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Cmpd10357 to treat B-cell acute lymphoblastic leukemia. Exp Hematol. 2023 Mar-Apr; 119-120:8-13.e1.
Lee AQ, Konishi H, Helmke E, Ijiri M, Lerot JMA, Hicks E, Chien JR, Gorin FA, Satake N. PMID: 36621746; PMCID: PMC10033359.
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Translation:
HumansAnimalsCells
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Hippocampal but Not Serum Cytokine Levels Are Altered by Traffic-Related Air Pollution in TgF344-AD and Wildtype Fischer 344 Rats in a Sex- and Age-Dependent Manner. Front Cell Neurosci. 2022; 16:861733.
Patten KT, Valenzuela AE, Wallis C, Harvey DJ, Bein KJ, Wexler AS, Gorin FA, Lein PJ. PMID: 35530180; PMCID: PMC9072828.
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PubMed Mentions:
6
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Review of evidence implicating the plasminogen activator system in blood-brain barrier dysfunction associated with Alzheimer's disease. Ageing Neurodegener Dis. 2022; 2.
Tang MY, Gorin FA, Lein PJ. PMID: 35156107; PMCID: PMC8830591.
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PubMed Mentions:
6
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A clinical decision rule predicting outcomes of emergency department patients with altered mental status. J Am Coll Emerg Physicians Open. 2021 Oct; 2(5):e12522.
Simkins TJ, Bissig D, Moreno G, Kahlon NPK, Gorin F, Duffy A. PMID: 34528023; PMCID: PMC8432088.
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PubMed Mentions:
2
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Label-free fluorescence lifetime spectroscopy detects radiation-induced necrotic changes in live brain in real-time. Biomed Opt Express. 2018 Aug 01; 9(8):3559-3580.
Hartl BA, Ma HSW, Sridharan S, Hansen KS, Kent MS, Gorin F, Fragoso RC, Marcu L. PMID: 30338140; PMCID: PMC6191615.
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PubMed Mentions:
4
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In Vivo MRI of Functionalized Iron Oxide Nanoparticles for Brain Inflammation. Contrast Media Mol Imaging. 2018; 2018:3476476.
Tang T, Valenzuela A, Petit F, Chow S, Leung K, Gorin F, Louie AY, Dhenain M. PMID: 30079001; PMCID: PMC6036843.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Killing Glioma 'Stem-like' Cells via Drug-Induced Relocation of Endosomal Urokinase Proteins. Anticancer Agents Med Chem. 2017; 17(1):40-47.
Gorin FA, Pasupuleti N, Mahajan D, Dugar S. PMID: 27357540.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death. Mol Pharmacol. 2015 Apr; 87(4):683-96.
Pasupuleti N, Grodzki AC, Gorin F. PMID: 25634671; PMCID: PMC4366798.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor α and interleukin-1β expression. J Pharmacol Exp Ther. 2015 Mar; 352(3):438-47.
Grodzki AC, Poola B, Pasupuleti N, Nantz MH, Lein PJ, Gorin F. PMID: 25538105; PMCID: PMC4352593.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Size-stable solid lipid nanoparticles loaded with Gd-DOTA for magnetic resonance imaging. Bioconjug Chem. 2013 Sep 18; 24(9):1455-67.
Andreozzi E, Wang P, Valenzuela A, Tu C, Gorin F, Dhenain M, Louie A. PMID: 24004269.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013; 8(4):e63038.
Leon LJ, Pasupuleti N, Gorin F, Carraway KL. PMID: 23646172; PMCID: PMC3639988.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013 Mar; 344(3):600-15.
Pasupuleti N, Leon L, Carraway KL, Gorin F. PMID: 23241369; PMCID: PMC3583503.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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2-Amidino analogs of glycine-amiloride conjugates: inhibitors of urokinase-type plasminogen activator. Bioorg Med Chem Lett. 2012 Apr 01; 22(7):2635-9.
Massey AP, Harley WR, Pasupuleti N, Gorin FA, Nantz MH. PMID: 22366654; PMCID: PMC3329872.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas. Brain Res. 2010 Dec 02; 1363:159-69.
Harley W, Floyd C, Dunn T, Zhang XD, Chen TY, Hegde M, Palandoken H, Nantz MH, Leon L, Carraway KL, Lyeth B, Gorin FA. PMID: 20869350; PMCID: PMC2996276.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Fluorescence lifetime imaging microscopy for brain tumor image-guided surgery. J Biomed Opt. 2010 Sep-Oct; 15(5):056022.
Sun Y, Hatami N, Yee M, Phipps J, Elson DS, Gorin F, Schrot RJ, Marcu L. PMID: 21054116; PMCID: PMC2966493.
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PubMed Mentions:
62 Fields:
Translation:
Humans
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Differential hippocampal protection when blocking intracellular sodium and calcium entry during traumatic brain injury in rats. J Neurotrauma. 2008 Oct; 25(10):1195-205.
Zhao X, Gorin FA, Berman RF, Lyeth BG. PMID: 18847376; PMCID: PMC2652584.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas. J Neurooncol. 2008 Aug; 89(1):19-26.
Schnier JB, Nishi K, Harley WR, Gorin FA. PMID: 18404250; PMCID: PMC2996278.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson's disease: a dynamic model. Neuroscience. 2007 Nov 23; 149(4):917-30.
Vali S, Mythri RB, Jagatha B, Padiadpu J, Ramanujan KS, Andersen JK, Gorin F, Bharath MM. PMID: 17936517.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis. J Comput Neurosci. 2007 Apr; 22(2):147-60.
Kaushik P, Gorin F, Vali S. PMID: 17053993.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of Parkinson's disease. Neuroscience. 2006 Oct 27; 142(3):859-70.
Raichur A, Vali S, Gorin F. PMID: 16920272.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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Mechanical strain injury increases intracellular sodium and reverses Na+/Ca2+ exchange in cortical astrocytes. Glia. 2005 Jul; 51(1):35-46.
Floyd CL, Gorin FA, Lyeth BG. PMID: 15779085; PMCID: PMC2996279.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Glycogen synthesis correlates with androgen-dependent growth arrest in prostate cancer. BMC Urol. 2005 Mar 24; 5:6.
Schnier JB, Nishi K, Gumerlock PH, Gorin FA, Bradbury EM. PMID: 15790394; PMCID: PMC1079895.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Comparison of vector space model methodologies to reconcile cross-species neuroanatomical concepts. Neuroinformatics. 2005; 3(2):115-31.
Srinivas PR, Wei SH, Cristianini N, Jones EG, Gorin FA. PMID: 15988041.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Amiloride peptide conjugates: prodrugs for sodium-proton exchange inhibition. J Pharmacol Exp Ther. 2005 Mar; 312(3):961-7.
Palandoken H, By K, Hegde M, Harley WR, Gorin FA, Nantz MH. PMID: 15509720.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Amiloride kills malignant glioma cells independent of its inhibition of the sodium-hydrogen exchanger. J Pharmacol Exp Ther. 2004 Jul; 310(1):67-74.
Hegde M, Roscoe J, Cala P, Gorin F. PMID: 15010500.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Perinecrotic glioma proliferation and metabolic profile within an intracerebral tumor xenograft. Acta Neuropathol. 2004 Mar; 107(3):235-44.
Gorin F, Harley W, Schnier J, Lyeth B, Jue T. PMID: 14712400.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression. Biochem Biophys Res Commun. 2003 Sep 12; 309(1):126-34.
Schnier JB, Nishi K, Monks A, Gorin FA, Bradbury EM. PMID: 12943673.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Neuroanatomical term generation and comparison between two terminologies. Neuroinformatics. 2003; 1(2):177-92.
Srinivas PR, Gusfield D, Mason O, Gertz M, Hogarth M, Stone J, Jones EG, Gorin FA. PMID: 15046240.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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jTerm: an open source terminology server. AMIA Annu Symp Proc. 2003; 861.
Hogarth MA, Gertz M, Gorin F. PMID: 14728366; PMCID: PMC1480285.
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Humans
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The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase. Arch Biochem Biophys. 2001 Feb 15; 386(2):179-87.
Kaiser A, Nishi K, Gorin FA, Walsh DA, Bradbury EM, Schnier JB. PMID: 11368340.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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The challenges and rewards of integrating diverse neuroscience information. Neuroscientist. 2001 Feb; 7(1):18-27.
Gorin F, Hogarth M, Gertz M. PMID: 11486341.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Role of the sarcoplasmic reticulum in regulating the activity-dependent expression of the glycogen phosphorylase gene in contractile skeletal muscle cells. J Cell Physiol. 2000 Nov; 185(2):184-99.
Vali S, Carlsen R, Pessah I, Gorin F. PMID: 11025440.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes. Am J Physiol Cell Physiol. 2000 Apr; 278(4):C676-88.
McLean LA, Roscoe J, Jorgensen NK, Gorin FA, Cala PM. PMID: 10751317.
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PubMed Mentions:
59 Fields:
Translation:
HumansCells
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Stretch-activated ion channels contribute to membrane depolarization after eccentric contractions. J Appl Physiol (1985). 2000 Jan; 88(1):91-101.
McBride TA, Stockert BW, Gorin FA, Carlsen RC. PMID: 10642367.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Terminology Query Language: a server interface for concept-oriented terminology systems. Proc AMIA Symp. 2000; 349-53.
Hogarth MA, Gertz M, Gorin FA. PMID: 11079903; PMCID: PMC2244076.
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PubMed Mentions:
4 Fields:
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Cloning and expression of the Na+/H+ exchanger from Amphiuma RBCs: resemblance to mammalian NHE1. Am J Physiol. 1999 05; 276(5):C1025-37.
McLean LA, Zia S, Gorin FA, Cala PM. PMID: 10329949.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Asymptomatic McArdle's disease associated with hyper-creatine kinase-emia and absence of myophosphorylase. Neurology. 1998 Oct; 51(4):1228-9.
Gospe SM, El-Schahawi M, Shanske S, Bruno C, DiMauro S, Hoye E, Walsh DA, Gorin FA. PMID: 9781574.
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Humans
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Nerve-dependent factors regulating transcript levels of glycogen phosphorylase in skeletal muscle. Cell Mol Neurobiol. 1998 Jun; 18(3):319-38.
Matthews CC, Carlsen RC, Froman B, Tait R, Gorin F. PMID: 9590562.
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AnimalsCells
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Role of E and CArG boxes in developmental regulation of muscle glycogen phosphorylase promoter during myogenesis. DNA Cell Biol. 1998 Feb; 17(2):105-15.
Froman BE, Tait RC, Gorin FA. PMID: 9502427.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Histochemical demonstration of glycogen in neurons of the cat retina. Invest Ophthalmol Vis Sci. 1996 Sep; 37(10):1937.
Burns MS, Gorin FA, Anderson K, Nihira M. PMID: 8814132.
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AnimalsCells
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Botulinum-induced muscle paralysis alters metabolic gene expression and fatigue recovery. Am J Physiol. 1996 Jan; 270(1 Pt 2):R238-45.
Gorin F, Herrick K, Froman B, Palmer W, Tait R, Carlsen R. PMID: 8769807.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Prolonged recovery and reduced adaptation in aged rat muscle following eccentric exercise. Mech Ageing Dev. 1995 Sep 15; 83(3):185-200.
McBride TA, Gorin FA, Carlsen RC. PMID: 8583836.
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PubMed Mentions:
29 Fields:
Translation:
Animals
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Primate rod and cone photoreceptors may differ in glucose accessibility. Invest Ophthalmol Vis Sci. 1995 Jun; 36(7):1259-70.
Nihira M, Anderson K, Gorin FA, Burns MS. PMID: 7775103.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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A subgroup of human VH3 germline genes that encode a high-avidity synovial rheumatoid factor. Autoimmunity. 1995; 20(3):191-9.
Wong A, Tait R, Kenny T, Gorin F, Robbins D. PMID: 7578880.
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HumansCells
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Regulation of the rat muscle glycogen phosphorylase-encoding gene during muscle cell development. Gene. 1994 Nov 18; 149(2):245-52.
Froman BE, Herrick KR, Gorin FA. PMID: 7958997.
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HumansAnimalsCells
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Characterization of the 5' flanking region of the gene encoding rat liver glycogen phosphorylase. Gene. 1993 Apr 30; 126(2):203-11.
Herrick KR, Gorin FA, Park EA, Tait RC. PMID: 8482535.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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M4 and M9 antibodies in the overlap syndrome of primary biliary cirrhosis and chronic active hepatitis: epitopes or epiphenomena? Hepatology. 1992 Nov; 16(5):1128-36.
Davis PA, Leung P, Manns M, Kaplan M, Munoz SJ, Gorin FA, Dickson ER, Krawitt E, Coppel R, Gershwin ME. PMID: 1330864.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Coordinated expression of phosphorylase kinase subunits in regenerating skeletal muscle. J Biol Chem. 1992 Aug 25; 267(24):17287-95.
Cawley KC, Akita CG, Wineinger MA, Carlsen RC, Gorin FA, Walsh DA. PMID: 1512265.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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The gene encoding rat liver glycogen phosphorylase contains multiple polyadenylation signal sequences. Gene. 1991 Dec 30; 109(2):269-74.
Froman BE, Tait RC, Gorin FA, Horwitz BA, Stern JS. PMID: 1765272.
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AnimalsCells
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Reduced glycolytic metabolism in regenerated fast-twitch skeletal muscle. Am J Physiol. 1991 Jul; 261(1 Pt 1):C169-76.
Wineinger MA, Gorin F, Tait R, Froman B, Carlsen RC. PMID: 1858853.
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AnimalsCells
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Human astrocytoma U251 RNA and genomic brain glycogen phosphorylase sequences. Brain Res Mol Brain Res. 1991 Jun; 10(3):273-5.
Roscoe JA, Gorin FA, Tait RC. PMID: 1715969.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Stiff-man syndrome: a GABAergic autoimmune disorder with autoantigenic heterogeneity. Ann Neurol. 1990 Nov; 28(5):711-4.
Gorin F, Baldwin B, Tait R, Pathak R, Seyal M, Mugnaini E. PMID: 2260859.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Brain isozyme of glycogen phosphorylase: immunohistological localization within the central nervous system. Brain Res. 1990 Oct 08; 529(1-2):42-9.
Ignacio PC, Baldwin BA, Vijayan VK, Tait RC, Gorin FA. PMID: 2282504.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Human brain glycogen phosphorylase: characterization of fetal cDNA and genomic sequences. Brain Res Mol Brain Res. 1989 Nov; 6(2-3):177-85.
Gelinas RP, Froman BE, McElroy F, Tait RC, Gorin FA. PMID: 2615594.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Abnormal expression of glycogen phosphorylase genes in regenerated muscle. Am J Physiol. 1989 Sep; 257(3 Pt 1):C495-503.
Gorin F, Ignacio P, Gelinas R, Carlsen R. PMID: 2528910.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Dorsal radiculopathy resulting from podophyllin toxicity. Neurology. 1989 Apr; 39(4):607-8.
Gorin F, Kindall D, Seyal M. PMID: 2538779.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Isolation and mapping of a polymorphic DNA sequence for human muscle glycogen phosphorylase (pMCMP1) on chromosome II [PYGM]. Nucleic Acids Res. 1988 Nov 11; 16(21):10403.
Carlson M, Nakamura Y, Gillilan S, O'Connell P, Lebo R, Gorin F, Lathrop GM, Lalouel JM, White R. PMID: 2461546; PMCID: PMC338902.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Nucleotide sequence of cDNA encoding the catalytic subunit of phosphorylase kinase from rat soleus muscle. Nucleic Acids Res. 1988 Mar 25; 16(5):2355-6.
Cawley KC, Ramachandran C, Gorin FA, Walsh DA. PMID: 3357797; PMCID: PMC338242.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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McArdle's & Hers' diseases: glycogen phosphorylase transcriptional expression in human tissues. J Neurogenet. 1987 Dec; 4(6):293-308.
Gorin FA, Mullinax RL, Ignacio PC, Neve RL, Kurnit DM. PMID: 3509980.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase. Proteins. 1987; 2(3):177-87.
Burke J, Hwang P, Anderson L, Lebo R, Gorin F, Fletterick R. PMID: 3447177.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Kaposi's sarcoma metastatic to the CNS. Arch Neurol. 1985 Feb; 42(2):162-5.
Gorin FA, Bale JF, Halks-Miller M, Schwartz RA. PMID: 3977646.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11. Science. 1984 Jul 06; 225(4657):57-9.
Lebo RV, Gorin F, Fletterick RJ, Kao FT, Cheung MC, Bruce BD, Kan YW. PMID: 6587566.
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PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
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Novel analogues of enkephalin: indentification of functional groups required for biological activity. J Med Chem. 1980 Oct; 23(10):1113-22.
Gorin FA, Balasubramanian TM, Cicero TJ, Schwietzer J, Marshall GR. PMID: 6252322.
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AnimalsCells
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Elucidation of the receptor-bound conformation of the enkephalins. J Supramol Struct. 1978; 9(1):27-39.
Gorin FA, Balasubramanian TM, Barry CD, Marshall GR. PMID: 743340.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Chapter 24. Peptide Conformation and Biological Activity. . 1978 Jan 1; 13:227-238.
Marshall MG, Gorin GF, Moore MM. .
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Proposal for the biologically active conformation of opiates and enkephalin. Proc Natl Acad Sci U S A. 1977 Nov; 74(11):5179-83.
Gorin FA, Marshall GR. PMID: 270758; PMCID: PMC432125.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Kinetic enhancement of bound hexokinase activity by mitochondrial respiration. Biochem Biophys Res Commun. 1972 Dec 04; 49(5):1249-55.
Gots RE, Gorin FA, Bessman SP. PMID: 4645545.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells