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Yi-Je Chen

Title(s)Assistant Professor, Pharmacology
SchoolUniversity of California, Davis
Phone530-752-8648
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yuen NY, Chechneva OV, Chen YJ, Tsai YC, Little LK, Dang J, Tancredi DJ, Conston J, Anderson SE, O'Donnell ME. Exacerbated brain edema in a rat streptozotocin model of hyperglycemic ischemic stroke: Evidence for involvement of blood-brain barrier Na-K-Cl cotransport and Na/H exchange. J Cereb Blood Flow Metab. 2019 Sep; 39(9):1678-1692. PMID: 29739261.
      View in: PubMed
    2. Jian Z, Chen YJ, Shimkunas R, Jian Y, Jaradeh M, Chavez K, Chiamvimonvat N, Tardiff JC, Izu LT, Ross RS, Chen-Izu Y. In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. PLoS One. 2016; 11(8):e0160605. PMID: 27500929.
      View in: PubMed
    3. Awasthi S, Izu LT, Mao Z, Jian Z, Landas T, Lerner A, Shimkunas R, Woldeyesus R, Bossuyt J, Wood BM, Chen YJ, Matthews DL, Lieu DK, Chiamvimonvat N, Lam KS, Chen-Izu Y, Chan JW. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes. Circ Res. 2016 01 22; 118(2):e19-28. PMID: 26643875.
      View in: PubMed
    4. Chen YJ, Nguyen HM, Maezawa I, Grössinger EM, Garing AL, Köhler R, Jin LW, Wulff H. The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke. J Cereb Blood Flow Metab. 2016 12; 36(12):2146-2161. PMID: 26661208.
      View in: PubMed
    5. Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H. The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant. Neurotherapeutics. 2015 Jan; 12(1):234-49. PMID: 25256961.
      View in: PubMed
    6. Chen YJ, Wallace BK, Yuen N, Jenkins DP, Wulff H, O'Donnell ME. Blood-brain barrier KCa3.1 channels: evidence for a role in brain Na uptake and edema in ischemic stroke. Stroke. 2015 Jan; 46(1):237-44. PMID: 25477223.
      View in: PubMed
    7. Kundu-Raychaudhuri S, Chen YJ, Wulff H, Raychaudhuri SP. Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis--xenograft model. J Autoimmun. 2014 Dec; 55:63-72. PMID: 25175978.
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    8. Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, Banyasz T, Tardiff JC, Chiamvimonvat N, Bers DM, Lam KS, Chen-Izu Y. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Sci Signal. 2014 Mar 18; 7(317):ra27. PMID: 24643800.
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    9. Chen YJ, Lam J, Gregory CR, Schrepfer S, Wulff H. The Ca²?-activated K? channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy. PLoS One. 2013; 8(11):e81006. PMID: 24312257.
      View in: PubMed
    10. Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Köhler R, Miura H, Länger F, Reichenspurner H, Robbins RC, Schrepfer S. The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease. Transplantation. 2013 Jan 27; 95(2):285-92. PMID: 23325003.
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    11. Strøbæk D, Brown DT, Jenkins DP, Chen YJ, Coleman N, Ando Y, Chiu P, Jørgensen S, Demnitz J, Wulff H, Christophersen P. NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Br J Pharmacol. 2013 Jan; 168(2):432-44. PMID: 22891655.
      View in: PubMed
    12. O'Donnell ME, Chen YJ, Lam TI, Taylor KC, Walton JH, Anderson SE. Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger. J Cereb Blood Flow Metab. 2013 Feb; 33(2):225-34. PMID: 23149557.
      View in: PubMed
    13. Chen YJ, Raman G, Bodendiek S, O'Donnell ME, Wulff H. The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke. J Cereb Blood Flow Metab. 2011 Dec; 31(12):2363-74. PMID: 21750563.
      View in: PubMed
    14. Mehl ML, Tell L, Kyles AE, Chen YJ, Craigmill A, Gregory CR. Pharmacokinetics and pharmacodynamics of A77 1726 and leflunomide in domestic cats. J Vet Pharmacol Ther. 2012 Apr; 35(2):139-46. PMID: 21615755.
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    15. Williams CR, Sykes JE, Mehl M, MacLeod JS, Lindsay LL, Poland AM, Chen YJ, Kyles AE, Waldman WJ, Gregory CR. In vitro effects of the active metabolite of leflunomide, A77 1726, on feline herpesvirus-1. Am J Vet Res. 2007 Sep; 68(9):1010-5. PMID: 17764417.
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    16. Downes S, Chen YJ, Kyles A, Gregory C. Oral pharmacokinetic and pharmacodynamic effects of FTY720 in cats. J Vet Pharmacol Ther. 2007 Feb; 30(1):55-61. PMID: 17217402.
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    17. Chen YJ, Kyles AE, Gregory CR. In vitro evaluation of the effect of a novel immunosuppressive agent, FTY720, on the function of feline neutrophils. Am J Vet Res. 2006 Apr; 67(4):588-92. PMID: 16579750.
      View in: PubMed