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Frank R Sharp

Title(s)Professor, Neurology
SchoolUniversity of California, Davis
Phone916-703-0368
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    Collapse Research 
    Collapse Research Activities and Funding
    Genomics of Intracerebral Hemorrhage and its Causes
    NIH/NINDS R01NS106950Apr 1, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Whole Genome RNA Sequencing (RNAseq) of Blood from Patients with Lacunar Stroke
    NIH/NINDS R01NS101718Sep 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Whole Transcriptome Studies of Patients with Transient Ischemic Attacks (TIAs)
    NIH/NINDS R01NS097000Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    NRF2 Anti-Oxidant Systems and White Matter Hyperintensities
    NIH/NIA R01AG042292Apr 1, 2013 - Mar 31, 2018
    Role: Principal Investigator
    A Novel Approach to Assessing Cryptogenic Stroke
    NIH/NINDS R01NS079153Sep 1, 2012 - Apr 30, 2017
    Role: Principal Investigator
    Molecular Biology of Stroke in Humans
    NIH/NINDS R01NS075035Aug 1, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Heat Shock Protein Therapeutics for Stroke
    NIH/NINDS R01NS066845Jun 1, 2010 - May 31, 2015
    Role: Principal Investigator
    Gene Expression and Immune Cell Function in Mothers of Children with Autism
    NIH/NICHD R21HD065269Sep 30, 2009 - Aug 31, 2011
    Role: Co-Principal Investigator
    Ischemic Stroke and Intracerebral Hemorrhage Genomic Studies in Humans
    NIH/NINDS R01NS056302Mar 1, 2007 - Feb 28, 2013
    Role: Principal Investigator
    Hemorrhage Induced Brain Injury
    NIH/NINDS R01NS054652Jan 1, 2007 - Dec 31, 2012
    Role: Principal Investigator
    Neurotoxicity of NMDA Receptor Antagonists
    NIH/NIMH R01MH063079Sep 12, 2002 - Jul 31, 2006
    Role: Principal Investigator
    Neuronal Injury and Blood Genomics
    NIH/NINDS R01NS043252Jun 1, 2002 - May 31, 2007
    Role: Principal Investigator
    Intracerebral Hemorrhage Injury Mechanisms
    NIH/NINDS R01NS042774Dec 15, 2001 - Nov 30, 2007
    Role: Principal Investigator
    BRAIN GENOMIC RESPONSE TO HYPOXIA
    NIH/NIA R21AG019561Mar 15, 2001 - Feb 28, 2004
    Role: Principal Investigator
    ISCHEMIA INDUCED NEUROGENESIS AND PLASTICITY
    NIH/NINDS R01NS038743Jul 15, 1999 - Dec 31, 2003
    Role: Principal Investigator
    STRESS GENES AND HEMORRHAGIC BRAIN INJURY
    NIH/NINDS R01NS038084May 1, 1999 - Feb 28, 2003
    Role: Principal Investigator
    Markers of CNS Injury
    NIH/NINDS R01NS028167Jun 1, 1990 - May 31, 2008
    Role: Principal Investigator
    COREX TRANSPLANTATION
    NIH/NINDS R01NS024666Sep 1, 1987 - Aug 31, 1990
    Role: Principal Investigator
    CNS Injury and Edema Research Center
    NIH/NINDS P50NS014543Jul 1, 1978 - Jul 31, 2012
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Xu H, Stamova B, Ander BP, Waldau B, Jickling GC, Sharp FR, Ko NU. mRNA Expression Profiles from Whole Blood Associated with Vasospasm in Patients with Subarachnoid Hemorrhage. Neurocrit Care. 2019 Oct 08. PMID: 31595394.
      View in: PubMed
    2. Navi BB, Mathias R, Sherman CP, Wolfe J, Kamel H, Tagawa ST, Saxena A, Ocean AJ, Iadecola C, DeAngelis LM, Elkind MSV, Hull H, Jickling GC, Sharp FR, Ander BP, Stamova B. Cancer-Related Ischemic Stroke Has a Distinct Blood mRNA Expression Profile. Stroke. 2019 Sep 12; STROKEAHA119026143. PMID: 31510897.
      View in: PubMed
    3. Cheng X, Ferino E, Hull H, Jickling GC, Ander BP, Stamova B, Sharp FR. Smoking affects gene expression in blood of patients with ischemic stroke. Ann Clin Transl Neurol. 2019 Sep; 6(9):1748-1756. PMID: 31436916.
      View in: PubMed
    4. Cheng X, Ander BP, Jickling GC, Zhan X, Hull H, Sharp FR, Stamova B. MicroRNA and their target mRNAs change expression in whole blood of patients after intracerebral hemorrhage. J Cereb Blood Flow Metab. 2019 Apr 09; 271678X19839501. PMID: 30966854.
      View in: PubMed
    5. Durocher M, Ander BP, Jickling G, Hamade F, Hull H, Knepp B, Liu DZ, Zhan X, Tran A, Cheng X, Ng K, Yee A, Sharp FR, Stamova B. Inflammatory, regulatory, and autophagy co-expression modules and hub genes underlie the peripheral immune response to human intracerebral hemorrhage. J Neuroinflammation. 2019 Mar 05; 16(1):56. PMID: 30836997.
      View in: PubMed
    6. Lv B, Cheng X, Sharp FR, Ander BP, Liu DZ. MicroRNA-122 Mimic Improves Stroke Outcomes and Indirectly Inhibits NOS2 After Middle Cerebral Artery Occlusion in Rats. Front Neurosci. 2018; 12:767. PMID: 30405345.
      View in: PubMed
    7. Sun P, Liu DZ, Jickling GC, Sharp FR, Yin KJ. MicroRNA-based therapeutics in central nervous system injuries. J Cereb Blood Flow Metab. 2018 07; 38(7):1125-1148. PMID: 29708005.
      View in: PubMed
    8. Stamova B, Ander BP, Jickling G, Hamade F, Durocher M, Zhan X, Liu DZ, Cheng X, Hull H, Yee A, Ng K, Shroff N, Sharp FR. The intracerebral hemorrhage blood transcriptome in humans differs from the ischemic stroke and vascular risk factor control blood transcriptomes. J Cereb Blood Flow Metab. 2019 Sep; 39(9):1818-1835. PMID: 29651892.
      View in: PubMed
    9. Shroff N, Ander BP, Zhan X, Stamova B, Liu D, Hull H, Hamade FR, Dykstra-Aiello C, Ng K, Sharp FR, Jickling GC. HDAC9 Polymorphism Alters Blood Gene Expression in Patients with Large Vessel Atherosclerotic Stroke. Transl Stroke Res. 2019 02; 10(1):19-25. PMID: 29651704.
      View in: PubMed
    10. Ye Z, Ander BP, Sharp FR, Zhan X. Cleaved ß-Actin May Contribute to DNA Fragmentation Following Very Brief Focal Cerebral Ischemia. J Neuropathol Exp Neurol. 2018 03 01; 77(3):260-265. PMID: 29408985.
      View in: PubMed
    11. Zhan X, Stamova B, Sharp FR. Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer's Disease Brain: A Review. Front Aging Neurosci. 2018; 10:42. PMID: 29520228.
      View in: PubMed
    12. Swor DE, Sharp FR, Jickling GC. Clinical Reasoning: A case of altered mental status, not otherwise specified. Neurology. 2017 09 26; 89(13):e154-e158. PMID: 28947587.
      View in: PubMed
    13. Jauch EC, Barreto AD, Broderick JP, Char DM, Cucchiara BL, Devlin TG, Haddock AJ, Hicks WJ, Hiestand BC, Jickling GC, June J, Liebeskind DS, Lowenkopf TJ, Miller JB, O'Neill J, Schoonover TL, Sharp FR, Peacock WF. Biomarkers of Acute Stroke Etiology (BASE) Study Methodology. Transl Stroke Res. 2017 May 05. PMID: 28477280.
      View in: PubMed
    14. Schumann CM, Sharp FR, Ander BP, Stamova B. Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain. Mol Autism. 2017; 8:4. PMID: 28184278.
      View in: PubMed
    15. Tylee DS, Hess JL, Quinn TP, Barve R, Huang H, Zhang-James Y, Chang J, Stamova BS, Sharp FR, Hertz-Picciotto I, Faraone SV, Kong SW, Glatt SJ. Blood transcriptomic comparison of individuals with and without autism spectrum disorder: A combined-samples mega-analysis. Am J Med Genet B Neuropsychiatr Genet. 2017 Apr; 174(3):181-201. PMID: 27862943.
      View in: PubMed
    16. Dykstra-Aiello C, Jickling GC, Ander BP, Shroff N, Zhan X, Liu D, Hull H, Orantia M, Stamova BS, Sharp FR. Altered Expression of Long Noncoding RNAs in Blood After Ischemic Stroke and Proximity to Putative Stroke Risk Loci. Stroke. 2016 12; 47(12):2896-2903. PMID: 27834745.
      View in: PubMed
    17. Jickling GC, Ander BP, Shroff N, Orantia M, Stamova B, Dykstra-Aiello C, Hull H, Zhan X, Liu D, Sharp FR. Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke. Neurology. 2016 Nov 22; 87(21):2198-2205. PMID: 27784773.
      View in: PubMed
    18. Zhan X, Stamova B, Jin LW, DeCarli C, Phinney B, Sharp FR. Gram-negative bacterial molecules associate with Alzheimer disease pathology. Neurology. 2016 Nov 29; 87(22):2324-2332. PMID: 27784770.
      View in: PubMed
    19. Turner RJ, Sharp FR. Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke. Front Cell Neurosci. 2016; 10:56. PMID: 26973468.
      View in: PubMed
    20. Liu DZ, Waldau B, Ander BP, Zhan X, Stamova B, Jickling GC, Lyeth BG, Sharp FR. Inhibition of Src family kinases improves cognitive function after intraventricular hemorrhage or intraventricular thrombin. J Cereb Blood Flow Metab. 2017 Jul; 37(7):2359-2367. PMID: 27624844.
      View in: PubMed
    21. Liu da Z, Jickling GC, Ander BP, Hull H, Zhan X, Cox C, Shroff N, Dykstra-Aiello C, Stamova B, Sharp FR. Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2016 08; 36(8):1374-83. PMID: 26661204.
      View in: PubMed
    22. Liu DZ, Stamova B, Hu S, Ander BP, Jickling GC, Zhan X, Sharp FR, Wong B. MicroRNA and mRNA Expression Changes in Steroid Naïve and Steroid Treated DMD Patients. J Neuromuscul Dis. 2015 Sep 22; 2(4):387-396. PMID: 27858746.
      View in: PubMed
    23. Stamova B, Ander BP, Barger N, Sharp FR, Schumann CM. Specific Regional and Age-Related Small Noncoding RNA Expression Patterns Within Superior Temporal Gyrus of Typical Human Brains Are Less Distinct in Autism Brains. J Child Neurol. 2015 Dec; 30(14):1930-46. PMID: 26350727.
      View in: PubMed
    24. Ander BP, Barger N, Stamova B, Sharp FR, Schumann CM. Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders. Mol Autism. 2015; 6:37. PMID: 26146533.
      View in: PubMed
    25. Jickling GC, Liu D, Ander BP, Stamova B, Zhan X, Sharp FR. Targeting neutrophils in ischemic stroke: translational insights from experimental studies. J Cereb Blood Flow Metab. 2015 Jun; 35(6):888-901. PMID: 25806703.
      View in: PubMed
    26. Jickling GC, Sharp FR. Biomarker panels in ischemic stroke. Stroke. 2015 Mar; 46(3):915-20. PMID: 25657186.
      View in: PubMed
    27. Zhan X, Jickling GC, Ander BP, Stamova B, Liu D, Kao PF, Zelin MA, Jin LW, DeCarli C, Sharp FR. Myelin basic protein associates with AßPP, Aß1-42, and amyloid plaques in cortex of Alzheimer's disease brain. J Alzheimers Dis. 2015; 44(4):1213-29. PMID: 25697841.
      View in: PubMed
    28. Zhan X, Cox C, Ander BP, Liu D, Stamova B, Jin LW, Jickling GC, Sharp FR. Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-ß and AßPP in Adult Rat Brain. J Alzheimers Dis. 2015; 46(2):507-23. PMID: 25790832.
      View in: PubMed
    29. Sellier C, Hwang VJ, Dandekar R, Durbin-Johnson B, Charlet-Berguerand N, Ander BP, Sharp FR, Angkustsiri K, Simon TJ, Tassone F. Decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 deletion syndrome. PLoS One. 2014; 9(8):e103884. PMID: 25084529.
      View in: PubMed
    30. Sharp FR, Jickling GC. Modeling immunity and inflammation in stroke: differences between rodents and humans? Stroke. 2014 Sep; 45(9):e179-80. PMID: 25061082.
      View in: PubMed
    31. Stamova B, Jickling GC, Ander BP, Zhan X, Liu D, Turner R, Ho C, Khoury JC, Bushnell C, Pancioli A, Jauch EC, Broderick JP, Sharp FR. Gene expression in peripheral immune cells following cardioembolic stroke is sexually dimorphic. PLoS One. 2014; 9(7):e102550. PMID: 25036109.
      View in: PubMed
    32. Bai Z, Stamova B, Xu H, Ander BP, Wang J, Jickling GC, Zhan X, Liu D, Han G, Jin LW, DeCarli C, Lei H, Sharp FR. Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities. Alzheimer Dis Assoc Disord. 2014 Jul-Sep; 28(3):226-33. PMID: 24731980.
      View in: PubMed
    33. Liu DZ, Sharp FR, Van KC, Ander BP, Ghiasvand R, Zhan X, Stamova B, Jickling GC, Lyeth BG. Inhibition of SRC family kinases protects hippocampal neurons and improves cognitive function after traumatic brain injury. J Neurotrauma. 2014 Jul 15; 31(14):1268-76. PMID: 24428562.
      View in: PubMed
    34. Zhan X, Jickling GC, Ander BP, Liu D, Stamova B, Cox C, Jin LW, DeCarli C, Sharp FR. Myelin injury and degraded myelin vesicles in Alzheimer's disease. Curr Alzheimer Res. 2014 Mar; 11(3):232-8. PMID: 24484278.
      View in: PubMed
    35. Jickling GC, Sharp FR. Improving the translation of animal ischemic stroke studies to humans. Metab Brain Dis. 2015 Apr; 30(2):461-7. PMID: 24526567.
      View in: PubMed
    36. Jickling GC, Liu D, Stamova B, Ander BP, Zhan X, Lu A, Sharp FR. Hemorrhagic transformation after ischemic stroke in animals and humans. J Cereb Blood Flow Metab. 2014 Feb; 34(2):185-99. PMID: 24281743.
      View in: PubMed
    37. Weis SN, Toniazzo AP, Ander BP, Zhan X, Careaga M, Ashwood P, Wyse AT, Netto CA, Sharp FR. Autophagy in the brain of neonates following hypoxia-ischemia shows sex- and region-specific effects. Neuroscience. 2014 Jan 03; 256:201-9. PMID: 24184979.
      View in: PubMed
    38. Jickling GC, Ander BP, Stamova B, Zhan X, Liu D, Rothstein L, Verro P, Khoury J, Jauch EC, Pancioli AM, Broderick JP, Sharp FR. RNA in blood is altered prior to hemorrhagic transformation in ischemic stroke. Ann Neurol. 2013 Aug; 74(2):232-40. PMID: 23468366.
      View in: PubMed
    39. Stamova BS, Tian Y, Nordahl CW, Shen MD, Rogers S, Amaral DG, Sharp FR. Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders. Mol Autism. 2013 Sep 04; 4(1):30. PMID: 24007566.
      View in: PubMed
    40. Sharp FR, Zhan X, Liu DZ. Heat shock proteins in the brain: role of Hsp70, Hsp 27, and HO-1 (Hsp32) and their therapeutic potential. Transl Stroke Res. 2013 Dec; 4(6):685-92. PMID: 24323422.
      View in: PubMed
    41. Peng B, Zhu D, Ander BP, Zhang X, Xue F, Sharp FR, Yang X. An integrative framework for Bayesian variable selection with informative priors for identifying genes and pathways. PLoS One. 2013; 8(7):e67672. PMID: 23844055.
      View in: PubMed
    42. Sharp FR, Jickling GC. Whole genome expression of cellular response to stroke. Stroke. 2013 Jun; 44(6 Suppl 1):S23-5. PMID: 23709718.
      View in: PubMed
    43. Cox C, Sharp FR. RNA-based blood genomics as an investigative tool and prospective biomarker for ischemic stroke. Neurol Res. 2013 Jun; 35(5):457-64. PMID: 23635721.
      View in: PubMed
    44. Apperson ML, Tian Y, Stamova B, Ander BP, Jickling GC, Agius MA, Sharp FR. Genome wide differences of gene expression associated with HLA-DRB1 genotype in multiple sclerosis: a pilot study. J Neuroimmunol. 2013 Apr 15; 257(1-2):90-6. PMID: 23477965.
      View in: PubMed
    45. Paschou P, Fernandez TV, Sharp F, Heiman GA, Hoekstra PJ. Genetic susceptibility and neurotransmitters in Tourette syndrome. Int Rev Neurobiol. 2013; 112:155-77. PMID: 24295621.
      View in: PubMed
    46. Tian Y, Stamova B, Ander BP, Jickling GC, Gunther JR, Corbett BA, Bos-Veneman NG, Hoekstra PJ, Schweitzer JB, Sharp FR. Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in Tourette syndrome: a pilot study. BMC Med Genomics. 2012 Oct 30; 5:49. PMID: 23110997.
      View in: PubMed
    47. Gunther J, Tian Y, Stamova B, Lit L, Corbett B, Ander B, Zhan X, Jickling G, Bos-Veneman N, Liu D, Hoekstra P, Sharp F. Catecholamine-related gene expression in blood correlates with tic severity in tourette syndrome. Psychiatry Res. 2012 Dec 30; 200(2-3):593-601. PMID: 22648010.
      View in: PubMed
    48. Jickling GC, Stamova B, Ander BP, Zhan X, Liu D, Sison SM, Verro P, Sharp FR. Prediction of cardioembolic, arterial, and lacunar causes of cryptogenic stroke by gene expression and infarct location. Stroke. 2012 Aug; 43(8):2036-41. PMID: 22627989.
      View in: PubMed
    49. Liu DZ, Sharp FR. Excitatory and Mitogenic Signaling in Cell Death, Blood-brain Barrier Breakdown, and BBB Repair after Intracerebral Hemorrhage. Transl Stroke Res. 2012 Jul; 3(Suppl 1):62-9. PMID: 24323862.
      View in: PubMed
    50. Tian Y, Stamova B, Jickling GC, Xu H, Liu D, Ander BP, Bushnell C, Zhan X, Turner RJ, Davis RR, Verro P, Pevec WC, Hedayati N, Dawson DL, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. Y chromosome gene expression in the blood of male patients with ischemic stroke compared with male controls. Gend Med. 2012 Apr; 9(2):68-75.e3. PMID: 22365286.
      View in: PubMed
    51. Jickling GC, Zhan X, Stamova B, Ander BP, Tian Y, Liu D, Sison SM, Verro P, Johnston SC, Sharp FR. Ischemic transient neurological events identified by immune response to cerebral ischemia. Stroke. 2012 Apr; 43(4):1006-12. PMID: 22308247.
      View in: PubMed
    52. Liu DZ, Ander BP, Tian Y, Stamova B, Jickling GC, Davis RR, Sharp FR. Integrated analysis of mRNA and microRNA expression in mature neurons, neural progenitor cells and neuroblastoma cells. Gene. 2012 Mar 10; 495(2):120-7. PMID: 22244746.
      View in: PubMed
    53. Tian Y, Stamova B, Jickling GC, Liu D, Ander BP, Bushnell C, Zhan X, Davis RR, Verro P, Pevec WC, Hedayati N, Dawson DL, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. Effects of gender on gene expression in the blood of ischemic stroke patients. J Cereb Blood Flow Metab. 2012 May; 32(5):780-91. PMID: 22167233.
      View in: PubMed
    54. Weinsheimer SM, Xu H, Achrol AS, Stamova B, McCulloch CE, Pawlikowska L, Tian Y, Ko NU, Lawton MT, Steinberg GK, Chang SD, Jickling G, Ander BP, Kim H, Sharp FR, Young WL. Gene expression profiling of blood in brain arteriovenous malformation patients. Transl Stroke Res. 2011 Dec 01; 2(4):575-87. PMID: 22184505.
      View in: PubMed
    55. Stamova B, Tian Y, Jickling G, Bushnell C, Zhan X, Liu D, Ander BP, Verro P, Patel V, Pevec WC, Hedayati N, Dawson DL, Jauch EC, Pancioli A, Broderick JP, Sharp FR. The X-chromosome has a different pattern of gene expression in women compared with men with ischemic stroke. Stroke. 2012 Feb; 43(2):326-34. PMID: 22052522.
      View in: PubMed
    56. Zhan X, Jickling GC, Tian Y, Stamova B, Xu H, Ander BP, Turner RJ, Mesias M, Verro P, Bushnell C, Johnston SC, Sharp FR. Transient ischemic attacks characterized by RNA profiles in blood. Neurology. 2011 Nov 08; 77(19):1718-24. PMID: 21998319.
      View in: PubMed
    57. Xu H, Lu A, Sharp FR. Regional genome transcriptional response of adult mouse brain to hypoxia. BMC Genomics. 2011 Oct 11; 12:499. PMID: 21988864.
      View in: PubMed
    58. Jickling GC, Stamova B, Ander BP, Zhan X, Tian Y, Liu D, Xu H, Johnston SC, Verro P, Sharp FR. Profiles of lacunar and nonlacunar stroke. Ann Neurol. 2011 Sep; 70(3):477-85. PMID: 21796664.
      View in: PubMed
    59. del Zoppo GJ, Sharp FR, Heiss WD, Albers GW. Heterogeneity in the penumbra. J Cereb Blood Flow Metab. 2011 Sep; 31(9):1836-51. PMID: 21731034.
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    60. Jickling GC, Sharp FR. Blood biomarkers of ischemic stroke. Neurotherapeutics. 2011 Jul; 8(3):349-60. PMID: 21671123.
      View in: PubMed
    61. Lit L, Sharp FR, Bertoglio K, Stamova B, Ander BP, Sossong AD, Hendren RL. Gene expression in blood is associated with risperidone response in children with autism spectrum disorders. Pharmacogenomics J. 2012 Oct; 12(5):368-71. PMID: 21647175.
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    62. Sharp FR, Jickling GC, Stamova B, Tian Y, Zhan X, Ander BP, Cox C, Kuczynski B, Liu D. RNA expression profiles from blood for the diagnosis of stroke and its causes. J Child Neurol. 2011 Sep; 26(9):1131-6. PMID: 21636778.
      View in: PubMed
    63. Turner RJ, Bushnell CD, Register TC, Sharp FR. Gender-dependent correlations of carotid intima-media thickness with gene expression in blood. Transl Stroke Res. 2011 Jun; 2(2):171-8. PMID: 22287995.
      View in: PubMed
    64. Sharp FR, Jickling GC, Stamova B, Tian Y, Zhan X, Liu D, Kuczynski B, Cox CD, Ander BP. Molecular markers and mechanisms of stroke: RNA studies of blood in animals and humans. J Cereb Blood Flow Metab. 2011 Jul; 31(7):1513-31. PMID: 21505474.
      View in: PubMed
    65. Neuwelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, Janigro D, Leybaert L, Molnár Z, O'Donnell ME, Povlishock JT, Saunders NR, Sharp F, Stanimirovic D, Watts RJ, Drewes LR. Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci. 2011 Mar; 12(3):169-82. PMID: 21331083.
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    66. Zhan X, Kuczynski B, Sharp FR. Post stroke intervention: is the window widening? Neuropharmacology. 2011 May; 60(6):1000-2. PMID: 21315742.
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    67. Turner RJ, Jickling GC, Sharp FR. Are Underlying Assumptions of Current Animal Models of Human Stroke Correct: from STAIRs to High Hurdles? Transl Stroke Res. 2011 Jun; 2(2):138-43. PMID: 21654913.
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    68. Tian Y, Gunther JR, Liao IH, Liu D, Ander BP, Stamova BS, Lit L, Jickling GC, Xu H, Zhan X, Sharp FR. GABA- and acetylcholine-related gene expression in blood correlate with tic severity and microarray evidence for alternative splicing in Tourette syndrome: a pilot study. Brain Res. 2011 Mar 24; 1381:228-36. PMID: 21241679.
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    69. Liu DZ, Sharp FR. The dual role of SRC kinases in intracerebral hemorrhage. Acta Neurochir Suppl. 2011; 111:77-81. PMID: 21725735.
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    70. Tian Y, Apperson ML, Ander BP, Liu D, Stomova BS, Jickling GC, Enriquez R, Agius MA, Sharp FR. Differences in exon expression and alternatively spliced genes in blood of multiple sclerosis compared to healthy control subjects. J Neuroimmunol. 2011 Jan; 230(1-2):124-9. PMID: 20920832.
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    71. Liao IH, Corbett BA, Gilbert DL, Bunge SA, Sharp FR. Blood gene expression correlated with tic severity in medicated and unmedicated patients with Tourette Syndrome. Pharmacogenomics. 2010 Dec; 11(12):1733-41. PMID: 21142917.
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    72. Tian Y, Liao IH, Zhan X, Gunther JR, Ander BP, Liu D, Lit L, Jickling GC, Corbett BA, Bos-Veneman NG, Hoekstra PJ, Sharp FR. Exon expression and alternatively spliced genes in Tourette Syndrome. Am J Med Genet B Neuropsychiatr Genet. 2011 Jan; 156B(1):72-8. PMID: 21184586.
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    73. Jickling GC, Xu H, Stamova B, Ander BP, Zhan X, Tian Y, Liu D, Turner RJ, Mesias M, Verro P, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. Signatures of cardioembolic and large-vessel ischemic stroke. Ann Neurol. 2010 Nov; 68(5):681-92. PMID: 21031583.
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    74. Xu H, Stamova B, Jickling G, Tian Y, Zhan X, Ander BP, Liu D, Turner R, Rosand J, Goldstein LB, Furie KL, Verro P, Johnston SC, Sharp FR, Decarli CS. Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain. Stroke. 2010 Dec; 41(12):2744-9. PMID: 20966416.
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    75. Sharp FR. Where do omics and markers go next? Transl Stroke Res. 2010 Dec; 1(4):231-2. PMID: 21170137.
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    76. Stamova B, Xu H, Jickling G, Bushnell C, Tian Y, Ander BP, Zhan X, Liu D, Turner R, Adamczyk P, Khoury JC, Pancioli A, Jauch E, Broderick JP, Sharp FR. Gene expression profiling of blood for the prediction of ischemic stroke. Stroke. 2010 Oct; 41(10):2171-7. PMID: 20798371.
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    77. Liao IH, Sharp FR. Tourette syndrome: gene expression as a tool to discover drug targets. Neurotherapeutics. 2010 Jul; 7(3):302-6. PMID: 20643383.
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    78. Jickling GC, Zhan X, Ander BP, Turner RJ, Stamova B, Xu H, Tian Y, Liu D, Davis RR, Lapchak PA, Sharp FR. Genome response to tissue plasminogen activator in experimental ischemic stroke. BMC Genomics. 2010 Apr 21; 11:254. PMID: 20406488.
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    79. Liu DZ, Ander BP, Xu H, Shen Y, Kaur P, Deng W, Sharp FR. Blood-brain barrier breakdown and repair by Src after thrombin-induced injury. Ann Neurol. 2010 Apr; 67(4):526-33. PMID: 20437588.
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    80. Zhan X, Ander BP, Liao IH, Hansen JE, Kim C, Clements D, Weisbart RH, Nishimura RN, Sharp FR. Recombinant Fv-Hsp70 protein mediates neuroprotection after focal cerebral ischemia in rats. Stroke. 2010 Mar; 41(3):538-43. PMID: 20075343.
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    81. Liu DZ, Ander BP, Sharp FR. Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of central nervous system diseases. Neurobiol Dis. 2010 Mar; 37(3):549-57. PMID: 19944161.
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    82. Stamova B, Green PG, Tian Y, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Teng J, Gregg JP, Ashwood P, Van de Water J, Sharp FR. Correlations between gene expression and mercury levels in blood of boys with and without autism. Neurotox Res. 2011 Jan; 19(1):31-48. PMID: 19937285.
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    83. Tian Y, Green PG, Stamova B, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Gregg JP, Ashwood P, Jickling G, Van de Water J, Sharp FR. Correlations of gene expression with blood lead levels in children with autism compared to typically developing controls. Neurotox Res. 2011 Jan; 19(1):1-13. PMID: 19921347.
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    84. Liu DZ, Ander BP, Sharp FR. WITHDRAWN: Cell cycle Inhibition as a Strategy for Treatment of Central Nervous System Diseases. Recent Pat Nanotechnol. 2009 Nov 01. PMID: 19534699.
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    85. Zhan X, Ander BP, Jickling G, Turner R, Stamova B, Xu H, Liu D, Davis RR, Sharp FR. Brief focal cerebral ischemia that simulates transient ischemic attacks in humans regulates gene expression in rat peripheral blood. J Cereb Blood Flow Metab. 2010 Jan; 30(1):110-8. PMID: 19738631.
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    86. Liu DZ, Tian Y, Ander BP, Xu H, Stamova BS, Zhan X, Turner RJ, Jickling G, Sharp FR. Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab. 2010 Jan; 30(1):92-101. PMID: 19724284.
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    87. Stamova BS, Apperson M, Walker WL, Tian Y, Xu H, Adamczy P, Zhan X, Liu DZ, Ander BP, Liao IH, Gregg JP, Turner RJ, Jickling G, Lit L, Sharp FR. Identification and validation of suitable endogenous reference genes for gene expression studies in human peripheral blood. BMC Med Genomics. 2009 Aug 05; 2:49. PMID: 19656400.
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    88. Hendren RL, Bertoglio K, Ashwood P, Sharp F. Mechanistic biomarkers for autism treatment. Med Hypotheses. 2009 Dec; 73(6):950-4. PMID: 19619951.
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    89. Lit L, Sharp FR, Apperson M, Liu DZ, Walker WL, Liao I, Xu H, Ander BP, Wong B. Corticosteroid effects on blood gene expression in Duchenne muscular dystrophy. Pharmacogenomics J. 2009 Dec; 9(6):411-8. PMID: 19488064.
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    90. Lu A, Clark JF, Broderick JP, Pyne-Geithman GJ, Wagner KR, Khatri P, Tomsick T, Sharp FR. Mechanical reperfusion is associated with post-ischemic hemorrhage in rat brain. Exp Neurol. 2009 Apr; 216(2):407-12. PMID: 19162014.
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    91. Wong B, Gilbert DL, Walker WL, Liao IH, Lit L, Stamova B, Jickling G, Apperson M, Sharp FR. Gene expression in blood of subjects with Duchenne muscular dystrophy. Neurogenetics. 2009 Apr; 10(2):117-25. PMID: 19067001.
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    92. Lu A, Clark JF, Ran R, Pyne-Geithman G, Wagner KR, Millhorn DE, Sharp FR. Down-regulation of interleukin 7 mRNA by hypoxia is calcium dependent. Neurol Res. 2009 Jun; 31(5):545-9. PMID: 19055876.
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    93. Walker WL, Liao IH, Gilbert DL, Wong B, Pollard KS, McCulloch CE, Lit L, Sharp FR. Empirical Bayes accomodation of batch-effects in microarray data using identical replicate reference samples: application to RNA expression profiling of blood from Duchenne muscular dystrophy patients. BMC Genomics. 2008 Oct 20; 9:494. PMID: 18937867.
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    94. Enstrom AM, Lit L, Onore CE, Gregg JP, Hansen RL, Pessah IN, Hertz-Picciotto I, Van de Water JA, Sharp FR, Ashwood P. Altered gene expression and function of peripheral blood natural killer cells in children with autism. Brain Behav Immun. 2009 Jan; 23(1):124-33. PMID: 18762240.
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    95. Zhan X, Kim C, Sharp FR. Very brief focal ischemia simulating transient ischemic attacks (TIAs) can injure brain and induce Hsp70 protein. Brain Res. 2008 Oct 09; 1234:183-97. PMID: 18708034.
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    96. Lit L, Enstrom A, Sharp FR, Gilbert DL. Age-related gene expression in Tourette syndrome. J Psychiatr Res. 2009 Jan; 43(3):319-30. PMID: 18485367.
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    97. Xu H, Tang Y, Liu DZ, Ran R, Ander BP, Apperson M, Liu XS, Khoury JC, Gregg JP, Pancioli A, Jauch EC, Wagner KR, Verro P, Broderick JP, Sharp FR. Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic stroke. J Cereb Blood Flow Metab. 2008 Jul; 28(7):1320-8. PMID: 18382470.
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    98. Liu DZ, Cheng XY, Ander BP, Xu H, Davis RR, Gregg JP, Sharp FR. Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons. Neurobiol Dis. 2008 May; 30(2):201-11. PMID: 18343677.
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    99. Robbins SH, Walzer T, Dembélé D, Thibault C, Defays A, Bessou G, Xu H, Vivier E, Sellars M, Pierre P, Sharp FR, Chan S, Kastner P, Dalod M. Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol. 2008 Jan 24; 9(1):R17. PMID: 18218067.
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    100. Sharp F, Liu DZ, Zhan X, Ander BP. Intracerebral hemorrhage injury mechanisms: glutamate neurotoxicity, thrombin, and Src. Acta Neurochir Suppl. 2008; 105:43-6. PMID: 19066080.
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    101. Lu A, Clark JF, Broderick JP, Pyne-Geithman GJ, Wagner KR, Ran R, Khatri P, Tomsick T, Sharp FR. Reperfusion activates metalloproteinases that contribute to neurovascular injury. Exp Neurol. 2008 Apr; 210(2):549-59. PMID: 18187134.
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    102. Gregg JP, Lit L, Baron CA, Hertz-Picciotto I, Walker W, Davis RA, Croen LA, Ozonoff S, Hansen R, Pessah IN, Sharp FR. Gene expression changes in children with autism. Genomics. 2008 Jan; 91(1):22-9. PMID: 18006270.
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    103. Lit L, Gilbert DL, Walker W, Sharp FR. A subgroup of Tourette's patients overexpress specific natural killer cell genes in blood: a preliminary report. Am J Med Genet B Neuropsychiatr Genet. 2007 Oct 05; 144B(7):958-63. PMID: 17503477.
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    104. Ran R, Pan R, Lu A, Xu H, Davis RR, Sharp FR. A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis. Mol Cell Neurosci. 2007 Nov; 36(3):392-407. PMID: 17888676.
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    105. Sharp FR, Hendren RL. Psychosis: atypical limbic epilepsy versus limbic hyperexcitability with onset at puberty? Epilepsy Behav. 2007 Jun; 10(4):515-20. PMID: 17416210.
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    106. Ardizzone TD, Zhan X, Ander BP, Sharp FR. SRC kinase inhibition improves acute outcomes after experimental intracerebral hemorrhage. Stroke. 2007 May; 38(5):1621-5. PMID: 17395859.
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    107. Sharp FR, Xu H, Lit L, Walker W, Pinter J, Apperson M, Verro P. Genomic profiles of stroke in blood. Stroke. 2007 Feb; 38(2 Suppl):691-3. PMID: 17261717.
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    108. Corbett BA, Kantor AB, Schulman H, Walker WL, Lit L, Ashwood P, Rocke DM, Sharp FR. A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins. Mol Psychiatry. 2007 Mar; 12(3):292-306. PMID: 17189958.
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    109. Sharp FR, Xu H, Lit L, Walker W, Apperson M, Gilbert DL, Glauser TA, Wong B, Hershey A, Liu DZ, Pinter J, Zhan X, Liu X, Ran R. The future of genomic profiling of neurological diseases using blood. Arch Neurol. 2006 Nov; 63(11):1529-36. PMID: 17101821.
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    110. Sharp FR, Lit L, Xu H, Apperson M, Walker W, Wong B, Gilbert DL, Hershey A, Glauser TA. Genomics of brain and blood: progress and pitfalls. Epilepsia. 2006 Oct; 47(10):1603-7. PMID: 17054680.
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    111. Adhami F, Liao G, Morozov YM, Schloemer A, Schmithorst VJ, Lorenz JN, Dunn RS, Vorhees CV, Wills-Karp M, Degen JL, Davis RJ, Mizushima N, Rakic P, Dardzinski BJ, Holland SK, Sharp FR, Kuan CY. Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol. 2006 Aug; 169(2):566-83. PMID: 16877357.
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    112. Pritchard LM, Logue AD, Taylor BC, Ahlbrand R, Welge JA, Tang Y, Sharp FR, Richtand NM. Relative expression of D3 dopamine receptor and alternative splice variant D3nf mRNA in high and low responders to novelty. Brain Res Bull. 2006 Oct 16; 70(4-6):296-303. PMID: 17027765.
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    113. Vexler ZS, Sharp FR, Feuerstein GZ, Ashwal S, Thoresen M, Yager JY, Ferriero DM. Translational stroke research in the developing brain. Pediatr Neurol. 2006 Jun; 34(6):459-63. PMID: 16765824.
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    114. Du X, Tang Y, Xu H, Lit L, Walker W, Ashwood P, Gregg JP, Sharp FR. Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome. Genomics. 2006 Jun; 87(6):693-703. PMID: 16546348.
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    115. Clark JF, Sharp FR. Bilirubin oxidation products (BOXes) and their role in cerebral vasospasm after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2006 Oct; 26(10):1223-33. PMID: 16467784.
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    116. Lu A, Tang Y, Ran R, Ardizzone TL, Wagner KR, Sharp FR. Brain genomics of intracerebral hemorrhage. J Cereb Blood Flow Metab. 2006 Feb; 26(2):230-52. PMID: 16034371.
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    117. Tang Y, Xu H, Du X, Lit L, Walker W, Lu A, Ran R, Gregg JP, Reilly M, Pancioli A, Khoury JC, Sauerbeck LR, Carrozzella JA, Spilker J, Clark J, Wagner KR, Jauch EC, Chang DJ, Verro P, Broderick JP, Sharp FR. Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. J Cereb Blood Flow Metab. 2006 Aug; 26(8):1089-102. PMID: 16395289.
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    118. Nishimura RN, Sharp FR. Heat shock proteins and neuromuscular disease. Muscle Nerve. 2005 Dec; 32(6):693-709. PMID: 15962334.
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    119. Dickerson J, Sharp FR. Atypical antipsychotics and a Src kinase inhibitor (PP1) prevent cortical injury produced by the psychomimetic, noncompetitive NMDA receptor antagonist MK-801. Neuropsychopharmacology. 2006 Jul; 31(7):1420-30. PMID: 16123741.
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    120. Zhang D, Zhang L, Tang Y, Zhang Q, Lou D, Sharp FR, Zhang J, Xu M. Repeated cocaine administration induces gene expression changes through the dopamine D1 receptors. Neuropsychopharmacology. 2005 Aug; 30(8):1443-54. PMID: 15770241.
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    121. Ran R, Xu H, Lu A, Bernaudin M, Sharp FR. Hypoxia preconditioning in the brain. Dev Neurosci. 2005 Mar-Aug; 27(2-4):87-92. PMID: 16046841.
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    122. Tang Y, Gilbert DL, Glauser TA, Hershey AD, Sharp FR. Blood gene expression profiling of neurologic diseases: a pilot microarray study. Arch Neurol. 2005 Feb; 62(2):210-5. PMID: 15710849.
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    123. Tang Y, Lu A, Ran R, Aronow BJ, Schorry EK, Hopkin RJ, Gilbert DL, Glauser TA, Hershey AD, Richtand NW, Privitera M, Dalvi A, Sahay A, Szaflarski JP, Ficker DM, Ratner N, Sharp FR. Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1. Brain Res Mol Brain Res. 2004 Dec 20; 132(2):155-67. PMID: 15582155.
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    124. Tang Y, Schapiro MB, Franz DN, Patterson BJ, Hickey FJ, Schorry EK, Hopkin RJ, Wylie M, Narayan T, Glauser TA, Gilbert DL, Hershey AD, Sharp FR. Blood expression profiles for tuberous sclerosis complex 2, neurofibromatosis type 1, and Down's syndrome. Ann Neurol. 2004 Dec; 56(6):808-14. PMID: 15562430.
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    125. Glass TF, Reeves B, Sharp FR. The impact of excitotoxic blockade on the evolution of injury following combined mechanical and hypoxic insults in primary rat neuronal culture. Neurobiol Dis. 2004 Dec; 17(3):378-84. PMID: 15571974.
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    126. Carter K, Dickerson J, Schoepp DD, Reilly M, Herring N, Williams J, Sallee FR, Sharp JW, Sharp FR. The mGlu2/3 receptor agonist LY379268 injected into cortex or thalamus decreases neuronal injury in retrosplenial cortex produced by NMDA receptor antagonist MK-801: possible implications for psychosis. Neuropharmacology. 2004 Dec; 47(8):1135-45. PMID: 15567423.
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    127. Kuan CY, Schloemer AJ, Lu A, Burns KA, Weng WL, Williams MT, Strauss KI, Vorhees CV, Flavell RA, Davis RJ, Sharp FR, Rakic P. Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. J Neurosci. 2004 Nov 24; 24(47):10763-72. PMID: 15564594.
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    128. Hershey AD, Tang Y, Powers SW, Kabbouche MA, Gilbert DL, Glauser TA, Sharp FR. Genomic abnormalities in patients with migraine and chronic migraine: preliminary blood gene expression suggests platelet abnormalities. Headache. 2004 Nov-Dec; 44(10):994-1004. PMID: 15546262.
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    129. Weinstein PR, Hong S, Sharp FR. Molecular identification of the ischemic penumbra. Stroke. 2004 Nov; 35(11 Suppl 1):2666-70. PMID: 15486332.
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    130. Ardizzone TD, Lu A, Wagner KR, Tang Y, Ran R, Sharp FR. Glutamate receptor blockade attenuates glucose hypermetabolism in perihematomal brain after experimental intracerebral hemorrhage in rat. Stroke. 2004 Nov; 35(11):2587-91. PMID: 15375303.
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    131. Kim YS, Honkaniemi J, Sharp FR, Täuber MG. Expression of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the brain during experimental group B streptococcal meningitis. Brain Res Mol Brain Res. 2004 Sep 10; 128(1):95-102. PMID: 15337322.
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    132. Yamauchi T, Lin Y, Sharp FR, Noble-Haeusslein LJ. Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord. J Neurotrauma. 2004 Aug; 21(8):1017-30. PMID: 15319001.
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    133. Ran R, Lu A, Zhang L, Tang Y, Zhu H, Xu H, Feng Y, Han C, Zhou G, Rigby AC, Sharp FR. Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling. Genes Dev. 2004 Jun 15; 18(12):1466-81. PMID: 15198984.
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    134. Sharp FR, Bernaudin M. HIF1 and oxygen sensing in the brain. Nat Rev Neurosci. 2004 Jun; 5(6):437-48. PMID: 15152194.
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    135. Kalkkila JP, Sharp FR, Kärkkäinen I, Reilly M, Lu A, Solway K, Murrel M, Honkaniemi J. Cloning and expression of short interspersed elements B1 and B2 in ischemic brain. Eur J Neurosci. 2004 Mar; 19(5):1199-206. PMID: 15016078.
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    136. Tang Y, Glauser TA, Gilbert DL, Hershey AD, Privitera MD, Ficker DM, Szaflarski JP, Sharp FR. Valproic acid blood genomic expression patterns in children with epilepsy - a pilot study. Acta Neurol Scand. 2004 Mar; 109(3):159-68. PMID: 14763951.
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    137. Bernaudin M, Sharp FR. Methods to detect hypoxia-induced ischemic tolerance in the brain. Methods Enzymol. 2004; 381:399-416. PMID: 15063689.
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    138. Ran R, Zhou G, Lu A, Zhang L, Tang Y, Rigby AC, Sharp FR. Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survival. Cell Stress Chaperones. 2004; 9(3):229-42. PMID: 15544161.
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    139. Sharp FR, Ran R, Lu A, Tang Y, Strauss KI, Glass T, Ardizzone T, Bernaudin M. Hypoxic preconditioning protects against ischemic brain injury. NeuroRx. 2004 Jan; 1(1):26-35. PMID: 15717005.
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    140. Lu A, Tang Y, Ran R, Clark JF, Aronow BJ, Sharp FR. Genomics of the periinfarction cortex after focal cerebral ischemia. J Cereb Blood Flow Metab. 2003 Jul; 23(7):786-810. PMID: 12843783.
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    141. Kokubo Y, Liu J, Rajdev S, Kayama T, Sharp FR, Weinstein PR. Differential cerebral protein synthesis and heat shock protein 70 expression in the core and penumbra of rat brain after transient focal ischemia. Neurosurgery. 2003 Jul; 53(1):186-90; discussion 190-1. PMID: 12823888.
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    142. Wagner KR, Sharp FR, Ardizzone TD, Lu A, Clark JF. Heme and iron metabolism: role in cerebral hemorrhage. J Cereb Blood Flow Metab. 2003 Jun; 23(6):629-52. PMID: 12796711.
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    143. Chang EF, Wong RJ, Vreman HJ, Igarashi T, Galo E, Sharp FR, Stevenson DK, Noble-Haeusslein LJ. Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. J Neurosci. 2003 May 01; 23(9):3689-96. PMID: 12736340.
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    144. Tang Y, Nee AC, Lu A, Ran R, Sharp FR. Blood genomic expression profile for neuronal injury. J Cereb Blood Flow Metab. 2003 Mar; 23(3):310-9. PMID: 12621306.
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    145. Mancuso A, Derugin N, Hara K, Marsh TA, Kong D, Sharp FR, Weinstein PR. Cyclooxygenase-2 mRNA expression is associated with c-fos mRNA expression and transient water ADC reduction detected with diffusion MRI during acute focal ischemia in rats. Brain Res. 2003 Jan 24; 961(1):121-30. PMID: 12535784.
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    146. Glass TF, Reeves B, Sharp FR. Modeling both the mechanical and hypoxic features of traumatic brain injury in vitro in rats. Neurosci Lett. 2002 Aug 09; 328(2):133-6. PMID: 12133573.
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    147. Bernaudin M, Tang Y, Reilly M, Petit E, Sharp FR. Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J Biol Chem. 2002 Oct 18; 277(42):39728-38. PMID: 12145288.
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    148. Cao G, Pei W, Ge H, Liang Q, Luo Y, Sharp FR, Lu A, Ran R, Graham SH, Chen J. In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis. J Neurosci. 2002 Jul 01; 22(13):5423-31. PMID: 12097494.
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    149. Kokubo Y, Matson GB, Liu J, Mancuso A, Kayama T, Sharp FR, Weinstein PR. Correlation between changes in apparent diffusion coefficient and induction of heat shock protein, cell-specific injury marker expression, and protein synthesis reduction on diffusion-weighted magnetic resonance images after temporary focal cerebral ischemia in rats. J Neurosurg. 2002 Jun; 96(6):1084-93. PMID: 12066911.
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    150. Tang Y, Lu A, Aronow BJ, Wagner KR, Sharp FR. Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia. Eur J Neurosci. 2002 Jun; 15(12):1937-52. PMID: 12099900.
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    151. Lu A, Ran R, Parmentier-Batteur S, Nee A, Sharp FR. Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia. J Neurochem. 2002 Apr; 81(2):355-64. PMID: 12064483.
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    152. Clark JF, Reilly M, Sharp FR. Oxidation of bilirubin produces compounds that cause prolonged vasospasm of rat cerebral vessels: a contributor to subarachnoid hemorrhage-induced vasospasm. J Cereb Blood Flow Metab. 2002 Apr; 22(4):472-8. PMID: 11919518.
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    153. Sharp FR, Liu J, Bernabeu R. Neurogenesis following brain ischemia. Brain Res Dev Brain Res. 2002 Mar 31; 134(1-2):23-30. PMID: 11947934.
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    154. Murphy P, Sharp A, Shin J, Gavrilyuk V, Dello Russo C, Weinberg G, Sharp FR, Lu A, Heneka MT, Feinstein DL. Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis. J Neurosci Res. 2002 Feb 15; 67(4):461-70. PMID: 11835313.
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    155. Lu A, Ran RQ, Clark J, Reilly M, Nee A, Sharp FR. 17-beta-estradiol induces heat shock proteins in brain arteries and potentiates ischemic heat shock protein induction in glia and neurons. J Cereb Blood Flow Metab. 2002 Feb; 22(2):183-95. PMID: 11823716.
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    156. Tang Y, Lu A, Aronow BJ, Sharp FR. Blood genomic responses differ after stroke, seizures, hypoglycemia, and hypoxia: blood genomic fingerprints of disease. Ann Neurol. 2001 Dec; 50(6):699-707. PMID: 11761467.
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    157. Sharp FR, Tomitaka M, Bernaudin M, Tomitaka S. Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia? Trends Neurosci. 2001 Jun; 24(6):330-4. PMID: 11356504.
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    158. Bergeron M, Sharp FR. Measurement of expression of the HSP70 protein family. Curr Protoc Toxicol. 2001 May; Chapter 2:Unit 2.9. PMID: 23045049.
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    159. Bergeron M, Honkaniemi J, Sharp FR. Northern blot analysis of RNA. Curr Protoc Toxicol. 2001 May; Appendix 3:A.3E.1-.13. PMID: 20972965.
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    160. Liu J, Bartels M, Lu A, Sharp FR. Microglia/macrophages proliferate in striatum and neocortex but not in hippocampus after brief global ischemia that produces ischemic tolerance in gerbil brain. J Cereb Blood Flow Metab. 2001 Apr; 21(4):361-73. PMID: 11323522.
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    161. Sharp FR, Bergeron M, Bernaudin M. Hypoxia-inducible factor in brain. Adv Exp Med Biol. 2001; 502:273-91. PMID: 11950144.
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    162. Sharp FR, Bernaudin M, Bartels M, Wagner KR. Glial expression of heat shock proteins (HSPs) and oxygen-regulated proteins (ORPs). Prog Brain Res. 2001; 132:427-40. PMID: 11545009.
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    163. Mancuso A, Derugin N, Hara K, Sharp FR, Weinstein PR. Mild hypothermia decreases the incidence of transient ADC reduction detected with diffusion MRI and expression of c-fos and hsp70 mRNA during acute focal ischemia in rats. Brain Res. 2000 Dec 22; 887(1):34-45. PMID: 11134587.
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    164. Mautes AE, Bergeron M, Sharp FR, Panter SS, Weinzierl M, Guenther K, Noble LJ. Sustained induction of heme oxygenase-1 in the traumatized spinal cord. Exp Neurol. 2000 Dec; 166(2):254-65. PMID: 11085891.
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    165. Bernabeu R, Sharp FR. NMDA and AMPA/kainate glutamate receptors modulate dentate neurogenesis and CA3 synapsin-I in normal and ischemic hippocampus. J Cereb Blood Flow Metab. 2000 Dec; 20(12):1669-80. PMID: 11129783.
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    166. Honkaniemi J, Zhang JS, Longo FM, Sharp FR. Stress induces zinc finger immediate early genes in the rat adrenal gland. Brain Res. 2000 Sep 22; 877(2):203-8. PMID: 10986333.
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    167. Tolliver BK, Sganga MW, Sharp FR. Suppression of c-fos induction in the nucleus accumbens prevents acquisition but not expression of morphine-conditioned place preference. Eur J Neurosci. 2000 Sep; 12(9):3399-406. PMID: 10998122.
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    168. Lessell S. Levodopa toxicity in Parkinson disease. Arch Neurol. 2000 Sep; 57(9):1382. PMID: 10987914.
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    169. Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, Sharp FR. Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann Neurol. 2000 Sep; 48(3):285-96. PMID: 10976634.
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    170. Liu J, Ying W, Massa S, Duriez PJ, Swanson RA, Poirier GG, Sharp FR. Effects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains. Brain Res Mol Brain Res. 2000 Aug 14; 80(1):7-16. PMID: 11039724.
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    171. Rapp JH, Pan XM, Sharp FR, Shah DM, Wille GA, Velez PM, Troyer A, Higashida RT, Saloner D. Atheroemboli to the brain: size threshold for causing acute neuronal cell death. J Vasc Surg. 2000 Jul; 32(1):68-76. PMID: 10876208.
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    172. Sharp FR, Lu A, Tang Y, Millhorn DE. Multiple molecular penumbras after focal cerebral ischemia. J Cereb Blood Flow Metab. 2000 Jul; 20(7):1011-32. PMID: 10908035.
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    173. Rajdev S, Hara K, Kokubo Y, Mestril R, Dillmann W, Weinstein PR, Sharp FR. Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction. Ann Neurol. 2000 Jun; 47(6):782-91. PMID: 10852544.
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    174. Tomitaka M, Tomitaka S, Rajdev S, Sharp FR. Fluoxetine prevents PCP- and MK801-induced HSP70 expression in injured limbic cortical neurons of rats. Biol Psychiatry. 2000 May 01; 47(9):836-41. PMID: 10812043.
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    175. Tomitaka S, Tomitaka M, Tolliver BK, Sharp FR. Bilateral blockade of NMDA receptors in anterior thalamus by dizocilpine (MK-801) injures pyramidal neurons in rat retrosplenial cortex. Eur J Neurosci. 2000 Apr; 12(4):1420-30. PMID: 10762370.
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    176. Joelson E, Ruthrauff B, Ali F, Lindeman N, Sharp FR. Multifocal dural enhancement associated with temporal arteritis. Arch Neurol. 2000 Jan; 57(1):119-22. PMID: 10634458.
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    177. Rajdev S, Sharp FR. Stress proteins as molecular markers of neurotoxicity. Toxicol Pathol. 2000 Jan-Feb; 28(1):105-12. PMID: 10668996.
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    178. Bergeron M, Yu AY, Solway KE, Semenza GL, Sharp FR. Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur J Neurosci. 1999 Dec; 11(12):4159-70. PMID: 10594641.
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    179. Mancuso A, Derugin N, Ono Y, Hara K, Sharp FR, Weinstein PR. Transient MRI-detected water apparent diffusion coefficient reduction correlates with c-fos mRNA but not hsp70 mRNA induction during focal cerebral ischemia in rats. Brain Res. 1999 Aug 21; 839(1):7-22. PMID: 10482794.
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    180. Sharp FR, Massa SM, Swanson RA. Heat-shock protein protection. Trends Neurosci. 1999 Mar; 22(3):97-9. PMID: 10199631.
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    181. Turner CP, Panter SS, Sharp FR. Anti-oxidants prevent focal rat brain injury as assessed by induction of heat shock proteins (HSP70, HO-1/HSP32, HSP47) following subarachnoid injections of lysed blood. Brain Res Mol Brain Res. 1999 Feb 19; 65(1):87-102. PMID: 10036311.
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    182. Bergeron M, Evans SM, Sharp FR, Koch CJ, Lord EM, Ferriero DM. Detection of hypoxic cells with the 2-nitroimidazole, EF5, correlates with early redox changes in rat brain after perinatal hypoxia-ischemia. Neuroscience. 1999; 89(4):1357-66. PMID: 10362320.
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    183. Rajdev S, Fix AS, Sharp FR. Acute phencyclidine neurotoxicity in rat forebrain: induction of haem oxygenase-1 and attenuation by the antioxidant dimethylthiourea. Eur J Neurosci. 1998 Dec; 10(12):3840-52. PMID: 9875361.
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    184. Hara K, Kong DL, Sharp FR, Weinstein PR. Effect of selective inhibition of cyclooxygenase 2 on temporary focal cerebral ischemia in rats. Neurosci Lett. 1998 Oct 30; 256(1):53-6. PMID: 9832215.
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    185. Sato S, Gobbel GT, Honkaniemi J, Li Y, Kondo T, Murakami K, Sato M, Copin JC, Sharp FR, Chan PH. Decreased expression of bcl-2 and bcl-x mRNA coincides with apoptosis following intracerebral administration of 3-nitropropionic acid. Brain Res. 1998 Oct 12; 808(1):56-64. PMID: 9795133.
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    186. Liu J, Solway K, Messing RO, Sharp FR. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J Neurosci. 1998 Oct 01; 18(19):7768-78. PMID: 9742147.
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    187. Sharp FR. Stress genes protect brain. Ann Neurol. 1998 Oct; 44(4):581-3. PMID: 9778255.
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    188. Mautes AE, Kim DH, Sharp FR, Panter S, Sato M, Maida N, Bergeron M, Guenther K, Noble LJ. Induction of heme oxygenase-1 (HO-1) in the contused spinal cord of the rat. Brain Res. 1998 Jun 08; 795(1-2):17-24. PMID: 9622586.
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    189. Hasegawa K, Litt L, Espanol MT, Sharp FR, Chan PH. Expression of c-fos and hsp70 mRNA in neonatal rat cerebrocortical slices during NMDA-induced necrosis and apoptosis. Brain Res. 1998 Mar 02; 785(2):262-78. PMID: 9518644.
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    190. Turner CP, Bergeron M, Matz P, Zegna A, Noble LJ, Panter SS, Sharp FR. Heme oxygenase-1 is induced in glia throughout brain by subarachnoid hemoglobin. J Cereb Blood Flow Metab. 1998 Mar; 18(3):257-73. PMID: 9498842.
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    191. Bergeron M, Ferriero DM, Sharp FR. Developmental expression of heme oxygenase-1 (HSP32) in rat brain: an immunocytochemical study. Brain Res Dev Brain Res. 1998 Feb 10; 105(2):181-94. PMID: 9541737.
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    192. Richmon JD, Fukuda K, Maida N, Sato M, Bergeron M, Sharp FR, Panter SS, Noble LJ. Induction of heme oxygenase-1 after hyperosmotic opening of the blood-brain barrier. Brain Res. 1998 Jan 05; 780(1):108-18. PMID: 9473615.
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    193. Bontempi B, Sharp FR. Systemic morphine-induced Fos protein in the rat striatum and nucleus accumbens is regulated by mu opioid receptors in the substantia nigra and ventral tegmental area. J Neurosci. 1997 Nov 01; 17(21):8596-612. PMID: 9334431.
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    194. Lan JQ, Chen J, Sharp FR, Simon RP, Graham SH. Induction of heat-shock protein (HSP72) in the cingulate and retrosplenial cortex by drugs that antagonize the effects of excitatory amino acids. Brain Res Mol Brain Res. 1997 Jun; 46(1-2):297-302. PMID: 9191105.
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    195. Honkaniemi J, States BA, Weinstein PR, Espinoza J, Sharp FR. Expression of zinc finger immediate early genes in rat brain after permanent middle cerebral artery occlusion. J Cereb Blood Flow Metab. 1997 Jun; 17(6):636-46. PMID: 9236720.
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    196. Bergeron M, Ferriero DM, Vreman HJ, Stevenson DK, Sharp FR. Hypoxia-ischemia, but not hypoxia alone, induces the expression of heme oxygenase-1 (HSP32) in newborn rat brain. J Cereb Blood Flow Metab. 1997 Jun; 17(6):647-58. PMID: 9236721.
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    197. Hasegawa K, Litt L, Espanol MT, Gregory GA, Sharp FR, Chan PH. Effects of neuroprotective dose of fructose-1,6-bisphosphate on hypoxia-induced expression of c-fos and hsp70 mRNA in neonatal rat cerebrocortical slices. Brain Res. 1997 Mar 07; 750(1-2):1-10. PMID: 9098523.
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    198. Kondo T, Sharp FR, Honkaniemi J, Mikawa S, Epstein CJ, Chan PH. DNA fragmentation and Prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase. J Cereb Blood Flow Metab. 1997 Mar; 17(3):241-56. PMID: 9119897.
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    199. Sato S, Gobbel GT, Li Y, Kondo T, Murakami K, Sato M, Hasegawa K, Copin JC, Honkaniemi J, Sharp FR, Chan PH. Blood-brain barrier disruption, HSP70 expression and apoptosis due to 3-nitropropionic acid, a mitochondrial toxin. Acta Neurochir Suppl. 1997; 70:237-9. PMID: 9416333.
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    200. Matz PG, Weinstein PR, Sharp FR. Heme oxygenase-1 and heat shock protein 70 induction in glia and neurons throughout rat brain after experimental intracerebral hemorrhage. Neurosurgery. 1997 Jan; 40(1):152-60; discussion 160-2. PMID: 8971837.
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    201. Kedaria MB, Menovsky T. Heat shock protein. J Neurosurg. 1997 Jan; 86(1):172. PMID: 8988106.
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    202. Narasimhan P, Sklar R, Murrell M, Swanson RA, Sharp FR. Methylmalonyl-CoA mutase induction by cerebral ischemia and neurotoxicity of the mitochondrial toxin methylmalonic acid. J Neurosci. 1996 Nov 15; 16(22):7336-46. PMID: 8929440.
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    203. Matz PG, Massa SM, Weinstein PR, Turner C, Panter SS, Sharp FR. Focal hyperexpression of hemeoxygenase-1 protein and messenger RNA in rat brain caused by cellular stress following subarachnoid injections of lysed blood. J Neurosurg. 1996 Nov; 85(5):892-900. PMID: 8893729.
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    204. Honkaniemi J, Massa SM, Breckinridge M, Sharp FR. Global ischemia induces apoptosis-associated genes in hippocampus. Brain Res Mol Brain Res. 1996 Nov; 42(1):79-88. PMID: 8915583.
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    205. States BA, Honkaniemi J, Weinstein PR, Sharp FR. DNA fragmentation and HSP70 protein induction in hippocampus and cortex occurs in separate neurons following permanent middle cerebral artery occlusions. J Cereb Blood Flow Metab. 1996 Nov; 16(6):1165-75. PMID: 8898689.
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    206. Kondo T, Murakami K, Honkaniemi J, Sharp FR, Epstein CJ, Chan PH. Expression of hsp70 mRNA is induced in the brain of transgenic mice overexpressing human CuZn-superoxide dismutase following transient global cerebral ischemia. Brain Res. 1996 Oct 21; 737(1-2):321-6. PMID: 8930384.
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    207. Fukuda K, Richmon JD, Sato M, Sharp FR, Panter SS, Noble LJ. Induction of heme oxygenase-1 (HO-1) in glia after traumatic brain injury. Brain Res. 1996 Oct 14; 736(1-2):68-75. PMID: 8930310.
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    208. Wang S, Yang Q, Moller CJ, Sharp FR, Haglid KG. Eliprodil prevents expression of the 70 kDa heat shock protein in MK801-injured neurones. Pharmacol Toxicol. 1996 Sep; 79(3):166-8. PMID: 8884877.
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    209. Näkki R, Sharp FR, Sagar SM, Honkaniemi J. Effects of phencyclidine on immediate early gene expression in the brain. J Neurosci Res. 1996 Jul 01; 45(1):13-27. PMID: 8811509.
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    210. Honkaniemi J, Sharp FR. Global ischemia induces immediate-early genes encoding zinc finger transcription factors. J Cereb Blood Flow Metab. 1996 Jul; 16(4):557-65. PMID: 8964794.
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    211. Matz PG, Sundaresan S, Sharp FR, Weinstein PR. Induction of HSP70 in rat brain following subarachnoid hemorrhage produced by endovascular perforation. J Neurosurg. 1996 Jul; 85(1):138-45. PMID: 8683263.
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    212. Narasimhan P, Swanson RA, Sagar SM, Sharp FR. Astrocyte survival and HSP70 heat shock protein induction following heat shock and acidosis. Glia. 1996 Jun; 17(2):147-59. PMID: 8776581.
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    213. Fukuda K, Aihara N, Sagar SM, Sharp FR, Pitts LH, Honkaniemi J, Noble LJ. Purkinje cell vulnerability to mild traumatic brain injury. J Neurotrauma. 1996 May; 13(5):255-66. PMID: 8797175.
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    214. Longuemare MC, Keung EC, Chun S, Sharp FR, Chan PH, Swanson RA. MK-801 reduces uptake and stimulates efflux of excitatory amino acids via membrane depolarization. Am J Physiol. 1996 May; 270(5 Pt 1):C1398-404. PMID: 8967440.
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    215. Nimura T, Weinstein PR, Massa SM, Panter S, Sharp FR. Heme oxygenase-1 (HO-1) protein induction in rat brain following focal ischemia. Brain Res Mol Brain Res. 1996 Apr; 37(1-2):201-8. PMID: 8738152.
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    216. Matz P, Turner C, Weinstein PR, Massa SM, Panter SS, Sharp FR. Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage. Brain Res. 1996 Mar 25; 713(1-2):211-22. PMID: 8724993.
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    217. Matz P, Weinstein P, States B, Honkaniemi J, Sharp FR. Subarachnoid injections of lysed blood induce the hsp70 stress gene and produce DNA fragmentation in focal areas of the rat brain. Stroke. 1996 Mar; 27(3):504-12; discussion 513. PMID: 8610321.
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    218. Nakki R, Nickolenko J, Chang J, Sagar SM, Sharp FR. Haloperidol prevents ketamine- and phencyclidine-induced HSP70 protein expression but not microglial activation. Exp Neurol. 1996 Feb; 137(2):234-41. PMID: 8635538.
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    219. Näkki R, Sharp FR, Sagar SM. FOS expression in the brainstem and cerebellum following phencyclidine and MK801. J Neurosci Res. 1996 Jan 15; 43(2):203-12. PMID: 8820968.
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    220. Massa SM, Swanson RA, Sharp FR. The stress gene response in brain. Cerebrovasc Brain Metab Rev. 1996; 8(2):95-158. PMID: 8727184.
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    221. Honkaniemi J, Massa SM, Sharp FR. Apoptosis associated genes are induced in gerbil hippocampus following global ischemia. Restor Neurol Neurosci. 1996 Jan 01; 9(4):227-30. PMID: 21551911.
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    222. Richmon JD, Fukuda K, Sharp FR, Noble LJ. Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat. Neurosci Lett. 1995 Dec 29; 202(1-2):1-4. PMID: 8787816.
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    223. Gaspary H, Graham SH, Sagar SM, Sharp FR. HSP70 heat shock protein induction following global ischemia in the rat. Brain Res Mol Brain Res. 1995 Dec 28; 34(2):327-32. PMID: 8750837.
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    224. Mikawa S, Sharp FR, Kamii H, Kinouchi H, Epstein CJ, Chan PK. Expression of c-fos and hsp70 mRNA after traumatic brain injury in transgenic mice overexpressing CuZn-superoxide dismutase. Brain Res Mol Brain Res. 1995 Nov; 33(2):288-94. PMID: 8750888.
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    225. Fukuda K, Panter SS, Sharp FR, Noble LJ. Induction of heme oxygenase-1 (HO-1) after traumatic brain injury in the rat. Neurosci Lett. 1995 Oct 20; 199(2):127-30. PMID: 8584240.
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    226. Sharp FR. Stress proteins are sensitive indicators of injury in the brain produced by ischemia and toxins. J Toxicol Sci. 1995 Sep; 20(4):450-3. PMID: 8531239.
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    227. Brown LL, Sharp FR. Metabolic mapping of rat striatum: somatotopic organization of sensorimotor activity. Brain Res. 1995 Jul 24; 686(2):207-22. PMID: 7583286.
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    228. Hisanaga K, Kure S, Bredesen DE, Ikeda Y, Kohsaka S, Sharp FR. Apoptotic cell death of a temperature-sensitive central neuronal cell line. Brain Res. 1995 Jun 26; 684(1):79-86. PMID: 7583207.
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    229. Massa SM, Longo FM, Zuo J, Wang S, Chen J, Sharp FR. Cloning of rat grp75, an hsp70-family member, and its expression in normal and ischemic brain. J Neurosci Res. 1995 Apr 15; 40(6):807-19. PMID: 7629893.
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    230. Näkki R, Koistinaho J, Sharp FR, Sagar SM. Cerebellar toxicity of phencyclidine. J Neurosci. 1995 Mar; 15(3 Pt 2):2097-108. PMID: 7891155.
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    231. Sharp FR, Liu J, Nickolenko J, Bontempi B. NMDA and D1 receptors mediate induction of c-fos and junB genes in striatum following morphine administration: implications for studies of memory. Behav Brain Res. 1995 Jan 23; 66(1-2):225-30. PMID: 7755894.
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    232. Honkaniemi J, Sagar SM, Pyykönen I, Hicks KJ, Sharp FR. Focal brain injury induces multiple immediate early genes encoding zinc finger transcription factors. Brain Res Mol Brain Res. 1995 Jan; 28(1):157-63. PMID: 7707870.
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    233. Sagar SM, Price KJ, Kasting NW, Sharp FR. Anatomic patterns of Fos immunostaining in rat brain following systemic endotoxin administration. Brain Res Bull. 1995; 36(4):381-92. PMID: 7712198.
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    234. Sharp FR, Rando TA, Greenberg SA, Brown L, Sagar SM. Pseudochoreoathetosis. Movements associated with loss of proprioception. Arch Neurol. 1994 Nov; 51(11):1103-9. PMID: 7980104.
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    235. Kamii H, Kinouchi H, Sharp FR, Epstein CJ, Sagar SM, Chan PH. Expression of c-fos mRNA after a mild focal cerebral ischemia in SOD-1 transgenic mice. Brain Res. 1994 Oct 31; 662(1-2):240-4. PMID: 7859076.
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    236. Sharp FR, Butman M, Koistinaho J, Aardalen K, Nakki R, Massa SM, Swanson RA, Sagar SM. Phencyclidine induction of the hsp 70 stress gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels. Neuroscience. 1994 Oct; 62(4):1079-92. PMID: 7845588.
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    237. Sharp FR. The sense of antisense fos oligonucleotides. Ann Neurol. 1994 Oct; 36(4):555-6. PMID: 7944287.
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    238. Kinouchi H, Sharp FR, Chan PH, Mikawa S, Kamii H, Arai S, Yoshimoto T. MK-801 inhibits the induction of immediate early genes in cerebral cortex, thalamus, and hippocampus, but not in substantia nigra following middle cerebral artery occlusion. Neurosci Lett. 1994 Sep 26; 179(1-2):111-4. PMID: 7845604.
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    239. Kinouchi H, Sharp FR, Chan PH, Koistinaho J, Sagar SM, Yoshimoto T. Induction of c-fos, junB, c-jun, and hsp70 mRNA in cortex, thalamus, basal ganglia, and hippocampus following middle cerebral artery occlusion. J Cereb Blood Flow Metab. 1994 Sep; 14(5):808-17. PMID: 8063876.
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    240. Liu J, Nickolenko J, Sharp FR. Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18):8537-41. PMID: 8078918.
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    241. Swanson RA, Sharp FR. Infarct measurement methodology. J Cereb Blood Flow Metab. 1994 Jul; 14(4):697-8. PMID: 7516936.
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    242. Kamii H, Kinouchi H, Sharp FR, Koistinaho J, Epstein CJ, Chan PH. Prolonged expression of hsp70 mRNA following transient focal cerebral ischemia in transgenic mice overexpressing CuZn-superoxide dismutase. J Cereb Blood Flow Metab. 1994 May; 14(3):478-86. PMID: 8163590.
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    243. Kinouchi H, Sharp FR, Chan PH, Koistinaho J, Sagar SM, Yoshimoto T. Induction of NGFI-A mRNA following middle cerebral artery occlusion in rats: in situ hybridization study. Neurosci Lett. 1994 Apr 25; 171(1-2):163-6. PMID: 8084481.
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    244. Graham SH, Meyerhoff DJ, Bayne L, Sharp FR, Weiner MW. Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy. Ann Neurol. 1994 Apr; 35(4):490-4. PMID: 8154879.
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    245. Ciricillo SP, Hill MP, Gonzalez MF, Smalley S, Morton MT, Sharp FR. Whisker stimulation metabolically activates thalamus following cortical transplantation but not following cortical ablation. Neuroscience. 1994 Apr; 59(4):975-92. PMID: 8058130.
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    246. Berger P, Farrel K, Sharp F, Skolnick P. Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex. Neurosci Lett. 1994 Feb 28; 168(1-2):147-50. PMID: 8028768.
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    247. Sharp FR, Sagar SM. Alterations in gene expression as an index of neuronal injury: heat shock and the immediate early gene response. Neurotoxicology. 1994; 15(1):51-9. PMID: 8090362.
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    248. Swanson RA, Sharp FR. BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke. 1994 Jan; 25(1):225-6. PMID: 7903493.
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    249. Sharp FR, Butman M, Aardalen K, Nickolenko J, Nakki R, Massa SM, Swanson RA, Sagar SM. Neuronal injury produced by NMDA antagonists can be detected using heat shock proteins and can be blocked with antipsychotics. Psychopharmacol Bull. 1994; 30(4):555-60. PMID: 7770620.
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    250. Sharp FR, Kinouchi H, Koistinaho J, Chan PH, Sagar SM. HSP70 heat shock gene regulation during ischemia. Stroke. 1993 Dec; 24(12 Suppl):I72-5. PMID: 8249024.
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    251. Wang S, Longo FM, Chen J, Butman M, Graham SH, Haglid KG, Sharp FR. Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia. Neurochem Int. 1993 Dec; 23(6):575-82. PMID: 8281126.
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    252. Longo FM, Wang S, Narasimhan P, Zhang JS, Chen J, Massa SM, Sharp FR. cDNA cloning and expression of stress-inducible rat hsp70 in normal and injured rat brain. J Neurosci Res. 1993 Oct 15; 36(3):325-35. PMID: 8271311.
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    253. Sharp FR. Transplants for stroke patients? Ann Neurol. 1993 Sep; 34(3):322-3. PMID: 8363348.
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    254. Kinouchi H, Sharp FR, Koistinaho J, Hicks K, Kamii H, Chan PH. Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the 'penumbra' following focal cerebral ischemia in the rat. Brain Res. 1993 Aug 13; 619(1-2):334-8. PMID: 8374789.
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    255. Hisanaga K, Sagar SM, Koistinaho J, Hicks KJ, Sharp FR. VIP-induced stellation and immediate early gene expression in astrocytes: effects of dexamethasone. Neurosci Lett. 1993 Jun 25; 156(1-2):57-60. PMID: 8414190.
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    256. Sharp FR, Butman M, Wang S, Koistinaho J, Graham SH, Sagar SM, Berger P, Longo FM. Heat shock proteins used to show that haloperidol prevents neuronal injury produced by ketamine, MK801, and phencyclidine. Ann N Y Acad Sci. 1993 May 28; 679:288-90. PMID: 8512190.
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    257. Sharp FR. Regulatory genes in regeneration and plasticity. Adv Neurol. 1993; 59:257-61. PMID: 8420110.
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    258. Graham SH, Chen J, Sharp FR, Simon RP. Limiting ischemic injury by inhibition of excitatory amino acid release. J Cereb Blood Flow Metab. 1993 Jan; 13(1):88-97. PMID: 8093250.
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    259. Kinouchi H, Sharp FR, Hill MP, Koistinaho J, Sagar SM, Chan PH. Induction of 70-kDa heat shock protein and hsp70 mRNA following transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab. 1993 Jan; 13(1):105-15. PMID: 8416999.
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    260. Sharp FR, Sagar SM, Swanson RA. Metabolic mapping with cellular resolution: c-fos vs. 2-deoxyglucose. Crit Rev Neurobiol. 1993; 7(3-4):205-28. PMID: 8221912.
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    261. Sharp FR, Hisanaga K, Sagar SM. NMDA receptor blockade prevents translation, but not transcription, of the c-fos gene following stimulation with multiple extracellular signals in cultured cortical neurons: implications for plasticity and molecular memory. NIDA Res Monogr. 1993; 125:172-80. PMID: 8341364.
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    262. Sagar SM, Sharp FR. Early response genes as markers of neuronal activity and growth factor action. Adv Neurol. 1993; 59:273-84. PMID: 8420112.
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    263. Sharp FR, Butman M, Wang S, Koistinaho J, Graham SH, Sagar SM, Noble L, Berger P, Longo FM. Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine. J Neurosci Res. 1992 Dec; 33(4):605-16. PMID: 1484394.
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    264. Swanson RA, Morton MM, Sagar SM, Sharp FR. Sensory stimulation induces local cerebral glycogenolysis: demonstration by autoradiography. Neuroscience. 1992 Nov; 51(2):451-61. PMID: 1465204.
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    265. Hisanaga K, Sagar SM, Sharp FR. Ascorbate neurotoxicity in cortical cell culture. Ann Neurol. 1992 May; 31(5):562-5. PMID: 1596092.
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    266. Hisanaga K, Sagar SM, Sharp FR. N-methyl-D-aspartate antagonists block fos-like protein expression induced via multiple signaling pathways in cultured cortical neurons. J Neurochem. 1992 May; 58(5):1836-44. PMID: 1348524.
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    267. Hisanaga K, Sagar SM, Sharp FR. C-fos induction occurs in cultured cortical neurons and astrocytes via multiple signaling pathways. Prog Brain Res. 1992; 94:189-95. PMID: 1337611.
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    268. Swanson RA, Sharp FR. Zinc toxicity and induction of the 72 kD heat shock protein in primary astrocyte culture. Glia. 1992; 6(3):198-205. PMID: 1335969.
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    269. Swanson RA, Sharp FR. Glucose and infarct size. Neurology. 1991 Dec; 41(12):2013. PMID: 1745369.
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    270. Sharp FR, Jasper P, Hall J, Noble L, Sagar SM. MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex. Ann Neurol. 1991 Dec; 30(6):801-9. PMID: 1838680.
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    271. Ciricillo SF, Jasper MP, Gonzalez MF, Sharp FR. Long experimental durations are required for double label [14C]- and [3H]2-deoxyglucose autoradiographic methods. Brain Res. 1991 Nov 08; 564(1):171-5. PMID: 1777819.
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    272. Sagar SM, Edwards RH, Sharp FR. Epidermal growth factor and transforming growth factor alpha induce c-fos gene expression in retinal Muller cells in vivo. J Neurosci Res. 1991 Aug; 29(4):549-59. PMID: 1791642.
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    273. Sharp FR, Sagar SM, Hicks K, Lowenstein D, Hisanaga K. c-fos mRNA, Fos, and Fos-related antigen induction by hypertonic saline and stress. J Neurosci. 1991 Aug; 11(8):2321-31. PMID: 1908006.
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    274. Sharp FR, Lowenstein D, Simon R, Hisanaga K. Heat shock protein hsp72 induction in cortical and striatal astrocytes and neurons following infarction. J Cereb Blood Flow Metab. 1991 Jul; 11(4):621-7. PMID: 2050750.
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    275. Gonzalez MF, Lowenstein D, Fernyak S, Hisanaga K, Simon R, Sharp FR. Induction of heat shock protein 72-like immunoreactivity in the hippocampal formation following transient global ischemia. Brain Res Bull. 1991 Feb; 26(2):241-50. PMID: 2012984.
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    276. Aronin N, Chase K, Sagar SM, Sharp FR, DiFiglia M. N-methyl-D-aspartate receptor activation in the neostriatum increases c-fos and fos-related antigens selectively in medium-sized neurons. Neuroscience. 1991; 44(2):409-20. PMID: 1834961.
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    277. Sandor R, Gonzalez MF, Moseley M, Sharp FR. Motor deficits are produced by removing some cortical transplants grafted into injured sensorimotor cortex of neonatal rats. J Neural Transplant Plast. 1991; 2(3-4):221-33. PMID: 1782254.
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    278. Lowenstein DH, Simon RP, Sharp FR. The pattern of 72-kDa heat shock protein-like immunoreactivity in the rat brain following flurothyl-induced status epilepticus. Brain Res. 1990 Oct 29; 531(1-2):173-82. PMID: 2289119.
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    279. Sharp JW, Sagar SM, Hisanaga K, Jasper P, Sharp FR. The NMDA receptor mediates cortical induction of fos and fos-related antigens following cortical injury. Exp Neurol. 1990 Sep; 109(3):323-32. PMID: 1698651.
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    280. Aronin N, Sagar SM, Sharp FR, Schwartz WJ. Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei. Proc Natl Acad Sci U S A. 1990 Aug; 87(15):5959-62. PMID: 2116012.
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    281. Hisanaga K, Sharp FR. Marked neurotrophic effects of diffusible substances released from non-target cerebellar cells on thalamic neurons in culture. Brain Res Dev Brain Res. 1990 Jul 01; 54(2):151-60. PMID: 2397583.
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    282. Kilduff TS, Miller JD, Radeke CM, Sharp FR, Heller HC. 14C-2-deoxyglucose uptake in the ground squirrel brain during entrance to and arousal from hibernation. J Neurosci. 1990 Jul; 10(7):2463-75. PMID: 2376782.
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    283. Hisanaga K, Sagar SM, Hicks KJ, Swanson RA, Sharp FR. c-fos proto-oncogene expression in astrocytes associated with differentiation or proliferation but not depolarization. Brain Res Mol Brain Res. 1990 Jun; 8(1):69-75. PMID: 2166202.
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    284. Ferriero DM, Soberano HQ, Simon RP, Sharp FR. Hypoxia-ischemia induces heat shock protein-like (HSP72) immunoreactivity in neonatal rat brain. Brain Res Dev Brain Res. 1990 Apr 01; 53(1):145-50. PMID: 2350881.
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    285. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR. A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab. 1990 Mar; 10(2):290-3. PMID: 1689322.
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    286. Jacobson L, Sharp FR, Dallman MF. Induction of fos-like immunoreactivity in hypothalamic corticotropin-releasing factor neurons after adrenalectomy in the rat. Endocrinology. 1990 Mar; 126(3):1709-19. PMID: 2155109.
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    287. Bredesen DE, Hisanaga K, Sharp FR. Neural transplantation using temperature-sensitive immortalized neural cells: a preliminary report. Ann Neurol. 1990 Feb; 27(2):205-7. PMID: 2156481.
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    288. Swanson RA, Yu AC, Chan PH, Sharp FR. Glutamate increases glycogen content and reduces glucose utilization in primary astrocyte culture. J Neurochem. 1990 Feb; 54(2):490-6. PMID: 1967630.
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    289. Swanson RA, Shiraishi K, Morton MT, Sharp FR. Methionine sulfoximine reduces cortical infarct size in rats after middle cerebral artery occlusion. Stroke. 1990 Feb; 21(2):322-7. PMID: 2305410.
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    290. Gonzalez MF, Sharp FR. Fetal cortical transplants surviving in injured sensorimotor cortex of rats: cellular composition and function. Prog Brain Res. 1990; 82:309-12. PMID: 2127110.
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    291. Hisanaga K, Sharp FR. Diffusible neurotrophic factors for thalamic neurons are released from target neocortex and non-target cerebellum. Prog Brain Res. 1990; 82:67-71. PMID: 2290969.
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    292. Sagar SM, Sharp FR. Light induces a Fos-like nuclear antigen in retinal neurons. Brain Res Mol Brain Res. 1990 Jan; 7(1):17-21. PMID: 2153891.
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    293. Shiraishi K, Sharp FR, Simon RP. Sequential metabolic changes in rat brain following middle cerebral artery occlusion: a 2-deoxyglucose study. J Cereb Blood Flow Metab. 1989 Dec; 9(6):765-73. PMID: 2584273.
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    294. Sharp FR, Griffith J, Gonzalez MF, Sagar SM. Trigeminal nerve section induces Fos-like immunoreactivity (FLI) in brainstem and decreases FLI in sensory cortex. Brain Res Mol Brain Res. 1989 Nov; 6(2-3):217-20. PMID: 2515410.
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    295. Kilduff TS, Radeke CM, Randall TL, Sharp FR, Heller HC. Suprachiasmatic nucleus: phase-dependent activation during the hibernation cycle. Am J Physiol. 1989 Sep; 257(3 Pt 2):R605-12. PMID: 2782463.
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    296. Gonzalez MF, Shiraishi K, Hisanaga K, Sagar SM, Mandabach M, Sharp FR. Heat shock proteins as markers of neural injury. Brain Res Mol Brain Res. 1989 Jul; 6(1):93-100. PMID: 2770455.
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    297. Sharp FR, Gonzalez MF, Sharp JW, Sagar SM. c-fos expression and (14C) 2-deoxyglucose uptake in the caudal cerebellum of the rat during motor/sensory cortex stimulation. J Comp Neurol. 1989 Jun 22; 284(4):621-36. PMID: 2504783.
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    298. Sharp FR, Gonzalez MF, Hisanaga K, Mobley WC, Sagar SM. Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections. Neurosci Lett. 1989 May 22; 100(1-3):117-22. PMID: 2503789.
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    299. Swanson RA, Yu AC, Sharp FR, Chan PH. Regulation of glycogen content in primary astrocyte culture: effects of glucose analogues, phenobarbital, and methionine sulfoximine. J Neurochem. 1989 May; 52(5):1359-65. PMID: 2540267.
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    300. Swanson RA, Sagar SM, Sharp FR. Regional brain glycogen stores and metabolism during complete global ischaemia. Neurol Res. 1989 Mar; 11(1):24-8. PMID: 2565546.
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    301. Mampalam TJ, Gonzalez MF, Weinstein P, Sharp FR. Neuronal changes in fetal cortex transplanted to ischemic adult rat cortex. J Neurosurg. 1988 Dec; 69(6):904-12. PMID: 3193196.
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    302. Graham SH, Sharp FR, Dillon W. Intraoral sensation in patients with brainstem lesions: role of the rostral spinal trigeminal nuclei in pons. Neurology. 1988 Oct; 38(10):1529-33. PMID: 3419595.
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    303. Kilduff TS, Sharp FR, Heller HC. Progressive activation of paratrigeminal nucleus during entrance to hibernation. Am J Physiol. 1988 Jul; 255(1 Pt 2):R178-81. PMID: 3394841.
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    304. Sagar SM, Sharp FR, Curran T. Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science. 1988 Jun 03; 240(4857):1328-31. PMID: 3131879.
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    305. Sharp FR, Gonzalez MF, Morgan CW, Morton MT, Sharp JW. Common fur and mystacial vibrissae parallel sensory pathways: 14 C 2-deoxyglucose and WGA-HRP studies in the rat. J Comp Neurol. 1988 Apr 15; 270(3):446-69. PMID: 3372744.
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    306. Sharp JW, Gonzalez MF, Morton MT, Simon RP, Sharp FR. Decreases of cortical and thalamic glucose metabolism produced by parietal cortex stimulation in the rat. Brain Res. 1988 Jan 12; 438(1-2):357-62. PMID: 3345443.
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    307. Gonzalez MF, Sharp FR, Loken JE. Fetal frontal cortex transplanted to injured motor/sensory cortex of adult rats: reciprocal connections with host thalamus demonstrated with WGA-HRP. Exp Neurol. 1988 Jan; 99(1):154-65. PMID: 2446904.
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    308. Sharp FR, Gonzalez MF, Sagar SM. Fetal frontal cortex transplanted to injured motor/sensory cortex of adult rats. II. VIP-, somatostatin-, and NPY-immunoreactive neurons. J Neurosci. 1987 Oct; 7(10):3002-15. PMID: 2889809.
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    309. Gonzalez MF, Sharp FR. Fetal frontal cortex transplanted to injured motor/sensory cortex of adult rats. I. NADPH-diaphorase neurons. J Neurosci. 1987 Oct; 7(10):2991-3001. PMID: 3668613.
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    310. Selby MJ, Edwards R, Sharp F, Rutter WJ. Mouse nerve growth factor gene: structure and expression. Mol Cell Biol. 1987 Sep; 7(9):3057-64. PMID: 3670305.
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    311. Sagar SM, Sharp FR, Swanson RA. The regional distribution of glycogen in rat brain fixed by microwave irradiation. Brain Res. 1987 Aug 04; 417(1):172-4. PMID: 3304537.
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    312. Gonzalez MF, Sharp FR, Sagar SM. Axotomy increases NADPH-diaphorase staining in rat vagal motor neurons. Brain Res Bull. 1987 Mar; 18(3):417-27. PMID: 3580911.
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    313. Sharp FR, Gonzalez MF. Adult rat motor cortex connections to thalamus following neonatal and juvenile frontal cortical lesions: WGA-HRP and amino acid studies. Brain Res. 1986 Dec; 395(2):169-87. PMID: 3779437.
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    314. Sharp FR, Gonzalez MF. Fetal cortical transplants ameliorate thalamic atrophy ipsilateral to neonatal frontal cortex lesions. Neurosci Lett. 1986 Nov 11; 71(2):247-51. PMID: 3785746.
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    315. Gonzalez MF, Poncelet A, Loken JE, Sharp FR. Quantitative measurement of interresponse times to assess forelimb motor function in rats. Behav Brain Res. 1986 Oct; 22(1):75-84. PMID: 3790238.
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    316. Luyten WH, Sharp FR, Ryan AF. Regional differences of brain glucose metabolic compensation after unilateral labyrinthectomy in rats: a [14C]2-deoxyglucose study. Brain Res. 1986 May 14; 373(1-2):68-80. PMID: 3487372.
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    317. Sharp FR, Gonzalez MF, Ferriero DM, Sagar SM. Injured adult neocortical neurons sprout fibers into surviving fetal frontal cortex transplants: evidence using NADPH-diaphorase staining. Neurosci Lett. 1986 Apr 11; 65(2):204-8. PMID: 3754939.
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    318. Gonzalez MF, Sharp FR, Deutsch JA. Gastric distention increases [14C]2-deoxyglucose uptake in the rat nucleus tractus solitarius. Brain Res. 1986 Mar 26; 369(1-2):395-9. PMID: 3697755.
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    319. McEachron DL, Kripke DF, Sharp FR, Lewy AJ, McClellan DE. Lithium effects on selected circadian rhythms in rats. Brain Res Bull. 1985 Sep; 15(3):347-50. PMID: 4052829.
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    320. Sharp FR, Gonzalez MF. Multiple vibrissae sensory regions in rat cerebellum: a (14C) 2-deoxyglucose study. J Comp Neurol. 1985 Apr 22; 234(4):489-500. PMID: 3988997.
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    321. Gonzalez MF, Sharp FR. Reticular nucleus of rat thalamus is metabolically activated during trained forelimb movements. Brain Res. 1985 Apr 22; 332(2):380-5. PMID: 3995276.
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    322. Gonzalez MF, Sharp FR. Vibrissae tactile stimulation: (14C) 2-deoxyglucose uptake in rat brainstem, thalamus, and cortex. J Comp Neurol. 1985 Jan 22; 231(4):457-72. PMID: 3968249.
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    323. Sharp FR, Gonzalez MF. Fetal frontal cortex transplant (14C) 2-deoxyglucose uptake and histology: survival in cavities of host rat brain motor cortex. Neurology. 1984 Oct; 34(10):1305-11. PMID: 6541302.
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    324. Goodwin PC, Ryan AF, Sharp FR, Woolf NK, Davidson TM. Cochlear deoxyglucose uptake: relationship to stimulus intensity. Hear Res. 1984 Sep; 15(3):215-24. PMID: 6501111.
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    325. Sharp FR, Ryan AF. Regional (14C) 2-deoxyglucose uptake during forelimb movements evoked by rat motor cortex stimulation: pons, cerebellum, medulla, spinal cord, muscle. J Comp Neurol. 1984 Apr 01; 224(2):286-306. PMID: 19180816.
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    326. Sharp FR. Regional (14C) 2-deoxyglucose uptake during forelimb movements evoked by rat motor cortex stimulation: cortex, diencephalon, midbrain. J Comp Neurol. 1984 Apr 01; 224(2):259-85. PMID: 19180815.
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    327. Woolf NK, Sharp FR, Davidson TM, Ryan AF. Cochlear and middle ear effects on metabolism in the central auditory pathway during silence: a 2-deoxyglucose study. Brain Res. 1983 Sep 05; 274(1):119-27. PMID: 6616248.
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    328. Kilduff TS, George CP, Sharp FR, Heller HC. Metabolic activation of the brachium conjunctivum during induced hypothermia. Brain Res. 1983 Jun 13; 269(1):168-71. PMID: 6871697.
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    329. Sharp FR, Kilduff TS, Bzorgchami S, Heller HC, Ryan AF. The relationship of local cerebral glucose utilization to optical density ratios. Brain Res. 1983 Mar 14; 263(1):97-103. PMID: 6839171.
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    330. Sharp FR, Bzorgchami S, Kilduff T. Focal increases of white matter glucose utilization produced by electrical stimulation of rat motor cortex. J Cereb Blood Flow Metab. 1983 Mar; 3(1):67-70. PMID: 6822620.
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    331. Kilduff TS, Sharp FR, Heller HC. Relative 2-deoxyglucose uptake of the paratrigeminal nucleus increases during hibernation. Brain Res. 1983 Feb 28; 262(1):117-23. PMID: 6831223.
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    332. Bigley GK, Sharp FR. Reversible alexia without agraphia due to migraine. Arch Neurol. 1983 Feb; 40(2):114-5. PMID: 6824441.
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    333. George CP, Kilduff TS, Sharp FR, Heller HC. Autoradiographic patterns of hippocampal metabolism during induced hypothermia. Neurosci Lett. 1982 Dec 31; 34(3):233-9. PMID: 7162705.
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    334. Ryan AF, Sharp FR. Localization of [3H]2-deoxyglucose at the cellular level using freeze-dried tissue and dry-looped emulsion. Brain Res. 1982 Dec 02; 252(1):177-80. PMID: 6293653.
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    335. Sharp FR, Evans KL. Bilateral [14C]2-deoxyglucose uptake by motor pathways after unilateral neonatal cortex lesions in the rat. Brain Res. 1982 Dec; 282(1):1-11. PMID: 6186341.
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    336. Sharp FR, Evans K, Bolger E. Local cerebral glucose utilization in the symptomatic thiamine-deficient rat: increases in fornix and pyramidal tract. Neurology. 1982 Aug; 32(8):808-14. PMID: 7201576.
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    337. Sharp FR, Evans K. Regional (14C) 2-deoxyglucose uptake during vibrissae movements evoked by rat motor cortex stimulation. J Comp Neurol. 1982 Jul 01; 208(3):255-87. PMID: 7119161.
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    338. Ryan AF, Woolf NK, Sharp FR. Tonotopic organization in the central auditory pathway of the Mongolian gerbil: a 2-deoxyglucose study. J Comp Neurol. 1982 Jun 01; 207(4):369-80. PMID: 7119149.
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    339. Ryan AF, Goodwin P, Woolf NK, Sharp F. Auditory stimulation alters the pattern of 2-deoxyglucose uptake in the inner ear. Brain Res. 1982 Feb 25; 234(2):213-25. PMID: 7059827.
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    340. Kilduff TS, Sharp FR, Heller HC. [14C]2-deoxyglucose uptake in ground squirrel brain during hibernation. J Neurosci. 1982 Feb; 2(2):143-57. PMID: 6278102.
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    341. Sharp FR, Bolger E, Evans K. Thiamine deficiency limits glucose utilization and glial proliferation in brain lesions of symptomatic rats. J Cereb Blood Flow Metab. 1982; 2(2):203-7. PMID: 7076732.
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    342. Ryan AF, Woolf NK, Sharp FR. Functional ontogeny in the central auditory pathway of the Mongolian gerbil. A 2-deoxyglucose study. Exp Brain Res. 1982; 47(3):428-36. PMID: 7128710.
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    343. Sharp FR, Ryan AF, Goodwin P, Woolf NK. Increasing intensities of wide band noise increase [14C]2-deoxyglucose uptake in gerbil central auditory structures. Brain Res. 1981 Dec 28; 230(1-2):87-96. PMID: 7317792.
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    344. Schim J, Lyden P, Sharp FR. Increased subcortical and laminar cortical 2-deoxy[14C]glucose uptake during cerebellar stimulation. Exp Neurol. 1981 Nov; 74(2):499-518. PMID: 7297632.
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    345. Sander JE, Sharp FR. Lumbosacral plexus neuritis. Neurology. 1981 Apr; 31(4):470-3. PMID: 7194440.
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    346. Hansen KS, Sharp FR. Gasoline sniffing, lead poisoning, and myoclonus. JAMA. 1978 Sep 22; 240(13):1375-6. PMID: 682330.
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    347. Schwartz WJ, Sharp FR. Autoradiographic maps of regional brain glucose consumption in resting, awake rats using (14C) 2-deoxyglucose. J Comp Neurol. 1978 Jan 15; 177(2):335-59. PMID: 621295.
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    348. Sharp FR, Schwartz WJ. Proposed effects of brain noradrenaline on neuronal activity and cerebral blood flow during REM sleep. Experientia. 1977 Dec 15; 33(12):1618-20. PMID: 201486.
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    349. Sharp FR, Kauer JS, Shepherd GM. Laminar analysis of 2-deoxyglucose uptake in olfactory bulb and olfactory cortex of rabbit and rat. J Neurophysiol. 1977 Jul; 40(4):800-13. PMID: 886371.
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    350. Davis RH, Sisco KL, Sharp FR. Protein synthetic activity in nervous tissue from different anatomical regions of lobster. Comp Biochem Physiol B. 1977; 57(1):65-71. PMID: 299629.
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    351. Sharp FR. General motor activity. Neurosci Res Program Bull. 1976 Sep; 14(4):492-6. PMID: 824565.
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    352. Sharp FR. Vestibular stimulation. Neurosci Res Program Bull. 1976 Sep; 14(4):490-2. PMID: 1086445.
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    353. Sharp FR. Improved resolution of the [1-14C]-2-deoxy-D-glucose technique and tissue localization. Neurosci Res Program Bull. 1976 Sep; 14(4):468-73. PMID: 980254.
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    354. Sharp FR, Sokoloff L. Relation of central nervous system glucose metabolism to neuronal structure. Sciatic nerve stimulation. Neurosci Res Program Bull. 1976 Sep; 14(4):476-8. PMID: 980256.
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    355. Sharp FR. Rotation induced increases of glucose uptake in rat vestibular nuclei and vestibulocerebellum. Brain Res. 1976 Jun 25; 110(1):141-51. PMID: 1276945.
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    356. Sharp FR. Relative cerebral glucose uptake of neuronal perikarya and neuropil determined with 2-deoxyglucose in resting and swimming rat. Brain Res. 1976 Jun 25; 110(1):127-39. PMID: 1276944.
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    357. Sharp FR. Activity-related increases of glucose utilization associated with reduced incorporation of glucose into its derivatives. Brain Res. 1976 May 14; 107(3):663-6. PMID: 1268751.
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    358. Schwartz WJ, Sharp FR, Gunn RH, Evarts EV. Lesions of ascending dopaminergic pathways decrease forebrain glucose uptake. Nature. 1976 May 13; 261(5556):155-7. PMID: 1272385.
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    359. Schwartz WJ, Gunn RH, Sharp FR, Evarts EV. Unilateral electrolytic lesions of the substantia nigra cause contralateral circling in rats. Brain Res. 1976 Mar 26; 105(2):358-61. PMID: 1260449.
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    360. Sharp FR, Kauer JS, Shepherd GM. Local sites of activity-related glucose metabolism in rat olfactory bulb during olfactory stimulation. Brain Res. 1975 Nov 21; 98(3):596-600. PMID: 1182541.
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    361. Kennedy C, Des Rosiers MH, Jehle JW, Reivich M, Sharpe F, Sokoloff L. Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with (14C)deoxyglucose. Science. 1975 Mar 07; 187(4179):850-3. PMID: 1114332.
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