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Deborah Lieu

Title(s)Assistant Adjunct Professor, Cardiovascular Medicine
SchoolUniversity of California, Davis
Phone916-734-0683
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chang CW, Kao HKJ, Yechikov S, Lieu DK, Chan JW. An Intrinsic, Label-Free Signal for Identifying Stem Cell Derived Cardiomyocyte Subtype. Stem Cells. 2019 Nov 28. PMID: 31778240.
      View in: PubMed
    2. Sun YH, Kao HKJ, Chang CW, Merleev A, Overton JL, Pretto D, Yechikov S, Maverakis E, Chiamvimonvat N, Chan JW, Lieu DK. Human induced pluripotent stem cell line with genetically encoded fluorescent voltage indicator generated via CRISPR for action potential assessment post-cardiogenesis. Stem Cells. 2019 Sep 30. PMID: 31566285.
      View in: PubMed
    3. Wong AO, Wong G, Shen M, Chow MZ, Tse WW, Gurung B, Mak SY, Lieu DK, Costa KD, Chan CW, Martelli A, Nabhan JF, Li RA. Correlation between frataxin expression and contractility revealed by in vitro Friedreich's ataxia cardiac tissue models engineered from human pluripotent stem cells. Stem Cell Res Ther. 2019 Jul 08; 10(1):203. PMID: 31286988.
      View in: PubMed
    4. Yamoah MA, Moshref M, Sharma J, Chen WC, Ledford HA, Lee JH, Chavez KS, Wang W, López JE, Lieu DK, Sirish P, Zhang XD. Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles. Int J Nanomedicine. 2018; 13:6073-6078. PMID: 30323594.
      View in: PubMed
    5. Gluck JM, Herren AW, Yechikov S, Kao HKJ, Khan A, Phinney BS, Chiamvimonvat N, Chan JW, Lieu DK. Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix. PLoS One. 2017; 12(9):e0185125. PMID: 28934329.
      View in: PubMed
    6. Yechikov S, Copaciu R, Gluck JM, Deng W, Chiamvimonvat N, Chan JW, Lieu DK. Same-Single-Cell Analysis of Pacemaker-Specific Markers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Subtypes Classified by Electrophysiology. Stem Cells. 2016 11; 34(11):2670-2680. PMID: 27434649.
      View in: PubMed
    7. Sirish P, Li N, Timofeyev V, Zhang XD, Wang L, Yang J, Lee KS, Bettaieb A, Ma SM, Lee JH, Su D, Lau VC, Myers RE, Lieu DK, López JE, Young JN, Yamoah EN, Haj F, Ripplinger CM, Hammock BD, Chiamvimonvat N. Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2016 May; 9(5). PMID: 27162031.
      View in: PubMed
    8. Awasthi S, Izu LT, Mao Z, Jian Z, Landas T, Lerner A, Shimkunas R, Woldeyesus R, Bossuyt J, Wood BM, Chen YJ, Matthews DL, Lieu DK, Chiamvimonvat N, Lam KS, Chen-Izu Y, Chan JW. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes. Circ Res. 2016 01 22; 118(2):e19-28. PMID: 26643875.
      View in: PubMed
    9. Collier BB, Awasthi S, Lieu DK, Chan JW. Non-linear optical flow cytometry using a scanned, Bessel beam light-sheet. Sci Rep. 2015 May 29; 5:10751. PMID: 26021750.
      View in: PubMed
    10. Zhang XD, Lieu DK, Chiamvimonvat N. Small-conductance Ca2+ -activated K+ channels and cardiac arrhythmias. Heart Rhythm. 2015 Aug; 12(8):1845-51. PMID: 25956967.
      View in: PubMed
    11. Poon E, Keung W, Liang Y, Ramalingam R, Yan B, Zhang S, Chopra A, Moore J, Herren A, Lieu DK, Wong HS, Weng Z, Wong OT, Lam YW, Tomaselli GF, Chen C, Boheler KR, Li RA. Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation. Circ Cardiovasc Genet. 2015 Jun; 8(3):427-36. PMID: 25759434.
      View in: PubMed
    12. Karakikes I, Senyei GD, Hansen J, Kong CW, Azeloglu EU, Stillitano F, Lieu DK, Wang J, Ren L, Hulot JS, Iyengar R, Li RA, Hajjar RJ. Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes. Stem Cells Transl Med. 2014 Jan; 3(1):18-31. PMID: 24324277.
      View in: PubMed
    13. Zhang XD, Timofeyev V, Li N, Myers RE, Zhang DM, Singapuri A, Lau VC, Bond CT, Adelman J, Lieu DK, Chiamvimonvat N. Critical roles of a small conductance Ca²?-activated K? channel (SK3) in the repolarization process of atrial myocytes. Cardiovasc Res. 2014 Feb 01; 101(2):317-25. PMID: 24282291.
      View in: PubMed
    14. Poon E, Yan B, Zhang S, Rushing S, Keung W, Ren L, Lieu DK, Geng L, Kong CW, Wang J, Wong HS, Boheler KR, Li RA. Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes crucial for maturation. PLoS One. 2013; 8(10):e77784. PMID: 24204964.
      View in: PubMed
    15. Wang J, Chen A, Lieu DK, Karakikes I, Chen G, Keung W, Chan CW, Hajjar RJ, Costa KD, Khine M, Li RA. Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias. Biomaterials. 2013 Nov; 34(35):8878-86. PMID: 23942210.
      View in: PubMed
    16. Lieu DK, Fu JD, Chiamvimonvat N, Tung KC, McNerney GP, Huser T, Keller G, Kong CW, Li RA. Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes. Circ Arrhythm Electrophysiol. 2013 Feb; 6(1):191-201. PMID: 23392582.
      View in: PubMed
    17. Lieu DK, Turnbull IC, Costa KD, Li RA. Engineered human pluripotent stem cell-derived cardiac cells and tissues for electrophysiological studies. Drug Discov Today Dis Models. 2012; 9(4):e209-e217. PMID: 29422934.
      View in: PubMed
    18. Fu JD, Rushing SN, Lieu DK, Chan CW, Kong CW, Geng L, Wilson KD, Chiamvimonvat N, Boheler KR, Wu JC, Keller G, Hajjar RJ, Li RA. Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes. PLoS One. 2011; 6(11):e27417. PMID: 22110643.
      View in: PubMed
    19. Awasthi S, Matthews DL, Li RA, Chiamvimonvat N, Lieu DK, Chan JW. Label-free identification and characterization of human pluripotent stem cell-derived cardiomyocytes using second harmonic generation (SHG) microscopy. J Biophotonics. 2012 Jan; 5(1):57-66. PMID: 22083829.
      View in: PubMed
    20. Chen A, Lieu DK, Freschauf L, Lew V, Sharma H, Wang J, Nguyen D, Karakikes I, Hajjar RJ, Gopinathan A, Botvinick E, Fowlkes CC, Li RA, Khine M. Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives. Adv Mater. 2011 Dec 22; 23(48):5785-91. PMID: 22065428.
      View in: PubMed
    21. Luna JI, Ciriza J, Garcia-Ojeda ME, Kong M, Herren A, Lieu DK, Li RA, Fowlkes CC, Khine M, McCloskey KE. Multiscale biomimetic topography for the alignment of neonatal and embryonic stem cell-derived heart cells. Tissue Eng Part C Methods. 2011 May; 17(5):579-88. PMID: 21235325.
      View in: PubMed
    22. Rushing SN, Herren AW, Lieu DK, Li RA. Manipulations of microRNA in human pluripotent stem cells and their derivatives. Methods Mol Biol. 2011; 690:107-20. PMID: 21042988.
      View in: PubMed
    23. Lee YK, Ng KM, Lai WH, Man C, Lieu DK, Lau CP, Tse HF, Siu CW. Ouabain facilitates cardiac differentiation of mouse embryonic stem cells through ERK1/2 pathway. Acta Pharmacol Sin. 2011 Jan; 32(1):52-61. PMID: 21151160.
      View in: PubMed
    24. Jiang P, Rushing SN, Kong CW, Fu J, Lieu DK, Chan CW, Deng W, Li RA. Electrophysiological properties of human induced pluripotent stem cells. Am J Physiol Cell Physiol. 2010 Mar; 298(3):C486-95. PMID: 19955484.
      View in: PubMed
    25. Lieu DK, Liu J, Siu CW, McNerney GP, Tse HF, Abu-Khalil A, Huser T, Li RA. Absence of transverse tubules contributes to non-uniform Ca(2+) wavefronts in mouse and human embryonic stem cell-derived cardiomyocytes. Stem Cells Dev. 2009 Dec; 18(10):1493-500. PMID: 19290776.
      View in: PubMed
    26. Chan JW, Lieu DK. Label-free biochemical characterization of stem cells using vibrational spectroscopy. J Biophotonics. 2009 Nov; 2(11):656-68. PMID: 19653219.
      View in: PubMed
    27. Liu J, Lieu DK, Siu CW, Fu JD, Tse HF, Li RA. Facilitated maturation of Ca2+ handling properties of human embryonic stem cell-derived cardiomyocytes by calsequestrin expression. Am J Physiol Cell Physiol. 2009 Jul; 297(1):C152-9. PMID: 19357236.
      View in: PubMed
    28. Chan JW, Lieu DK, Huser T, Li RA. Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopy. Anal Chem. 2009 Feb 15; 81(4):1324-31. PMID: 19152312.
      View in: PubMed
    29. Lieu DK, Chan YC, Lau CP, Tse HF, Siu CW, Li RA. Overexpression of HCN-encoded pacemaker current silences bioartificial pacemakers. Heart Rhythm. 2008 Sep; 5(9):1310-7. PMID: 18693074.
      View in: PubMed
    30. Kurzrock EA, Lieu DK, Degraffenried LA, Chan CW, Isseroff RR. Label-retaining cells of the bladder: candidate urothelial stem cells. Am J Physiol Renal Physiol. 2008 Jun; 294(6):F1415-21. PMID: 18367656.
      View in: PubMed
    31. Siu CW, Lieu DK, Li RA. HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering. J Membr Biol. 2006; 214(3):115-22. PMID: 17558529.
      View in: PubMed
    32. Nguyen MM, Lieu DK, deGraffenried LA, Isseroff RR, Kurzrock EA. Urothelial progenitor cells: regional differences in the rat bladder. Cell Prolif. 2007 Apr; 40(2):157-65. PMID: 17472724.
      View in: PubMed
    33. Xue T, Siu CW, Lieu DK, Lau CP, Tse HF, Li RA. Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation. 2007 Apr 10; 115(14):1839-50. PMID: 17389267.
      View in: PubMed
    34. Lieu DK, Degraffenried LA, Isseroff RR, Kurzrock EA. Beta1 integrin expression pattern in transitional urothelium does not allow for efficient stem cell enrichment as in other epithelia. Tissue Eng. 2007 Feb; 13(2):263-70. PMID: 17518562.
      View in: PubMed
    35. Barakat AI, Lieu DK, Gojova A. Secrets of the code: do vascular endothelial cells use ion channels to decipher complex flow signals? Biomaterials. 2006 Feb; 27(5):671-8. PMID: 16112724.
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    36. Kurzrock EA, Lieu DK, deGraffenried LA, Isseroff RR. Rat urothelium: improved techniques for serial cultivation, expansion, freezing and reconstitution onto acellular matrix. J Urol. 2005 Jan; 173(1):281-5. PMID: 15592097.
      View in: PubMed
    37. Lieu DK, Pappone PA, Barakat AI. Differential membrane potential and ion current responses to different types of shear stress in vascular endothelial cells. Am J Physiol Cell Physiol. 2004 Jun; 286(6):C1367-75. PMID: 14761889.
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    38. Barakat A, Lieu D. Differential responsiveness of vascular endothelial cells to different types of fluid mechanical shear stress. Cell Biochem Biophys. 2003; 38(3):323-43. PMID: 12794271.
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