Marie Heffern • UC Davis Profiles

Marie Cuevas Heffern

Title(s)	Assistant Professor, Chemistry
School	College of Letters and Sciences
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Research

Research Activities and Funding

Metalloendocrinology: Mapping Bioinorganic Chemistry in the Extracellular Space
NIH R35GM133684Sep 1, 2019 - Jun 30, 2024
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

The role of intestine in metabolic dysregulation in murine Wilson disease. Hepatol Commun. 2023 10 01; 7(10). Sarode GV, Mazi TA, Neier K, Shibata NM, Jospin G, Harder NHO, Caceres A, Heffern MC, Sharma AK, More SK, Dave M, Schroeder SM, Wang L, LaSalle JM, Lutsenko S, Medici V. PMID: 37695076; PMCID: PMC10497250.

View in: PubMed Mentions: Fields:
Gas Gastroenterology
Translation:Animals
Copper(II) Affects the Biochemical Behavior of Proinsulin C-peptide by Forming Ternary Complexes with Serum Albumin. J Am Chem Soc. 2023 08 02; 145(30):16726-16738. San Juan JA, Chakarawet K, He Z, Fernandez RL, Stevenson MJ, Harder NHO, Janisse SE, Wang LP, Britt RD, Heffern MC. PMID: 37486968.

View in: PubMed Mentions: Fields:
Che Chemistry
Translation:Humans Cells
Characterizing metal-biomolecule interactions by mass spectrometry. Trends Biochem Sci. 2023 09; 48(9):815-825. Janisse SE, Fernandez RL, Heffern MC. PMID: 37433704.

View in: PubMed Mentions: Fields:
Bio Biochemistry
Translation:Humans
Plant-derived chelators and ionophores as potential therapeutics for metabolic diseases. Chem Soc Rev. 2023 Jun 06; 52(11):3927-3945. Lee VJ, Janisse SE, Heffern MC. PMID: 37203389; PMCID: PMC10281457.

View in: PubMed Mentions: Fields:
Che Chemistry
Translation:Animals
The role of intestine in metabolic dysregulation in murine Wilson disease. bioRxiv. 2023 Jan 14. Sarode GV, Mazi TA, Neier K, Shibata NM, Jospin G, Harder NHO, Heffern MC, Sharma AK, More SK, Dave M, Schroeder SM, Wang L, LaSalle JM, Lutsenko S, Medici V. PMID: 36711483; PMCID: PMC9882126.

View in: PubMed Mentions:
Investigation of metal modulation of oxytocin structure receptor-mediated signaling. RSC Chem Biol. 2023 Feb 08; 4(2):165-172. O'Sullivan JJ, Uyeda KS, Stevenson MJ, Heffern MC. PMID: 36794023; PMCID: PMC9906307.

View in: PubMed Mentions:
Copper-mediated oxidation of imidazopyrazinones inhibits marine luciferase activity. Luminescence. 2023 Feb; 38(2):216-220. O'Sullivan JJ, Lee VJ, Heffern MC. PMID: 36409206; PMCID: PMC10281456.

View in: PubMed Mentions: Fields:
Bio Biochemistry Bio Biophysics
Translation:Cells
Monitoring and treatment of Wilson disease: progress and challenges. Lancet Gastroenterol Hepatol. 2022 Dec; 7(12):1063-1065. Medici V, Heffern MC. PMID: 36183739.

View in: PubMed Mentions: 1 Fields:
Gas Gastroenterology
Translation:Humans
Systematic evaluation of Copper(II)-loaded immobilized metal affinity chromatography for selective enrichment of copper-binding species in human serum and plasma. Metallomics. 2022 09 01; 14(9). Janisse SE, Sharma VA, Caceres A, Medici V, Heffern MC. PMID: 35929804; PMCID: PMC9434637.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Humans
Structure-activity assessment of flavonoids as modulators of copper transport. Front Chem. 2022; 10:972198. Lee VJ, Heffern MC. PMID: 36082200; PMCID: PMC9445161.

View in: PubMed Mentions: 2
Development of an ATP-independent bioluminescent probe for detection of extracellular hydrogen peroxide. Org Biomol Chem. 2022 08 10; 20(31):6231-6238. O'Sullivan JJ, Heffern MC. PMID: 35548907; PMCID: PMC9378503.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Correction: A caged imidazopyrazinone for selective bioluminescence detection of labile extracellular copper(ii). Chem Sci. 2022 May 18; 13(19):5774. O'Sullivan JJ, Medici V, Heffern MC. PMID: 35694340; PMCID: PMC9116369.

View in: PubMed Mentions: 1
Fatty Acid Uptake in Liver Hepatocytes Induces Relocalization and Sequestration of Intracellular Copper. Front Mol Biosci. 2022; 9:863296. Harder NHO, Lee HP, Flood VJ, San Juan JA, Gillette SK, Heffern MC. PMID: 35480878; PMCID: PMC9036104.

View in: PubMed Mentions: 1
Quantifying the Binding Interactions Between Cu(II) and Peptide Residues in the Presence and Absence of Chromophores. J Vis Exp. 2022 04 05; (182). Choi S, San Juan JA, Heffern MC, Stevenson MJ. PMID: 35467664; PMCID: PMC10405695.

View in: PubMed Mentions: Fields:
Bio Biology Med Medicine (General)
A caged imidazopyrazinone for selective bioluminescence detection of labile extracellular copper(ii). Chem Sci. 2022 Apr 13; 13(15):4352-4363. O'Sullivan JJ, Medici V, Heffern MC. PMID: 35509459; PMCID: PMC9006956.

View in: PubMed Mentions: 4
Adsorption of perfluorooctanoic acid from water by pH-modulated Brönsted acid and base sites in mesoporous hafnium oxide ceramics. iScience. 2022 Apr 15; 25(4):104138. Hussain FA, Janisse SE, Heffern MC, Kinyua M, Velázquez JM. PMID: 35402881; PMCID: PMC8987376.

View in: PubMed Mentions: 2
Effects of Dietary Glucose and Fructose on Copper, Iron, and Zinc Metabolism Parameters in Humans. Nutrients. 2020 Aug 25; 12(9). Harder NHO, Hieronimus B, Stanhope KL, Shibata NM, Lee V, Nunez MV, Keim NL, Bremer A, Havel PJ, Heffern MC, Medici V. PMID: 32854403; PMCID: PMC7551875.

View in: PubMed Mentions: 8 Fields:
Nut Nutritional Sciences
Translation:Humans
What Comes Next? Simple Practices to Improve Diversity in Science. ACS Cent Sci. 2020 Aug 26; 6(8):1231-1240. Fadeyi OO, Heffern MC, Johnson SS, Townsend SD. PMID: 32875063; PMCID: PMC7453409.

View in: PubMed Mentions: 9
Detecting liver disease via an endogenous pigment. Nat Biomed Eng. 2020 08; 4(8):761-762. O'Sullivan JJ, Harder NHO, Heffern MC. PMID: 32778783.

View in: PubMed Mentions: 1 Fields:
Bio Biomedical Engineering
Translation:Humans
Elucidation of a Copper Binding Site in Proinsulin C-peptide and Its Implications for Metal-Modulated Activity. Inorg Chem. 2020 Jul 06; 59(13):9339-9349. Stevenson MJ, Janisse SE, Tao L, Neil RL, Pham QD, Britt RD, Heffern MC. PMID: 32510934; PMCID: PMC8023225.

View in: PubMed Mentions: 1 Fields:
Che Chemistry
Translation:Cells
Effects of Copper Chelation on BRAFV600E Positive Colon Carcinoma Cells. Cancers (Basel). 2019 May 12; 11(5). Baldari S, Di Rocco G, Heffern MC, Su TA, Chang CJ, Toietta G. PMID: 31083627; PMCID: PMC6562624.

View in: PubMed Mentions: 22
Analysis of Metal Effects on C-Peptide Structure and Internalization. Chembiochem. 2019 10 01; 20(19):2447-2453. Stevenson MJ, Farran IC, Uyeda KS, San Juan JA, Heffern MC. PMID: 31074079.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry
Translation:Humans Cells
Metal-dependent hormone function: the emerging interdisciplinary field of metalloendocrinology. Metallomics. 2019 01 23; 11(1):85-110. Stevenson MJ, Uyeda KS, Harder NHO, Heffern MC. PMID: 30270362; PMCID: PMC10249669.

View in: PubMed Mentions: 7 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Acinetobacter baumannii OxyR Regulates the Transcriptional Response to Hydrogen Peroxide. Infect Immun. 2019 01; 87(1). Juttukonda LJ, Green ER, Lonergan ZR, Heffern MC, Chang CJ, Skaar EP. PMID: 30297527; PMCID: PMC6300632.

View in: PubMed Mentions: 31 Fields:
All Allergy and Immunology Com Communicable Diseases
Translation:Animals Cells
A Modular Ionophore Platform for Liver-Directed Copper Supplementation in Cells and Animals. J Am Chem Soc. 2018 10 24; 140(42):13764-13774. Su TA, Shihadih DS, Cao W, Detomasi TC, Heffern MC, Jia S, Stahl A, Chang CJ. PMID: 30351140; PMCID: PMC6465169.

View in: PubMed Mentions: 15 Fields:
Che Chemistry
Translation:Animals
Sounding Out Dysfunctional Oxygen Metabolism: A Small-Molecule Probe for Photoacoustic Imaging of Hypoxia. Biochemistry. 2018 02 13; 57(6):893-894. Stevenson MJ, Heffern MC. PMID: 29363954.

View in: PubMed Mentions: Fields:
Bio Biochemistry
Translation:Humans Animals
Diversifying the Glowing Bioluminescent Toolbox. ACS Cent Sci. 2017 Dec 27; 3(12):1234-1236. Heffern MC. PMID: 29296662; PMCID: PMC5746852.

View in: PubMed Mentions: 3
In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection. Proc Natl Acad Sci U S A. 2017 11 28; 114(48):12669-12674. Aron AT, Heffern MC, Lonergan ZR, Vander Wal MN, Blank BR, Spangler B, Zhang Y, Park HM, Stahl A, Renslo AR, Skaar EP, Chang CJ. PMID: 29138321; PMCID: PMC5715752.

View in: PubMed Mentions: 44 Fields:
Sci Science
Translation:Animals Cells
In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):14219-14224. Heffern MC, Park HM, Au-Yeung HY, Van de Bittner GC, Ackerman CM, Stahl A, Chang CJ. PMID: 27911810; PMCID: PMC5167165.

View in: PubMed Mentions: 60 Fields:
Sci Science
Translation:Animals
Tuning cobalt(III) Schiff base complexes as activated protein inhibitors. Inorg Chem. 2015 Sep 21; 54(18):9066-74. Heffern MC, Reichova V, Coomes JL, Harney AS, Bajema EA, Meade TJ. PMID: 26331337; PMCID: PMC4638226.

View in: PubMed Mentions: 5 Fields:
Che Chemistry
Modulation of amyloid-β aggregation by histidine-coordinating Cobalt(III) Schiff base complexes. Chembiochem. 2014 Jul 21; 15(11):1584-9. Heffern MC, Velasco PT, Matosziuk LM, Coomes JL, Karras C, Ratner MA, Klein WL, Eckermann AL, Meade TJ. PMID: 24961930; PMCID: PMC4166533.

View in: PubMed Mentions: 8 Fields:
Bio Biochemistry
Translation:Cells
Lanthanide probes for bioresponsive imaging. Chem Rev. 2014 Apr 23; 114(8):4496-539. Heffern MC, Matosziuk LM, Meade TJ. PMID: 24328202; PMCID: PMC3999228.

View in: PubMed Mentions: 134 Fields:
Che Chemistry
Translation:Humans Animals
Spectroscopic elucidation of the inhibitory mechanism of Cys2His2 zinc finger transcription factors by cobalt(III) Schiff base complexes. Chemistry. 2013 Dec 09; 19(50):17043-53. Heffern MC, Kurutz JW, Meade TJ. PMID: 24203451; PMCID: PMC3910297.

View in: PubMed Mentions: 11 Fields:
Che Chemistry
Translation:Cells
Structural optimization of Zn(II)-activated magnetic resonance imaging probes. Inorg Chem. 2013 Nov 04; 52(21):12250-61. Matosziuk LM, Leibowitz JH, Heffern MC, MacRenaris KW, Ratner MA, Meade TJ. PMID: 23777423; PMCID: PMC3805786.

View in: PubMed Mentions: 10 Fields:
Che Chemistry
Rational design of [Co(acacen)L2]+ inhibitors of protein function. Dalton Trans. 2013 Mar 21; 42(11):4002-12. Matosziuk LM, Holbrook RJ, Manus LM, Heffern MC, Ratner MA, Meade TJ. PMID: 23340849; PMCID: PMC3581327.

View in: PubMed Mentions: 6 Fields:
Che Chemistry
Translation:Cells
Axial ligand exchange of N-heterocyclic cobalt(III) Schiff base complexes: molecular structure and NMR solution dynamics. Inorg Chem. 2013 Jan 18; 52(2):1069-76. Manus LM, Holbrook RJ, Atesin TA, Heffern MC, Harney AS, Eckermann AL, Meade TJ. PMID: 23282130; PMCID: PMC3554264.

View in: PubMed Mentions: 13 Fields:
Che Chemistry
Translation:Cells
Cobalt derivatives as promising therapeutic agents. Curr Opin Chem Biol. 2013 Apr; 17(2):189-96. Heffern MC, Yamamoto N, Holbrook RJ, Eckermann AL, Meade TJ. PMID: 23270779; PMCID: PMC3622775.

View in: PubMed Mentions: 33 Fields:
Bio Biochemistry
Translation:Humans
Synapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodies. ACS Chem Neurosci. 2012 Nov 21; 3(11):972-81. Velasco PT, Heffern MC, Sebollela A, Popova IA, Lacor PN, Lee KB, Sun X, Tiano BN, Viola KL, Eckermann AL, Meade TJ, Klein WL. PMID: 23173076; PMCID: PMC3503444.

View in: PubMed Mentions: 24 Fields:
Neu Neurology
Translation:Humans Cells
Specific inhibition of the transcription factor Ci by a cobalt(III) Schiff base-DNA conjugate. Mol Pharm. 2012 Feb 06; 9(2):325-33. Hurtado RR, Harney AS, Heffern MC, Holbrook RJ, Holmgren RA, Meade TJ. PMID: 22214326; PMCID: PMC3313626.

View in: PubMed Mentions: 23 Fields:
Mol Molecular Biology Pha Pharmacology
Translation:Humans Animals Cells
Effect of surface modification on the dielectric properties of BaTiO3 nanocrystals. Langmuir. 2010 Apr 06; 26(7):5067-71. Beier CW, Cuevas MA, Brutchey RL. PMID: 20039602.

View in: PubMed Mentions: 1 Fields:
Che Chemistry
Room-temperature synthetic pathways to barium titanate nanocrystals. Small. 2008 Dec; 4(12):2102-6. Beier CW, Cuevas MA, Brutchey RL. PMID: 19016495.

View in: PubMed Mentions: 1 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Cells