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Fredric A Gorin

Title(s)Professor, Neurology
SchoolUniversity of California, Davis
Phone916-734-6284
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    Collapse Research 
    Collapse Research Activities and Funding
    Novel Glioma uPA Inhibitor Design Guided by Intracellular signaling Pathways
    NIH/NINDS R01NS060880Sep 1, 2009 - Jan 31, 2012
    Role: Principal Investigator
    Novel Amiloride Conjugates Selectively Kill Gliomas
    NIH/NINDS R01NS040489Jun 1, 2001 - Mar 31, 2010
    Role: Principal Investigator
    BRAIN GLYCOGEN PHOSPHORYLASE IN HYPOXIC-ISCHEMIC EVENTS
    NIH/NINDS R01NS023644Sep 1, 1985 - Aug 31, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hartl BA, Ma HSW, Sridharan S, Hansen KS, Kent MS, Gorin F, Fragoso RC, Marcu L. Label-free fluorescence lifetime spectroscopy detects radiation-induced necrotic changes in live brain in real-time. Biomed Opt Express. 2018 Aug 01; 9(8):3559-3580. PMID: 30338140.
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    2. Tang T, Valenzuela A, Petit F, Chow S, Leung K, Gorin F, Louie AY, Dhenain M. In Vivo MRI of Functionalized Iron Oxide Nanoparticles for Brain Inflammation. Contrast Media Mol Imaging. 2018; 2018:3476476. PMID: 30079001.
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    3. Gorin FA, Pasupuleti N, Mahajan D, Dugar S. Killing Glioma 'Stem-like' Cells via Drug-Induced Relocation of Endosomal Urokinase Proteins. Anticancer Agents Med Chem. 2017; 17(1):40-47. PMID: 27357540.
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    4. Pasupuleti N, Grodzki AC, Gorin F. Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death. Mol Pharmacol. 2015 Apr; 87(4):683-96. PMID: 25634671.
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    5. Grodzki AC, Poola B, Pasupuleti N, Nantz MH, Lein PJ, Gorin F. A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor a and interleukin-1ß expression. J Pharmacol Exp Ther. 2015 Mar; 352(3):438-47. PMID: 25538105.
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    6. Andreozzi E, Wang P, Valenzuela A, Tu C, Gorin F, Dhenain M, Louie A. Size-stable solid lipid nanoparticles loaded with Gd-DOTA for magnetic resonance imaging. Bioconjug Chem. 2013 Sep 18; 24(9):1455-67. PMID: 24004269.
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    7. Leon LJ, Pasupuleti N, Gorin F, Carraway KL. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013; 8(4):e63038. PMID: 23646172.
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    8. Pasupuleti N, Leon L, Carraway KL, Gorin F. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013 Mar; 344(3):600-15. PMID: 23241369.
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    9. Massey AP, Harley WR, Pasupuleti N, Gorin FA, Nantz MH. 2-Amidino analogs of glycine-amiloride conjugates: inhibitors of urokinase-type plasminogen activator. Bioorg Med Chem Lett. 2012 Apr 01; 22(7):2635-9. PMID: 22366654.
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    10. Harley W, Floyd C, Dunn T, Zhang XD, Chen TY, Hegde M, Palandoken H, Nantz MH, Leon L, Carraway KL, Lyeth B, Gorin FA. Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas. Brain Res. 2010 Dec 02; 1363:159-69. PMID: 20869350.
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    11. Sun Y, Hatami N, Yee M, Phipps J, Elson DS, Gorin F, Schrot RJ, Marcu L. Fluorescence lifetime imaging microscopy for brain tumor image-guided surgery. J Biomed Opt. 2010 Sep-Oct; 15(5):056022. PMID: 21054116.
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    12. Zhao X, Gorin FA, Berman RF, Lyeth BG. Differential hippocampal protection when blocking intracellular sodium and calcium entry during traumatic brain injury in rats. J Neurotrauma. 2008 Oct; 25(10):1195-205. PMID: 18847376.
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    13. Schnier JB, Nishi K, Harley WR, Gorin FA. An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas. J Neurooncol. 2008 Aug; 89(1):19-26. PMID: 18404250.
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    14. Vali S, Mythri RB, Jagatha B, Padiadpu J, Ramanujan KS, Andersen JK, Gorin F, Bharath MM. Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson's disease: a dynamic model. Neuroscience. 2007 Nov 23; 149(4):917-30. PMID: 17936517.
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    15. Kaushik P, Gorin F, Vali S. Dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis. J Comput Neurosci. 2007 Apr; 22(2):147-60. PMID: 17053993.
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    16. Raichur A, Vali S, Gorin F. Dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of Parkinson's disease. Neuroscience. 2006 Oct 27; 142(3):859-70. PMID: 16920272.
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    17. Floyd CL, Gorin FA, Lyeth BG. Mechanical strain injury increases intracellular sodium and reverses Na+/Ca2+ exchange in cortical astrocytes. Glia. 2005 Jul; 51(1):35-46. PMID: 15779085.
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    18. Schnier JB, Nishi K, Gumerlock PH, Gorin FA, Bradbury EM. Glycogen synthesis correlates with androgen-dependent growth arrest in prostate cancer. BMC Urol. 2005 Mar 24; 5:6. PMID: 15790394.
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    19. Srinivas PR, Wei SH, Cristianini N, Jones EG, Gorin FA. Comparison of vector space model methodologies to reconcile cross-species neuroanatomical concepts. Neuroinformatics. 2005; 3(2):115-31. PMID: 15988041.
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    20. Palandoken H, By K, Hegde M, Harley WR, Gorin FA, Nantz MH. Amiloride peptide conjugates: prodrugs for sodium-proton exchange inhibition. J Pharmacol Exp Ther. 2005 Mar; 312(3):961-7. PMID: 15509720.
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    21. Hegde M, Roscoe J, Cala P, Gorin F. Amiloride kills malignant glioma cells independent of its inhibition of the sodium-hydrogen exchanger. J Pharmacol Exp Ther. 2004 Jul; 310(1):67-74. PMID: 15010500.
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    22. Gorin F, Harley W, Schnier J, Lyeth B, Jue T. Perinecrotic glioma proliferation and metabolic profile within an intracerebral tumor xenograft. Acta Neuropathol. 2004 Mar; 107(3):235-44. PMID: 14712400.
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    23. Schnier JB, Nishi K, Monks A, Gorin FA, Bradbury EM. Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression. Biochem Biophys Res Commun. 2003 Sep 12; 309(1):126-34. PMID: 12943673.
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    24. Srinivas PR, Gusfield D, Mason O, Gertz M, Hogarth M, Stone J, Jones EG, Gorin FA. Neuroanatomical term generation and comparison between two terminologies. Neuroinformatics. 2003; 1(2):177-92. PMID: 15046240.
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    25. Hogarth MA, Gertz M, Gorin F. jTerm: an open source terminology server. AMIA Annu Symp Proc. 2003; 861. PMID: 14728366.
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    26. Kaiser A, Nishi K, Gorin FA, Walsh DA, Bradbury EM, Schnier JB. The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase. Arch Biochem Biophys. 2001 Feb 15; 386(2):179-87. PMID: 11368340.
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    27. Gorin F, Hogarth M, Gertz M. The challenges and rewards of integrating diverse neuroscience information. Neuroscientist. 2001 Feb; 7(1):18-27. PMID: 11486341.
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    28. Vali S, Carlsen R, Pessah I, Gorin F. Role of the sarcoplasmic reticulum in regulating the activity-dependent expression of the glycogen phosphorylase gene in contractile skeletal muscle cells. J Cell Physiol. 2000 Nov; 185(2):184-99. PMID: 11025440.
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    29. McLean LA, Roscoe J, Jorgensen NK, Gorin FA, Cala PM. Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes. Am J Physiol Cell Physiol. 2000 Apr; 278(4):C676-88. PMID: 10751317.
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    30. McBride TA, Stockert BW, Gorin FA, Carlsen RC. Stretch-activated ion channels contribute to membrane depolarization after eccentric contractions. J Appl Physiol (1985). 2000 Jan; 88(1):91-101. PMID: 10642367.
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    31. Hogarth MA, Gertz M, Gorin FA. Terminology Query Language: a server interface for concept-oriented terminology systems. Proc AMIA Symp. 2000; 349-53. PMID: 11079903.
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    32. McLean LA, Zia S, Gorin FA, Cala PM. Cloning and expression of the Na+/H+ exchanger from Amphiuma RBCs: resemblance to mammalian NHE1. Am J Physiol. 1999 05; 276(5):C1025-37. PMID: 10329949.
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    33. Gospe SM, El-Schahawi M, Shanske S, Bruno C, DiMauro S, Hoye E, Walsh DA, Gorin FA. Asymptomatic McArdle's disease associated with hyper-creatine kinase-emia and absence of myophosphorylase. Neurology. 1998 Oct; 51(4):1228-9. PMID: 9781574.
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    34. Matthews CC, Carlsen RC, Froman B, Tait R, Gorin F. Nerve-dependent factors regulating transcript levels of glycogen phosphorylase in skeletal muscle. Cell Mol Neurobiol. 1998 Jun; 18(3):319-38. PMID: 9590562.
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    35. Froman BE, Tait RC, Gorin FA. Role of E and CArG boxes in developmental regulation of muscle glycogen phosphorylase promoter during myogenesis. DNA Cell Biol. 1998 Feb; 17(2):105-15. PMID: 9502427.
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    36. Burns MS, Gorin FA, Anderson K, Nihira M. Histochemical demonstration of glycogen in neurons of the cat retina. Invest Ophthalmol Vis Sci. 1996 Sep; 37(10):1937. PMID: 8814132.
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    37. Gorin F, Herrick K, Froman B, Palmer W, Tait R, Carlsen R. Botulinum-induced muscle paralysis alters metabolic gene expression and fatigue recovery. Am J Physiol. 1996 Jan; 270(1 Pt 2):R238-45. PMID: 8769807.
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    38. McBride TA, Gorin FA, Carlsen RC. Prolonged recovery and reduced adaptation in aged rat muscle following eccentric exercise. Mech Ageing Dev. 1995 Sep 15; 83(3):185-200. PMID: 8583836.
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    39. Nihira M, Anderson K, Gorin FA, Burns MS. Primate rod and cone photoreceptors may differ in glucose accessibility. Invest Ophthalmol Vis Sci. 1995 Jun; 36(7):1259-70. PMID: 7775103.
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    40. Wong A, Tait R, Kenny T, Gorin F, Robbins D. A subgroup of human VH3 germline genes that encode a high-avidity synovial rheumatoid factor. Autoimmunity. 1995; 20(3):191-9. PMID: 7578880.
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    41. Froman BE, Herrick KR, Gorin FA. Regulation of the rat muscle glycogen phosphorylase-encoding gene during muscle cell development. Gene. 1994 Nov 18; 149(2):245-52. PMID: 7958997.
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    42. Herrick KR, Gorin FA, Park EA, Tait RC. Characterization of the 5' flanking region of the gene encoding rat liver glycogen phosphorylase. Gene. 1993 Apr 30; 126(2):203-11. PMID: 8482535.
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    43. Davis PA, Leung P, Manns M, Kaplan M, Munoz SJ, Gorin FA, Dickson ER, Krawitt E, Coppel R, Gershwin ME. M4 and M9 antibodies in the overlap syndrome of primary biliary cirrhosis and chronic active hepatitis: epitopes or epiphenomena? Hepatology. 1992 Nov; 16(5):1128-36. PMID: 1330864.
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    44. Cawley KC, Akita CG, Wineinger MA, Carlsen RC, Gorin FA, Walsh DA. Coordinated expression of phosphorylase kinase subunits in regenerating skeletal muscle. J Biol Chem. 1992 Aug 25; 267(24):17287-95. PMID: 1512265.
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    45. Froman BE, Tait RC, Gorin FA, Horwitz BA, Stern JS. The gene encoding rat liver glycogen phosphorylase contains multiple polyadenylation signal sequences. Gene. 1991 Dec 30; 109(2):269-74. PMID: 1765272.
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    46. Wineinger MA, Gorin F, Tait R, Froman B, Carlsen RC. Reduced glycolytic metabolism in regenerated fast-twitch skeletal muscle. Am J Physiol. 1991 Jul; 261(1 Pt 1):C169-76. PMID: 1858853.
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    47. Roscoe JA, Gorin FA, Tait RC. Human astrocytoma U251 RNA and genomic brain glycogen phosphorylase sequences. Brain Res Mol Brain Res. 1991 Jun; 10(3):273-5. PMID: 1715969.
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    48. Gorin F, Baldwin B, Tait R, Pathak R, Seyal M, Mugnaini E. Stiff-man syndrome: a GABAergic autoimmune disorder with autoantigenic heterogeneity. Ann Neurol. 1990 Nov; 28(5):711-4. PMID: 2260859.
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    49. Ignacio PC, Baldwin BA, Vijayan VK, Tait RC, Gorin FA. Brain isozyme of glycogen phosphorylase: immunohistological localization within the central nervous system. Brain Res. 1990 Oct 08; 529(1-2):42-9. PMID: 2282504.
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    50. Gelinas RP, Froman BE, McElroy F, Tait RC, Gorin FA. Human brain glycogen phosphorylase: characterization of fetal cDNA and genomic sequences. Brain Res Mol Brain Res. 1989 Nov; 6(2-3):177-85. PMID: 2615594.
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    51. Gorin F, Ignacio P, Gelinas R, Carlsen R. Abnormal expression of glycogen phosphorylase genes in regenerated muscle. Am J Physiol. 1989 Sep; 257(3 Pt 1):C495-503. PMID: 2528910.
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    52. Gorin F, Kindall D, Seyal M. Dorsal radiculopathy resulting from podophyllin toxicity. Neurology. 1989 Apr; 39(4):607-8. PMID: 2538779.
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    53. Carlson M, Nakamura Y, Gillilan S, O'Connell P, Lebo R, Gorin F, Lathrop GM, Lalouel JM, White R. Isolation and mapping of a polymorphic DNA sequence for human muscle glycogen phosphorylase (pMCMP1) on chromosome II [PYGM]. Nucleic Acids Res. 1988 Nov 11; 16(21):10403. PMID: 2461546.
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    54. Cawley KC, Ramachandran C, Gorin FA, Walsh DA. Nucleotide sequence of cDNA encoding the catalytic subunit of phosphorylase kinase from rat soleus muscle. Nucleic Acids Res. 1988 Mar 25; 16(5):2355-6. PMID: 3357797.
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    55. Gorin FA, Mullinax RL, Ignacio PC, Neve RL, Kurnit DM. McArdle's & Hers' diseases: glycogen phosphorylase transcriptional expression in human tissues. J Neurogenet. 1987 Dec; 4(6):293-308. PMID: 3509980.
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    56. Burke J, Hwang P, Anderson L, Lebo R, Gorin F, Fletterick R. Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase. Proteins. 1987; 2(3):177-87. PMID: 3447177.
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    57. Gorin FA, Bale JF, Halks-Miller M, Schwartz RA. Kaposi's sarcoma metastatic to the CNS. Arch Neurol. 1985 Feb; 42(2):162-5. PMID: 3977646.
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    58. Lebo RV, Gorin F, Fletterick RJ, Kao FT, Cheung MC, Bruce BD, Kan YW. High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11. Science. 1984 Jul 06; 225(4657):57-9. PMID: 6587566.
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    59. Gorin FA, Balasubramanian TM, Cicero TJ, Schwietzer J, Marshall GR. Novel analogues of enkephalin: indentification of functional groups required for biological activity. J Med Chem. 1980 Oct; 23(10):1113-22. PMID: 6252322.
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    60. Gorin FA, Balasubramanian TM, Barry CD, Marshall GR. Elucidation of the receptor-bound conformation of the enkephalins. J Supramol Struct. 1978; 9(1):27-39. PMID: 743340.
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    61. Gorin FA, Marshall GR. Proposal for the biologically active conformation of opiates and enkephalin. Proc Natl Acad Sci U S A. 1977 Nov; 74(11):5179-83. PMID: 270758.
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    62. Gots RE, Gorin FA, Bessman SP. Kinetic enhancement of bound hexokinase activity by mitochondrial respiration. Biochem Biophys Res Commun. 1972 Dec 04; 49(5):1249-55. PMID: 4645545.
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