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Fredric Austin Gorin

TitleDEPARTMENT CHAIR
InstitutionUniversity of California Davis
DepartmentMED: NEUROLOGY
Address4860 Y St. Suite 3700
CA 95817
Phone916-734-6284
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    Collapse Research 
    Collapse Research Activities and Funding
    Novel Glioma uPA Inhibitor Design Guided by Intracellular signaling Pathways
    NIH/NINDS R01NS060880Sep 1, 2009 - Jan 31, 2012
    Role: Principal Investigator
    Novel Amiloride Conjugates Selectively Kill Gliomas
    NIH/NINDS R01NS040489Jun 1, 2001 - Mar 31, 2010
    Role: Principal Investigator
    BRAIN GLYCOGEN PHOSPHORYLASE IN HYPOXIC-ISCHEMIC EVENTS
    NIH/NINDS R01NS023644Sep 1, 1985 - Aug 31, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tang T, Valenzuela A, Petit F, Chow S, Leung K, Gorin F, Louie AY, Dhenain M. In Vivo MRI of Functionalized Iron Oxide Nanoparticles for Brain Inflammation. Contrast Media Mol Imaging. 2018; 2018:3476476. PMID: 30079001.
      View in: PubMed
    2. Gorin F, Pasupuleti N, Mahajan D, Dugar S. Killing Glioma 'Stem-like' Cells via Drug-Induced Relocation of Endosomal Urokinase Proteins. Anticancer Agents Med Chem. 2017; 17(1):40-47. PMID: 27357540.
      View in: PubMed
    3. Pasupuleti N, Grodzki AC, Gorin F. Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death. Mol Pharmacol. 2015 Apr; 87(4):683-96. PMID: 25634671; PMCID: PMC4366798.
    4. Grodzki AC, Poola B, Pasupuleti N, Nantz MH, Lein PJ, Gorin F. A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor a and interleukin-1ß expression. J Pharmacol Exp Ther. 2015 Mar; 352(3):438-47. PMID: 25538105; PMCID: PMC4352593.
    5. Andreozzi E, Wang P, Valenzuela A, Tu C, Gorin F, Dhenain M, Louie A. Size-stable solid lipid nanoparticles loaded with Gd-DOTA for magnetic resonance imaging. Bioconjug Chem. 2013 Sep 18; 24(9):1455-67. PMID: 24004269.
      View in: PubMed
    6. Leon LJ, Pasupuleti N, Gorin F, Carraway KL. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013; 8(4):e63038. PMID: 23646172; PMCID: PMC3639988.
    7. Pasupuleti N, Leon L, Carraway KL, Gorin F. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013 Mar; 344(3):600-15. PMID: 23241369; PMCID: PMC3583503.
    8. Massey AP, Harley WR, Pasupuleti N, Gorin F, Nantz MH. 2-Amidino analogs of glycine-amiloride conjugates: inhibitors of urokinase-type plasminogen activator. Bioorg Med Chem Lett. 2012 Apr 01; 22(7):2635-9. PMID: 22366654; PMCID: PMC3329872.
    9. Harley W, Floyd C, Dunn T, Zhang XD, Chen TY, Hegde M, Palandoken H, Nantz MH, Leon L, Carraway KL, Lyeth B, Gorin F. Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas. Brain Res. 2010 Dec 02; 1363:159-69. PMID: 20869350; PMCID: PMC2996276.
    10. Sun Y, Hatami N, Yee M, Phipps J, Elson DS, Gorin F, Schrot RJ, Marcu L. Fluorescence lifetime imaging microscopy for brain tumor image-guided surgery. J Biomed Opt. 2010 Sep-Oct; 15(5):056022. PMID: 21054116; PMCID: PMC2966493.
    11. Zhao X, Gorin F, Berman RF, Lyeth BG. Differential hippocampal protection when blocking intracellular sodium and calcium entry during traumatic brain injury in rats. J Neurotrauma. 2008 Oct; 25(10):1195-205. PMID: 18847376; PMCID: PMC2652584.
    12. Schnier JB, Nishi K, Harley WR, Gorin F. An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas. J Neurooncol. 2008 Aug; 89(1):19-26. PMID: 18404250; PMCID: PMC2996278.
    13. Floyd CL, Gorin F, Lyeth BG. Mechanical strain injury increases intracellular sodium and reverses Na+/Ca2+ exchange in cortical astrocytes. Glia. 2005 Jul; 51(1):35-46. PMID: 15779085; PMCID: PMC2996279.
    14. Palandoken H, By K, Hegde M, Harley WR, Gorin F, Nantz MH. Amiloride peptide conjugates: prodrugs for sodium-proton exchange inhibition. J Pharmacol Exp Ther. 2005 Mar; 312(3):961-7. PMID: 15509720.
      View in: PubMed
    15. Hegde M, Roscoe J, Cala P, Gorin F. Amiloride kills malignant glioma cells independent of its inhibition of the sodium-hydrogen exchanger. J Pharmacol Exp Ther. 2004 Jul; 310(1):67-74. PMID: 15010500.
      View in: PubMed
    16. Gorin F, Harley W, Schnier J, Lyeth B, Jue T. Perinecrotic glioma proliferation and metabolic profile within an intracerebral tumor xenograft. Acta Neuropathol. 2004 Mar; 107(3):235-44. PMID: 14712400.
      View in: PubMed
    17. Schnier JB, Nishi K, Monks A, Gorin F, Bradbury EM. Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression. Biochem Biophys Res Commun. 2003 Sep 12; 309(1):126-34. PMID: 12943673.
      View in: PubMed
    18. Srinivas PR, Gusfield D, Mason O, Gertz M, Hogarth M, Stone J, Jones EG, Gorin F. Neuroanatomical term generation and comparison between two terminologies. Neuroinformatics. 2003; 1(2):177-92. PMID: 15046240.
      View in: PubMed
    19. Hogarth MA, Gertz M, Gorin F. jTerm: an open source terminology server. AMIA Annu Symp Proc. 2003; 861. PMID: 14728366; PMCID: PMC1480285.
    20. Gorin F, Hogarth M, Gertz M. The challenges and rewards of integrating diverse neuroscience information. Neuroscientist. 2001 Feb; 7(1):18-27. PMID: 11486341.
      View in: PubMed