Deborah K. Lieu

Title(s)Assistant Professor, Cardiovascular Medicine
SchoolSchool of Medicine
AddressInstitute for Regenerative Cures 1616
CA 95817
Phone916-734-0683
vCardDownload vCard

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The sinoatrial node extracellular matrix promotes pacemaker phenotype and protects automaticity in engineered heart tissues from cyclic strain. Cell Rep. 2023 12 26; 42(12):113505. Sun YH, Kao HKJ, Thai PN, Smithers R, Chang CW, Pretto D, Yechikov S, Oppenheimer S, Bedolla A, Chalker BA, Ghobashy R, Nolta JA, Chan JW, Chiamvimonvat N, Lieu DK. PMID: 38041810; PMCID: PMC10790625.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues. iScience. 2023 Apr 21; 26(4):106302. Cheng S, Brenière-Letuffe D, Ahola V, Wong AOT, Keung HY, Gurung B, Zheng Z, Costa KD, Lieu DK, Keung W, Li RA. PMID: 36950112; PMCID: PMC10025988.
      View in: PubMed   Mentions: 1  
    3. Making Heads or Tails of the Large Mammalian Sinoatrial Node Micro-Organization. Circ Arrhythm Electrophysiol. 2021 12; 14(12):e010465. Smithers RL, Kao HKJ, Zeigler S, Yechikov S, Nolta JA, Chan JW, Chiamvimonvat N, Lieu DK. PMID: 34794338; PMCID: PMC8692394.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Model Systems for Addressing Mechanism of Arrhythmogenesis in Cardiac Repair. Curr Cardiol Rep. 2021 05 29; 23(6):72. Zhang XD, Thai PN, Lieu DK, Chiamvimonvat N. PMID: 34050853; PMCID: PMC8164614.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Cardiac small-conductance calcium-activated potassium channels in health and disease. Pflugers Arch. 2021 03; 473(3):477-489. Zhang XD, Thai PN, Lieu DK, Chiamvimonvat N. PMID: 33624131; PMCID: PMC7940285.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    6. Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues. J Mol Cell Cardiol. 2021 04; 153:106-110. Wong AO, Gurung B, Wong WS, Mak SY, Tse WW, Li CM, Lieu DK, Costa KD, Li RA, Hajjar RJ. PMID: 33373642; PMCID: PMC7765761.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    7. NODAL inhibition promotes differentiation of pacemaker-like cardiomyocytes from human induced pluripotent stem cells. Stem Cell Res. 2020 12; 49:102043. Yechikov S, Kao HKJ, Chang CW, Pretto D, Zhang XD, Sun YH, Smithers R, Sirish P, Nolta JA, Chan JW, Chiamvimonvat N, Lieu DK. PMID: 33128951; PMCID: PMC7814970.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    8. Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy. Stem Cells Transl Med. 2020 12; 9(12):1570-1584. Sirish P, Thai PN, Lee JH, Yang J, Zhang XD, Ren L, Li N, Timofeyev V, Lee KSS, Nader CE, Rowland DJ, Yechikov S, Ganaga S, Young N, Lieu DK, Yamoah EN, Hammock BD, Chiamvimonvat N. PMID: 32790136; PMCID: PMC7695637.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    9. An intrinsic, label-free signal for identifying stem cell-derived cardiomyocyte subtype. Stem Cells. 2020 03; 38(3):390-394. Chang CW, Kao HKJ, Yechikov S, Lieu DK, Chan JW. PMID: 31778240; PMCID: PMC7302059.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Human induced pluripotent stem cell line with genetically encoded fluorescent voltage indicator generated via CRISPR for action potential assessment post-cardiogenesis. Stem Cells. 2020 01; 38(1):90-101. Sun YH, Kao HKJ, Chang CW, Merleev A, Overton JL, Pretto D, Yechikov S, Maverakis E, Chiamvimonvat N, Chan JW, Lieu DK. PMID: 31566285; PMCID: PMC7304550.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    11. Correlation between frataxin expression and contractility revealed by in vitro Friedreich's ataxia cardiac tissue models engineered from human pluripotent stem cells. Stem Cell Res Ther. 2019 07 08; 10(1):203. Wong AO, Wong G, Shen M, Chow MZ, Tse WW, Gurung B, Mak SY, Lieu DK, Costa KD, Chan CW, Martelli A, Nabhan JF, Li RA. PMID: 31286988; PMCID: PMC6615274.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    12. Cardiac applications of second harmonic generation (SHG) microscopy. . 2019 Feb 22; 10882:1088213-1088213-7. Chang CC, Ledford LH, Kao KH, Zhang ZX, Chiamvimonvat CN, Lieu LD, Chan CJ. .
      View in: Publisher Site   Mentions:
    13. Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles. Int J Nanomedicine. 2018; 13:6073-6078. Yamoah MA, Moshref M, Sharma J, Chen WC, Ledford HA, Lee JH, Chavez KS, Wang W, López JE, Lieu DK, Sirish P, Zhang XD. PMID: 30323594; PMCID: PMC6179720.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    14. Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix. PLoS One. 2017; 12(9):e0185125. Gluck JM, Herren AW, Yechikov S, Kao HKJ, Khan A, Phinney BS, Chiamvimonvat N, Chan JW, Lieu DK. PMID: 28934329; PMCID: PMC5608342.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    15. Multimodal second harmonic generation and two photon fluorescence imaging of microdomain calcium contraction coupling in single cardiomyocytes. Proceedings of SPIE. 2016 Nov 24; 10013:1001304-1001304-7. Chan CJ, Awasthi AS, Izu IL, Mao MZ, Jian JZ, Landas LT, Lerner LA, Shimkunas SR, Woldeyesus WR, Bossuyt BJ, Wood WB, Chen CY, Matthews MD, Lieu LD, Chiamvimonvat CN, Lam LK, Chen-Izu CY. .
      View in: Publisher Site   Mentions:
    16. Same-Single-Cell Analysis of Pacemaker-Specific Markers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Subtypes Classified by Electrophysiology. Stem Cells. 2016 11; 34(11):2670-2680. Yechikov S, Copaciu R, Gluck JM, Deng W, Chiamvimonvat N, Chan JW, Lieu DK. PMID: 27434649; PMCID: PMC5798452.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    17. Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2016 May; 9(5). Sirish P, Li N, Timofeyev V, Zhang XD, Wang L, Yang J, Lee KS, Bettaieb A, Ma SM, Lee JH, Su D, Lau VC, Myers RE, Lieu DK, López JE, Young JN, Yamoah EN, Haj F, Ripplinger CM, Hammock BD, Chiamvimonvat N. PMID: 27162031; PMCID: PMC4869994.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    18. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes. Circ Res. 2016 01 22; 118(2):e19-28. Awasthi S, Izu LT, Mao Z, Jian Z, Landas T, Lerner A, Shimkunas R, Woldeyesus R, Bossuyt J, Wood BM, Chen YJ, Matthews DL, Lieu DK, Chiamvimonvat N, Lam KS, Chen-Izu Y, Chan JW. PMID: 26643875; PMCID: PMC4740258.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    19. Non-linear optical flow cytometry using a scanned, Bessel beam light-sheet. Sci Rep. 2015 May 29; 5:10751. Collier BB, Awasthi S, Lieu DK, Chan JW. PMID: 26021750; PMCID: PMC4448227.
      View in: PubMed   Mentions: 4     Fields:    
    20. Small-conductance Ca2+ -activated K+ channels and cardiac arrhythmias. Heart Rhythm. 2015 Aug; 12(8):1845-51. Zhang XD, Lieu DK, Chiamvimonvat N. PMID: 25956967; PMCID: PMC4662728.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    21. Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation. Circ Cardiovasc Genet. 2015 Jun; 8(3):427-36. Poon E, Keung W, Liang Y, Ramalingam R, Yan B, Zhang S, Chopra A, Moore J, Herren A, Lieu DK, Wong HS, Weng Z, Wong OT, Lam YW, Tomaselli GF, Chen C, Boheler KR, Li RA. PMID: 25759434.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    22. Non-linear optical measurements using a scanned, Bessel beam. Proceedings of SPIE. 2015 Mar 2; 9328:932815-932815-6. Collier CB, Awasthi AS, Lieu LD, Chan CJ. .
      View in: Publisher Site   Mentions:
    23. Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes. Stem Cells Transl Med. 2014 Jan; 3(1):18-31. Karakikes I, Senyei GD, Hansen J, Kong CW, Azeloglu EU, Stillitano F, Lieu DK, Wang J, Ren L, Hulot JS, Iyengar R, Li RA, Hajjar RJ. PMID: 24324277; PMCID: PMC3902291.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    24. Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes. Cardiovasc Res. 2014 Feb 01; 101(2):317-25. Zhang XD, Timofeyev V, Li N, Myers RE, Zhang DM, Singapuri A, Lau VC, Bond CT, Adelman J, Lieu DK, Chiamvimonvat N. PMID: 24282291; PMCID: PMC3896251.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    25. Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes crucial for maturation. PLoS One. 2013; 8(10):e77784. Poon E, Yan B, Zhang S, Rushing S, Keung W, Ren L, Lieu DK, Geng L, Kong CW, Wang J, Wong HS, Boheler KR, Li RA. PMID: 24204964; PMCID: PMC3804624.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    26. Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias. Biomaterials. 2013 Nov; 34(35):8878-86. Wang J, Chen A, Lieu DK, Karakikes I, Chen G, Keung W, Chan CW, Hajjar RJ, Costa KD, Khine M, Li RA. PMID: 23942210.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    27. Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes. Circ Arrhythm Electrophysiol. 2013 Feb; 6(1):191-201. Lieu DK, Fu JD, Chiamvimonvat N, Tung KC, McNerney GP, Huser T, Keller G, Kong CW, Li RA. PMID: 23392582; PMCID: PMC3757253.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    28. Cardiac tissue engineering using human stem cell-derived cardiomyocytes for disease modeling and drug discovery. Drug Discov Today Dis Models. 2012; 9(4):e219-e227. Turnbull IC, Lieu DK, Li RA, Costa KD. PMID: 33968153; PMCID: PMC8104361.
      View in: PubMed   Mentions: 4  
    29. Induced pluripotent stem cells as a disease model for studying inherited arrhythmias: promises and hurdles. Drug Discovery Today Disease Models. 2012 Dec 1; 9(4):e199-e207. Lui LK, Stachel SM, Lieu LD, Li LR, Bu BL. .
      View in: Publisher Site   Mentions:
    30. Engineered human pluripotent stem cell-derived cardiac cells and tissues for electrophysiological studies. Drug Discov Today Dis Models. 2012; 9(4):e209-e217. Lieu DK, Turnbull IC, Costa KD, Li RA. PMID: 29422934; PMCID: PMC5800742.
      View in: PubMed   Mentions: 7  
    31. Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes. PLoS One. 2011; 6(11):e27417. Fu JD, Rushing SN, Lieu DK, Chan CW, Kong CW, Geng L, Wilson KD, Chiamvimonvat N, Boheler KR, Wu JC, Keller G, Hajjar RJ, Li RA. PMID: 22110643; PMCID: PMC3217986.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    32. Label-free identification and characterization of human pluripotent stem cell-derived cardiomyocytes using second harmonic generation (SHG) microscopy. J Biophotonics. 2012 Jan; 5(1):57-66. Awasthi S, Matthews DL, Li RA, Chiamvimonvat N, Lieu DK, Chan JW. PMID: 22083829; PMCID: PMC3817927.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    33. Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives. Adv Mater. 2011 Dec 22; 23(48):5785-91. Chen A, Lieu DK, Freschauf L, Lew V, Sharma H, Wang J, Nguyen D, Karakikes I, Hajjar RJ, Gopinathan A, Botvinick E, Fowlkes CC, Li RA, Khine M. PMID: 22065428.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    34. Multiscale biomimetic topography for the alignment of neonatal and embryonic stem cell-derived heart cells. Tissue Eng Part C Methods. 2011 May; 17(5):579-88. Luna JI, Ciriza J, Garcia-Ojeda ME, Kong M, Herren A, Lieu DK, Li RA, Fowlkes CC, Khine M, McCloskey KE. PMID: 21235325.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    35. Manipulations of microRNA in human pluripotent stem cells and their derivatives. Methods Mol Biol. 2011; 690:107-20. Rushing SN, Herren AW, Lieu DK, Li RA. PMID: 21042988.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    36. Ouabain facilitates cardiac differentiation of mouse embryonic stem cells through ERK1/2 pathway. Acta Pharmacol Sin. 2011 Jan; 32(1):52-61. Lee YK, Ng KM, Lai WH, Man C, Lieu DK, Lau CP, Tse HF, Siu CW. PMID: 21151160; PMCID: PMC4003319.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    37. Electrophysiological properties of human induced pluripotent stem cells. Am J Physiol Cell Physiol. 2010 Mar; 298(3):C486-95. Jiang P, Rushing SN, Kong CW, Fu J, Lieu DK, Chan CW, Deng W, Li RA. PMID: 19955484; PMCID: PMC2838581.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    38. Absence of transverse tubules contributes to non-uniform Ca(2+) wavefronts in mouse and human embryonic stem cell-derived cardiomyocytes. Stem Cells Dev. 2009 Dec; 18(10):1493-500. Lieu DK, Liu J, Siu CW, McNerney GP, Tse HF, Abu-Khalil A, Huser T, Li RA. PMID: 19290776; PMCID: PMC3139544.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    39. Label-free biochemical characterization of stem cells using vibrational spectroscopy. J Biophotonics. 2009 Nov; 2(11):656-68. Chan JW, Lieu DK. PMID: 19653219.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    40. Facilitated maturation of Ca2+ handling properties of human embryonic stem cell-derived cardiomyocytes by calsequestrin expression. Am J Physiol Cell Physiol. 2009 Jul; 297(1):C152-9. Liu J, Lieu DK, Siu CW, Fu JD, Tse HF, Li RA. PMID: 19357236; PMCID: PMC2711646.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    41. Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopy. Anal Chem. 2009 Feb 15; 81(4):1324-31. Chan JW, Lieu DK, Huser T, Li RA. PMID: 19152312; PMCID: PMC2652839.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    42. Overexpression of HCN-encoded pacemaker current silences bioartificial pacemakers. Heart Rhythm. 2008 Sep; 5(9):1310-7. Lieu DK, Chan YC, Lau CP, Tse HF, Siu CW, Li RA. PMID: 18693074.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    43. Label-retaining cells of the bladder: candidate urothelial stem cells. Am J Physiol Renal Physiol. 2008 Jun; 294(6):F1415-21. Kurzrock EA, Lieu DK, Degraffenried LA, Chan CW, Isseroff RR. PMID: 18367656.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    44. HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering. J Membr Biol. 2006; 214(3):115-22. Siu CW, Lieu DK, Li RA. PMID: 17558529.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    45. Urothelial progenitor cells: regional differences in the rat bladder. Cell Prolif. 2007 Apr; 40(2):157-65. Nguyen MM, Lieu DK, deGraffenried LA, Isseroff RR, Kurzrock EA. PMID: 17472724; PMCID: PMC6496490.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    46. Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation. 2007 Apr 10; 115(14):1839-50. Xue T, Siu CW, Lieu DK, Lau CP, Tse HF, Li RA. PMID: 17389267; PMCID: PMC2698014.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    47. Beta1 integrin expression pattern in transitional urothelium does not allow for efficient stem cell enrichment as in other epithelia. Tissue Eng. 2007 Feb; 13(2):263-70. Lieu DK, Degraffenried LA, Isseroff RR, Kurzrock EA. PMID: 17518562.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    48. Ion Channels in Shear Stress Sensing in Vascular Endothelium. . 2007 Jan 1; 155-170. Barakat BA, Lieu LD, Gojova GA. .
      View in: Publisher Site   Mentions:
    49. Secrets of the code: do vascular endothelial cells use ion channels to decipher complex flow signals? Biomaterials. 2006 Feb; 27(5):671-8. Barakat AI, Lieu DK, Gojova A. PMID: 16112724.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    50. Rat urothelium: improved techniques for serial cultivation, expansion, freezing and reconstitution onto acellular matrix. J Urol. 2005 Jan; 173(1):281-5. Kurzrock EA, Lieu DK, deGraffenried LA, Isseroff RR. PMID: 15592097.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    51. Differential membrane potential and ion current responses to different types of shear stress in vascular endothelial cells. Am J Physiol Cell Physiol. 2004 Jun; 286(6):C1367-75. Lieu DK, Pappone PA, Barakat AI. PMID: 14761889.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    52. Differential responsiveness of vascular endothelial cells to different types of fluid mechanical shear stress. Cell Biochem Biophys. 2003; 38(3):323-43. Barakat A, Lieu D. PMID: 12794271.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    53. Microchannel Platform for the Study of Endothelial Cell Shape and Function. Biomedical Microdevices. 2002 Mar 1; 4(1):9-16. Gray GB, Lieu LD, Collins CS, Smith SR, Barakat BA. .
      View in: Publisher Site   Mentions:
    54. Stent-Induced Arterial Flow Disturbance: Whole Vessel and Cellular Considerations. . 2002 Jan 1; 287-288. Schachter SL, Lieu LD, Barakat BA. .
      View in: Publisher Site   Mentions:
    With one click, see people who:

    Mentor

    Offer Student Projects

    Run Clinical Trials

    See more options in the Advanced Search tab

    Deborah's Networks
    Concepts (255)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (20)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UC Davis Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).
    This site is running Profiles RNS version UCSF-v3.1.0-3-g1ef1264b on PROFILES-PWEB04. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California