Bethany P Cummings

Title(s)Associate Professor, Surgery
SchoolUniversity of California, Davis
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    Collapse Research 
    Collapse Research Activities and Funding
    Mapping bile acid metabolism across the gut microbiome in response to dietary fiber
    NIH R21AT010956May 1, 2021 - Apr 30, 2023
    Role: Principal Investigator
    Defining alpha-cell proglucagon processing for type 2 diabetes treatment
    NIH R56DK124853Sep 15, 2020 - Aug 31, 2021
    Role: Principal Investigator
    Efficacy of bariatric surgery to decrease the risk of colorectal cancer in mice
    NIH R21CA195002Apr 1, 2016 - Mar 31, 2019
    Role: Principal Investigator
    Dissecting mechanisms by which GI surgery delays diabetes onset in UCD-T2DM rats
    NIH R01DK095960Jul 1, 2012 - Apr 30, 2017
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Diet-dependent sex differences in the response to vertical sleeve gastrectomy. Am J Physiol Endocrinol Metab. 2021 07 01; 321(1):E11-E23. Hutch CR, Stelmak D, Kanke M, Koch-Laskowski K, Cummings B, Griffin C, Leix K, Sethupathy P, Singer K, Sandoval DA. PMID: 33998293.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells. JCI Insight. 2021 02 08; 6(3). Saikia M, Holter MM, Donahue LR, Lee IS, Zheng QC, Wise JL, Todero JE, Phuong DJ, Garibay D, Coch R, Sloop KW, Garcia-Ocana A, Danko CG, Cummings BP. PMID: 33554958.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Impact of fecal microbiota transplantation with capsules on the prevention of metabolic syndrome among patients with obesity. Hormones (Athens). 2021 Mar; 20(1):209-211. Allegretti JR, Kassam Z, Hurtado J, Marchesi JR, Mullish BH, Chiang A, Thompson CC, Cummings BP. PMID: 33420959.
      View in: PubMed   Mentions:    Fields:    
    4. Bariatric surgery works through a novel bile acid. Nat Chem Biol. 2021 01; 17(1):5-6. Cummings BP. PMID: 32848213.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Synovial fluid lubricin increases in spontaneous canine cruciate ligament rupture. Sci Rep. 2020 10 07; 10(1):16725. Wang Y, Gludish DW, Hayashi K, Todhunter RJ, Krotscheck U, Johnson PJ, Cummings BP, Su J, Reesink HL. PMID: 33028842.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. TGR5 Signaling in Hepatic Metabolic Health. Nutrients. 2020 Aug 26; 12(9). Holter MM, Chirikjian MK, Govani VN, Cummings BP. PMID: 32859104.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice. Nutrients. 2020 Jul 17; 12(7). Holter MM, Chirikjian MK, Briere DA, Maida A, Sloop KW, Schoonjans K, Cummings BP. PMID: 32708970.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Hepatocyte p53 ablation induces metabolic dysregulation that is corrected by food restriction and vertical sleeve gastrectomy in mice. FASEB J. 2020 01; 34(1):1846-1858. Holter MM, Garibay D, Lee SA, Saikia M, McGavigan AK, Ngyuen L, Moore ES, Daugherity E, Cohen P, Kelly K, Weiss RS, Cummings BP. PMID: 31914635.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. Sex-specific hepatic lipid and bile acid metabolism alterations in Fancd2-deficient mice following dietary challenge. J Biol Chem. 2019 10 25; 294(43):15623-15637. Moore ES, Daugherity EK, Karambizi DI, Cummings BP, Behling-Kelly E, Schaefer DMW, Southard TL, McFadden JW, Weiss RS. PMID: 31434739.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    10. TGR5 Protects Against Colitis in Mice, but Vertical Sleeve Gastrectomy Increases Colitis Severity. Obes Surg. 2019 05; 29(5):1593-1601. Garibay D, Zaborska KE, Shanahan M, Zheng Q, Kelly KM, Montrose DC, Dannenberg AJ, Miller AD, Sethupathy P, Cummings BP. PMID: 30623320.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Peptide YY (PYY) Is Expressed in Human Skeletal Muscle Tissue and Expanding Human Muscle Progenitor Cells. Front Physiol. 2019; 10:188. Gheller BJ, Blum JE, Merritt EK, Cummings BP, Thalacker-Mercer AE. PMID: 30890955.
      View in: PubMed   Mentions: 3  
    12. Rethinking Bile Acid Metabolism and Signaling for Type 2 Diabetes Treatment. Curr Diab Rep. 2018 09 19; 18(11):109. Zaborska KE, Cummings BP. PMID: 30232649.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    13. Temporal Regulation of the Bacterial Metabolite Deoxycholate during Colonic Repair Is Critical for Crypt Regeneration. . 2018 09 12; 24(3):353-363.e5. Jain U, Lai CW, Xiong S, Goodwin VM, Lu Q, Muegge BD, Christophi GP, VanDussen KL, Cummings BP, Young E, Hambor J, Stappenbeck TS. PMID: 30122655.
      View in: PubMed   Mentions: 17  Translation:AnimalsCells
    14. Deoxycholic acid supplementation impairs glucose homeostasis in mice. PLoS One. 2018; 13(7):e0200908. Zaborska KE, Lee SA, Garribay D, Cha E, Cummings BP. PMID: 30059528.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. β Cell GLP-1R Signaling Alters α Cell Proglucagon Processing after Vertical Sleeve Gastrectomy in Mice. Cell Rep. 2018 04 24; 23(4):967-973. Garibay D, Lou J, Lee SA, Zaborska KE, Weissman MH, Sloma E, Donahue L, Miller AD, White AC, Michael MD, Sloop KW, Cummings BP. PMID: 29694904.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. A Murine Model of Vertical Sleeve Gastrectomy. J Vis Exp. 2017 12 18; (130). Garibay D, Cummings BP. PMID: 29286478.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    17. Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice. Dis Model Mech. 2017 03 01; 10(3):235-243. McGavigan AK, Henseler ZM, Garibay D, Butler SD, Jayasinghe S, Ley RE, Davisson RL, Cummings BP. PMID: 28093508.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    18. β-Cell Glucagon-Like Peptide-1 Receptor Contributes to Improved Glucose Tolerance After Vertical Sleeve Gastrectomy. Endocrinology. 2016 09; 157(9):3405-9. Garibay D, McGavigan AK, Lee SA, Ficorilli JV, Cox AL, Michael MD, Sloop KW, Cummings BP. PMID: 27501183.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    19. Evaluation of plasma inflammatory cytokine concentrations in racing sled dogs. Can Vet J. 2015 Dec; 56(12):1252-6. von Pfeil DJ, Cummings BP, Loftus JP, Levine CB, Mann S, Downey RL, Griffitts C, Wakshlag JJ. PMID: 26663920.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    20. Dry period plane of energy: Effects on glucose tolerance in transition dairy cows. J Dairy Sci. 2016 Jan; 99(1):701-17. Mann S, Leal Yepes FA, Duplessis M, Wakshlag JJ, Overton TR, Cummings BP, Nydam DV. PMID: 26627861.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    21. TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice. Gut. 2017 02; 66(2):226-234. McGavigan AK, Garibay D, Henseler ZM, Chen J, Bettaieb A, Haj FG, Ley RE, Chouinard ML, Cummings BP. PMID: 26511794.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    22. Increasing body condition score is positively associated interleukin-6 and monocyte chemoattractant protein-1 in Labrador retrievers. Vet Immunol Immunopathol. 2015 Oct 15; 167(3-4):104-9. Frank L, Mann S, Levine CB, Cummings BP, Wakshlag JJ. PMID: 26235599.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    23. miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β. Nat Commun. 2015 Apr 15; 6:6879. Bu P, Wang L, Chen KY, Rakhilin N, Sun J, Closa A, Tung KL, King S, Kristine Varanko A, Xu Y, Huan Chen J, Zessin AS, Shealy J, Cummings B, Hsu D, Lipkin SM, Moreno V, Gümüs ZH, Shen X. PMID: 25872451.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    24. The associations between serum adiponectin, leptin, C-reactive protein, insulin, and serum long-chain omega-3 fatty acids in Labrador Retrievers. Vet Med (Auckl). 2015; 6:103-110. Streeter RM, Struble AM, Mann S, Nydam DV, Bauer JE, Castelhano MG, Todhunter RJ, Cummings BP, Wakshlag JJ. PMID: 30155437.
      View in: PubMed   Mentions: 1  
    25. Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes. Biochim Biophys Acta. 2014 Sep; 1842(9):1313-23. Agrawal R, Zhuang Y, Cummings BP, Stanhope KL, Graham JL, Havel PJ, Gomez-Pinilla F. PMID: 24840661.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    26. Administration of pioglitazone alone or with alogliptin delays diabetes onset in UCD-T2DM rats. J Endocrinol. 2014 Apr; 221(1):133-44. Cummings BP, Bettaieb A, Graham JL, Stanhope K, Haj FG, Havel PJ. PMID: 24627447.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    27. The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat. Regul Pept. 2014 Feb 10; 189:31-9. Hansen CF, Vassiliadis E, Vrang N, Sangild PT, Cummings BP, Havel P, Jelsing J. PMID: 24512816.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    28. Maternal ileal interposition surgery confers metabolic improvements to offspring independent of effects on maternal body weight in UCD-T2DM rats. Obes Surg. 2013 Dec; 23(12):2042-9. Cummings BP, Graham JL, Stanhope KL, Chouinard ML, Havel PJ. PMID: 24036841.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    29. Duodenal exclusion devices: promising tools in treating obesity and type 2 diabetes. Gut. 2014 Aug; 63(8):1201-2. Cummings BP. PMID: 24221455.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    30. Fish oil supplementation ameliorates fructose-induced hypertriglyceridemia and insulin resistance in adult male rhesus macaques. J Nutr. 2014 Jan; 144(1):5-11. Bremer AA, Stanhope KL, Graham JL, Cummings BP, Ampah SB, Saville BR, Havel PJ. PMID: 24108131.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    31. Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. J Biol Chem. 2013 Jun 14; 288(24):17360-71. Bettaieb A, Bakke J, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B, Graham J, Bremer A, Zhang S, Lyssiotis CA, Zhang ZY, Cantley LC, Havel PJ, Haj FG. PMID: 23640882.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    32. Loss of coupling between calcium influx, energy consumption and insulin secretion associated with development of hyperglycaemia in the UCD-T2DM rat model of type 2 diabetes. Diabetologia. 2013 Apr; 56(4):803-13. Rountree AM, Reed BJ, Cummings BP, Jung SR, Stanhope KL, Graham JL, Griffen SC, Hull RL, Havel PJ, Sweet IR. PMID: 23404441.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    33. Leptin therapy in type 2 diabetes. Diabetes Obes Metab. 2013 Jul; 15(7):607-12. Cummings BP. PMID: 23216672.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    34. Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques. J Endocrinol. 2013 Feb; 216(2):207-15. Cummings BP, Bremer AA, Kieffer TJ, D'Alessio D, Havel PJ. PMID: 23151361.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    35. Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats. Dis Model Mech. 2013 Mar; 6(2):443-56. Cummings BP, Bettaieb A, Graham JL, Kim J, Ma F, Shibata N, Stanhope KL, Giulivi C, Hansen F, Jelsing J, Vrang N, Kowala M, Chouinard ML, Haj FG, Havel PJ. PMID: 23264565.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    36. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. . 2012 Oct 01; 303(7):H853-62. Guglielmino K, Jackson K, Harris TR, Vu V, Dong H, Dutrow G, Evans JE, Graham J, Cummings BP, Havel PJ, Chiamvimonvat N, Despa S, Hammock BD, Despa F. PMID: 22865388.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    37. Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM rats. Endocrinology. 2012 Aug; 153(8):3620-32. Cummings BP, Bettaieb A, Graham JL, Stanhope KL, Kowala M, Haj FG, Chouinard ML, Havel PJ. PMID: 22719048.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    38. Glucose sensing by gut endocrine cells and activation of the vagal afferent pathway is impaired in a rodent model of type 2 diabetes mellitus. . 2012 Mar 15; 302(6):R657-66. Lee J, Cummings BP, Martin E, Sharp JW, Graham JL, Stanhope KL, Havel PJ, Raybould HE. PMID: 22160540.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    39. Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14670-5. Cummings BP, Bettaieb A, Graham JL, Stanhope KL, Dill R, Morton GJ, Haj FG, Havel PJ. PMID: 21873226.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    40. Fructose-fed rhesus monkeys: a nonhuman primate model of insulin resistance, metabolic syndrome, and type 2 diabetes. Clin Transl Sci. 2011 Aug; 4(4):243-52. Bremer AA, Stanhope KL, Graham JL, Cummings BP, Wang W, Saville BR, Havel PJ. PMID: 21884510.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    41. Supplementation with EPA or fish oil for 11 months lowers circulating lipids, but does not delay the onset of diabetes in UC Davis-type 2 diabetes mellitus rats. Br J Nutr. 2010 Dec; 104(11):1628-34. Cummings BP, Stanhope KL, Graham JL, Griffen SC, Havel PJ. PMID: 20735878.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    42. Chronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM rats. Diabetes. 2010 Oct; 59(10):2653-61. Cummings BP, Stanhope KL, Graham JL, Baskin DG, Griffen SC, Nilsson C, Sams A, Knudsen LB, Raun K, Havel PJ. PMID: 20622169.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    43. Ileal interposition surgery improves glucose and lipid metabolism and delays diabetes onset in the UCD-T2DM rat. Gastroenterology. 2010 Jun; 138(7):2437-46, 2446.e1. Cummings BP, Strader AD, Stanhope KL, Graham JL, Lee J, Raybould HE, Baskin DG, Havel PJ. PMID: 20226188.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    44. Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, alpha-lipoic acid. . 2010 May; 298(5):R1343-50. Cummings BP, Stanhope KL, Graham JL, Evans JL, Baskin DG, Griffen SC, Havel PJ. PMID: 20147607.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    45. Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses. J Clin Endocrinol Metab. 2009 May; 94(5):1562-9. Teff KL, Grudziak J, Townsend RR, Dunn TN, Grant RW, Adams SH, Keim NL, Cummings BP, Stanhope KL, Havel PJ. PMID: 19208729.
      View in: PubMed   Mentions: 112     Fields:    Translation:Humans
    46. Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM rat. . 2008 Dec; 295(6):R1782-93. Cummings BP, Digitale EK, Stanhope KL, Graham JL, Baskin DG, Reed BJ, Sweet IR, Griffen SC, Havel PJ. PMID: 18832086.
      View in: PubMed   Mentions: 52  Translation:AnimalsCells
    47. Metabolic and endocrine profiles in response to systemic infusion of fructose and glucose in rhesus macaques. Endocrinology. 2008 Jun; 149(6):3002-8. Adams SH, Stanhope KL, Grant RW, Cummings BP, Havel PJ. PMID: 18308841.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals