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Valentina Medici

Title(s)Associate Professor, Gastroenterology and Hepatology
SchoolUniversity of California, Davis
Phone916-734-3751
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Medici V, LaSalle JM. Genetics and epigenetic factors of Wilson disease. Ann Transl Med. 2019 Apr; 7(Suppl 2):S58. PMID: 31179295.
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    2. Sarode GV, Kim K, Kieffer DA, Shibata NM, Litwin T, Czlonkowska A, Medici V. Metabolomics profiles of patients with Wilson disease reveal a distinct metabolic signature. Metabolomics. 2019 Mar 12; 15(3):43. PMID: 30868361.
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    3. Mordaunt CE, Kieffer DA, Shibata NM, Czlonkowska A, Litwin T, Weiss KH, Zhu Y, Bowlus CL, Sarkar S, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V. Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers. Epigenetics Chromatin. 2019 02 01; 12(1):10. PMID: 30709419.
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    4. Kuftinec GN, Levy R, Kieffer DA, Medici V. Hepatocellular Carcinoma and Associated Clinical Features in Latino and Caucasian Patients from a Single Center. Ann Hepatol. 2019 Jan - Feb; 18(1):177-186. PMID: 31113588.
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    5. Kuftinec GN, Levy R, Kieffer DA, Medici V. Hepatocellular Carcinoma and Associated Clinical Features in Latino and Caucasian Patients from a Single Center. Ann Hepatol. 2018 Dec 13; 18(1):177-186. PMID: 30596601.
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    6. Mordaunt CE, Shibata NM, Kieffer DA, Czlonkowska A, Litwin T, Weiss KH, Gotthardt DN, Olson K, Wei D, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V. Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease. Hum Mol Genet. 2018 11 15; 27(22):3854-3869. PMID: 30010856.
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    7. Koo PT, Medici V, Tabibian JH. Anastomotic Biliary Stricture Development after Liver Transplantation in the Setting of Retained Prophylactic Intraductal Pediatric Feeding Tube: Case and Review. Case Reports Hepatol. 2018; 2018:4707389. PMID: 30363933.
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    8. Czlonkowska A, Litwin T, Dusek P, Ferenci P, Lutsenko S, Medici V, Rybakowski JK, Weiss KH, Schilsky ML. Wilson disease. Nat Rev Dis Primers. 2018 09 06; 4(1):21. PMID: 30190489.
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    9. Gershuni VM, Yan SL, Medici V. Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome. Curr Nutr Rep. 2018 09; 7(3):97-106. PMID: 30128963.
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    10. Sankararaman S, Syed W, Medici V, Sferra TJ. Impact of Energy Drinks on Health and Well-being. Curr Nutr Rep. 2018 09; 7(3):121-130. PMID: 29982915.
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    11. Price CA, Argueta DA, Medici V, Bremer AA, Lee V, Nunez MV, Chen GX, Keim NL, Havel PJ, Stanhope KL, DiPatrizio NV. Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII, and ApoE in humans consuming a high-fructose corn syrup-sweetened beverage. Am J Physiol Endocrinol Metab. 2018 08 01; 315(2):E141-E149. PMID: 29634315.
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    12. Pinon-Gutierrez R, Durbin-Johnson B, Halsted CH, Medici V. Clinical features of alcoholic hepatitis in latinos and caucasians: A single center experience. World J Gastroenterol. 2017 Oct 28; 23(40):7274-7282. PMID: 29142474.
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    13. Kieffer DA, Medici V. Wilson disease: At the crossroads between genetics and epigenetics-A review of the evidence. Liver Res. 2017 Sep; 1(2):121-130. PMID: 29270329.
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    14. Molfino A, Johnson S, Medici V. The Challenges of Nutritional Assessment in Cirrhosis. Curr Nutr Rep. 2017 Sep; 6(3):274-280. PMID: 29201536.
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    15. Yokoyama AS, Rutledge JC, Medici V. DNA methylation alterations in Alzheimer's disease. Environ Epigenet. 2017 May; 3(2):dvx008. PMID: 29492310.
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    16. López-Yoldi M, Stanhope KL, Garaulet M, Chen XG, Marcos-Gómez B, Carrasco-Benso MP, Santa Maria EM, Escoté X, Lee V, Nunez MV, Medici V, Martínez-Ansó E, Sáinz N, Huerta AE, Laiglesia LM, Prieto J, Martínez JA, Bustos M, Havel PJ, Moreno-Aliaga MJ. Role of cardiotrophin-1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice and characterization of 24-h circulating CT-1 profiles in normal-weight and overweight/obese subjects. FASEB J. 2017 04; 31(4):1639-1649. PMID: 28096235.
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    17. Medici V, Huster D. Animal models of Wilson disease. Handb Clin Neurol. 2017; 142:57-70. PMID: 28433110.
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    18. Medici V, Weiss KH. Genetic and environmental modifiers of Wilson disease. Handb Clin Neurol. 2017; 142:35-41. PMID: 28433108.
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    19. Chao A, Waitzberg D, de Jesus RP, Bueno AA, Kha V, Allen K, Kappus M, Medici V. Malnutrition and Nutritional Support in Alcoholic Liver Disease: a Review. Curr Gastroenterol Rep. 2016 Dec; 18(12):65. PMID: 27787787.
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    20. Kappus MR, Saire Mendoza M, Nguyen D, Medici V, McClave SA. Erratum to: Sarcopenia in Patients with Chronic Liver Disease: Can It Be Altered by Diet and Exercise? Curr Gastroenterol Rep. 2016 Nov; 18(11):57. PMID: 27641726.
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    21. Nguyen DL, Limketkai B, Medici V, Saire Mendoza M, Palmer L, Bechtold M. Nutritional Strategies in the Management of Adult Patients with Inflammatory Bowel Disease: Dietary Considerations from Active Disease to Disease Remission. Curr Gastroenterol Rep. 2016 Oct; 18(10):55. PMID: 27637649.
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    22. Medici V, Kieffer DA, Shibata NM, Chima H, Kim K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda KK, Olson K, Su RJ, Islam MS, Syed R, Keen CL, Miller AY, Rutledge JC, Halsted CH, LaSalle JM. Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model. Epigenetics. 2016 Nov; 11(11):804-818. PMID: 27611852.
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    23. Kappus MR, Mendoza MS, Nguyen D, Medici V, McClave SA. Sarcopenia in Patients with Chronic Liver Disease: Can It Be Altered by Diet and Exercise? Curr Gastroenterol Rep. 2016 Aug; 18(8):43. PMID: 27372291.
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    24. Medici V, Rossini L, Deleo F, Tringali G, Tassi L, Cardinale F, Bramerio M, de Curtis M, Garbelli R, Spreafico R. Different parvalbumin and GABA expression in human epileptogenic focal cortical dysplasia. Epilepsia. 2016 07; 57(7):1109-19. PMID: 27173597.
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    25. Syed R, Shibata NM, Kharbanda KK, Su RJ, Olson K, Yokoyama A, Rutledge JC, Chmiel KJ, Kim K, Halsted CH, Medici V. Effects of Nonpurified and Choline Supplemented or Nonsupplemented Purified Diets on Hepatic Steatosis and Methionine Metabolism in C3H Mice. Metab Syndr Relat Disord. 2016 May; 14(4):202-9. PMID: 26881897.
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    26. Medici V, McClave SA, Miller KR. Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity. Curr Gastroenterol Rep. 2016 Jan; 18(1):2. PMID: 26700070.
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    27. Zucca I, Milesi G, Medici V, Tassi L, Didato G, Cardinale F, Tringali G, Colombo N, Bramerio M, D'Incerti L, Freri E, Morbin M, Fugnanesi V, Figini M, Spreafico R, Garbelli R. Type II focal cortical dysplasia: Ex vivo 7T magnetic resonance imaging abnormalities and histopathological comparisons. Ann Neurol. 2016 Jan; 79(1):42-58. PMID: 26448158.
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    28. Butler AA, St-Onge MP, Siebert EA, Medici V, Stanhope KL, Havel PJ. Differential Responses of Plasma Adropin Concentrations To Dietary Glucose or Fructose Consumption In Humans. Sci Rep. 2015 Oct 05; 5:14691. PMID: 26435060.
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    29. Stanhope KL, Medici V, Bremer AA, Lee V, Lam HD, Nunez MV, Chen GX, Keim NL, Havel PJ. A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults. Am J Clin Nutr. 2015 Jun; 101(6):1144-54. PMID: 25904601.
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    30. Tryon MS, Stanhope KL, Epel ES, Mason AE, Brown R, Medici V, Havel PJ, Laugero KD. Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body. J Clin Endocrinol Metab. 2015 Jun; 100(6):2239-47. PMID: 25879513.
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    31. Levy R, Catana AM, Durbin-Johnson B, Halsted CH, Medici V. Ethnic differences in presentation and severity of alcoholic liver disease. Alcohol Clin Exp Res. 2015 Mar; 39(3):566-574. PMID: 25702770.
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    32. Torruellas C, French SW, Medici V. Diagnosis of alcoholic liver disease. World J Gastroenterol. 2014 Sep 07; 20(33):11684-99. PMID: 25206273.
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    33. Le A, Shibata NM, French SW, Kim K, Kharbanda KK, Islam MS, LaSalle JM, Halsted CH, Keen CL, Medici V. Characterization of timed changes in hepatic copper concentrations, methionine metabolism, gene expression, and global DNA methylation in the Jackson toxic milk mouse model of Wilson disease. Int J Mol Sci. 2014 May 07; 15(5):8004-23. PMID: 24810691.
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    34. Rossini L, Medici V, Tassi L, Cardinale F, Tringali G, Bramerio M, Villani F, Spreafico R, Garbelli R. Layer-specific gene expression in epileptogenic type II focal cortical dysplasia: normal-looking neurons reveal the presence of a hidden laminar organization. Acta Neuropathol Commun. 2014 Apr 15; 2:45. PMID: 24735483.
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    35. Medici V, Schroeder DI, Woods R, LaSalle JM, Geng Y, Shibata NM, Peerson J, Hodzic E, Dayal S, Tsukamoto H, Kharbanda KK, Tillman B, French SW, Halsted CH. Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse. Alcohol Clin Exp Res. 2014 Jun; 38(6):1540-9. PMID: 24730561.
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    36. Medici V, Shibata NM, Kharbanda KK, Islam MS, Keen CL, Kim K, Tillman B, French SW, Halsted CH, LaSalle JM. Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the tx-j mouse model of Wilson disease. Epigenetics. 2014 Feb; 9(2):286-96. PMID: 24220304.
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    37. Le MD, Enbom E, Traum PK, Medici V, Halsted CH, French SW. Alcoholic liver disease patients treated with S-adenosyl-L-methionine: an in-depth look at liver morphologic data comparing pre and post treatment liver biopsies. Exp Mol Pathol. 2013 Oct; 95(2):187-91. PMID: 23886644.
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    38. Medici V, Shibata NM, Kharbanda KK, LaSalle JM, Woods R, Liu S, Engelberg JA, Devaraj S, Török NJ, Jiang JX, Havel PJ, Lönnerdal B, Kim K, Halsted CH. Wilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease. Hepatology. 2013 Feb; 57(2):555-65. PMID: 22945834.
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    39. Medici V, Halsted CH. Folate, alcohol, and liver disease. Mol Nutr Food Res. 2013 Apr; 57(4):596-606. PMID: 23136133.
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    40. Medici V. The evolving scenario of copper and fatty liver. Metab Syndr Relat Disord. 2013 Feb; 11(1):4-6. PMID: 23127162.
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    41. Catana AM, Medici V. Liver transplantation for Wilson disease. World J Hepatol. 2012 Jan 27; 4(1):5-10. PMID: 22312450.
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    42. Medici V, Virata MC, Peerson JM, Stabler SP, French SW, Gregory JF, Albanese A, Bowlus CL, Devaraj S, Panacek EA, Richards JR, Halsted CH. S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial. Alcohol Clin Exp Res. 2011 Nov; 35(11):1960-5. PMID: 22044287.
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    43. Barollo M, Medici V, D'Incà R, Banerjee A, Ingravallo G, Scarpa M, Patak S, Ruffolo C, Cardin R, Sturniolo GC. Antioxidative potential of a combined therapy of anti TNFa and Zn acetate in experimental colitis. World J Gastroenterol. 2011 Sep 28; 17(36):4099-103. PMID: 22039323.
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    44. Halsted CH, Medici V. Vitamin-dependent methionine metabolism and alcoholic liver disease. Adv Nutr. 2011 Sep; 2(5):421-7. PMID: 22332083.
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    45. Halsted CH, Medici V. Aberrant hepatic methionine metabolism and gene methylation in the pathogenesis and treatment of alcoholic steatohepatitis. Int J Hepatol. 2012; 2012:959746. PMID: 22007317.
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    46. Stanhope KL, Bremer AA, Medici V, Nakajima K, Ito Y, Nakano T, Chen G, Fong TH, Lee V, Menorca RI, Keim NL, Havel PJ. Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women. J Clin Endocrinol Metab. 2011 Oct; 96(10):E1596-605. PMID: 21849529.
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    47. Medici V, Frassoni C, Tassi L, Spreafico R, Garbelli R. Aquaporin 4 expression in control and epileptic human cerebral cortex. Brain Res. 2011 Jan 07; 1367:330-9. PMID: 20934410.
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    48. Medici V, Peerson JM, Stabler SP, French SW, Gregory JF, Virata MC, Albanese A, Bowlus CL, Devaraj S, Panacek EA, Rahim N, Richards JR, Rossaro L, Halsted CH. Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease. J Hepatol. 2010 Sep; 53(3):551-7. PMID: 20561703.
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    49. Medici V, Ali MR, Seo S, Aoki CA, Rossaro L, Kim K, Fuller WD, Vidovszky TJ, Smith W, Jiang JX, Maganti K, Havel PJ, Kamboj A, Ramsamooj R, Török NJ. Increased soluble leptin receptor levels in morbidly obese patients with insulin resistance and nonalcoholic fatty liver disease. Obesity (Silver Spring). 2010 Dec; 18(12):2268-73. PMID: 20448542.
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    50. Cope-Yokoyama S, Finegold MJ, Sturniolo GC, Kim K, Mescoli C, Rugge M, Medici V. Wilson disease: histopathological correlations with treatment on follow-up liver biopsies. World J Gastroenterol. 2010 Mar 28; 16(12):1487-94. PMID: 20333789.
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    51. Esfandiari F, Medici V, Wong DH, Jose S, Dolatshahi M, Quinlivan E, Dayal S, Lentz SR, Tsukamoto H, Zhang YH, French SW, Halsted CH. Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse. Hepatology. 2010 Mar; 51(3):932-41. PMID: 19957376.
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    52. Medici V, Sturniolo GC. Tetrathiomolybdate, a copper chelator for the treatment of Wilson disease, pulmonary fibrosis and other indications. IDrugs. 2008 Aug; 11(8):592-606. PMID: 18683094.
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    53. Medici V, Rossaro L, Wegelin JA, Kamboj A, Nakai J, Fisher K, Meyers FJ. The utility of the model for end-stage liver disease score: a reliable guide for liver transplant candidacy and, for select patients, simultaneous hospice referral. Liver Transpl. 2008 Aug; 14(8):1100-6. PMID: 18668666.
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    54. Kashani A, Landaverde C, Medici V, Rossaro L. Fluid retention in cirrhosis: pathophysiology and management. QJM. 2008 Feb; 101(2):71-85. PMID: 18184668.
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    55. Medici V, Di Leo V, Lamboglia F, Bowlus CL, Tseng SC, D'Incà R, Irato P, Burra P, Martines D, Sturniolo GC. Effect of penicillamine and zinc on iron metabolism in Wilson's disease. Scand J Gastroenterol. 2007 Dec; 42(12):1495-500. PMID: 17994470.
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    56. Amidi F, French BA, Chung D, Halsted CH, Medici V, French SW. M-30 and 4HNE are sequestered in different aggresomes in the same hepatocytes. Exp Mol Pathol. 2007 Dec; 83(3):296-300. PMID: 17963745.
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    57. D'Incà R, Pomerri F, Vettorato MG, Dal Pont E, Di Leo V, Ferronato A, Medici V, Sturniolo GC. Interaction between rifaximin and dietary fibre in patients with diverticular disease. Aliment Pharmacol Ther. 2007 Apr 01; 25(7):771-9. PMID: 17373915.
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    58. Medici V, Rossaro L, Sturniolo GC. Wilson disease--a practical approach to diagnosis, treatment and follow-up. Dig Liver Dis. 2007 Jul; 39(7):601-9. PMID: 17382611.
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    59. Medici V, Trevisan CP, Bigotto MA, D'Incà R, Martines D, Dal Pont E, Sturniolo GC. Adverse reaction after tetrathiomolybdate treatment for Wilson's disease: a case report. Mov Disord. 2006 Nov; 21(11):2030-2. PMID: 16991142.
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    60. Medici V, Trevisan CP, D'Incà R, Barollo M, Zancan L, Fagiuoli S, Martines D, Irato P, Sturniolo GC. Diagnosis and management of Wilson's disease: results of a single center experience. J Clin Gastroenterol. 2006 Nov-Dec; 40(10):936-41. PMID: 17063115.
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    61. Medici V, Mascheretti S, Croucher PJ, Stoll M, Hampe J, Grebe J, Sturniolo GC, Solberg C, Jahnsen J, Moum B, Schreiber S, Vatn MH. Extreme heterogeneity in CARD15 and DLG5 Crohn disease-associated polymorphisms between German and Norwegian populations. Eur J Hum Genet. 2006 Apr; 14(4):459-68. PMID: 16493449.
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    62. Medici V, Mirante VG, Fassati LR, Pompili M, Forti D, Del Gaudio M, Trevisan CP, Cillo U, Sturniolo GC, Fagiuoli S. Liver transplantation for Wilson's disease: The burden of neurological and psychiatric disorders. Liver Transpl. 2005 Sep; 11(9):1056-63. PMID: 16123950.
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    63. Medici V, Sturniolo GC, Santon A, D'Incà R, Bortolami M, Cardin R, Basso D, Albergoni V, Irato P. Efficacy of zinc supplementation in preventing acute hepatitis in Long-Evans Cinnamon rats. Liver Int. 2005 Aug; 25(4):888-95. PMID: 15998441.
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    64. Barollo M, D'Inca R, Scarpa M, Medici V, Cardin R, Bortolami M, Ruffolo C, Angriman I, Sturniolo GC. Effects of iron manipulation on trace elements level in a model of colitis in rats. World J Gastroenterol. 2005 Jul 28; 11(28):4396-9. PMID: 16038040.
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    65. Rosenstiel P, Agnholt J, Kelsen J, Medici V, Waetzig GH, Seegert D, Schreiber S. Differential modulation of p38 mitogen activated protein kinase and STAT3 signalling pathways by infliximab and etanercept in intestinal T cells from patients with Crohn's disease. Gut. 2005 Feb; 54(2):314-5; author reply 316-6. PMID: 15647208.
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    66. Benazzato L, D'Incà R, Grigoletto F, Perissinotto E, Medici V, Angriman I, Sturniolo GC. Prognosis of severe attacks in ulcerative colitis: effect of intensive medical treatment. Dig Liver Dis. 2004 Jul; 36(7):461-6. PMID: 15285525.
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    67. Barollo M, D'Incà R, Scarpa M, Medici V, Cardin R, Fries W, Angriman I, Sturniolo GC. Effects of iron deprivation or chelation on DNA damage in experimental colitis. Int J Colorectal Dis. 2004 Sep; 19(5):461-6. PMID: 15067556.
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    68. Santon A, Irato P, Medici V, D'Incà R, Albergoni V, Sturniolo GC. Effect and possible role of Zn treatment in LEC rats, an animal model of Wilson's disease. Biochim Biophys Acta. 2003 Jan 20; 1637(1):91-7. PMID: 12527412.
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    69. Medici V, Santon A, Sturniolo GC, D'Incà R, Giannetto S, Albergoni V, Irato P. Metallothionein and antioxidant enzymes in Long-Evans Cinnamon rats treated with zinc. Arch Toxicol. 2002 Sep; 76(9):509-16. PMID: 12242608.
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    70. Santon A, Giannetto S, Sturniolo GC, Medici V, D'Incà R, Irato P, Albergoni V. Interactions between Zn and Cu in LEC rats, an animal model of Wilson's disease. Histochem Cell Biol. 2002 Mar; 117(3):275-81. PMID: 11914925.
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