William M Ridgway

Title(s)Professor, Rheumatology, Allergy, and Clinical Immunology
SchoolSchool of Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Immunogenetic control of autoimmune biliary disease
    NIH I01BX003821Apr 1, 2018 - Sep 30, 2022
    Role: Principal Investigator
    Mechanistic and therapeutic role of the CD137-CD137L axis in Type 1 Diabetes
    NIH R01DK107541Jul 21, 2016 - Jun 30, 2026
    Role: Co-Principal Investigator
    Mechanism of restored immune tolerance in anti-TLR4 antibody reversal of NOD T1D
    NIH R21AI120084Jun 15, 2015 - May 31, 2017
    Role: Principal Investigator
    Immunogenetic Control of Autoimmune Liver Disease
    NIH I01BX000827Oct 1, 2011 - Sep 30, 2015
    Role: Principal Investigator
    dnTGF Beta RII Mice and PBC
    NIH R01DK090019Sep 30, 2010 - Jun 30, 2020
    Role: Co-Principal Investigator
    Mechanism of NOD.IDD3/10/17/18/9(LD) Liver Disease
    NIH R01DK060714Sep 1, 2002 - Jun 30, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The gut ecosystem and immune tolerance. J Autoimmun. 2023 Dec; 141:103114. Shao T, Hsu R, Rafizadeh DL, Wang L, Bowlus CL, Kumar N, Mishra J, Timilsina S, Ridgway WM, Gershwin ME, Ansari AA, Shuai Z, Leung PSC. PMID: 37748979.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    2. Molecular mimicry and autoimmunity in the time of COVID-19. J Autoimmun. 2023 09; 139:103070. Rojas M, Herrán M, Ramírez-Santana C, Leung PSC, Anaya JM, Ridgway WM, Gershwin ME. PMID: 37390745; PMCID: PMC10258587.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    3. Mutated Pkhd1 alone is sufficient to cause autoimmune biliary disease on the nonobese diabetic (NOD) genetic background. Immunogenetics. 2023 02; 75(1):27-37. Adams DE, Heuer LS, Rojas M, Zhang W, Ridgway WM. PMID: 36097289; PMCID: PMC9468241.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Treatment with a JAK1/2 inhibitor ameliorates murine autoimmune cholangitis induced by IFN overexpression. Cell Mol Immunol. 2022 10; 19(10):1130-1140. Shao T, Leung PSC, Zhang W, Tsuneyama K, Ridgway WM, Young HA, Shuai Z, Ansari AA, Gershwin ME. PMID: 36042351; PMCID: PMC9508183.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    5. Dual B-cell targeting therapy ameliorates autoimmune cholangitis. J Autoimmun. 2022 10; 132:102897. Zhang W, Shao T, Leung PSC, Tsuneyama K, Heuer L, Young HA, Ridgway WM, Gershwin ME. PMID: 36029718; PMCID: PMC10311358.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    6. The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes. Front Immunol. 2022; 13:918837. Rojas M, Heuer LS, Zhang W, Chen YG, Ridgway WM. PMID: 35935980; PMCID: PMC9353112.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Endosomal Sequestration of TLR4 Antibody Induces Myeloid-Derived Suppressor Cells and Reverses Acute Type 1 Diabetes. Diabetes. 2022 03 01; 71(3):470-482. Locker KCS, Kachapati K, Wu Y, Bednar KJ, Adams D, Patel C, Tsukamoto H, Heuer LS, Aronow BJ, Herr AB, Ridgway WM. PMID: 35040474; PMCID: PMC8893939.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    8. E. coli and the etiology of human PBC: Antimitochondrial antibodies and spreading determinants. Hepatology. 2022 02; 75(2):266-279. Yang Y, Choi J, Chen Y, Invernizzi P, Yang G, Zhang W, Shao TH, Jordan F, Nemeria NS, Coppel RL, Ridgway WM, Kurth M, Ansari AA, Leung PSC, Gershwin ME. PMID: 34608663.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    9. Enhancing Antigen Presentation and Inducing Antigen-Specific Immune Tolerance with Amphiphilic Peptides. J Immunol. 2021 10 15; 207(8):2051-2059. Li M, Itoh A, Xi J, Yu C, Wu Y, Ridgway WM, Liu H. PMID: 34526376; PMCID: PMC8492530.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    10. The myristoylated alanine-rich C-kinase substrates (MARCKS): A membrane-anchored mediator of the cell function. Autoimmun Rev. 2021 Nov; 20(11):102942. Chen Z, Zhang W, Selmi C, Ridgway WM, Leung PSC, Zhang F, Gershwin ME. PMID: 34509657.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    11. Enoxacin Up-Regulates MicroRNA Biogenesis and Down-Regulates Cytotoxic CD8 T-Cell Function in Autoimmune Cholangitis. Hepatology. 2021 08; 74(2):835-846. Itoh A, Adams D, Huang W, Wu Y, Kachapati K, Bednar KJ, Leung PSC, Zhang W, Flavell RA, Gershwin ME, Ridgway WM. PMID: 33462854.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    12. Antibody glycosylation in autoimmune diseases. Autoimmun Rev. 2021 May; 20(5):102804. Zhou X, Motta F, Selmi C, Ridgway WM, Gershwin ME, Zhang W. PMID: 33727152; PMCID: PMC8058319.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    13. Autoinflammatory and autoimmune conditions at the crossroad of COVID-19. J Autoimmun. 2020 11; 114:102506. Rodríguez Y, Novelli L, Rojas M, De Santis M, Acosta-Ampudia Y, Monsalve DM, Ramírez-Santana C, Costanzo A, Ridgway WM, Ansari AA, Gershwin ME, Selmi C, Anaya JM. PMID: 32563547; PMCID: PMC7296326.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCellsPHPublic Health
    14. Glycomic analysis of antibody indicates distinctive glycosylation profile in patients with autoimmune cholangitis. J Autoimmun. 2020 09; 113:102503. Zhou X, Kailemia MJ, Sun Y, Shuai Z, Yang GX, Dhaliwal S, Cristoferi L, Leung PSC, Invernizzi P, Bowlus CL, Lebrilla CB, Ansari AA, Ridgway WM, Zhang W, Gershwin ME. PMID: 32546343.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    15. The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137+ FOXP3+ Regulatory CD4 T Cells. J Immunol. 2020 06 01; 204(11):2887-2899. Foda BM, Ciecko AE, Serreze DV, Ridgway WM, Geurts AM, Chen YG. PMID: 32295876; PMCID: PMC7296588.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    16. Recommendations for coronavirus infection in rheumatic diseases treated with biologic therapy. J Autoimmun. 2020 05; 109:102442. Ceribelli A, Motta F, De Santis M, Ansari AA, Ridgway WM, Gershwin ME, Selmi C. PMID: 32253068; PMCID: PMC7127009.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCellsPHPublic Health
    17. Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy. Front Immunol. 2019; 10:2566. Itoh A, Ortiz L, Kachapati K, Wu Y, Adams D, Bednar K, Mukherjee S, Chougnet C, Mittler RS, Chen YG, Dolan L, Ridgway WM. PMID: 31787971; PMCID: PMC6853870.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    18. Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4+ T cells. Cell Mol Immunol. 2020 02; 17(2):178-189. Zhao ZB, Lu FT, Ma HD, Wang YH, Yang W, Long J, Miao Q, Zhang W, Tian Z, Ridgway WM, Cao J, Gershwin ME, Lian ZX. PMID: 30874628; PMCID: PMC7000693.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    19. Proteomic analysis reveals distinctive protein profiles involved in CD8+ T cell-mediated murine autoimmune cholangitis. Cell Mol Immunol. 2018 08; 15(8):756-767. Zhang W, Zhang R, Zhang J, Sun Y, Leung PS, Yang GX, Shuai Z, Ridgway WM, Gershwin ME. PMID: 29375127; PMCID: PMC6141482.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    20. A Novel Pkhd1 Mutation Interacts with the Nonobese Diabetic Genetic Background To Cause Autoimmune Cholangitis. J Immunol. 2018 01 01; 200(1):147-162. Huang W, Rainbow DB, Wu Y, Adams D, Shivakumar P, Kottyan L, Karns R, Aronow B, Bezerra J, Gershwin ME, Peterson LB, Wicker LS, Ridgway WM. PMID: 29158418; PMCID: PMC5757511.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    21. GLP-1 receptor agonist, liraglutide, ameliorates hepatosteatosis induced by anti-CD3 antibody in female mice. J Diabetes Complications. 2017 Sep; 31(9):1370-1375. Itoh A, Irie J, Tagawa H, Kusumoto Y, Kato M, Kobayashi N, Tanaka K, Kikuchi R, Fujita M, Nakajima Y, Wu Y, Yamada S, Kawai T, Ridgway WM, Itoh H. PMID: 28684145.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes. Immunotargets Ther. 2017; 6:31-38. Itoh A, Ridgway WM. PMID: 28580341; PMCID: PMC5448691.
      View in: PubMed   Mentions: 19  
    23. CD137 Plays Both Pathogenic and Protective Roles in Type 1 Diabetes Development in NOD Mice. J Immunol. 2017 05 15; 198(10):3857-3868. Forsberg MH, Ciecko AE, Bednar KJ, Itoh A, Kachapati K, Ridgway WM, Chen YG. PMID: 28363905; PMCID: PMC5426805.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    24. Chemokine receptor CXCR3 deficiency exacerbates murine autoimmune cholangitis by promoting pathogenic CD8+ T cell activation. J Autoimmun. 2017 03; 78:19-28. Ma HD, Ma WT, Liu QZ, Zhao ZB, Liu MZ, Tsuneyama K, Gao JM, Ridgway WM, Ansari AA, Gershwin ME, Fei YY, Lian ZX. PMID: 28129932; PMCID: PMC5357510.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    25. Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice. Clin Exp Immunol. 2016 08; 185(2):154-64. Yang GX, Sun Y, Tsuneyama K, Zhang W, Leung PS, He XS, Ansari AA, Bowlus C, Ridgway WM, Gershwin ME. PMID: 27148790; PMCID: PMC4955007.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    26. Successful treatment of murine autoimmune cholangitis by parabiosis: Implications for hematopoietic therapy. J Autoimmun. 2016 Jan; 66:108-17. Yang JB, Wang YH, Yang W, Lu FT, Ma HD, Zhao ZB, Jia YJ, Tang W, Tsuneyama K, Ridgway WM, Gershwin ME, Lian ZX. PMID: 26432598; PMCID: PMC4829433.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    27. Reversal of New-Onset Type 1 Diabetes With an Agonistic TLR4/MD-2 Monoclonal Antibody. Diabetes. 2015 Oct; 64(10):3614-26. Bednar KJ, Tsukamoto H, Kachapati K, Ohta S, Wu Y, Katz JD, Ascherman DP, Ridgway WM. PMID: 26130764; PMCID: PMC9162148.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    28. Systems biologic analysis of T regulatory cells genetic pathways in murine primary biliary cirrhosis. J Autoimmun. 2015 May; 59:26-37. Wang YH, Yang W, Yang JB, Jia YJ, Tang W, Gershwin ME, Ridgway WM, Lian ZX. PMID: 25701076; PMCID: PMC4829434.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    29. Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3(+) regulatory T cells. Clin Exp Immunol. 2014 Nov; 178(2):253-61. Tanaka H, Zhang W, Yang GX, Ando Y, Tomiyama T, Tsuneyama K, Leung P, Coppel RL, Ansari AA, Lian ZX, Ridgway WM, Joh T, Gershwin ME. PMID: 25041369; PMCID: PMC4233375.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    30. Prometheus unbound: NKT cells inhibit hepatic regeneration. Hepatology. 2014 Oct; 60(4):1133-5. Ridgway WM, Gershwin ME. PMID: 24824434; PMCID: PMC4174721.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    31. Differential modulation by IL-17A of Cholangitis versus Colitis in IL-2Rα deleted mice. PLoS One. 2014; 9(8):e105351. Yang W, Yao Y, Yang YQ, Lu FT, Li L, Wang YH, Nakajima T, Tsuneyama K, Ridgway WM, Gershwin ME, Lian ZX. PMID: 25133396; PMCID: PMC4136813.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    32. Animal models of primary biliary cirrhosis. Semin Liver Dis. 2014 Aug; 34(3):285-96. Wang J, Yang GX, Tsuneyama K, Gershwin ME, Ridgway WM, Leung PS. PMID: 25057952.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    33. Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells. J Autoimmun. 2014 May; 50:123-34. Huang W, Kachapati K, Adams D, Wu Y, Leung PS, Yang GX, Zhang W, Ansari AA, Flavell RA, Gershwin ME, Ridgway WM. PMID: 24556277; PMCID: PMC4098881.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    34. Escherichia coli infection induces autoimmune cholangitis and anti-mitochondrial antibodies in non-obese diabetic (NOD).B6 (Idd10/Idd18) mice. Clin Exp Immunol. 2014 Feb; 175(2):192-201. Wang JJ, Yang GX, Zhang WC, Lu L, Tsuneyama K, Kronenberg M, Véla JL, Lopez-Hoyos M, He XS, Ridgway WM, Leung PS, Gershwin ME. PMID: 24128311; PMCID: PMC3892410.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    35. A new tool for dissecting genetic control of type 1 diabetes. Diabetes. 2014 Jan; 63(1):56-8. Ridgway WM. PMID: 24357698.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    36. Targeting innate immunity for treatment of type 1 diabetes. Immunotherapy. 2014; 6(12):1239-42. Bednar KJ, Ridgway WM. PMID: 25524380.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    37. Recombinant soluble CD137 prevents type one diabetes in nonobese diabetic mice. J Autoimmun. 2013 Dec; 47:94-103. Kachapati K, Bednar KJ, Adams DE, Wu Y, Mittler RS, Jordan MB, Hinerman JM, Herr AB, Ridgway WM. PMID: 24145149.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    38. Clonality, activated antigen-specific CD8(+) T cells, and development of autoimmune cholangitis in dnTGFβRII mice. Hepatology. 2013 Sep; 58(3):1094-104. Kawata K, Yang GX, Ando Y, Tanaka H, Zhang W, Kobayashi Y, Tsuneyama K, Leung PS, Lian ZX, Ridgway WM, Ansari AA, He XS, Gershwin ME. PMID: 23532950; PMCID: PMC3716874.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    39. Functional redundancy of MyD88-dependent signaling pathways in a murine model of histidyl-transfer RNA synthetase-induced myositis. J Immunol. 2013 Aug 15; 191(4):1865-72. Fernandez I, Harlow L, Zang Y, Liu-Bryan R, Ridgway WM, Clemens PR, Ascherman DP. PMID: 23842751; PMCID: PMC4332536.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    40. Reply: To PMID 22996325. Hepatology. 2013 Aug; 58(2):830. Gershwin ME, Leung PS, Ridgway WM, Coppel RL, Ansari AA. PMID: 23315750.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    41. Overexpression of microRNA-21 is associated with elevated pro-inflammatory cytokines in dominant-negative TGF-β receptor type II mouse. J Autoimmun. 2013 Mar; 41:111-9. Ando Y, Yang GX, Kenny TP, Kawata K, Zhang W, Huang W, Leung PS, Lian ZX, Okazaki K, Ansari AA, He XS, Invernizzi P, Ridgway WM, Lu Q, Gershwin ME. PMID: 23395552; PMCID: PMC3622842.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    42. Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice. Hepatology. 2013 Feb; 57(2):806-16. Tsuda M, Zhang W, Yang GX, Tsuneyama K, Ando Y, Kawata K, Park O, Leung PS, Coppel RL, Ansari AA, Ridgway WM, Gao B, Lian ZX, Flavell R, He XS, Gershwin ME. PMID: 22576253; PMCID: PMC3424295.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    43. Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFβ receptor II. PLoS One. 2012; 7(11):e49413. Zhang W, Tsuda M, Yang GX, Tsuneyama K, He XS, Ansari AA, Ridgway WM, Coppel RL, Lian ZX, Leung PS, Gershwin ME. PMID: 23145171; PMCID: PMC3492285.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    44. The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model. J Immunol. 2012 Nov 15; 189(10):5001-15. Kachapati K, Adams DE, Wu Y, Steward CA, Rainbow DB, Wicker LS, Mittler RS, Ridgway WM. PMID: 23066155; PMCID: PMC3505683.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    45. The immunobiology of colitis and cholangitis in interleukin-23p19 and interleukin-17A deleted dominant negative form of transforming growth factor beta receptor type II mice. Hepatology. 2012 Oct; 56(4):1418-26. Ando Y, Yang GX, Tsuda M, Kawata K, Zhang W, Nakajima T, Tsuneyama K, Leung P, Lian ZX, Okazaki K, Ridgway WM, Norman GL, Ansari AA, He XS, Coppel RL, Gershwin ME. PMID: 22532156; PMCID: PMC3415593.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    46. Characterization of TLR4-mediated auto-antibody production in a mouse model of histidyl-tRNA synthetase-induced myositis. Innate Immun. 2012 Dec; 18(6):876-85. Harlow L, Fernandez I, Soejima M, Ridgway WM, Ascherman DP. PMID: 22582345.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    47. Animal models of primary biliary cirrhosis: materials and methods. Methods Mol Biol. 2012; 900:291-316. Leung PS, Yang GX, Dhirapong A, Tsuneyama K, Ridgway WM, Gershwin ME. PMID: 22933075.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    48. The non-obese diabetic (NOD) mouse as a model of human type 1 diabetes. Methods Mol Biol. 2012; 933:3-16. Kachapati K, Adams D, Bednar K, Ridgway WM. PMID: 22893397.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    49. Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice. J Immunol. 2011 Jul 01; 187(1):325-36. Rainbow DB, Moule C, Fraser HI, Clark J, Howlett SK, Burren O, Christensen M, Moody V, Steward CA, Mohammed JP, Fusakio ME, Masteller EL, Finger EB, Houchins JP, Naf D, Koentgen F, Ridgway WM, Todd JA, Bluestone JA, Peterson LB, Mattner J, Wicker LS. PMID: 21613616; PMCID: PMC3128927.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    50. Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity. J Immunol. 2011 Jul 01; 187(1):337-49. Mohammed JP, Fusakio ME, Rainbow DB, Moule C, Fraser HI, Clark J, Todd JA, Peterson LB, Savage PB, Wills-Karp M, Ridgway WM, Wicker LS, Mattner J. PMID: 21613619; PMCID: PMC3134939.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    51. B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis. Cell Immunol. 2011; 268(1):16-23. Moritoki Y, Tsuda M, Tsuneyama K, Zhang W, Yoshida K, Lian ZX, Yang GX, Ridgway WM, Wicker LS, Ansari AA, Gershwin ME. PMID: 21349500; PMCID: PMC3056928.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    52. CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease. J Immunol. 2011 Jan 15; 186(2):1259-67. Yang GX, Wu Y, Tsukamoto H, Leung PS, Lian ZX, Rainbow DB, Hunter KM, Morris GA, Lyons PA, Peterson LB, Wicker LS, Gershwin ME, Ridgway WM. PMID: 21169553; PMCID: PMC4975520.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    53. Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis. Hepatology. 2010 Jul; 52(1):215-22. Zhang W, Tsuda M, Yang GX, Tsuneyama K, Rong G, Ridgway WM, Ansari AA, Flavell RA, Coppel RL, Lian ZX, Gershwin ME. PMID: 20578264; PMCID: PMC2936774.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    54. Murine models of autoimmune cholangitis. Curr Opin Gastroenterol. 2010 May; 26(3):274-9. Ueno Y, Ambrosini YM, Moritoki Y, Ridgway WM, Gershwin ME. PMID: 20224397.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    55. Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin-2Ralpha(-/-) mice. Hepatology. 2009 Jan; 49(1):133-40. Hsu W, Zhang W, Tsuneyama K, Moritoki Y, Ridgway WM, Ansari AA, Coppel RL, Lian ZX, Mackay I, Gershwin ME. PMID: 19065673; PMCID: PMC2614451.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    56. Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization. Clin Exp Immunol. 2009 Mar; 155(3):577-86. Wakabayashi K, Yoshida K, Leung PS, Moritoki Y, Yang GX, Tsuneyama K, Lian ZX, Hibi T, Ansari AA, Wicker LS, Ridgway WM, Coppel RL, Mackay IR, Gershwin ME. PMID: 19094117; PMCID: PMC2669535.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCellsPHPublic Health
    57. B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology. 2009 Mar; 136(3):1037-47. Moritoki Y, Zhang W, Tsuneyama K, Yoshida K, Wakabayashi K, Yang GX, Bowlus C, Ridgway WM, Ueno Y, Ansari AA, Coppel RL, Mackay IR, Flavell RA, Gershwin ME, Lian ZX. PMID: 19118554.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    58. Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology. 2008 Aug; 48(2):531-40. Wakabayashi K, Lian ZX, Leung PS, Moritoki Y, Tsuneyama K, Kurth MJ, Lam KS, Yoshida K, Yang GX, Hibi T, Ansari AA, Ridgway WM, Coppel RL, Mackay IR, Gershwin ME. PMID: 18563844; PMCID: PMC3753011.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCellsPHPublic Health
    59. Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice. Hepatology. 2008 Jun; 47(6):1974-82. Yang GX, Lian ZX, Chuang YH, Moritoki Y, Lan RY, Wakabayashi K, Ansari AA, Flavell RA, Ridgway WM, Coppel RL, Tsuneyama K, Mackay IR, Gershwin ME. PMID: 18452147; PMCID: PMC2749317.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    60. Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host Microbe. 2008 May 15; 3(5):304-15. Mattner J, Savage PB, Leung P, Oertelt SS, Wang V, Trivedi O, Scanlon ST, Pendem K, Teyton L, Hart J, Ridgway WM, Wicker LS, Gershwin ME, Bendelac A. PMID: 18474357; PMCID: PMC2453520.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    61. Animal models of primary biliary cirrhosis. Clin Liver Dis. 2008 May; 12(2):333-47; ix. Chuang YH, Ridgway WM, Ueno Y, Gershwin ME. PMID: 18456184; PMCID: PMC2476212.
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    62. Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis. Hepatology. 2008 Feb; 47(2):571-80. Chuang YH, Lian ZX, Yang GX, Shu SA, Moritoki Y, Ridgway WM, Ansari AA, Kronenberg M, Flavell RA, Gao B, Gershwin ME. PMID: 18098320.
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    63. Genome-wide microarray expression analysis of CD4+ T Cells from nonobese diabetic congenic mice identifies Cd55 (Daf1) and Acadl as candidate genes for type 1 diabetes. J Immunol. 2008 Jan 15; 180(2):1071-9. Irie J, Reck B, Wu Y, Wicker LS, Howlett S, Rainbow D, Feingold E, Ridgway WM. PMID: 18178847; PMCID: PMC2590658.
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    64. Gene-gene interactions in the NOD mouse model of type 1 diabetes. Adv Immunol. 2008; 100:151-75. Ridgway WM, Peterson LB, Todd JA, Rainbow DB, Healy B, Burren OS, Wicker LS. PMID: 19111166.
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    65. High cell surface expression of CD4 allows distinction of CD4(+)CD25(+) antigen-specific effector T cells from CD4(+)CD25(+) regulatory T cells in murine experimental autoimmune encephalomyelitis. J Neuroimmunol. 2007 Dec; 192(1-2):57-67. Li J, Ridgway W, Fathman CG, Tse HY, Shaw MK. PMID: 17920698; PMCID: PMC2212588.
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    66. Murine models of primary biliary cirrhosis: Comparisons and contrasts. Hepatol Res. 2007 Oct; 37 Suppl 3:S365-9. Oertelt S, Ridgway WM, Ansari AA, Coppel RL, Gershwin ME. PMID: 17931188.
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    67. Species-specific immune responses generated by histidyl-tRNA synthetase immunization are associated with muscle and lung inflammation. J Autoimmun. 2007 Sep-Nov; 29(2-3):174-86. Katsumata Y, Ridgway WM, Oriss T, Gu X, Chin D, Wu Y, Fertig N, Oury T, Vandersteen D, Clemens P, Camacho CJ, Weinberg A, Ascherman DP. PMID: 17826948; PMCID: PMC2639656.
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    68. New tools for defining the 'genetic background' of inbred mouse strains. Nat Immunol. 2007 Jul; 8(7):669-73. Ridgway WM, Healy B, Smink LJ, Rainbow D, Wicker LS. PMID: 17579641.
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    69. Autoimmune cholangitis in NOD.c3c4 mice is associated with cholangiocyte-specific Fas antigen deficiency. J Autoimmun. 2007 08; 29(1):20-9. Nakagome Y, Ueno Y, Kogure T, Fukushima K, Moritoki Y, Ridgway WM, Gershwin ME, Shimosegawa T. PMID: 17482429.
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    70. Modulating protective and pathogenic CD4+ subsets via CD137 in type 1 diabetes. Diabetes. 2007 Jan; 56(1):186-96. Irie J, Wu Y, Kachapati K, Mittler RS, Ridgway WM. PMID: 17192481.
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    71. IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis. Hepatology. 2006 Nov; 44(5):1240-9. Wakabayashi K, Lian ZX, Moritoki Y, Lan RY, Tsuneyama K, Chuang YH, Yang GX, Ridgway W, Ueno Y, Ansari AA, Coppel RL, Mackay IR, Gershwin ME. PMID: 17058261.
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    72. Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. J Immunol. 2006 Aug 01; 177(3):1655-60. Oertelt S, Lian ZX, Cheng CM, Chuang YH, Padgett KA, He XS, Ridgway WM, Ansari AA, Coppel RL, Li MO, Flavell RA, Kronenberg M, Mackay IR, Gershwin ME. PMID: 16849474.
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    73. NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis. J Exp Med. 2006 May 15; 203(5):1209-19. Irie J, Wu Y, Wicker LS, Rainbow D, Nalesnik MA, Hirsch R, Peterson LB, Leung PS, Cheng C, Mackay IR, Gershwin ME, Ridgway WM. PMID: 16636131; PMCID: PMC2121204.
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    74. Genetic control of anti-Sm autoantibody production in NOD congenic mice narrowed to the Idd9.3 region. Immunogenetics. 2006 Feb; 58(1):9-14. Irie J, Wu Y, Sass DA, Ridgway WM. PMID: 16425035.
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    75. Dissecting genetic control of autoimmunity in NOD congenic mice. Immunol Res. 2006; 36(1-3):189-95. Ridgway WM. PMID: 17337779; PMCID: PMC3505680.
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    76. New insights to the immunopathology and autoimmune responses in primary biliary cirrhosis. Cell Immunol. 2006 Jan; 239(1):1-13. He XS, Ansari AA, Ridgway WM, Coppel RL, Gershwin ME. PMID: 16765923.
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    77. A modular theory of autoimmunity. Keio J Med. 2005 Sep; 54(3):121-6. Irie J, Ridgway WM. PMID: 16237273.
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    78. NOD mice and autoimmunity. Autoimmun Rev. 2005 Jul; 4(6):373-9. Aoki CA, Borchers AT, Ridgway WM, Keen CL, Ansari AA, Gershwin ME. PMID: 16081028.
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    79. Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain. J Immunol. 2004 Aug 15; 173(4):2315-23. Koarada S, Wu Y, Fertig N, Sass DA, Nalesnik M, Todd JA, Lyons PA, Fenyk-Melody J, Rainbow DB, Wicker LS, Peterson LB, Ridgway WM. PMID: 15294944.
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    80. Nonobese diabetic CD4 lymphocytosis maps outside the MHC locus on chromosome 17. Immunogenetics. 2004 Aug; 56(5):333-7. Koarada S, Wu Y, Yim YS, Wakeland EW, Ridgway WM. PMID: 15309345.
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    81. The non obese diabetic (NOD) mouse: a unique model for understanding the interaction between genetics and T cell responses. Rev Endocr Metab Disord. 2003 Sep; 4(3):263-9. Ridgway WM. PMID: 14501177.
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    82. Increased entry into the IFN-gamma effector pathway by CD4+ T cells selected by I-Ag7 on a nonobese diabetic versus C57BL/6 genetic background. J Immunol. 2001 Aug 01; 167(3):1693-702. Koarada S, Wu Y, Ridgway WM. PMID: 11466393.
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    83. T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivo. J Exp Med. 2000 Dec 18; 192(12):1719-30. Fassò M, Anandasabapathy N, Crawford F, Kappler J, Fathman CG, Ridgway WM. PMID: 11120769; PMCID: PMC2213496.
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    84. Identification and characterization of the antigen-specific subpopulation of alloreactive CD4+ T cells in vitro and in vivo. Transplantation. 2000 Feb 27; 69(4):605-9. Krieger NR, Fathman CG, Shaw MK, Ridgway WM. PMID: 10708118.
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    85. MHC structure and autoimmune T cell repertoire development. Curr Opin Immunol. 1999 Dec; 11(6):638-42. Ridgway WM, Fathman CG. PMID: 10631548.
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    86. A new look at MHC and autoimmune disease. Science. 1999 Apr 30; 284(5415):749, 751. Ridgway WM, Fassò M, Fathman CG. PMID: 10336398.
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    87. Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response. J Exp Med. 1998 Dec 21; 188(12):2267-75. Ridgway WM, Ito H, Fassò M, Yu C, Fathman CG. PMID: 9858513; PMCID: PMC2212423.
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    88. Following antigen challenge, T cells up-regulate cell surface expression of CD4 in vitro and in vivo. J Immunol. 1998 Jul 15; 161(2):714-20. Ridgway W, Fassò M, Fathman CG. PMID: 9670947.
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    89. The association of MHC with autoimmune diseases: understanding the pathogenesis of autoimmune diabetes. Clin Immunol Immunopathol. 1998 Jan; 86(1):3-10. Ridgway WM, Fathman CG. PMID: 9434791.
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    90. Breaking self-tolerance in nonobese diabetic mice. J Exp Med. 1996 Apr 01; 183(4):1657-62. Ridgway WM, Fassò M, Lanctot A, Garvey C, Fathman CG. PMID: 8666923; PMCID: PMC2192523.
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    91. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol. 1996 Jan 01; 156(1):5-7. Ferber IA, Brocke S, Taylor-Edwards C, Ridgway W, Dinisco C, Steinman L, Dalton D, Fathman CG. PMID: 8598493.
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    92. Regulation of autoimmune response. Curr Opin Immunol. 1994 Dec; 6(6):946-55. Ridgway WM, Weiner HL, Fathman CG. PMID: 7710719.
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    93. Aggressive drug therapy for rheumatoid arthritis. Hosp Pract (Off Ed). 1993 Sep 15; 28(9):45-52. McGuire JL, Ridgway WM. PMID: 8366157.
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