J. David Furlow

Title(s)Professor, Neurobiology, Physiology and Behavior
SchoolCollege of Biological Sciences
Address1011 Green Hall
CA 95616
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    Collapse Research 
    Collapse Research Activities and Funding
    Retinoid-X receptors: signaling hubs and novel targets of endocrine disruption
    NIH R21ES026271Sep 1, 2016 - Aug 31, 2019
    Role: Principal Investigator
    Glucocorticoid control of gene expression during skeletal muscle atrophy
    NIH R01DK075801Jan 1, 2008 - Nov 30, 2012
    Role: Principal Investigator
    Thyroid hormone control of a gene expression network
    NIH R01DK055511May 15, 1999 - Jan 31, 2010
    Role: Principal Investigator
    NIH F32DK008708Sep 10, 1992
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Prediction of the Interactions of a Large Number of Per- and Poly-Fluoroalkyl Substances with Ten Nuclear Receptors. Environ Sci Technol. 2024 Feb 29. Azhagiya Singam ER, Durkin KA, La Merrill MA, Furlow JD, Wang JC, Smith MT. PMID: 38422483.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. The vitamin D receptor as a potential target for the toxic effects of per- and polyfluoroalkyl substances (PFASs): An in-silico study. Environ Res. 2023 01 15; 217:114832. Azhagiya Singam ER, Durkin KA, La Merrill MA, Furlow JD, Wang JC, Smith MT. PMID: 36403651; PMCID: PMC10044465.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Retinoid-X receptor agonists increase thyroid hormone competence in lower jaw remodeling of pre-metamorphic Xenopus laevis tadpoles. PLoS One. 2022; 17(4):e0266946. Mengeling BJ, Vetter LF, Furlow JD. PMID: 35417489; PMCID: PMC9007347.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. In Vitro characterization of the endocrine disrupting effects of per- and poly-fluoroalkyl substances (PFASs) on the human androgen receptor. J Hazard Mater. 2022 05 05; 429:128243. Tachachartvanich P, Singam ERA, Durkin KA, Furlow JD, Smith MT, La Merrill MA. PMID: 35093747; PMCID: PMC9705075.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. RXR Ligands Modulate Thyroid Hormone Signaling Competence in Young Xenopus laevis Tadpoles. Endocrinology. 2018 07 01; 159(7):2576-2595. Mengeling BJ, Goodson ML, Furlow JD. PMID: 29762675; PMCID: PMC6692881.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    6. A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling. Aquat Toxicol. 2017 Sep; 190:1-10. Mengeling BJ, Wei Y, Dobrawa LN, Streekstra M, Louisse J, Singh V, Singh L, Lein PJ, Wulff H, Murk AJ, Furlow JD. PMID: 28662416; PMCID: PMC5558850.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    7. Regulation of vernal migration in Gambel's white-crowned sparrows: Role of thyroxine and triiodothyronine. Horm Behav. 2016 08; 84:50-6. Pérez JH, Furlow JD, Wingfield JC, Ramenofsky M. PMID: 27234300.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    8. Trialkyltin Rexinoid-X Receptor Agonists Selectively Potentiate Thyroid Hormone Induced Programs of Xenopus laevis Metamorphosis. Endocrinology. 2016 07; 157(7):2712-23. Mengeling BJ, Murk AJ, Furlow JD. PMID: 27167774.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    9. Expanding the genetic toolkit in Xenopus: Approaches and opportunities for human disease modeling. Dev Biol. 2017 06 15; 426(2):325-335. Tandon P, Conlon F, Furlow JD, Horb ME. PMID: 27109192; PMCID: PMC5074924.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    10. Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity. J Org Chem. 2016 Mar 04; 81(5):1870-6. Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V. PMID: 26849160.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    11. Pituitary specific retinoid-X receptor ligand interactions with thyroid hormone receptor signaling revealed by high throughput reporter and endogenous gene responses. Toxicol In Vitro. 2015 Oct; 29(7):1609-18. Mengeling BJ, Furlow JD. PMID: 26096596.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. Glucocorticoids and Skeletal Muscle. Adv Exp Med Biol. 2015; 872:145-76. Bodine SC, Furlow JD. PMID: 26215994.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
    13. Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform. Curr Chem Genom Transl Med. 2014; 8:36-46. Freitas J, Miller N, Mengeling BJ, Xia M, Huang R, Houck K, Rietjens IM, Furlow JD, Murk AJ. PMID: 24772387; PMCID: PMC3999704.
      View in: PubMed   Mentions: 11  
    14. Altered gene expression patterns in muscle ring finger 1 null mice during denervation- and dexamethasone-induced muscle atrophy. Physiol Genomics. 2013 Dec 01; 45(23):1168-85. Furlow JD, Watson ML, Waddell DS, Neff ES, Baehr LM, Ross AP, Bodine SC. PMID: 24130153; PMCID: PMC3882710.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    15. Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals. Toxicol In Vitro. 2013 Jun; 27(4):1320-46. Murk AJ, Rijntjes E, Blaauboer BJ, Clewell R, Crofton KM, Dingemans MM, Furlow JD, Kavlock R, Köhrle J, Opitz R, Traas T, Visser TJ, Xia M, Gutleb AC. PMID: 23453986.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    16. Upregulation of proteasome activity in muscle RING finger 1-null mice following denervation. FASEB J. 2012 Jul; 26(7):2986-99. Gomes AV, Waddell DS, Siu R, Stein M, Dewey S, Furlow JD, Bodine SC. PMID: 22508689; PMCID: PMC3382096.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    17. A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure. Am J Physiol Endocrinol Metab. 2012 May 01; 302(10):E1210-20. Watson ML, Baehr LM, Reichardt HM, Tuckermann JP, Bodine SC, Furlow JD. PMID: 22354783; PMCID: PMC3361985.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    18. A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med. 2012 Apr 15; 185(8):825-34. Files DC, D'Alessio FR, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tankersley CG, Messi ML, Liu C, Delbono O, Furlow JD, Bodine SC, Cohn RD, King LS, Crow MT. PMID: 22312013; PMCID: PMC3360571.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    19. Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids. J Physiol. 2011 Oct 01; 589(Pt 19):4759-76. Baehr LM, Furlow JD, Bodine SC. PMID: 21807613; PMCID: PMC3213422.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    20. Detection of thyroid hormone receptor disruptors by a novel stable in vitro reporter gene assay. Toxicol In Vitro. 2011 Feb; 25(1):257-66. Freitas J, Cano P, Craig-Veit C, Goodson ML, Furlow JD, Murk AJ. PMID: 20732405.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    21. Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. Cancer Res. 2009 Jan 01; 69(1):128-36. Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I. PMID: 19117995; PMCID: PMC2713826.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    22. Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevis. Dev Biol. 2009 Feb 01; 326(1):155-68. Denver RJ, Hu F, Scanlan TS, Furlow JD. PMID: 19056375.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    23. The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E785-97. Waddell DS, Baehr LM, van den Brandt J, Johnsen SA, Reichardt HM, Furlow JD, Bodine SC. PMID: 18612045; PMCID: PMC2652500.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    24. Thyroid hormone receptor isoform selectivity of thyroid hormone disrupting compounds quantified with an in vitro reporter gene assay. Environ Toxicol Pharmacol. 2007 May; 23(3):302-7. Schriks M, Roessig JM, Murk AJ, Furlow JD. PMID: 21783772.
      View in: PubMed   Mentions: 12     Fields:    
    25. Disruption of thyroid hormone-mediated Xenopus laevis tadpole tail tip regression by hexabromocyclododecane (HBCD) and 2,2',3,3',4,4',5,5',6-nona brominated diphenyl ether (BDE206). Chemosphere. 2006 Dec; 65(10):1904-8. Schriks M, Zvinavashe E, Furlow JD, Murk AJ. PMID: 16996109.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    26. Measurement of the filtration coefficient (Kfc) in the lung of Gallus domesticus and the effects of increased microvascular permeability. J Comp Physiol B. 2006 Aug; 176(6):567-74. Weidner WJ, Waddell DS, Furlow JD. PMID: 16538461.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    27. A developmental switch induced by thyroid hormone: Xenopus laevis metamorphosis. Trends Endocrinol Metab. 2006 Mar; 17(2):40-7. Furlow JD, Neff ES. PMID: 16464605.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    28. The mouse muscle creatine kinase promoter faithfully drives reporter gene expression in transgenic Xenopus laevis. Physiol Genomics. 2004 Jun 17; 18(1):79-86. Lim W, Neff ES, Furlow JD. PMID: 15010518.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    29. Spatiotemporal retinoid-X receptor activation detected in live vertebrate embryos. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):8987-92. Luria A, Furlow JD. PMID: 15178767; PMCID: PMC428459.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    30. Induction of larval tissue resorption in Xenopus laevis tadpoles by the thyroid hormone receptor agonist GC-1. J Biol Chem. 2004 Jun 18; 279(25):26555-62. Furlow JD, Yang HY, Hsu M, Lim W, Ermio DJ, Chiellini G, Scanlan TS. PMID: 15056670.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    31. The transcription factor basic transcription element-binding protein 1 is a direct thyroid hormone response gene in the frog Xenopus laevis. Endocrinology. 2002 Sep; 143(9):3295-305. Furlow JD, Kanamori A. PMID: 12193541.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    32. Ribozyme suppression of endogenous thyroid hormone receptor activity in Xenopus laevis cells. Nucleic Acids Res. 2002 Aug 01; 30(15):3490-6. Lim W, Furlow JD. PMID: 12140335; PMCID: PMC137085.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    33. A thyroid hormone antagonist that inhibits thyroid hormone action in vivo. J Biol Chem. 2002 Sep 20; 277(38):35664-70. Lim W, Nguyen NH, Yang HY, Scanlan TS, Furlow JD. PMID: 12095994.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    34. Selective modulation of thyroid hormone receptor action. J Steroid Biochem Mol Biol. 2001 Jan-Mar; 76(1-5):31-42. Baxter JD, Dillmann WH, West BL, Huber R, Furlow JD, Fletterick RJ, Webb P, Apriletti JW, Scanlan TS. PMID: 11384861.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    35. In vitro and in vivo analysis of the regulation of a transcription factor gene by thyroid hormone during Xenopus laevis metamorphosis. Mol Endocrinol. 1999 Dec; 13(12):2076-89. Furlow JD, Brown DD. PMID: 10598583.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    36. A set of novel tadpole specific genes expressed only in the epidermis are down-regulated by thyroid hormone during Xenopus laevis metamorphosis. Dev Biol. 1997 Feb 15; 182(2):284-98. Furlow JD, Berry DL, Wang Z, Brown DD. PMID: 9070328.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    37. The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis. Proc Natl Acad Sci U S A. 1996 Mar 05; 93(5):1924-9. Brown DD, Wang Z, Furlow JD, Kanamori A, Schwartzman RA, Remo BF, Pinder A. PMID: 8700860; PMCID: PMC39884.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    38. Estrogen receptor binding to DNA: affinity for nonpalindromic elements from the rat prolactin gene. Biochemistry. 1995 Jul 18; 34(28):9144-50. Murdoch FE, Byrne LM, Ariazi EA, Furlow JD, Meier DA, Gorski J. PMID: 7619813.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    39. Amphibian metamorphosis: a complex program of gene expression changes controlled by the thyroid hormone. Recent Prog Horm Res. 1995; 50:309-15. Brown DD, Wang Z, Kanamori A, Eliceiri B, Furlow JD, Schwartzman R. PMID: 7740163.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    40. Involvement of the coding sequence for the estrogen receptor gene in autologous ligand-dependent down-regulation. Mol Endocrinol. 1993 Jul; 7(7):879-88. Kaneko KJ, Furlow JD, Gorski J. PMID: 8413312.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    41. High affinity binding of the estrogen receptor to a DNA response element does not require homodimer formation or estrogen. J Biol Chem. 1993 Jun 15; 268(17):12519-25. Furlow JD, Murdoch FE, Gorski J. PMID: 8509392.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    42. Perturbations in the model of estrogen receptor regulation of gene expression. Biol Reprod. 1993 Jan; 48(1):8-14. Gorski J, Furlow JD, Murdoch FE, Fritsch M, Kaneko K, Ying C, Malayer JR. PMID: 8418919.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    43. A ligand-induced conformational change in the estrogen receptor is localized in the steroid binding domain. Biochemistry. 1992 Jun 16; 31(23):5303-11. Fritsch M, Leary CM, Furlow JD, Ahrens H, Schuh TJ, Mueller GC, Gorski J. PMID: 1606154.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    44. Overproduction of full-length and truncated human estrogen receptors in Escherichia coli. Receptor. 1992; 2(2):77-92. Ahrens H, Schuh TJ, Rainish BL, Furlow JD, Gorski J, Mueller GC. PMID: 1472947.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    45. Immunodetection of estrogen receptors in fetal and neonatal male mouse reproductive tracts. Endocrinology. 1992 Jan; 130(1):421-9. Greco TL, Furlow JD, Duello TM, Gorski J. PMID: 1727715.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    46. Immunodetection of estrogen receptors in fetal and neonatal female mouse reproductive tracts. Endocrinology. 1991 Sep; 129(3):1326-32. Greco TL, Furlow JD, Duello TM, Gorski J. PMID: 1874174.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    47. An estrogen-responsive element mediates the transcriptional regulation of calbindin D-9K gene in rat uterus. J Biol Chem. 1991 Jan 05; 266(1):551-8. Darwish H, Krisinger J, Furlow JD, Smith C, Murdoch FE, DeLuca HF. PMID: 1985915.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    48. Estrogen receptor binding to a DNA response element in vitro is not dependent upon estradiol. Biochemistry. 1990 Sep 11; 29(36):8377-85. Murdoch FE, Meier DA, Furlow JD, Grunwald KA, Gorski J. PMID: 2252899.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    49. Antisera to a synthetic peptide recognize native and denatured rat estrogen receptors. Endocrinology. 1990 Sep; 127(3):1028-32. Furlow JD, Ahrens H, Mueller GC, Gorski J. PMID: 2201530.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells