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Martha E O'Donnell

Title(s)Professor, Physiology and Membrane Biology
SchoolUniversity of California, Davis
Phone530-752-7626
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. O'Donnell ME, Yuan JX. Pathophysiology of stroke: what do cells of the neurovascular unit have to do with it? Am J Physiol Cell Physiol. 2019 01 01; 316(1):C1. PMID: 30462541.
      View in: PubMed
    2. O'Donnell ME, Yuan JX. Pathophysiology of stroke: the many and varied contributions of brain microvasculature. Am J Physiol Cell Physiol. 2018 09 01; 315(3):C341-C342. PMID: 30110563.
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    3. Glaser N, Sasaki-Russell J, Cohen M, Little C, O'Donnell M, Sall J. Histological and cognitive alterations in adult diabetic rats following an episode of juvenile diabetic ketoacidosis: Evidence of permanent cerebral injury. Neurosci Lett. 2017 05 22; 650:161-167. PMID: 28435047.
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    4. Glaser N, Little C, Lo W, Cohen M, Tancredi D, Wulff H, O'Donnell M. Treatment with the KCa3.1 inhibitor TRAM-34 during diabetic ketoacidosis reduces inflammatory changes in the brain. Pediatr Diabetes. 2017 08; 18(5):356-366. PMID: 27174668.
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    5. Glaser N, Lo W, Tancredi D, Orgain M, Puvenna V, Janigro D, O Donnell M. Levels of S100B in brain and blood of rats with diabetic ketoacidosis. Brain Res. 2015 Oct 22; 1624:536-544. PMID: 26254728.
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    6. Lo W, O'Donnell M, Tancredi D, Orgain M, Glaser N. Diabetic ketoacidosis in juvenile rats is associated with reactive gliosis and activation of microglia in the hippocampus. Pediatr Diabetes. 2016 Mar; 17(2):127-39. PMID: 25594864.
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    7. Chen YJ, Wallace BK, Yuen N, Jenkins DP, Wulff H, O'Donnell ME. Blood-brain barrier KCa3.1 channels: evidence for a role in brain Na uptake and edema in ischemic stroke. Stroke. 2015 Jan; 46(1):237-44. PMID: 25477223.
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    8. O'Donnell ME. Blood-brain barrier Na transporters in ischemic stroke. Adv Pharmacol. 2014; 71:113-46. PMID: 25307215.
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    9. Yuen N, Lam TI, Wallace BK, Klug NR, Anderson SE, O'Donnell ME. Ischemic factor-induced increases in cerebral microvascular endothelial cell Na/H exchange activity and abundance: evidence for involvement of ERK1/2 MAP kinase. Am J Physiol Cell Physiol. 2014 May 15; 306(10):C931-42. PMID: 24647544.
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    10. Glaser N, Bundros A, Anderson S, Tancredi D, Lo W, Orgain M, O'Donnell M. Brain cell swelling during hypocapnia increases with hyperglycemia or ketosis. Pediatr Diabetes. 2014 Nov; 15(7):484-93. PMID: 24443981.
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    11. O'Donnell ME, Chen YJ, Lam TI, Taylor KC, Walton JH, Anderson SE. Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger. J Cereb Blood Flow Metab. 2013 Feb; 33(2):225-34. PMID: 23149557.
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    12. Glaser N, Ngo C, Anderson S, Yuen N, Trifu A, O'Donnell M. Effects of hyperglycemia and effects of ketosis on cerebral perfusion, cerebral water distribution, and cerebral metabolism. Diabetes. 2012 Jul; 61(7):1831-7. PMID: 22498698.
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    13. Glaser N, Anderson S, Leong W, Tancredi D, O'Donnell M. Cognitive dysfunction associated with diabetic ketoacidosis in rats. Neurosci Lett. 2012 Feb 29; 510(2):110-4. PMID: 22266599.
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    14. Wallace BK, Jelks KA, O'Donnell ME. Ischemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38 and JNK MAP kinases. Am J Physiol Cell Physiol. 2012 Feb 01; 302(3):C505-17. PMID: 22049209.
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    15. Chen YJ, Raman G, Bodendiek S, O'Donnell ME, Wulff H. The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke. J Cereb Blood Flow Metab. 2011 Dec; 31(12):2363-74. PMID: 21750563.
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    16. Wallace BK, Foroutan S, O'Donnell ME. Ischemia-induced stimulation of Na-K-Cl cotransport in cerebral microvascular endothelial cells involves AMP kinase. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C316-26. PMID: 21562306.
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    17. Rutkowsky JM, Wallace BK, Wise PM, O'Donnell ME. Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance. Am J Physiol Cell Physiol. 2011 Jul; 301(1):C204-12. PMID: 21471464.
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    18. Neuwelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, Janigro D, Leybaert L, Molnár Z, O'Donnell ME, Povlishock JT, Saunders NR, Sharp F, Stanimirovic D, Watts RJ, Drewes LR. Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci. 2011 Mar; 12(3):169-82. PMID: 21331083.
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    19. Glaser N, Yuen N, Anderson SE, Tancredi DJ, O'Donnell ME. Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide. Diabetes. 2010 Mar; 59(3):702-9. PMID: 20028943.
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    20. Lam TI, Wise PM, O'Donnell ME. Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin. Am J Physiol Cell Physiol. 2009 Aug; 297(2):C278-89. PMID: 19458287.
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    21. Yuen N, Anderson SE, Glaser N, Tancredi DJ, O'Donnell ME. Cerebral blood flow and cerebral edema in rats with diabetic ketoacidosis. Diabetes. 2008 Oct; 57(10):2588-94. PMID: 18633109.
      View in: PubMed
    22. Chang E, O'Donnell ME, Barakat AI. Shear stress and 17beta-estradiol modulate cerebral microvascular endothelial Na-K-Cl cotransporter and Na/H exchanger protein levels. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C363-71. PMID: 17959724.
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    23. Brillault J, Lam TI, Rutkowsky JM, Foroutan S, O'Donnell ME. Hypoxia effects on cell volume and ion uptake of cerebral microvascular endothelial cells. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C88-96. PMID: 17942640.
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    24. Pedersen SF, O'Donnell ME, Anderson SE, Cala PM. Physiology and pathophysiology of Na+/H+ exchange and Na+ -K+ -2Cl- cotransport in the heart, brain, and blood. Am J Physiol Regul Integr Comp Physiol. 2006 Jul; 291(1):R1-25. PMID: 16484438.
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    25. O'Donnell ME, Lam TI, Tran LQ, Foroutan S, Anderson SE. Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion. J Cereb Blood Flow Metab. 2006 Oct; 26(10):1234-49. PMID: 16421506.
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    26. Foroutan S, Brillault J, Forbush B, O'Donnell ME. Moderate-to-severe ischemic conditions increase activity and phosphorylation of the cerebral microvascular endothelial cell Na+-K+-Cl- cotransporter. Am J Physiol Cell Physiol. 2005 Dec; 289(6):C1492-501. PMID: 16079189.
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    27. O'Donnell ME, Duong V, Suvatne J, Foroutan S, Johnson DM. Arginine vasopressin stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransporter activity is V1 receptor and [Ca] dependent. Am J Physiol Cell Physiol. 2005 Aug; 289(2):C283-92. PMID: 15800057.
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    28. Lam TI, Anderson SE, Glaser N, O'Donnell ME. Bumetanide reduces cerebral edema formation in rats with diabetic ketoacidosis. Diabetes. 2005 Feb; 54(2):510-6. PMID: 15677509.
      View in: PubMed
    29. O'Donnell ME, Tran L, Lam TI, Liu XB, Anderson SE. Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke. J Cereb Blood Flow Metab. 2004 Sep; 24(9):1046-56. PMID: 15356425.
      View in: PubMed
    30. O'Donnell ME, Lam TI, Tran L, Anderson SE. The role of the blood-brain barrier Na-K-2Cl cotransporter in stroke. Adv Exp Med Biol. 2004; 559:67-75. PMID: 18727228.
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    31. Vibat CR, Holland MJ, Kang JJ, Putney LK, O'Donnell ME. Quantitation of Na+-K+-2Cl- cotransport splice variants in human tissues using kinetic polymerase chain reaction. Anal Biochem. 2001 Nov 15; 298(2):218-30. PMID: 11700976.
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    32. Stamer WD, Peppel K, O'Donnell ME, Roberts BC, Wu F, Epstein DL. Expression of aquaporin-1 in human trabecular meshwork cells: role in resting cell volume. Invest Ophthalmol Vis Sci. 2001 Jul; 42(8):1803-11. PMID: 11431445.
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    33. Suvatne J, Barakat AI, O'Donnell ME. Flow-induced expression of endothelial Na-K-Cl cotransport: dependence on K(+) and Cl(-) channels. Am J Physiol Cell Physiol. 2001 Jan; 280(1):C216-27. PMID: 11121393.
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    34. Brandt JD, O'Donnell ME. How does the trabecular meshwork regulate outflow? Clues from the vascular endothelium. J Glaucoma. 1999 Oct; 8(5):328-39. PMID: 10529934.
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    35. Putney LK, Vibat CR, O'Donnell ME. Intracellular Cl regulates Na-K-Cl cotransport activity in human trabecular meshwork cells. Am J Physiol. 1999 09; 277(3):C373-83. PMID: 10484324.
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    36. Al-Aswad LA, Gong H, Lee D, O'Donnell ME, Brandt JD, Ryan WJ, Schroeder A, Erickson KA. Effects of Na-K-2Cl cotransport regulators on outflow facility in calf and human eyes in vitro. Invest Ophthalmol Vis Sci. 1999 Jul; 40(8):1695-701. PMID: 10393038.
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    37. Putney LK, Brandt JD, O'Donnell ME. Na-K-Cl cotransport in normal and glaucomatous human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 1999 Feb; 40(2):425-34. PMID: 9950602.
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    38. Cai S, Pestic-Dragovich L, O'Donnell ME, Wang N, Ingber D, Elson E, De Lanerolle P. Regulation of cytoskeletal mechanics and cell growth by myosin light chain phosphorylation. Am J Physiol. 1998 11; 275(5):C1349-56. PMID: 9814984.
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    39. Kajimura M, O'Donnell ME, Curry FE. Effect of cell shrinkage on permeability of cultured bovine aortic endothelia and frog mesenteric capillaries. J Physiol. 1997 Sep 01; 503 ( Pt 2):413-25. PMID: 9306282.
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    40. Yerby TR, Vibat CR, Sun D, Payne JA, O'Donnell ME. Molecular characterization of the Na-K-Cl cotransporter of bovine aortic endothelial cells. Am J Physiol. 1997 Jul; 273(1 Pt 1):C188-97. PMID: 9252456.
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    41. Sun D, Lytle C, O'Donnell ME. IL-6 secreted by astroglial cells regulates Na-K-Cl cotransport in brain microvessel endothelial cells. Am J Physiol. 1997 Jun; 272(6 Pt 1):C1829-35. PMID: 9227411.
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    42. Putney LK, Brandt JD, O'Donnell ME. Effects of dexamethasone on sodium-potassium-chloride cotransport in trabecular meshwork cells. Invest Ophthalmol Vis Sci. 1997 May; 38(6):1229-40. PMID: 9152243.
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    43. Sun D, O'Donnell ME. Astroglial-mediated phosphorylation of the Na-K-Cl cotransporter in brain microvessel endothelial cells. Am J Physiol. 1996 Aug; 271(2 Pt 1):C620-7. PMID: 8770003.
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    44. Sun D, Lytle C, O'Donnell ME. Astroglial cell-induced expression of Na-K-Cl cotransporter in brain microvascular endothelial cells. Am J Physiol. 1995 Dec; 269(6 Pt 1):C1506-12. PMID: 8572180.
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    45. O'Donnell ME, Martinez A, Sun D. Endothelial Na-K-Cl cotransport regulation by tonicity and hormones: phosphorylation of cotransport protein. Am J Physiol. 1995 Dec; 269(6 Pt 1):C1513-23. PMID: 8572181.
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    46. O'Donnell ME, Brandt JD, Curry FR. Na-K-Cl cotransport regulates intracellular volume and monolayer permeability of trabecular meshwork cells. Am J Physiol. 1995 Apr; 268(4 Pt 1):C1067-74. PMID: 7733229.
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    47. O'Donnell ME, Martinez A, Sun D. Cerebral microvascular endothelial cell Na-K-Cl cotransport: regulation by astrocyte-conditioned medium. Am J Physiol. 1995 Mar; 268(3 Pt 1):C747-54. PMID: 7900779.
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    48. O'Donnell ME, Owen NE. Regulation of ion pumps and carriers in vascular smooth muscle. Physiol Rev. 1994 Jul; 74(3):683-721. PMID: 8036250.
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    49. Leung S, O'Donnell ME, Martinez A, Palfrey HC. Regulation by nerve growth factor and protein phosphorylation of Na/K/2Cl cotransport and cell volume in PC12 cells. J Biol Chem. 1994 Apr 08; 269(14):10581-9. PMID: 8144646.
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    50. O'Donnell ME. Role of Na-K-Cl cotransport in vascular endothelial cell volume regulation. Am J Physiol. 1993 May; 264(5 Pt 1):C1316-26. PMID: 8498488.
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    51. O'Donnell ME. Endothelial cell sodium-potassium-chloride cotransport. Evidence of regulation by Ca2+ and protein kinase C. J Biol Chem. 1991 Jun 25; 266(18):11559-66. PMID: 2050666.
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    52. O'Donnell ME, Owen NE. Sodium cotransport in vascular smooth muscle cells. Blood Vessels. 1991; 28(1-3):138-46. PMID: 1848123.
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    53. Hansen BA, Batlle DC, O'Donnell ME. Sodium-calcium exchange in bovine aortic endothelial cells. Ann N Y Acad Sci. 1991; 639:566-9. PMID: 1785885.
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    54. O'Donnell ME. [3H]bumetanide binding in vascular endothelial cells. Quantitation of Na-K-Cl cotransporters. J Biol Chem. 1989 Dec 05; 264(34):20326-30. PMID: 2555354.
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    55. O'Donnell ME. Regulation of Na-K-Cl cotransport in endothelial cells by atrial natriuretic factor. Am J Physiol. 1989 Jul; 257(1 Pt 1):C36-44. PMID: 2546434.
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    56. O'Donnell ME, Owen NE. Reduced Na-K-Cl cotransport in vascular smooth muscle cells from spontaneously hypertensive rats. Am J Physiol. 1988 Aug; 255(2 Pt 1):C169-80. PMID: 2841860.
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    57. O'Donnell ME, Bush EN, Holleman W, Owen NE. Biologically active atrial natriuretic peptides selectively activate Na/K/Cl cotransport in vascular smooth muscle cells. J Pharmacol Exp Ther. 1987 Dec; 243(3):822-8. PMID: 2826759.
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    58. Owen NE, Bush EN, Holleman W, O'Donnell ME. Effect of atrial natriuretic factor on Na+-K+-Cl- cotransport of vascular smooth muscle cells. Hypertension. 1987 Nov; 10(5 Pt 2):I128-30. PMID: 2824361.
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    59. O'Donnell ME, Owen NE. Role of cyclic GMP in atrial natriuretic factor stimulation of Na+,K+,Cl- cotransport in vascular smooth muscle cells. J Biol Chem. 1986 Nov 25; 261(33):15461-6. PMID: 2430959.
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    60. O'Donnell ME, Owen NE. Atrial natriuretic factor stimulates Na/K/Cl cotransport in vascular smooth muscle cells. Proc Natl Acad Sci U S A. 1986 Aug; 83(16):6132-6. PMID: 2942944.
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    61. Rittenhouse J, Moberly L, O'Donnell ME, Owen NE, Marcus F. Phosphorylation of atrial natriuretic peptides by cyclic AMP-dependent protein kinase. J Biol Chem. 1986 Jun 15; 261(17):7607-10. PMID: 2940244.
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    62. O'Donnell ME, Cragoe EJ, Becker JH. Inhibition of Na+ flux in Chinese hamster ovary cells and Swiss 3T3 cells by a potent new derivative of amiloride, methylisopropyl-amiloride. J Pharmacol Exp Ther. 1986 Jun; 237(3):853-61. PMID: 3012071.
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    63. O'Donnell ME, Cragoe E, Villereal ML. Inhibition of Na+ influx and DNA synthesis in human fibroblasts and neuroblastoma-glioma hybrid cells by amiloride analogs. J Pharmacol Exp Ther. 1983 Aug; 226(2):368-72. PMID: 6875850.
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    64. O'Donnell ME, Villereal ML. Membrane potential and sodium flux in neuroblastoma X glioma hybrid cells: effects of amiloride and serum. J Cell Physiol. 1982 Dec; 113(3):405-12. PMID: 7174741.
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    65. O'Donnell ME, Horwitz BA. Effects of butyrate on ouabain-sensitive respiration of hamster brown adipocytes. Am J Physiol. 1982 Jan; 242(1):C46-51. PMID: 7058878.
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