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Laura Van Winkle

TitlePROF-SFT-VM
InstitutionUniversity of California Davis
DepartmentCNTR FOR HEALTH & ENVIRONMENT
Address508 CHE
CA 95616
Phone530-754-7547
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Van Winkle L, Kelty JS, Plopper CG. Preparation of Specific Compartments of the Lungs for Pathologic and Biochemical Analysis of Toxicologic Responses. Curr Protoc Toxicol. 2017 Feb 01; 71:24.5.1-24.5.26. PMID: 28146282.
      View in: PubMed
    2. Das GK, Anderson DS, Wallis CD, Carratt SA, Kennedy IM, Van Winkle L. Novel multi-functional europium-doped gadolinium oxide nanoparticle aerosols facilitate the study of deposition in the developing rat lung. Nanoscale. 2016 Jun 02; 8(22):11518-30. PMID: 27198643; PMCID: PMC5025943 [Available on 06/02/17].
    3. Patchin ES, Anderson DS, Silva RM, Uyeminami DL, Scott GM, Guo T, Van Winkle L, Pinkerton KE. Size-Dependent Deposition, Translocation, and Microglial Activation of Inhaled Silver Nanoparticles in the Rodent Nose and Brain. Environ Health Perspect. 2016 12; 124(12):1870-1875. PMID: 27152509.
      View in: PubMed
    4. Silva RM, Anderson DS, Peake J, Edwards PC, Patchin ES, Guo T, Gordon T, Chen LC, Sun X, Van Winkle L, Pinkerton KE. Aerosolized Silver Nanoparticles in the Rat Lung and Pulmonary Responses over Time. Toxicol Pathol. 2016 07; 44(5):673-86. PMID: 27025955; PMCID: PMC4912458 [Available on 07/01/17].
    5. Liu YX, Karsai A, Anderson DS, Silva RM, Uyeminami DL, Van Winkle L, Pinkerton KE, Liu GY. Single-Cell Mechanics Provides an Effective Means To Probe in Vivo Interactions between Alveolar Macrophages and Silver Nanoparticles. J Phys Chem B. 2015 Dec 10; 119(49):15118-29. PMID: 26562364.
      View in: PubMed
    6. Pinkerton KE, Harbaugh M, Han MK, Jourdan Le Saux C, Van Winkle L, Martin WJ, Kosgei RJ, Carter EJ, Sitkin N, Smiley-Jewell SM, George M. Women and Lung Disease. Sex Differences and Global Health Disparities. Am J Respir Crit Care Med. 2015 Jul 01; 192(1):11-6. PMID: 25945507; PMCID: PMC4511423.
    7. K├╝ltz D, Li J, Sacchi R, Morin D, Buckpitt A, Van Winkle L. Alterations in the proteome of the respiratory tract in response to single and multiple exposures to naphthalene. Proteomics. 2015 Aug; 15(15):2655-68. PMID: 25825134; PMCID: PMC4772669.
    8. Silva RM, Anderson DS, Franzi LM, Peake JL, Edwards PC, Van Winkle L, Pinkerton KE. Pulmonary effects of silver nanoparticle size, coating, and dose over time upon intratracheal instillation. Toxicol Sci. 2015 Mar; 144(1):151-62. PMID: 25628415; PMCID: PMC4349140.
    9. Anderson DS, Patchin ES, Silva RM, Uyeminami DL, Sharmah A, Guo T, Das GK, Brown JM, Shannahan J, Gordon T, Chen LC, Pinkerton KE, Van Winkle L. Influence of particle size on persistence and clearance of aerosolized silver nanoparticles in the rat lung. Toxicol Sci. 2015 Apr; 144(2):366-81. PMID: 25577195; PMCID: PMC4372666.
    10. Davidson RA, Anderson DS, Van Winkle L, Pinkerton KE, Guo T. Evolution of silver nanoparticles in the rat lung investigated by X-ray absorption spectroscopy. J Phys Chem A. 2015 Jan 15; 119(2):281-9. PMID: 25517690.
      View in: PubMed
    11. Van Winkle L, Bein K, Anderson D, Pinkerton KE, Tablin F, Wilson D, Wexler AS. Biological dose response to PM2.5: effect of particle extraction method on platelet and lung responses. Toxicol Sci. 2015 Feb; 143(2):349-59. PMID: 25389146; PMCID: PMC4306718.
    12. Silva RM, Xu J, Saiki C, Anderson DS, Franzi LM, Vulpe CD, Gilbert B, Van Winkle L, Pinkerton KE. Short versus long silver nanowires: a comparison of in vivo pulmonary effects post instillation. Part Fibre Toxicol. 2014 Oct 08; 11:52. PMID: 25292367; PMCID: PMC4198797.
    13. Anderson DS, Silva RM, Lee D, Edwards PC, Sharmah A, Guo T, Pinkerton KE, Van Winkle L. Persistence of silver nanoparticles in the rat lung: Influence of dose, size, and chemical composition. Nanotoxicology. 2015; 9(5):591-602. PMID: 25231189; PMCID: PMC4364933.
    14. Silva RM, Doudrick K, Franzi LM, TeeSy C, Anderson DS, Wu Z, Mitra S, Vu V, Dutrow G, Evans JE, Westerhoff P, Van Winkle L, Raabe OG, Pinkerton KE. Instillation versus inhalation of multiwalled carbon nanotubes: exposure-related health effects, clearance, and the role of particle characteristics. ACS Nano. 2014 Sep 23; 8(9):8911-31. PMID: 25144856; PMCID: PMC4174094.
    15. Murphy SR, Oslund KL, Hyde DM, Miller LA, Van Winkle L, Schelegle ES. Ozone-induced airway epithelial cell death, the neurokinin-1 receptor pathway, and the postnatal developing lung. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L471-81. PMID: 25063800; PMCID: PMC4166783.
    16. Cichocki JA, Smith GJ, Mendoza R, Buckpitt AR, Van Winkle L, Morris JB. Sex differences in the acute nasal antioxidant/antielectrophilic response of the rat to inhaled naphthalene. Toxicol Sci. 2014 May; 139(1):234-44. PMID: 24563378.
      View in: PubMed
    17. Chan JK, Charrier JG, Kodani SD, Vogel CF, Kado SY, Anderson DS, Anastasio C, Van Winkle L. Combustion-derived flame generated ultrafine soot generates reactive oxygen species and activates Nrf2 antioxidants differently in neonatal and adult rat lungs. Part Fibre Toxicol. 2013 Aug 01; 10:34. PMID: 23902943; PMCID: PMC3735485.
    18. Van Winkle L, Murphy SR, Boetticher MV, VandeVoort CA. Fetal exposure of rhesus macaques to bisphenol a alters cellular development of the conducting airway by changing epithelial secretory product expression. Environ Health Perspect. 2013 Aug; 121(8):912-8. PMID: 23757601; PMCID: PMC3734491.
    19. Buckpitt A, Morin D, Murphy S, Edwards P, Van Winkle L. Kinetics of naphthalene metabolism in target and non-target tissues of rodents and in nasal and airway microsomes from the Rhesus monkey. Toxicol Appl Pharmacol. 2013 Jul 15; 270(2):97-105. PMID: 23602890.
      View in: PubMed
    20. Murphy SR, Schelegle ES, Miller LA, Hyde DM, Van Winkle L. Ozone exposure alters serotonin and serotonin receptor expression in the developing lung. Toxicol Sci. 2013 Jul; 134(1):168-79. PMID: 23570994; PMCID: PMC3693130.
    21. Chan JK, Vogel CF, Baek J, Kodani SD, Uppal RS, Bein KJ, Anderson DS, Van Winkle L. Combustion derived ultrafine particles induce cytochrome P-450 expression in specific lung compartments in the developing neonatal and adult rat. Am J Physiol Lung Cell Mol Physiol. 2013 May 15; 304(10):L665-77. PMID: 23502512; PMCID: PMC3652057.
    22. Abid AD, Anderson DS, Das GK, Van Winkle L, Kennedy IM. Novel lanthanide-labeled metal oxide nanoparticles improve the measurement of in vivo clearance and translocation. Part Fibre Toxicol. 2013 Jan 10; 10:1. PMID: 23305071; PMCID: PMC3560106.
    23. Gharib SA, Altemeier WA, Van Winkle L, Plopper CG, Schlesinger SY, Buell CA, Brauer R, Lee V, Parks WC, Chen P. Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells. Am J Respir Cell Mol Biol. 2013 Mar; 48(3):390-6. PMID: 23258229; PMCID: PMC3604090.
    24. Chan JK, Kodani SD, Charrier JG, Morin D, Edwards PC, Anderson DS, Anastasio C, Van Winkle L. Age-specific effects on rat lung glutathione and antioxidant enzymes after inhaling ultrafine soot. Am J Respir Cell Mol Biol. 2013 Jan; 48(1):114-24. PMID: 23065132; PMCID: PMC3547088.
    25. Murphy SR, Schelegle ES, Edwards PC, Miller LA, Hyde DM, Van Winkle L. Postnatal exposure history and airways: oxidant stress responses in airway explants. Am J Respir Cell Mol Biol. 2012 Dec; 47(6):815-23. PMID: 22962062; PMCID: PMC3547096.
    26. Mitchell VL, Van Winkle L, Gershwin LJ. Environmental tobacco smoke and progesterone alter lung inflammation and mucous metaplasia in a mouse model of allergic airway disease. Clin Rev Allergy Immunol. 2012 Aug; 43(1-2):57-68. PMID: 21837398.
      View in: PubMed
    27. Chan JK, Fanucchi MV, Anderson DS, Abid AD, Wallis CD, Dickinson DA, Kumfer BM, Kennedy IM, Wexler AS, Van Winkle L. Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs. Toxicol Sci. 2011 Dec; 124(2):472-86. PMID: 21914721; PMCID: PMC3216412.
    28. Lee D, Wallis C, Van Winkle L, Wexler AS. Disruption of tracheobronchial airway growth following postnatal exposure to ozone and ultrafine particles. Inhal Toxicol. 2011 Aug; 23(9):520-31. PMID: 21780864.
      View in: PubMed
    29. Li L, Wei Y, Van Winkle L, Zhang QY, Zhou X, Hu J, Xie F, Kluetzman K, Ding X. Generation and characterization of a Cyp2f2-null mouse and studies on the role of CYP2F2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa. J Pharmacol Exp Ther. 2011 Oct; 339(1):62-71. PMID: 21730012; PMCID: PMC3186285.
    30. Wu D, Nishimura N, Kuo V, Fiehn O, Shahbaz S, Van Winkle L, Matsumura F, Vogel CF. Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherosclerosis in apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol. 2011 Jun; 31(6):1260-7. PMID: 21441140; PMCID: PMC3098318.
    31. Van Winkle L, Chan JK, Anderson DS, Kumfer BM, Kennedy IM, Wexler AS, Wallis C, Abid AD, Sutherland KM, Fanucchi MV. Age specific responses to acute inhalation of diffusion flame soot particles: cellular injury and the airway antioxidant response. Inhal Toxicol. 2010 Dec; 22 Suppl 2:70-83. PMID: 20961279; PMCID: PMC3111018.
    32. Sutherland KM, Combs TJ, Edwards PC, Van Winkle L. Site-specific differences in gene expression of secreted proteins in the mouse lung: comparison of methods to show differences by location. J Histochem Cytochem. 2010 Dec; 58(12):1107-19. PMID: 20852037; PMCID: PMC2989247.
    33. Lee D, Wallis C, Wexler AS, Schelegle ES, Van Winkle L, Plopper CG, Fanucchi MV, Kumfer B, Kennedy IM, Chan JK. Small particles disrupt postnatal airway development. J Appl Physiol (1985). 2010 Oct; 109(4):1115-24. PMID: 20634362; PMCID: PMC4182294.
    34. Van Winkle L, Baker GL, Chan JK, Schelegle ES, Plopper CG. Airway mast cells in a rhesus model of childhood allergic airways disease. Toxicol Sci. 2010 Jul; 116(1):313-22. PMID: 20403968; PMCID: PMC2886865.
    35. Dey R, Van Winkle L, Ewart G, Balmes J, Pinkerton K. A second chance. Setting a protective ozone standard. Am J Respir Crit Care Med. 2010 Feb 15; 181(4):297-9. PMID: 20130144.
      View in: PubMed
    36. Coppens JT, Plopper CG, Murphy SR, Van Winkle L. Postnatal lung development of rhesus monkey airways: cellular expression of Clara cell secretory protein. Dev Dyn. 2009 Dec; 238(12):3016-24. PMID: 19877270.
      View in: PubMed
    37. Greeley MA, Van Winkle L, Edwards PC, Plopper CG. Airway trefoil factor expression during naphthalene injury and repair. Toxicol Sci. 2010 Feb; 113(2):453-67. PMID: 19880587; PMCID: PMC2807036.
    38. Coppens JT, Van Winkle L, Pinkerton K, Plopper CG. Distribution of Clara cell secretory protein expression in the tracheobronchial airways of rhesus monkeys. Am J Physiol Lung Cell Mol Physiol. 2007 May; 292(5):L1155-62. PMID: 17237148.
      View in: PubMed
    39. Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic M, Gershwin LJ, Joad JP, Kajekar R, Larson S, Pinkerton KE, Van Winkle L, Schelegle ES, Pieczarka EM, Wu R, Hyde DM. Asthma/allergic airways disease: does postnatal exposure to environmental toxicants promote airway pathobiology? Toxicol Pathol. 2007 Jan; 35(1):97-110. PMID: 17325978.
      View in: PubMed
    40. Fanucchi MV, Plopper CG, Evans MJ, Hyde DM, Van Winkle L, Gershwin LJ, Schelegle ES. Cyclic exposure to ozone alters distal airway development in infant rhesus monkeys. Am J Physiol Lung Cell Mol Physiol. 2006 Oct; 291(4):L644-50. PMID: 16648242.
      View in: PubMed
    41. Stelck RL, Baker GL, Sutherland KM, Van Winkle L. Estrous cycle alters naphthalene metabolism in female mouse airways. Drug Metab Dispos. 2005 Nov; 33(11):1597-602. PMID: 16085760.
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    42. Phimister AJ, Williams KJ, Van Winkle L, Plopper CG. Consequences of abrupt glutathione depletion in murine Clara cells: ultrastructural and biochemical investigations into the role of glutathione loss in naphthalene cytotoxicity. J Pharmacol Exp Ther. 2005 Aug; 314(2):506-13. PMID: 15845860.
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    43. Van Winkle L, Brown CD, Shimizu JA, Gunderson AD, Evans MJ, Plopper CG. Impaired recovery from naphthalene-induced bronchiolar epithelial injury in mice exposed to aged and diluted sidestream cigarette smoke. Toxicol Lett. 2004 Dec 01; 154(1-2):1-9. PMID: 15475173.
      View in: PubMed
    44. Tran MU, Weir AJ, Fanucchi MV, Murphy AE, Van Winkle L, Evans MJ, Smiley-Jewell SM, Miller L, Schelegle ES, Gershwin LJ, Hyde DM, Plopper CG. Smooth muscle development during postnatal growth of distal bronchioles in infant rhesus monkeys. J Appl Physiol (1985). 2004 Dec; 97(6):2364-71; discussion 2354. PMID: 15347627.
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    45. Van Winkle L, Fanucchi MV, Miller LA, Baker GL, Gershwin LJ, Schelegle ES, Hyde DM, Evans MJ, Plopper CG. Epithelial cell distribution and abundance in rhesus monkey airways during postnatal lung growth and development. J Appl Physiol (1985). 2004 Dec; 97(6):2355-63; discussion 2354. PMID: 15298983.
      View in: PubMed
    46. Schelegle ES, Miller LA, Gershwin LJ, Fanucchi MV, Van Winkle L, Gerriets JE, Walby WF, Mitchell V, Tarkington BK, Wong VJ, Baker GL, Pantle LM, Joad JP, Pinkerton KE, Wu R, Evans MJ, Hyde DM, Plopper CG. Repeated episodes of ozone inhalation amplifies the effects of allergen sensitization and inhalation on airway immune and structural development in Rhesus monkeys. Toxicol Appl Pharmacol. 2003 Aug 15; 191(1):74-85. PMID: 12915105.
      View in: PubMed
    47. Phimister AJ, Day KC, Gunderson AD, Wong VJ, Lawson GW, Fanucchi MV, Van Winkle L, Kendall LV, Plopper CG. Detection of viral infection in the respiratory tract of virus antibody free mice: advantages of high-resolution imaging for respiratory toxicology. Toxicol Appl Pharmacol. 2003 Aug 01; 190(3):286-93. PMID: 12902200.
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    48. Evans MJ, Fanucchi MV, Baker GL, Van Winkle L, Pantle LM, Nishio SJ, Schelegle ES, Gershwin LJ, Miller LA, Hyde DM, Sannes PL, Plopper CG. Atypical development of the tracheal basement membrane zone of infant rhesus monkeys exposed to ozone and allergen. Am J Physiol Lung Cell Mol Physiol. 2003 Oct; 285(4):L931-9. PMID: 12832283.
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    49. West JA, Van Winkle L, Morin D, Fleschner CA, Forman HJ, Plopper CG. Repeated inhalation exposures to the bioactivated cytotoxicant naphthalene (NA) produce airway-specific Clara cell tolerance in mice. Toxicol Sci. 2003 Sep; 75(1):161-8. PMID: 12805647.
      View in: PubMed
    50. Evans MJ, Van Winkle L, Fanucchi MV, Baker GL, Murphy AE, Nishio SJ, Schelegle ES, Gershwin LJ, Sannes PL, Plopper CG. Fibroblast growth factor-2 in remodeling of the developing basement membrane zone in the trachea of infant rhesus monkeys sensitized and challenged with allergen. Lab Invest. 2002 Dec; 82(12):1747-54. PMID: 12480924.
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    51. Evans MJ, Fanucchi MV, Van Winkle L, Baker GL, Murphy AE, Nishio SJ, Sannes PL, Plopper CG. Fibroblast growth factor-2 during postnatal development of the tracheal basement membrane zone. Am J Physiol Lung Cell Mol Physiol. 2002 Dec; 283(6):L1263-70. PMID: 12388330.
      View in: PubMed
    52. Van Winkle L, Gunderson AD, Shimizu JA, Baker GL, Brown CD. Gender differences in naphthalene metabolism and naphthalene-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2002 May; 282(5):L1122-34. PMID: 11943679.
      View in: PubMed
    53. Lawson GW, Van Winkle L, Toskala E, Senior RM, Parks WC, Plopper CG. Mouse strain modulates the role of the ciliated cell in acute tracheobronchial airway injury-distal airways. Am J Pathol. 2002 Jan; 160(1):315-27. PMID: 11786425; PMCID: PMC1867146.
    54. Van Winkle L, Evans MJ, Brown CD, Willits NH, Pinkerton KE, Plopper CG. Prior exposure to aged and diluted sidestream cigarette smoke impairs bronchiolar injury and repair. Toxicol Sci. 2001 Mar; 60(1):152-64. PMID: 11222882.
      View in: PubMed