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Fredric A Gorin, MD; PhD

Title(s)Professor, Neurology
SchoolUniversity of California, Davis
Address4860 Y St. Suite 3700
CA 95817
Phone916-734-6284
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    Collapse Research 
    Collapse Research Activities and Funding
    Novel Glioma uPA Inhibitor Design Guided by Intracellular signaling Pathways
    NIH/NINDS R01NS060880Sep 1, 2009 - Jan 31, 2012
    Role: Principal Investigator
    Novel Amiloride Conjugates Selectively Kill Gliomas
    NIH/NINDS R01NS040489Jun 1, 2001 - Mar 31, 2010
    Role: Principal Investigator
    BRAIN GLYCOGEN PHOSPHORYLASE IN HYPOXIC-ISCHEMIC EVENTS
    NIH/NINDS R01NS023644Sep 1, 1985 - Aug 31, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Label-free fluorescence lifetime spectroscopy detects radiation-induced necrotic changes in live brain in real-time. Biomed Opt Express. 2018 Aug 01; 9(8):3559-3580. Hartl BA, Ma HSW, Sridharan S, Hansen KS, Kent MS, Gorin F, Fragoso RC, Marcu L. PMID: 30338140.
      View in: PubMed   Mentions:
    2. In Vivo MRI of Functionalized Iron Oxide Nanoparticles for Brain Inflammation. Contrast Media Mol Imaging. 2018; 2018:3476476. Tang T, Valenzuela A, Petit F, Chow S, Leung K, Gorin F, Louie AY, Dhenain M. PMID: 30079001.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. Killing Glioma 'Stem-like' Cells via Drug-Induced Relocation of Endosomal Urokinase Proteins. Anticancer Agents Med Chem. 2017; 17(1):40-47. Gorin FA, Pasupuleti N, Mahajan D, Dugar S. PMID: 27357540.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death. Mol Pharmacol. 2015 Apr; 87(4):683-96. Pasupuleti N, Grodzki AC, Gorin F. PMID: 25634671.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    5. A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor a and interleukin-1ß expression. J Pharmacol Exp Ther. 2015 Mar; 352(3):438-47. Grodzki AC, Poola B, Pasupuleti N, Nantz MH, Lein PJ, Gorin F. PMID: 25538105.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Size-stable solid lipid nanoparticles loaded with Gd-DOTA for magnetic resonance imaging. Bioconjug Chem. 2013 Sep 18; 24(9):1455-67. Andreozzi E, Wang P, Valenzuela A, Tu C, Gorin F, Dhenain M, Louie A. PMID: 24004269.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013; 8(4):e63038. Leon LJ, Pasupuleti N, Gorin F, Carraway KL. PMID: 23646172.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    8. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013 Mar; 344(3):600-15. Pasupuleti N, Leon L, Carraway KL, Gorin F. PMID: 23241369.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    9. 2-Amidino analogs of glycine-amiloride conjugates: inhibitors of urokinase-type plasminogen activator. Bioorg Med Chem Lett. 2012 Apr 01; 22(7):2635-9. Massey AP, Harley WR, Pasupuleti N, Gorin FA, Nantz MH. PMID: 22366654.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas. Brain Res. 2010 Dec 02; 1363:159-69. Harley W, Floyd C, Dunn T, Zhang XD, Chen TY, Hegde M, Palandoken H, Nantz MH, Leon L, Carraway KL, Lyeth B, Gorin FA. PMID: 20869350.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    11. Fluorescence lifetime imaging microscopy for brain tumor image-guided surgery. J Biomed Opt. 2010 Sep-Oct; 15(5):056022. Sun Y, Hatami N, Yee M, Phipps J, Elson DS, Gorin F, Schrot RJ, Marcu L. PMID: 21054116.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    12. Differential hippocampal protection when blocking intracellular sodium and calcium entry during traumatic brain injury in rats. J Neurotrauma. 2008 Oct; 25(10):1195-205. Zhao X, Gorin FA, Berman RF, Lyeth BG. PMID: 18847376.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    13. An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas. J Neurooncol. 2008 Aug; 89(1):19-26. Schnier JB, Nishi K, Harley WR, Gorin FA. PMID: 18404250.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    14. Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson's disease: a dynamic model. Neuroscience. 2007 Nov 23; 149(4):917-30. Vali S, Mythri RB, Jagatha B, Padiadpu J, Ramanujan KS, Andersen JK, Gorin F, Bharath MM. PMID: 17936517.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    15. Dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis. J Comput Neurosci. 2007 Apr; 22(2):147-60. Kaushik P, Gorin F, Vali S. PMID: 17053993.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    16. Dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of Parkinson's disease. Neuroscience. 2006 Oct 27; 142(3):859-70. Raichur A, Vali S, Gorin F. PMID: 16920272.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    17. Mechanical strain injury increases intracellular sodium and reverses Na+/Ca2+ exchange in cortical astrocytes. Glia. 2005 Jul; 51(1):35-46. Floyd CL, Gorin FA, Lyeth BG. PMID: 15779085.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    18. Glycogen synthesis correlates with androgen-dependent growth arrest in prostate cancer. BMC Urol. 2005 Mar 24; 5:6. Schnier JB, Nishi K, Gumerlock PH, Gorin FA, Bradbury EM. PMID: 15790394.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    19. Comparison of vector space model methodologies to reconcile cross-species neuroanatomical concepts. Neuroinformatics. 2005; 3(2):115-31. Srinivas PR, Wei SH, Cristianini N, Jones EG, Gorin FA. PMID: 15988041.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    20. Amiloride peptide conjugates: prodrugs for sodium-proton exchange inhibition. J Pharmacol Exp Ther. 2005 Mar; 312(3):961-7. Palandoken H, By K, Hegde M, Harley WR, Gorin FA, Nantz MH. PMID: 15509720.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    21. Amiloride kills malignant glioma cells independent of its inhibition of the sodium-hydrogen exchanger. J Pharmacol Exp Ther. 2004 Jul; 310(1):67-74. Hegde M, Roscoe J, Cala P, Gorin F. PMID: 15010500.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    22. Perinecrotic glioma proliferation and metabolic profile within an intracerebral tumor xenograft. Acta Neuropathol. 2004 Mar; 107(3):235-44. Gorin F, Harley W, Schnier J, Lyeth B, Jue T. PMID: 14712400.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    23. Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression. Biochem Biophys Res Commun. 2003 Sep 12; 309(1):126-34. Schnier JB, Nishi K, Monks A, Gorin FA, Bradbury EM. PMID: 12943673.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    24. Neuroanatomical term generation and comparison between two terminologies. Neuroinformatics. 2003; 1(2):177-92. Srinivas PR, Gusfield D, Mason O, Gertz M, Hogarth M, Stone J, Jones EG, Gorin FA. PMID: 15046240.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    25. jTerm: an open source terminology server. AMIA Annu Symp Proc. 2003; 861. Hogarth MA, Gertz M, Gorin F. PMID: 14728366.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase. Arch Biochem Biophys. 2001 Feb 15; 386(2):179-87. Kaiser A, Nishi K, Gorin FA, Walsh DA, Bradbury EM, Schnier JB. PMID: 11368340.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    27. The challenges and rewards of integrating diverse neuroscience information. Neuroscientist. 2001 Feb; 7(1):18-27. Gorin F, Hogarth M, Gertz M. PMID: 11486341.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    28. Role of the sarcoplasmic reticulum in regulating the activity-dependent expression of the glycogen phosphorylase gene in contractile skeletal muscle cells. J Cell Physiol. 2000 Nov; 185(2):184-99. Vali S, Carlsen R, Pessah I, Gorin F. PMID: 11025440.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    29. Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes. Am J Physiol Cell Physiol. 2000 Apr; 278(4):C676-88. McLean LA, Roscoe J, Jorgensen NK, Gorin FA, Cala PM. PMID: 10751317.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    30. Stretch-activated ion channels contribute to membrane depolarization after eccentric contractions. J Appl Physiol (1985). 2000 Jan; 88(1):91-101. McBride TA, Stockert BW, Gorin FA, Carlsen RC. PMID: 10642367.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    31. Terminology Query Language: a server interface for concept-oriented terminology systems. Proc AMIA Symp. 2000; 349-53. Hogarth MA, Gertz M, Gorin FA. PMID: 11079903.
      View in: PubMed   Mentions: 3     Fields:    
    32. Cloning and expression of the Na+/H+ exchanger from Amphiuma RBCs: resemblance to mammalian NHE1. Am J Physiol. 1999 05; 276(5):C1025-37. McLean LA, Zia S, Gorin FA, Cala PM. PMID: 10329949.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    33. Asymptomatic McArdle's disease associated with hyper-creatine kinase-emia and absence of myophosphorylase. Neurology. 1998 Oct; 51(4):1228-9. Gospe SM, El-Schahawi M, Shanske S, Bruno C, DiMauro S, Hoye E, Walsh DA, Gorin FA. PMID: 9781574.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Nerve-dependent factors regulating transcript levels of glycogen phosphorylase in skeletal muscle. Cell Mol Neurobiol. 1998 Jun; 18(3):319-38. Matthews CC, Carlsen RC, Froman B, Tait R, Gorin F. PMID: 9590562.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    35. Role of E and CArG boxes in developmental regulation of muscle glycogen phosphorylase promoter during myogenesis. DNA Cell Biol. 1998 Feb; 17(2):105-15. Froman BE, Tait RC, Gorin FA. PMID: 9502427.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    36. Histochemical demonstration of glycogen in neurons of the cat retina. Invest Ophthalmol Vis Sci. 1996 Sep; 37(10):1937. Burns MS, Gorin FA, Anderson K, Nihira M. PMID: 8814132.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    37. Botulinum-induced muscle paralysis alters metabolic gene expression and fatigue recovery. Am J Physiol. 1996 Jan; 270(1 Pt 2):R238-45. Gorin F, Herrick K, Froman B, Palmer W, Tait R, Carlsen R. PMID: 8769807.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    38. Prolonged recovery and reduced adaptation in aged rat muscle following eccentric exercise. Mech Ageing Dev. 1995 Sep 15; 83(3):185-200. McBride TA, Gorin FA, Carlsen RC. PMID: 8583836.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    39. Primate rod and cone photoreceptors may differ in glucose accessibility. Invest Ophthalmol Vis Sci. 1995 Jun; 36(7):1259-70. Nihira M, Anderson K, Gorin FA, Burns MS. PMID: 7775103.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    40. A subgroup of human VH3 germline genes that encode a high-avidity synovial rheumatoid factor. Autoimmunity. 1995; 20(3):191-9. Wong A, Tait R, Kenny T, Gorin F, Robbins D. PMID: 7578880.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    41. Regulation of the rat muscle glycogen phosphorylase-encoding gene during muscle cell development. Gene. 1994 Nov 18; 149(2):245-52. Froman BE, Herrick KR, Gorin FA. PMID: 7958997.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    42. Characterization of the 5' flanking region of the gene encoding rat liver glycogen phosphorylase. Gene. 1993 Apr 30; 126(2):203-11. Herrick KR, Gorin FA, Park EA, Tait RC. PMID: 8482535.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    43. M4 and M9 antibodies in the overlap syndrome of primary biliary cirrhosis and chronic active hepatitis: epitopes or epiphenomena? Hepatology. 1992 Nov; 16(5):1128-36. Davis PA, Leung P, Manns M, Kaplan M, Munoz SJ, Gorin FA, Dickson ER, Krawitt E, Coppel R, Gershwin ME. PMID: 1330864.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    44. Coordinated expression of phosphorylase kinase subunits in regenerating skeletal muscle. J Biol Chem. 1992 Aug 25; 267(24):17287-95. Cawley KC, Akita CG, Wineinger MA, Carlsen RC, Gorin FA, Walsh DA. PMID: 1512265.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    45. The gene encoding rat liver glycogen phosphorylase contains multiple polyadenylation signal sequences. Gene. 1991 Dec 30; 109(2):269-74. Froman BE, Tait RC, Gorin FA, Horwitz BA, Stern JS. PMID: 1765272.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    46. Reduced glycolytic metabolism in regenerated fast-twitch skeletal muscle. Am J Physiol. 1991 Jul; 261(1 Pt 1):C169-76. Wineinger MA, Gorin F, Tait R, Froman B, Carlsen RC. PMID: 1858853.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    47. Human astrocytoma U251 RNA and genomic brain glycogen phosphorylase sequences. Brain Res Mol Brain Res. 1991 Jun; 10(3):273-5. Roscoe JA, Gorin FA, Tait RC. PMID: 1715969.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    48. Stiff-man syndrome: a GABAergic autoimmune disorder with autoantigenic heterogeneity. Ann Neurol. 1990 Nov; 28(5):711-4. Gorin F, Baldwin B, Tait R, Pathak R, Seyal M, Mugnaini E. PMID: 2260859.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    49. Brain isozyme of glycogen phosphorylase: immunohistological localization within the central nervous system. Brain Res. 1990 Oct 08; 529(1-2):42-9. Ignacio PC, Baldwin BA, Vijayan VK, Tait RC, Gorin FA. PMID: 2282504.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    50. Human brain glycogen phosphorylase: characterization of fetal cDNA and genomic sequences. Brain Res Mol Brain Res. 1989 Nov; 6(2-3):177-85. Gelinas RP, Froman BE, McElroy F, Tait RC, Gorin FA. PMID: 2615594.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    51. Abnormal expression of glycogen phosphorylase genes in regenerated muscle. Am J Physiol. 1989 Sep; 257(3 Pt 1):C495-503. Gorin F, Ignacio P, Gelinas R, Carlsen R. PMID: 2528910.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    52. Dorsal radiculopathy resulting from podophyllin toxicity. Neurology. 1989 Apr; 39(4):607-8. Gorin F, Kindall D, Seyal M. PMID: 2538779.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    53. Isolation and mapping of a polymorphic DNA sequence for human muscle glycogen phosphorylase (pMCMP1) on chromosome II [PYGM]. Nucleic Acids Res. 1988 Nov 11; 16(21):10403. Carlson M, Nakamura Y, Gillilan S, O'Connell P, Lebo R, Gorin F, Lathrop GM, Lalouel JM, White R. PMID: 2461546.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    54. Nucleotide sequence of cDNA encoding the catalytic subunit of phosphorylase kinase from rat soleus muscle. Nucleic Acids Res. 1988 Mar 25; 16(5):2355-6. Cawley KC, Ramachandran C, Gorin FA, Walsh DA. PMID: 3357797.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    55. McArdle's & Hers' diseases: glycogen phosphorylase transcriptional expression in human tissues. J Neurogenet. 1987 Dec; 4(6):293-308. Gorin FA, Mullinax RL, Ignacio PC, Neve RL, Kurnit DM. PMID: 3509980.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    56. Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase. Proteins. 1987; 2(3):177-87. Burke J, Hwang P, Anderson L, Lebo R, Gorin F, Fletterick R. PMID: 3447177.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    57. Kaposi's sarcoma metastatic to the CNS. Arch Neurol. 1985 Feb; 42(2):162-5. Gorin FA, Bale JF, Halks-Miller M, Schwartz RA. PMID: 3977646.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    58. High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11. Science. 1984 Jul 06; 225(4657):57-9. Lebo RV, Gorin F, Fletterick RJ, Kao FT, Cheung MC, Bruce BD, Kan YW. PMID: 6587566.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    59. Novel analogues of enkephalin: indentification of functional groups required for biological activity. J Med Chem. 1980 Oct; 23(10):1113-22. Gorin FA, Balasubramanian TM, Cicero TJ, Schwietzer J, Marshall GR. PMID: 6252322.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    60. Elucidation of the receptor-bound conformation of the enkephalins. J Supramol Struct. 1978; 9(1):27-39. Gorin FA, Balasubramanian TM, Barry CD, Marshall GR. PMID: 743340.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    61. Chapter 24. Peptide Conformation and Biological Activity. . 1978 Jan 1; 13:227-238. Garland R. Marshall, Fredric A. Gorin, Michael L. Moore. .
      View in: Publisher Site   Mentions:
    62. Proposal for the biologically active conformation of opiates and enkephalin. Proc Natl Acad Sci U S A. 1977 Nov; 74(11):5179-83. Gorin FA, Marshall GR. PMID: 270758.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    63. Kinetic enhancement of bound hexokinase activity by mitochondrial respiration. Biochem Biophys Res Commun. 1972 Dec 04; 49(5):1249-55. Gots RE, Gorin FA, Bessman SP. PMID: 4645545.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
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