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Andrew J Fisher

Title(s)Professor, Chemistry
SchoolUniversity of California, Davis
Phone530-754-6180
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    STRUCTURAL STUDIES OF PROTEINS THAT INHIBIT APOPTOSIS
    NIH/FIC R03TW001219Jan 1, 2000 - Dec 31, 2002
    Role: Principal Investigator
    STRUCTURAL STUDIES OF PROTEINS THAT INHIBIT APOPTOSIS
    NIH/NIGMS R01GM056774Jan 1, 1998 - Dec 31, 2002
    Role: Principal Investigator
    STRUCTURE DETERMINATION OF MYOSIN S1-NUCLEOTIDE COMPLEX
    NIH/NIAMS F32AR008304Jul 31, 1994
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Matthews MM, McArthur JB, Li Y, Yu H, Chen X, Fisher AJ. Catalytic Cycle of Neisseria meningitidis CMP-Sialic Acid Synthetase Illustrated by High-Resolution Protein Crystallography. Biochemistry. 2019 Oct 04. PMID: 31583886.
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    2. Li Y, Li R, Yu H, Sheng X, Wang J, Fisher AJ, Chen X. Enterococcus faecalis a1-2-mannosidase (EfMan-I): an efficient catalyst for glycoprotein N-glycan modification. FEBS Lett. 2019 Sep 25. PMID: 31552675.
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    3. Monteleone LR, Matthews MM, Palumbo CM, Thomas JM, Zheng Y, Chiang Y, Fisher AJ, Beal PA. A Bump-Hole Approach for Directed RNA Editing. Cell Chem Biol. 2019 02 21; 26(2):269-277.e5. PMID: 30581135.
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    4. Hurlburt NK, Chen LH, Stergiopoulos I, Fisher AJ. Structure of the Cladosporium fulvum Avr4 effector in complex with (GlcNAc)6 reveals the ligand-binding mechanism and uncouples its intrinsic function from recognition by the Cf-4 resistance protein. PLoS Pathog. 2018 08; 14(8):e1007263. PMID: 30148881.
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    5. Fisher AJ, Beal PA. Structural basis for eukaryotic mRNA modification. Curr Opin Struct Biol. 2018 12; 53:59-68. PMID: 29913347.
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    6. Lal NK, Nagalakshmi U, Hurlburt NK, Flores R, Bak A, Sone P, Ma X, Song G, Walley J, Shan L, He P, Casteel C, Fisher AJ, Dinesh-Kumar SP. The Receptor-like Cytoplasmic Kinase BIK1 Localizes to the Nucleus and Regulates Defense Hormone Expression during Plant Innate Immunity. Cell Host Microbe. 2018 04 11; 23(4):485-497.e5. PMID: 29649442.
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    7. McArthur JB, Yu H, Tasnima N, Lee CM, Fisher AJ, Chen X. a2-6-Neosialidase: A Sialyltransferase Mutant as a Sialyl Linkage-Specific Sialidase. ACS Chem Biol. 2018 05 18; 13(5):1228-1234. PMID: 29543427.
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    8. Suter SR, Ball-Jones A, Mumbleau MM, Valenzuela R, Ibarra-Soza J, Owens H, Fisher AJ, Beal PA. Controlling miRNA-like off-target effects of an siRNA with nucleobase modifications. Org Biomol Chem. 2017 Dec 06; 15(47):10029-10036. PMID: 29164215.
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    9. Fisher AJ, Beal PA. Effects of Aicardi-Goutières syndrome mutations predicted from ADAR-RNA structures. RNA Biol. 2017 02; 14(2):164-170. PMID: 27937139.
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    10. Lal NK, Fisher AJ, Dinesh-Kumar SP. Arabidopsis receptor-like cytoplasmic kinase BIK1: purification, crystallization and X-ray diffraction analysis. Acta Crystallogr F Struct Biol Commun. 2016 10 01; 72(Pt 10):738-742. PMID: 27710938.
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    11. Kohler AC, Chen LH, Hurlburt N, Salvucci A, Schwessinger B, Fisher AJ, Stergiopoulos I. Structural Analysis of an Avr4 Effector Ortholog Offers Insight into Chitin Binding and Recognition by the Cf-4 Receptor. Plant Cell. 2016 08; 28(8):1945-65. PMID: 27401545.
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    12. Matthews MM, Thomas JM, Zheng Y, Tran K, Phelps KJ, Scott AI, Havel J, Fisher AJ, Beal PA. Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat Struct Mol Biol. 2016 05; 23(5):426-33. PMID: 27065196.
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    13. Erickson AI, Sarsam RD, Fisher AJ. Crystal Structures of Mycobacterium tuberculosis CysQ, with Substrate and Products Bound. Biochemistry. 2015 Nov 17; 54(45):6830-41. PMID: 26512869.
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    14. Ngo A, Fong KT, Cox DL, Chen X, Fisher AJ. Structures of Bacteroides fragilis uridine 5'-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (BfLpxA). Acta Crystallogr D Biol Crystallogr. 2015 May; 71(Pt 5):1068-76. PMID: 25945572.
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    15. Phelps KJ, Tran K, Eifler T, Erickson AI, Fisher AJ, Beal PA. Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2. Nucleic Acids Res. 2015 Jan; 43(2):1123-32. PMID: 25564529.
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    16. Huynh N, Li Y, Yu H, Huang S, Lau K, Chen X, Fisher AJ. Crystal structures of sialyltransferase from Photobacterium damselae. FEBS Lett. 2014 Dec 20; 588(24):4720-9. PMID: 25451227.
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    17. Phelps KJ, Ibarra-Soza JM, Tran K, Fisher AJ, Beal PA. Click modification of RNA at adenosine: structure and reactivity of 7-ethynyl- and 7-triazolyl-8-aza-7-deazaadenosine in RNA. ACS Chem Biol. 2014 Aug 15; 9(8):1780-7. PMID: 24896732.
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    18. Erickson AI, Sarsam RD, Fisher AJ. Expression, purification and preliminary crystallographic analysis of Mycobacterium tuberculosis CysQ, a phosphatase involved in sulfur metabolism. Acta Crystallogr F Struct Biol Commun. 2014 Jun; 70(Pt 6):750-3. PMID: 24915085.
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    19. Huynh N, Aye A, Li Y, Yu H, Cao H, Tiwari VK, Shin DW, Chen X, Fisher AJ. Structural basis for substrate specificity and mechanism of N-acetyl-D-neuraminic acid lyase from Pasteurella multocida. Biochemistry. 2013 Nov 26; 52(47):8570-9. PMID: 24152047.
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    20. Kabasakal BV, Gae DD, Li J, Lagarias JC, Koehl P, Fisher AJ. His74 conservation in the bilin reductase PcyA family reflects an important role in protein-substrate structure and dynamics. Arch Biochem Biophys. 2013 Sep 15; 537(2):233-42. PMID: 23911721.
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    21. Addington TA, Mertz RW, Siegel JB, Thompson JM, Fisher AJ, Filkov V, Fleischman NM, Suen AA, Zhang C, Toney MD. Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J Mol Biol. 2013 Apr 26; 425(8):1378-89. PMID: 23396064.
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    22. Sugiarto G, Lau K, Qu J, Li Y, Lim S, Mu S, Ames JB, Fisher AJ, Chen X. A sialyltransferase mutant with decreased donor hydrolysis and reduced sialidase activities for directly sialylating LewisX. ACS Chem Biol. 2012 Jul 20; 7(7):1232-40. PMID: 22583967.
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    23. Griswold WR, Castro JN, Fisher AJ, Toney MD. Ground-state electronic destabilization via hyperconjugation in aspartate aminotransferase. J Am Chem Soc. 2012 May 23; 134(20):8436-8. PMID: 22551424.
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    24. Griswold WR, Fisher AJ, Toney MD. Crystal structures of aspartate aminotransferase reconstituted with 1-deazapyridoxal 5'-phosphate: internal aldimine and stable L-aspartate external aldimine. Biochemistry. 2011 Jul 05; 50(26):5918-24. PMID: 21627105.
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    25. Kohler AC, Gae DD, Richley MA, Stoll S, Gunn A, Lim S, Martin SS, Doukov TI, Britt RD, Ames JB, Lagarias JC, Fisher AJ. Structural basis for hydration dynamics in radical stabilization of bilin reductase mutants. Biochemistry. 2010 Jul 27; 49(29):6206-18. PMID: 20557110.
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    26. Gay SC, Segel IH, Fisher AJ. Structure of the two-domain hexameric APS kinase from Thiobacillus denitrificans: structural basis for the absence of ATP sulfurylase activity. Acta Crystallogr D Biol Crystallogr. 2009 Oct; 65(Pt 10):1021-31. PMID: 19770499.
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    27. Gay SC, Fribourgh JL, Donohoue PD, Segel IH, Fisher AJ. Kinetic properties of ATP sulfurylase and APS kinase from Thiobacillus denitrificans. Arch Biochem Biophys. 2009 Sep; 489(1-2):110-7. PMID: 19664586.
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    28. Stoll S, Gunn A, Brynda M, Sughrue W, Kohler AC, Ozarowski A, Fisher AJ, Lagarias JC, Britt RD. Structure of the biliverdin radical intermediate in phycocyanobilin:ferredoxin oxidoreductase identified by high-field EPR and DFT. J Am Chem Soc. 2009 Feb 11; 131(5):1986-95. PMID: 19159240.
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    29. Yu Z, Lemongello D, Segel IH, Fisher AJ. Crystal structure of Saccharomyces cerevisiae 3'-phosphoadenosine-5'-phosphosulfate reductase complexed with adenosine 3',5'-bisphosphate. Biochemistry. 2008 Dec 02; 47(48):12777-86. PMID: 18991405.
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    30. Mohanty AK, Fisher AJ, Yu Z, Pradeep MA, Janjanam J, Kaushik JK. Cloning, expression, characterization and crystallization of BRP39, a signalling glycoprotein expressed during mammary gland apoptosis. Protein Expr Purif. 2009 Apr; 64(2):213-8. PMID: 19041398.
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    31. Wingard JN, Ladner J, Vanarotti M, Fisher AJ, Robinson H, Buchanan KT, Engman DM, Ames JB. Structural insights into membrane targeting by the flagellar calcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensor in Trypanosoma cruzi. J Biol Chem. 2008 Aug 22; 283(34):23388-96. PMID: 18559337.
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    32. Ni L, Chokhawala HA, Cao H, Henning R, Ng L, Huang S, Yu H, Chen X, Fisher AJ. Crystal structures of Pasteurella multocida sialyltransferase complexes with acceptor and donor analogues reveal substrate binding sites and catalytic mechanism. Biochemistry. 2007 May 29; 46(21):6288-98. PMID: 17487984.
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    33. Murata K, Fisher AJ, Hedrick JL. Crystallization and X-ray analysis of the salmon-egg lectin SEL24K. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 01; 63(Pt 5):396-8. PMID: 17565179.
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    34. Tu SL, Rockwell NC, Lagarias JC, Fisher AJ. Insight into the radical mechanism of phycocyanobilin-ferredoxin oxidoreductase (PcyA) revealed by X-ray crystallography and biochemical measurements. Biochemistry. 2007 Feb 13; 46(6):1484-94. PMID: 17279614.
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    35. Yu Z, Lansdon EB, Segel IH, Fisher AJ. Crystal structure of the bifunctional ATP sulfurylase-APS kinase from the chemolithotrophic thermophile Aquifex aeolicus. J Mol Biol. 2007 Jan 19; 365(3):732-43. PMID: 17095009.
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    36. Ni L, Sun M, Yu H, Chokhawala H, Chen X, Fisher AJ. Cytidine 5'-monophosphate (CMP)-induced structural changes in a multifunctional sialyltransferase from Pasteurella multocida. Biochemistry. 2006 Feb 21; 45(7):2139-48. PMID: 16475803.
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    37. Liu W, Peterson PE, Langston JA, Jin X, Zhou X, Fisher AJ, Toney MD. Kinetic and crystallographic analysis of active site mutants of Escherichia coli gamma-aminobutyrate aminotransferase. Biochemistry. 2005 Mar 01; 44(8):2982-92. PMID: 15723541.
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    38. Liu W, Peterson PE, Carter RJ, Zhou X, Langston JA, Fisher AJ, Toney MD. Crystal structures of unbound and aminooxyacetate-bound Escherichia coli gamma-aminobutyrate aminotransferase. Biochemistry. 2004 Aug 31; 43(34):10896-905. PMID: 15323550.
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    39. Lansdon EB, Fisher AJ, Segel IH. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains. Biochemistry. 2004 Apr 13; 43(14):4356-65. PMID: 15065880.
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    40. Corneillie TM, Fisher AJ, Meares CF. Crystal structures of two complexes of the rare-earth-DOTA-binding antibody 2D12.5: ligand generality from a chiral system. J Am Chem Soc. 2003 Dec 10; 125(49):15039-48. PMID: 14653738.
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    41. Forsyth CM, Lemongello D, LaCount DJ, Friesen PD, Fisher AJ. Crystal structure of an invertebrate caspase. J Biol Chem. 2004 Feb 20; 279(8):7001-8. PMID: 14645217.
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    42. Hanna E, Ng KF, MacRae IJ, Bley CJ, Fisher AJ, Segel IH. Kinetic and stability properties of Penicillium chrysogenum ATP sulfurylase missing the C-terminal regulatory domain. J Biol Chem. 2004 Feb 06; 279(6):4415-24. PMID: 14613928.
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    43. Corneillie TM, Whetstone PA, Fisher AJ, Meares CF. A rare earth-DOTA-binding antibody: probe properties and binding affinity across the lanthanide series. J Am Chem Soc. 2003 Mar 26; 125(12):3436-7. PMID: 12643698.
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    44. MacRae IJ, Segel IH, Fisher AJ. Allosteric inhibition via R-state destabilization in ATP sulfurylase from Penicillium chrysogenum. Nat Struct Biol. 2002 Dec; 9(12):945-9. PMID: 12426581.
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    45. Lansdon EB, Segel IH, Fisher AJ. Ligand-induced structural changes in adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum. Biochemistry. 2002 Nov 19; 41(46):13672-80. PMID: 12427029.
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    46. Liu W, Rogers CJ, Fisher AJ, Toney MD. Aminophosphonate inhibitors of dialkylglycine decarboxylase: structural basis for slow binding inhibition. Biochemistry. 2002 Oct 15; 41(41):12320-8. PMID: 12369820.
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    47. Hanna E, MacRae IJ, Medina DC, Fisher AJ, Segel IH. ATP sulfurylase from the hyperthermophilic chemolithotroph Aquifex aeolicus. Arch Biochem Biophys. 2002 Oct 15; 406(2):275-88. PMID: 12361716.
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    48. Eddins MJ, Lemongello D, Friesen PD, Fisher AJ. Crystallization and low-resolution structure of an effector-caspase/P35 complex: similarities and differences to an initiator-caspase/P35 complex. Acta Crystallogr D Biol Crystallogr. 2002 Feb; 58(Pt 2):299-302. PMID: 11807256.
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    49. Beynon JD, MacRae IJ, Huston SL, Nelson DC, Segel IH, Fisher AJ. Crystal structure of ATP sulfurylase from the bacterial symbiont of the hydrothermal vent tubeworm Riftia pachyptila. Biochemistry. 2001 Dec 04; 40(48):14509-17. PMID: 11724564.
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    50. Medina DC, Hanna E, MacRae IJ, Fisher AJ, Segel IH. Temperature effects on the allosteric transition of ATP sulfurylase from Penicillium chrysogenum. Arch Biochem Biophys. 2001 Sep 01; 393(1):51-60. PMID: 11516160.
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    51. Mogilner A, Fisher AJ, Baskin RJ. Structural changes in the neck linker of kinesin explain the load dependence of the motor's mechanical cycle. J Theor Biol. 2001 Jul 21; 211(2):143-57. PMID: 11419956.
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    52. MacRae IJ, Segel IH, Fisher AJ. Crystal structure of ATP sulfurylase from Penicillium chrysogenum: insights into the allosteric regulation of sulfate assimilation. Biochemistry. 2001 Jun 12; 40(23):6795-804. PMID: 11389593.
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    53. dela Cruz WP, Friesen PD, Fisher AJ. Crystal structure of baculovirus P35 reveals a novel conformational change in the reactive site loop after caspase cleavage. J Biol Chem. 2001 Aug 31; 276(35):32933-9. PMID: 11402050.
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    54. Beynon J, Rafanan ER, Shen B, Fisher AJ. Crystallization and preliminary X-ray analysis of tetracenomycin A2 oxygenase: a flavoprotein hydroxylase involved in polyketide biosynthesis. Acta Crystallogr D Biol Crystallogr. 2000 Dec; 56(Pt 12):1647-51. PMID: 11092935.
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    55. MacRae IJ, Hanna E, Ho JD, Fisher AJ, Segel IH. Induction of positive cooperativity by amino acid replacements within the C-terminal domain of Penicillium chrysogenum ATP sulfurylase. J Biol Chem. 2000 Nov 17; 275(46):36303-10. PMID: 10956658.
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    56. MacRae IJ, Segel IH, Fisher AJ. Crystal structure of adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum. Biochemistry. 2000 Feb 22; 39(7):1613-21. PMID: 10677210.
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    57. Fisher AJ, Cruz Wd, Zoog SJ, Schneider CL, Friesen PD. Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition. EMBO J. 1999 Apr 15; 18(8):2031-9. PMID: 10205157.
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    58. Rao-Naik C, delaCruz W, Laplaza JM, Tan S, Callis J, Fisher AJ. The rub family of ubiquitin-like proteins. Crystal structure of Arabidopsis rub1 and expression of multiple rubs in Arabidopsis. J Biol Chem. 1998 Dec 25; 273(52):34976-82. PMID: 9857029.
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    59. Thoden JB, Holden HM, Fisher AJ, Sinclair JF, Wesenberg G, Baldwin TO, Rayment I. Structure of the beta 2 homodimer of bacterial luciferase from Vibrio harveyi: X-ray analysis of a kinetic protein folding trap. Protein Sci. 1997 Jan; 6(1):13-23. PMID: 9007973.
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    60. Fisher AJ, Thompson TB, Thoden JB, Baldwin TO, Rayment I. The 1.5-A resolution crystal structure of bacterial luciferase in low salt conditions. J Biol Chem. 1996 Sep 06; 271(36):21956-68. PMID: 8703001.
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    61. Baldwin TO, Christopher JA, Raushel FM, Sinclair JF, Ziegler MM, Fisher AJ, Rayment I. Structure of bacterial luciferase. Curr Opin Struct Biol. 1995 Dec; 5(6):798-809. PMID: 8749369.
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    62. Fisher AJ, Smith CA, Thoden JB, Smith R, Sutoh K, Holden HM, Rayment I. X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-. Biochemistry. 1995 Jul 18; 34(28):8960-72. PMID: 7619795.
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    63. Fisher AJ, Raushel FM, Baldwin TO, Rayment I. Three-dimensional structure of bacterial luciferase from Vibrio harveyi at 2.4 A resolution. Biochemistry. 1995 May 23; 34(20):6581-6. PMID: 7756289.
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    64. Fisher AJ, Smith CA, Thoden J, Smith R, Sutoh K, Holden HM, Rayment I. Structural studies of myosin:nucleotide complexes: a revised model for the molecular basis of muscle contraction. Biophys J. 1995 Apr; 68(4 Suppl):19S-26S; discussion 27S-28S. PMID: 7787065.
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    65. Cheng RH, Reddy VS, Olson NH, Fisher AJ, Baker TS, Johnson JE. Functional implications of quasi-equivalence in a T = 3 icosahedral animal virus established by cryo-electron microscopy and X-ray crystallography. Structure. 1994 Apr 15; 2(4):271-82. PMID: 8087554.
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    66. Johnson JE, Munshi S, Liljas L, Agrawal D, Olson NH, Reddy V, Fisher A, McKinney B, Schmidt T, Baker TS. Comparative studies of T = 3 and T = 4 icosahedral RNA insect viruses. Arch Virol Suppl. 1994; 9:497-512. PMID: 8032278.
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    67. Fisher AJ, McKinney BR, Schneemann A, Rueckert RR, Johnson JE. Crystallization of viruslike particles assembled from flock house virus coat protein expressed in a baculovirus system. J Virol. 1993 May; 67(5):2950-3. PMID: 8474184.
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    68. Fisher AJ, Johnson JE. Ordered duplex RNA controls capsid architecture in an icosahedral animal virus. Nature. 1993 Jan 14; 361(6408):176-9. PMID: 8421524.
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    69. Fisher AJ, McKinney BR, Wery JP, Johnson JE. Crystallization and preliminary data analysis of Flock House virus. Acta Crystallogr B. 1992 Aug 01; 48 ( Pt 4):515-20. PMID: 1418822.
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