Yi-Je (Jay) Chen

Title(s)Assistant Professor, Pharmacology
SchoolSchool of Medicine
Address2225A Tupper Hall
CA 95616
Phone530-752-8648
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Exacerbated brain edema in a rat streptozotocin model of hyperglycemic ischemic stroke: Evidence for involvement of blood-brain barrier Na-K-Cl cotransport and Na/H exchange. J Cereb Blood Flow Metab. 2019 09; 39(9):1678-1692. Yuen NY, Chechneva OV, Chen YJ, Tsai YC, Little LK, Dang J, Tancredi DJ, Conston J, Anderson SE, O'Donnell ME. PMID: 29739261; PMCID: PMC6727129.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    2. Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. Ann Clin Transl Neurol. 2018 02; 5(2):147-161. Chen YJ, Nguyen HM, Maezawa I, Jin LW, Wulff H. PMID: 29468176; PMCID: PMC5817832.
      View in: PubMed   Mentions: 24     Fields:    
    3. Chapter 7 Blood-Brain Barrier Mechanisms of Edema Formation The Role of Ion Transporters and Channels. . 2017 Jan 1; 129-149. O’Donnell OM, Wulff WH, Chen CY. .
      View in: Publisher Site   Mentions:
    4. Multimodal second harmonic generation and two photon fluorescence imaging of microdomain calcium contraction coupling in single cardiomyocytes. Proceedings of SPIE. 2016 Nov 24; 10013:1001304-1001304-7. Chan CJ, Awasthi AS, Izu IL, Mao MZ, Jian JZ, Landas LT, Lerner LA, Shimkunas SR, Woldeyesus WR, Bossuyt BJ, Wood WB, Chen CY, Matthews MD, Lieu LD, Chiamvimonvat CN, Lam LK, Chen-Izu CY. .
      View in: Publisher Site   Mentions:
    5. In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. PLoS One. 2016; 11(8):e0160605. Jian Z, Chen YJ, Shimkunas R, Jian Y, Jaradeh M, Chavez K, Chiamvimonvat N, Tardiff JC, Izu LT, Ross RS, Chen-Izu Y. PMID: 27500929; PMCID: PMC4976940.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes. Circ Res. 2016 01 22; 118(2):e19-28. Awasthi S, Izu LT, Mao Z, Jian Z, Landas T, Lerner A, Shimkunas R, Woldeyesus R, Bossuyt J, Wood BM, Chen YJ, Matthews DL, Lieu DK, Chiamvimonvat N, Lam KS, Chen-Izu Y, Chan JW. PMID: 26643875; PMCID: PMC4740258.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    7. The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke. J Cereb Blood Flow Metab. 2016 12; 36(12):2146-2161. Chen YJ, Nguyen HM, Maezawa I, Grössinger EM, Garing AL, Köhler R, Jin LW, Wulff H. PMID: 26661208; PMCID: PMC5363659.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    8. The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant. Neurotherapeutics. 2015 Jan; 12(1):234-49. Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H. PMID: 25256961; PMCID: PMC4322077.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    9. Blood-brain barrier KCa3.1 channels: evidence for a role in brain Na uptake and edema in ischemic stroke. Stroke. 2015 Jan; 46(1):237-44. Chen YJ, Wallace BK, Yuen N, Jenkins DP, Wulff H, O'Donnell ME. PMID: 25477223; PMCID: PMC4276511.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    10. Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis--xenograft model. J Autoimmun. 2014 Dec; 55:63-72. Kundu-Raychaudhuri S, Chen YJ, Wulff H, Raychaudhuri SP. PMID: 25175978; PMCID: PMC4398058.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    11. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Sci Signal. 2014 Mar 18; 7(317):ra27. Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, Banyasz T, Tardiff JC, Chiamvimonvat N, Bers DM, Lam KS, Chen-Izu Y. PMID: 24643800; PMCID: PMC4103414.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    12. The Ca²⁺-activated K⁺ channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy. PLoS One. 2013; 8(11):e81006. Chen YJ, Lam J, Gregory CR, Schrepfer S, Wulff H. PMID: 24312257; PMCID: PMC3843675.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    13. The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease. Transplantation. 2013 Jan 27; 95(2):285-92. Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Köhler R, Miura H, Länger F, Reichenspurner H, Robbins RC, Schrepfer S. PMID: 23325003; PMCID: PMC3777777.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    14. NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Br J Pharmacol. 2013 Jan; 168(2):432-44. Strøbæk D, Brown DT, Jenkins DP, Chen YJ, Coleman N, Ando Y, Chiu P, Jørgensen S, Demnitz J, Wulff H, Christophersen P. PMID: 22891655; PMCID: PMC3572569.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    15. Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger. J Cereb Blood Flow Metab. 2013 Feb; 33(2):225-34. O'Donnell ME, Chen YJ, Lam TI, Taylor KC, Walton JH, Anderson SE. PMID: 23149557; PMCID: PMC3564192.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    16. The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke. J Cereb Blood Flow Metab. 2011 Dec; 31(12):2363-74. Chen YJ, Raman G, Bodendiek S, O'Donnell ME, Wulff H. PMID: 21750563; PMCID: PMC3323185.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    17. Pharmacokinetics and pharmacodynamics of A77 1726 and leflunomide in domestic cats. J Vet Pharmacol Ther. 2012 Apr; 35(2):139-46. Mehl ML, Tell L, Kyles AE, Chen YJ, Craigmill A, Gregory CR. PMID: 21615755.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCTClinical Trials
    18. In vitro effects of the active metabolite of leflunomide, A77 1726, on feline herpesvirus-1. Am J Vet Res. 2007 Sep; 68(9):1010-5. Williams CR, Sykes JE, Mehl M, MacLeod JS, Lindsay LL, Poland AM, Chen YJ, Kyles AE, Waldman WJ, Gregory CR. PMID: 17764417.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. Oral pharmacokinetic and pharmacodynamic effects of FTY720 in cats. J Vet Pharmacol Ther. 2007 Feb; 30(1):55-61. Downes S, Chen YJ, Kyles A, Gregory C. PMID: 17217402.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCellsCTClinical Trials
    20. In vitro evaluation of the effect of a novel immunosuppressive agent, FTY720, on the function of feline neutrophils. Am J Vet Res. 2006 Apr; 67(4):588-92. Chen YJ, Kyles AE, Gregory CR. PMID: 16579750.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
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