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Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science. 2023 Feb 17; 379(6633):700-706.
Vargas MV, Dunlap LE, Dong C, Carter SJ, Tombari RJ, Jami SA, Cameron LP, Patel SD, Hennessey JJ, Saeger HN, McCorvy JD, Gray JA, Tian L, Olson DE. PMID: 36795823.
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1 Fields:
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AnimalsCells
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Developmental Neurotoxicity Screen of Psychedelics and Other Drugs of Abuse in Larval Zebrafish (Danio rerio). ACS Chem Neurosci. 2023 Feb 08.
Tombari RJ, Mundy PC, Morales KM, Dunlap LE, Olson DE, Lein PJ. PMID: 36753397.
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Animals
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5-HT2ARs Mediate Therapeutic Behavioral Effects of Psychedelic Tryptamines. ACS Chem Neurosci. 2023 Feb 01; 14(3):351-358.
Cameron LP, Patel SD, Vargas MV, Barragan EV, Saeger HN, Warren HT, Chow WL, Gray JA, Olson DE. PMID: 36630260.
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HumansAnimals
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Resting state brain dynamics: Associations with childhood sexual abuse and major depressive disorder. Neuroimage Clin. 2022; 36:103164.
Belleau EL, Bolton TAW, Kaiser RH, Clegg R, C?rdenas E, Goer F, Pechtel P, Beltzer M, Vitaliano G, Olson DP, Teicher MH, Pizzagalli DA. PMID: 36044792; PMCID: PMC9449675.
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Humans
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Synthesis of Tertiary Amines through Extrusive Alkylation of Carbamates. Org Lett. 2022 08 26; 24(33):6208-6212.
Zhang G, Favela D, Chow WL, Iyer RN, Pell AJ, Olson DE. PMID: 35972395; PMCID: PMC9420822.
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Cells
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Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity. Biochemistry. 2022 02 01; 61(3):127-136.
Olson DE. PMID: 35060714; PMCID: PMC9004607.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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The evolution of the psychedelic revolution. Neuropsychopharmacology. 2022 01; 47(1):413-414.
Cameron LP, Olson DE. PMID: 34400786; PMCID: PMC8616895.
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3 Fields:
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Sex-Specific Social Effects on Depression-Related Behavioral Phenotypes in Mice. Life (Basel). 2021 Dec 01; 11(12).
Patel SD, Cameron LP, Olson DE. PMID: 34947858; PMCID: PMC8705323.
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Psychedelics and Other Psychoplastogens for Treating Mental Illness. Front Psychiatry. 2021; 12:727117.
Vargas MV, Meyer R, Avanes AA, Rus M, Olson DE. PMID: 34671279; PMCID: PMC8520991.
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PubMed Mentions:
15
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Calculated oxidation potentials predict reactivity in Baeyer-Mills reactions. Org Biomol Chem. 2021 09 15; 19(35):7575-7580.
Tombari RJ, Tuck JR, Yardeny N, Gingrich PW, Tantillo DJ, Olson DE. PMID: 34524347; PMCID: PMC8462971.
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PubMed Mentions:
3 Fields:
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An analog of psychedelics restores functional neural circuits disrupted by unpredictable stress. Mol Psychiatry. 2021 11; 26(11):6237-6252.
Lu J, Tjia M, Mullen B, Cao B, Lukasiewicz K, Shah-Morales S, Weiser S, Cameron LP, Olson DE, Chen L, Zuo Y. PMID: 34035476; PMCID: PMC8613316.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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A Modular Approach to Arylazo-1,2,3-triazole Photoswitches. Org Lett. 2021 06 04; 23(11):4305-4310.
Tuck JR, Tombari RJ, Yardeny N, Olson DE. PMID: 34019429; PMCID: PMC8276588.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Psychedelic-inspired drug discovery using an engineered biosensor. Cell. 2021 05 13; 184(10):2779-2792.e18.
Dong C, Ly C, Dunlap LE, Vargas MV, Sun J, Hwang IW, Azinfar A, Oh WC, Wetsel WC, Olson DE, Tian L. PMID: 33915107; PMCID: PMC8122087.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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The Promise of Psychedelic Science. ACS Pharmacol Transl Sci. 2021 Apr 09; 4(2):413-415.
Olson DE. PMID: 33860170; PMCID: PMC8033768.
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PubMed Mentions:
3
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The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs. Nat Prod Rep. 2021 03 04; 38(2):307-329.
Iyer RN, Favela D, Zhang G, Olson DE. PMID: 32794540; PMCID: PMC7882011.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell. 2020 12 23; 183(7):1986-2002.e26.
Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L. PMID: 33333022; PMCID: PMC8025677.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects. ACS Pharmacol Transl Sci. 2021 Apr 09; 4(2):563-567.
Olson DE. PMID: 33861218; PMCID: PMC8033607.
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PubMed Mentions:
40
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A non-hallucinogenic psychedelic analogue with therapeutic potential. Nature. 2021 01; 589(7842):474-479.
Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia M, Dunlap LE, Rabow ZT, Fiehn O, Wulff H, McCorvy JD, Lein PJ, Kokel D, Ron D, Peters J, Zuo Y, Olson DE. PMID: 33299186; PMCID: PMC7874389.
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PubMed Mentions:
62 Fields:
Translation:
Animals
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Prenatal Androgenization Alters the Development of GnRH Neuron and Preoptic Area RNA Transcripts in Female Mice. Endocrinology. 2020 11 01; 161(11).
Burger LL, Wagenmaker ER, Phumsatitpong C, Olson DP, Moenter SM. PMID: 33095238; PMCID: PMC7583650.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Transient Stimulation with Psychoplastogens Is Sufficient to Initiate Neuronal Growth. ACS Pharmacol Transl Sci. 2021 Apr 09; 4(2):452-460.
Ly C, Greb AC, Vargas MV, Duim WC, Grodzki ACG, Lein PJ, Olson DE. PMID: 33860174; PMCID: PMC8033616.
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PubMed Mentions:
17
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Bryostatin 1 Promotes Synaptogenesis and Reduces Dendritic Spine Density in Cortical Cultures through a PKC-Dependent Mechanism. ACS Chem Neurosci. 2020 06 03; 11(11):1545-1554.
Ly C, Shimizu AJ, Vargas MV, Duim WC, Wender PA, Olson DE. PMID: 32437156; PMCID: PMC7332236.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies. J Med Chem. 2020 02 13; 63(3):1142-1155.
Dunlap LE, Azinfar A, Ly C, Cameron LP, Viswanathan J, Tombari RJ, Myers-Turnbull D, Taylor JC, Grodzki AC, Lein PJ, Kokel D, Olson DE. PMID: 31977208; PMCID: PMC7075704.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Psychedelic Microdosing: Prevalence and Subjective Effects. J Psychoactive Drugs. 2020 Apr-Jun; 52(2):113-122.
Cameron LP, Nazarian A, Olson DE. PMID: 31973684; PMCID: PMC7282936.
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PubMed Mentions:
23 Fields:
Translation:
Humans
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Reconsidering the Structure of Serlyticin-A. J Nat Prod. 2019 12 27; 82(12):3464-3468.
Tsui KY, Tombari RJ, Olson DE, Tantillo DJ. PMID: 31840986; PMCID: PMC7187649.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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A Redox Isomerization Strategy for Accessing Modular Azobenzene Photoswitches with Near Quantitative Bidirectional Photoconversion. Org Lett. 2019 11 01; 21(21):8765-8770.
Zhu JS, Larach JM, Tombari RJ, Gingrich PW, Bode SR, Tuck JR, Warren HT, Son JH, Duim WC, Fettinger JC, Haddadin MJ, Tantillo DJ, Kurth MJ, Olson DE. PMID: 31638403; PMCID: PMC7158698.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Ex Vivo Analysis of Tryptophan Metabolism Using 19F NMR. ACS Chem Biol. 2019 09 20; 14(9):1866-1873.
Tombari RJ, Saunders CM, Wu CY, Dunlap LE, Tantillo DJ, Olson DE. PMID: 31449387; PMCID: PMC7075705.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents. ACS Chem Neurosci. 2019 07 17; 10(7):3261-3270.
Cameron LP, Benson CJ, DeFelice BC, Fiehn O, Olson DE. PMID: 30829033; PMCID: PMC6639775.
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PubMed Mentions:
43 Fields:
Translation:
Animals
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Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS Cent Sci. 2018 Dec 26; 4(12):1727-1741.
Kearney SE, Zahoránszky-Kohalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM. PMID: 30648156; PMCID: PMC6311695.
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PubMed Mentions:
18
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Psychoplastogens: A Promising Class of Plasticity-Promoting Neurotherapeutics. J Exp Neurosci. 2018; 12:1179069518800508.
Olson DE. PMID: 30262987; PMCID: PMC6149016.
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PubMed Mentions:
47
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Dark Classics in Chemical Neuroscience: N, N-Dimethyltryptamine (DMT). ACS Chem Neurosci. 2018 10 17; 9(10):2344-2357.
Cameron LP, Olson DE. PMID: 30036036.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimals
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Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine. ACS Chem Neurosci. 2018 10 17; 9(10):2408-2427.
Dunlap LE, Andrews AM, Olson DE. PMID: 30001118; PMCID: PMC6197894.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Psychedelics Promote Structural and Functional Neural Plasticity. Cell Rep. 2018 06 12; 23(11):3170-3182.
Ly C, Greb AC, Cameron LP, Wong JM, Barragan EV, Wilson PC, Burbach KF, Soltanzadeh Zarandi S, Sood A, Paddy MR, Duim WC, Dennis MY, McAllister AK, Ori-McKenney KM, Gray JA, Olson DE. PMID: 29898390; PMCID: PMC6082376.
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PubMed Mentions:
201 Fields:
Translation:
AnimalsCells
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Reaction of N,N-Dimethyltryptamine with Dichloromethane Under Common Experimental Conditions. ACS Omega. 2018 May 31; 3(5):4968-4973.
Dunlap LE, Olson DE. PMID: 29876537; PMCID: PMC5981293.
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PubMed Mentions:
3
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Synthetic Studies Toward Pactamycin Highlighting Oxidative C-H and Alkene Amination Technologies. J Org Chem. 2018 07 06; 83(13):7121-7134.
Su JY, Olson DE, Ting SI, Du Bois J. PMID: 29708344.
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PubMed Mentions:
3 Fields:
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Effects of N, N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression. ACS Chem Neurosci. 2018 07 18; 9(7):1582-1590.
Cameron LP, Benson CJ, Dunlap LE, Olson DE. PMID: 29664276; PMCID: PMC7196340.
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PubMed Mentions:
43 Fields:
Translation:
Animals
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An Ecoregion-Based Approach to Protecting Half the Terrestrial Realm. Bioscience. 2017 Jun 01; 67(6):534-545.
Dinerstein E, Olson D, Joshi A, Vynne C, Burgess ND, Wikramanayake E, Hahn N, Palminteri S, Hedao P, Noss R, Hansen M, Locke H, Ellis EC, Jones B, Barber CV, Hayes R, Kormos C, Martin V, Crist E, Sechrest W, Price L, Baillie JEM, Weeden D, Suckling K, Davis C, Sizer N, Moore R, Thau D, Birch T, Potapov P, Turubanova S, Tyukavina A, de Souza N, Pintea L, Brito JC, Llewellyn OA, Miller AG, Patzelt A, Ghazanfar SA, Timberlake J, Kl?ser H, Shennan-Farp?n Y, Kindt R, Lilles? JB, van Breugel P, Graudal L, Voge M, Al-Shammari KF, Saleem M. PMID: 28608869; PMCID: PMC5451287.
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PubMed Mentions:
151 Fields:
Translation:
Humans
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Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol. 2016 07 15; 11(7):1952-63.
Wagner FF, Bishop JA, Gale JP, Shi X, Walk M, Ketterman J, Patnaik D, Barker D, Walpita D, Campbell AJ, Nguyen S, Lewis M, Ross L, We?wer M, An WF, Germain AR, Nag PP, Metkar S, Kaya T, Dandapani S, Olson DE, Barbe AL, Lazzaro F, Sacher JR, Cheah JH, Fei D, Perez J, Munoz B, Palmer M, Stegmaier K, Schreiber SL, Scolnick E, Zhang YL, Haggarty SJ, Holson EB, Pan JQ. PMID: 27128528.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimals
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Inhibition of DYRK1A Stimulates Human �-Cell Proliferation. Diabetes. 2016 06; 65(6):1660-71.
Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Danc?k V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. PMID: 26953159; PMCID: PMC4878416.
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PubMed Mentions:
88 Fields:
Translation:
HumansAnimalsCells
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Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice. Endocrinology. 2015 Oct; 156(10):3828-41.
Wahid HH, Dorian CL, Chin PY, Hutchinson MR, Rice KC, Olson DM, Moldenhauer LM, Robertson SA. PMID: 26151355; PMCID: PMC4588813.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism. Chem Biol. 2015 Apr 23; 22(4):439-445.
Olson DE, Sleiman SF, Bourassa MW, Wagner FF, Gale JP, Zhang YL, Ratan RR, Holson EB. PMID: 25892200; PMCID: PMC4562013.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Vasoactive intestinal polypeptide (VIP)-expressing neurons in the suprachiasmatic nucleus provide sparse GABAergic outputs to local neurons with circadian regulation occurring distal to the opening of postsynaptic GABAA ionotropic receptors. J Neurosci. 2015 Feb 04; 35(5):1905-20.
Fan J, Zeng H, Olson DP, Huber KM, Gibson JR, Takahashi JS. PMID: 25653351; PMCID: PMC4315827.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Control of food intake and energy expenditure by Nos1 neurons of the paraventricular hypothalamus. J Neurosci. 2014 Nov 12; 34(46):15306-18.
Sutton AK, Pei H, Burnett KH, Myers MG, Rhodes CJ, Olson DP. PMID: 25392498; PMCID: PMC4228133.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition. J Neurosci. 2014 Oct 22; 34(43):14328-37.
Sleiman SF, Olson DE, Bourassa MW, Karuppagounder SS, Zhang YL, Gale J, Wagner FF, Basso M, Coppola G, Pinto JT, Holson EB, Ratan RR. PMID: 25339746; PMCID: PMC4205555.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Vicinal diamination of alkenes under Rh-catalysis. J Am Chem Soc. 2014 Oct 01; 136(39):13506-9.
Olson DE, Su JY, Roberts DA, Du Bois J. PMID: 25233140; PMCID: PMC4183635.
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PubMed Mentions:
21 Fields:
Translation:
Cells
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An unbiased approach to identify endogenous substrates of "histone" deacetylase 8. ACS Chem Biol. 2014 Oct 17; 9(10):2210-6.
Olson DE, Udeshi ND, Wolfson NA, Pitcairn CA, Sullivan ED, Jaffe JD, Svinkina T, Natoli T, Lu X, Paulk J, McCarren P, Wagner FF, Barker D, Howe E, Lazzaro F, Gale JP, Zhang YL, Subramanian A, Fierke CA, Carr SA, Holson EB. PMID: 25089360; PMCID: PMC4201337.
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PubMed Mentions:
45 Fields:
Translation:
HumansCells
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Birthdating of myenteric neuron subtypes in the small intestine of the mouse. J Comp Neurol. 2014 Feb 15; 522(3):514-27.
Bergner AJ, Stamp LA, Gonsalvez DG, Allison MB, Olson DP, Myers MG, Anderson CR, Young HM. PMID: 23861145; PMCID: PMC3877185.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014 Mar 13; 507(7491):238-42.
Krashes MJ, Shah BP, Madara JC, Olson DP, Strochlic DE, Garfield AS, Vong L, Pei H, Watabe-Uchida M, Uchida N, Liberles SD, Lowell BB. PMID: 24487620; PMCID: PMC3955843.
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PubMed Mentions:
291 Fields:
Translation:
AnimalsCells
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Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013 Jun 13; 56(11):4816-20.
Olson DE, Wagner FF, Kaya T, Gale JP, Aidoud N, Davoine EL, Lazzaro F, We?wer M, Zhang YL, Holson EB. PMID: 23672185.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J Med Chem. 2013 Feb 28; 56(4):1772-6.
Wagner FF, Olson DE, Gale JP, Kaya T, We?wer M, Aidoud N, Thomas M, Davoine EL, Lemercier BC, Zhang YL, Holson EB. PMID: 23368884.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Synthesis of differentially substituted 1,2-diamines through advances in C-H amination technology. Org Lett. 2012 Dec 21; 14(24):6174-7.
Olson DE, Roberts DA, Du Bois J. PMID: 23227976.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Synthesis and reactivity of unique heterocyclic structures en route to substituted diamines. Org Lett. 2011 Jul 01; 13(13):3336-9.
Olson DE, Maruniak A, Malhotra S, Trost BM, Du Bois J. PMID: 21618989; PMCID: PMC3123413.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Asymmetric Synthesis of Diamine Derivatives via Sequential Palladium and Rhodium Catalysis. Journal of the American Chemical Society. 2009 Sep 23; 131(37):13563-13563.
Trost TB, Malhotra MS, Olson OD, Maruniak MA, Du Bois DJ. .
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Asymmetric synthesis of diamine derivatives via sequential palladium and rhodium catalysis. J Am Chem Soc. 2009 Apr 01; 131(12):4190-1.
Trost BM, Malhotra S, Olson DE, Maruniak A, Du Bois J. PMID: 19275160; PMCID: PMC3235049.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Catalytic C-H amination for the preparation of substituted 1,2-diamines. J Am Chem Soc. 2008 Aug 27; 130(34):11248-9.
Olson DE, Du Bois J. PMID: 18680286; PMCID: PMC2680474.
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PubMed Mentions:
16 Fields:
Translation:
Cells