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Julie B C Bossuyt, DVM; PhD

Title(s)Associate Professor, Pharmacology
SchoolUniversity of California, Davis
Address451 Health Sciences Drive
CA 95616
Phone530-754-7419
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Aging Disrupts Normal Time-of-day Variation in Cardiac Electrophysiology. Circ Arrhythm Electrophysiol. 2020 Jul 24. Wang Z, Tapa S, Francis Stuart SD, Wang L, Bossuyt J, Delisle BP, Ripplinger CM. PMID: 32706628.
      View in: PubMed   Mentions:    Fields:    
    2. Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O-linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes. Circ Res. 2020 May 08; 126(10):e80-e96. Lu S, Liao Z, Lu X, Katschinski DM, Mercola M, Chen J, Heller Brown J, Molkentin JD, Bossuyt J, Bers DM. PMID: 32134364.
      View in: PubMed   Mentions:    Fields:    
    3. Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-Dependent and ß-Adrenergic Effects on Late Sodium, L-Type Calcium, and Sodium-Calcium Exchange Currents. Circ Arrhythm Electrophysiol. 2019 03; 12(3):e007061. Hegyi B, Morotti S, Liu C, Ginsburg KS, Bossuyt J, Belardinelli L, Izu LT, Chen-Izu Y, Bányász T, Grandi E, Bers DM. PMID: 30879336.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy. J Mol Cell Cardiol. 2019 02; 127:246-259. Hegyi B, Bers DM, Bossuyt J. PMID: 30633874.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Cardiac CaMKII activation promotes rapid translocation to its extra-dyadic targets. J Mol Cell Cardiol. 2018 12; 125:18-28. Wood BM, Simon M, Galice S, Alim CC, Ferrero M, Pinna NN, Bers DM, Bossuyt J. PMID: 30321537.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Complex electrophysiological remodeling in postinfarction ischemic heart failure. Proc Natl Acad Sci U S A. 2018 03 27; 115(13):E3036-E3044. Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varró A, Papp JG, Pollesello P, Levijoki J, Izu LT, Boyd WD, Bányász T, Bers DM, Chen-Izu Y. PMID: 29531045.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    7. Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and ß-Adrenergic Effects on Delayed- and Inward-Rectifier Potassium Currents. Circ Arrhythm Electrophysiol. 2018 02; 11(2):e005852. Hegyi B, Bossuyt J, Ginsburg KS, Mendoza LM, Talken L, Ferrier WT, Pogwizd SM, Izu LT, Chen-Izu Y, Bers DM. PMID: 29437761.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    8. Emergency Spatiotemporal Shift: The Response of Protein Kinase D to Stress Signals in the Cardiovascular System. Front Pharmacol. 2017; 8:9. Wood BM, Bossuyt J. PMID: 28174535.
      View in: PubMed   Mentions:
    9. L30A Mutation of Phospholemman Mimics Effects of Cardiac Glycosides in Isolated Cardiomyocytes. Biochemistry. 2016 Nov 08; 55(44):6196-6204. Himes RD, Smolin N, Kukol A, Bossuyt J, Bers DM, Robia SL. PMID: 27718550.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. Circ Res. 2016 Sep 30; 119(8):931-43. Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK. PMID: 27576469.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    11. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes. Circ Res. 2016 01 22; 118(2):e19-28. Awasthi S, Izu LT, Mao Z, Jian Z, Landas T, Lerner A, Shimkunas R, Woldeyesus R, Bossuyt J, Wood BM, Chen YJ, Matthews DL, Lieu DK, Chiamvimonvat N, Lam KS, Chen-Izu Y, Chan JW. PMID: 26643875.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. S-Nitrosylation Induces Both Autonomous Activation and Inhibition of Calcium/Calmodulin-dependent Protein Kinase II d. J Biol Chem. 2015 Oct 16; 290(42):25646-56. Erickson JR, Nichols CB, Uchinoumi H, Stein ML, Bossuyt J, Bers DM. PMID: 26316536.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    13. Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes. Proc Natl Acad Sci U S A. 2015 Mar 31; 112(13):3991-6. Pereira L, Rehmann H, Lao DH, Erickson JR, Bossuyt J, Chen J, Bers DM. PMID: 25829540.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    14. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol. 2015 Mar 15; 593(6):1361-82. Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. PMID: 25772291.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    15. Assessing GPCR and G protein signaling to the nucleus in live cells using fluorescent biosensors. Methods Mol Biol. 2015; 1234:149-59. Bossuyt J, Bers DM. PMID: 25304355.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. Nuclear remodelling: a consequence of nucleocytoplasmic traffic run amok? Cardiovasc Res. 2015 Jan 01; 105(1):6-7. Bossuyt J. PMID: 25504625.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    17. Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure. Circulation. 2014 Jul 15; 130(3):244-55. Ljubojevic S, Radulovic S, Leitinger G, Sedej S, Sacherer M, Holzer M, Winkler C, Pritz E, Mittler T, Schmidt A, Sereinigg M, Wakula P, Zissimopoulos S, Bisping E, Post H, Marsche G, Bossuyt J, Bers DM, Kockskämper J, Pieske B. PMID: 24928680.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    18. Junctional cleft [Ca²?]i measurements using novel cleft-targeted Ca²? sensors. Circ Res. 2014 Jul 18; 115(3):339-47. Despa S, Shui B, Bossuyt J, Lang D, Kotlikoff MI, Bers DM. PMID: 24871564.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    19. ß-adrenergic signaling inhibits Gq-dependent protein kinase D activation by preventing protein kinase D translocation. Circ Res. 2014 04 25; 114(9):1398-409. Nichols CB, Chang CW, Ferrero M, Wood BM, Stein ML, Ferguson AJ, Ha D, Rigor RR, Bossuyt S, Bossuyt J. PMID: 24643961.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. Visualizing CaMKII and CaM activity: a paradigm of compartmentalized signaling. J Mol Med (Berl). 2013 Aug; 91(8):907-16. Bossuyt J, Bers DM. PMID: 23775230.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    21. Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process. PLoS One. 2013; 8(3):e57324. Gold JI, Martini JS, Hullmann J, Gao E, Chuprun JK, Lee L, Tilley DG, Rabinowitz JE, Bossuyt J, Bers DM, Koch WJ. PMID: 23472081.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    22. Measuring local gradients of intramitochondrial [Ca(2+)] in cardiac myocytes during sarcoplasmic reticulum Ca(2+) release. Circ Res. 2013 Feb 01; 112(3):424-31. Lu X, Ginsburg KS, Kettlewell S, Bossuyt J, Smith GL, Bers DM. PMID: 23243207.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    23. Na?/K?-ATPase E960 and phospholemman F28 are critical for their functional interaction. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20756-61. Khafaga M, Bossuyt J, Mamikonian L, Li JC, Lee LL, Yarov-Yarovoy V, Despa S, Bers DM. PMID: 23185013.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    24. Acute ß-adrenergic activation triggers nuclear import of histone deacetylase 5 and delays G(q)-induced transcriptional activation. J Biol Chem. 2013 Jan 04; 288(1):192-204. Chang CW, Lee L, Yu D, Dao K, Bossuyt J, Bers DM. PMID: 23161540.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    25. The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. J Mol Cell Cardiol. 2012 Mar; 52(3):773-82. Haghighi K, Pritchard T, Bossuyt J, Waggoner JR, Yuan Q, Fan GC, Osinska H, Anjak A, Rubinstein J, Robbins J, Bers DM, Kranias EG. PMID: 22155237.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    26. Fluorescence resonance energy transfer-based sensor Camui provides new insight into mechanisms of calcium/calmodulin-dependent protein kinase II activation in intact cardiomyocytes. Circ Res. 2011 Sep 16; 109(7):729-38. Erickson JR, Patel R, Ferguson A, Bossuyt J, Bers DM. PMID: 21835909.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    27. Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin. J Biol Chem. 2011 Sep 23; 286(38):33390-400. Bossuyt J, Chang CW, Helmstadter K, Kunkel MT, Newton AC, Campbell KS, Martin JL, Bossuyt S, Robia SL, Bers DM. PMID: 21795686.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    28. RhoA protects the mouse heart against ischemia/reperfusion injury. J Clin Invest. 2011 Aug; 121(8):3269-76. Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW, Brown JH. PMID: 21747165.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    29. Phosphomimetic mutations enhance oligomerization of phospholemman and modulate its interaction with the Na/K-ATPase. J Biol Chem. 2011 Mar 18; 286(11):9120-6. Song Q, Pallikkuth S, Bossuyt J, Bers DM, Robia SL. PMID: 21220422.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    30. Role of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na+-K+-ATPase. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1363-9. Han F, Bossuyt J, Martin JL, Despa S, Bers DM. PMID: 20861470.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    31. Isoform specificity of the Na/K-ATPase association and regulation by phospholemman. J Biol Chem. 2009 Sep 25; 284(39):26749-57. Bossuyt J, Despa S, Han F, Hou Z, Robia SL, Lingrel JB, Bers DM. PMID: 19638348.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    32. Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets. J Biol Chem. 2008 Nov 14; 283(46):31531-40. Song Q, Saucerman JJ, Bossuyt J, Bers DM. PMID: 18790737.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    33. Phospholamban oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase binding measured by fluorescence resonance energy transfer in living cells. J Biol Chem. 2008 May 02; 283(18):12202-11. Kelly EM, Hou Z, Bossuyt J, Bers DM, Robia SL. PMID: 18287099.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    34. Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circ Res. 2008 Mar 28; 102(6):695-702. Bossuyt J, Helmstadter K, Wu X, Clements-Jewery H, Haworth RS, Avkiran M, Martin JL, Pogwizd SM, Bers DM. PMID: 18218981.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    35. Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes. Circ Res. 2006 Dec 08; 99(12):1376-83. Han F, Bossuyt J, Despa S, Tucker AL, Bers DM. PMID: 17095720.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    36. Regulation of Ca2+ and Na+ in normal and failing cardiac myocytes. Ann N Y Acad Sci. 2006 Oct; 1080:165-77. Bers DM, Despa S, Bossuyt J. PMID: 17132783.
      View in: PubMed   Mentions: 62     Fields:    
    37. Dynamic changes in free Ca-calmodulin levels in adult cardiac myocytes. J Mol Cell Cardiol. 2006 Sep; 41(3):451-8. Maier LS, Ziolo MT, Bossuyt J, Persechini A, Mestril R, Bers DM. PMID: 16765983.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    38. Phospholemman phosphorylation alters its fluorescence resonance energy transfer with the Na/K-ATPase pump. J Biol Chem. 2006 Oct 27; 281(43):32765-73. Bossuyt J, Despa S, Martin JL, Bers DM. PMID: 16943195.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    39. Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest. 2006 Mar; 116(3):675-82. Wu X, Zhang T, Bossuyt J, Li X, McKinsey TA, Dedman JR, Olson EN, Chen J, Brown JH, Bers DM. PMID: 16511602.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    40. Biosensors to measure inositol 1,4,5-trisphosphate concentration in living cells with spatiotemporal resolution. J Biol Chem. 2006 Jan 06; 281(1):608-16. Remus TP, Zima AV, Bossuyt J, Bare DJ, Martin JL, Blatter LA, Bers DM, Mignery GA. PMID: 16249182.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    41. Expression and phosphorylation of the na-pump regulatory subunit phospholemman in heart failure. Circ Res. 2005 Sep 16; 97(6):558-65. Bossuyt J, Ai X, Moorman JR, Pogwizd SM, Bers DM. PMID: 16100047.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    42. Phospholemman-phosphorylation mediates the beta-adrenergic effects on Na/K pump function in cardiac myocytes. Circ Res. 2005 Aug 05; 97(3):252-9. Despa S, Bossuyt J, Han F, Ginsburg KS, Jia LG, Kutchai H, Tucker AL, Bers DM. PMID: 16002746.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    43. Adenoviral gene transfer of mutant phospholamban rescues contractile dysfunction in failing rabbit myocytes with relatively preserved SERCA function. Circ Res. 2005 Apr 29; 96(8):815-7. Ziolo MT, Martin JL, Bossuyt J, Bers DM, Pogwizd SM. PMID: 15790952.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    44. Myocyte nitric oxide synthase 2 contributes to blunted beta-adrenergic response in failing human hearts by decreasing Ca2+ transients. Circulation. 2004 Apr 20; 109(15):1886-91. Ziolo MT, Maier LS, Piacentino V, Bossuyt J, Houser SR, Bers DM. PMID: 15037528.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    45. Sodium-calcium exchange crystallization. Ann N Y Acad Sci. 2002 Nov; 976:100-2. Hale CC, Bossuyt J, Hill CK, Price EM, Schulze DH, Lederer JW, Poljak R, Braden BC. PMID: 12502545.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    46. The cardiac sodium-calcium exchanger associates with caveolin-3. Ann N Y Acad Sci. 2002 Nov; 976:197-204. Bossuyt J, Taylor BE, James-Kracke M, Hale CC. PMID: 12502561.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    47. Evidence for cardiac sodium-calcium exchanger association with caveolin-3. FEBS Lett. 2002 Jan 30; 511(1-3):113-7. Bossuyt J, Taylor BE, James-Kracke M, Hale CC. PMID: 11821059.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    48. Expressing and purifying membrane transport proteins in high yield. J Biochem Biophys Methods. 2002 Jan 04; 50(2-3):233-43. Hale CC, Hill CK, Price EM, Bossuyt J. PMID: 11741710.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells