Amy R Brooks-Kayal

Title(s)Professor, Med: Neurology
SchoolSchool of Medicine
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    Other Positions
    Title(s)Department Chair, Med: Neurology


    Collapse Research 
    Collapse Research Activities and Funding
    The STAT3 response of excitatory neurons to epileptogenic brain injury
    NIH R56NS117141May 15, 2020 - Apr 30, 2021
    Role: Co-Principal Investigator
    2018 Mechanisms of Epilepsy and Neuronal Synchronization Gordon Research Conference and Gordon Research Seminar
    NIH R13NS106866May 1, 2018 - Apr 30, 2019
    Role: Principal Investigator
    Colorado Neurological Sciences Academic Development Award (NSADA)
    NIH K12NS089417Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Development of novel JAK/STAT inhibitors for Epilepsy prevention and treatment
    NIH R21NS083057Jan 1, 2014 - Dec 31, 2016
    Role: Principal Investigator
    GABA(A) Receptor Subunit Regulation in Epileptogenesis
    NIH R01NS051710Apr 1, 2005 - Jun 30, 2020
    Role: Principal Investigator
    GABA (A) Receptors in Developmental Epileptogenesis
    NIH R01NS038595Apr 1, 1999 - Nov 30, 2010
    Role: Principal Investigator
    DEVELOPMENTAL REGULATION OF GABAA RECEPTOR EXPRESSION
    NIH K08NS001936Jan 1, 1997 - Dec 31, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Ruxolitinib-dependent reduction of seizure load and duration is accompanied by spatial memory improvement in the rat pilocarpine model of temporal lobe epilepsy. Neurotherapeutics. 2024 Dec 05; e00506. Carrel A, Napoli E, Hixson K, Carlsen J, Cruz Del Angel Y, Strode D, Busquet N, Kumar V, Wempe MF, Russek SJ, Brooks-Kayal AR. PMID: 39643584.
      View in: PubMed   Mentions:
    2. Shifts in the spatiotemporal profile of inflammatory phenotypes of innate immune cells in the rat brain following acute intoxication with the organophosphate diisopropylfluorophosphate. J Neuroinflammation. 2024 Nov 04; 21(1):285. Andrew PM, MacMahon JA, Bernardino PN, Tsai YH, Hobson BA, Porter VA, Huddleston SL, Luo AS, Bruun DA, Saito NH, Harvey DJ, Brooks-Kayal A, Chaudhari AJ, Lein PJ. PMID: 39497181; PMCID: PMC11533402.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Neonatal Seizures. Neoreviews. 2024 Jun 01; 25(6):e338-e349. Stieren ES, Rottkamp CA, Brooks-Kayal AR. PMID: 38821905.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Selective Neuronal Knockout of STAT3 Function Inhibits Epilepsy Progression, Improves Cognition, and Restores Dysregulated Gene Networks in a Temporal Lobe Epilepsy Model. Ann Neurol. 2023 07; 94(1):106-122. Tipton AE, Cruz Del Angel Y, Hixson K, Carlsen J, Strode D, Busquet N, Mesches MH, Gonzalez MI, Napoli E, Russek SJ, Brooks-Kayal AR. PMID: 36935347; PMCID: PMC10313781.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    5. Precision Treatments in Epilepsy. Neurotherapeutics. 2021 07; 18(3):1429-1431. Demarest S, Brooks-Kayal A. PMID: 34704188; PMCID: PMC8608958.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Down-regulation of AMPA receptors and long-term potentiation during early epileptogenesis. Epilepsy Behav. 2021 Sep 27; 124:108320. Cruz Del Angel Y, Orfila JE, Herson PS, Brooks-Kayal A, González MI. PMID: 34592633.
      View in: PubMed   Mentions: 7     Fields:    
    7. Altered Protein Profiles During Epileptogenesis in the Pilocarpine Mouse Model of Temporal Lobe Epilepsy. Front Neurol. 2021; 12:654606. Ahmed MM, Carrel AJ, Cruz Del Angel Y, Carlsen J, Thomas AX, González MI, Gardiner KJ, Brooks-Kayal A. PMID: 34122302; PMCID: PMC8194494.
      View in: PubMed   Mentions: 7  
    8. Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap. Nat Rev Neurol. 2021 04; 17(4):231-242. Simonato M, Agoston DV, Brooks-Kayal A, Dulla C, Fureman B, Henshall DC, Pitkänen A, Theodore WH, Twyman RE, Kobeissy FH, Wang KK, Whittemore V, Wilcox KS. PMID: 33594276.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    9. Evidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain's major ion channels and neurotransmitter receptors. BMC Genomics. 2019 Aug 28; 20(1):677. Hixson KM, Cogswell M, Brooks-Kayal AR, Russek SJ. PMID: 31455240; PMCID: PMC6712773.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    10. The path from scientific discovery to cures for epilepsy. Neuropharmacology. 2020 05 01; 167:107702. Carvill GL, Dulla CG, Lowenstein DH, Brooks-Kayal AR. PMID: 31301334.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    11. Mechanisms of Epilepsy and Neuronal Synchronization Gordon Research Conference Power Hour Summary. Epilepsy Curr. 2019 Jul-Aug; 19(4):272-274. Isom LL, Wilcox KS, Brooks-Kayal A. PMID: 31282199; PMCID: PMC6891837.
      View in: PubMed   Mentions:
    12. From molecules to medicines: the dawn of targeted therapies for genetic epilepsies. Nat Rev Neurol. 2018 12; 14(12):735-745. Demarest ST, Brooks-Kayal A. PMID: 30448857.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    13. Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity Dependent Transcription of the GABA-A Receptor Beta 1 Subunit Gene in Neurons. Front Mol Neurosci. 2018; 11:285. Li Z, Cogswell M, Hixson K, Brooks-Kayal AR, Russek SJ. PMID: 30186109; PMCID: PMC6113564.
      View in: PubMed   Mentions: 18  
    14. Commonalities in epileptogenic processes from different acute brain insults: Do they translate? Epilepsia. 2018 01; 59(1):37-66. Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D, Sillanpää M, Sloviter RS, Steinhäuser C, Vezzani A, Walker MC, Löscher W. PMID: 29247482; PMCID: PMC5993212.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimals
    15. Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia. 2017 11; 58 Suppl 4:68-77. Simonato M, Iyengar S, Brooks-Kayal A, Collins S, Depaulis A, Howells DW, Jensen F, Liao J, Macleod MR, Patel M, Potschka H, Walker M, Whittemore V, Sena ES. PMID: 29105071.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    16. WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities. Epilepsia. 2017 03; 58(3):331-342. Ravizza T, Onat FY, Brooks-Kayal AR, Depaulis A, Galanopoulou AS, Mazarati A, Numis AL, Sankar R, Friedman A. PMID: 28035782; PMCID: PMC6582945.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    17. Rapid Increases in proBDNF after Pilocarpine-Induced Status Epilepticus in Mice Are Associated with Reduced proBDNF Cleavage Machinery. eNeuro. 2016 Jan-Feb; 3(1). Thomas AX, Cruz Del Angel Y, Gonzalez MI, Carrel AJ, Carlsen J, Lam PM, Hempstead BL, Russek SJ, Brooks-Kayal AR. PMID: 27057559; PMCID: PMC4814566.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    18. JAK/STAT pathway regulation of GABAA receptor expression after differing severities of experimental TBI. Exp Neurol. 2015 Sep; 271:445-56. Raible DJ, Frey LC, Del Angel YC, Carlsen J, Hund D, Russek SJ, Smith B, Brooks-Kayal AR. PMID: 26172316; PMCID: PMC5969808.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    19. Seizure-related regulation of GABAA receptors in spontaneously epileptic rats. Neurobiol Dis. 2015 May; 77:246-56. González MI, Grabenstatter HL, Cea-Del Rio CA, Cruz Del Angel Y, Carlsen J, Laoprasert RP, White AM, Huntsman MM, Brooks-Kayal A. PMID: 25769812; PMCID: PMC4415851.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    20. Effect of spontaneous seizures on GABAA receptor α4 subunit expression in an animal model of temporal lobe epilepsy. Epilepsia. 2014 Nov; 55(11):1826-33. Grabenstatter HL, Cogswell M, Cruz Del Angel Y, Carlsen J, Gonzalez MI, Raol YH, Russek SJ, Brooks-Kayal AR. PMID: 25223733; PMCID: PMC4596257.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    21. The challenge and promise of anti-epileptic therapy development in animal models. Lancet Neurol. 2014 Sep; 13(9):949-60. Simonato M, Brooks-Kayal AR, Engel J, Galanopoulou AS, Jensen FE, Moshé SL, O'Brien TJ, Pitkanen A, Wilcox KS, French JA. PMID: 25127174; PMCID: PMC5003536.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    22. Effects of JAK2-STAT3 signaling after cerebral insults. JAKSTAT. 2014; 3:e29510. Raible DJ, Frey LC, Brooks-Kayal AR. PMID: 25105066; PMCID: PMC4124058.
      View in: PubMed   Mentions: 23  
    23. Survey of the professors of child neurology: neurology versus pediatrics home for child neurology. Pediatr Neurol. 2014 Sep; 51(3):344-7. Pearl PL, McConnell ER, Fernandez R, Brooks-Kayal A. PMID: 24993248.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus. J Neurosci Res. 2014 Oct; 92(10):1307-18. Grabenstatter HL, Carlsen J, Raol YH, Yang T, Hund D, Cruz Del Angel Y, White AM, Gonzalez MI, Longo FM, Russek SJ, Brooks-Kayal AR. PMID: 24801281; PMCID: PMC4134742.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    25. Is plasticity of GABAergic mechanisms relevant to epileptogenesis? Adv Exp Med Biol. 2014; 813:133-50. Scharfman HE, Brooks-Kayal AR. PMID: 25012373; PMCID: PMC4370216.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    26. Authors' response to letter by A. Mazarati. Epilepsia. 2013 Dec; 54(12):2229-30. Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE. PMID: 24304440.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    27. The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. Neurobiol Dis. 2014 Feb; 62:73-85. Grabenstatter HL, Del Angel YC, Carlsen J, Wempe MF, White AM, Cogswell M, Russek SJ, Brooks-Kayal AR. PMID: 24051278; PMCID: PMC3908775.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    28. Subclinical early posttraumatic seizures detected by continuous EEG monitoring in a consecutive pediatric cohort. Epilepsia. 2013 Oct; 54(10):1780-8. Arndt DH, Lerner JT, Matsumoto JH, Madikians A, Yudovin S, Valino H, McArthur DL, Wu JY, Leung M, Buxey F, Szeliga C, Van Hirtum-Das M, Sankar R, Brooks-Kayal A, Giza CC. PMID: 24032982; PMCID: PMC4439105.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    29. Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia. 2013 Aug; 54 Suppl 4:44-60. Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE. PMID: 23909853; PMCID: PMC3924317.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimals
    30. Issues related to development of antiepileptogenic therapies. Epilepsia. 2013 Aug; 54 Suppl 4:35-43. Pitkänen A, Nehlig A, Brooks-Kayal AR, Dudek FE, Friedman D, Galanopoulou AS, Jensen FE, Kaminski RM, Kapur J, Klitgaard H, Löscher W, Mody I, Schmidt D. PMID: 23909852; PMCID: PMC3740390.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    31. Down-regulation of gephyrin and GABAA receptor subunits during epileptogenesis in the CA1 region of hippocampus. Epilepsia. 2013 Apr; 54(4):616-24. González MI, Cruz Del Angel Y, Brooks-Kayal A. PMID: 23294024; PMCID: PMC3618570.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    32. Molecular pathways controlling inhibitory receptor expression. Epilepsia. 2012 Dec; 53 Suppl 9:71-8. Grabenstatter HL, Russek SJ, Brooks-Kayal AR. PMID: 23216580; PMCID: PMC3776022.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    33. GABA(A) receptor regulation after experimental traumatic brain injury. J Neurotrauma. 2012 Nov 01; 29(16):2548-54. Raible DJ, Frey LC, Cruz Del Angel Y, Russek SJ, Brooks-Kayal AR. PMID: 22827467; PMCID: PMC3495117.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    34. Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette. Eur J Neurosci. 2012 Jun; 35(12):1857-65. Chapman KE, Raol YH, Brooks-Kayal A. PMID: 22708596; PMCID: PMC3383637.
      View in: PubMed   Mentions: 20  Translation:HumansAnimals
    35. Experimental models of seizures and epilepsies. Prog Mol Biol Transl Sci. 2012; 105:57-82. Raol YH, Brooks-Kayal AR. PMID: 22137429.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    36. Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons. J Neurochem. 2012 Jan; 120(2):210-9. Kim JH, Roberts DS, Hu Y, Lau GC, Brooks-Kayal AR, Farb DH, Russek SJ. PMID: 22035109; PMCID: PMC5116917.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    37. Altered GABA(A) receptor expression during epileptogenesis. Neurosci Lett. 2011 Jun 27; 497(3):218-22. González MI, Brooks-Kayal A. PMID: 21376781; PMCID: PMC3134403.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    38. Molecular mechanisms of cognitive and behavioral comorbidities of epilepsy in children. Epilepsia. 2011 Jan; 52 Suppl 1:13-20. Brooks-Kayal A. PMID: 21214535; PMCID: PMC3058310.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    39. Does acquired epileptogenesis in the immature brain require neuronal death. Epilepsy Curr. 2011 Jan; 11(1):21-6. Baram TZ, Jensen FE, Brooks-Kayal A. PMID: 21461261; PMCID: PMC3063568.
      View in: PubMed   Mentions: 20  
    40. Stress-hyperresponsive WKY rats demonstrate depressed dorsal raphe neuronal excitability and dysregulated CRF-mediated responses. Neuropsychopharmacology. 2011 Mar; 36(4):721-34. Lemos JC, Zhang G, Walsh T, Kirby LG, Akanwa A, Brooks-Kayal A, Beck SG. PMID: 21160465; PMCID: PMC3055727.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    41. Pediatric neurological complications of 2009 pandemic influenza A (H1N1). Arch Neurol. 2011 Apr; 68(4):455-62. Kedia S, Stroud B, Parsons J, Schreiner T, Curtis DJ, Bagdure D, Brooks-Kayal AR, Glode MP, Dominguez SR. PMID: 21149805; PMCID: PMC3096015.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCellsPHPublic Health
    42. Epilepsy and autism spectrum disorders: are there common developmental mechanisms? Brain Dev. 2010 Oct; 32(9):731-8. Brooks-Kayal A. PMID: 20570072.
      View in: PubMed   Mentions: 71     Fields:    Translation:Humans
    43. Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure. Neurobiol Dis. 2010 Sep; 39(3):439-48. McRae PA, Baranov E, Sarode S, Brooks-Kayal AR, Porter BE. PMID: 20493259; PMCID: PMC2935142.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    44. Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females. Brain. 2009 Jun; 132(Pt 6):1563-76. Marsh E, Fulp C, Gomez E, Nasrallah I, Minarcik J, Sudi J, Christian SL, Mancini G, Labosky P, Dobyns W, Brooks-Kayal A, Golden JA. PMID: 19439424; PMCID: PMC2685924.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    45. Alteration of epileptogenesis genes. Neurotherapeutics. 2009 Apr; 6(2):312-8. Brooks-Kayal AR, Raol YH, Russek SJ. PMID: 19332325; PMCID: PMC2700027.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    46. Curing epilepsy: progress and future directions. Epilepsy Behav. 2009 Mar; 14(3):438-45. Jacobs MP, Leblanc GG, Brooks-Kayal A, Jensen FE, Lowenstein DH, Noebels JL, Spencer DD, Swann JW. PMID: 19341977; PMCID: PMC2822433.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    47. A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Ann Neurol. 2009 Mar; 65(3):326-36. Raol YH, Lapides DA, Keating JG, Brooks-Kayal AR, Cooper EC. PMID: 19334075; PMCID: PMC2666110.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    48. BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathway. Sci Signal. 2008 Oct 14; 1(41):ra9. Lund IV, Hu Y, Raol YH, Benham RS, Faris R, Russek SJ, Brooks-Kayal AR. PMID: 18922788; PMCID: PMC2651003.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    49. FACS-array gene expression analysis during early development of mouse telencephalic interneurons. Dev Neurobiol. 2008 Mar; 68(4):434-45. Marsh ED, Minarcik J, Campbell K, Brooks-Kayal AR, Golden JA. PMID: 18172891.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    50. Surface expression of GABAA receptors is transcriptionally controlled by the interplay of cAMP-response element-binding protein and its binding partner inducible cAMP early repressor. J Biol Chem. 2008 Apr 04; 283(14):9328-40. Hu Y, Lund IV, Gravielle MC, Farb DH, Brooks-Kayal AR, Russek SJ. PMID: 18180303; PMCID: PMC2431045.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    51. Seizures and antiepileptic drugs: does exposure alter normal brain development? Epilepsia. 2006 Dec; 47(12):1999-2010. Marsh ED, Brooks-Kayal AR, Porter BE. PMID: 17201696.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    52. Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. J Neurosci. 2006 Nov 01; 26(44):11342-6. Raol YH, Lund IV, Bandyopadhyay S, Zhang G, Roberts DS, Wolfe JH, Russek SJ, Brooks-Kayal AR. PMID: 17079662; PMCID: PMC6674546.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimals
    53. Increased GABA(A)-receptor alpha1-subunit expression in hippocampal dentate gyrus after early-life status epilepticus. Epilepsia. 2006 Oct; 47(10):1665-73. Raol YH, Zhang G, Lund IV, Porter BE, Maronski MA, Brooks-Kayal AR. PMID: 17054689.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    54. Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons. J Biol Chem. 2006 Oct 06; 281(40):29431-5. Roberts DS, Hu Y, Lund IV, Brooks-Kayal AR, Russek SJ. PMID: 16901909.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    55. Status epilepticus differentially alters AMPA and kainate receptor subunit expression in mature and immature dentate granule neurons. Eur J Neurosci. 2006 Jun; 23(11):2857-63. Porter BE, Cui XN, Brooks-Kayal AR. PMID: 16819974.
      View in: PubMed   Mentions: 12  Translation:AnimalsCells
    56. Early postnatal stimulation alters pregnane neurosteroids in the hippocampus. Psychopharmacology (Berl). 2006 Jun; 186(3):343-50. Frye CA, Rhodes ME, Raol YH, Brooks-Kayal AR. PMID: 16491430; PMCID: PMC3608213.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    57. Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11894-9. Roberts DS, Raol YH, Bandyopadhyay S, Lund IV, Budreck EC, Passini MA, Passini MJ, Wolfe JH, Brooks-Kayal AR, Russek SJ. PMID: 16091474; PMCID: PMC1187961.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    58. Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients. Neurobiol Dis. 2005 Apr; 18(3):484-91. Porter BE, Zhang G, Celix J, Hsu FC, Raol YH, Telfeian A, Gallagher PR, Coulter DA, Brooks-Kayal AR. PMID: 15755675.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    59. Central nervous system hyperexcitability associated with glutamate dehydrogenase gain of function mutations. J Pediatr. 2005 Mar; 146(3):388-94. Raizen DM, Brooks-Kayal A, Steinkrauss L, Tennekoon GI, Stanley CA, Kelly A. PMID: 15756227.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    60. Rearranging receptors. Epilepsia. 2005; 46 Suppl 7:29-38. Brooks-Kayal AR. PMID: 16201993.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    61. Long-term effects of diazepam and phenobarbital treatment during development on GABA receptors, transporters and glutamic acid decarboxylase. Neuroscience. 2005; 132(2):399-407. Raol YH, Zhang G, Budreck EC, Brooks-Kayal AR. PMID: 15802192.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    62. Increased prevalence of unprovoked seizures in patients with a 22q11.2 deletion. Am J Med Genet A. 2004 Aug 15; 129A(1):29-34. Kao A, Mariani J, McDonald-McGinn DM, Maisenbacher MK, Brooks-Kayal AR, Zackai EH, Lynch DR. PMID: 15266612.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    63. Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility. J Neurochem. 2004 Jan; 88(1):91-101. Zhang G, Raol YS, Hsu FC, Brooks-Kayal AR. PMID: 14675153.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    64. Fate of newborn dentate granule cells after early life status epilepticus. Epilepsia. 2004 Jan; 45(1):13-9. Porter BE, Maronski M, Brooks-Kayal AR. PMID: 14692902.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    65. Effects of status epilepticus on hippocampal GABAA receptors are age-dependent. Neuroscience. 2004; 125(2):299-303. Zhang G, Raol YH, Hsu FC, Coulter DA, Brooks-Kayal AR. PMID: 15062973; PMCID: PMC2441871.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    66. Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12213-8. Hsu FC, Zhang GJ, Raol YS, Valentino RJ, Coulter DA, Brooks-Kayal AR. PMID: 14530409; PMCID: PMC218738.
      View in: PubMed   Mentions: 61     Fields:    Translation:Animals
    67. Epilepsy after early-life seizures can be independent of hippocampal injury. Ann Neurol. 2003 Apr; 53(4):503-11. Raol YS, Budreck EC, Brooks-Kayal AR. PMID: 12666118.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    68. Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy. Epilepsia. 2002 Mar; 43(3):211-8. Crino PB, Jin H, Shumate MD, Robinson MB, Coulter DA, Brooks-Kayal AR. PMID: 11906504; PMCID: PMC2441873.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    69. Disorders of cortical development and epilepsy. Arch Neurol. 2002 Mar; 59(3):361-5. Porter BE, Brooks-Kayal A, Golden JA. PMID: 11890838.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    70. gamma-Aminobutyric acid(A) receptor subunit expression predicts functional changes in hippocampal dentate granule cells during postnatal development. J Neurochem. 2001 Jun; 77(5):1266-78. Brooks-Kayal AR, Shumate MD, Jin H, Rikhter TY, Kelly ME, Coulter DA. PMID: 11389177.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    71. Role of excitatory amino acids in developmental epilepsies. Ment Retard Dev Disabil Res Rev. 2001; 7(4):254-60. Raol YH, Lynch DR, Brooks-Kayal AR. PMID: 11754519.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    72. Treatment of acquired epileptic aphasia with the ketogenic diet. J Child Neurol. 1999 Nov; 14(11):696-701. Bergqvist AG, Chee CM, Lutchka LM, Brooks-Kayal AR. PMID: 10593544.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    73. Human neuronal gamma-aminobutyric acid(A) receptors: coordinated subunit mRNA expression and functional correlates in individual dentate granule cells. J Neurosci. 1999 Oct 01; 19(19):8312-8. Brooks-Kayal AR, Shumate MD, Jin H, Lin DD, Rikhter TY, Holloway KL, Coulter DA. PMID: 10493732; PMCID: PMC6783026.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    74. A 15-year-old with back pain, fever, and leg numbness. Semin Pediatr Neurol. 1999 Sep; 6(3):190-4; discussion 194-5. Strober JB, Zuppa A, Brooks-Kayal AR. PMID: 10522338.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    75. A 4-year-old with pica, progressive incoordination, and decreased responsiveness. Semin Pediatr Neurol. 1999 Sep; 6(3):164-7. Dlugos DJ, Brooks-Kayal AR. PMID: 10522333.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    76. Language-related cognitive declines after left temporal lobectomy in children. Pediatr Neurol. 1999 Jul; 21(1):444-9. Dlugos DJ, Moss EM, Duhaime AC, Brooks-Kayal AR. PMID: 10428428.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    77. Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nat Med. 1998 Oct; 4(10):1166-72. Brooks-Kayal AR, Shumate MD, Jin H, Rikhter TY, Coulter DA. PMID: 9771750.
      View in: PubMed   Mentions: 249     Fields:    Translation:AnimalsCells
    78. The glutamate transporter, GLT-1, is expressed in cultured hippocampal neurons. Neurochem Int. 1998 Aug; 33(2):95-100. Brooks-Kayal AR, Munir M, Jin H, Robinson MB. PMID: 9761452.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    79. Developmental expression of GABA(A) receptor subunit mRNAs in individual hippocampal neurons in vitro and in vivo. J Neurochem. 1998 Mar; 70(3):1017-28. Brooks-Kayal AR, Jin H, Price M, Dichter MA. PMID: 9489721.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    80. Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors. Mol Pharmacol. 1997 May; 51(5):833-41. Amin J, Brooks-Kayal A, Weiss DS. PMID: 9145922.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    81. Tonic pupil and orbital glial-neural hamartoma in infancy. Am J Ophthalmol. 1995 Jun; 119(6):809-11. Brooks-Kayal AR, Liu GT, Menacker SJ, Heher KL, Katowitz JA, Bilaniuk LT. PMID: 7785705.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    82. Developmental changes in human gamma-aminobutyric acidA receptor subunit composition. Ann Neurol. 1993 Nov; 34(5):687-93. Brooks-Kayal AR, Pritchett DB. PMID: 7694542.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
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