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Frank R Sharp

TitlePROF IN RES-HCOMP
InstitutionUniversity of California Davis
DepartmentNeurology
AddressMIND Bldg/UCDMC
CA 95817
Phone916-703-0368
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    Collapse Research 
    Collapse Research Activities and Funding
    Whole Genome RNA Sequencing (RNAseq) of Blood from Patients with Lacunar Stroke
    NIH/NINDS R01NS101718Sep 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Whole Transcriptome Studies of Patients with Transient Ischemic Attacks (TIAs)
    NIH/NINDS R01NS097000Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    NRF2 Anti-Oxidant Systems and White Matter Hyperintensities
    NIH/NIA R01AG042292Apr 1, 2013 - Mar 31, 2018
    Role: Principal Investigator
    A Novel Approach to Assessing Cryptogenic Stroke
    NIH/NINDS R01NS079153Sep 1, 2012 - Apr 30, 2017
    Role: Principal Investigator
    Molecular Biology of Stroke in Humans
    NIH/NINDS R01NS075035Aug 1, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Heat Shock Protein Therapeutics for Stroke
    NIH/NINDS R01NS066845Jun 1, 2010 - May 31, 2015
    Role: Principal Investigator
    Gene Expression and Immune Cell Function in Mothers of Children with Autism
    NIH/NICHD R21HD065269Sep 30, 2009 - Aug 31, 2011
    Role: Co-Principal Investigator
    Ischemic Stroke and Intracerebral Hemorrhage Genomic Studies in Humans
    NIH/NINDS R01NS056302Mar 1, 2007 - Feb 28, 2013
    Role: Principal Investigator
    Hemorrhage Induced Brain Injury
    NIH/NINDS R01NS054652Jan 1, 2007 - Dec 31, 2012
    Role: Principal Investigator
    Neurotoxicity of NMDA Receptor Antagonists
    NIH/NIMH R01MH063079Sep 12, 2002 - Jul 31, 2006
    Role: Principal Investigator
    Neuronal Injury and Blood Genomics
    NIH/NINDS R01NS043252Jun 1, 2002 - May 31, 2007
    Role: Principal Investigator
    Intracerebral Hemorrhage Injury Mechanisms
    NIH/NINDS R01NS042774Dec 15, 2001 - Nov 30, 2007
    Role: Principal Investigator
    BRAIN GENOMIC RESPONSE TO HYPOXIA
    NIH/NIA R21AG019561Mar 15, 2001 - Feb 28, 2004
    Role: Principal Investigator
    ISCHEMIA INDUCED NEUROGENESIS AND PLASTICITY
    NIH/NINDS R01NS038743Jul 15, 1999 - Dec 31, 2003
    Role: Principal Investigator
    STRESS GENES AND HEMORRHAGIC BRAIN INJURY
    NIH/NINDS R01NS038084May 1, 1999 - Feb 28, 2003
    Role: Principal Investigator
    Markers of CNS Injury
    NIH/NINDS R01NS028167Jun 1, 1990 - May 31, 2008
    Role: Principal Investigator
    COREX TRANSPLANTATION
    NIH/NINDS R01NS024666Sep 1, 1987 - Aug 31, 1990
    Role: Principal Investigator
    CNS Injury and Edema Research Center
    NIH/NINDS P50NS014543Jul 1, 1978 - Jul 31, 2012
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shroff N, Ander BP, Zhan X, Stamova B, Liu D, Hull H, Hamade FR, Dykstra-Aiello C, Ng K, Sharp FR, Jickling GC. HDAC9 Polymorphism Alters Blood Gene Expression in Patients with Large Vessel Atherosclerotic Stroke. Transl Stroke Res. 2018 Apr 13. PMID: 29651704.
      View in: PubMed
    2. Ye Z, Ander BP, Sharp FR, Zhan X. Cleaved ß-Actin May Contribute to DNA Fragmentation Following Very Brief Focal Cerebral Ischemia. J Neuropathol Exp Neurol. 2018 Mar 01; 77(3):260-265. PMID: 29408985.
      View in: PubMed
    3. Zhan X, Stamova B, Sharp FR. Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer's Disease Brain: A Review. Front Aging Neurosci. 2018; 10:42. PMID: 29520228.
      View in: PubMed
    4. Stamova B, Ander BP, Jickling G, Hamade F, Durocher M, Zhan X, Liu DZ, Cheng X, Hull H, Yee A, Ng K, Shroff N, Sharp FR. The intracerebral hemorrhage blood transcriptome in humans differs from the ischemic stroke and vascular risk factor control blood transcriptomes. J Cereb Blood Flow Metab. 2018 Jan 01; 271678X18769513. PMID: 29651892.
      View in: PubMed
    5. Sun P, Liu DZ, Jickling GC, Sharp FR, Yin KJ. MicroRNA-based therapeutics in central nervous system injuries. J Cereb Blood Flow Metab. 2018 Jan 01; 271678X18773871. PMID: 29708005.
      View in: PubMed
    6. Swor DE, Sharp FR, Jickling GC. Clinical Reasoning: A case of altered mental status, not otherwise specified. Neurology. 2017 Sep 26; 89(13):e154-e158. PMID: 28947587.
      View in: PubMed
    7. Jauch EC, Barreto AD, Broderick JP, Char DM, Cucchiara BL, Devlin TG, Haddock AJ, Hicks WJ, Hiestand BC, Jickling GC, June J, Liebeskind DS, Lowenkopf TJ, Miller JB, O'Neill J, Schoonover TL, Sharp FR, Peacock WF. Biomarkers of Acute Stroke Etiology (BASE) Study Methodology. Transl Stroke Res. 2017 May 05. PMID: 28477280.
      View in: PubMed
    8. Schumann CM, Sharp FR, Ander BP, Stamova B. Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain. Mol Autism. 2017; 8:4. PMID: 28184278.
      View in: PubMed
    9. Dykstra-Aiello C, Jickling GC, Ander BP, Shroff N, Zhan X, Liu D, Hull H, Orantia M, Stamova BS, Sharp FR. Altered Expression of Long Noncoding RNAs in Blood After Ischemic Stroke and Proximity to Putative Stroke Risk Loci. Stroke. 2016 12; 47(12):2896-2903. PMID: 27834745.
      View in: PubMed
    10. Jickling GC, Ander BP, Shroff N, Orantia M, Stamova B, Dykstra-Aiello C, Hull H, Zhan X, Liu D, Sharp FR. Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke. Neurology. 2016 Nov 22; 87(21):2198-2205. PMID: 27784773.
      View in: PubMed
    11. Zhan X, Stamova B, Jin LW, DeCarli C, Phinney B, Sharp FR. Gram-negative bacterial molecules associate with Alzheimer disease pathology. Neurology. 2016 Nov 29; 87(22):2324-2332. PMID: 27784770.
      View in: PubMed
    12. Liu DZ, Waldau B, Ander BP, Zhan X, Stamova B, Jickling GC, Lyeth BG, Sharp FR. Inhibition of Src family kinases improves cognitive function after intraventricular hemorrhage or intraventricular thrombin. J Cereb Blood Flow Metab. 2017 Jul; 37(7):2359-2367. PMID: 27624844.
      View in: PubMed
    13. Liu da Z, Jickling GC, Ander BP, Hull H, Zhan X, Cox C, Shroff N, Dykstra-Aiello C, Stamova B, Sharp FR. Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2016 Aug; 36(8):1374-83. PMID: 26661204; PMCID: PMC4976655.
    14. Liu DZ, Stamova B, Hu S, Ander BP, Jickling GC, Zhan X, Sharp FR, Wong B. MicroRNA and mRNA Expression Changes in Steroid Naïve and Steroid Treated DMD Patients. J Neuromuscul Dis. 2015 Sep 22; 2(4):387-396. PMID: 27858746.
      View in: PubMed
    15. Stamova B, Ander BP, Barger N, Sharp FR, Schumann CM. Specific Regional and Age-Related Small Noncoding RNA Expression Patterns Within Superior Temporal Gyrus of Typical Human Brains Are Less Distinct in Autism Brains. J Child Neurol. 2015 Dec; 30(14):1930-46. PMID: 26350727; PMCID: PMC4647182.
    16. Jickling GC, Liu D, Ander BP, Stamova B, Zhan X, Sharp FR. Targeting neutrophils in ischemic stroke: translational insights from experimental studies. J Cereb Blood Flow Metab. 2015 Jun; 35(6):888-901. PMID: 25806703; PMCID: PMC4640255.
    17. Jickling GC, Sharp FR. Biomarker panels in ischemic stroke. Stroke. 2015 Mar; 46(3):915-20. PMID: 25657186; PMCID: PMC4342265.
    18. Zhan X, Cox C, Ander BP, Liu D, Stamova B, Jin LW, Jickling GC, Sharp FR. Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-ß and AßPP in Adult Rat Brain. J Alzheimers Dis. 2015; 46(2):507-23. PMID: 25790832; PMCID: PMC4878315.
    19. Zhan X, Jickling GC, Ander BP, Stamova B, Liu D, Kao PF, Zelin MA, Jin LW, DeCarli C, Sharp FR. Myelin basic protein associates with AßPP, Aß1-42, and amyloid plaques in cortex of Alzheimer's disease brain. J Alzheimers Dis. 2015; 44(4):1213-29. PMID: 25697841; PMCID: PMC4422390.
    20. Sharp FR, Jickling GC. Modeling immunity and inflammation in stroke: differences between rodents and humans? Stroke. 2014 Sep; 45(9):e179-80. PMID: 25061082.
      View in: PubMed
    21. Stamova B, Jickling GC, Ander BP, Zhan X, Liu D, Turner R, Ho C, Khoury JC, Bushnell C, Pancioli A, Jauch EC, Broderick JP, Sharp FR. Gene expression in peripheral immune cells following cardioembolic stroke is sexually dimorphic. PLoS One. 2014; 9(7):e102550. PMID: 25036109; PMCID: PMC4103830.
    22. Bai Z, Stamova B, Xu H, Ander BP, Wang J, Jickling GC, Zhan X, Liu D, Han G, Jin LW, DeCarli C, Lei H, Sharp FR. Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities. Alzheimer Dis Assoc Disord. 2014 Jul-Sep; 28(3):226-33. PMID: 24731980; PMCID: PMC4139468.
    23. Liu DZ, Sharp FR, Van KC, Ander BP, Ghiasvand R, Zhan X, Stamova B, Jickling GC, Lyeth BG. Inhibition of SRC family kinases protects hippocampal neurons and improves cognitive function after traumatic brain injury. J Neurotrauma. 2014 Jul 15; 31(14):1268-76. PMID: 24428562; PMCID: PMC4108941.
    24. Zhan X, Jickling GC, Ander BP, Liu D, Stamova B, Cox C, Jin LW, DeCarli C, Sharp FR. Myelin injury and degraded myelin vesicles in Alzheimer's disease. Curr Alzheimer Res. 2014 Mar; 11(3):232-8. PMID: 24484278; PMCID: PMC4066812.
    25. Jickling GC, Sharp FR. Improving the translation of animal ischemic stroke studies to humans. Metab Brain Dis. 2015 Apr; 30(2):461-7. PMID: 24526567; PMCID: PMC4186910.
    26. Jickling GC, Liu D, Stamova B, Ander BP, Zhan X, Lu A, Sharp FR. Hemorrhagic transformation after ischemic stroke in animals and humans. J Cereb Blood Flow Metab. 2014 Feb; 34(2):185-99. PMID: 24281743; PMCID: PMC3915212.
    27. Jickling GC, Ander BP, Stamova B, Zhan X, Liu D, Rothstein L, Verro P, Khoury J, Jauch EC, Pancioli AM, Broderick JP, Sharp FR. RNA in blood is altered prior to hemorrhagic transformation in ischemic stroke. Ann Neurol. 2013 Aug; 74(2):232-40. PMID: 23468366; PMCID: PMC3752310.
    28. Stamova BS, Tian Y, Nordahl CW, Shen MD, Rogers S, Amaral DG, Sharp FR. Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders. Mol Autism. 2013 Sep 04; 4(1):30. PMID: 24007566; PMCID: PMC3846739.
    29. Sharp FR, Zhan X, Liu DZ. Heat shock proteins in the brain: role of Hsp70, Hsp 27, and HO-1 (Hsp32) and their therapeutic potential. Transl Stroke Res. 2013 Dec; 4(6):685-92. PMID: 24323422; PMCID: PMC3858824.
    30. Sharp FR, Jickling GC. Whole genome expression of cellular response to stroke. Stroke. 2013 Jun; 44(6 Suppl 1):S23-5. PMID: 23709718.
      View in: PubMed
    31. Apperson ML, Tian Y, Stamova B, Ander BP, Jickling GC, Agius MA, Sharp FR. Genome wide differences of gene expression associated with HLA-DRB1 genotype in multiple sclerosis: a pilot study. J Neuroimmunol. 2013 Apr 15; 257(1-2):90-6. PMID: 23477965.
      View in: PubMed
    32. Tian Y, Stamova B, Ander BP, Jickling GC, Gunther JR, Corbett BA, Bos-Veneman NG, Hoekstra PJ, Schweitzer JB, Sharp FR. Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in Tourette syndrome: a pilot study. BMC Med Genomics. 2012 Oct 30; 5:49. PMID: 23110997.
      View in: PubMed
    33. Gunther J, Tian Y, Stamova B, Lit L, Corbett B, Ander B, Zhan X, Jickling G, Bos-Veneman N, Liu D, Hoekstra P, Sharp F. Catecholamine-related gene expression in blood correlates with tic severity in tourette syndrome. Psychiatry Res. 2012 Dec 30; 200(2-3):593-601. PMID: 22648010.
      View in: PubMed
    34. Jickling GC, Stamova B, Ander BP, Zhan X, Liu D, Sison SM, Verro P, Sharp FR. Prediction of cardioembolic, arterial, and lacunar causes of cryptogenic stroke by gene expression and infarct location. Stroke. 2012 Aug; 43(8):2036-41. PMID: 22627989.
      View in: PubMed
    35. Liu DZ, Sharp FR. Excitatory and Mitogenic Signaling in Cell Death, Blood-brain Barrier Breakdown, and BBB Repair after Intracerebral Hemorrhage. Transl Stroke Res. 2012 Jul; 3(Suppl 1):62-9. PMID: 24323862.
      View in: PubMed
    36. Tian Y, Stamova B, Jickling GC, Xu H, Liu D, Ander BP, Bushnell C, Zhan X, Turner RJ, Davis RR, Verro P, Pevec WC, Hedayati N, Dawson DL, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. Y chromosome gene expression in the blood of male patients with ischemic stroke compared with male controls. Gend Med. 2012 Apr; 9(2):68-75.e3. PMID: 22365286; PMCID: PMC3454519.
    37. Jickling GC, Zhan X, Stamova B, Ander BP, Tian Y, Liu D, Sison SM, Verro P, Johnston SC, Sharp FR. Ischemic transient neurological events identified by immune response to cerebral ischemia. Stroke. 2012 Apr; 43(4):1006-12. PMID: 22308247; PMCID: PMC3327404.
    38. Liu DZ, Ander BP, Tian Y, Stamova B, Jickling GC, Davis RR, Sharp FR. Integrated analysis of mRNA and microRNA expression in mature neurons, neural progenitor cells and neuroblastoma cells. Gene. 2012 Mar 10; 495(2):120-7. PMID: 22244746.
      View in: PubMed
    39. Tian Y, Stamova B, Jickling GC, Liu D, Ander BP, Bushnell C, Zhan X, Davis RR, Verro P, Pevec WC, Hedayati N, Dawson DL, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. Effects of gender on gene expression in the blood of ischemic stroke patients. J Cereb Blood Flow Metab. 2012 May; 32(5):780-91. PMID: 22167233; PMCID: PMC3345909.
    40. Weinsheimer SM, Xu H, Achrol AS, Stamova B, McCulloch CE, Pawlikowska L, Tian Y, Ko NU, Lawton MT, Steinberg GK, Chang SD, Jickling G, Ander BP, Kim H, Sharp FR, Young WL. Gene expression profiling of blood in brain arteriovenous malformation patients. Transl Stroke Res. 2011 Dec 01; 2(4):575-87. PMID: 22184505; PMCID: PMC3241209.
    41. Stamova B, Tian Y, Jickling G, Bushnell C, Zhan X, Liu D, Ander BP, Verro P, Patel V, Pevec WC, Hedayati N, Dawson DL, Jauch EC, Pancioli A, Broderick JP, Sharp FR. The X-chromosome has a different pattern of gene expression in women compared with men with ischemic stroke. Stroke. 2012 Feb; 43(2):326-34. PMID: 22052522; PMCID: PMC3938328.
    42. Jickling GC, Stamova B, Ander BP, Zhan X, Tian Y, Liu D, Xu H, Johnston SC, Verro P, Sharp FR. Profiles of lacunar and nonlacunar stroke. Ann Neurol. 2011 Sep; 70(3):477-85. PMID: 21796664.
      View in: PubMed
    43. Jickling GC, Sharp FR. Blood biomarkers of ischemic stroke. Neurotherapeutics. 2011 Jul; 8(3):349-60. PMID: 21671123; PMCID: PMC3250275.
    44. Sharp FR, Jickling GC, Stamova B, Tian Y, Zhan X, Ander BP, Cox C, Kuczynski B, Liu D. RNA expression profiles from blood for the diagnosis of stroke and its causes. J Child Neurol. 2011 Sep; 26(9):1131-6. PMID: 21636778; PMCID: PMC3674558.
    45. Turner RJ, Bushnell CD, Register TC, Sharp FR. Gender-dependent correlations of carotid intima-media thickness with gene expression in blood. Transl Stroke Res. 2011 Jun; 2(2):171-8. PMID: 22287995; PMCID: PMC3266847.
    46. Sharp FR, Jickling GC, Stamova B, Tian Y, Zhan X, Liu D, Kuczynski B, Cox CD, Ander BP. Molecular markers and mechanisms of stroke: RNA studies of blood in animals and humans. J Cereb Blood Flow Metab. 2011 Jul; 31(7):1513-31. PMID: 21505474; PMCID: PMC3137473.
    47. Zhan X, Kuczynski B, Sharp FR. Post stroke intervention: is the window widening? Neuropharmacology. 2011 May; 60(6):1000-2. PMID: 21315742.
      View in: PubMed
    48. Turner RJ, Jickling GC, Sharp FR. Are Underlying Assumptions of Current Animal Models of Human Stroke Correct: from STAIRs to High Hurdles? Transl Stroke Res. 2011 Jun; 2(2):138-43. PMID: 21654913.
      View in: PubMed
    49. Tian Y, Gunther JR, Liao IH, Liu D, Ander BP, Stamova BS, Lit L, Jickling GC, Xu H, Zhan X, Sharp FR. GABA- and acetylcholine-related gene expression in blood correlate with tic severity and microarray evidence for alternative splicing in Tourette syndrome: a pilot study. Brain Res. 2011 Mar 24; 1381:228-36. PMID: 21241679.
      View in: PubMed
    50. Liu DZ, Sharp FR. The dual role of SRC kinases in intracerebral hemorrhage. Acta Neurochir Suppl. 2011; 111:77-81. PMID: 21725735.
      View in: PubMed
    51. Tian Y, Apperson ML, Ander BP, Liu D, Stomova BS, Jickling GC, Enriquez R, Agius MA, Sharp FR. Differences in exon expression and alternatively spliced genes in blood of multiple sclerosis compared to healthy control subjects. J Neuroimmunol. 2011 Jan; 230(1-2):124-9. PMID: 20920832.
      View in: PubMed
    52. Tian Y, Liao IH, Zhan X, Gunther JR, Ander BP, Liu D, Lit L, Jickling GC, Corbett BA, Bos-Veneman NG, Hoekstra PJ, Sharp FR. Exon expression and alternatively spliced genes in Tourette Syndrome. Am J Med Genet B Neuropsychiatr Genet. 2011 Jan; 156B(1):72-8. PMID: 21184586; PMCID: PMC3070201.
    53. Jickling GC, Xu H, Stamova B, Ander BP, Zhan X, Tian Y, Liu D, Turner RJ, Mesias M, Verro P, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. Signatures of cardioembolic and large-vessel ischemic stroke. Ann Neurol. 2010 Nov; 68(5):681-92. PMID: 21031583.
      View in: PubMed
    54. Xu H, Stamova B, Jickling G, Tian Y, Zhan X, Ander BP, Liu D, Turner R, Rosand J, Goldstein LB, Furie KL, Verro P, Johnston SC, Sharp FR, Decarli CS. Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain. Stroke. 2010 Dec; 41(12):2744-9. PMID: 20966416.
      View in: PubMed
    55. Sharp FR. Where do omics and markers go next? Transl Stroke Res. 2010 Dec; 1(4):231-2. PMID: 21170137.
      View in: PubMed
    56. Stamova B, Xu H, Jickling G, Bushnell C, Tian Y, Ander BP, Zhan X, Liu D, Turner R, Adamczyk P, Khoury JC, Pancioli A, Jauch E, Broderick JP, Sharp FR. Gene expression profiling of blood for the prediction of ischemic stroke. Stroke. 2010 Oct; 41(10):2171-7. PMID: 20798371; PMCID: PMC2987675.
    57. Liao IH, Sharp FR. Tourette syndrome: gene expression as a tool to discover drug targets. Neurotherapeutics. 2010 Jul; 7(3):302-6. PMID: 20643383.
      View in: PubMed
    58. Jickling GC, Zhan X, Ander BP, Turner RJ, Stamova B, Xu H, Tian Y, Liu D, Davis RR, Lapchak PA, Sharp FR. Genome response to tissue plasminogen activator in experimental ischemic stroke. BMC Genomics. 2010 Apr 21; 11:254. PMID: 20406488; PMCID: PMC2875237.
    59. Liu DZ, Ander BP, Xu H, Shen Y, Kaur P, Deng W, Sharp FR. Blood-brain barrier breakdown and repair by Src after thrombin-induced injury. Ann Neurol. 2010 Apr; 67(4):526-33. PMID: 20437588; PMCID: PMC2919346.
    60. Zhan X, Ander BP, Liao IH, Hansen JE, Kim C, Clements D, Weisbart RH, Nishimura RN, Sharp FR. Recombinant Fv-Hsp70 protein mediates neuroprotection after focal cerebral ischemia in rats. Stroke. 2010 Mar; 41(3):538-43. PMID: 20075343; PMCID: PMC2957177.
    61. Liu DZ, Ander BP, Sharp FR. Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of central nervous system diseases. Neurobiol Dis. 2010 Mar; 37(3):549-57. PMID: 19944161; PMCID: PMC2823995.
    62. Stamova B, Green PG, Tian Y, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Teng J, Gregg JP, Ashwood P, Van de Water J, Sharp FR. Correlations between gene expression and mercury levels in blood of boys with and without autism. Neurotox Res. 2011 Jan; 19(1):31-48. PMID: 19937285.
      View in: PubMed
    63. Tian Y, Green PG, Stamova B, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Gregg JP, Ashwood P, Jickling G, Van de Water J, Sharp FR. Correlations of gene expression with blood lead levels in children with autism compared to typically developing controls. Neurotox Res. 2011 Jan; 19(1):1-13. PMID: 19921347; PMCID: PMC3006638.
    64. Liu DZ, Ander BP, Sharp FR. WITHDRAWN: Cell cycle Inhibition as a Strategy for Treatment of Central Nervous System Diseases. Recent Pat Nanotechnol. 2009 Nov 01. PMID: 19534699.
      View in: PubMed
    65. Zhan X, Ander BP, Jickling G, Turner R, Stamova B, Xu H, Liu D, Davis RR, Sharp FR. Brief focal cerebral ischemia that simulates transient ischemic attacks in humans regulates gene expression in rat peripheral blood. J Cereb Blood Flow Metab. 2010 Jan; 30(1):110-8. PMID: 19738631; PMCID: PMC2949112.
    66. Liu DZ, Tian Y, Ander BP, Xu H, Stamova BS, Zhan X, Turner RJ, Jickling G, Sharp FR. Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab. 2010 Jan; 30(1):92-101. PMID: 19724284; PMCID: PMC2949089.
    67. Stamova BS, Apperson M, Walker WL, Tian Y, Xu H, Adamczy P, Zhan X, Liu DZ, Ander BP, Liao IH, Gregg JP, Turner RJ, Jickling G, Lit L, Sharp FR. Identification and validation of suitable endogenous reference genes for gene expression studies in human peripheral blood. BMC Med Genomics. 2009 Aug 05; 2:49. PMID: 19656400; PMCID: PMC2736983.
    68. Hendren RL, Bertoglio K, Ashwood P, Sharp F. Mechanistic biomarkers for autism treatment. Med Hypotheses. 2009 Dec; 73(6):950-4. PMID: 19619951.
      View in: PubMed
    69. Wong B, Gilbert DL, Walker WL, Liao IH, Lit L, Stamova B, Jickling G, Apperson M, Sharp FR. Gene expression in blood of subjects with Duchenne muscular dystrophy. Neurogenetics. 2009 Apr; 10(2):117-25. PMID: 19067001.
      View in: PubMed
    70. Walker WL, Liao IH, Gilbert DL, Wong B, Pollard KS, McCulloch CE, Lit L, Sharp FR. Empirical Bayes accomodation of batch-effects in microarray data using identical replicate reference samples: application to RNA expression profiling of blood from Duchenne muscular dystrophy patients. BMC Genomics. 2008 Oct 20; 9:494. PMID: 18937867; PMCID: PMC2576259.
    71. Enstrom AM, Lit L, Onore CE, Gregg JP, Hansen RL, Pessah IN, Hertz-Picciotto I, Van de Water JA, Sharp FR, Ashwood P. Altered gene expression and function of peripheral blood natural killer cells in children with autism. Brain Behav Immun. 2009 Jan; 23(1):124-33. PMID: 18762240; PMCID: PMC2636576.
    72. Zhan X, Kim C, Sharp FR. Very brief focal ischemia simulating transient ischemic attacks (TIAs) can injure brain and induce Hsp70 protein. Brain Res. 2008 Oct 09; 1234:183-97. PMID: 18708034; PMCID: PMC2670998.
    73. Xu H, Tang Y, Liu DZ, Ran R, Ander BP, Apperson M, Liu XS, Khoury JC, Gregg JP, Pancioli A, Jauch EC, Wagner KR, Verro P, Broderick JP, Sharp FR. Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic stroke. J Cereb Blood Flow Metab. 2008 Jul; 28(7):1320-8. PMID: 18382470.
      View in: PubMed
    74. Liu DZ, Cheng XY, Ander BP, Xu H, Davis RR, Gregg JP, Sharp FR. Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons. Neurobiol Dis. 2008 May; 30(2):201-11. PMID: 18343677; PMCID: PMC2413433.
    75. Gregg JP, Lit L, Baron CA, Hertz-Picciotto I, Walker W, Davis RA, Croen LA, Ozonoff S, Hansen R, Pessah IN, Sharp FR. Gene expression changes in children with autism. Genomics. 2008 Jan; 91(1):22-9. PMID: 18006270.
      View in: PubMed
    76. Lit L, Gilbert DL, Walker W, Sharp FR. A subgroup of Tourette's patients overexpress specific natural killer cell genes in blood: a preliminary report. Am J Med Genet B Neuropsychiatr Genet. 2007 Oct 05; 144B(7):958-63. PMID: 17503477.
      View in: PubMed
    77. Ran R, Pan R, Lu A, Xu H, Davis RR, Sharp FR. A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis. Mol Cell Neurosci. 2007 Nov; 36(3):392-407. PMID: 17888676.
      View in: PubMed
    78. Sharp FR, Hendren RL. Psychosis: atypical limbic epilepsy versus limbic hyperexcitability with onset at puberty? Epilepsy Behav. 2007 Jun; 10(4):515-20. PMID: 17416210; PMCID: PMC2680611.
    79. Ardizzone TD, Zhan X, Ander BP, Sharp FR. SRC kinase inhibition improves acute outcomes after experimental intracerebral hemorrhage. Stroke. 2007 May; 38(5):1621-5. PMID: 17395859.
      View in: PubMed
    80. Sharp FR, Xu H, Lit L, Walker W, Pinter J, Apperson M, Verro P. Genomic profiles of stroke in blood. Stroke. 2007 Feb; 38(2 Suppl):691-3. PMID: 17261717.
      View in: PubMed
    81. Sharp FR, Xu H, Lit L, Walker W, Apperson M, Gilbert DL, Glauser TA, Wong B, Hershey A, Liu DZ, Pinter J, Zhan X, Liu X, Ran R. The future of genomic profiling of neurological diseases using blood. Arch Neurol. 2006 Nov; 63(11):1529-36. PMID: 17101821.
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    82. Sharp FR, Lit L, Xu H, Apperson M, Walker W, Wong B, Gilbert DL, Hershey A, Glauser TA. Genomics of brain and blood: progress and pitfalls. Epilepsia. 2006 Oct; 47(10):1603-7. PMID: 17054680.
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    83. Vexler ZS, Sharp FR, Feuerstein GZ, Ashwal S, Thoresen M, Yager JY, Ferriero DM. Translational stroke research in the developing brain. Pediatr Neurol. 2006 Jun; 34(6):459-63. PMID: 16765824.
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    84. Lu A, Tang Y, Ran R, Ardizzone TL, Wagner KR, Sharp FR. Brain genomics of intracerebral hemorrhage. J Cereb Blood Flow Metab. 2006 Feb; 26(2):230-52. PMID: 16034371.
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    85. Tang Y, Xu H, Du X, Lit L, Walker W, Lu A, Ran R, Gregg JP, Reilly M, Pancioli A, Khoury JC, Sauerbeck LR, Carrozzella JA, Spilker J, Clark J, Wagner KR, Jauch EC, Chang DJ, Verro P, Broderick JP, Sharp FR. Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. J Cereb Blood Flow Metab. 2006 Aug; 26(8):1089-102. PMID: 16395289.
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    86. Dickerson J, Sharp FR. Atypical antipsychotics and a Src kinase inhibitor (PP1) prevent cortical injury produced by the psychomimetic, noncompetitive NMDA receptor antagonist MK-801. Neuropsychopharmacology. 2006 Jul; 31(7):1420-30. PMID: 16123741.
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    87. Ran R, Xu H, Lu A, Bernaudin M, Sharp FR. Hypoxia preconditioning in the brain. Dev Neurosci. 2005 Mar-Aug; 27(2-4):87-92. PMID: 16046841.
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    88. Tang Y, Schapiro MB, Franz DN, Patterson BJ, Hickey FJ, Schorry EK, Hopkin RJ, Wylie M, Narayan T, Glauser TA, Gilbert DL, Hershey AD, Sharp FR. Blood expression profiles for tuberous sclerosis complex 2, neurofibromatosis type 1, and Down's syndrome. Ann Neurol. 2004 Dec; 56(6):808-14. PMID: 15562430.
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    89. Glass TF, Reeves B, Sharp FR. The impact of excitotoxic blockade on the evolution of injury following combined mechanical and hypoxic insults in primary rat neuronal culture. Neurobiol Dis. 2004 Dec; 17(3):378-84. PMID: 15571974.
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    90. Carter K, Dickerson J, Schoepp DD, Reilly M, Herring N, Williams J, Sallee FR, Sharp JW, Sharp FR. The mGlu2/3 receptor agonist LY379268 injected into cortex or thalamus decreases neuronal injury in retrosplenial cortex produced by NMDA receptor antagonist MK-801: possible implications for psychosis. Neuropharmacology. 2004 Dec; 47(8):1135-45. PMID: 15567423.
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    91. Weinstein PR, Hong S, Sharp FR. Molecular identification of the ischemic penumbra. Stroke. 2004 Nov; 35(11 Suppl 1):2666-70. PMID: 15486332.
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    92. Ardizzone TD, Lu A, Wagner KR, Tang Y, Ran R, Sharp FR. Glutamate receptor blockade attenuates glucose hypermetabolism in perihematomal brain after experimental intracerebral hemorrhage in rat. Stroke. 2004 Nov; 35(11):2587-91. PMID: 15375303.
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    93. Yamauchi T, Lin Y, Sharp FR, Noble-Haeusslein LJ. Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord. J Neurotrauma. 2004 Aug; 21(8):1017-30. PMID: 15319001.
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