic fluorescence lifetime imaging for in vivo intraoperative diagnosis of oral carcinoma. Microsc Microanal. 2013 Aug; 19(4):791-8. Sun Y, Phipps JE, Meier J, Hatami N, Poirier B, Elson DS, Farwell DG, Marcu L. PMID: 23702007; PMCID: PMC4128621.
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    85. Multispectral fluorescence lifetime imaging system for intravascular diagnostics with ultrasound guidance: in vivo validation in swine arteries. J Biophotonics. 2014 May; 7(5):281-5. Bec J, Ma DM, Yankelevich DR, Liu J, Ferrier WT, Southard J, Marcu L. PMID: 23495014; PMCID: PMC4410675.
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    86. In vivo validation of a bimodal technique combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy for diagnosis of oral carcinoma. J Biomed Opt. 2012 Nov; 17(11):116003. Sun Y, Xie H, Liu J, Lam M, Chaudhari AJ, Zhou F, Bec J, Yankelevich DR, Dobbie A, Tinling SL, Gandour-Edwards RF, Monsky WL, Farwell DG, Marcu L. PMID: 23117798; PMCID: PMC3484195.
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    87. Design, construction, and validation of a rotary multifunctional intravascular diagnostic catheter combining multispectral fluorescence lifetime imaging and intravascular ultrasound. J Biomed Opt. 2012 Oct; 17(10):106012. Bec J, Xie H, Yankelevich DR, Zhou F, Sun Y, Ghata N, Aldredge R, Marcu L. PMID: 23224011; PMCID: PMC3461057.
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    88. Pulse shape discrimination and classification methods for continuous depth of interaction encoding PET detectors. Phys Med Biol. 2012 Oct 21; 57(20):6571-85. Roncali E, Phipps JE, Marcu L, Cherry SR. PMID: 23010690; PMCID: PMC3482627.
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    89. A fluorescence lifetime imaging classification method to investigate the collagen to lipid ratio in fibrous caps of atherosclerotic plaque. Lasers Surg Med. 2012 Sep; 44(7):564-71. Phipps JE, Sun Y, Fishbein MC, Marcu L. PMID: 22886522; PMCID: PMC4083183.
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    90. Multispectral scanning time-resolved fluorescence spectroscopy (TRFS) technique for intravascular diagnosis. Biomed Opt Express. 2012 Jul 01; 3(7):1521-33. Xie H, Bec J, Liu J, Sun Y, Lam M, Yankelevich DR, Marcu L. PMID: 22808425; PMCID: PMC3395478.
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    91. A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-squares deconvolution with Laguerre expansion. Phys Med Biol. 2012 Feb 21; 57(4):843-65. Liu J, Sun Y, Qi J, Marcu L. PMID: 22290334; PMCID: PMC3407553.
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    92. Nondestructive evaluation of tissue engineered articular cartilage using time-resolved fluorescence spectroscopy and ultrasound backscatter microscopy. Tissue Eng Part C Methods. 2012 Mar; 18(3):215-26. Sun Y, Responte D, Xie H, Liu J, Fatakdawala H, Hu J, Athanasiou KA, Marcu L. PMID: 22010819; PMCID: PMC3285603.
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    93. Fluorescence lifetime techniques in medical applications. Ann Biomed Eng. 2012 Feb; 40(2):304-31. Marcu L. PMID: 22273730; PMCID: PMC3368954.
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    94. Fluorescence Lifetime Spectroscopy and Imaging in Neurosurgery. IEEE J Sel Top Quantum Electron. 2012 Jul-Aug; 18(4):1465-1477. Marcu L, Hartl BA. PMID: 28053498; PMCID: PMC5205025.
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    95. Two-photon excited fluorescence lifetime measurements through a double-clad photonic crystal fiber for tissue micro-endoscopy. J Biophotonics. 2012 Jan; 5(1):14-9. Knorr F, Yankelevich DR, Liu J, Wachsmann-Hogiu S, Marcu L. PMID: 22045513; PMCID: PMC4128622.
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    96. Fluorescence lifetime imaging for the characterization of the biochemical composition of atherosclerotic plaques. J Biomed Opt. 2011 Sep; 16(9):096018. Phipps J, Sun Y, Saroufeem R, Hatami N, Fishbein MC, Marcu L. PMID: 21950932; PMCID: PMC3189976.
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    97. Multimodal characterization of compositional, structural and functional features of human atherosclerotic plaques. Biomed Opt Express. 2011 Aug 01; 2(8):2288-98. Sun Y, Chaudhari AJ, Lam M, Xie H, Yankelevich DR, Phipps J, Liu J, Fishbein MC, Cannata JM, Shung KK, Marcu L. PMID: 21833365; PMCID: PMC3149526.
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    98. A fluorescence lifetime spectroscopy study of matrix metalloproteinases-2 and -9 in human atherosclerotic plaque. J Biophotonics. 2011 Sep; 4(9):650-8. Phipps JE, Hatami N, Galis ZS, Baker JD, Fishbein MC, Marcu L. PMID: 21770037; PMCID: PMC3239410.
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    99. Dynamic tissue analysis using time- and wavelength-resolved fluorescence spectroscopy for atherosclerosis diagnosis. Opt Express. 2011 Feb 28; 19(5):3890-901. Sun Y, Sun Y, Stephens D, Xie H, Phipps J, Saroufeem R, Southard J, Elson DS, Marcu L. PMID: 21369214; PMCID: PMC3368314.
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    100. Towards development of an intravascular diagnostic catheter based on fluorescence lifetime spectroscopy: study of an optimized blood flushing system. Proceedings of SPIE. 2011 Feb 10; 7883:78833e-78833e-13. Ghata GN, Aldredge AR, Bec BJ, Marcu ML. .
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    101. Design, construction, and validation of a multimodal intravascular diagnostic catheter combining IVUS and fluorescence lifetime spectroscopy detection channels. Proceedings of SPIE. 2011 Feb 10; 7883:788337-788337-6. Bec BJ, Xie XH, Yankelevich YD, Zhou ZF, Sun SY, Ghata GN, Aldredge AR, Marcu ML. .
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    102. Noninvasive multimodal evaluation of bioengineered cartilage constructs combining time-resolved fluorescence and ultrasound imaging. Tissue Eng Part C Methods. 2011 Apr; 17(4):495-504. Fite BZ, Decaris M, Sun Y, Sun Y, Lam A, Ho CK, Leach JK, Marcu L. PMID: 21303258; PMCID: PMC3065732.
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    103. Fluorescence Lifetime Spectroscopy in Cardioand Neuroimaging. . 2011 Jan 18; 255-285. Marcu ML, Jo JJ, Butte BP. .
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    104. Fluorescence lifetime spectroscopy for guided therapy of brain tumors. Neuroimage. 2011 Jan; 54 Suppl 1:S125-35. Butte PV, Mamelak AN, Nuno M, Bannykh SI, Black KL, Marcu L. PMID: 21055475; PMCID: PMC3335732.
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    105. Fluorescence lifetime imaging microscopy for brain tumor image-guided surgery. J Biomed Opt. 2010 Sep-Oct; 15(5):056022. Sun Y, Hatami N, Yee M, Phipps J, Elson DS, Gorin F, Schrot RJ, Marcu L. PMID: 21054116; PMCID: PMC2966493.
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    106. Time-resolved laser-induced fluorescence spectroscopy as a diagnostic instrument in head and neck carcinoma. Otolaryngol Head Neck Surg. 2010 Jun; 142(6):838-44. Meier JD, Xie H, Sun Y, Sun Y, Hatami N, Poirier B, Marcu L, Farwell DG. PMID: 20493355; PMCID: PMC3335733.
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    107. Intraoperative delineation of primary brain tumors using time-resolved fluorescence spectroscopy. J Biomed Opt. 2010 Mar-Apr; 15(2):027008. Butte PV, Fang Q, Jo JA, Yong WH, Pikul BK, Black KL, Marcu L. PMID: 20459282; PMCID: PMC4171753.
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    108. Endoscopic fluorescence lifetime imaging microscopy (FLIM) images of aortic plaque: an automated classification method. Proceedings of SPIE. 2010 Feb 11; 7548:754839-754839-5. Phipps PJ, Sun SY, Hatami HN, Fishbein FM, Rajaram RA, Saroufeem SR, Marcu ML. .
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    109. Time-resolved fluorescence spectroscopy as a diagnostic technique of oral carcinoma: Validation in the hamster buccal pouch model. Arch Otolaryngol Head Neck Surg. 2010 Feb; 136(2):126-33. Farwell DG, Meier JD, Park J, Sun Y, Coffman H, Poirier B, Phipps J, Tinling S, Enepekides DJ, Marcu L. PMID: 20157056; PMCID: PMC4128623.
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    110. Fluorescence lifetime in cardiovascular diagnostics. J Biomed Opt. 2010 Jan-Feb; 15(1):011106. Marcu L. PMID: 20210432; PMCID: PMC2847934.
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    111. Fluorescence lifetime imaging microscopy: in vivo application to diagnosis of oral carcinoma. Opt Lett. 2009 Jul 01; 34(13):2081-3. Sun Y, Phipps J, Elson DS, Stoy H, Tinling S, Meier J, Poirier B, Chuang FS, Farwell DG, Marcu L. PMID: 19572006; PMCID: PMC4083182.
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    112. Development of a dual-modal tissue diagnostic system combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy. Rev Sci Instrum. 2009 Jun; 80(6):065104. Sun Y, Park J, Stephens DN, Jo JA, Sun L, Cannata JM, Saroufeem RM, Shung KK, Marcu L. PMID: 19566223; PMCID: PMC2736572.
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    113. Intraluminal fluorescence spectroscopy catheter with ultrasound guidance. J Biomed Opt. 2009 May-Jun; 14(3):030505. Stephens DN, Park J, Sun Y, Papaioannou T, Marcu L. PMID: 19566287; PMCID: PMC4083184.
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    114. Performance of a diaphragmed microlens for a packaged microspectrometer. Sensors (Basel). 2009; 9(2):859-68. Lo J, Chen SJ, Fang Q, Papaioannou T, Kim ES, Gundersen M, Marcu L. PMID: 22399943; PMCID: PMC3280835.
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    115. Enzyme-containing hydrogel micropatterns serving a dual purpose of cell sequestration and metabolite detection. Biosens Bioelectron. 2009 Apr 15; 24(8):2604-10. Yan J, Sun Y, Zhu H, Marcu L, Revzin A. PMID: 19251408; PMCID: PMC2663022.
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    116. Fluorescence lifetime imaging microscopy for the characterization of atherosclerotic plaques. Proc SPIE Int Soc Opt Eng. 2009; 7161:71612G. Phipps J, Sun Y, Saroufeem R, Hatami N, Marcu L. PMID: 19606277; PMCID: PMC2709872.
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    117. A novel noninvasive all optical technique to monitor physiology of an exercising muscle. Phys Med Biol. 2008 Nov 07; 53(21):6211-25. Saxena V, Marcu L, Karunasiri G. PMID: 18854609.
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    118. Detection of rupture-prone atherosclerotic plaques by time-resolved laser-induced fluorescence spectroscopy. Atherosclerosis. 2009 May; 204(1):156-64. Marcu L, Jo JA, Fang Q, Papaioannou T, Reil T, Qiao JH, Baker JD, Freischlag JA, Fishbein MC. PMID: 18926540; PMCID: PMC2766393.
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    119. Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis. Opt Lett. 2008 Mar 15; 33(6):630-2. Sun Y, Liu R, Elson DS, Hollars CW, Jo JA, Park J, Sun Y, Marcu L. PMID: 18347733; PMCID: PMC10522294.
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    120. Novel tissue phantom for testing a dual-modality diagnostic system: time-resolved fluorescence spectroscopy and high frequency ultrasound. Proceedings of SPIE. 2008 Feb 7; 6870:68700d-68700d-9. Sun SY, Liao LK, Sun SY, Park PJ, Marcu ML. .
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    121. Percutaneous fiber-optic sensor for chronic glucose monitoring in vivo. Biosens Bioelectron. 2008 May 15; 23(10):1458-65. Liao KC, Hogen-Esch T, Richmond FJ, Marcu L, Clifton W, Loeb GE. PMID: 18304798.
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    122. Development of a Multi-modal Tissue Diagnostic System Combining High Frequency Ultrasound and Photoacoustic Imaging with Lifetime Fluorescence Spectroscopy. Proc IEEE Ultrason Symp. 2008; 570-573. Sun Y, Stephens DN, Park J, Sun Y, Marcu L, Cannata JM, Shung KK. PMID: 21894259; PMCID: PMC3164263.
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    123. In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies. Int J Cancer. 2007 Aug 01; 121(3):675-82. Garon EB, Sawcer D, Vernier PT, Tang T, Sun Y, Marcu L, Gundersen MA, Koeffler HP. PMID: 17417774.
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    124. Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis. J Biomed Opt. 2007 Jul-Aug; 12(4):044021. Wang J, Yong WH, Sun Y, Vernier PT, Koeffler HP, Gundersen MA, Marcu L. PMID: 17867825.
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    125. New methods for time-resolved fluorescence spectroscopy data analysis based on the Laguerre expansion technique--applications in tissue diagnosis. Methods Inf Med. 2007; 46(2):206-11. Jo JA, Marcu L, Fang Q, Papaioannou T, Qiao JH, Fishbein MC, Beseth B, Dorafshar AH, Reil T, Baker D, Freischlag J. PMID: 17347757.
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    126. MULTI-CANTILEVER-DRIVEN ROTATIONAL MICROGRATING FOR MOEMS SPECTROMETER. . 2007 Jan 1; 2421-2424. Lo LJ, Chen CS, Yu YH, Chi CD, Lee LC, Marcu ML, Kim KE, Gundersen GM. .
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    127. Quantum dot labeling and tracking of human leukemic, bone marrow and cord blood cells. Leuk Res. 2007 May; 31(5):643-51. Garon EB, Marcu L, Luong Q, Tcherniantchouk O, Crooks GM, Koeffler HP. PMID: 17027955; PMCID: PMC8761484.
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    128. Distinction of brain tissue, low grade and high grade glioma with time-resolved fluorescence spectroscopy. Front Biosci. 2006 May 01; 11:1255-63. Yong WH, Butte PV, Pikul BK, Jo JA, Fang Q, Papaioannou T, Black K, Marcu L. PMID: 16368511; PMCID: PMC2991156.
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    129. Fluorescence microscopy imaging of electroperturbation in mammalian cells. J Biomed Opt. 2006 Mar-Apr; 11(2):024010. Sun Y, Vernier PT, Behrend M, Wang J, Thu MM, Gundersen M, Marcu L. PMID: 16674200.
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    130. Laguerre-based method for analysis of time-resolved fluorescence data: application to in-vivo characterization and diagnosis of atherosclerotic lesions. J Biomed Opt. 2006 Mar-Apr; 11(2):021004. Jo JA, Fang Q, Papaioannou T, Baker JD, Dorafshar AH, Reil T, Qiao JH, Fishbein MC, Freischlag JA, Marcu L. PMID: 16674179; PMCID: PMC2672104.
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    131. Design and fabrication of a disposable, percutaneous glucose sensor. Proceedings of SPIE. 2006 Feb 9; 6083:60830v-60830v-9. Liao LK, Hogen-Esch HT, Richmond RF, Marcu ML, Clifton CW, Loeb LG. .
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    133. Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:2663-6. Jo JA, Fang Q, Papaioannou T, Qiao JH, Fishbein MC, Beseth B, Dorafshar AH, Reil T, Baker D, Freischlag J, Shung KK, Sun L, Marcu L. PMID: 17946129.
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    134. Electrode microchamber for noninvasive perturbation of mammalian cells with nanosecond pulsed electric fields. IEEE Trans Nanobioscience. 2005 Dec; 4(4):277-83. Sun Y, Vernier PT, Behrend M, Marcu L, Gundersen MA. PMID: 16433293.
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    135. Diagnosis of meningioma by time-resolved fluorescence spectroscopy. J Biomed Opt. 2005 Nov-Dec; 10(6):064026. Butte PV, Pikul BK, Hever A, Yong WH, Black KL, Marcu L. PMID: 16409091; PMCID: PMC2981341.
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    136. Oxidized-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine induces vascular endothelial superoxide production: implication of NADPH oxidase. Free Radic Biol Med. 2005 Dec 01; 39(11):1512-22. Rouhanizadeh M, Hwang J, Clempus RE, Marcu L, Lassègue B, Sevanian A, Hsiai TK. PMID: 16274886; PMCID: PMC2672101.
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    137. In vivo detection of macrophages in a rabbit atherosclerotic model by time-resolved laser-induced fluorescence spectroscopy. Atherosclerosis. 2005 Aug; 181(2):295-303. Marcu L, Fang Q, Jo JA, Papaioannou T, Dorafshar A, Reil T, Qiao JH, Baker JD, Freischlag JA, Fishbein MC. PMID: 16039283; PMCID: PMC2672099.
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    138. A nonparametric method for analysis of fluorescence emission in combined time and wavelength dimensions. Ann Biomed Eng. 2005 Apr; 33(4):531-44. Ivanova OV, Marcu L, Khoo MC. PMID: 15909659; PMCID: PMC2672102.
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    139. Piezoelectric optical MEMS scanning fluorescence biosensor. Proceedings of SPIE. 2005 Apr 1; 5692:103-110. Lo LJ, Kim KE, Gundersen GM, Marcu ML. .
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    140. A fluorescence microscopy study of quantum dots as fluorescent probes for brain tumor diagnosis. Proceedings of SPIE. 2005 Mar 31; 5703:127-134. Wang WJ, Vernier VP, Sun SY, Gundersen GM, Marcu ML. .
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    141. Picosecond fluorescence lifetime imaging microscope for imaging of living glioma cells. Proceedings of SPIE. 2005 Mar 29; 5699:33-39. Fang FQ, Wang WJ, Sun SY, Vernier VT, Papaioannou PT, Jo JJ, Thu TM, Gundersen GM, Marcu ML. .
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    142. Design and fabrication of disposable percutaneous chemical sensors. Proceedings of SPIE. 2005 Mar 23; 5691:129-145. Liao LK, Hogen-Esch HT, Richmond RF, Marcu ML, Loeb LG. .
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    143. Nanoelectropulse intracellular perturbation and electropermeabilization technology: phospholipid translocation, calcium bursts, chromatin rearrangement, cardiomyocyte activation, and tumor cell sensitivity. Conf Proc IEEE Eng Med Biol Soc. 2005; 2005:5850-3. Vernier PT, Sun Y, Wang J, Thu MM, Garon E, Valderrabano M, Marcu L, Koeffler HP, Gundersen MA. PMID: 17281590.
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    144. Ultrafast Method for the Analysis of Fluorescence Lifetime Imaging Microscopy Data Based on the Laguerre Expansion Technique. IEEE J Quantum Electron. 2005; 11(4):835-845. Jo JA, Fang Q, Marcu L. PMID: 19444338; PMCID: PMC2681327.
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    145. Nanosecond pulsed electric fields perturb membrane phospholipids in T lymphoblasts. FEBS Lett. 2004 Aug 13; 572(1-3):103-8. Vernier PT, Sun Y, Marcu L, Craft CM, Gundersen MA. PMID: 15304332.
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    146. Nanosecond Electroperturbation—Mammalian Cell Sensitivity and Bacterial Spore Resistance. IEEE Transactions on Plasma Science. 2004 Aug 1; 32(4):1620-1625. Vernier VP, Thu TM, Marcu ML, Craft CC, Gundersen GM. .
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    147. Validation of a time-resolved fluorescence spectroscopy apparatus in a rabbit atherosclerosis model. Proceedings of SPIE. 2004 Jul 13; 5312:294-299. Fang FQ, Jo JJ, Papaioannou PT, Dorafshar DA, Reil RT, Qiao QJ, Fishbein FM, Freischlag FJ, Marcu ML. .
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    148. Laguerre nonparametric deconvolution technique of time-resolved fluorescence data: application to the prediction of concentrations in a mixture of biochemical components. Proceedings of SPIE. 2004 Jul 13; 5326:8-16. Jo JJ, Fang FQ, Papaioannou PT, Marcu ML. .
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    149. Fluorescence lifetime spectroscopy of glioblastoma multiforme. Photochem Photobiol. 2004 Jul-Aug; 80:98-103. Marcu L, Jo JA, Butte PV, Yong WH, Pikul BK, Black KL, Thompson RC. PMID: 15339216.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    150. Fast model-free deconvolution of fluorescence decay for analysis of biological systems. J Biomed Opt. 2004 Jul-Aug; 9(4):743-52. Jo JA, Fang Q, Papaioannou T, Marcu L. PMID: 15250761; PMCID: PMC8527862.
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    151. Nanoelectropulse-induced phosphatidylserine translocation. Biophys J. 2004 Jun; 86(6):4040-8. Vernier PT, Sun Y, Marcu L, Craft CM, Gundersen MA. PMID: 15189899; PMCID: PMC1304304.
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    152. Effects of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media: an experimental and computational study at 337 nm. Appl Opt. 2004 May 10; 43(14):2846-60. Papaioannou T, Preyer NW, Fang Q, Brightwell A, Carnohan M, Cottone G, Ross R, Jones LR, Marcu L. PMID: 15143808; PMCID: PMC8527863.
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    153. Noninvasive in situ evaluation of osteogenic differentiation by time-resolved laser-induced fluorescence spectroscopy. Tissue Eng. 2004 Mar-Apr; 10(3-4):411-20. Ashjian P, Elbarbary A, Zuk P, DeUgarte DA, Benhaim P, Marcu L, Hedrick MH. PMID: 15165458; PMCID: PMC10522275.
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    154. Senciltrade mark project: development of a percutaneous optical biosensor. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:2082-5. Chih Liao K, Richmond F, Hogen-Esch T, Marcu L, Loeb GE. PMID: 17272132.
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    155. Time-domain laser-induced fluorescence spectroscopy apparatus for clinical diagnostics. Rev Sci Instrum. 2004 Jan; 75(1):151-162. Fang Q, Papaioannou T, Jo JA, Vaitha R, Shastry K, Marcu L. PMID: 35291695; PMCID: PMC8920500.
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    156. Calcium bursts induced by nanosecond electric pulses. Biochem Biophys Res Commun. 2003 Oct 17; 310(2):286-95. Vernier PT, Sun Y, Marcu L, Salemi S, Craft CM, Gundersen MA. PMID: 14521908.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    157. Effects of tissue optical properties on time-resolved fluorescence measurements from brain tumors: an experimental and computational study. Proceedings of SPIE. 2003 Jul 30; 4955:600-608. Butte BP, Vishwanath VK, Pikul PB, Mycek MM, Marcu ML. .
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    158. Estimation of optical fluorescent impulse response kernel in combined time and wavelength spaces. Proceedings of SPIE. 2003 Jul 30; 4955:330-341. Ivanova IO, Marcu ML, Khoo KM. .
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    159. Lifetime fluorescence spectroscopy for in situ investigation of osteogenic differentiation. Proceedings of SPIE. 2003 Jul 23; 4961:250-257. Marcu ML, Elbarbary EA, Zuk ZP, De Ugarte DD, Benhaim BP, Kurt KH, Hedrick HM, Ashjian AP. .
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    160. Performance evaluation of fiber optic probes for tissue lifetime fluorescence spectroscopy. Proceedings of SPIE. 2003 Jul 22; 4958:43-50. Papaioannou PT, Preyer PN, Fang FQ, Kurt KH, Carnohan CM, Ross RR, Brightwell BA, Cottone CG, Jones JL, Marcu ML. .
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    161. Compact time-resolved laser-induced fluorescence spectroscopic system for clinical investigations of diseased tissues. Proceedings of SPIE. 2003 Jul 22; 4958:60-66. Fang FQ, Papaioannou PT, Jo JJ, Vaitha VR, Shastry SK, Marcu ML. .
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    162. Detection of experimental brain tumors using time-resolved laser-induced fluorescence spectroscopy. Proceedings of SPIE. 2002 May 7; 4613:8-12. Thompson TR, Black BK, Kateb KB, Marcu ML. .
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    163. Time-resolved fluorescence spectroscopy of human brain tumors. Proceedings of SPIE. 2002 May 7; 4613:183-187. Marcu ML, Thompson TR, Garde GS, Sedrak SM, Black BK, Yong YW. .
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    164. Discrimination of human coronary artery atherosclerotic lipid-rich lesions by time-resolved laser-induced fluorescence spectroscopy. Arterioscler Thromb Vasc Biol. 2001 Jul; 21(7):1244-50. Marcu L, Fishbein MC, Maarek JM, Grundfest WS. PMID: 11451759.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    165. Arterial fluorescent components involved in atherosclerotic plaque instability: differentiation by time-resolved fluorescence spectroscopy. Proceedings of SPIE. 2001 May 21; 4244:428-433. Marcu ML, Grundfest GW, Maarek MJ. .
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    166. Time-resolved fluorescence spectra of arterial fluorescent compounds: reconstruction with the Laguerre expansion technique. Photochem Photobiol. 2000 Feb; 71(2):178-87. Maarek JM, Marcu L, Snyder WJ, Grundfest WS. PMID: 10687392.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    167. Time-resolved fluorescence of human aortic wall: use for improved identification of atherosclerotic lesions. Lasers Surg Med. 2000; 27(3):241-54. Maarek JM, Marcu L, Fishbein MC, Grundfest WS. PMID: 11013386.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    168. Photobleaching of arterial fluorescent compounds: characterization of elastin, collagen and cholesterol time-resolved spectra during prolonged ultraviolet irradiation. Photochem Photobiol. 1999 Jun; 69(6):713-21. Marcu L, Grundfest WS, Maarek JM. PMID: 10378012.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    169. Characterization of atherosclerotic lesions with laser-induced time-resolved fluorescence spectroscopy. Proceedings of SPIE. 1998 Apr 16; 3250:181-187. Maarek MJ, Marcu ML, Grundfest GW. .
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    170. Time-resolved laser-induced fluorescence of lipids involved in development of atherosclerotic lesion lipid-rich core. Proceedings of SPIE. 1998 Apr 16; 3250:158-167. Marcu ML, Maarek MJ, Grundfest GW. .
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    171. Near-infrared monitoring of hemoglobin content in the kidney during ischemia. Proceedings of SPIE. 1995 Apr 12; 2387:232-238. Snyder SW, Maarek MJ, Vari VS, Marcu ML, Papaioannou PT, Pergadia PV, Grundfest GW. .
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    172. Near-infrared monitoring of perfusion and oxygen availability in abdominal organs and skeletal muscle during hypoxia. Proceedings of SPIE. 1994 May 19; 2135:157-165. Maarek MJ, Vari VS, Marcu ML, Papaioannou PT, Pergadia PV, Snyder SW, Grundfest GW. .
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