Marie Cuevas Heffern

Title(s)Assistant Professor, Chemistry
SchoolCollege of Letters and Sciences
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    Metalloendocrinology: Mapping Bioinorganic Chemistry in the Extracellular Space
    NIH R35GM133684Sep 1, 2019 - Jun 30, 2024
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The role of intestine in metabolic dysregulation in murine Wilson disease. Hepatol Commun. 2023 10 01; 7(10). Sarode GV, Mazi TA, Neier K, Shibata NM, Jospin G, Harder NHO, Caceres A, Heffern MC, Sharma AK, More SK, Dave M, Schroeder SM, Wang L, LaSalle JM, Lutsenko S, Medici V. PMID: 37695076; PMCID: PMC10497250.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Copper(II) Affects the Biochemical Behavior of Proinsulin C-peptide by Forming Ternary Complexes with Serum Albumin. J Am Chem Soc. 2023 08 02; 145(30):16726-16738. San Juan JA, Chakarawet K, He Z, Fernandez RL, Stevenson MJ, Harder NHO, Janisse SE, Wang LP, Britt RD, Heffern MC. PMID: 37486968.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Characterizing metal-biomolecule interactions by mass spectrometry. Trends Biochem Sci. 2023 09; 48(9):815-825. Janisse SE, Fernandez RL, Heffern MC. PMID: 37433704.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Plant-derived chelators and ionophores as potential therapeutics for metabolic diseases. Chem Soc Rev. 2023 Jun 06; 52(11):3927-3945. Lee VJ, Janisse SE, Heffern MC. PMID: 37203389; PMCID: PMC10281457.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. The role of intestine in metabolic dysregulation in murine Wilson disease. bioRxiv. 2023 Jan 14. Sarode GV, Mazi TA, Neier K, Shibata NM, Jospin G, Harder NHO, Heffern MC, Sharma AK, More SK, Dave M, Schroeder SM, Wang L, LaSalle JM, Lutsenko S, Medici V. PMID: 36711483; PMCID: PMC9882126.
      View in: PubMed   Mentions:
    6. Investigation of metal modulation of oxytocin structure receptor-mediated signaling. RSC Chem Biol. 2023 Feb 08; 4(2):165-172. O'Sullivan JJ, Uyeda KS, Stevenson MJ, Heffern MC. PMID: 36794023; PMCID: PMC9906307.
      View in: PubMed   Mentions:
    7. Copper-mediated oxidation of imidazopyrazinones inhibits marine luciferase activity. Luminescence. 2023 Feb; 38(2):216-220. O'Sullivan JJ, Lee VJ, Heffern MC. PMID: 36409206; PMCID: PMC10281456.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    8. Monitoring and treatment of Wilson disease: progress and challenges. Lancet Gastroenterol Hepatol. 2022 Dec; 7(12):1063-1065. Medici V, Heffern MC. PMID: 36183739.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Systematic evaluation of Copper(II)-loaded immobilized metal affinity chromatography for selective enrichment of copper-binding species in human serum and plasma. Metallomics. 2022 09 01; 14(9). Janisse SE, Sharma VA, Caceres A, Medici V, Heffern MC. PMID: 35929804; PMCID: PMC9434637.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Structure-activity assessment of flavonoids as modulators of copper transport. Front Chem. 2022; 10:972198. Lee VJ, Heffern MC. PMID: 36082200; PMCID: PMC9445161.
      View in: PubMed   Mentions: 2  
    11. Development of an ATP-independent bioluminescent probe for detection of extracellular hydrogen peroxide. Org Biomol Chem. 2022 08 10; 20(31):6231-6238. O'Sullivan JJ, Heffern MC. PMID: 35548907; PMCID: PMC9378503.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. Correction: A caged imidazopyrazinone for selective bioluminescence detection of labile extracellular copper(ii). Chem Sci. 2022 May 18; 13(19):5774. O'Sullivan JJ, Medici V, Heffern MC. PMID: 35694340; PMCID: PMC9116369.
      View in: PubMed   Mentions: 1  
    13. Fatty Acid Uptake in Liver Hepatocytes Induces Relocalization and Sequestration of Intracellular Copper. Front Mol Biosci. 2022; 9:863296. Harder NHO, Lee HP, Flood VJ, San Juan JA, Gillette SK, Heffern MC. PMID: 35480878; PMCID: PMC9036104.
      View in: PubMed   Mentions: 1  
    14. Quantifying the Binding Interactions Between Cu(II) and Peptide Residues in the Presence and Absence of Chromophores. J Vis Exp. 2022 04 05; (182). Choi S, San Juan JA, Heffern MC, Stevenson MJ. PMID: 35467664; PMCID: PMC10405695.
      View in: PubMed   Mentions:    Fields:    
    15. A caged imidazopyrazinone for selective bioluminescence detection of labile extracellular copper(ii). Chem Sci. 2022 Apr 13; 13(15):4352-4363. O'Sullivan JJ, Medici V, Heffern MC. PMID: 35509459; PMCID: PMC9006956.
      View in: PubMed   Mentions: 4  
    16. Adsorption of perfluorooctanoic acid from water by pH-modulated Brönsted acid and base sites in mesoporous hafnium oxide ceramics. iScience. 2022 Apr 15; 25(4):104138. Hussain FA, Janisse SE, Heffern MC, Kinyua M, Velázquez JM. PMID: 35402881; PMCID: PMC8987376.
      View in: PubMed   Mentions: 2  
    17. Effects of Dietary Glucose and Fructose on Copper, Iron, and Zinc Metabolism Parameters in Humans. Nutrients. 2020 Aug 25; 12(9). Harder NHO, Hieronimus B, Stanhope KL, Shibata NM, Lee V, Nunez MV, Keim NL, Bremer A, Havel PJ, Heffern MC, Medici V. PMID: 32854403; PMCID: PMC7551875.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    18. What Comes Next? Simple Practices to Improve Diversity in Science. ACS Cent Sci. 2020 Aug 26; 6(8):1231-1240. Fadeyi OO, Heffern MC, Johnson SS, Townsend SD. PMID: 32875063; PMCID: PMC7453409.
      View in: PubMed   Mentions: 9  
    19. Detecting liver disease via an endogenous pigment. Nat Biomed Eng. 2020 08; 4(8):761-762. O'Sullivan JJ, Harder NHO, Heffern MC. PMID: 32778783.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Elucidation of a Copper Binding Site in Proinsulin C-peptide and Its Implications for Metal-Modulated Activity. Inorg Chem. 2020 Jul 06; 59(13):9339-9349. Stevenson MJ, Janisse SE, Tao L, Neil RL, Pham QD, Britt RD, Heffern MC. PMID: 32510934; PMCID: PMC8023225.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    21. Effects of Copper Chelation on BRAFV600E Positive Colon Carcinoma Cells. Cancers (Basel). 2019 May 12; 11(5). Baldari S, Di Rocco G, Heffern MC, Su TA, Chang CJ, Toietta G. PMID: 31083627; PMCID: PMC6562624.
      View in: PubMed   Mentions: 22  
    22. Analysis of Metal Effects on C-Peptide Structure and Internalization. Chembiochem. 2019 10 01; 20(19):2447-2453. Stevenson MJ, Farran IC, Uyeda KS, San Juan JA, Heffern MC. PMID: 31074079.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Metal-dependent hormone function: the emerging interdisciplinary field of metalloendocrinology. Metallomics. 2019 01 23; 11(1):85-110. Stevenson MJ, Uyeda KS, Harder NHO, Heffern MC. PMID: 30270362; PMCID: PMC10249669.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    24. Acinetobacter baumannii OxyR Regulates the Transcriptional Response to Hydrogen Peroxide. Infect Immun. 2019 01; 87(1). Juttukonda LJ, Green ER, Lonergan ZR, Heffern MC, Chang CJ, Skaar EP. PMID: 30297527; PMCID: PMC6300632.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    25. A Modular Ionophore Platform for Liver-Directed Copper Supplementation in Cells and Animals. J Am Chem Soc. 2018 10 24; 140(42):13764-13774. Su TA, Shihadih DS, Cao W, Detomasi TC, Heffern MC, Jia S, Stahl A, Chang CJ. PMID: 30351140; PMCID: PMC6465169.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    26. Sounding Out Dysfunctional Oxygen Metabolism: A Small-Molecule Probe for Photoacoustic Imaging of Hypoxia. Biochemistry. 2018 02 13; 57(6):893-894. Stevenson MJ, Heffern MC. PMID: 29363954.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    27. Diversifying the Glowing Bioluminescent Toolbox. ACS Cent Sci. 2017 Dec 27; 3(12):1234-1236. Heffern MC. PMID: 29296662; PMCID: PMC5746852.
      View in: PubMed   Mentions: 3  
    28. In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection. Proc Natl Acad Sci U S A. 2017 11 28; 114(48):12669-12674. Aron AT, Heffern MC, Lonergan ZR, Vander Wal MN, Blank BR, Spangler B, Zhang Y, Park HM, Stahl A, Renslo AR, Skaar EP, Chang CJ. PMID: 29138321; PMCID: PMC5715752.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    29. In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):14219-14224. Heffern MC, Park HM, Au-Yeung HY, Van de Bittner GC, Ackerman CM, Stahl A, Chang CJ. PMID: 27911810; PMCID: PMC5167165.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    30. Tuning cobalt(III) Schiff base complexes as activated protein inhibitors. Inorg Chem. 2015 Sep 21; 54(18):9066-74. Heffern MC, Reichova V, Coomes JL, Harney AS, Bajema EA, Meade TJ. PMID: 26331337; PMCID: PMC4638226.
      View in: PubMed   Mentions: 5     Fields:    
    31. Modulation of amyloid-β aggregation by histidine-coordinating Cobalt(III) Schiff base complexes. Chembiochem. 2014 Jul 21; 15(11):1584-9. Heffern MC, Velasco PT, Matosziuk LM, Coomes JL, Karras C, Ratner MA, Klein WL, Eckermann AL, Meade TJ. PMID: 24961930; PMCID: PMC4166533.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    32. Lanthanide probes for bioresponsive imaging. Chem Rev. 2014 Apr 23; 114(8):4496-539. Heffern MC, Matosziuk LM, Meade TJ. PMID: 24328202; PMCID: PMC3999228.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimals
    33. Spectroscopic elucidation of the inhibitory mechanism of Cys2His2 zinc finger transcription factors by cobalt(III) Schiff base complexes. Chemistry. 2013 Dec 09; 19(50):17043-53. Heffern MC, Kurutz JW, Meade TJ. PMID: 24203451; PMCID: PMC3910297.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    34. Structural optimization of Zn(II)-activated magnetic resonance imaging probes. Inorg Chem. 2013 Nov 04; 52(21):12250-61. Matosziuk LM, Leibowitz JH, Heffern MC, MacRenaris KW, Ratner MA, Meade TJ. PMID: 23777423; PMCID: PMC3805786.
      View in: PubMed   Mentions: 10     Fields:    
    35. Rational design of [Co(acacen)L2]+ inhibitors of protein function. Dalton Trans. 2013 Mar 21; 42(11):4002-12. Matosziuk LM, Holbrook RJ, Manus LM, Heffern MC, Ratner MA, Meade TJ. PMID: 23340849; PMCID: PMC3581327.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    36. Axial ligand exchange of N-heterocyclic cobalt(III) Schiff base complexes: molecular structure and NMR solution dynamics. Inorg Chem. 2013 Jan 18; 52(2):1069-76. Manus LM, Holbrook RJ, Atesin TA, Heffern MC, Harney AS, Eckermann AL, Meade TJ. PMID: 23282130; PMCID: PMC3554264.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    37. Cobalt derivatives as promising therapeutic agents. Curr Opin Chem Biol. 2013 Apr; 17(2):189-96. Heffern MC, Yamamoto N, Holbrook RJ, Eckermann AL, Meade TJ. PMID: 23270779; PMCID: PMC3622775.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    38. Synapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodies. ACS Chem Neurosci. 2012 Nov 21; 3(11):972-81. Velasco PT, Heffern MC, Sebollela A, Popova IA, Lacor PN, Lee KB, Sun X, Tiano BN, Viola KL, Eckermann AL, Meade TJ, Klein WL. PMID: 23173076; PMCID: PMC3503444.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    39. Specific inhibition of the transcription factor Ci by a cobalt(III) Schiff base-DNA conjugate. Mol Pharm. 2012 Feb 06; 9(2):325-33. Hurtado RR, Harney AS, Heffern MC, Holbrook RJ, Holmgren RA, Meade TJ. PMID: 22214326; PMCID: PMC3313626.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    40. Effect of surface modification on the dielectric properties of BaTiO3 nanocrystals. Langmuir. 2010 Apr 06; 26(7):5067-71. Beier CW, Cuevas MA, Brutchey RL. PMID: 20039602.
      View in: PubMed   Mentions: 1     Fields:    
    41. Room-temperature synthetic pathways to barium titanate nanocrystals. Small. 2008 Dec; 4(12):2102-6. Beier CW, Cuevas MA, Brutchey RL. PMID: 19016495.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
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