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Mark Huising

Title(s)Associate Professor, Physiology and Membrane Biology
SchoolUniversity of California, Davis
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    PARACRINE FEEDBACK BY PANCREATIC DELTA CELLS TO CONTROL GLUCAGON AND INSULIN RELEASE AND MANAGE DIABETES
    NIH/NIDDK R01DK110276Jul 1, 2017 - Jun 30, 2022
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Paracrine regulation of insulin secretion. Diabetologia. 2020 Oct; 63(10):2057-2063. Huising MO. PMID: 32894316.
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    2. Genetic deletion of Urocortin 3 does not prevent functional maturation of beta cells. J Endocrinol. 2020 Jul; 246(1):69-78. Huang JL, Lee S, Hoek P, van der Meulen T, Van R, Huising MO. PMID: 32369775.
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    3. Author Correction: CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep. Sci Rep. 2020 May 05; 10(1):7500. Vilarino M, Rashid ST, Suchy FP, McNabb BR, van der Meulen T, Fine EJ, Ahsan SD, Mursaliyev N, Sebastiano V, Diab SS, Huising MO, Nakauchi H, Ross PJ. PMID: 32371904.
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    4. The effect of the ghrelin-receptor agonist capromorelin on glucose metabolism in healthy cats. Domest Anim Endocrinol. 2020 Apr 18; 74:106484. Pires J, Greathouse RL, Quach N, Huising MO, Crakes KR, Miller M, Gilor C. PMID: 32619812.
      View in: PubMed   Mentions:    Fields:    
    5. Integrating the inputs that shape pancreatic islet hormone release. Nat Metab. 2019 Dec; 1(12):1189-1201. Noguchi GM, Huising MO. PMID: 32694675.
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    6. Navigating the Depths and Avoiding the Shallows of Pancreatic Islet Cell Transcriptomes. Diabetes. 2019 07; 68(7):1380-1393. Mawla AM, Huising MO. PMID: 31221802.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. The Difference d-Cells Make in Glucose Control. Physiology (Bethesda). 2018 11 01; 33(6):403-411. Huising MO, van der Meulen T, Huang JL, Pourhosseinzadeh MS, Noguchi GM. PMID: 30303773.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. Mosaicism diminishes the value of pre-implantation embryo biopsies for detecting CRISPR/Cas9 induced mutations in sheep. Transgenic Res. 2018 12; 27(6):525-537. Vilarino M, Suchy FP, Rashid ST, Lindsay H, Reyes J, McNabb BR, van der Meulen T, Huising MO, Nakauchi H, Ross PJ. PMID: 30284144.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    9. Evidence for a Neogenic Niche at the Periphery of Pancreatic Islets. Bioessays. 2018 11; 40(11):e1800119. Huising MO, Lee S, van der Meulen T. PMID: 30264410.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. The somatostatin-secreting pancreatic d-cell in health and disease. Nat Rev Endocrinol. 2018 07; 14(7):404-414. Rorsman P, Huising MO. PMID: 29773871.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    11. CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep. Sci Rep. 2017 12 12; 7(1):17472. Vilarino M, Rashid ST, Suchy FP, McNabb BR, van der Meulen T, Fine EJ, Ahsan SD, Mursaliyev N, Sebastiano V, Diab SS, Huising MO, Nakauchi H, Ross PJ. PMID: 29234093.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    12. Artemether Does Not Turn a Cells into ß Cells. Cell Metab. 2018 01 09; 27(1):218-225.e4. van der Meulen T, Lee S, Noordeloos E, Donaldson CJ, Adams MW, Noguchi GM, Mawla AM, Huising MO. PMID: 29103923.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    13. Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal ß Cell Proliferation. Cell Metab. 2017 May 02; 25(5):1160-1175.e11. Zeng C, Mulas F, Sui Y, Guan T, Miller N, Tan Y, Liu F, Jin W, Carrano AC, Huising MO, Shirihai OS, Yeo GW, Sander M. PMID: 28467932.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    14. Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11ß-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene. Front Genet. 2017; 8:41. Pullen TJ, Huising MO, Rutter GA. PMID: 28443133.
      View in: PubMed   Mentions:
    15. Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets. Cell Metab. 2017 Apr 04; 25(4):911-926.e6. van der Meulen T, Mawla AM, DiGruccio MR, Adams MW, Nies V, Dólleman S, Liu S, Ackermann AM, Cáceres E, Hunter AE, Kaestner KH, Donaldson CJ, Huising MO. PMID: 28380380.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    16. The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and ß-cell mass. Appl Physiol Nutr Metab. 2017 Jun; 42(6):647-655. Paglialunga S, Simnett G, Robson H, Hoang M, Pillai R, Arkell AM, Simpson JA, Bonen A, Huising M, Joseph JW, Holloway GP. PMID: 28177704.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    17. Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing. Endocrinology. 2016 Dec; 157(12):4865-4874. Pilbrow AP, Lewis KA, Perrin MH, Sweet WE, Moravec CS, Tang WH, Huising MO, Troughton RW, Cameron VA. PMID: 27754786.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets. Mol Metab. 2016 Jul; 5(7):449-458. DiGruccio MR, Mawla AM, Donaldson CJ, Noguchi GM, Vaughan J, Cowing-Zitron C, van der Meulen T, Huising MO. PMID: 27408771.
      View in: PubMed   Mentions: 58     Fields:    
    19. Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2. J Biol Chem. 2015 Oct 23; 290(43):25997-6006. Hogan MF, Ravnskjaer K, Matsumura S, Huising MO, Hull RL, Kahn SE, Montminy M. PMID: 26342077.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    20. Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion. Nat Med. 2015 Jul; 21(7):769-76. van der Meulen T, Donaldson CJ, Cáceres E, Hunter AE, Cowing-Zitron C, Pound LD, Adams MW, Zembrzycki A, Grove KL, Huising MO. PMID: 26076035.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    21. Role of transcription factors in the transdifferentiation of pancreatic islet cells. J Mol Endocrinol. 2015 Apr; 54(2):R103-17. van der Meulen T, Huising MO. PMID: 25791577.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    22. Tuning to the right signal. Diabetologia. 2015 Jun; 58(6):1146-8. Huising MO. PMID: 25810040.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    23. Data-driven synthesis of proteolysis-resistant peptide hormones. J Am Chem Soc. 2014 Dec 24; 136(51):17710-3. Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. PMID: 25496053.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. CRFR1 activation protects against cytokine-induced ß-cell death. J Mol Endocrinol. 2014 Dec; 53(3):417-27. Blaabjerg L, Christensen GL, Matsumoto M, van der Meulen T, Huising MO, Billestrup N, Vale WW. PMID: 25324488.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression. BMC Genomics. 2014 Jul 22; 15:620. Benner C, van der Meulen T, Cacéres E, Tigyi K, Donaldson CJ, Huising MO. PMID: 25051960.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    26. TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling. Cell. 2014 May 22; 157(5):1023-36. Riera CE, Huising MO, Follett P, Leblanc M, Halloran J, Van Andel R, de Magalhaes Filho CD, Merkwirth C, Dillin A. PMID: 24855942.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    27. Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3. Rev Diabet Stud. 2014; 11(1):115-32. van der Meulen T, Huising MO. PMID: 25148370.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    28. Corticotropin-releasing factor-binding protein (CRF-BP) inhibits CRF- and urotensin-I-mediated activation of CRF receptor-1 and -2 in common carp. Gen Comp Endocrinol. 2014 Jun 01; 202:69-75. Manuel R, Metz JR, Flik G, Vale WW, Huising MO. PMID: 24769042.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    29. Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion. J Biol Chem. 2013 Aug 09; 288(32):23128-40. Jensen MV, Haldeman JM, Zhang H, Lu D, Huising MO, Vale WW, Hohmeier HE, Rosenberg P, Newgard CB. PMID: 23788641.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    30. Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells. PLoS One. 2012; 7(12):e52181. van der Meulen T, Xie R, Kelly OG, Vale WW, Sander M, Huising MO. PMID: 23251699.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    31. Recombinant human leptin attenuates stress axis activity in common carp (Cyprinus carpio L.). Gen Comp Endocrinol. 2012 Aug 01; 178(1):75-81. Gorissen M, Bernier NJ, Manuel R, de Gelder S, Metz JR, Huising MO, Flik G. PMID: 22543190.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    32. STAT genes display differential evolutionary rates that correlate with their roles in the endocrine and immune system. J Endocrinol. 2011 May; 209(2):175-84. Gorissen M, de Vrieze E, Flik G, Huising MO. PMID: 21330334.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    33. Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2a in MIN6 insulinoma cells and rodent islets. Endocrinology. 2011 Jan; 152(1):138-50. Huising MO, Pilbrow AP, Matsumoto M, van der Meulen T, Park H, Vaughan JM, Lee S, Vale WW. PMID: 21106875.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    34. CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):912-7. Huising MO, van der Meulen T, Vaughan JM, Matsumoto M, Donaldson CJ, Park H, Billestrup N, Vale WW. PMID: 20080775.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    35. Two divergent leptin paralogues in zebrafish (Danio rerio) that originate early in teleostean evolution. J Endocrinol. 2009 Jun; 201(3):329-39. Gorissen M, Bernier NJ, Nabuurs SB, Flik G, Huising MO. PMID: 19293295.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    36. Residues of corticotropin releasing factor-binding protein (CRF-BP) that selectively abrogate binding to CRF but not to urocortin 1. J Biol Chem. 2008 Apr 04; 283(14):8902-12. Huising MO, Vaughan JM, Shah SH, Grillot KL, Donaldson CJ, Rivier J, Flik G, Vale WW. PMID: 18234674.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    37. Corticotropin-releasing factor (CRF) and CRF-binding protein expression in and release from the head kidney of common carp: evolutionary conservation of the adrenal CRF system. J Endocrinol. 2007 Jun; 193(3):349-57. Huising MO, van der Aa LM, Metz JR, de Fátima Mazon A, Kemenade BM, Flik G. PMID: 17535873.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    38. Central and peripheral interleukin-1beta and interleukin-1 receptor I expression and their role in the acute stress response of common carp, Cyprinus carpio L. J Endocrinol. 2006 Oct; 191(1):25-35. Metz JR, Huising MO, Leon K, Verburg-van Kemenade BM, Flik G. PMID: 17065386.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    39. Endurance exercise differentially stimulates heart and axial muscle development in zebrafish (Danio rerio). . 2006 Oct; 291(4):R1040-8. van der Meulen T, Schipper H, van den Boogaart JG, Huising MO, Kranenbarg S, van Leeuwen JL. PMID: 16966387.
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    40. Increased leptin expression in common Carp (Cyprinus carpio) after food intake but not after fasting or feeding to satiation. Endocrinology. 2006 Dec; 147(12):5786-97. Huising MO, Geven EJ, Kruiswijk CP, Nabuurs SB, Stolte EH, Spanings FA, Verburg-van Kemenade BM, Flik G. PMID: 16935838.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    41. Real-time gene expression analysis in carp (Cyprinus carpio L.) skin: inflammatory responses to injury mimicking infection with ectoparasites. Dev Comp Immunol. 2007; 31(3):244-54. Gonzalez SF, Huising MO, Stakauskas R, Forlenza M, Lidy Verburg-van Kemenade BM, Buchmann K, Nielsen ME, Wiegertjes GF. PMID: 17034853.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    42. Phylogeny and evolution of class-I helical cytokines. J Endocrinol. 2006 Apr; 189(1):1-25. Huising MO, Kruiswijk CP, Flik G. PMID: 16614377.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    43. The first appearance of Rodlet cells in carp (Cyprinus carpio L.) ontogeny and their possible roles during stress and parasite infection. Fish Shellfish Immunol. 2007 Jan-Feb; 22(1-2):27-37. Mazon AF, Huising MO, Taverne-Thiele AJ, Bastiaans J, Verburg-van Kemenade BM. PMID: 16843681.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    44. The presence of multiple and differentially regulated interleukin-12p40 genes in bony fishes signifies an expansion of the vertebrate heterodimeric cytokine family. Mol Immunol. 2006 Apr; 43(10):1519-33. Huising MO, van Schijndel JE, Kruiswijk CP, Nabuurs SB, Savelkoul HF, Flik G, Verburg-van Kemenade BM. PMID: 16460805.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    45. Corticotropin-releasing hormone-receptor 1 (CRH-R1) and CRH-binding protein (CRH-BP) are expressed in the gills and skin of common carp Cyprinus carpio L. and respond to acute stress and infection. J Exp Biol. 2006 Feb; 209(Pt 3):510-7. Mazon AF, Verburg-van Kemenade BM, Flik G, Huising MO. PMID: 16424101.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    46. CRF and stress in fish. Gen Comp Endocrinol. 2006 Mar; 146(1):36-44. Flik G, Klaren PH, Van den Burg EH, Metz JR, Huising MO. PMID: 16403502.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    47. Multiple and highly divergent IL-11 genes in teleost fish. Immunogenetics. 2005 Jul; 57(6):432-43. Huising MO, Kruiswijk CP, van Schijndel JE, Savelkoul HF, Flik G, Verburg-van Kemenade BM. PMID: 16003467.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    48. Regulation of the stress response in early vertebrates. Ann N Y Acad Sci. 2005 Apr; 1040:345-7. Huising MO, Metz JR, De Mazon AF, Verburg-van Kemenade BM, Flik G. PMID: 15891057.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    49. The remarkable conservation of corticotropin-releasing hormone (CRH)-binding protein in the honeybee (Apis mellifera) dates the CRH system to a common ancestor of insects and vertebrates. Endocrinology. 2005 May; 146(5):2165-70. Huising MO, Flik G. PMID: 15718273.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    50. Rag expression identifies B and T cell lymphopoietic tissues during the development of common carp (Cyprinus carpio). Dev Comp Immunol. 2005; 29(12):1033-47. Huttenhuis HB, Huising MO, van der Meulen T, van Oosterhoud CN, Sánchez NA, Taverne-Thiele AJ, Stroband HW, Rombout JH. PMID: 15967501.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    51. Overproduction of corticotropin-releasing hormone blocks germinal center formation: role of corticosterone and impaired follicular dendritic cell networks. J Neuroimmunol. 2004 Nov; 156(1-2):31-41. Murray SE, Rosenzweig HL, Johnson M, Huising MO, Sawicki K, Stenzel-Poore MP. PMID: 15465594.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    52. Three novel carp CXC chemokines are expressed early in ontogeny and at nonimmune sites. Eur J Biochem. 2004 Oct; 271(20):4094-106. Huising MO, van der Meulen T, Flik G, Verburg-van Kemenade BM. PMID: 15479238.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    53. Localization, expression and control of adrenocorticotropic hormone in the nucleus preopticus and pituitary gland of common carp (Cyprinus carpio L.). J Endocrinol. 2004 Jul; 182(1):23-31. Metz JR, Huising MO, Meek J, Taverne-Thiele AJ, Wendelaar Bonga SE, Flik G. PMID: 15225128.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    54. Structural characterisation of a cyprinid (Cyprinus carpio L.) CRH, CRH-BP and CRH-R1, and the role of these proteins in the acute stress response. J Mol Endocrinol. 2004 Jun; 32(3):627-48. Huising MO, Metz JR, van Schooten C, Taverne-Thiele AJ, Hermsen T, Verburg-van Kemenade BM, Flik G. PMID: 15171705.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    55. The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish. Dev Comp Immunol. 2004 May 03; 28(5):395-413. Huising MO, Stet RJ, Savelkoul HF, Verburg-van Kemenade BM. PMID: 15062640.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    56. CXC chemokines and leukocyte chemotaxis in common carp (Cyprinus carpio L.). Dev Comp Immunol. 2003 Dec; 27(10):875-88. Huising MO, Stolte E, Flik G, Savelkoul HF, Verburg-van Kemenade BM. PMID: 12880637.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    57. Increased efficacy of immersion vaccination in fish with hyperosmotic pretreatment. Vaccine. 2003 Oct 01; 21(27-30):4178-93. Huising MO, Guichelaar T, Hoek C, Verburg-van Kemenade BM, Flik G, Savelkoul HF, Rombout JH. PMID: 14505897.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    58. Molecular evolution of CXC chemokines: extant CXC chemokines originate from the CNS. Trends Immunol. 2003 Jun; 24(6):307-13. Huising MO, Stet RJ, Kruiswijk CP, Savelkoul HF, Lidy Verburg-van Kemenade BM. PMID: 12810106.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    59. Neuroendocrine-immune interactions in fish: a role for interleukin-1. Vet Immunol Immunopathol. 2002 Sep 10; 87(3-4):467-79. Engelsma MY, Huising MO, van Muiswinkel WB, Flik G, Kwang J, Savelkoul HF, Verburg-van Kemenade BM. PMID: 12072274.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    60. Drinking in (very young) fish. Symp Soc Exp Biol. 2002; (54):31-47. Flik G, Varsamos S, Guerreiro PM, Fuentes X, Huising MO, Fenwick JC. PMID: 14992143.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
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