Gene G Gurkoff

Title(s)Associate Professor, Neurological Surgery
SchoolSchool of Medicine
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    PRECISE-TBI: PRE-Clinical Interagency reSearch resourcE-TBI
    VA/BLRD I50BX005878Oct 1, 2021 - Sep 30, 2026
    Role: Co-Director of the Field TBI Core
    Description: The major goal of this program award is to start an Interagency Resource Center Supporting Preclinical TBI Research. The program is made up of six cores including: Administrative, Preclinical Models, Common Data Elements, Informatics, Blast and Field TBI.
    Restoring functional connectivity following TBI
    NIH/NINDS R01NS084026Feb 15, 2014 - Jan 31, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Rehabilitation Potential of Neurostimulation for Mild Traumatic Brain Injury in Animal and Human Studies. Brain Sci. 2023 Sep 30; 13(10). McNerney MW, Gurkoff GG, Beard C, Berryhill ME. PMID: 37891771; PMCID: PMC10605899.
      View in: PubMed   Mentions:
    2. Novel image analysis tool for rapid screening of cell morphology in preclinical animal models of disease. Heliyon. 2023 Feb; 9(2):e13449. Guignet M, Schmuck M, Harvey DJ, Nguyen D, Bruun D, Echeverri A, Gurkoff G, Lein PJ. PMID: 36873154; PMCID: PMC9975095.
      View in: PubMed   Mentions: 1  
    3. Identification of Demographic and Clinical Prognostic Factors in Traumatic Intraventricular Hemorrhage. Neurocrit Care. 2023 02; 38(1):149-157. Scurfield AK, Wilson MD, Gurkoff G, Martin R, Shahlaie K. PMID: 36050537; PMCID: PMC9957945.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Moderate and severe TBI in children and adolescents: The effects of age, sex, and injury severity on patient outcome 6 months after injury. Front Neurol. 2022; 13:741717. Kennedy L, Nuno M, Gurkoff GG, Nosova K, Zwienenberg M. PMID: 35989939; PMCID: PMC9382186.
      View in: PubMed   Mentions: 3  
    5. Sustained ICP Elevation Is a Driver of Spatial Memory Deficits After Intraventricular Hemorrhage and Leads to Activation of Distinct Microglial Signaling Pathways. Transl Stroke Res. 2023 08; 14(4):572-588. Puglisi CH, Ander BP, Peterson C, Keiter JA, Hull H, Hawk CW, Kalistratova VS, Izadi A, Gurkoff GG, Sharp FR, Waldau B. PMID: 35821378; PMCID: PMC9834439.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. Combined Inhibition of Fyn and c-Src Protects Hippocampal Neurons and Improves Spatial Memory via ROCK after Traumatic Brain Injury. J Neurotrauma. 2022 04; 39(7-8):520-529. Ye Z, Izadi A, Gurkoff GG, Rickerl K, Sharp FR, Ander BP, Bauer SZ, Lui A, Lyeth BG, Liu D. PMID: 35109711; PMCID: PMC8978569.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    7. Transcriptional Pathology Evolves over Time in Rat Hippocampus after Lateral Fluid Percussion Traumatic Brain Injury. Neurotrauma Rep. 2021; 2(1):512-525. Catta-Preta R, Zdilar I, Jenner B, Doisy ET, Tercovich K, Nord AS, Gurkoff GG. PMID: 34909768; PMCID: PMC8667199.
      View in: PubMed   Mentions: 2  
    8. Sex-specific acute and chronic neurotoxicity of acute diisopropylfluorophosphate (DFP)-intoxication in juvenile Sprague-Dawley rats. Curr Res Toxicol. 2021; 2:341-356. González EA, Calsbeek JJ, Tsai YH, Tang MY, Andrew P, Vu J, Berg EL, Saito NH, Harvey DJ, Supasai S, Gurkoff GG, Silverman JL, Lein PJ. PMID: 34622217; PMCID: PMC8484742.
      View in: PubMed   Mentions: 6  
    9. Early Intervention via Stimulation of the Medial Septal Nucleus Improves Cognition and Alters Markers of Epileptogenesis in Pilocarpine-Induced Epilepsy. Front Neurol. 2021; 12:708957. Izadi A, Schedlbauer A, Ondek K, Disse G, Ekstrom AD, Cowen SL, Shahlaie K, Gurkoff GG. PMID: 34557145; PMCID: PMC8452867.
      View in: PubMed   Mentions: 2  
    10. Aneurysmal subarachnoid hemorrhage survivors show long-term deficits in spatial reference memory in a pilot study of a virtual water maze paradigm. Clin Neurol Neurosurg. 2021 08; 207:106788. Sanchez B, Delemos CD, Sandhu KS, Peterson C, Cord BJ, Gurkoff GG, Waldau B. PMID: 34230004.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Recovery of Theta Frequency Oscillations in Rats Following Lateral Fluid Percussion Corresponds With a Mild Cognitive Phenotype. Front Neurol. 2020; 11:600171. Ondek K, Pevzner A, Tercovich K, Schedlbauer AM, Izadi A, Ekstrom AD, Cowen SL, Shahlaie K, Gurkoff GG. PMID: 33343499; PMCID: PMC7746872.
      View in: PubMed   Mentions: 5  
    12. An implantable helmet for studying repeat TBI. MethodsX. 2020; 7:101142. Ondek K, Lucero S, Zwienenberg M, Gurkoff G. PMID: 33318954; PMCID: PMC7726661.
      View in: PubMed   Mentions: 1  
    13. Mechanical injury and blood are drivers of spatial memory deficits after rapid intraventricular hemorrhage. Neurobiol Dis. 2020 11; 145:105084. Kamal K, Keiter JA, Binyamin TR, de la Cruz Dapula JN, Vergara AR, Hawk CW, Izadi A, Lyeth B, Gurkoff GG, Sharp FR, Waldau B. PMID: 32941979; PMCID: PMC8478407.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    14. A new model of repeat mTBI in adolescent rats. Exp Neurol. 2020 09; 331:113360. Ondek K, Brevnova O, Jimenez-Ornelas C, Vergara A, Zwienenberg M, Gurkoff G. PMID: 32442552.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    15. From adagio to allegretto: The changing tempo of theta frequencies in epilepsy and its relation to interneuron function. Neurobiol Dis. 2019 09; 129:169-181. Moxon KA, Shahlaie K, Girgis F, Saez I, Kennedy J, Gurkoff GG. PMID: 30798003.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    16. Medial septal stimulation increases seizure threshold and improves cognition in epileptic rats. Brain Stimul. 2019 May - Jun; 12(3):735-742. Izadi A, Pevzner A, Lee DJ, Ekstrom AD, Shahlaie K, Gurkoff GG. PMID: 30733144.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    17. Clinically indicated electrical stimulation strategies to treat patients with medically refractory epilepsy. Epilepsia Open. 2018 Dec; 3(Suppl Suppl 2):198-209. Izadi A, Ondek K, Schedlbauer A, Keselman I, Shahlaie K, Gurkoff G. PMID: 30564779; PMCID: PMC6293066.
      View in: PubMed   Mentions:    Fields:    
    18. A pilot study of subthalamic theta frequency deep brain stimulation for cognitive dysfunction in Parkinson's disease. Brain Stimul. 2018 Mar - Apr; 11(2):456-458. Scangos KW, Carter CS, Gurkoff G, Zhang L, Shahlaie K. PMID: 29203130.
      View in: PubMed   Mentions: 11     Fields:    
    19. Stimulation of the medial septum improves performance in spatial learning following pilocarpine-induced status epilepticus. Epilepsy Res. 2017 02; 130:53-63. Lee DJ, Izadi A, Melnik M, Seidl S, Echeverri A, Shahlaie K, Gurkoff GG. PMID: 28152425.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    20. Making Waves in the Brain: What Are Oscillations, and Why Modulating Them Makes Sense for Brain Injury. Front Syst Neurosci. 2016; 10:30. Pevzner A, Izadi A, Lee DJ, Shahlaie K, Gurkoff GG. PMID: 27092062; PMCID: PMC4823270.
      View in: PubMed   Mentions: 15  
    21. Memory Disruption Following Traumatic Brain Injury. . 2016 Jan 1; 283-320. Berman BR, Lyeth LB, Shahlaie SK, Gurkoff GG. .
      View in: Publisher Site   Mentions:
    22. Impairments in precision, rather than spatial strategy, characterize performance on the virtual Morris Water Maze: A case study. Neuropsychologia. 2016 Jan 08; 80:90-101. Kolarik BS, Shahlaie K, Hassan A, Borders AA, Kaufman KC, Gurkoff G, Yonelinas AP, Ekstrom AD. PMID: 26593960; PMCID: PMC4698252.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    23. Septohippocampal Neuromodulation Improves Cognition after Traumatic Brain Injury. J Neurotrauma. 2015 Nov 15; 32(22):1822-32. Lee DJ, Gurkoff GG, Izadi A, Seidl SE, Echeverri A, Melnik M, Berman RF, Ekstrom AD, Muizelaar JP, Lyeth BG, Shahlaie K. PMID: 26096267; PMCID: PMC4702430.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    24. Intracerebroventricular opiate infusion for refractory head and facial pain. World J Clin Cases. 2014 Aug 16; 2(8):351-6. Lee DJ, Gurkoff GG, Goodarzi A, Muizelaar JP, Boggan JE, Shahlaie K. PMID: 25133146; PMCID: PMC4133425.
      View in: PubMed   Mentions: 2  
    25. Voltage-gated calcium channel antagonists and traumatic brain injury. Pharmaceuticals (Basel). 2013 Jun 26; 6(7):788-812. Gurkoff G, Shahlaie K, Lyeth B, Berman R. PMID: 24276315; PMCID: PMC3816709.
      View in: PubMed   Mentions: 32  
    26. A comparative study of human and rat hippocampal low-frequency oscillations during spatial navigation. Hippocampus. 2013 Aug; 23(8):656-661. Watrous AJ, Lee DJ, Izadi A, Gurkoff GG, Shahlaie K, Ekstrom AD. PMID: 23520039; PMCID: PMC4068262.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimals
    27. NAAG peptidase inhibitor improves motor function and reduces cognitive dysfunction in a model of TBI with secondary hypoxia. Brain Res. 2013 Jun 17; 1515:98-107. Gurkoff GG, Feng JF, Van KC, Izadi A, Ghiasvand R, Shahlaie K, Song M, Lowe DA, Zhou J, Lyeth BG. PMID: 23562458; PMCID: PMC3672358.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    28. Evaluation of metric, topological, and temporal ordering memory tasks after lateral fluid percussion injury. J Neurotrauma. 2013 Feb 15; 30(4):292-300. Gurkoff GG, Gahan JD, Ghiasvand RT, Hunsaker MR, Van K, Feng JF, Shahlaie K, Berman RF, Lyeth BG, Folkerts MM. PMID: 23140483.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    29. Medial septal nucleus theta frequency deep brain stimulation improves spatial working memory after traumatic brain injury. J Neurotrauma. 2013 Jan 15; 30(2):131-9. Lee DJ, Gurkoff GG, Izadi A, Berman RF, Ekstrom AD, Muizelaar JP, Lyeth BG, Shahlaie K. PMID: 23016534.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    30. Neuroprotective effects of SNX-185 in an in vitro model of TBI with a second insult. Restor Neurol Neurosci. 2013; 31(2):141-53. Shahlaie K, Gurkoff GG, Lyeth BG, Muizelaar JP, Berman RF. PMID: 23247061.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    31. NAAG peptidase inhibitor reduces cellular damage in a model of TBI with secondary hypoxia. Brain Res. 2012 Aug 21; 1469:144-52. Feng JF, Gurkoff GG, Van KC, Song M, Lowe DA, Zhou J, Lyeth BG. PMID: 22750589; PMCID: PMC3424068.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    32. In vitro mechanical strain trauma alters neuronal calcium responses: Implications for posttraumatic epilepsy. Epilepsia. 2012 Jun; 53 Suppl 1:53-60. Gurkoff GG, Shahlaie K, Lyeth BG. PMID: 22612809.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    33. Post-traumatic hypoxia exacerbates neuronal cell death in the hippocampus. J Neurotrauma. 2012 Apr 10; 29(6):1167-79. Feng JF, Zhao X, Gurkoff GG, Van KC, Shahlaie K, Lyeth BG. PMID: 22191636; PMCID: PMC3325587.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    34. Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI. Brain Res. 2011 Jun 13; 1395:62-73. Feng JF, Van KC, Gurkoff GG, Kopriva C, Olszewski RT, Song M, Sun S, Xu M, Neale JH, Yuen PW, Lowe DA, Zhou J, Lyeth BG. PMID: 21565332; PMCID: PMC3105192.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    35. Pharmacological enhancement of glutamate transport reduces excitotoxicity in vitro. Restor Neurol Neurosci. 2011; 29(5):331-46. Beller JA, Gurkoff GG, Berman RF, Lyeth BG. PMID: 21846950.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    36. Neuroprotective effects of selective N-type VGCC blockade on stretch-injury-induced calcium dynamics in cortical neurons. J Neurotrauma. 2010 Jan; 27(1):175-87. Shahlaie K, Lyeth BG, Gurkoff GG, Muizelaar JP, Berman RF. PMID: 19772476; PMCID: PMC2824229.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    37. Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat. Neuroscience. 2009 Dec 01; 164(2):862-76. Gurkoff GG, Giza CC, Shin D, Auvin S, Sankar R, Hovda DA. PMID: 19695311; PMCID: PMC2762013.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    38. HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats. Brain Res. 2008 Aug 21; 1226:181-91. Zhang B, West EJ, Van KC, Gurkoff GG, Zhou J, Zhang XM, Kozikowski AP, Lyeth BG. PMID: 18582446; PMCID: PMC2652585.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    39. Essential protective roles of reactive astrocytes in traumatic brain injury. Brain. 2006 Oct; 129(Pt 10):2761-72. Myer DJ, Gurkoff GG, Lee SM, Hovda DA, Sofroniew MV. PMID: 16825202.
      View in: PubMed   Mentions: 295     Fields:    Translation:AnimalsCells
    40. Lateral fluid percussion injury in the developing rat causes an acute, mild behavioral dysfunction in the absence of significant cell death. Brain Res. 2006 Mar 10; 1077(1):24-36. Gurkoff GG, Giza CC, Hovda DA. PMID: 16490184.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
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