Deborah Lieu

Title(s)Assistant Professor, Cardiovascular Medicine
SchoolUniversity of California, Davis
AddressInstitute for Regenerative Cures 1616
CA 95817
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    1. Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy. Stem Cells Transl Med. 2020 Aug 13. Sirish P, Thai PN, Lee JH, Yang J, Zhang XD, Ren L, Li N, Timofeyev V, Lee KSS, Nader CE, Rowland DJ, Yechikov S, Ganaga S, Young N, Lieu DK, Yamoah EN, Hammock BD, Chiamvimonvat N. PMID: 32790136.
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    2. An intrinsic, label-free signal for identifying stem cell-derived cardiomyocyte subtype. Stem Cells. 2020 03; 38(3):390-394. Chang CW, Kao HKJ, Yechikov S, Lieu DK, Chan JW. PMID: 31778240.
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    3. Modeling cardiac dysfunction of Friedreich's ataxia using ventricular sheets, tissues and chambers engineered from human pluripotent stem cells. J Pharmacol Toxicol Methods. 2019 Sep - Oct; 99:106595. Wong AO, Lieu DK, Wong GK, Gurung B, Tse WW, Costa KD, Chan CW, Nabhan JD, Li RA. PMID: 31962923.
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    4. Human induced pluripotent stem cell line with genetically encoded fluorescent voltage indicator generated via CRISPR for action potential assessment post-cardiogenesis. Stem Cells. 2020 01; 38(1):90-101. Sun YH, Kao HKJ, Chang CW, Merleev A, Overton JL, Pretto D, Yechikov S, Maverakis E, Chiamvimonvat N, Chan JW, Lieu DK. PMID: 31566285.
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    5. Correlation between frataxin expression and contractility revealed by in vitro Friedreich's ataxia cardiac tissue models engineered from human pluripotent stem cells. Stem Cell Res Ther. 2019 07 08; 10(1):203. Wong AO, Wong G, Shen M, Chow MZ, Tse WW, Gurung B, Mak SY, Lieu DK, Costa KD, Chan CW, Martelli A, Nabhan JF, Li RA. PMID: 31286988.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Cardiac applications of second harmonic generation (SHG) microscopy. . 2019 Feb 22; 10882:1088213-1088213-7. Che-Wei Chang, Hannah A. Ledford, Hillary K. J. Kao, Xiao-Dong Zhang, Nipavan Chiamvimonvat, Deborah K. Lieu, James W. Chan. .
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    7. Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles. Int J Nanomedicine. 2018; 13:6073-6078. Yamoah MA, Moshref M, Sharma J, Chen WC, Ledford HA, Lee JH, Chavez KS, Wang W, López JE, Lieu DK, Sirish P, Zhang XD. PMID: 30323594.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix. PLoS One. 2017; 12(9):e0185125. Gluck JM, Herren AW, Yechikov S, Kao HKJ, Khan A, Phinney BS, Chiamvimonvat N, Chan JW, Lieu DK. PMID: 28934329.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. Multimodal second harmonic generation and two photon fluorescence imaging of microdomain calcium contraction coupling in single cardiomyocytes. Proceedings of SPIE. 2016 Nov 24; 10013:1001304-1001304-7. James W. Chan, Samir Awasthi, Leighton Izu, Ziliang Mao, Zhong Jian, Trevor Landas, Aaron Lerner, Rafael Shimkunas, Rahwa Woldeyesus, Julie Bossuyt, Brittani Wood, Yi-Je Chen, Dennis L. Matthews, Deborah K. Lieu, Nipavan Chiamvimonvat, Kit S. Lam, Ye Chen-Izu. .
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    10. Same-Single-Cell Analysis of Pacemaker-Specific Markers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Subtypes Classified by Electrophysiology. Stem Cells. 2016 11; 34(11):2670-2680. Yechikov S, Copaciu R, Gluck JM, Deng W, Chiamvimonvat N, Chan JW, Lieu DK. PMID: 27434649.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2016 May; 9(5). Sirish P, Li N, Timofeyev V, Zhang XD, Wang L, Yang J, Lee KS, Bettaieb A, Ma SM, Lee JH, Su D, Lau VC, Myers RE, Lieu DK, López JE, Young JN, Yamoah EN, Haj F, Ripplinger CM, Hammock BD, Chiamvimonvat N. PMID: 27162031.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    12. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes. Circ Res. 2016 01 22; 118(2):e19-28. Awasthi S, Izu LT, Mao Z, Jian Z, Landas T, Lerner A, Shimkunas R, Woldeyesus R, Bossuyt J, Wood BM, Chen YJ, Matthews DL, Lieu DK, Chiamvimonvat N, Lam KS, Chen-Izu Y, Chan JW. PMID: 26643875.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Non-linear optical flow cytometry using a scanned, Bessel beam light-sheet. Sci Rep. 2015 May 29; 5:10751. Collier BB, Awasthi S, Lieu DK, Chan JW. PMID: 26021750.
      View in: PubMed   Mentions: 2     Fields:    
    14. Small-conductance Ca2+ -activated K+ channels and cardiac arrhythmias. Heart Rhythm. 2015 Aug; 12(8):1845-51. Zhang XD, Lieu DK, Chiamvimonvat N. PMID: 25956967.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    15. Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation. Circ Cardiovasc Genet. 2015 Jun; 8(3):427-36. Poon E, Keung W, Liang Y, Ramalingam R, Yan B, Zhang S, Chopra A, Moore J, Herren A, Lieu DK, Wong HS, Weng Z, Wong OT, Lam YW, Tomaselli GF, Chen C, Boheler KR, Li RA. PMID: 25759434.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    16. Non-linear optical measurements using a scanned, Bessel beam. Proceedings of SPIE. 2015 Mar 2; 9328:932815-932815-6. Bradley B. Collier, Samir Awasthi, Deborah K. Lieu, James W. Chan. .
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    17. Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes. Stem Cells Transl Med. 2014 Jan; 3(1):18-31. Karakikes I, Senyei GD, Hansen J, Kong CW, Azeloglu EU, Stillitano F, Lieu DK, Wang J, Ren L, Hulot JS, Iyengar R, Li RA, Hajjar RJ. PMID: 24324277.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    18. Critical roles of a small conductance Ca²?-activated K? channel (SK3) in the repolarization process of atrial myocytes. Cardiovasc Res. 2014 Feb 01; 101(2):317-25. Zhang XD, Timofeyev V, Li N, Myers RE, Zhang DM, Singapuri A, Lau VC, Bond CT, Adelman J, Lieu DK, Chiamvimonvat N. PMID: 24282291.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    19. Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes crucial for maturation. PLoS One. 2013; 8(10):e77784. Poon E, Yan B, Zhang S, Rushing S, Keung W, Ren L, Lieu DK, Geng L, Kong CW, Wang J, Wong HS, Boheler KR, Li RA. PMID: 24204964.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    20. Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias. Biomaterials. 2013 Nov; 34(35):8878-86. Wang J, Chen A, Lieu DK, Karakikes I, Chen G, Keung W, Chan CW, Hajjar RJ, Costa KD, Khine M, Li RA. PMID: 23942210.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    21. Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes. Circ Arrhythm Electrophysiol. 2013 Feb; 6(1):191-201. Lieu DK, Fu JD, Chiamvimonvat N, Tung KC, McNerney GP, Huser T, Keller G, Kong CW, Li RA. PMID: 23392582.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    22. Induced pluripotent stem cells as a disease model for studying inherited arrhythmias: promises and hurdles. Drug Discovery Today Disease Models. 2012 Dec 1; 9(4):e199-e207. Kathy O. Lui, Maxine W. Stachel, Deborah K. Lieu, Ronald A. Li, Lei Bu. .
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    23. Cardiac tissue engineering using human stem cell-derived cardiomyocytes for disease modeling and drug discovery. Drug Discovery Today Disease Models. 2012 Dec 1; 9(4):e219-e227. Irene C. Turnbull, Deborah K. Lieu, Ronald A. Li, Kevin D. Costa. .
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    24. Engineered human pluripotent stem cell-derived cardiac cells and tissues for electrophysiological studies. Drug Discov Today Dis Models. 2012; 9(4):e209-e217. Lieu DK, Turnbull IC, Costa KD, Li RA. PMID: 29422934.
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    25. Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes. PLoS One. 2011; 6(11):e27417. Fu JD, Rushing SN, Lieu DK, Chan CW, Kong CW, Geng L, Wilson KD, Chiamvimonvat N, Boheler KR, Wu JC, Keller G, Hajjar RJ, Li RA. PMID: 22110643.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    26. Label-free identification and characterization of human pluripotent stem cell-derived cardiomyocytes using second harmonic generation (SHG) microscopy. J Biophotonics. 2012 Jan; 5(1):57-66. Awasthi S, Matthews DL, Li RA, Chiamvimonvat N, Lieu DK, Chan JW. PMID: 22083829.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    27. Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives. . 2011 Dec 22; 23(48):5785-91. Chen A, Lieu DK, Freschauf L, Lew V, Sharma H, Wang J, Nguyen D, Karakikes I, Hajjar RJ, Gopinathan A, Botvinick E, Fowlkes CC, Li RA, Khine M. PMID: 22065428.
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    28. Multiscale biomimetic topography for the alignment of neonatal and embryonic stem cell-derived heart cells. Tissue Eng Part C Methods. 2011 May; 17(5):579-88. Luna JI, Ciriza J, Garcia-Ojeda ME, Kong M, Herren A, Lieu DK, Li RA, Fowlkes CC, Khine M, McCloskey KE. PMID: 21235325.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    29. Manipulations of microRNA in human pluripotent stem cells and their derivatives. Methods Mol Biol. 2011; 690:107-20. Rushing SN, Herren AW, Lieu DK, Li RA. PMID: 21042988.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    30. Ouabain facilitates cardiac differentiation of mouse embryonic stem cells through ERK1/2 pathway. Acta Pharmacol Sin. 2011 Jan; 32(1):52-61. Lee YK, Ng KM, Lai WH, Man C, Lieu DK, Lau CP, Tse HF, Siu CW. PMID: 21151160.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    31. Electrophysiological properties of human induced pluripotent stem cells. . 2010 Mar; 298(3):C486-95. Jiang P, Rushing SN, Kong CW, Fu J, Lieu DK, Chan CW, Deng W, Li RA. PMID: 19955484.
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    32. Absence of transverse tubules contributes to non-uniform Ca(2+) wavefronts in mouse and human embryonic stem cell-derived cardiomyocytes. Stem Cells Dev. 2009 Dec; 18(10):1493-500. Lieu DK, Liu J, Siu CW, McNerney GP, Tse HF, Abu-Khalil A, Huser T, Li RA. PMID: 19290776.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    33. Label-free biochemical characterization of stem cells using vibrational spectroscopy. J Biophotonics. 2009 Nov; 2(11):656-68. Chan JW, Lieu DK. PMID: 19653219.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    34. Facilitated maturation of Ca2+ handling properties of human embryonic stem cell-derived cardiomyocytes by calsequestrin expression. . 2009 Jul; 297(1):C152-9. Liu J, Lieu DK, Siu CW, Fu JD, Tse HF, Li RA. PMID: 19357236.
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    35. Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopy. Anal Chem. 2009 Feb 15; 81(4):1324-31. Chan JW, Lieu DK, Huser T, Li RA. PMID: 19152312.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    36. Overexpression of HCN-encoded pacemaker current silences bioartificial pacemakers. Heart Rhythm. 2008 Sep; 5(9):1310-7. Lieu DK, Chan YC, Lau CP, Tse HF, Siu CW, Li RA. PMID: 18693074.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    37. Label-retaining cells of the bladder: candidate urothelial stem cells. Am J Physiol Renal Physiol. 2008 Jun; 294(6):F1415-21. Kurzrock EA, Lieu DK, Degraffenried LA, Chan CW, Isseroff RR. PMID: 18367656.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    38. HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering. J Membr Biol. 2006; 214(3):115-22. Siu CW, Lieu DK, Li RA. PMID: 17558529.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    39. Urothelial progenitor cells: regional differences in the rat bladder. Cell Prolif. 2007 Apr; 40(2):157-65. Nguyen MM, Lieu DK, deGraffenried LA, Isseroff RR, Kurzrock EA. PMID: 17472724.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    40. Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation. 2007 Apr 10; 115(14):1839-50. Xue T, Siu CW, Lieu DK, Lau CP, Tse HF, Li RA. PMID: 17389267.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    41. Beta1 integrin expression pattern in transitional urothelium does not allow for efficient stem cell enrichment as in other epithelia. Tissue Eng. 2007 Feb; 13(2):263-70. Lieu DK, Degraffenried LA, Isseroff RR, Kurzrock EA. PMID: 17518562.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    42. Ion Channels in Shear Stress Sensing in Vascular Endothelium. . 2007 Jan 1; 155-170. Abdul I. Barakat, Deborah K. Lieu, Andrea Gojova. .
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    43. Secrets of the code: do vascular endothelial cells use ion channels to decipher complex flow signals? Biomaterials. 2006 Feb; 27(5):671-8. Barakat AI, Lieu DK, Gojova A. PMID: 16112724.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    44. Rat urothelium: improved techniques for serial cultivation, expansion, freezing and reconstitution onto acellular matrix. J Urol. 2005 Jan; 173(1):281-5. Kurzrock EA, Lieu DK, deGraffenried LA, Isseroff RR. PMID: 15592097.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    45. Differential membrane potential and ion current responses to different types of shear stress in vascular endothelial cells. . 2004 Jun; 286(6):C1367-75. Lieu DK, Pappone PA, Barakat AI. PMID: 14761889.
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    46. Differential responsiveness of vascular endothelial cells to different types of fluid mechanical shear stress. Cell Biochem Biophys. 2003; 38(3):323-43. Barakat A, Lieu D. PMID: 12794271.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    47. Microchannel Platform for the Study of Endothelial Cell Shape and Function. Biomedical Microdevices. 2002 Mar 1; 4(1):9-16. Bonnie L. Gray, Deborah K. Lieu, Scott D. Collins, Rosemary L. Smith, Abdul I. Barakat. .
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    48. Stent-Induced Arterial Flow Disturbance: Whole Vessel and Cellular Considerations. . 2002 Jan 1; 287-288. Levanto G. Schachter, Deborah K. Lieu, Abdul I. Barakat. .
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