Elena A Goncharova

Title(s)Professor, Pulmonary, Critical Care, and Sleep Medicine
SchoolSchool of Medicine
ORCID ORCID Icon0000-0001-7118-6752 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Moscow State University, Russian Academy of Science, Moscow, RussiaPhD2000Biology
    University of Pennsylvania, Pihladelphia, PA2005Postdoctoral training in Signal Transduction and Smooth Muscle Biology
    Collapse Awards and Honors
    American Heart Association (AHA)2023The AHA Fellow designation
    Expertscape 2021an Expertscape Expert in Pulmonary Arterial Hypertension
    American Thoracic Society (ATS)2020The ATS Fellow designation
    American Thoracic Society (ATS)2019The AJRCCM Eminent Reviewer Award
    University of Pittsburgh2014VMI-HVI Innovator Award
    The LAM Foundation2013LAM Foundation Francis G. Byrnes Conference Award
    University of Pennsylvania Department of Medicine2012Robert Austrian Award in Bench Research
    American Lung Association2011American Lung Association Biomedical Research Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    LDHA-lactate signaling in pulmonary arterial hypertension
    nih/nhlbi R01HL172488Dec 1, 2023 - Nov 30, 2027
    Description: Role: Principal Investigator
    HIPK2 signaling in pulmonary arterial hypertension
    nih/nhlbi R01HL166932Feb 20, 2023 - Jan 31, 2028
    Role: co-I, subcontract PI
    Mitochondrial dysfunction in pulmonary hypertension
    NIH/NHLBI R01HL160666Aug 25, 2022 - Jun 30, 2026
    Role: co-I, subcontract PI
    GATA-6 in pulmonary arterial hypertension
    NIH/NHLBI R01HL150638Mar 5, 2020 - Jan 31, 2024
    Role: M Principal Investigator
    Endothelial Toll-like Receptor 3 in the pathogenesis and therapy of Pulmonary Arterial Hypertension
    NIH/NHLBI R01HL139881Jan 1, 2019 - Dec 21, 2023
    Role: co-I, subcontract PI
    HIPPO Signaling in Pulmonary Arterial Hypertension
    NIH R01HL130261Feb 15, 2016 - Apr 30, 2024
    Role: Principal Investigator
    TSC2 Signaling in Pulmonary Arterial Hypertension
    NIH R01HL113178Sep 1, 2012 - Mar 31, 2022
    Role: Principal Investigator
    Training in Comparative Lung Biology and Medicine
    NIH/NHLBI T32HL007013Jul 1, 1975 - Jul 31, 2024
    Role: co-I

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol. 2024 Jun 11. Kudryashova TV, Zaitsev SV, Jiang L, Buckley BJ, McGuckin JP, Goncharov D, Zhyvylo I, Lin D, Newcomb G, Piper B, Bogamuwa S, Saiyed A, Teos L, Pena A, Ranson M, Greenland JR, Wolters PJ, Kelso MJ, Poncz M, DeLisser HM, Cines DB, Goncharova EA, Farkas L, Stepanova V. PMID: 38860847.
      View in: PubMed   Mentions:    Fields:    
    2. What Is All of the Hype About? Hypusine Signaling as a Driver of Pulmonary Hypertension. Am J Respir Crit Care Med. 2024 Jun 01; 209(11):1298-1300. Kudryashova TV, Jiang L, Goncharova EA. PMID: 38412504; PMCID: PMC11146570.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Skeletal Muscle SIRT3 Deficiency Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction. Circulation. 2024 May 28. Jheng JR, Bai Y, Noda K, Huot JR, Cook T, Fisher A, Chen YY, Goncharov DA, Goncharova EA, Simon MA, Zhang Y, Forman DE, Rojas M, Machado RF, Auwerx J, Gladwin MT, Lai YC. PMID: 38804138.
      View in: PubMed   Mentions:    Fields:    
    4. New Kid on the Block: GLI1+ Cells and Pulmonary Arterioles Neomuscularization. Circ Res. 2024 May 24; 134(11):1402-1404. Al Ghouleh I, Pulgarin Rocha A, Goncharova EA. PMID: 38781304; PMCID: PMC11125530.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. Restoration of Lactobacillus johnsonii and Enterococcus faecalis Caused the Elimination of Tritrichomonas sp. in a Model of Antibiotic-Induced Dysbiosis. Int J Mol Sci. 2024 May 07; 25(10). Makusheva Y, Goncharova E, Bets V, Korel A, Arzhanova E, Litvinova E. PMID: 38791132; PMCID: PMC11120941.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. VIEWING PULMONARY HYPERTENSION THROUGH A PEDIATRIC LENS. Eur Respir J. 2024 Apr 04. Agarwal S, Fineman J, Cornfield DN, Alvira CM, Zamanian RT, Goss K, Yuan K, Bonnet S, Boucherat O, Pullamsetti S, Alcázar MA, Goncharova E, Kudryashova TV, Nicolls MR, de Jesús Pérez V. PMID: 38575157.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension. J Clin Invest. 2024 Feb 01; 134(3). Piper B, Bogamuwa S, Hossain T, Farkas D, Rosas L, Green AC, Newcomb G, Sun N, Ovando-Ricardez JA, Horowitz JC, Bhagwani AR, Yang H, Kudryashova TV, Rojas M, Mora AL, Yan P, Mallampalli RK, Goncharova EA, Eckmann DM, Farkas L. PMID: 38015641; PMCID: PMC10836802.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    8. PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hypertension. bioRxiv. 2023 Sep 22. Kudryashova TV, Zaitsev S, Jiang L, Buckley BJ, McGuckin JP, Goncharov D, Zhyvylo I, Lin D, Newcomb G, Piper B, Bogamuwa S, Saiyed A, Teos L, Ranson M, Wolters PJ, Kelso MJ, Poncz M, DeLisser HM, Cines DB, Goncharova EA, Farkas L, Stepanova V. PMID: 37790328; PMCID: PMC10542168.
      View in: PubMed   Mentions:
    9. Too hot? Too cold? Wnt signalling in pulmonary arterial hypertension: can we treat it "just right"? Eur Respir J. 2023 06; 61(6). Goncharova EA, Kudryashova TV, Pullamsetti SS. PMID: 37290809.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. UnWNTing the Heart: Targeting WNT Signaling in Pulmonary Arterial Hypertension. Circ Res. 2023 05 26; 132(11):1486-1488. Goncharova EA, Kudryashova TV, de Jesus Perez VA, Rafikova O. PMID: 37228239; PMCID: PMC10213998.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension. Sci Rep. 2023 04 22; 13(1):6593. Toyama T, Kudryashova TV, Ichihara A, Lenna S, Looney A, Shen Y, Jiang L, Teos L, Avolio T, Lin D, Kaplan U, Marden G, Dambal V, Goncharov D, Delisser H, Lafyatis R, Seta F, Goncharova EA, Trojanowska M. PMID: 37087509; PMCID: PMC10122657.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4-Human Leukocyte Antigen-DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension. J Am Heart Assoc. 2023 04 04; 12(7):e027894. Hafeez N, Kirillova A, Yue Y, Rao RJ, Kelly NJ, El Khoury W, Al Aaraj Y, Tai YY, Handen A, Tang Y, Jiang D, Wu T, Zhang Y, McNamara D, Kudryashova TV, Goncharova EA, Goncharov D, Bertero T, Nouraie M, Li G, Sun W, Chan SY. PMID: 36974749; PMCID: PMC10122886.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension. bioRxiv. 2023 Feb 06. Piper B, Bogamuwa S, Hossain T, Farkas D, Rosas L, Green A, Newcomb G, Sun N, Horowitz JC, Bhagwani AR, Yang H, Kudryashova TV, Rojas M, Mora AL, Yan P, Mallampalli RK, Goncharova EA, Eckmann DM, Farkas L. PMID: 36778418; PMCID: PMC9915659.
      View in: PubMed   Mentions:
    14. Editorial: Pulmonary hypertension in the modern era: Science and clinical practice, Volume II. Front Med (Lausanne). 2023; 10:1136157. Bogaard HJ, Goncharova EA, de Jesus Perez VA. PMID: 36814774; PMCID: PMC9939812.
      View in: PubMed   Mentions:
    15. A role for Toll-like receptor 3 in lung vascular remodeling associated with SARS-CoV-2 infection. bioRxiv. 2023 Jan 25. Farkas D, Bogamuwa S, Piper B, Newcomb G, Gunturu P, Bednash JS, Londino JD, Elhance A, Nho R, Mejia OR, Yount JS, Horowitz JC, Goncharova EA, Mallampalli RK, Robinson RT, Farkas L. PMID: 36747676; PMCID: PMC9900759.
      View in: PubMed   Mentions:
    16. A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3. iScience. 2023 Feb 17; 26(2):105935. Bhagwani AR, Ali M, Piper B, Liu M, Hudson J, Kelly N, Bogamuwa S, Yang H, Londino JD, Bednash JS, Farkas D, Mallampalli RK, Nicolls MR, Ryan JJ, Thompson AAR, Chan SY, Gomez D, Goncharova EA, Farkas L. PMID: 36685041; PMCID: PMC9852960.
      View in: PubMed   Mentions: 3  
    17. mTOR Signaling Network in Cell Biology and Human Disease. Int J Mol Sci. 2022 Dec 18; 23(24). Yu JJ, Goncharova EA. PMID: 36555783; PMCID: PMC9787689.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension. Sci Signal. 2022 12 06; 15(763):eabn2743. Shen Y, Goncharov DA, Pena A, Baust J, Chavez Barragan A, Ray A, Rode A, Bachman TN, Chang B, Jiang L, Dieffenbach P, Fredenburgh LE, Rojas M, DeLisser H, Mora AL, Kudryashova TV, Goncharova EA. PMID: 36473049; PMCID: PMC9869933.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. MonOrail to Cure? Targeting Orai1 to Reverse Pulmonary Arterial Hypertension. Circ Res. 2022 10 14; 131(9):728-730. Kudryashova TV, Goncharova EA. PMID: 36252052; PMCID: PMC9586488.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    20. Circling In on Pulmonary Arterial Hypertension: Is It Time to Consider Circular RNA circ_0016070 as a Biomarker and Target for Therapy? J Am Heart Assoc. 2022 07 19; 11(14):e026798. Farkas L, Goncharova EA. PMID: 35861847; PMCID: PMC9707829.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Stem Cell-derived Nanovesicles for the Treatment of Pulmonary Hypertension: Are We There Yet? Am J Respir Cell Mol Biol. 2022 07; 67(1):3-5. Goncharova EA, Farkas L. PMID: 35522729; PMCID: PMC9273228.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    22. Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary Hypertension. Front Med (Lausanne). 2022; 9:886868. Jiang L, Goncharov DA, Shen Y, Lin D, Chang B, Pena A, DeLisser H, Goncharova EA, Kudryashova TV. PMID: 35836951; PMCID: PMC9274086.
      View in: PubMed   Mentions: 4  
    23. Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival. Circ Res. 2022 03 04; 130(5):760-778. Kudryashova TV, Dabral S, Nayakanti S, Ray A, Goncharov DA, Avolio T, Shen Y, Rode A, Pena A, Jiang L, Lin D, Baust J, Bachman TN, Graumann J, Ruppert C, Guenther A, Schmoranzer M, Grobs Y, Eve Lemay S, Tremblay E, Breuils-Bonnet S, Boucherat O, Mora AL, DeLisser H, Zhao J, Zhao Y, Bonnet S, Seeger W, Pullamsetti SS, Goncharova EA. PMID: 35124974; PMCID: PMC8897250.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    24. The Effects of Healthy Aging on Right Ventricular Structure and Biomechanical Properties: A Pilot Study. Front Med (Lausanne). 2021; 8:751338. Sharifi Kia D, Shen Y, Bachman TN, Goncharova EA, Kim K, Simon MA. PMID: 35083230; PMCID: PMC8784691.
      View in: PubMed   Mentions: 5  
    25. Matrix Metalloproteinase-8 in Pulmonary Hypertension: The Sheep in the Wolf's Skin? Am J Respir Crit Care Med. 2021 12 15; 204(12):1361-1363. Goncharova EA, Kudryashova TV, Maroli G, Pullamsetti SS. PMID: 34644511; PMCID: PMC8865723.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    26. Editorial: Pulmonary Hypertension in the Modern Era: Science and Clinical Practice. Front Med (Lausanne). 2021; 8:785181. Goncharova EA, Bogaard HJ, de Jesus Perez VA. PMID: 34778329; PMCID: PMC8581044.
      View in: PubMed   Mentions:
    27. Notch2 suppression mimicking changes in human pulmonary hypertension modulates Notch1 and promotes endothelial cell proliferation. Am J Physiol Heart Circ Physiol. 2021 09 01; 321(3):H542-H557. Sahoo S, Li Y, de Jesus D, Sembrat J, Rojas MM, Goncharova E, Cifuentes-Pagano E, Straub AC, Pagano PJ. PMID: 34296965; PMCID: PMC8461839.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    28. Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction. Circulation. 2021 08 24; 144(8):615-637. Satoh T, Wang L, Espinosa-Diez C, Wang B, Hahn SA, Noda K, Rochon ER, Dent MR, Levine AR, Baust JJ, Wyman S, Wu YL, Triantafyllou GA, Tang Y, Reynolds M, Shiva S, Hilaire CS, Gomez D, Goncharov DA, Goncharova EA, Chan SY, Straub AC, Lai YC, McTiernan CF, Gladwin MT. PMID: 34157861; PMCID: PMC8384699.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    29. Yes-Associated Protein (Yap) Is Up-Regulated in Heart Failure and Promotes Cardiac Fibroblast Proliferation. Int J Mol Sci. 2021 Jun 07; 22(11). Sharifi-Sanjani M, Berman M, Goncharov D, Alhamaydeh M, Avolio TG, Baust J, Chang B, Kobir A, Ross M, St Croix C, Nouraie SM, McTiernan CF, Moravec CS, Goncharova E, Al Ghouleh I. PMID: 34200497; PMCID: PMC8201133.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    30. Wilson Disease: Intersecting DNA Methylation and Histone Acetylation Regulation of Gene Expression in a Mouse Model of Hepatic Copper Accumulation. Cell Mol Gastroenterol Hepatol. 2021; 12(4):1457-1477. Sarode GV, Neier K, Shibata NM, Shen Y, Goncharov DA, Goncharova EA, Mazi TA, Joshi N, Settles ML, LaSalle JM, Medici V. PMID: 34098115; PMCID: PMC8487080.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    31. Frataxin deficiency promotes endothelial senescence in pulmonary hypertension. J Clin Invest. 2021 06 01; 131(11). Culley MK, Zhao J, Tai YY, Tang Y, Perk D, Negi V, Yu Q, Woodcock CC, Handen A, Speyer G, Kim S, Lai YC, Satoh T, Watson AM, Aaraj YA, Sembrat J, Rojas M, Goncharov D, Goncharova EA, Khan OF, Anderson DG, Dahlman JE, Gurkar AU, Lafyatis R, Fayyaz AU, Redfield MM, Gladwin MT, Rabinovitch M, Gu M, Bertero T, Chan SY. PMID: 33905372; PMCID: PMC8159699.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    32. Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension. Proc Natl Acad Sci U S A. 2021 04 27; 118(17). Daneva Z, Marziano C, Ottolini M, Chen YL, Baker TM, Kuppusamy M, Zhang A, Ta HQ, Reagan CE, Mihalek AD, Kasetti RB, Shen Y, Isakson BE, Minshall RD, Zode GS, Goncharova EA, Laubach VE, Sonkusare SK. PMID: 33879616; PMCID: PMC8092599.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    33. Functional NMDA receptors are expressed by human pulmonary artery smooth muscle cells. Sci Rep. 2021 04 15; 11(1):8205. Dong YN, Hsu FC, Koziol-White CJ, Stepanova V, Jude J, Gritsiuta A, Rue R, Mott R, Coulter DA, Panettieri RA, Krymskaya VP, Takano H, Goncharova EA, Goncharov DA, Cines DB, Lynch DR. PMID: 33859248; PMCID: PMC8050278.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    34. Update in Pulmonary Vascular Diseases and Right Ventricular Dysfunction 2019. Am J Respir Crit Care Med. 2020 07 01; 202(1):22-28. Goncharova EA, Chan SY, Ventetuolo CE, Weissmann N, Schermuly RT, Mullin CJ, Gladwin MT. PMID: 32311291; PMCID: PMC7328315.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    35. mTORC1 in Pulmonary Arterial Hypertension. At the Crossroads between Vasoconstriction and Vascular Remodeling? Am J Respir Crit Care Med. 2020 05 15; 201(10):1177-1179. Goncharova EA, Simon MA, Yuan JX. PMID: 31968178; PMCID: PMC7233339.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    36. Treatment With Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. Arterioscler Thromb Vasc Biol. 2020 06; 40(6):1543-1558. Wang L, Halliday G, Huot JR, Satoh T, Baust JJ, Fisher A, Cook T, Hu J, Avolio T, Goncharov DA, Bai Y, Vanderpool RR, Considine RV, Bonetto A, Tan J, Bachman TN, Sebastiani A, McTiernan CF, Mora AL, Machado RF, Goncharova EA, Gladwin MT, Lai YC. PMID: 32268788; PMCID: PMC7255946.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    37. Differential effects of integrin-linked kinase inhibitor Cpd22 on severe pulmonary hypertension in male and female rats. Pulm Circ. 2020 Jan-Mar; 10(1):2045894019898593. Shen Y, Goncharov DA, Avolio T, Ray A, Okorie E, DeLisser H, Mora AL, Vanderpool R, Kudryashova TV, Goncharova EA. PMID: 32110386; PMCID: PMC7016388.
      View in: PubMed   Mentions: 3  
    38. Clonally selected primitive endothelial cells promote occlusive pulmonary arteriopathy and severe pulmonary hypertension in rats exposed to chronic hypoxia. Sci Rep. 2020 01 24; 10(1):1136. Bhagwani AR, Farkas D, Harmon B, Authelet KJ, Cool CD, Kolb M, Goncharova E, Yoder MC, Clauss M, Freishtat R, Farkas L. PMID: 31980720; PMCID: PMC6981224.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    39. Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure. Pulm Circ. 2019 Oct-Dec; 9(4):2045894019889775. Spiekerkoetter E, Goncharova EA, Guignabert C, Stenmark K, Kwapiszewska G, Rabinovitch M, Voelkel N, Bogaard HJ, Graham B, Pullamsetti SS, Kuebler WM. PMID: 31798835; PMCID: PMC6868582.
      View in: PubMed   Mentions: 18  
    40. Distinct plasma gradients of microRNA-204 in the pulmonary circulation of patients suffering from WHO Groups I and II pulmonary hypertension. Pulm Circ. 2019 Apr-Jun; 9(2):2045894019840646. Estephan LE, Genuardi MV, Kosanovich CM, Risbano MG, Zhang Y, Petro N, Watson A, Al Aaraj Y, Sembrat JC, Rojas M, Goncharov DA, Simon MA, Goncharova EA, Vaidya A, Smith A, Mazurek J, Han Y, Chan SY. PMID: 30854934; PMCID: PMC6440051.
      View in: PubMed   Mentions: 10  
    41. Toll-like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension. Am J Respir Crit Care Med. 2019 01 15; 199(2):199-210. Farkas D, Thompson AAR, Bhagwani AR, Hultman S, Ji H, Kotha N, Farr G, Arnold ND, Braithwaite A, Casbolt H, Cole JE, Sabroe I, Monaco C, Cool CD, Goncharova EA, Lawrie A, Farkas L. PMID: 30211629; PMCID: PMC6353001.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    42. TAKling GDF-15 and skeletal muscle atrophy in pulmonary hypertension: are we there yet? Thorax. 2019 02; 74(2):103-105. Lai YC, Provencher S, Goncharova EA. PMID: 30554140.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    43. Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension. Int J Mol Sci. 2018 Sep 28; 19(10). Kudryashova TV, Shen Y, Pena A, Cronin E, Okorie E, Goncharov DA, Goncharova EA. PMID: 30274147; PMCID: PMC6212879.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    44. Metformin Therapy for Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction versus Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2018 09 01; 198(5):681-684. Goncharov DA, Goncharova EA, Tofovic SP, Hu J, Baust JJ, Pena AZ, Ray A, Rode A, Vanderpool RR, Mora AL, Gladwin MT, Lai YC. PMID: 29727194; PMCID: PMC6118018.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    45. TWISTed HIF: revisiting smooth muscle HIF-1α signaling in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2018 09 01; 315(3):L387-L389. Shen YS, Goncharova EA. PMID: 29975104; PMCID: PMC6172622.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    46. Targeting Pulmonary Endothelial Hemoglobin α Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction. Am J Respir Cell Mol Biol. 2017 12; 57(6):733-744. Alvarez RA, Miller MP, Hahn SA, Galley JC, Bauer E, Bachman T, Hu J, Sembrat J, Goncharov D, Mora AL, Rojas M, Goncharova E, Straub AC. PMID: 28800253; PMCID: PMC5765416.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    47. Pharmacological Inhibition of mTOR Kinase Reverses Right Ventricle Remodeling and Improves Right Ventricle Structure and Function in Rats. Am J Respir Cell Mol Biol. 2017 11; 57(5):615-625. Pena A, Kobir A, Goncharov D, Goda A, Kudryashova TV, Ray A, Vanderpool R, Baust J, Chang B, Mora AL, Gorcsan J, Goncharova EA. PMID: 28679058; PMCID: PMC5705904.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    48. Single-Step qPCR and dPCR Detection of Diverse CRISPR-Cas9 Gene Editing Events In Vivo. G3 (Bethesda). 2017 10 05; 7(10):3533-3542. Falabella M, Sun L, Barr J, Pena AZ, Kershaw EE, Gingras S, Goncharova EA, Kaufman BA. PMID: 28860183; PMCID: PMC5633400.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    49. Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation. Clin Sci (Lond). 2017 Aug 01; 131(15):2019-2035. Ghouleh IA, Sahoo S, Meijles DN, Amaral JH, de Jesus DS, Sembrat J, Rojas M, Goncharov DA, Goncharova EA, Pagano PJ. PMID: 28522681; PMCID: PMC5705051.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    50. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension. Sci Rep. 2017 07 03; 7(1):4546. Boucherat O, Chabot S, Paulin R, Trinh I, Bourgeois A, Potus F, Lampron MC, Lambert C, Breuils-Bonnet S, Nadeau V, Paradis R, Goncharova EA, Provencher S, Bonnet S. PMID: 28674407; PMCID: PMC5495763.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    51. Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension, and Heart Failure with Preserved Ejection Fraction. Am J Respir Cell Mol Biol. 2017 04; 56(4):497-505. Meng Q, Lai YC, Kelly NJ, Bueno M, Baust JJ, Bachman TN, Goncharov D, Vanderpool RR, Radder JE, Hu J, Goncharova E, Morris AM, Mora AL, Shapiro SD, Gladwin MT. PMID: 28118022; PMCID: PMC5449511.
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    52. Translational Advances in the Field of Pulmonary Hypertension. From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs. Am J Respir Crit Care Med. 2017 Feb 15; 195(4):425-437. Pullamsetti SS, Savai R, Seeger W, Goncharova EA. PMID: 27627135; PMCID: PMC5803657.
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    53. Automated Measurement of Blood Vessels in Tissues from Microscopy Images. Curr Protoc Cytom. 2016 10 10; 78:12.44.1-12.44.13. Kelly NJ, Dandachi N, Goncharov DA, Pena AZ, Radder JE, Gregory AD, Lai YC, Leme AS, Gladwin MT, Goncharova EA, St Croix CM, Shapiro SD. PMID: 27723088; PMCID: PMC6431235.
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    54. HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 Oct 01; 194(7):866-877. Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HH, Shapiro S, Zhao Y, Goncharova EA. PMID: 27119551; PMCID: PMC5074651.
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    55. mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts. Aging Cell. 2016 Dec; 15(6):1103-1112. Romero Y, Bueno M, Ramirez R, Álvarez D, Sembrat JC, Goncharova EA, Rojas M, Selman M, Mora AL, Pardo A. PMID: 27566137; PMCID: PMC6398527.
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    56. MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension. PLoS One. 2016; 11(5):e0153780. Sahoo S, Meijles DN, Al Ghouleh I, Tandon M, Cifuentes-Pagano E, Sembrat J, Rojas M, Goncharova E, Pagano PJ. PMID: 27144530; PMCID: PMC4856285.
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    57. SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. Circulation. 2016 Feb 23; 133(8):717-31. Lai YC, Tabima DM, Dube JJ, Hughan KS, Vanderpool RR, Goncharov DA, St Croix CM, Garcia-Ocaña A, Goncharova EA, Tofovic SP, Mora AL, Gladwin MT. PMID: 26813102; PMCID: PMC4766041.
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    58. Profiling the role of mammalian target of rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension. Pulm Circ. 2015 Dec; 5(4):667-80. Kudryashova TV, Goncharov DA, Pena A, Ihida-Stansbury K, DeLisser H, Kawut SM, Goncharova EA. PMID: 26697174; PMCID: PMC4671741.
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    59. VCAM-1 is a TGF-β1 inducible gene upregulated in idiopathic pulmonary fibrosis. Cell Signal. 2015 Dec; 27(12):2467-73. Agassandian M, Tedrow JR, Sembrat J, Kass DJ, Zhang Y, Goncharova EA, Kaminski N, Mallampalli RK, Vuga LJ. PMID: 26386411; PMCID: PMC4684430.
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    60. Update in Pulmonary Vascular Diseases 2014. Am J Respir Crit Care Med. 2015 Sep 01; 192(5):544-50. Goncharova EA, Gladwin MT, Kawut SM. PMID: 26561677; PMCID: PMC4595695.
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    61. Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts. PLoS One. 2014; 9(10):e111476. Goncharova EA, James ML, Kudryashova TV, Goncharov DA, Krymskaya VP. PMID: 25360538; PMCID: PMC4216017.
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    62. Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK. Cell Rep. 2014 Apr 24; 7(2):412-423. Goncharova EA, Goncharov DA, James ML, Atochina-Vasserman EN, Stepanova V, Hong SB, Li H, Gonzales L, Baba M, Linehan WM, Gow AJ, Margulies S, Guttentag S, Schmidt LS, Krymskaya VP. PMID: 24726356; PMCID: PMC4034569.
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    63. Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension. Circulation. 2014 Feb 25; 129(8):864-74. Goncharov DA, Kudryashova TV, Ziai H, Ihida-Stansbury K, DeLisser H, Krymskaya VP, Tuder RM, Kawut SM, Goncharova EA. PMID: 24270265; PMCID: PMC3968690.
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    64. mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects. FASEB J. 2013 May; 27(5):1796-807. Goncharova EA. PMID: 23355268; PMCID: PMC3633815.
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    65. Differential effects of formoterol on thrombin- and PDGF-induced proliferation of human pulmonary arterial vascular smooth muscle cells. Respir Res. 2012 Nov 27; 13:109. Goncharova EA, Khavin IS, Goncharov DA, Krymskaya VP. PMID: 23186269; PMCID: PMC3545871.
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    66. Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion. PLoS One. 2012; 7(11):e47842. Medvetz DA, Khabibullin D, Hariharan V, Ongusaha PP, Goncharova EA, Schlechter T, Darling TN, Hofmann I, Krymskaya VP, Liao JK, Huang H, Henske EP. PMID: 23139756; PMCID: PMC3490959.
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    67. Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphangioleiomyomatosis (LAM). Sci Transl Med. 2012 Oct 03; 4(154):154ra134. Goncharova EA, Goncharov DA, Fehrenbach M, Khavin I, Ducka B, Hino O, Colby TV, Merrilees MJ, Haczku A, Albelda SM, Krymskaya VP. PMID: 23035046; PMCID: PMC3684391.
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    68. DHEA-S inhibits human neutrophil and human airway smooth muscle migration. Biochim Biophys Acta. 2012 Oct; 1822(10):1638-42. Koziol-White CJ, Goncharova EA, Cao G, Johnson M, Krymskaya VP, Panettieri RA. PMID: 22771498; PMCID: PMC3418395.
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    69. β2-adrenergic receptor agonists modulate human airway smooth muscle cell migration via vasodilator-stimulated phosphoprotein. Am J Respir Cell Mol Biol. 2012 Jan; 46(1):48-54. Goncharova EA, Goncharov DA, Zhao H, Penn RB, Krymskaya VP, Panettieri RA. PMID: 22210825; PMCID: PMC3262659.
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    70. mTORC2 is required for proliferation and survival of TSC2-null cells. Mol Cell Biol. 2011 Jun; 31(12):2484-98. Goncharova EA, Goncharov DA, Li H, Pimtong W, Lu S, Khavin I, Krymskaya VP. PMID: 21482669; PMCID: PMC3133430.
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    71. mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia. FASEB J. 2011 Jun; 25(6):1922-33. Krymskaya VP, Snow J, Cesarone G, Khavin I, Goncharov DA, Lim PN, Veasey SC, Ihida-Stansbury K, Jones PL, Goncharova EA. PMID: 21368105; PMCID: PMC3101038.
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    72. Interferons modulate mitogen-induced protein synthesis in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L25-35. Goncharova EA, Lim PN, Chisolm A, Fogle HW, Taylor JH, Goncharov DA, Eszterhas A, Panettieri RA, Krymskaya VP. PMID: 20382746; PMCID: PMC2904093.
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    73. Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1. Br J Pharmacol. 2009 Nov; 158(6):1429-41. Damera G, Fogle HW, Lim P, Goncharova EA, Zhao H, Banerjee A, Tliba O, Krymskaya VP, Panettieri RA. PMID: 19814732; PMCID: PMC2795210.
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    74. Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis. Mol Pharmacol. 2009 Oct; 76(4):766-77. Goncharova EA, Goncharov DA, Damera G, Tliba O, Amrani Y, Panettieri RA, Krymskaya VP. PMID: 19596836; PMCID: PMC2769052.
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    75. PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects. Cell Cycle. 2009 Feb 01; 8(3):403-13. Krymskaya VP, Goncharova EA. PMID: 19177005; PMCID: PMC3718392.
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    76. Pulmonary lymphangioleiomyomatosis (LAM): progress and current challenges. J Cell Biochem. 2008 Feb 01; 103(2):369-82. Goncharova EA, Krymskaya VP. PMID: 17541983.
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    77. Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation. Mol Pharmacol. 2008 Mar; 73(3):778-88. Goncharova EA, Goncharov DA, Chisolm A, Spaits MS, Lim PN, Cesarone G, Khavin I, Tliba O, Amrani Y, Panettieri RA, Krymskaya VP. PMID: 18094073.
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    78. Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2. Am J Respir Cell Mol Biol. 2006 May; 34(5):561-72. Goncharova EA, Goncharov DA, Spaits M, Noonan DJ, Talovskaya E, Eszterhas A, Krymskaya VP. PMID: 16424383; PMCID: PMC2644221.
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    79. Assays for in vitro monitoring of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cell migration. Nat Protoc. 2006; 1(6):2933-9. Goncharova EA, Goncharov DA, Krymskaya VP. PMID: 17406553.
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    80. Assays for in vitro monitoring of proliferation of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cells. Nat Protoc. 2006; 1(6):2905-8. Goncharova EA, Lim P, Goncharov DA, Eszterhas A, Panettieri RA, Krymskaya VP. PMID: 17406550.
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    81. Modulation of cell migration and invasiveness by tumor suppressor TSC2 in lymphangioleiomyomatosis. Am J Respir Cell Mol Biol. 2006 Apr; 34(4):473-80. Goncharova EA, Goncharov DA, Lim PN, Noonan D, Krymskaya VP. PMID: 16388022; PMCID: PMC2644208.
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    82. Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration. FASEB J. 2005 Mar; 19(3):428-30. Krymskaya VP, Goncharova EA, Ammit AJ, Lim PN, Goncharov DA, Eszterhas A, Panettieri RA. PMID: 15746183.
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    83. TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. J Cell Biol. 2004 Dec 20; 167(6):1171-82. Goncharova E, Goncharov D, Noonan D, Krymskaya VP. PMID: 15611338; PMCID: PMC2172598.
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    84. Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent. Am J Physiol Lung Cell Mol Physiol. 2004 Mar; 286(3):L539-45. Kazi AS, Lotfi S, Goncharova EA, Tliba O, Amrani Y, Krymskaya VP, Lazaar AL. PMID: 14633511.
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    85. Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):19-27. Goncharova EA, Billington CK, Irani C, Vorotnikov AV, Tkachuk VA, Penn RB, Krymskaya VP, Panettieri RA. PMID: 12600820.
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    86. PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2002 Aug; 283(2):L354-63. Goncharova EA, Ammit AJ, Irani C, Carroll RG, Eszterhas AJ, Panettieri RA, Krymskaya VP. PMID: 12114197.
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    87. Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J Biol Chem. 2002 Aug 23; 277(34):30958-67. Goncharova EA, Goncharov DA, Eszterhas A, Hunter DS, Glassberg MK, Yeung RS, Walker CL, Noonan D, Kwiatkowski DJ, Chou MM, Panettieri RA, Krymskaya VP. PMID: 12045200.
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    88. Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L854-62. Irani C, Goncharova EA, Hunter DS, Walker CL, Panettieri RA, Krymskaya VP. PMID: 11880313.
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    89. Activation of p38 MAP-kinase and caldesmon phosphorylation are essential for urokinase-induced human smooth muscle cell migration. Biol Chem. 2002 Jan; 383(1):115-26. Goncharova EA, Vorotnikov AV, Gracheva EO, Wang CL, Panettieri RA, Stepanova VV, Tkachuk VA. PMID: 11930938.
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    90. Actomyosin cross-linking by caldesmon in non-muscle cells. FEBS Lett. 2001 May 25; 497(2-3):113-7. Goncharova EA, Shirinsky VP, Shevelev AY, Marston SB, Vorotnikov AV. PMID: 11377424.
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    91. [The role of mitogen-activated protein kinases in stimulation of the smooth muscle cell migration by urokinase]. Zh Evol Biokhim Fiziol. 2000 Nov-Dec; 36(6):569-75. Goncharova EA, Tkachuk VA, Ratner EI, Parfenova EV, Vorotnikov AV. PMID: 11212536.
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    92. [The role of "growth" domain of urokinase in migration of smooth muscle cells]. Ross Fiziol Zh Im I M Sechenova. 1997 Nov-Dec; 83(11-12):158-67. Stepanova VV, Goncharova EA, Bibilashvili RSh, Tkachuk VA. PMID: 9541968.
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    93. Urokinase plasminogen activator induces smooth muscle cell migration: key role of growth factor-like domain. FEBS Lett. 1997 Sep 08; 414(2):471-4. Stepanova V, Bobik A, Bibilashvily R, Belogurov A, Rybalkin I, Domogatsky S, Little PJ, Goncharova E, Tkachuk V. PMID: 9315743.
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