John Albeck

Title(s)Associate Professor, Molecular and Cellular Biology
SchoolCollege of Biological Sciences
Address243 Briggs Hall
CA 95616
Phone530-752-0646
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    Collapse Research 
    Collapse Research Activities and Funding
    Decoding temporal epithelial signaling programs to restore homeostasis in acute lung injury
    NIH R01HL151983Sep 1, 2021 - Jun 30, 2025
    Role: Principal Investigator
    Control of gene expression by dynamic metabolic oscillations
    NIH R35GM139621Aug 4, 2021 - Jul 31, 2026
    Role: Principal Investigator
    The role of dynamics in defining the limits of normal developmental signaling.
    NIH R01GM115650Aug 1, 2016 - Jun 30, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Spatiotemporal Clusters of ERK Activity Coordinate Cytokine-induced Inflammatory Responses in Human Airway Epithelial Cells. bioRxiv. 2024 Apr 01. DeCuzzi NL, Oberbauer DP, Chmiel KJ, Pargett M, Ferguson JM, Murphy D, Zeki AA, Albeck JG. PMID: 38352523; PMCID: PMC10862831.
      View in: PubMed   Mentions:
    2. Deciphering the History of ERK Activity from Fixed-Cell Immunofluorescence Measurements. bioRxiv. 2024 Feb 17. Ram A, Pargett M, Choi Y, Murphy D, Cabel M, Kosaisawe N, Quon G, Albeck J. PMID: 38405841; PMCID: PMC10889026.
      View in: PubMed   Mentions:
    3. Applications of Plant-Made Fibroblast Growth Factor for Human Pluripotent Stem Cells. Stem Cells Dev. 2024 Feb; 33(3-4):57-66. Jia J, Wilson W, Karmaker A, Nishimura A, Otsuka H, Ohara K, Okawa H, McDonald K, Nandi S, Albeck JG, Rodriguez R, Zhou P, Nolta JA. PMID: 38062993.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Modeling elucidates context dependence in adipose regulation. Cell Syst. 2023 12 20; 14(12):1021-1023. Vasquez CD, Albeck JG. PMID: 38128481.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. A guide to ERK dynamics, part 1: mechanisms and models. Biochem J. 2023 12 13; 480(23):1887-1907. Ram A, Murphy D, DeCuzzi N, Patankar M, Hu J, Pargett M, Albeck JG. PMID: 38038974; PMCID: PMC10754288.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. A guide to ERK dynamics, part 2: downstream decoding. Biochem J. 2023 12 13; 480(23):1909-1928. Ram A, Murphy D, DeCuzzi N, Patankar M, Hu J, Pargett M, Albeck JG. PMID: 38038975; PMCID: PMC10754290.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis. Elife. 2023 09 12; 12. Sparta B, Kosaisawe N, Pargett M, Patankar M, DeCuzzi N, Albeck JG. PMID: 37698461; PMCID: PMC10547473.
      View in: PubMed   Mentions:    Fields:    
    8. Cellular transformation promotes the incorporation of docosahexaenoic acid into the endolysosome-specific lipid bis(monoacylglycerol)phosphate in breast cancer. Cancer Lett. 2023 03 31; 557:216090. Berg AL, Showalter MR, Kosaisawe N, Hu M, Stephens NC, Sa M, Heil H, Castro N, Chen JJ, VanderVorst K, Wheeler MR, Rabow Z, Cajka T, Albeck J, Fiehn O, Carraway KL. PMID: 36773796; PMCID: PMC10589064.
      View in: PubMed   Mentions:    Fields:    
    9. Protocol for electrical modulation of ERK signaling dynamics in cell lines. STAR Protoc. 2022 Oct 06; 3(4):101752. Zhu K, Guo L, Patel P, Albeck J, Qing Q, Losert W, Zhao M. PMID: 36208452; PMCID: PMC9562398.
      View in: PubMed   Mentions:    Fields:    
    10. ERK signaling dynamics: Lights, camera, transduction. Dev Cell. 2022 09 26; 57(18):2151-2152. Ram A, Albeck JG. PMID: 36167056.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    11. Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate. iScience. 2021 Nov 19; 24(11):103240. Guo L, Zhu K, Pargett M, Contreras A, Tsai P, Qing Q, Losert W, Albeck J, Zhao M. PMID: 34746704; PMCID: PMC8554532.
      View in: PubMed   Mentions: 5  
    12. Temporal coding of ERK signalling in β-cells. Nat Rev Endocrinol. 2021 09; 17(9):517-518. Huising MO, Albeck JG. PMID: 34168342.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Entosis is induced by ultraviolet radiation. iScience. 2021 Aug 20; 24(8):102902. Chen R, Ram A, Albeck JG, Overholtzer M. PMID: 34401679; PMCID: PMC8353511.
      View in: PubMed   Mentions: 12  
    14. Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells. Cell Metab. 2021 03 02; 33(3):649-665.e8. Kosaisawe N, Sparta B, Pargett M, Teragawa CK, Albeck JG. PMID: 33561427; PMCID: PMC8005262.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    15. Combining Microbial Culturing With Mathematical Modeling in an Introductory Course-Based Undergraduate Research Experience. Front Microbiol. 2020; 11:581903. Furrow RE, Kim HG, Abdelrazek SMR, Dahlhausen K, Yao AI, Eisen JA, Goldman MS, Albeck JG, Facciotti MT. PMID: 33250873; PMCID: PMC7674939.
      View in: PubMed   Mentions:
    16. Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway. Mol Syst Biol. 2020 10; 16(10):e9518. Gillies TE, Pargett M, Silva JM, Teragawa CK, McCormick F, Albeck JG. PMID: 33073539; PMCID: PMC7569415.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    17. Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity. Cell Syst. 2020 08 26; 11(2):161-175.e5. Davies AE, Pargett M, Siebert S, Gillies TE, Choi Y, Tobin SJ, Ram AR, Murthy V, Juliano C, Quon G, Bissell MJ, Albeck JG. PMID: 32726596; PMCID: PMC7856305.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    18. Correction for Rodriguez-Medina et al., "Draft Genome Sequences of 16 Halophilic Prokaryotes Isolated from Diverse Environments". Microbiol Resour Announc. 2020 Apr 09; 9(15). Rodriguez-Medina J, Kim HG, Castro J, Contreras CM, Glon CL, Goyal A, Guo BY, Knowles S, Lin JC, McGuiness CL, Sorkin E, Stefani J, Yegireddi SJ, Chaganti S, Cui D, Deck SL, Deokule Y, Douglas H, Kenaston M, O'Brien A, Patterson E, Schoppa N, Vo DT, Tran K, Tran TL, Pérez-Irizarry V, Carrasquillo-Nieves K, Montalvo-Rodriguez R, Yao AI, Albeck JG, Facciotti MT, Nord AS, Furrow RE. PMID: 32273364; PMCID: PMC7380527.
      View in: PubMed   Mentions:
    19. Draft Genome Sequences of 16 Halophilic Prokaryotes Isolated from Diverse Environments. Microbiol Resour Announc. 2020 Feb 20; 9(8). Rodriguez-Medina J, Kim HG, Castro J, Contreras CM, Glon CL, Goyal A, Guo BY, Knowles S, Lin JC, McGuiness CL, Sorkin E, Stefani J, Yegireddi SJ, Chaganti S, Cui D, Deck SL, Deokule Y, Douglas H, Kenaston M, O'Brien A, Patterson E, Schoppa N, Tran Vo D, Tran K, Tran TL, Pérez-Irizarry V, Carrasquillo-Nieves K, Montalvo-Rodriguez R, Yao AI, Albeck JG, Facciotti MT, Nord AS, Furrow RE. PMID: 32079635; PMCID: PMC7033272.
      View in: PubMed   Mentions: 2  
    20. Controlling ERK Activation Dynamics in Mammary Epithelial Cells with Alternating Electric Fields through Microelectrodes. Nano Lett. 2019 10 09; 19(10):7526-7533. Guo L, Li H, Wang Y, Li Z, Albeck J, Zhao M, Qing Q. PMID: 31487192; PMCID: PMC6786939.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    21. Experimental and engineering approaches to intracellular communication. Essays Biochem. 2018 10 26; 62(4):515-524. Albeck JG, Pargett M, Davies AE. PMID: 30139878; PMCID: PMC6619420.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    22. Proceedings of the fifth international RASopathies symposium: When development and cancer intersect. Am J Med Genet A. 2018 12; 176(12):2924-2929. Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick F. PMID: 30302932; PMCID: PMC6312476.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    23. Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases. Cell Syst. 2018 06 27; 6(6):664-678.e9. Sampattavanich S, Steiert B, Kramer BA, Gyori BM, Albeck JG, Sorger PK. PMID: 29886111; PMCID: PMC6322215.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    24. Microenvironmental Signals and Biochemical Information Processing: Cooperative Determinants of Intratumoral Plasticity and Heterogeneity. Front Cell Dev Biol. 2018; 6:44. Davies AE, Albeck JG. PMID: 29732370; PMCID: PMC5921997.
      View in: PubMed   Mentions: 22  
    25. Live-Cell Imaging and Analysis with Multiple Genetically Encoded Reporters. Curr Protoc Cell Biol. 2018 03; 78(1):4.36.1-4.36.19. Pargett M, Albeck JG. PMID: 30040182; PMCID: PMC6060629.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    26. Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. Elife. 2017 12 14; 6. Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG. PMID: 29239720; PMCID: PMC5730373.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    27. Linear Integration of ERK Activity Predominates over Persistence Detection in Fra-1 Regulation. Cell Syst. 2017 12 27; 5(6):549-563.e5. Gillies TE, Pargett M, Minguet M, Davies AE, Albeck JG. PMID: 29199017; PMCID: PMC5746471.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    28. Impact of diet-derived signaling molecules on human cognition: exploring the food-brain axis. NPJ Sci Food. 2017; 1:2. Rodriguez RL, Albeck JG, Taha AY, Ori-McKenney KM, Recanzone GH, Stradleigh TW, Hernandez BC, Tang FV, Chiang EI, Cruz-Orengo L. PMID: 31304244; PMCID: PMC6548416.
      View in: PubMed   Mentions: 8  
    29. Entosis Is Induced by Glucose Starvation. Cell Rep. 2017 07 05; 20(1):201-210. Hamann JC, Surcel A, Chen R, Teragawa C, Albeck JG, Robinson DN, Overholtzer M. PMID: 28683313; PMCID: PMC5559205.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    30. Relaxation oscillations and hierarchy of feedbacks in MAPK signaling. Sci Rep. 2017 01 03; 7:38244. Kochanczyk M, Kocieniewski P, Kozlowska E, Jaruszewicz-Blonska J, Sparta B, Pargett M, Albeck JG, Hlavacek WS, Lipniacki T. PMID: 28045041; PMCID: PMC5206726.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    31. Single-Cell Imaging of ERK Signaling Using Fluorescent Biosensors. Methods Mol Biol. 2017; 1636:35-59. Pargett M, Gillies TE, Teragawa CK, Sparta B, Albeck JG. PMID: 28730471; PMCID: PMC8005261.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    32. Mapping the Spectrum of Gene Expression Responses. Cell Syst. 2016 04 27; 2(4):221-2. Pargett M, Albeck JG. PMID: 27135533.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    33. Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton. Cell. 2016 Jan 28; 164(3):433-46. Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D, Varma G, Hung YP, Ullas S, Lauring J, Seth P, Lundquist MR, Tolan DR, Grant AK, Needleman DJ, Asara JM, Cantley LC, Wulf GM. PMID: 26824656; PMCID: PMC4898774.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimalsCells
    34. Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses. J Biol Chem. 2015 Oct 09; 290(41):24784-92. Sparta B, Pargett M, Minguet M, Distor K, Bell G, Albeck JG. PMID: 26304118; PMCID: PMC4598990.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    35. Systems biology. Accurate information transmission through dynamic biochemical signaling networks. Science. 2014 Dec 12; 346(6215):1370-3. Selimkhanov J, Taylor B, Yao J, Pilko A, Albeck J, Hoffmann A, Tsimring L, Wollman R. PMID: 25504722; PMCID: PMC4813785.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansCells
    36. Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. Elife. 2014 Jul 09; 3. Shestov AA, Liu X, Ser Z, Cluntun AA, Hung YP, Huang L, Kim D, Le A, Yellen G, Albeck JG, Locasale JW. PMID: 25009227; PMCID: PMC4118620.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    37. Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell. 2013 Jan 24; 49(2):249-61. Albeck JG, Mills GB, Brugge JS. PMID: 23219535; PMCID: PMC4151532.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansCells
    38. Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2. Sci Signal. 2012 Mar 06; 5(214):ra19. Worster DT, Schmelzle T, Solimini NL, Lightcap ES, Millard B, Mills GB, Brugge JS, Albeck JG. PMID: 22394561; PMCID: PMC4174537.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    39. Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor. Cell Metab. 2011 Oct 05; 14(4):545-54. Hung YP, Albeck JG, Tantama M, Yellen G. PMID: 21982714; PMCID: PMC3190165.
      View in: PubMed   Mentions: 240     Fields:    Translation:AnimalsCells
    40. Asymmetric cancer cell division regulated by AKT. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12845-50. Dey-Guha I, Wolfer A, Yeh AC, G Albeck J, Darp R, Leon E, Wulfkuhle J, Petricoin EF, Wittner BS, Ramaswamy S. PMID: 21757645; PMCID: PMC3150943.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    41. Uncovering a tumor suppressor for triple-negative breast cancers. Cell. 2011 Mar 04; 144(5):638-40. Albeck JG, Brugge JS. PMID: 21376226.
      View in: PubMed   Mentions: 9     Fields:    
    42. Systematic calibration of a cell signaling network model. BMC Bioinformatics. 2010 Apr 23; 11:202. Kim KA, Spencer SL, Albeck JG, Burke JM, Sorger PK, Gaudet S, Kim DH. PMID: 20416044; PMCID: PMC2880028.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    43. Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5012-7. Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS. PMID: 20194747; PMCID: PMC2841923.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    44. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature. 2009 May 21; 459(7245):428-32. Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. PMID: 19363473; PMCID: PMC2858974.
      View in: PubMed   Mentions: 513     Fields:    Translation:HumansCells
    45. Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol. 2008 Dec 02; 6(12):2831-52. Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. PMID: 19053173; PMCID: PMC2592357.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansCells
    46. Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol Cell. 2008 Apr 11; 30(1):11-25. Albeck JG, Burke JM, Aldridge BB, Zhang M, Lauffenburger DA, Sorger PK. PMID: 18406323; PMCID: PMC2858979.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansCells
    47. Collecting and organizing systematic sets of protein data. Nat Rev Mol Cell Biol. 2006 Nov; 7(11):803-12. Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S. PMID: 17057751.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    48. The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell. 2006 Mar 24; 124(6):1225-39. Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. PMID: 16564013.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    49. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science. 2005 Dec 09; 310(5754):1646-53. Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. PMID: 16339439.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansCells
    50. A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Mol Cell Proteomics. 2005 Oct; 4(10):1569-90. Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK. PMID: 16030008.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    51. Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. J Comput Biol. 2004; 11(4):544-61. Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA. PMID: 15579231.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    52. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Mol Cell Proteomics. 2003 Jul; 2(7):463-73. Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. PMID: 12832460.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    53. Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases. J Biol Chem. 2002 Feb 15; 277(7):5644-50. Feng Q, Albeck JG, Cerione RA, Yang W. PMID: 11741931.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
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