Mark Huising

Title(s)Professor, MED: Physiology & Membrane Biol
SchoolSchool of Medicine
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    Title(s)Professor, Neurobiology, Physiology and Behavior


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    PARACRINE FEEDBACK BY PANCREATIC DELTA CELLS TO CONTROL GLUCAGON AND INSULIN RELEASE AND MANAGE DIABETES
    NIH R01DK110276Jul 1, 2017 - Jun 30, 2022
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of GCK -MODY. bioRxiv. 2024 Nov 11. Salazar S, Delgadillo-Silva LF, Carapeto P, Dakessian K, Melhem R, Provencher-Girard A, Ostinelli G, Turgeon J, Kaci I, Migneault F, Huising MO, Hébert MJ, Rutter GA. PMID: 39605321; PMCID: PMC11601264.
      View in: PubMed   Mentions:
    2. Myosin II tension sensors visualize force generation within the actin cytoskeleton in living cells. J Cell Sci. 2024 Oct 04. Hart RG, Kota D, Li F, Zhang M, Ramallo D, Price AJ, Otterpohl KL, Smith SJ, Dunn AR, Huising MO, Liu J, Chandrasekar I. PMID: 39369303.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Urocortin 3 contributes to paracrine inhibition of islet alpha cells in mice. J Endocrinol. 2024 Jun 01; 261(3). Noguchi GM, Castillo VC, Donaldson CJ, Flisher MR, Momen AT, Saghatelian A, Huising MO. PMID: 38593829; PMCID: PMC11095665.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice. Nat Metab. 2024 Jan; 6(1):61-77. Huang JL, Pourhosseinzadeh MS, Lee S, Krämer N, Guillen JV, Cinque NH, Aniceto P, Momen AT, Koike S, Huising MO. PMID: 38195859; PMCID: PMC10919447.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    5. An Intraislet Paracrine Signaling Pathway That Enables Glucagon to Stimulate Pancreatic β-Cells. Diabetes. 2023 Dec 01; 72(12):1748-1750. Caicedo A, Huising MO, Wess J. PMID: 37983525; PMCID: PMC10658067.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    6. US universities must tackle their huge carbon footprints. Nature. 2023 Nov; 623(7985):32. Huising MO, Aron AR. PMID: 37907634.
      View in: PubMed   Mentions:    Fields:    
    7. Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation. Elife. 2023 08 23; 12. Tixi W, Maldonado M, Chang YT, Chiu A, Yeung W, Parveen N, Nelson MS, Hart R, Wang S, Hsu WJ, Fueger P, Kopp JL, Huising MO, Dhawan S, Shih HP. PMID: 37610090; PMCID: PMC10482429.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    8. Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity. JCI Insight. 2023 08 22; 8(16). Cha J, Tong X, Walker EM, Dahan T, Cochrane VA, Ashe S, Russell R, Osipovich AB, Mawla AM, Guo M, Liu JH, Loyd ZA, Huising MO, Magnuson MA, Hebrok M, Dor Y, Stein R. PMID: 37606041; PMCID: PMC10543725.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Editorial: The pancreatic islet - a multifaceted hub of inter-cellular communication. Front Endocrinol (Lausanne). 2023; 14:1182897. Zhang Q, Huising MO, Da Silva Xavier G, Hauge-Evans AC. PMID: 37265699; PMCID: PMC10230102.
      View in: PubMed   Mentions: 1     Fields:    
    10. Chromatin accessibility differences between alpha, beta, and delta cells identifies common and cell type-specific enhancers. BMC Genomics. 2023 Apr 17; 24(1):202. Mawla AM, van der Meulen T, Huising MO. PMID: 37069576; PMCID: PMC10108528.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. Nutrient regulation of the islet epigenome controls adaptive insulin secretion. J Clin Invest. 2023 04 17; 133(8). Wortham M, Liu F, Harrington AR, Fleischman JY, Wallace M, Mulas F, Mallick M, Vinckier NK, Cross BR, Chiou J, Patel NA, Sui Y, McGrail C, Jun Y, Wang G, Jhala US, Schüle R, Shirihai OS, Huising MO, Gaulton KJ, Metallo CM, Sander M. PMID: 36821378; PMCID: PMC10104905.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    12. A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. Nat Cell Biol. 2023 04; 25(4):565-578. Rubio-Navarro A, Gómez-Banoy N, Stoll L, Dündar F, Mawla AM, Ma L, Cortada E, Zumbo P, Li A, Reiterer M, Montoya-Oviedo N, Homan EA, Imai N, Gilani A, Liu C, Naji A, Yang B, Chong ACN, Cohen DE, Chen S, Cao J, Pitt GS, Huising MO, Betel D, Lo JC. PMID: 36928765; PMCID: PMC10449536.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    13. Dynamic Ins2 Gene Activity Defines β-Cell Maturity States. Diabetes. 2022 12 01; 71(12):2612-2631. Chu CMJ, Modi H, Ellis C, Krentz NAJ, Skovsø S, Zhao YB, Cen H, Noursadeghi N, Panzhinskiy E, Hu X, Dionne DA, Xia YH, Xuan S, Huising MO, Kieffer TJ, Lynn FC, Johnson JD. PMID: 36170671.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    14. β-Cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes. Diabetes. 2022 07 01; 71(7):1439-1453. Lee S, Xu H, Van Vleck A, Mawla AM, Li AM, Ye J, Huising MO, Annes JP. PMID: 35472723; PMCID: PMC9233299.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    15. Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity. Peptides. 2022 05; 151:170748. Flisher MF, Shin D, Huising MO. PMID: 35065098; PMCID: PMC10881066.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes Care. 2022 01 01; 45(1):3-22. Cefalu WT, Andersen DK, Arreaza-Rubín G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND, Symposium planning committee, moderators, and speakers. PMID: 34782355; PMCID: PMC8753760.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    17. Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes. 2021 11 13. Cefalu WT, Andersen DK, Arreaza-Rubín G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND, Symposium planning committee, moderators, and speakers:, Rosenblum N, Cefalu W, Andersen DK, Arreaza-Rubín G, Dhara C, James SP, Makarchuk MJ, Pin CL, Sato S, Verchere B, Woo M, Powers A, Estall J, Hoesli C, Millman J, Linnemann A, Johnson J, Pin CL, Hawkins M, Woo M, Gloyn A, Cefalu W, Rosenblum N, Huising MO, Benninger RKP, Almaça J, Hull-Meichle RL, MacDonald P, Lynn F, Melero-Martin J, Yoshihara E, Stabler C, Sander M, Evans-Molina C, Engin F, Thompson P, Shalev A, Redondo MJ, Nadeau K, Bellin M, Udler MS, Dennis J, Dash S, Zhou W, Snyder M, Booth G, Butte A, Florez J. PMID: 34957490.
      View in: PubMed   Mentions: 3     Fields:    
    18. IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes. Diabetologia. 2022 01; 65(1):173-187. Blencowe M, Furterer A, Wang Q, Gao F, Rosenberger M, Pei L, Nomoto H, Mawla AM, Huising MO, Coppola G, Yang X, Butler PC, Gurlo T. PMID: 34554282; PMCID: PMC8660728.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    19. Temporal coding of ERK signalling in β-cells. Nat Rev Endocrinol. 2021 09; 17(9):517-518. Huising MO, Albeck JG. PMID: 34168342.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering. Lancet Diabetes Endocrinol. 2021 10; 9(10):708-724. Krentz NAJ, Shea LD, Huising MO, Shaw JAM. PMID: 34480875; PMCID: PMC10881068.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    21. Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic β-cell dysfunction and loss. Free Radic Biol Med. 2021 08 20; 172:48-57. Koike S, Hsu MF, Bettaieb A, Chu B, Matsumoto N, Morisseau C, Havel PJ, Huising MO, Hammock BD, Haj FG. PMID: 34038767; PMCID: PMC9901526.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    22. Virgin β-Cells at the Neogenic Niche Proliferate Normally and Mature Slowly. Diabetes. 2021 05; 70(5):1070-1083. Lee S, Zhang J, Saravanakumar S, Flisher MF, Grimm DR, van der Meulen T, Huising MO. PMID: 33563657; PMCID: PMC8173805.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    23. Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice. Mol Metab. 2021 03; 45:101166. Croze ML, Flisher MF, Guillaume A, Tremblay C, Noguchi GM, Granziera S, Vivot K, Castillo VC, Campbell SA, Ghislain J, Huising MO, Poitout V. PMID: 33484949; PMCID: PMC7873385.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    24. Loss of sympathetic innervation to islets of Langerhans in canine diabetes and pancreatitis is not associated with insulitis. Sci Rep. 2020 11 05; 10(1):19187. Gilor C, Pires J, Greathouse R, Horn R, Huising MO, Marks SL, Murphy B, Kol A. PMID: 33154408; PMCID: PMC7645777.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    25. Paracrine regulation of insulin secretion. Diabetologia. 2020 10; 63(10):2057-2063. Huising MO. PMID: 32894316; PMCID: PMC7968070.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    26. Genetic deletion of Urocortin 3 does not prevent functional maturation of beta cells. J Endocrinol. 2020 07; 246(1):69-78. Huang JL, Lee S, Hoek P, van der Meulen T, Van R, Huising MO. PMID: 32369775; PMCID: PMC7286360.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    27. Author Correction: CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep. Sci Rep. 2020 May 05; 10(1):7500. Vilarino M, Rashid ST, Suchy FP, McNabb BR, van der Meulen T, Fine EJ, Ahsan SD, Mursaliyev N, Sebastiano V, Diab SS, Huising MO, Nakauchi H, Ross PJ. PMID: 32371904; PMCID: PMC7200707.
      View in: PubMed   Mentions: 1     Fields:    
    28. The effect of the ghrelin-receptor agonist capromorelin on glucose metabolism in healthy cats. Domest Anim Endocrinol. 2021 01; 74:106484. Pires J, Greathouse RL, Quach N, Huising MO, Crakes KR, Miller M, Gilor C. PMID: 32619812.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    29. Integrating the inputs that shape pancreatic islet hormone release. Nat Metab. 2019 12; 1(12):1189-1201. Noguchi GM, Huising MO. PMID: 32694675; PMCID: PMC7378277.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    30. Navigating the Depths and Avoiding the Shallows of Pancreatic Islet Cell Transcriptomes. Diabetes. 2019 07; 68(7):1380-1393. Mawla AM, Huising MO. PMID: 31221802; PMCID: PMC6609986.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    31. The Difference δ-Cells Make in Glucose Control. Physiology (Bethesda). 2018 11 01; 33(6):403-411. Huising MO, van der Meulen T, Huang JL, Pourhosseinzadeh MS, Noguchi GM. PMID: 30303773; PMCID: PMC6347098.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    32. Mosaicism diminishes the value of pre-implantation embryo biopsies for detecting CRISPR/Cas9 induced mutations in sheep. Transgenic Res. 2018 12; 27(6):525-537. Vilarino M, Suchy FP, Rashid ST, Lindsay H, Reyes J, McNabb BR, van der Meulen T, Huising MO, Nakauchi H, Ross PJ. PMID: 30284144.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    33. Evidence for a Neogenic Niche at the Periphery of Pancreatic Islets. Bioessays. 2018 11; 40(11):e1800119. Huising MO, Lee S, van der Meulen T. PMID: 30264410; PMCID: PMC6570402.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    34. The somatostatin-secreting pancreatic δ-cell in health and disease. Nat Rev Endocrinol. 2018 07; 14(7):404-414. Rorsman P, Huising MO. PMID: 29773871; PMCID: PMC5997567.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    35. CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep. Sci Rep. 2017 Dec 12; 7(1):17472. Vilarino M, Rashid ST, Suchy FP, McNabb BR, van der Meulen T, Fine EJ, Ahsan SD, Mursaliyev N, Sebastiano V, Diab SS, Huising MO, Nakauchi H, Ross PJ. PMID: 29234093; PMCID: PMC5727233.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    36. Artemether Does Not Turn α Cells into β Cells. Cell Metab. 2018 01 09; 27(1):218-225.e4. van der Meulen T, Lee S, Noordeloos E, Donaldson CJ, Adams MW, Noguchi GM, Mawla AM, Huising MO. PMID: 29103923; PMCID: PMC5762275.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    37. Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation. Cell Metab. 2017 May 02; 25(5):1160-1175.e11. Zeng C, Mulas F, Sui Y, Guan T, Miller N, Tan Y, Liu F, Jin W, Carrano AC, Huising MO, Shirihai OS, Yeo GW, Sander M. PMID: 28467932; PMCID: PMC5501713.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    38. Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene. Front Genet. 2017; 8:41. Pullen TJ, Huising MO, Rutter GA. PMID: 28443133; PMCID: PMC5385341.
      View in: PubMed   Mentions: 35  
    39. Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets. Cell Metab. 2017 Apr 04; 25(4):911-926.e6. van der Meulen T, Mawla AM, DiGruccio MR, Adams MW, Nies V, Dólleman S, Liu S, Ackermann AM, Cáceres E, Hunter AE, Kaestner KH, Donaldson CJ, Huising MO. PMID: 28380380; PMCID: PMC8586897.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCells
    40. The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass. Appl Physiol Nutr Metab. 2017 Jun; 42(6):647-655. Paglialunga S, Simnett G, Robson H, Hoang M, Pillai R, Arkell AM, Simpson JA, Bonen A, Huising M, Joseph JW, Holloway GP. PMID: 28177704.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    41. Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing. Endocrinology. 2016 Dec; 157(12):4865-4874. Pilbrow AP, Lewis KA, Perrin MH, Sweet WE, Moravec CS, Tang WH, Huising MO, Troughton RW, Cameron VA. PMID: 27754786; PMCID: PMC5133347.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    42. Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets. Mol Metab. 2016 Jul; 5(7):449-458. DiGruccio MR, Mawla AM, Donaldson CJ, Noguchi GM, Vaughan J, Cowing-Zitron C, van der Meulen T, Huising MO. PMID: 27408771; PMCID: PMC4921781.
      View in: PubMed   Mentions: 185     Fields:    
    43. Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2. J Biol Chem. 2015 Oct 23; 290(43):25997-6006. Hogan MF, Ravnskjaer K, Matsumura S, Huising MO, Hull RL, Kahn SE, Montminy M. PMID: 26342077; PMCID: PMC4646253.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    44. Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion. Nat Med. 2015 Jul; 21(7):769-76. van der Meulen T, Donaldson CJ, Cáceres E, Hunter AE, Cowing-Zitron C, Pound LD, Adams MW, Zembrzycki A, Grove KL, Huising MO. PMID: 26076035; PMCID: PMC4496282.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsCells
    45. Role of transcription factors in the transdifferentiation of pancreatic islet cells. J Mol Endocrinol. 2015 Apr; 54(2):R103-17. van der Meulen T, Huising MO. PMID: 25791577; PMCID: PMC4373662.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    46. Tuning to the right signal. Diabetologia. 2015 Jun; 58(6):1146-8. Huising MO. PMID: 25810040.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    47. Data-driven synthesis of proteolysis-resistant peptide hormones. J Am Chem Soc. 2014 Dec 24; 136(51):17710-3. Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. PMID: 25496053.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    48. CRFR1 activation protects against cytokine-induced β-cell death. J Mol Endocrinol. 2014 Dec; 53(3):417-27. Blaabjerg L, Christensen GL, Matsumoto M, van der Meulen T, Huising MO, Billestrup N, Vale WW. PMID: 25324488; PMCID: PMC4518718.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    49. The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression. BMC Genomics. 2014 Jul 22; 15:620. Benner C, van der Meulen T, Cacéres E, Tigyi K, Donaldson CJ, Huising MO. PMID: 25051960; PMCID: PMC4124169.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    50. TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling. Cell. 2014 May 22; 157(5):1023-36. Riera CE, Huising MO, Follett P, Leblanc M, Halloran J, Van Andel R, de Magalhaes Filho CD, Merkwirth C, Dillin A. PMID: 24855942.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    51. Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3. Rev Diabet Stud. 2014; 11(1):115-32. van der Meulen T, Huising MO. PMID: 25148370; PMCID: PMC4295803.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    52. Corticotropin-releasing factor-binding protein (CRF-BP) inhibits CRF- and urotensin-I-mediated activation of CRF receptor-1 and -2 in common carp. Gen Comp Endocrinol. 2014 Jun 01; 202:69-75. Manuel R, Metz JR, Flik G, Vale WW, Huising MO. PMID: 24769042.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    53. Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion. J Biol Chem. 2013 Aug 09; 288(32):23128-40. Jensen MV, Haldeman JM, Zhang H, Lu D, Huising MO, Vale WW, Hohmeier HE, Rosenberg P, Newgard CB. PMID: 23788641; PMCID: PMC3743485.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    54. Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells. PLoS One. 2012; 7(12):e52181. van der Meulen T, Xie R, Kelly OG, Vale WW, Sander M, Huising MO. PMID: 23251699; PMCID: PMC3522648.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    55. Recombinant human leptin attenuates stress axis activity in common carp (Cyprinus carpio L.). Gen Comp Endocrinol. 2012 Aug 01; 178(1):75-81. Gorissen M, Bernier NJ, Manuel R, de Gelder S, Metz JR, Huising MO, Flik G. PMID: 22543190.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    56. STAT genes display differential evolutionary rates that correlate with their roles in the endocrine and immune system. J Endocrinol. 2011 May; 209(2):175-84. Gorissen M, de Vrieze E, Flik G, Huising MO. PMID: 21330334.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    57. Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2α in MIN6 insulinoma cells and rodent islets. Endocrinology. 2011 Jan; 152(1):138-50. Huising MO, Pilbrow AP, Matsumoto M, van der Meulen T, Park H, Vaughan JM, Lee S, Vale WW. PMID: 21106875; PMCID: PMC3219054.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    58. CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):912-7. Huising MO, van der Meulen T, Vaughan JM, Matsumoto M, Donaldson CJ, Park H, Billestrup N, Vale WW. PMID: 20080775; PMCID: PMC2818901.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    59. Two divergent leptin paralogues in zebrafish (Danio rerio) that originate early in teleostean evolution. J Endocrinol. 2009 Jun; 201(3):329-39. Gorissen M, Bernier NJ, Nabuurs SB, Flik G, Huising MO. PMID: 19293295.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    60. Residues of corticotropin releasing factor-binding protein (CRF-BP) that selectively abrogate binding to CRF but not to urocortin 1. J Biol Chem. 2008 Apr 04; 283(14):8902-12. Huising MO, Vaughan JM, Shah SH, Grillot KL, Donaldson CJ, Rivier J, Flik G, Vale WW. PMID: 18234674; PMCID: PMC2276373.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    61. Corticotropin-releasing factor (CRF) and CRF-binding protein expression in and release from the head kidney of common carp: evolutionary conservation of the adrenal CRF system. J Endocrinol. 2007 Jun; 193(3):349-57. Huising MO, van der Aa LM, Metz JR, de Fátima Mazon A, Kemenade BM, Flik G. PMID: 17535873.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    62. Endurance exercise differentially stimulates heart and axial muscle development in zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2006 Oct; 291(4):R1040-8. van der Meulen T, Schipper H, van den Boogaart JG, Huising MO, Kranenbarg S, van Leeuwen JL. PMID: 16966387.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    63. Central and peripheral interleukin-1beta and interleukin-1 receptor I expression and their role in the acute stress response of common carp, Cyprinus carpio L. J Endocrinol. 2006 Oct; 191(1):25-35. Metz JR, Huising MO, Leon K, Verburg-van Kemenade BM, Flik G. PMID: 17065386.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    64. Increased leptin expression in common Carp (Cyprinus carpio) after food intake but not after fasting or feeding to satiation. Endocrinology. 2006 Dec; 147(12):5786-97. Huising MO, Geven EJ, Kruiswijk CP, Nabuurs SB, Stolte EH, Spanings FA, Verburg-van Kemenade BM, Flik G. PMID: 16935838.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    65. Real-time gene expression analysis in carp (Cyprinus carpio L.) skin: inflammatory responses to injury mimicking infection with ectoparasites. Dev Comp Immunol. 2007; 31(3):244-54. Gonzalez SF, Huising MO, Stakauskas R, Forlenza M, Lidy Verburg-van Kemenade BM, Buchmann K, Nielsen ME, Wiegertjes GF. PMID: 17034853.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    66. Phylogeny and evolution of class-I helical cytokines. J Endocrinol. 2006 Apr; 189(1):1-25. Huising MO, Kruiswijk CP, Flik G. PMID: 16614377.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    67. The first appearance of Rodlet cells in carp (Cyprinus carpio L.) ontogeny and their possible roles during stress and parasite infection. Fish Shellfish Immunol. 2007 Jan-Feb; 22(1-2):27-37. Mazon AF, Huising MO, Taverne-Thiele AJ, Bastiaans J, Verburg-van Kemenade BM. PMID: 16843681.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    68. The presence of multiple and differentially regulated interleukin-12p40 genes in bony fishes signifies an expansion of the vertebrate heterodimeric cytokine family. Mol Immunol. 2006 Apr; 43(10):1519-33. Huising MO, van Schijndel JE, Kruiswijk CP, Nabuurs SB, Savelkoul HF, Flik G, Verburg-van Kemenade BM. PMID: 16460805.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    69. Corticotropin-releasing hormone-receptor 1 (CRH-R1) and CRH-binding protein (CRH-BP) are expressed in the gills and skin of common carp Cyprinus carpio L. and respond to acute stress and infection. J Exp Biol. 2006 Feb; 209(Pt 3):510-7. Mazon AF, Verburg-van Kemenade BM, Flik G, Huising MO. PMID: 16424101.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    70. CRF and stress in fish. Gen Comp Endocrinol. 2006 Mar; 146(1):36-44. Flik G, Klaren PH, Van den Burg EH, Metz JR, Huising MO. PMID: 16403502.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    71. Multiple and highly divergent IL-11 genes in teleost fish. Immunogenetics. 2005 Jul; 57(6):432-43. Huising MO, Kruiswijk CP, van Schijndel JE, Savelkoul HF, Flik G, Verburg-van Kemenade BM. PMID: 16003467.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    72. Regulation of the stress response in early vertebrates. Ann N Y Acad Sci. 2005 Apr; 1040:345-7. Huising MO, Metz JR, De Mazon AF, Verburg-van Kemenade BM, Flik G. PMID: 15891057.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    73. The remarkable conservation of corticotropin-releasing hormone (CRH)-binding protein in the honeybee (Apis mellifera) dates the CRH system to a common ancestor of insects and vertebrates. Endocrinology. 2005 May; 146(5):2165-70. Huising MO, Flik G. PMID: 15718273.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    74. Rag expression identifies B and T cell lymphopoietic tissues during the development of common carp (Cyprinus carpio). Dev Comp Immunol. 2005; 29(12):1033-47. Huttenhuis HB, Huising MO, van der Meulen T, van Oosterhoud CN, Sánchez NA, Taverne-Thiele AJ, Stroband HW, Rombout JH. PMID: 15967501.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    75. Overproduction of corticotropin-releasing hormone blocks germinal center formation: role of corticosterone and impaired follicular dendritic cell networks. J Neuroimmunol. 2004 Nov; 156(1-2):31-41. Murray SE, Rosenzweig HL, Johnson M, Huising MO, Sawicki K, Stenzel-Poore MP. PMID: 15465594.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    76. Three novel carp CXC chemokines are expressed early in ontogeny and at nonimmune sites. Eur J Biochem. 2004 Oct; 271(20):4094-106. Huising MO, van der Meulen T, Flik G, Verburg-van Kemenade BM. PMID: 15479238.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    77. Localization, expression and control of adrenocorticotropic hormone in the nucleus preopticus and pituitary gland of common carp (Cyprinus carpio L.). J Endocrinol. 2004 Jul; 182(1):23-31. Metz JR, Huising MO, Meek J, Taverne-Thiele AJ, Wendelaar Bonga SE, Flik G. PMID: 15225128.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    78. Structural characterisation of a cyprinid (Cyprinus carpio L.) CRH, CRH-BP and CRH-R1, and the role of these proteins in the acute stress response. J Mol Endocrinol. 2004 Jun; 32(3):627-48. Huising MO, Metz JR, van Schooten C, Taverne-Thiele AJ, Hermsen T, Verburg-van Kemenade BM, Flik G. PMID: 15171705.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    79. The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish. Dev Comp Immunol. 2004 May 03; 28(5):395-413. Huising MO, Stet RJ, Savelkoul HF, Verburg-van Kemenade BM. PMID: 15062640.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    80. CXC chemokines and leukocyte chemotaxis in common carp (Cyprinus carpio L.). Dev Comp Immunol. 2003 Dec; 27(10):875-88. Huising MO, Stolte E, Flik G, Savelkoul HF, Verburg-van Kemenade BM. PMID: 12880637.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    81. Increased efficacy of immersion vaccination in fish with hyperosmotic pretreatment. Vaccine. 2003 Oct 01; 21(27-30):4178-93. Huising MO, Guichelaar T, Hoek C, Verburg-van Kemenade BM, Flik G, Savelkoul HF, Rombout JH. PMID: 14505897.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    82. Molecular evolution of CXC chemokines: extant CXC chemokines originate from the CNS. Trends Immunol. 2003 Jun; 24(6):307-13. Huising MO, Stet RJ, Kruiswijk CP, Savelkoul HF, Lidy Verburg-van Kemenade BM. PMID: 12810106.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    83. Neuroendocrine-immune interactions in fish: a role for interleukin-1. Vet Immunol Immunopathol. 2002 Sep 10; 87(3-4):467-79. Engelsma MY, Huising MO, van Muiswinkel WB, Flik G, Kwang J, Savelkoul HF, Verburg-van Kemenade BM. PMID: 12072274.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    84. Drinking in (very young) fish. Symp Soc Exp Biol. 2002; (54):31-47. Flik G, Varsamos S, Guerreiro PM, Fuentes X, Huising MO, Fenwick JC. PMID: 14992143.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
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