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A role for heavy chain-modification in protecting hyaluronan from free radical fragmentation during inflammation. bioRxiv. 2026 Jan 12.
Poddar S, Erxleben DA, Dodd RJ, Reesink HL, Green DE, DeAngelis PL, Day AJ, Hall AR. PMID: 41648319; PMCID: PMC12871184.
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Lectin Microarray-based Glycomics and Machine Learning Identify Shared Osteoarthritis Biomarkers in Humans, Dogs, and Horses. bioRxiv. 2025 Oct 17.
Peralta AG, Raeisimakiani P, Hayashi K, Mahal LK, Reesink HL. PMID: 41279656; PMCID: PMC12632833.
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Proteoglycan 4 is expressed in equine flexor tendons and tendon sheaths, with greater synovial fluid lubricin in tendon sheaths with tendon injury. Am J Vet Res. 2025 Dec 01; 86(12).
Woodman MJ, Thomas MA, Colville MJ, Durgam S, McDonough SP, Reesink HL. PMID: 41038243.
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Translation:
Animals
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Delayed Lubricin Injection Improves Cartilage Repair Tissue Quality in an In Vivo Rabbit Osteochondral Defect Model. J Orthop Res. 2025 Dec; 43(12):2125-2135.
Yoon D, Vishwanath K, Dankert J, Butler JJ, Azam MT, Gianakos AL, Colville MJ, Lopez SG, Paszek MJ, Reesink HL, Kennedy JG, Bonassar LJ, Irwin RM. PMID: 40946210; PMCID: PMC12917763.
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Translation:
Animals
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Multiscale characterization of ultrasmall fluorescent core-shell silica nanoparticles in cartilage and synovial joints reveals rapid cartilage penetration and sustained joint residence. Acta Biomater. 2025 Jun 15; 200:313-325.
Fortin AG, Naguib N, Secor EJ, Reesink HL, Wiesner UB, Bonassar LJ. PMID: 40349899; PMCID: PMC12539274.
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Translation:
HumansAnimalsCells
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Synovial fluid alpha-2-macroglobulin, gelsolin and lubricin distinguish between osteoarthritic and healthy equine joints. Equine Vet J. 2026 Jan; 58(1):49-59.
Secor EJ, Womack SJ, Ysebaert MP, Colville MJ, Reesink HL. PMID: 40342270; PMCID: PMC12409676.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Proteomics Reveals Increased Periostin in Synovial Fluid From Canine and Human Anterior Cruciate Ligament Injury. J Orthop Res. 2025 Jul; 43(7):1239-1249.
Womack SJ, Carballo CB, Secor EJ, Rodeo SA, Reesink HL. PMID: 40247443; PMCID: PMC12159583.
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2 Fields:
Translation:
HumansAnimals
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Editorial: Sports medicine and physical rehabilitation, volume III. Front Vet Sci. 2025; 12:1551208.
Levine D, Pechette Markley A, Marcellin-Little DJ, Reesink H. PMID: 40046419; PMCID: PMC11880228.
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Delayed lubricin injection improves cartilage repair tissue quality in an in vivo rabbit osteochondral defect model. bioRxiv. 2025 Feb 08.
Yoon D, Vishwanath K, Dankert J, Butler JJ, Azam MT, Gianakos AL, Colville MJ, Lopez SG, Paszek MJ, Reesink HL, Kennedy JG, Bonassar LJ, Irwin RM. PMID: 39974965; PMCID: PMC11839081.
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PubMed Mentions:
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Leucine zipper-based SAIM imaging identifies therapeutic agents to disrupt the cancer cell glycocalyx for enhanced immunotherapy. bioRxiv. 2024 Dec 06.
Park S, Paek JH, Colville MJ, Huang LT, Struzyk AP, Womack SJ, Neelamegham S, Reesink HL, Paszek MJ. PMID: 39677754; PMCID: PMC11643053.
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Bioengineered lubricin alters the lubrication modes of cartilage in a dose-dependent manner. J Orthop Res. 2025 Mar; 43(3):531-540.
Vishwanath K, Su J, Colville MJ, Paszek M, Reesink HL, Bonassar LJ. PMID: 39521731.
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Translation:
Animals
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Specific Degradation of the Mucin Domain of Lubricin in Synovial Fluid Impairs Cartilage Lubrication. ACS Biomater Sci Eng. 2024 11 11; 10(11):6915-6926.
Prajapati M, Vishwanath K, Huang L, Colville M, Reesink H, Paszek M, Bonassar LJ. PMID: 39425698.
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Translation:
HumansAnimalsCells
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Mineralization of equine proximal sesamoid bones precedes articular cartilage and fibrocartilaginous enthesis maturation in early postgestational development. Am J Vet Res. 2024 Oct 01; 85(10).
Okudaira M, Cresswell EN, Wollman CW, McDonough SP, Engiles JB, Reesink HL. PMID: 39084240.
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Translation:
Animals
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Recombinant manufacturing of multispecies biolubricants. bioRxiv. 2024 May 05.
Colville MJ, Huang LT, Schmidt S, Chen K, Vishwanath K, Su J, Williams RM, Bonassar LJ, Reesink HL, Paszek MJ. PMID: 38746339; PMCID: PMC11092771.
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Immunoengineering can overcome the glycocalyx armour of cancer cells. Nat Mater. 2024 Mar; 23(3):429-438.
Park S, Colville MJ, Paek JH, Shurer CR, Singh A, Secor EJ, Sailer CJ, Huang LT, Kuo JC, Goudge MC, Su J, Kim M, DeLisa MP, Neelamegham S, Lammerding J, Zipfel WR, Fischbach C, Reesink HL, Paszek MJ. PMID: 38361041; PMCID: PMC11471287.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Loss of effective lubricating viscosity is the primary mechanical marker of joint inflammation in equine synovitis. J Orthop Res. 2024 07; 42(7):1438-1447.
Vishwanath K, Secor EJ, Watkins A, Reesink HL, Bonassar LJ. PMID: 38291343; PMCID: PMC12766795.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Equine synovial sepsis laboratory submissions yield a low rate of positive bacterial culture and a high prevalence of antimicrobial resistance. Am J Vet Res. 2023 Aug 01; 84(8).
Pearson GB, Papa B, Mosaddegh A, Cooper H, Aprea M, Pigott J, Altier C, Cazer CL, Reesink HL. PMID: 37460096.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Metacarpophalangeal Joint Pathology and Bone Mineral Density Increase with Exercise but Not with Incidence of Proximal Sesamoid Bone Fracture in Thoroughbred Racehorses. Animals (Basel). 2023 Feb 24; 13(5).
Noordwijk KJ, Chen L, Ruspi BD, Schurer S, Papa B, Fasanello DC, McDonough SP, Palmer SE, Porter IR, Basran PS, Donnelly E, Reesink HL. PMID: 36899684; PMCID: PMC10000193.
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PubMed Mentions:
3
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Recombinant mucin biotechnology and engineering. Adv Drug Deliv Rev. 2023 Feb; 193:114618.
Park S, Chin-Hun Kuo J, Reesink HL, Paszek MJ. PMID: 36375719; PMCID: PMC10253230.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Radiomics Modeling of Catastrophic Proximal Sesamoid Bone Fractures in Thoroughbred Racehorses Using μCT. Animals (Basel). 2022 Nov 04; 12(21).
Basran PS, McDonough S, Palmer S, Reesink HL. PMID: 36359157; PMCID: PMC9658779.
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Proximal sesamoid bone microdamage is localized to articular subchondral regions in Thoroughbred racehorses, with similar fracture toughness between fracture and controls. Vet Surg. 2022 Aug; 51(6):952-962.
Luedke LK, Ilevbare P, Noordwijk KJ, Palomino PM, McDonough SP, Palmer SE, Basran PS, Donnelly E, Reesink HL. PMID: 35672916.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Assessment of osteoarthritis functional outcomes and intra-articular injection volume in the rat anterior cruciate ligament transection model. J Orthop Res. 2022 09; 40(9):2004-2014.
Wang Y, Wagner ES, Yu D, Chen KJ, Keel TJ, Pownder SL, Koff MF, Cheetham J, Samaroo KJ, Reesink HL. PMID: 34994469; PMCID: PMC9259760.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Intra-Articular Administration of a Synthetic Lubricin in Canine Stifles. Vet Comp Orthop Traumatol. 2022 Mar; 35(2):90-95.
Hayashi K, Bourgeois A, Lopez D, Caserto BG, Berthelsen E, Krotscheck U, Reesink HL, Kim SY, Putnam D. PMID: 34598303.
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Translation:
Animals
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Hyaluronic acid synthesis, degradation, and crosslinking in equine osteoarthritis: TNF-α-TSG-6-mediated HC-HA formation. Arthritis Res Ther. 2021 08 20; 23(1):218.
Fasanello DC, Su J, Deng S, Yin R, Colville MJ, Berenson JM, Kelly CM, Freer H, Rollins A, Wagner B, Rivas F, Hall AR, Rahbar E, DeAngelis PL, Paszek MJ, Reesink HL. PMID: 34416923; PMCID: PMC8377964.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Surgical treatment of uterine neoplasia in 13 production size pigs with a comparison to pot-bellied pigs. Vet Surg. 2021 Oct; 50(7):1434-1442.
McOnie RC, Noel AM, Fubini SL, Reesink HL. PMID: 34347882.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Investigation of synovial fluid lubricants and inflammatory cytokines in the horse: a comparison of recombinant equine interleukin 1 beta-induced synovitis and joint lavage models. BMC Vet Res. 2021 May 12; 17(1):189.
Watkins A, Fasanello D, Stefanovski D, Schurer S, Caracappa K, D'Agostino A, Costello E, Freer H, Rollins A, Read C, Su J, Colville M, Paszek M, Wagner B, Reesink H. PMID: 33980227; PMCID: PMC8117281.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Metabolism and global protein glycosylation are differentially expressed in healthy and osteoarthritic equine carpal synovial fluid. Equine Vet J. 2022 Mar; 54(2):323-333.
Noordwijk KJ, Qin R, Diaz-Rubio ME, Zhang S, Su J, Mahal LK, Reesink HL. PMID: 33587757; PMCID: PMC8364562.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Synovial fluid lubricin increases in spontaneous canine cruciate ligament rupture. Sci Rep. 2020 10 07; 10(1):16725.
Wang Y, Gludish DW, Hayashi K, Todhunter RJ, Krotscheck U, Johnson PJ, Cummings BP, Su J, Reesink HL. PMID: 33028842; PMCID: PMC7542452.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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A radiomics platform for computing imaging features from µCT images of Thoroughbred racehorse proximal sesamoid bones: Benchmark performance and evaluation. Equine Vet J. 2021 Mar; 53(2):277-286.
Basran PS, Gao J, Palmer S, Reesink HL. PMID: 32654167.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Lubricin in experimental and naturally occurring osteoarthritis: a systematic review. Osteoarthritis Cartilage. 2020 10; 28(10):1303-1315.
Watkins AR, Reesink HL. PMID: 32504786; PMCID: PMC8043104.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimals
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The surface stress of biomedical silicones is a stimulant of cellular response. Sci Adv. 2020 04; 6(15):eaay0076.
Cheng Z, Shurer CR, Schmidt S, Gupta VK, Chuang G, Su J, Watkins AR, Shetty A, Spector JA, Hui CY, Reesink HL, Paszek MJ. PMID: 32300645; PMCID: PMC7148089.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Synovial fluid lubricin and hyaluronan are altered in equine osteochondral fragmentation, cartilage impact injury, and full-thickness cartilage defect models. J Orthop Res. 2020 08; 38(8):1826-1835.
Peal BT, Gagliardi R, Su J, Fortier LA, Delco ML, Nixon AJ, Reesink HL. PMID: 31965593; PMCID: PMC7354223.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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Rhodococcus equi Joint Sepsis and Osteomyelitis Is Associated With a Grave Prognosis in Foals. Front Vet Sci. 2019; 6:503.
Ruocco NA, Luedke LK, Fortier LA, Ducharme NG, Reesink HL. PMID: 31993449; PMCID: PMC6971166.
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PubMed Mentions:
2
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Physical Principles of Membrane Shape Regulation by the Glycocalyx. Cell. 2019 06 13; 177(7):1757-1770.e21.
Shurer CR, Kuo JC, Roberts LM, Gandhi JG, Colville MJ, Enoki TA, Pan H, Su J, Noble JM, Hollander MJ, O'Donnell JP, Yin R, Pedram K, Möckl L, Kourkoutis LF, Moerner WE, Bertozzi CR, Feigenson GW, Reesink HL, Paszek MJ. PMID: 31056282; PMCID: PMC6768631.
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PubMed Mentions:
140 Fields:
Translation:
HumansAnimalsCells
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Temporal changes in synovial fluid composition and elastoviscous lubrication in the equine carpal fracture model. J Orthop Res. 2019 05; 37(5):1071-1079.
Feeney E, Peal BT, Inglis JE, Su J, Nixon AJ, Bonassar LJ, Reesink HL. PMID: 30859611; PMCID: PMC6768400.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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Return to racing after surgical management of third carpal bone slab fractures in thoroughbred and standardbred racehorses. Vet Surg. 2019 May; 48(4):513-523.
Doering AK, Reesink HL, Luedke LK, Moore C, Nixon AJ, Fortier LA, Ducharme NG, Ross MW, Levine DG, Richardson DW, Stefanovski D, Ortved KF. PMID: 30883815.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Stable recombinant production of codon-scrambled lubricin and mucin in human cells. Biotechnol Bioeng. 2019 06; 116(6):1292-1303.
Shurer CR, Wang Y, Feeney E, Head SE, Zhang VX, Su J, Cheng Z, Stark MA, Bonassar LJ, Reesink HL, Paszek MJ. PMID: 30684357; PMCID: PMC6764099.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Galectins-1 and-3 Increase in Equine Post-traumatic Osteoarthritis. Front Vet Sci. 2018; 5:288.
Reesink HL, Nixon AJ, Su J, Liu S, Sutton RM, Mann S, Watts AE, Peterson RP. PMID: 30525048; PMCID: PMC6256174.
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PubMed Mentions:
7
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Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor. Nat Commun. 2018 03 12; 9(1):1037.
Rivas F, Zahid OK, Reesink HL, Peal BT, Nixon AJ, DeAngelis PL, Skardal A, Rahbar E, Hall AR. PMID: 29531292; PMCID: PMC5847568.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimals
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Galectin-1 and galectin-3 expression in equine mesenchymal stromal cells (MSCs), synovial fibroblasts and chondrocytes, and the effect of inflammation on MSC motility. Stem Cell Res Ther. 2017 Nov 02; 8(1):243.
Reesink HL, Sutton RM, Shurer CR, Peterson RP, Tan JS, Su J, Paszek MJ, Nixon AJ. PMID: 29096716; PMCID: PMC5667510.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Foal Fractures: Osteochondral Fragmentation, Proximal Sesamoid Bone Fractures/Sesamoiditis, and Distal Phalanx Fractures. Vet Clin North Am Equine Pract. 2017 Aug; 33(2):397-416.
Reesink HL. PMID: 28687097.
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Translation:
Animals
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Lubricin/proteoglycan 4 increases in both experimental and naturally occurring equine osteoarthritis. Osteoarthritis Cartilage. 2017 01; 25(1):128-137.
Reesink HL, Watts AE, Mohammed HO, Jay GD, Nixon AJ. PMID: 27498214; PMCID: PMC5489058.
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PubMed Mentions:
29 Fields:
Translation:
Animals
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Galectin-3 Binds to Lubricin and Reinforces the Lubricating Boundary Layer of Articular Cartilage. Sci Rep. 2016 05 09; 6:25463.
Reesink HL, Bonnevie ED, Liu S, Shurer CR, Hollander MJ, Bonassar LJ, Nixon AJ. PMID: 27157803; PMCID: PMC4860590.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Laparoscopic-guided compared to skilled instructor support for student rectal examination training using live horses in the veterinary curriculum. Vet Surg. 2015 Apr; 44(3):352-8.
Radcliffe RM, Manchester AC, Mohammed HO, Ortved K, Reesink HL, Schnabel LV, Lang HM, Scrivani PV, Fubini SL. PMID: 25243819.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Anatomic and neuromuscular characterisation of the equine cricothyroid muscle. Equine Vet J. 2013 Sep; 45(5):630-6.
Reesink HL, Hermanson JW, Cheetham J, Mu L, Mitchell LM, Soderholm LV, Ducharme NG. PMID: 23346975.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Measurement of digital laminar and venous temperatures as a means of comparing three methods of topically applied cold treatment for digits of horses. Am J Vet Res. 2012 Jun; 73(6):860-6.
Reesink HL, Divers TJ, Bookbinder LC, van Eps AW, Soderholm LV, Mohammed HO, Cheetham J. PMID: 22620701.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Continuous peripheral neural blockade to alleviate signs of experimentally induced severe forelimb pain in horses. J Am Vet Med Assoc. 2011 Apr 15; 238(8):1032-9.
Watts AE, Nixon AJ, Reesink HL, Cheetham J, Fubini SL, Looney AL. PMID: 21492047; PMCID: PMC11005056.
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PubMed Mentions:
1 Fields:
Translation:
Animals