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Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry. Nature. 2025 Jul 30.
Paul D, Bolhuis DL, Yan H, Das S, Xu X, Abbate CC, Jenkins LMM, Emanuele MJ, Andresson T, Huang J, Albeck JG, Brown NG, Cappell SD. PMID: 40739344.
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PubMed Mentions:
1 Fields:
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Deciphering the history of ERK activity from fixed-cell immunofluorescence measurements. Nat Commun. 2025 May 21; 16(1):4721.
Ram A, Pargett M, Choi Y, Murphy D, Teragawa C, Cabel M, Kosaisawe N, Quon G, Albeck JG. PMID: 40399273; PMCID: PMC12095524.
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Translation:
HumansCells
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Spatiotemporal Clusters of Extracellular Signal-Regulated Kinase Activity Coordinate Cytokine-induced Inflammatory Responses in Human Airway Epithelial Cells. Am J Respir Cell Mol Biol. 2025 May; 72(5):520-532.
DeCuzzi NL, Oberbauer D, Chmiel KJ, Pargett M, Ferguson JM, Murphy D, Hardy M, Ram A, Zeki AA, Albeck JG. PMID: 39556370; PMCID: PMC12051922.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Identification of signaling networks associated with lactate modulation of macrophages and dendritic cells. Heliyon. 2025 Feb 15; 11(3):e42098.
Sangsuwan R, Thuamsang B, Pacifici N, Tachachartvanich P, Murphy D, Ram A, Albeck J, Lewis JS. PMID: 39975831; PMCID: PMC11835580.
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PubMed Mentions:
2
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Monitoring Cellular Energy Balance in Single Cells Using Fluorescent Biosensors for AMPK. Methods Mol Biol. 2025; 2882:47-79.
DeCuzzi N, Kosaisawe N, Pargett M, Cabel M, Albeck JG. PMID: 39992504.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Two Novel Red-FRET ERK Biosensors in the 670-720nm Range. bioRxiv. 2024 Dec 02.
DeCuzzi NL, Hu JY, Xu F, Rodriguez B, Pargett M, Albeck JG. PMID: 39677763; PMCID: PMC11642818.
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PubMed Mentions:
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Understanding metabolic plasticity at single cell resolution. Essays Biochem. 2024 Nov 18; 68(3):273-281.
Abbate CC, Hu J, Albeck JG. PMID: 39462995; PMCID: PMC11576188.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Influenza A defective viral genomes and non-infectious particles are increased by host PI3K inhibition via anti-cancer drug alpelisib. bioRxiv. 2024 Jul 03.
Agu I, José I, Ram A, Oberbauer D, Albeck J, Díaz Muñoz SL. PMID: 39005364; PMCID: PMC11245024.
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Editorial: Self-organizing and excitable signaling networks in cell biology. Front Cell Dev Biol. 2024; 12:1430911.
Huang CH, Albeck JG, Devreotes PN. PMID: 38895156; PMCID: PMC11184134.
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Spatiotemporal Clusters of ERK Activity Coordinate Cytokine-induced Inflammatory Responses in Human Airway Epithelial Cells. bioRxiv. 2024 Apr 01.
DeCuzzi NL, Oberbauer DP, Chmiel KJ, Pargett M, Ferguson JM, Murphy D, Zeki AA, Albeck JG. PMID: 38352523; PMCID: PMC10862831.
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PubMed Mentions:
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Deciphering the History of ERK Activity from Fixed-Cell Immunofluorescence Measurements. bioRxiv. 2024 Feb 17.
Ram A, Pargett M, Choi Y, Murphy D, Cabel M, Kosaisawe N, Quon G, Albeck J. PMID: 38405841; PMCID: PMC10889026.
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PubMed Mentions:
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Applications of Plant-Made Fibroblast Growth Factor for Human Pluripotent Stem Cells. Stem Cells Dev. 2024 Feb; 33(3-4):57-66.
Jia J, Wilson W, Karmaker A, Nishimura A, Otsuka H, Ohara K, Okawa H, McDonald K, Nandi S, Albeck JG, Rodriguez R, Zhou P, Nolta JA. PMID: 38062993.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Modeling elucidates context dependence in adipose regulation. Cell Syst. 2023 12 20; 14(12):1021-1023.
Vasquez CD, Albeck JG. PMID: 38128481.
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HumansCells
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A guide to ERK dynamics, part 1: mechanisms and models. Biochem J. 2023 12 13; 480(23):1887-1907.
Ram A, Murphy D, DeCuzzi N, Patankar M, Hu J, Pargett M, Albeck JG. PMID: 38038974; PMCID: PMC10754288.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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A guide to ERK dynamics, part 2: downstream decoding. Biochem J. 2023 12 13; 480(23):1909-1928.
Ram A, Murphy D, DeCuzzi N, Patankar M, Hu J, Pargett M, Albeck JG. PMID: 38038975; PMCID: PMC10754290.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis. Elife. 2023 09 12; 12.
Sparta B, Kosaisawe N, Pargett M, Patankar M, DeCuzzi N, Albeck JG. PMID: 37698461; PMCID: PMC10547473.
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PubMed Mentions:
7 Fields:
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Cellular transformation promotes the incorporation of docosahexaenoic acid into the endolysosome-specific lipid bis(monoacylglycerol)phosphate in breast cancer. Cancer Lett. 2023 03 31; 557:216090.
Berg AL, Showalter MR, Kosaisawe N, Hu M, Stephens NC, Sa M, Heil H, Castro N, Chen JJ, VanderVorst K, Wheeler MR, Rabow Z, Cajka T, Albeck J, Fiehn O, Carraway KL. PMID: 36773796; PMCID: PMC10589064.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Protocol for electrical modulation of ERK signaling dynamics in cell lines. STAR Protoc. 2022 12 16; 3(4):101752.
Zhu K, Guo L, Patel P, Albeck J, Qing Q, Losert W, Zhao M. PMID: 36208452; PMCID: PMC9562398.
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Translation:
Cells
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ERK signaling dynamics: Lights, camera, transduction. Dev Cell. 2022 09 26; 57(18):2151-2152.
Ram A, Albeck JG. PMID: 36167056.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate. iScience. 2021 Nov 19; 24(11):103240.
Guo L, Zhu K, Pargett M, Contreras A, Tsai P, Qing Q, Losert W, Albeck J, Zhao M. PMID: 34746704; PMCID: PMC8554532.
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PubMed Mentions:
8
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Temporal coding of ERK signalling in β-cells. Nat Rev Endocrinol. 2021 09; 17(9):517-518.
Huising MO, Albeck JG. PMID: 34168342.
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Translation:
HumansCells
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Entosis is induced by ultraviolet radiation. iScience. 2021 Aug 20; 24(8):102902.
Chen R, Ram A, Albeck JG, Overholtzer M. PMID: 34401679; PMCID: PMC8353511.
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PubMed Mentions:
17
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Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells. Cell Metab. 2021 03 02; 33(3):649-665.e8.
Kosaisawe N, Sparta B, Pargett M, Teragawa CK, Albeck JG. PMID: 33561427; PMCID: PMC8005262.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Combining Microbial Culturing With Mathematical Modeling in an Introductory Course-Based Undergraduate Research Experience. Front Microbiol. 2020; 11:581903.
Furrow RE, Kim HG, Abdelrazek SMR, Dahlhausen K, Yao AI, Eisen JA, Goldman MS, Albeck JG, Facciotti MT. PMID: 33250873; PMCID: PMC7674939.
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Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway. Mol Syst Biol. 2020 10; 16(10):e9518.
Gillies TE, Pargett M, Silva JM, Teragawa CK, McCormick F, Albeck JG. PMID: 33073539; PMCID: PMC7569415.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity. Cell Syst. 2020 08 26; 11(2):161-175.e5.
Davies AE, Pargett M, Siebert S, Gillies TE, Choi Y, Tobin SJ, Ram AR, Murthy V, Juliano C, Quon G, Bissell MJ, Albeck JG. PMID: 32726596; PMCID: PMC7856305.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Correction for Rodriguez-Medina et al., "Draft Genome Sequences of 16 Halophilic Prokaryotes Isolated from Diverse Environments". Microbiol Resour Announc. 2020 Apr 09; 9(15).
Rodriguez-Medina J, Kim HG, Castro J, Contreras CM, Glon CL, Goyal A, Guo BY, Knowles S, Lin JC, McGuiness CL, Sorkin E, Stefani J, Yegireddi SJ, Chaganti S, Cui D, Deck SL, Deokule Y, Douglas H, Kenaston M, O'Brien A, Patterson E, Schoppa N, Vo DT, Tran K, Tran TL, Pérez-Irizarry V, Carrasquillo-Nieves K, Montalvo-Rodriguez R, Yao AI, Albeck JG, Facciotti MT, Nord AS, Furrow RE. PMID: 32273364; PMCID: PMC7380527.
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PubMed Mentions:
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Draft Genome Sequences of 16 Halophilic Prokaryotes Isolated from Diverse Environments. Microbiol Resour Announc. 2020 Feb 20; 9(8).
Rodriguez-Medina J, Kim HG, Castro J, Contreras CM, Glon CL, Goyal A, Guo BY, Knowles S, Lin JC, McGuiness CL, Sorkin E, Stefani J, Yegireddi SJ, Chaganti S, Cui D, Deck SL, Deokule Y, Douglas H, Kenaston M, O'Brien A, Patterson E, Schoppa N, Tran Vo D, Tran K, Tran TL, Pérez-Irizarry V, Carrasquillo-Nieves K, Montalvo-Rodriguez R, Yao AI, Albeck JG, Facciotti MT, Nord AS, Furrow RE. PMID: 32079635; PMCID: PMC7033272.
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PubMed Mentions:
2
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Controlling ERK Activation Dynamics in Mammary Epithelial Cells with Alternating Electric Fields through Microelectrodes. Nano Lett. 2019 10 09; 19(10):7526-7533.
Guo L, Li H, Wang Y, Li Z, Albeck J, Zhao M, Qing Q. PMID: 31487192; PMCID: PMC6786939.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Experimental and engineering approaches to intracellular communication. Essays Biochem. 2018 10 26; 62(4):515-524.
Albeck JG, Pargett M, Davies AE. PMID: 30139878; PMCID: PMC6619420.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Proceedings of the fifth international RASopathies symposium: When development and cancer intersect. Am J Med Genet A. 2018 12; 176(12):2924-2929.
Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick F. PMID: 30302932; PMCID: PMC6312476.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases. Cell Syst. 2018 06 27; 6(6):664-678.e9.
Sampattavanich S, Steiert B, Kramer BA, Gyori BM, Albeck JG, Sorger PK. PMID: 29886111; PMCID: PMC6322215.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Microenvironmental Signals and Biochemical Information Processing: Cooperative Determinants of Intratumoral Plasticity and Heterogeneity. Front Cell Dev Biol. 2018; 6:44.
Davies AE, Albeck JG. PMID: 29732370; PMCID: PMC5921997.
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PubMed Mentions:
26
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Live-Cell Imaging and Analysis with Multiple Genetically Encoded Reporters. Curr Protoc Cell Biol. 2018 03; 78(1):4.36.1-4.36.19.
Pargett M, Albeck JG. PMID: 30040182; PMCID: PMC6060629.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. Elife. 2017 12 14; 6.
Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG. PMID: 29239720; PMCID: PMC5730373.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Linear Integration of ERK Activity Predominates over Persistence Detection in Fra-1 Regulation. Cell Syst. 2017 12 27; 5(6):549-563.e5.
Gillies TE, Pargett M, Minguet M, Davies AE, Albeck JG. PMID: 29199017; PMCID: PMC5746471.
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PubMed Mentions:
56 Fields:
Translation:
HumansAnimalsCells
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Impact of diet-derived signaling molecules on human cognition: exploring the food-brain axis. NPJ Sci Food. 2017; 1:2.
Rodriguez RL, Albeck JG, Taha AY, Ori-McKenney KM, Recanzone GH, Stradleigh TW, Hernandez BC, Tang FV, Chiang EI, Cruz-Orengo L. PMID: 31304244; PMCID: PMC6548416.
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PubMed Mentions:
10
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Entosis Is Induced by Glucose Starvation. Cell Rep. 2017 07 05; 20(1):201-210.
Hamann JC, Surcel A, Chen R, Teragawa C, Albeck JG, Robinson DN, Overholtzer M. PMID: 28683313; PMCID: PMC5559205.
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PubMed Mentions:
97 Fields:
Translation:
HumansCells
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Relaxation oscillations and hierarchy of feedbacks in MAPK signaling. Sci Rep. 2017 01 03; 7:38244.
Kochanczyk M, Kocieniewski P, Kozlowska E, Jaruszewicz-Blonska J, Sparta B, Pargett M, Albeck JG, Hlavacek WS, Lipniacki T. PMID: 28045041; PMCID: PMC5206726.
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PubMed Mentions:
31 Fields:
Translation:
Cells
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Single-Cell Imaging of ERK Signaling Using Fluorescent Biosensors. Methods Mol Biol. 2017; 1636:35-59.
Pargett M, Gillies TE, Teragawa CK, Sparta B, Albeck JG. PMID: 28730471; PMCID: PMC8005261.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Mapping the Spectrum of Gene Expression Responses. Cell Syst. 2016 04 27; 2(4):221-2.
Pargett M, Albeck JG. PMID: 27135533.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton. Cell. 2016 Jan 28; 164(3):433-46.
Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D, Varma G, Hung YP, Ullas S, Lauring J, Seth P, Lundquist MR, Tolan DR, Grant AK, Needleman DJ, Asara JM, Cantley LC, Wulf GM. PMID: 26824656; PMCID: PMC4898774.
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PubMed Mentions:
219 Fields:
Translation:
HumansAnimalsCells
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Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses. J Biol Chem. 2015 Oct 09; 290(41):24784-92.
Sparta B, Pargett M, Minguet M, Distor K, Bell G, Albeck JG. PMID: 26304118; PMCID: PMC4598990.
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PubMed Mentions:
61 Fields:
Translation:
HumansCells
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Systems biology. Accurate information transmission through dynamic biochemical signaling networks. Science. 2014 Dec 12; 346(6215):1370-3.
Selimkhanov J, Taylor B, Yao J, Pilko A, Albeck J, Hoffmann A, Tsimring L, Wollman R. PMID: 25504722; PMCID: PMC4813785.
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PubMed Mentions:
186 Fields:
Translation:
HumansCells
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Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. Elife. 2014 Jul 09; 3.
Shestov AA, Liu X, Ser Z, Cluntun AA, Hung YP, Huang L, Kim D, Le A, Yellen G, Albeck JG, Locasale JW. PMID: 25009227; PMCID: PMC4118620.
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PubMed Mentions:
140 Fields:
Translation:
HumansCells
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Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell. 2013 Jan 24; 49(2):249-61.
Albeck JG, Mills GB, Brugge JS. PMID: 23219535; PMCID: PMC4151532.
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PubMed Mentions:
273 Fields:
Translation:
HumansCells
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Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2. Sci Signal. 2012 Mar 06; 5(214):ra19.
Worster DT, Schmelzle T, Solimini NL, Lightcap ES, Millard B, Mills GB, Brugge JS, Albeck JG. PMID: 22394561; PMCID: PMC4174537.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor. Cell Metab. 2011 Oct 05; 14(4):545-54.
Hung YP, Albeck JG, Tantama M, Yellen G. PMID: 21982714; PMCID: PMC3190165.
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PubMed Mentions:
264 Fields:
Translation:
AnimalsCells
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Asymmetric cancer cell division regulated by AKT. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12845-50.
Dey-Guha I, Wolfer A, Yeh AC, G Albeck J, Darp R, Leon E, Wulfkuhle J, Petricoin EF, Wittner BS, Ramaswamy S. PMID: 21757645; PMCID: PMC3150943.
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PubMed Mentions:
75 Fields:
Translation:
HumansCells
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Uncovering a tumor suppressor for triple-negative breast cancers. Cell. 2011 Mar 04; 144(5):638-40.
Albeck JG, Brugge JS. PMID: 21376226.
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PubMed Mentions:
9 Fields:
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Systematic calibration of a cell signaling network model. BMC Bioinformatics. 2010 Apr 23; 11:202.
Kim KA, Spencer SL, Albeck JG, Burke JM, Sorger PK, Gaudet S, Kim DH. PMID: 20416044; PMCID: PMC2880028.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5012-7.
Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS. PMID: 20194747; PMCID: PMC2841923.
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PubMed Mentions:
103 Fields:
Translation:
HumansCells
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Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature. 2009 May 21; 459(7245):428-32.
Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. PMID: 19363473; PMCID: PMC2858974.
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PubMed Mentions:
544 Fields:
Translation:
HumansCells
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Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol. 2008 Dec 02; 6(12):2831-52.
Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. PMID: 19053173; PMCID: PMC2592357.
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PubMed Mentions:
146 Fields:
Translation:
HumansCells
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Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol Cell. 2008 Apr 11; 30(1):11-25.
Albeck JG, Burke JM, Aldridge BB, Zhang M, Lauffenburger DA, Sorger PK. PMID: 18406323; PMCID: PMC2858979.
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PubMed Mentions:
198 Fields:
Translation:
HumansCells
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Collecting and organizing systematic sets of protein data. Nat Rev Mol Cell Biol. 2006 Nov; 7(11):803-12.
Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S. PMID: 17057751.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell. 2006 Mar 24; 124(6):1225-39.
Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. PMID: 16564013.
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PubMed Mentions:
105 Fields:
Translation:
HumansCells
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A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science. 2005 Dec 09; 310(5754):1646-53.
Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. PMID: 16339439.
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PubMed Mentions:
225 Fields:
Translation:
HumansCells
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A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Mol Cell Proteomics. 2005 Oct; 4(10):1569-90.
Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK. PMID: 16030008.
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PubMed Mentions:
71 Fields:
Translation:
HumansCells
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Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. J Comput Biol. 2004; 11(4):544-61.
Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA. PMID: 15579231.
View in:
PubMed Mentions:
54 Fields:
Translation:
HumansCells
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A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Mol Cell Proteomics. 2003 Jul; 2(7):463-73.
Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. PMID: 12832460.
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PubMed Mentions:
36 Fields:
Translation:
HumansCells
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Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases. J Biol Chem. 2002 Feb 15; 277(7):5644-50.
Feng Q, Albeck JG, Cerione RA, Yang W. PMID: 11741931.
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PubMed Mentions:
49 Fields:
Translation:
AnimalsCells