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Pamela J Lein

TitleAssociate Professor
InstitutionUniversity of California Davis
DepartmentMolecular Biosciences
Address2009 Vet Med 3B
CA 95616
Phone530-752-1970
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    Collapse Research 
    Collapse Research Activities and Funding
    PCB Epigenomic Brain & Behavior Lasting Effects Study (PEBBLES)
    NIH/NIEHS R01ES029213Jun 1, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Vascular Inflammation and Exosomes as Mediators in Aging and Dementia
    NIH/NIA R01AG056710Mar 15, 2018 - Feb 28, 2023
    Role: Co-Principal Investigator
    Does air pollution increase risk of AD in a genetically susceptible animal model?
    NIH/NIEHS R21ES026515Jun 1, 2016 - May 31, 2018
    Role: Principal Investigator
    Novel Anticonvulsant and Neuroprotective Therapies for TETS and OP Intoxication
    NIH/NINDS U54NS079202Sep 1, 2012 - May 31, 2022
    Role: Principal Investigator
    Identification of novel therapeutic approaches for TETS and OP intoxication
    NIH/NINDS R21NS072094Sep 30, 2010 - Aug 31, 2013
    Role: Principal Investigator
    Role of macrophages in organophosphorus pesticide-induced airway hyperreactivity
    NIH/NIEHS R01ES017592Jul 7, 2010 - Apr 30, 2015
    Role: Principal Investigator
    Enantioselective Metabolism Influences PCB Developmental Neurotoxicity
    NIH/NIEHS R01ES017425Jan 26, 2010 - Dec 31, 2015
    Role: Co-Principal Investigator
    Biomarkers of Organophosphorus Pesticide-Induced Neurotoxicity
    NIH/NIEHS R01ES016308Jun 1, 2008 - Apr 30, 2013
    Role: Co-Principal Investigator
    Molecular and Cellular Basis of PCB Developmental Neurotoxicity
    NIH/NIEHS R56ES014901Aug 1, 2007 - Jul 31, 2008
    Role: Principal Investigator
    Molecular and Cellular Basis of PCB Developmental Neurotoxicity
    NIH/NIEHS R01ES014901Jul 1, 2006 - Nov 30, 2019
    Role: Principal Investigator
    Molecular Regulation of Primary Dendritogenesis
    NIH/NINDS R21NS045037Jan 15, 2004 - Dec 31, 2006
    Role: Principal Investigator
    Retrograde Dystrophic Influence of IFN-gamma on Neurons
    NIH/NINDS R01NS046649Jul 16, 2003 - Apr 30, 2009
    Role: Principal Investigator
    Mechanism of organophosphate development neurotoxicity
    NIH/NIEHS R21ES011771Mar 15, 2002 - Jul 31, 2005
    Role: Principal Investigator
    Do PCBs alter developing brain structure and cognition?
    NIH/NICHD R03HD040936Mar 15, 2002 - Aug 31, 2004
    Role: Principal Investigator
    REGULATION OF DENDRITIC GROWTH BY OSTEOGENIC PROTEIN-1
    NIH/NINDS R15NS036401May 15, 1997 - Apr 30, 2000
    Role: Principal Investigator
    CELL BIOLOGY OF HUMAN TILS ENGRAFTED INTO SCID MICE
    NIH/NCI F32CA009177Feb 19, 1992
    Role: Principal Investigator
    Advanced Training in Environmental Health Sciences
    NIH/NIEHS T32ES007059Jul 1, 1978 - Jun 30, 2023
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Walter KM, Miller GW, Chen X, Yaghoobi B, Puschner B, Lein PJ. Effects of Thyroid Hormone Disruption on the Ontogenetic Expression of Thyroid Hormone Signaling Genes in Developing Zebrafish (Danio rerio). Gen Comp Endocrinol. 2018 Nov 15. PMID: 30448381.
      View in: PubMed
    2. Keil KP, Sethi S, Lein PJ. Sex-dependent effects of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) on dendritic arborization of primary mouse neurons. Toxicol Sci. 2018 Nov 03. PMID: 30395321.
      View in: PubMed
    3. Dach K, Yaghoobi B, Schmuck MR, Carty DR, Morales KM, Lein PJ. Teratological and behavioral screening of the National Toxicology Program 91-compound library in zebrafish (Danio rerio). Toxicol Sci. 2018 Oct 26. PMID: 30364989.
      View in: PubMed
    4. Frank DF, Brander SM, Hasenbein S, Harvey DJ, Lein PJ, Geist J, Connon RE. Developmental exposure to environmentally relevant concentrations of bifenthrin alters transcription of mTOR and ryanodine receptor-dependent signaling molecules and impairs predator avoidance behavior across early life stages in inland silversides (Menidia beryllina). Aquat Toxicol. 2018 Oct 24; 206:1-13. PMID: 30414561.
      View in: PubMed
    5. Keil KP, Sethi S, Wilson MD, Silverman JL, Pessah IN, Lein PJ. Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice. Genes Brain Behav. 2018 Oct 12; e12526. PMID: 30311737.
      View in: PubMed
    6. González EA, Carty DR, Tran FD, Cole AM, Lein PJ. Developmental Exposure to Silver Nanoparticles at Environmentally Relevant Concentrations Alters Swimming Behavior in Zebrafish (Danio rerio). Environ Toxicol Chem. 2018 Sep 22. PMID: 30242895.
      View in: PubMed
    7. Sethi S, Keil KP, Lein PJ. 3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. Arch Toxicol. 2018 Sep 17. PMID: 30225637.
      View in: PubMed
    8. Keil KP, Miller GW, Chen H, Sethi S, Schmuck MR, Dhakal K, Kim JW, Lein PJ. PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms. Arch Toxicol. 2018 Aug 21. PMID: 30132043.
      View in: PubMed
    9. Shaffo FC, Grodzki AC, Fryer AD, Lein PJ. Mechanisms of Organophosphorus Pesticide Toxicity in the Context of Airway Hyperreactivity and Asthma. Am J Physiol Lung Cell Mol Physiol. 2018 Jun 28. PMID: 29952220.
      View in: PubMed
    10. Shaffo FC, Grodzki AC, Schelegle ES, Lein PJ. The Organophosphorus Pesticide Chlorpyrifos Induces Sex-Specific Airway Hyperreactivity in Adult Rats. Toxicol Sci. 2018 Jun 25. PMID: 29939342.
      View in: PubMed
    11. Miller GW, Chandrasekaran V, Yaghoobi B, Lein PJ. Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity. Neurotoxicology. 2018 Apr 25; 67:102-111. PMID: 29704525.
      View in: PubMed
    12. Frank DF, Miller GW, Harvey DJ, Brander SM, Geist J, Connon RE, Lein PJ. Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio). Aquat Toxicol. 2018 Apr 18; 200:50-61. PMID: 29727771.
      View in: PubMed
    13. Berg EL, Copping NA, Rivera JK, Pride MC, Careaga M, Bauman MD, Berman RF, Lein PJ, Harony-Nicolas H, Buxbaum JD, Ellegood J, Lerch JP, Wöhr M, Silverman JL. Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder. Autism Res. 2018 Apr; 11(4):587-601. PMID: 29377611.
      View in: PubMed
    14. Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ. Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex. J Neuroinflammation. 2018 Jan 06; 15(1):7. PMID: 29306331.
      View in: PubMed
    15. Chen X, Walter KM, Miller GW, Lein PJ, Puschner B. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jan 03. PMID: 29314156.
      View in: PubMed
    16. Sethi S, Keil KP, Lein PJ. Species and Sex Differences in the Morphogenic Response of Primary Rodent Neurons to 3,3'-Dichlorobiphenyl (PCB 11). Toxics. 2017 Dec 23; 6(1). PMID: 29295518.
      View in: PubMed
    17. Frank DF, Miller GW, Connon RE, Geist J, Lein PJ. Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. PeerJ. 2017; 5:e4106. PMID: 29201571.
      View in: PubMed
    18. Hobson BA, Rowland DJ, Supasai S, Harvey DJ, Lein PJ, Garbow JR. A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication. Neurotoxicology. 2018 May; 66:170-178. PMID: 29183789.
      View in: PubMed
    19. Keil KP, Sethi S, Wilson MD, Chen H, Lein PJ. In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons. Sci Rep. 2017 08 16; 7(1):8486. PMID: 28814778.
      View in: PubMed
    20. Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler HJ, Puschner B, Lein PJ. Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons. Toxicol Sci. 2017 Aug 01; 158(2):401-411. PMID: 28510766.
      View in: PubMed
    21. Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera S, Lein PJ, Lehmler HJ. Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity. Toxicol Sci. 2017 Jul 01; 158(1):101-115. PMID: 28431184.
      View in: PubMed
    22. Sisó S, Hobson BA, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ. Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate. Toxicol Sci. 2017 06 01; 157(2):330-341. PMID: 28329845.
      View in: PubMed
    23. Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ. From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate. Toxicol Sci. 2017 06 01; 157(2):342-353. PMID: 28329842.
      View in: PubMed
    24. Chen H, Judkins J, Thomas C, Wu M, Khoury L, Benjamin CG, Pacione D, Golfinos JG, Kumthekar P, Ghamsari F, Chen L, Lein P, Chetkovich DM, Snuderl M, Horbinski C. Mutant IDH1 and seizures in patients with glioma. Neurology. 2017 May 09; 88(19):1805-1813. PMID: 28404805.
      View in: PubMed
    25. Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ. From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms. Toxicol Sci. 2017 04 01; 156(2):375-386. PMID: 28003438.
      View in: PubMed
    26. Chapman CA, Zhu X, Chen H, Yanik AA, Lein PJ, Seker E. Nanostructure Introduces Artifacts in Quantitative Immunofluorescence by Influencing Fluorophore Intensity. Sci Rep. 2017 03 27; 7(1):427. PMID: 28348397.
      View in: PubMed
    27. van Thriel C, Levin E, Lein P, Costa LG, Westerink RH. Neural mechanisms of functional impairment across the lifespan: The 15th Biennial Meeting of the International Neurotoxicology Association and 39th Annual Meeting of the Neurobehavioral Teratology Society. Neurotoxicology. 2017 03; 59:131-132. PMID: 28347437.
      View in: PubMed
    28. Voorhees JR, Rohlman DS, Lein PJ, Pieper AA. Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds. Front Neurosci. 2016; 10:590. PMID: 28149268.
      View in: PubMed
    29. Wilson MD, Sethi S, Lein PJ, Keil KP. Valid statistical approaches for analyzing sholl data: Mixed effects versus simple linear models. J Neurosci Methods. 2017 Mar 01; 279:33-43. PMID: 28104486.
      View in: PubMed
    30. Chapman CAR, Wang L, Chen H, Garrison J, Lein PJ, Seker E. Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance. Adv Funct Mater. 2017 Jan 19; 27(3). PMID: 28626362.
      View in: PubMed
    31. Flannery BM, Bruun DA, Rowland DJ, Banks CN, Austin AT, Kukis DL, Li Y, Ford BD, Tancredi DJ, Silverman JL, Cherry SR, Lein PJ. Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication. J Neuroinflammation. 2016 10 12; 13(1):267. PMID: 27733171.
      View in: PubMed
    32. Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ. Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents. Ann N Y Acad Sci. 2016 08; 1378(1):124-136. PMID: 27467073.
      View in: PubMed
    33. Bal-Price A, Lein PJ, Keil KP, Sethi S, Shafer T, Barenys M, Fritsche E, Sachana M, Meek MEB. Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity. Neurotoxicology. 2017 03; 59:240-255. PMID: 27212452.
      View in: PubMed
    34. Keil KP, Lein PJ. DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? Environ Epigenet. 2016 Mar; 2(1). PMID: 27158529.
      View in: PubMed
    35. Saldarriaga W, Lein P, González Teshima LY, Isaza C, Rosa L, Polyak A, Hagerman R, Girirajan S, Silva M, Tassone F. Phenobarbital use and neurological problems in FMR1 premutation carriers. Neurotoxicology. 2016 Mar; 53:141-147. PMID: 26802682; PMCID: PMC4808401.
    36. Lee YS, Lewis JA, Ippolito DL, Hussainzada N, Lein PJ, Jackson DA, Stallings JD. Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides. Toxicology. 2016 Jan 18; 340:53-62. PMID: 26775027; PMCID: PMC4777610 [Available on 01/18/17].
    37. Proskocil BJ, Bruun DA, Garg JA, Villagomez CC, Jacoby DB, Lein PJ, Fryer AD. The influence of sensitization on mechanisms of organophosphorus pesticide-induced airway hyperreactivity. Am J Respir Cell Mol Biol. 2015 Nov; 53(5):738-47. PMID: 25897622; PMCID: PMC4742952 [Available on 11/01/16].
    38. Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler HJ, Lein PJ. Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. Toxicology. 2015 Dec 02; 338:59-68. PMID: 26463278.
      View in: PubMed
    39. Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler HJ. Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice. Chem Res Toxicol. 2015 Sep 21; 28(9):1774-83. PMID: 26271003; PMCID: PMC4579038 [Available on 09/21/16].
    40. Barnhart CD, Yang D, Lein PJ. Using the Morris water maze to assess spatial learning and memory in weanling mice. PLoS One. 2015; 10(4):e0124521. PMID: 25886563.
      View in: PubMed
    41. Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ. Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. Neuropharmacology. 2015 Aug; 95:332-42. PMID: 25882826; PMCID: PMC4466064.
    42. Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN. Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture. Mol Pharmacol. 2015 Apr; 87(4):595-605. PMID: 25583085; PMCID: PMC4366799.
    43. Grodzki AC, Poola B, Pasupuleti N, Nantz MH, Lein PJ, Gorin F. A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor a and interleukin-1ß expression. J Pharmacol Exp Ther. 2015 Mar; 352(3):438-47. PMID: 25538105; PMCID: PMC4352593.
    44. Wu X, Barnhart C, Lein PJ, Lehmler HJ. Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice. Environ Sci Technol. 2015 Jan 06; 49(1):616-25. PMID: 25420130; PMCID: PMC4291784.
    45. Levoe SN, Flannery BM, Brignolo L, Imai DM, Koehne A, Austin AT, Bruun DA, Tancredi DJ, Lein PJ. Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior. Curr Neurobiol. 2014 Dec 01; 5(1-2):1-10. PMID: 25705100.
      View in: PubMed
    46. Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ. Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine. Neurotoxicol Teratol. 2015 Jan-Feb; 47:36-45. PMID: 25446016; PMCID: PMC4291292.
    47. Singleton ST, Lein PJ, Dadson OA, McGarrigle BP, Farahat FM, Farahat T, Bonner MR, Fenske RA, Galvin K, Lasarev MR, Anger WK, Rohlman DS, Olson JR. Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers. Int J Hyg Environ Health. 2015 Mar; 218(2):203-11. PMID: 25466362; PMCID: PMC4323691.
    48. Vito ST, Austin AT, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ. Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication. Toxicol Appl Pharmacol. 2014 Dec 01; 281(2):185-94. PMID: 25448683; PMCID: PMC4258121.
    49. Moore CE, Lein PJ, Puschner B. Microcystins alter chemotactic behavior in Caenorhabditis elegans by selectively targeting the AWA sensory neuron. Toxins (Basel). 2014 Jun 10; 6(6):1813-36. PMID: 24918360; PMCID: PMC4073131.
    50. Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ, Wayman GA. The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. J Neurosci. 2014 Jan 15; 34(3):717-25. PMID: 24431430; PMCID: PMC3891953.
    51. Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci. 2014 Apr; 138(2):379-92. PMID: 24385416; PMCID: PMC4007107.
    52. Stamou M, Wu X, Kania-Korwel I, Lehmler HJ, Lein PJ. Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences. Drug Metab Dispos. 2014 Feb; 42(2):239-44. PMID: 24255117; PMCID: PMC3912540.
    53. Singleton ST, Lein PJ, Farahat FM, Farahat T, Bonner MR, Knaak JB, Olson JR. Characterization of a-cypermethrin exposure in Egyptian agricultural workers. Int J Hyg Environ Health. 2014 Apr-May; 217(4-5):538-45. PMID: 24269189; PMCID: PMC3972299.
    54. Dadson OA, Ellison CA, Singleton ST, Chi LH, McGarrigle BP, Lein PJ, Farahat FM, Farahat T, Olson JR. Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker. Toxicology. 2013 Apr 05; 306:35-9. PMID: 23415833; PMCID: PMC4751995.
    55. Grodzki AC, Giulivi C, Lein PJ. Oxygen tension modulates differentiation and primary macrophage functions in the human monocytic THP-1 cell line. PLoS One. 2013; 8(1):e54926. PMID: 23355903; PMCID: PMC3552948.
    56. Stamou M, Streifel KM, Goines PE, Lein PJ. Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders. Neurotoxicol Teratol. 2013 Mar-Apr; 36:3-16. PMID: 23269408; PMCID: PMC3610799.
    57. Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler HJ. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol. 2012 Oct 16; 46(20):11393-401. PMID: 22974126; PMCID: PMC3475189.
    58. Ellison CA, Crane AL, Bonner MR, Knaak JB, Browne RW, Lein PJ, Olson JR. PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos. Toxicol Appl Pharmacol. 2012 Dec 15; 265(3):308-15. PMID: 22975224; PMCID: PMC3513664.
    59. Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN. Tetramethylenedisulfotetramine alters Ca²? dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicol Sci. 2012 Dec; 130(2):362-72. PMID: 22889812; PMCID: PMC3529644.
    60. Wayman GA, Bose DD, Yang D, Lesiak A, Bruun D, Impey S, Ledoux V, Pessah IN, Lein PJ. PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. Environ Health Perspect. 2012 Jul; 120(7):1003-9. PMID: 22534176; PMCID: PMC3404671.
    61. Wayman GA, Yang D, Bose DD, Lesiak A, Ledoux V, Bruun D, Pessah IN, Lein PJ. PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environ Health Perspect. 2012 Jul; 120(7):997-1002. PMID: 22534141; PMCID: PMC3404670.
    62. Lein PJ. Emerging concepts in neurotoxicology: models, mechanisms and modifying factors. Neurotoxicology. 2012 Jun; 33(3):516-7. PMID: 22694846.
      View in: PubMed
    63. Ghogha A, Bruun DA, Lein PJ. Inducing dendritic growth in cultured sympathetic neurons. J Vis Exp. 2012 Mar 21; (61). PMID: 22473299; PMCID: PMC3460579.
    64. Banks CN, Lein PJ. A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation. Neurotoxicology. 2012 Jun; 33(3):575-84. PMID: 22342984; PMCID: PMC3358519.
    65. Lein PJ, Bonner MR, Farahat FM, Olson JR, Rohlman DS, Fenske RA, Lattal KM, Lasarev MR, Galvin K, Farahat TM, Anger WK. Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos. Neurotoxicology. 2012 Aug; 33(4):660-8. PMID: 22240005; PMCID: PMC3332151.
    66. Ellison CA, Abou El-Ella SS, Tawfik M, Lein PJ, Olson JR. Allele and genotype frequencies of CYP2B6 and CYP2C19 polymorphisms in Egyptian agricultural workers. J Toxicol Environ Health A. 2012; 75(4):232-41. PMID: 22352331; PMCID: PMC3500531.
    67. van Thriel C, Westerink RH, Beste C, Bale AS, Lein PJ, Leist M. Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts. Neurotoxicology. 2012 Aug; 33(4):911-24. PMID: 22008243; PMCID: PMC3288589.
    68. Ellison CA, Smith JN, Lein PJ, Olson JR. Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos. Toxicology. 2011 Sep 05; 287(1-3):137-44. PMID: 21708215; PMCID: PMC3176336.
    69. Grodzki AC, Ghogha A, Mangini L, Fryer AD, Lein PJ. IFN? Increases M2 Muscarinic Receptor Expression in Cultured Sympathetic Neurons. Curr Neurobiol. 2011 Apr; 2(1):23-29. PMID: 23226931.
      View in: PubMed
    70. Yang D, Lauridsen H, Buels K, Chi LH, La Du J, Bruun DA, Olson JR, Tanguay RL, Lein PJ. Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior. Toxicol Sci. 2011 May; 121(1):146-59. PMID: 21346248; PMCID: PMC3080187.
    71. Farahat FM, Ellison CA, Bonner MR, McGarrigle BP, Crane AL, Fenske RA, Lasarev MR, Rohlman DS, Anger WK, Lein PJ, Olson JR. Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers. Environ Health Perspect. 2011 Jun; 119(6):801-6. PMID: 21224175; PMCID: PMC3114814.
    72. Lein PJ, Barnhart CD, Pessah IN. Acute hippocampal slice preparation and hippocampal slice cultures. Methods Mol Biol. 2011; 758:115-34. PMID: 21815062; PMCID: PMC3499947.
    73. Rohlman DS, Anger WK, Lein PJ. Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure. Neurotoxicology. 2011 Mar; 32(2):268-76. PMID: 21182866; PMCID: PMC3057226.
    74. Kim KH, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, Pessah IN. Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity. Environ Health Perspect. 2011 Apr; 119(4):519-26. PMID: 21106467; PMCID: PMC3080935.
    75. Yang D, Bruun D, Andres DA, Lein PJ. Method for Shipping Live Cultures of Dissociated Rat Hippocampal Neurons. Curr Neurobiol. 2010 Oct; 1(2):95-98. PMID: 24052689.
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    76. Farahat FM, Fenske RA, Olson JR, Galvin K, Bonner MR, Rohlman DS, Farahat TM, Lein PJ, Anger WK. Chlorpyrifos exposures in Egyptian cotton field workers. Neurotoxicology. 2010 Jun; 31(3):297-304. PMID: 20193710; PMCID: PMC3580798.
    77. Yang D, Lein PJ. Polychlorinated biphenyls increase apoptosis in the developing rat brain. Curr Neurobiol. 2010 Mar; 1(1):70-76. PMID: 24052688.
      View in: PubMed
    78. Pessah IN, Cherednichenko G, Lein PJ. Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacol Ther. 2010 Feb; 125(2):260-85. PMID: 19931307; PMCID: PMC2823855.
    79. Halladay AK, Amaral D, Aschner M, Bolivar VJ, Bowman A, DiCicco-Bloom E, Hyman SL, Keller F, Lein P, Pessah I, Restifo L, Threadgill DW. Animal models of autism spectrum disorders: information for neurotoxicologists. Neurotoxicology. 2009 Sep; 30(5):811-21. PMID: 19596370; PMCID: PMC3014989.
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    81. Andres DA, Shi GX, Bruun D, Barnhart C, Lein PJ. Rit signaling contributes to interferon-gamma-induced dendritic retraction via p38 mitogen-activated protein kinase activation. J Neurochem. 2008 Dec; 107(5):1436-47. PMID: 18957053; PMCID: PMC2857931.
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    84. Yang D, Howard A, Bruun D, Ajua-Alemanj M, Pickart C, Lein PJ. Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Toxicol Appl Pharmacol. 2008 Apr 01; 228(1):32-41. PMID: 18076960; PMCID: PMC2408880.
    85. Lein P, Locke P, Goldberg A. Meeting report: alternatives for developmental neurotoxicity testing. Environ Health Perspect. 2007 May; 115(5):764-8. PMID: 17520065; PMCID: PMC1867989.
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    88. Lein PJ, Fryer AD. Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicol Sci. 2005 Jan; 83(1):166-76. PMID: 15470232.
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    89. Fryer AD, Lein PJ, Howard AS, Yost BL, Beckles RA, Jett DA. Mechanisms of organophosphate insecticide-induced airway hyperreactivity. Am J Physiol Lung Cell Mol Physiol. 2004 May; 286(5):L963-9. PMID: 14704222.
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    90. Howard AS, Fitzpatrick R, Pessah I, Kostyniak P, Lein PJ. Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor. Toxicol Appl Pharmacol. 2003 Jul 01; 190(1):72-86. PMID: 12831785.
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    91. Schuh RA, Lein PJ, Beckles RA, Jett DA. Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons. Toxicol Appl Pharmacol. 2002 Jul 15; 182(2):176-85. PMID: 12140181.
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    92. Roth JA, Horbinski C, Higgins D, Lein P, Garrick MD. Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. Neurotoxicology. 2002 Jul; 23(2):147-57. PMID: 12224755.
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