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Pamela J Lein

Title(s)Professor, SCHOOL OF VETERINARY MEDICINE
SchoolUniversity of California, Davis
Phone530-752-1970
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    Collapse Research 
    Collapse Research Activities and Funding
    PCB Epigenomic Brain & Behavior Lasting Effects Study (PEBBLES)
    NIH/NIEHS R01ES029213Jun 1, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Vascular Inflammation and Exosomes as Mediators in Aging and Dementia
    NIH/NIA R01AG056710Mar 15, 2018 - Feb 28, 2023
    Role: Co-Principal Investigator
    Does air pollution increase risk of AD in a genetically susceptible animal model?
    NIH/NIEHS R21ES026515Jun 1, 2016 - May 31, 2018
    Role: Principal Investigator
    Novel Anticonvulsant and Neuroprotective Therapies for TETS and OP Intoxication
    NIH/NINDS U54NS079202Sep 1, 2012 - May 31, 2022
    Role: Principal Investigator
    Identification of novel therapeutic approaches for TETS and OP intoxication
    NIH/NINDS R21NS072094Sep 30, 2010 - Aug 31, 2013
    Role: Principal Investigator
    Role of macrophages in organophosphorus pesticide-induced airway hyperreactivity
    NIH/NIEHS R01ES017592Jul 7, 2010 - Apr 30, 2015
    Role: Principal Investigator
    Enantioselective Metabolism Influences PCB Developmental Neurotoxicity
    NIH/NIEHS R01ES017425Jan 26, 2010 - Dec 31, 2015
    Role: Co-Principal Investigator
    Biomarkers of Organophosphorus Pesticide-Induced Neurotoxicity
    NIH/NIEHS R01ES016308Jun 1, 2008 - Apr 30, 2013
    Role: Co-Principal Investigator
    Molecular and Cellular Basis of PCB Developmental Neurotoxicity
    NIH/NIEHS R56ES014901Aug 1, 2007 - Jul 31, 2008
    Role: Principal Investigator
    Molecular and Cellular Basis of PCB Developmental Neurotoxicity
    NIH/NIEHS R01ES014901Jul 1, 2006 - Nov 30, 2019
    Role: Principal Investigator
    Molecular Regulation of Primary Dendritogenesis
    NIH/NINDS R21NS045037Jan 15, 2004 - Dec 31, 2006
    Role: Principal Investigator
    Retrograde Dystrophic Influence of IFN-gamma on Neurons
    NIH/NINDS R01NS046649Jul 16, 2003 - Apr 30, 2009
    Role: Principal Investigator
    Mechanism of organophosphate development neurotoxicity
    NIH/NIEHS R21ES011771Mar 15, 2002 - Jul 31, 2005
    Role: Principal Investigator
    Do PCBs alter developing brain structure and cognition?
    NIH/NICHD R03HD040936Mar 15, 2002 - Aug 31, 2004
    Role: Principal Investigator
    REGULATION OF DENDRITIC GROWTH BY OSTEOGENIC PROTEIN-1
    NIH/NINDS R15NS036401May 15, 1997 - Apr 30, 2000
    Role: Principal Investigator
    CELL BIOLOGY OF HUMAN TILS ENGRAFTED INTO SCID MICE
    NIH/NCI F32CA009177Feb 19, 1992
    Role: Principal Investigator
    Advanced Training in Environmental Health Sciences
    NIH/NIEHS T32ES007059Jul 1, 1978 - Jun 30, 2023
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Klocke C, Sethi S, Lein PJ. The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences. Environ Sci Pollut Res Int. 2019 Nov 12. PMID: 31713823.
      View in: PubMed
    2. Bruce M, Streifel KM, Boosalis CA, Heuer L, González EA, Li S, Harvey DJ, Lein PJ, Van de Water J. Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain. J Neuroinflammation. 2019 Oct 31; 16(1):200. PMID: 31672161.
      View in: PubMed
    3. Walter KM, Dach K, Hayakawa K, Giersiefer S, Heuer H, Lein PJ, Fritsche E. Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. PLoS One. 2019; 14(9):e0221230. PMID: 31513589.
      View in: PubMed
    4. Yang J, Bruun DA, Wang C, Wan D, Reynolds CB, Phu K, Inceoglu B, Lein PJ, Hammock BD. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicol Appl Pharmacol. 2019 Sep 12; 114749. PMID: 31521729.
      View in: PubMed
    5. Hobson BA, Rowland DJ, Sisó S, Guignet MA, Harmany ZT, Bandara SB, Saito N, Harvey DJ, Bruun DA, Garbow JR, Chaudhari AJ, Lein PJ. TSPO PET Using [18F]PBR111 Reveals Persistent Neuroinflammation Following Acute Diisopropylfluorophosphate Intoxication in the Rat. Toxicol Sci. 2019 Aug 01; 170(2):330-344. PMID: 31087103.
      View in: PubMed
    6. Rude KM, Pusceddu MM, Keogh CE, Sladek JA, Rabasa G, Miller EN, Sethi S, Keil KP, Pessah IN, Lein PJ, Gareau MG. Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice. Environ Pollut. 2019 Oct; 253:708-721. PMID: 31336350.
      View in: PubMed
    7. Hennebelle M, Morgan RK, Sethi S, Zhang Z, Chen H, Grodzki AC, Lein PJ, Taha AY. Linoleic acid-derived metabolites constitute the majority of oxylipins in the rat pup brain and stimulate axonal growth in primary rat cortical neuron-glia co-cultures in a sex-dependent manner. J Neurochem. 2019 Jul 08. PMID: 31283837.
      View in: PubMed
    8. Karey E, Pan S, Morris AN, Bruun DA, Lein PJ, Chen CY. The Use of Percent Change in RR Interval for Data Exclusion in Analyzing 24-h Time Domain Heart Rate Variability in Rodents. Front Physiol. 2019; 10:693. PMID: 31244671.
      View in: PubMed
    9. Walter KM, Miller GW, Chen X, Harvey DJ, Puschner B, Lein PJ. Changes in thyroid hormone activity disrupt photomotor behavior of larval zebrafish. Neurotoxicology. 2019 Sep; 74:47-57. PMID: 31121238.
      View in: PubMed
    10. Pravoverov K, Whiting K, Thapa S, Bushong T, Trang K, Lein PJ, Chandrasekaran V. MicroRNAs are Necessary for BMP-7-induced Dendritic Growth in Cultured Rat Sympathetic Neurons. Cell Mol Neurobiol. 2019 Oct; 39(7):917-934. PMID: 31104181.
      View in: PubMed
    11. Proskocil BJ, Grodzki ACG, Jacoby DB, Lein PJ, Fryer AD. Organophosphorus Pesticides Induce Cytokine Release from Differentiated Human THP1 Cells. Am J Respir Cell Mol Biol. 2019 Apr 12. PMID: 30978295.
      View in: PubMed
    12. Pessah IN, Lein PJ, Seegal RF, Sagiv SK. Neurotoxicity of polychlorinated biphenyls and related organohalogens. Acta Neuropathol. 2019 Sep; 138(3):363-387. PMID: 30976975.
      View in: PubMed
    13. Guignet M, Dhakal K, Flannery BM, Hobson BA, Zolkowska D, Dhir A, Bruun DA, Li S, Wahab A, Harvey DJ, Silverman JL, Rogawski MA, Lein PJ. Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication. Neurobiol Dis. 2019 Mar 21; 104431. PMID: 30905768.
      View in: PubMed
    14. Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler HJ, Pessah IN, Lein PJ. Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor. Environ Sci Technol. 2019 04 02; 53(7):3948-3958. PMID: 30821444.
      View in: PubMed
    15. Bruun DA, Guignet M, Harvey DJ, Lein PJ. Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication. Neurotoxicology. 2019 Jul; 73:81-84. PMID: 30853371.
      View in: PubMed
    16. Keil KP, Sethi S, Lein PJ. Sex-Dependent Effects of 2,2',3,5',6-Pentachlorobiphenyl on Dendritic Arborization of Primary Mouse Neurons. Toxicol Sci. 2019 03 01; 168(1):95-109. PMID: 30395321.
      View in: PubMed
    17. Stamou M, Lein PJ. Commentary: Fc Gamma Receptors are Expressed in the Developing Rat Brain and Activate Downstream Signaling Molecules upon Cross-Linking with Immune Complex. J Neurol Neuromedicine. 2019; 4(1):26-29. PMID: 31131371.
      View in: PubMed
    18. Dach K, Yaghoobi B, Schmuck MR, Carty DR, Morales KM, Lein PJ. Teratological and Behavioral Screening of the National Toxicology Program 91-Compound Library in Zebrafish (Danio rerio). Toxicol Sci. 2019 01 01; 167(1):77-91. PMID: 30364989.
      View in: PubMed
    19. Walter KM, Miller GW, Chen X, Yaghoobi B, Puschner B, Lein PJ. Effects of thyroid hormone disruption on the ontogenetic expression of thyroid hormone signaling genes in developing zebrafish (Danio rerio). Gen Comp Endocrinol. 2019 02 01; 272:20-32. PMID: 30448381.
      View in: PubMed
    20. González EA, Carty DR, Tran FD, Cole AM, Lein PJ. Developmental exposure to silver nanoparticles at environmentally relevant concentrations alters swimming behavior in zebrafish (Danio rerio). Environ Toxicol Chem. 2018 12; 37(12):3018-3024. PMID: 30242895.
      View in: PubMed
    21. Keil KP, Sethi S, Wilson MD, Silverman JL, Pessah IN, Lein PJ. Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice. Genes Brain Behav. 2019 01; 18(1):e12526. PMID: 30311737.
      View in: PubMed
    22. Saldarriaga W, Salcedo-Arellano MJ, Rodriguez-Guerrero T, Ríos M, Fandiño-Losada A, Ramirez-Cheyne J, Lein PJ, Tassone F, Hagerman RJ. Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia. Int J Dev Neurosci. 2019 Feb; 72:1-5. PMID: 30385191.
      View in: PubMed
    23. Frank DF, Brander SM, Hasenbein S, Harvey DJ, Lein PJ, Geist J, Connon RE. Developmental exposure to environmentally relevant concentrations of bifenthrin alters transcription of mTOR and ryanodine receptor-dependent signaling molecules and impairs predator avoidance behavior across early life stages in inland silversides (Menidia beryllina). Aquat Toxicol. 2019 Jan; 206:1-13. PMID: 30414561.
      View in: PubMed
    24. Sethi S, Keil KP, Lein PJ. 3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. Arch Toxicol. 2018 11; 92(11):3337-3345. PMID: 30225637.
      View in: PubMed
    25. Shaffo FC, Grodzki AC, Schelegle ES, Lein PJ. The Organophosphorus Pesticide Chlorpyrifos Induces Sex-Specific Airway Hyperreactivity in Adult Rats. Toxicol Sci. 2018 09 01; 165(1):244-253. PMID: 29939342.
      View in: PubMed
    26. Keil KP, Miller GW, Chen H, Sethi S, Schmuck MR, Dhakal K, Kim JW, Lein PJ. PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms. Arch Toxicol. 2018 10; 92(10):3163-3173. PMID: 30132043.
      View in: PubMed
    27. Shaffo FC, Grodzki AC, Fryer AD, Lein PJ. Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma. Am J Physiol Lung Cell Mol Physiol. 2018 10 01; 315(4):L485-L501. PMID: 29952220.
      View in: PubMed
    28. Hampe AE, Li Z, Sethi S, Lein PJ, Seker E. A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films. Nanomaterials (Basel). 2018 Jun 21; 8(7). PMID: 29933551.
      View in: PubMed
    29. Miller GW, Chandrasekaran V, Yaghoobi B, Lein PJ. Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity. Neurotoxicology. 2018 07; 67:102-111. PMID: 29704525.
      View in: PubMed
    30. Frank DF, Miller GW, Harvey DJ, Brander SM, Geist J, Connon RE, Lein PJ. Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio). Aquat Toxicol. 2018 Jul; 200:50-61. PMID: 29727771.
      View in: PubMed
    31. Fritsche E, Grandjean P, Crofton KM, Aschner M, Goldberg A, Heinonen T, Hessel EVS, Hogberg HT, Bennekou SH, Lein PJ, Leist M, Mundy WR, Paparella M, Piersma AH, Sachana M, Schmuck G, Solecki R, Terron A, Monnet-Tschudi F, Wilks MF, Witters H, Zurich MG, Bal-Price A. Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes. Toxicol Appl Pharmacol. 2018 09 01; 354:3-6. PMID: 29447839.
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    32. Berg EL, Copping NA, Rivera JK, Pride MC, Careaga M, Bauman MD, Berman RF, Lein PJ, Harony-Nicolas H, Buxbaum JD, Ellegood J, Lerch JP, Wöhr M, Silverman JL. Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder. Autism Res. 2018 04; 11(4):587-601. PMID: 29377611.
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    33. Chen X, Walter KM, Miller GW, Lein PJ, Puschner B. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jun; 32(6):e4185. PMID: 29314156.
      View in: PubMed
    34. Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ. Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex. J Neuroinflammation. 2018 Jan 06; 15(1):7. PMID: 29306331.
      View in: PubMed
    35. Sethi S, Keil KP, Lein PJ. Species and Sex Differences in the Morphogenic Response of Primary Rodent Neurons to 3,3'-Dichlorobiphenyl (PCB 11). Toxics. 2017 Dec 23; 6(1). PMID: 29295518.
      View in: PubMed
    36. Frank DF, Miller GW, Connon RE, Geist J, Lein PJ. Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. PeerJ. 2017; 5:e4106. PMID: 29201571.
      View in: PubMed
    37. Hobson BA, Rowland DJ, Supasai S, Harvey DJ, Lein PJ, Garbow JR. A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication. Neurotoxicology. 2018 05; 66:170-178. PMID: 29183789.
      View in: PubMed
    38. Keil KP, Sethi S, Wilson MD, Chen H, Lein PJ. In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons. Sci Rep. 2017 08 16; 7(1):8486. PMID: 28814778.
      View in: PubMed
    39. Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler HJ, Puschner B, Lein PJ. Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons. Toxicol Sci. 2017 08 01; 158(2):401-411. PMID: 28510766.
      View in: PubMed
    40. Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera S, Lein PJ, Lehmler HJ. Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity. Toxicol Sci. 2017 07 01; 158(1):101-115. PMID: 28431184.
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    41. Mengeling BJ, Wei Y, Dobrawa LN, Streekstra M, Louisse J, Singh V, Singh L, Lein PJ, Wulff H, Murk AJ, Furlow JD. A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling. Aquat Toxicol. 2017 Sep; 190:1-10. PMID: 28662416.
      View in: PubMed
    42. Sisó S, Hobson BA, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ. Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate. Toxicol Sci. 2017 06 01; 157(2):330-341. PMID: 28329845.
      View in: PubMed
    43. Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ. From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate. Toxicol Sci. 2017 06 01; 157(2):342-353. PMID: 28329842.
      View in: PubMed
    44. Chen H, Judkins J, Thomas C, Wu M, Khoury L, Benjamin CG, Pacione D, Golfinos JG, Kumthekar P, Ghamsari F, Chen L, Lein P, Chetkovich DM, Snuderl M, Horbinski C. Mutant IDH1 and seizures in patients with glioma. Neurology. 2017 May 09; 88(19):1805-1813. PMID: 28404805.
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    45. Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ. From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms. Toxicol Sci. 2017 04 01; 156(2):375-386. PMID: 28003438.
      View in: PubMed
    46. Chapman CA, Zhu X, Chen H, Yanik AA, Lein PJ, Seker E. Nanostructure Introduces Artifacts in Quantitative Immunofluorescence by Influencing Fluorophore Intensity. Sci Rep. 2017 03 27; 7(1):427. PMID: 28348397.
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    47. Dach K, Bendt F, Huebenthal U, Giersiefer S, Lein PJ, Heuer H, Fritsche E. BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action. Sci Rep. 2017 03 20; 7:44861. PMID: 28317842.
      View in: PubMed
    48. van Thriel C, Levin E, Lein P, Costa LG, Westerink RH. Neural mechanisms of functional impairment across the lifespan: The 15th Biennial Meeting of the International Neurotoxicology Association and 39th Annual Meeting of the Neurobehavioral Teratology Society. Neurotoxicology. 2017 03; 59:131-132. PMID: 28347437.
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    49. Dunaway K, Goorha S, Matelski L, Urraca N, Lein PJ, Korf I, Reiter LT, LaSalle JM. Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns. Stem Cells. 2017 04; 35(4):981-988. PMID: 28032673.
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    50. Voorhees JR, Rohlman DS, Lein PJ, Pieper AA. Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds. Front Neurosci. 2016; 10:590. PMID: 28149268.
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    51. Wilson MD, Sethi S, Lein PJ, Keil KP. Valid statistical approaches for analyzing sholl data: Mixed effects versus simple linear models. J Neurosci Methods. 2017 03 01; 279:33-43. PMID: 28104486.
      View in: PubMed
    52. Chapman CAR, Wang L, Chen H, Garrison J, Lein PJ, Seker E. Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance. Adv Funct Mater. 2017 Jan 19; 27(3). PMID: 28626362.
      View in: PubMed
    53. Flannery BM, Bruun DA, Rowland DJ, Banks CN, Austin AT, Kukis DL, Li Y, Ford BD, Tancredi DJ, Silverman JL, Cherry SR, Lein PJ. Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication. J Neuroinflammation. 2016 10 12; 13(1):267. PMID: 27733171.
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    54. Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ. Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents. Ann N Y Acad Sci. 2016 08; 1378(1):124-136. PMID: 27467073.
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    55. Aschner M, Ceccatelli S, Daneshian M, Fritsche E, Hasiwa N, Hartung T, Hogberg HT, Leist M, Li A, Mundi WR, Padilla S, Piersma AH, Bal-Price A, Seiler A, Westerink RH, Zimmer B, Lein PJ. Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use. ALTEX. 2017; 34(1):49-74. PMID: 27452664.
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    56. Chapman CA, Chen H, Stamou M, Lein PJ, Seker E. Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces. Cell Mol Bioeng. 2016 Sep; 9(3):433-442. PMID: 27795742.
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    57. Bal-Price A, Lein PJ, Keil KP, Sethi S, Shafer T, Barenys M, Fritsche E, Sachana M, Meek MEB. Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity. Neurotoxicology. 2017 03; 59:240-255. PMID: 27212452.
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    58. Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V. Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity. J Org Chem. 2016 Mar 04; 81(5):1870-6. PMID: 26849160.
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    59. Keil KP, Lein PJ. DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? Environ Epigenet. 2016 Mar; 2(1). PMID: 27158529.
      View in: PubMed
    60. Courter LA, Shaffo FC, Ghogha A, Parrish DJ, Lorentz CU, Habecker BA, Lein PJ. BMP7-induced dendritic growth in sympathetic neurons requires p75(NTR) signaling. Dev Neurobiol. 2016 09; 76(9):1003-13. PMID: 26663679.
      View in: PubMed
    61. Saldarriaga W, Lein P, González Teshima LY, Isaza C, Rosa L, Polyak A, Hagerman R, Girirajan S, Silva M, Tassone F. Phenobarbital use and neurological problems in FMR1 premutation carriers. Neurotoxicology. 2016 Mar; 53:141-147. PMID: 26802682.
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    62. Lee YS, Lewis JA, Ippolito DL, Hussainzada N, Lein PJ, Jackson DA, Stallings JD. Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides. Toxicology. 2016 Jan 18; 340:53-62. PMID: 26775027.
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    63. Proskocil BJ, Bruun DA, Garg JA, Villagomez CC, Jacoby DB, Lein PJ, Fryer AD. The influence of sensitization on mechanisms of organophosphorus pesticide-induced airway hyperreactivity. Am J Respir Cell Mol Biol. 2015 Nov; 53(5):738-47. PMID: 25897622.
      View in: PubMed
    64. Bui-Nguyen TM, Baer CE, Lewis JA, Yang D, Lein PJ, Jackson DA. Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio. BMC Genomics. 2015 Oct 24; 16:853. PMID: 26499117.
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    65. Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler HJ, Lein PJ. Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. Toxicology. 2015 Dec 02; 338:59-68. PMID: 26463278.
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    66. Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler HJ. Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice. Chem Res Toxicol. 2015 Sep 21; 28(9):1774-83. PMID: 26271003.
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    67. Chandrasekaran V, Lea C, Sosa JC, Higgins D, Lein PJ. Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons. Mol Cell Neurosci. 2015 Jul; 67:116-25. PMID: 26079955.
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    68. Barnhart CD, Yang D, Lein PJ. Using the Morris water maze to assess spatial learning and memory in weanling mice. PLoS One. 2015; 10(4):e0124521. PMID: 25886563.
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    69. Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ. Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. Neuropharmacology. 2015 Aug; 95:332-42. PMID: 25882826.
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    70. Li Y, Lein PJ, Ford GD, Liu C, Stovall KC, White TE, Bruun DA, Tewolde T, Gates AS, Distel TJ, Surles-Zeigler MC, Ford BD. Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury. J Neuroinflammation. 2015 Apr 02; 12:64. PMID: 25880399.
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    71. Chapman CA, Chen H, Stamou M, Biener J, Biener MM, Lein PJ, Seker E. Nanoporous gold as a neural interface coating: effects of topography, surface chemistry, and feature size. ACS Appl Mater Interfaces. 2015 Apr 08; 7(13):7093-100. PMID: 25706691.
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    72. Harrill JA, Chen H, Streifel KM, Yang D, Mundy WR, Lein PJ. Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons. Mol Brain. 2015 Feb 15; 8:10. PMID: 25757474.
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    73. Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN. Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture. Mol Pharmacol. 2015 Apr; 87(4):595-605. PMID: 25583085.
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    74. Bal-Price A, Crofton KM, Sachana M, Shafer TJ, Behl M, Forsby A, Hargreaves A, Landesmann B, Lein PJ, Louisse J, Monnet-Tschudi F, Paini A, Rolaki A, Schrattenholz A, Suñol C, van Thriel C, Whelan M, Fritsche E. Putative adverse outcome pathways relevant to neurotoxicity. Crit Rev Toxicol. 2015 Jan; 45(1):83-91. PMID: 25605028.
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    75. Grodzki AC, Poola B, Pasupuleti N, Nantz MH, Lein PJ, Gorin F. A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor a and interleukin-1ß expression. J Pharmacol Exp Ther. 2015 Mar; 352(3):438-47. PMID: 25538105.
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    76. Wu X, Barnhart C, Lein PJ, Lehmler HJ. Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice. Environ Sci Technol. 2015 Jan 06; 49(1):616-25. PMID: 25420130.
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    77. Haudenschild DR, Eldridge A, Lein PJ, Chromy BA. High abundant protein removal from rodent blood for biomarker discovery. Biochem Biophys Res Commun. 2014 Dec 05; 455(1-2):84-9. PMID: 25445603.
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    78. Levoe SN, Flannery BM, Brignolo L, Imai DM, Koehne A, Austin AT, Bruun DA, Tancredi DJ, Lein PJ. Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior. Curr Neurobiol. 2014 Dec 01; 5(1-2):1-10. PMID: 25705100.
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    79. Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ. Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine. Neurotoxicol Teratol. 2015 Jan-Feb; 47:36-45. PMID: 25446016.
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    80. Singleton ST, Lein PJ, Dadson OA, McGarrigle BP, Farahat FM, Farahat T, Bonner MR, Fenske RA, Galvin K, Lasarev MR, Anger WK, Rohlman DS, Olson JR. Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers. Int J Hyg Environ Health. 2015 Mar; 218(2):203-11. PMID: 25466362.
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    81. Vito ST, Austin AT, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ. Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication. Toxicol Appl Pharmacol. 2014 Dec 01; 281(2):185-94. PMID: 25448683.
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    82. Moore CE, Lein PJ, Puschner B. Microcystins alter chemotactic behavior in Caenorhabditis elegans by selectively targeting the AWA sensory neuron. Toxins (Basel). 2014 Jun 10; 6(6):1813-36. PMID: 24918360.
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    83. Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ, Wayman GA. The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. J Neurosci. 2014 Jan 15; 34(3):717-25. PMID: 24431430.
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    84. Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci. 2014 Apr; 138(2):379-92. PMID: 24385416.
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    85. Stamou M, Wu X, Kania-Korwel I, Lehmler HJ, Lein PJ. Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences. Drug Metab Dispos. 2014 Feb; 42(2):239-44. PMID: 24255117.
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    86. Singleton ST, Lein PJ, Farahat FM, Farahat T, Bonner MR, Knaak JB, Olson JR. Characterization of a-cypermethrin exposure in Egyptian agricultural workers. Int J Hyg Environ Health. 2014 Apr-May; 217(4-5):538-45. PMID: 24269189.
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    87. Wu X, Kania-Korwel I, Chen H, Stamou M, Dammanahalli KJ, Duffel M, Lein PJ, Lehmler HJ. Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent. Xenobiotica. 2013 Nov; 43(11):933-47. PMID: 23581876.
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    88. Dadson OA, Ellison CA, Singleton ST, Chi LH, McGarrigle BP, Lein PJ, Farahat FM, Farahat T, Olson JR. Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker. Toxicology. 2013 Apr 05; 306:35-9. PMID: 23415833.
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    89. Proskocil BJ, Bruun DA, Jacoby DB, van Rooijen N, Lein PJ, Fryer AD. Macrophage TNF-a mediates parathion-induced airway hyperreactivity in guinea pigs. Am J Physiol Lung Cell Mol Physiol. 2013 Apr 15; 304(8):L519-29. PMID: 23377347.
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    90. Grodzki AC, Giulivi C, Lein PJ. Oxygen tension modulates differentiation and primary macrophage functions in the human monocytic THP-1 cell line. PLoS One. 2013; 8(1):e54926. PMID: 23355903.
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    91. Stamou M, Streifel KM, Goines PE, Lein PJ. Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders. Neurotoxicol Teratol. 2013 Mar-Apr; 36:3-16. PMID: 23269408.
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    92. Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler HJ. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol. 2012 Oct 16; 46(20):11393-401. PMID: 22974126.
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    93. Ellison CA, Crane AL, Bonner MR, Knaak JB, Browne RW, Lein PJ, Olson JR. PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos. Toxicol Appl Pharmacol. 2012 Dec 15; 265(3):308-15. PMID: 22975224.
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    94. Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN. Tetramethylenedisulfotetramine alters Ca²? dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicol Sci. 2012 Dec; 130(2):362-72. PMID: 22889812.
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    95. Liu C, Li Y, Lein PJ, Ford BD. Spatiotemporal patterns of GFAP upregulation in rat brain following acute intoxication with diisopropylfluorophosphate (DFP). Curr Neurobiol. 2012 Jul; 3(2):90-97. PMID: 24039349.
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    96. Li Y, Lein PJ, Liu C, Bruun DA, Giulivi C, Ford GD, Tewolde T, Ross-Inta C, Ford BD. Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury. Toxicol Appl Pharmacol. 2012 Jul 15; 262(2):194-204. PMID: 22583949.
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    97. Wayman GA, Bose DD, Yang D, Lesiak A, Bruun D, Impey S, Ledoux V, Pessah IN, Lein PJ. PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. Environ Health Perspect. 2012 Jul; 120(7):1003-9. PMID: 22534176.
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    98. Wayman GA, Yang D, Bose DD, Lesiak A, Ledoux V, Bruun D, Pessah IN, Lein PJ. PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environ Health Perspect. 2012 Jul; 120(7):997-1002. PMID: 22534141.
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    99. Lein PJ. Emerging concepts in neurotoxicology: models, mechanisms and modifying factors. Neurotoxicology. 2012 Jun; 33(3):516-7. PMID: 22694846.
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    100. Ghogha A, Bruun DA, Lein PJ. Inducing dendritic growth in cultured sympathetic neurons. J Vis Exp. 2012 Mar 21; (61). PMID: 22473299.
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    101. Banks CN, Lein PJ. A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation. Neurotoxicology. 2012 Jun; 33(3):575-84. PMID: 22342984.
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    102. Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA. Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. J Pharmacol Exp Ther. 2012 May; 341(2):435-46. PMID: 22328574.
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    103. Lein PJ, Bonner MR, Farahat FM, Olson JR, Rohlman DS, Fenske RA, Lattal KM, Lasarev MR, Galvin K, Farahat TM, Anger WK. Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos. Neurotoxicology. 2012 Aug; 33(4):660-8. PMID: 22240005.
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    104. Bal-Price AK, Coecke S, Costa L, Crofton KM, Fritsche E, Goldberg A, Grandjean P, Lein PJ, Li A, Lucchini R, Mundy WR, Padilla S, Persico AM, Seiler AE, Kreysa J. Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. ALTEX. 2012; 29(2):202-15. PMID: 22892558.
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    105. Ellison CA, Abou El-Ella SS, Tawfik M, Lein PJ, Olson JR. Allele and genotype frequencies of CYP2B6 and CYP2C19 polymorphisms in Egyptian agricultural workers. J Toxicol Environ Health A. 2012; 75(4):232-41. PMID: 22352331.
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    106. van Thriel C, Westerink RH, Beste C, Bale AS, Lein PJ, Leist M. Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts. Neurotoxicology. 2012 Aug; 33(4):911-24. PMID: 22008243.
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    107. Garred MM, Wang MM, Guo X, Harrington CA, Lein PJ. Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth. PLoS One. 2011; 6(7):e21754. PMID: 21765909.
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    108. Ellison CA, Smith JN, Lein PJ, Olson JR. Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos. Toxicology. 2011 Sep 05; 287(1-3):137-44. PMID: 21708215.
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    109. Li Y, Lein PJ, Liu C, Bruun DA, Tewolde T, Ford G, Ford BD. Spatiotemporal pattern of neuronal injury induced by DFP in rats: a model for delayed neuronal cell death following acute OP intoxication. Toxicol Appl Pharmacol. 2011 Jun 15; 253(3):261-9. PMID: 21513723.
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    110. Grodzki AC, Ghogha A, Mangini L, Fryer AD, Lein PJ. IFN? Increases M2 Muscarinic Receptor Expression in Cultured Sympathetic Neurons. Curr Neurobiol. 2011 Apr; 2(1):23-29. PMID: 23226931.
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    111. Yang D, Lauridsen H, Buels K, Chi LH, La Du J, Bruun DA, Olson JR, Tanguay RL, Lein PJ. Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior. Toxicol Sci. 2011 May; 121(1):146-59. PMID: 21346248.
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    112. Abdu E, Bruun DA, Yang D, Yang J, Inceoglu B, Hammock BD, Alkayed NJ, Lein PJ. Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures. J Neurochem. 2011 May; 117(4):632-42. PMID: 21155804.
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    113. Farahat FM, Ellison CA, Bonner MR, McGarrigle BP, Crane AL, Fenske RA, Lasarev MR, Rohlman DS, Anger WK, Lein PJ, Olson JR. Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers. Environ Health Perspect. 2011 Jun; 119(6):801-6. PMID: 21224175.
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    114. Lein PJ, Barnhart CD, Pessah IN. Acute hippocampal slice preparation and hippocampal slice cultures. Methods Mol Biol. 2011; 758:115-34. PMID: 21815062.
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    115. Crofton KM, Mundy WR, Lein PJ, Bal-Price A, Coecke S, Seiler AE, Knaut H, Buzanska L, Goldberg A. Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals. ALTEX. 2011; 28(1):9-15. PMID: 21311847.
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    116. Rohlman DS, Anger WK, Lein PJ. Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure. Neurotoxicology. 2011 Mar; 32(2):268-76. PMID: 21182866.
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    117. Kim KH, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, Pessah IN. Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity. Environ Health Perspect. 2011 Apr; 119(4):519-26. PMID: 21106467.
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    118. Yang D, Bruun D, Andres DA, Lein PJ. Method for Shipping Live Cultures of Dissociated Rat Hippocampal Neurons. Curr Neurobiol. 2010 Oct; 1(2):95-98. PMID: 24052689.
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    119. Proskocil BJ, Bruun DA, Thompson CM, Fryer AD, Lein PJ. Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms. PLoS One. 2010 May 10; 5(5):e10562. PMID: 20479945.
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    120. Farahat FM, Fenske RA, Olson JR, Galvin K, Bonner MR, Rohlman DS, Farahat TM, Lein PJ, Anger WK. Chlorpyrifos exposures in Egyptian cotton field workers. Neurotoxicology. 2010 Jun; 31(3):297-304. PMID: 20193710.
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    121. Yang D, Lein PJ. Polychlorinated biphenyls increase apoptosis in the developing rat brain. Curr Neurobiol. 2010 Mar; 1(1):70-76. PMID: 24052688.
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    122. Pessah IN, Cherednichenko G, Lein PJ. Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacol Ther. 2010 Feb; 125(2):260-85. PMID: 19931307.
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    123. Halladay AK, Amaral D, Aschner M, Bolivar VJ, Bowman A, DiCicco-Bloom E, Hyman SL, Keller F, Lein P, Pessah I, Restifo L, Threadgill DW. Animal models of autism spectrum disorders: information for neurotoxicologists. Neurotoxicology. 2009 Sep; 30(5):811-21. PMID: 19596370.
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    124. Kim WY, Gonsiorek EA, Barnhart C, Davare MA, Engebose AJ, Lauridsen H, Bruun D, Lesiak A, Wayman G, Bucelli R, Higgins D, Lein PJ. Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. J Neurochem. 2009 Feb; 108(4):1057-71. PMID: 19209406.
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    125. Andres DA, Shi GX, Bruun D, Barnhart C, Lein PJ. Rit signaling contributes to interferon-gamma-induced dendritic retraction via p38 mitogen-activated protein kinase activation. J Neurochem. 2008 Dec; 107(5):1436-47. PMID: 18957053.
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    126. Yang D, Kim KH, Phimister A, Bachstetter AD, Ward TR, Stackman RW, Mervis RF, Wisniewski AB, Klein SL, Kodavanti PR, Anderson KA, Wayman G, Pessah IN, Lein PJ. Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. Environ Health Perspect. 2009 Mar; 117(3):426-35. PMID: 19337518.
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    127. Boswell BA, Lein PJ, Musil LS. Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells. Mol Biol Cell. 2008 Jun; 19(6):2631-41. PMID: 18400943.
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    128. Dziennis S, Yang D, Cheng J, Anderson KA, Alkayed NJ, Hurn PD, Lein PJ. Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats. Environ Health Perspect. 2008 Apr; 116(4):474-80. PMID: 18414629.
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    129. Proskocil BJ, Bruun DA, Lorton JK, Blensly KC, Jacoby DB, Lein PJ, Fryer AD. Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity. Environ Health Perspect. 2008 Mar; 116(3):381-8. PMID: 18335107.
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    130. Pessah IN, Seegal RF, Lein PJ, LaSalle J, Yee BK, Van De Water J, Berman RF. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology. 2008 May; 29(3):532-45. PMID: 18394707.
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    131. Bucelli RC, Gonsiorek EA, Kim WY, Bruun D, Rabin RA, Higgins D, Lein PJ. Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons. J Pharmacol Exp Ther. 2008 Mar; 324(3):1172-80. PMID: 18079356.
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    132. Yang D, Howard A, Bruun D, Ajua-Alemanj M, Pickart C, Lein PJ. Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Toxicol Appl Pharmacol. 2008 Apr 01; 228(1):32-41. PMID: 18076960.
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    133. Lein PJ, Guo X, Shi GX, Moholt-Siebert M, Bruun D, Andres DA. The novel GTPase Rit differentially regulates axonal and dendritic growth. J Neurosci. 2007 Apr 25; 27(17):4725-36. PMID: 17460085.
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    134. Coecke S, Goldberg AM, Allen S, Buzanska L, Calamandrei G, Crofton K, Hareng L, Hartung T, Knaut H, Honegger P, Jacobs M, Lein P, Li A, Mundy W, Owen D, Schneider S, Silbergeld E, Reum T, Trnovec T, Monnet-Tschudi F, Bal-Price A. Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies. Environ Health Perspect. 2007 Jun; 115(6):924-31. PMID: 17589601.
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    135. Lein P, Locke P, Goldberg A. Meeting report: alternatives for developmental neurotoxicity testing. Environ Health Perspect. 2007 May; 115(5):764-8. PMID: 17520065.
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    136. Lein PJ, Yang D, Bachstetter AD, Tilson HA, Harry GJ, Mervis RF, Kodavanti PR. Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls. Environ Health Perspect. 2007 Apr; 115(4):556-63. PMID: 17450224.
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    137. Pin S, Chen H, Lein PJ, Wang MM. Nucleic acid binding agents exert local toxic effects on neurites via a non-nuclear mechanism. J Neurochem. 2006 Mar; 96(5):1253-66. PMID: 16441515.
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    138. Howard AS, Bucelli R, Jett DA, Bruun D, Yang D, Lein PJ. Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures. Toxicol Appl Pharmacol. 2005 Sep 01; 207(2):112-24. PMID: 16102564.
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    139. Lein P, Silbergeld E, Locke P, Goldberg AM. In vitro and other alternative approaches to developmental neurotoxicity testing (DNT). Environ Toxicol Pharmacol. 2005 May; 19(3):735-44. PMID: 21783550.
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    140. Lein PJ, Fryer AD. Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicol Sci. 2005 Jan; 83(1):166-76. PMID: 15470232.
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    141. Shen W, Finnegan S, Lein P, Sullivan S, Slaughter M, Higgins D. Bone morphogenetic proteins regulate ionotropic glutamate receptors in human retina. Eur J Neurosci. 2004 Oct; 20(8):2031-7. PMID: 15450082.
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    142. Kim IJ, Drahushuk KM, Kim WY, Gonsiorek EA, Lein P, Andres DA, Higgins D. Extracellular signal-regulated kinases regulate dendritic growth in rat sympathetic neurons. J Neurosci. 2004 Mar 31; 24(13):3304-12. PMID: 15056710.
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    143. Fryer AD, Lein PJ, Howard AS, Yost BL, Beckles RA, Jett DA. Mechanisms of organophosphate insecticide-induced airway hyperreactivity. Am J Physiol Lung Cell Mol Physiol. 2004 May; 286(5):L963-9. PMID: 14704222.
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    144. Chen HL, Lein PJ, Wang JY, Gash D, Hoffer BJ, Chiang YH. Expression of bone morphogenetic proteins in the brain during normal aging and in 6-hydroxydopamine-lesioned animals. Brain Res. 2003 Dec 19; 994(1):81-90. PMID: 14642451.
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    145. Howard AS, Fitzpatrick R, Pessah I, Kostyniak P, Lein PJ. Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor. Toxicol Appl Pharmacol. 2003 Jul 01; 190(1):72-86. PMID: 12831785.
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    146. Chang CF, Lin SZ, Chiang YH, Morales M, Chou J, Lein P, Chen HL, Hoffer BJ, Wang Y. Intravenous administration of bone morphogenetic protein-7 after ischemia improves motor function in stroke rats. Stroke. 2003 Feb; 34(2):558-64. PMID: 12574575.
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    147. Lein PJ, Beck HN, Chandrasekaran V, Gallagher PJ, Chen HL, Lin Y, Guo X, Kaplan PL, Tiedge H, Higgins D. Glia induce dendritic growth in cultured sympathetic neurons by modulating the balance between bone morphogenetic proteins (BMPs) and BMP antagonists. J Neurosci. 2002 Dec 01; 22(23):10377-87. PMID: 12451137.
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    148. Schuh RA, Lein PJ, Beckles RA, Jett DA. Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons. Toxicol Appl Pharmacol. 2002 Jul 15; 182(2):176-85. PMID: 12140181.
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    149. Roth JA, Horbinski C, Higgins D, Lein P, Garrick MD. Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. Neurotoxicology. 2002 Jul; 23(2):147-57. PMID: 12224755.
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    150. Kim IJ, Beck HN, Lein PJ, Higgins D. Interferon gamma induces retrograde dendritic retraction and inhibits synapse formation. J Neurosci. 2002 Jun 01; 22(11):4530-9. PMID: 12040060.
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    151. Dattatreyamurty B, Roux E, Horbinski C, Kaplan PL, Robak LA, Beck HN, Lein P, Higgins D, Chandrasekaran V. Cerebrospinal fluid contains biologically active bone morphogenetic protein-7. Exp Neurol. 2001 Dec; 172(2):273-81. PMID: 11716552.
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    152. Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ. Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. BMC Neurosci. 2001; 2:12. PMID: 11580864.
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    153. Guo X, Lin Y, Horbinski C, Drahushuk KM, Kim IJ, Kaplan PL, Lein P, Wang T, Higgins D. Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity. J Neurobiol. 2001 Aug; 48(2):120-30. PMID: 11438941.
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    154. Lein P, Gallagher PJ, Amodeo J, Howie H, Roth JA. Manganese induces neurite outgrowth in PC12 cells via upregulation of alpha(v) integrins. Brain Res. 2000 Dec 08; 885(2):220-30. PMID: 11102576.
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    155. Guo X, Chandrasekaran V, Lein P, Kaplan PL, Higgins D. Leukemia inhibitory factor and ciliary neurotrophic factor cause dendritic retraction in cultured rat sympathetic neurons. J Neurosci. 1999 Mar 15; 19(6):2113-21. PMID: 10066264.
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    156. Gadient RA, Lein P, Higgins D, Patterson PH. Effect of leukemia inhibitory factor (LIF) on the morphology and survival of cultured hippocampal neurons and glial cells. Brain Res. 1998 Jul 06; 798(1-2):140-6. PMID: 9666105.
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    157. Guo X, Metzler-Northrup J, Lein P, Rueger D, Higgins D. Leukemia inhibitory factor and ciliary neurotrophic factor regulate dendritic growth in cultures of rat sympathetic neurons. Brain Res Dev Brain Res. 1997 Dec 19; 104(1-2):101-10. PMID: 9466712.
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    158. Higgins D, Burack M, Lein P, Banker G. Mechanisms of neuronal polarity. Curr Opin Neurobiol. 1997 Oct; 7(5):599-604. PMID: 9384542.
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    159. Lein P, Guo X, Hedges AM, Rueger D, Johnson M, Higgins D. The effects of extracellular matrix and osteogenic protein-1 on the morphological differentiation of rat sympathetic neurons. Int J Dev Neurosci. 1996 Jun; 14(3):203-15. PMID: 8842799.
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    160. Lein P, Higgins D. Antibodies to ß1 integrins inhibit dendritic growth in rat sympathetic neurons. Biomed Res (Aligarh). 1996; 7(1):101-111. PMID: 29238133.
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    161. Lein P, Johnson M, Guo X, Rueger D, Higgins D. Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons. Neuron. 1995 Sep; 15(3):597-605. PMID: 7546739.
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    162. Lein PJ, Banker GA, Higgins D. Laminin selectively enhances axonal growth and accelerates the development of polarity by hippocampal neurons in culture. Brain Res Dev Brain Res. 1992 Oct 23; 69(2):191-7. PMID: 1424096.
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    163. Lein PJ, Higgins D. Protein synthesis is required for the initiation of dendritic growth in embryonic rat sympathetic neurons in vitro. Brain Res Dev Brain Res. 1991 Jun 21; 60(2):187-96. PMID: 1716531.
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    164. Lein PJ, Higgins D, Turner DC, Flier LA, Terranova VP. The NC1 domain of type IV collagen promotes axonal growth in sympathetic neurons through interaction with the alpha 1 beta 1 integrin. J Cell Biol. 1991 Apr; 113(2):417-28. PMID: 2010469.
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    165. Bruckenstein DA, Lein PJ, Higgins D, Fremeau RT. Distinct spatial localization of specific mRNAs in cultured sympathetic neurons. Neuron. 1990 Dec; 5(6):809-19. PMID: 2148487.
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    166. Lein PJ, Higgins D. Laminin and a basement membrane extract have different effects on axonal and dendritic outgrowth from embryonic rat sympathetic neurons in vitro. Dev Biol. 1989 Dec; 136(2):330-45. PMID: 2479584.
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    167. Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Lein PJ, Roth JA. Effect of short-term exposure to hexachlorophene on rat brain cell specific marker enzymes. Fundam Appl Toxicol. 1988 Oct; 11(3):519-27. PMID: 2906023.
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    168. Pancorbo OC, Lein PJ, Blevins RD. Mutagenic activity of surface waters adjacent to a nuclear fuel processing facility. Arch Environ Contam Toxicol. 1987 Sep; 16(5):531-7. PMID: 3632040.
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