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Tsung-Yu Chen, MD; PhD

Title(s)Professor, Neurology
SchoolUniversity of California, Davis
Phone530-754-7166
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Xu P, Choo YM, Chen Z, Zeng F, Tan K, Chen TY, Cornel AJ, Liu N, Leal WS. Odorant Inhibition in Mosquito Olfaction. iScience. 2019 Sep 27; 19:25-38. PMID: 31349189.
      View in: PubMed
    2. Nguyen DM, Chen LS, Yu WP, Chen TY. Comparison of ion transport determinants between a TMEM16 chloride channel and phospholipid scramblase. J Gen Physiol. 2019 Apr 01; 151(4):518-531. PMID: 30670476.
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    3. Peng YJ, Lee YC, Fu SJ, Chien YC, Liao YF, Chen TY, Jeng CJ, Tang CY. FKBP8 Enhances Protein Stability of the CLC-1 Chloride Channel at the Plasma Membrane. Int J Mol Sci. 2018 Nov 28; 19(12). PMID: 30487393.
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    4. O'Halloran DM, Altshuler-Keylin S, Zhang XD, He C, Morales-Phan C, Yu Y, Kaye JA, Brueggemann C, Chen TY, L'Etoile ND. Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans. Sci Rep. 2017 03 13; 7(1):169. PMID: 28279024.
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    5. Jeng G, Aggarwal M, Yu WP, Chen TY. Independent activation of distinct pores in dimeric TMEM16A channels. J Gen Physiol. 2016 11; 148(5):393-404. PMID: 27799319.
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    6. Peng YJ, Huang JJ, Wu HH, Hsieh HY, Wu CY, Chen SC, Chen TY, Tang CY. Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90ß. Sci Rep. 2016 09 01; 6:32444. PMID: 27580824.
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    7. Pedersen TH, Riisager A, de Paoli FV, Chen TY, Nielsen OB. Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. J Gen Physiol. 2016 Apr; 147(4):291-308. PMID: 27022190.
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    8. Riisager A, de Paoli FV, Yu WP, Pedersen TH, Chen TY, Nielsen OB. Protein kinase C-dependent regulation of ClC-1 channels in active human muscle and its effect on fast and slow gating. J Physiol. 2016 06 15; 594(12):3391-406. PMID: 26857341.
      View in: PubMed
    9. Yu Y, Tsai MF, Yu WP, Chen TY. Modulation of the slow/common gating of CLC channels by intracellular cadmium. J Gen Physiol. 2015 Dec; 146(6):495-508. PMID: 26621774.
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    10. Chen YA, Peng YJ, Hu MC, Huang JJ, Chien YC, Wu JT, Chen TY, Tang CY. The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels. Sci Rep. 2015 May 29; 5:10667. PMID: 26021757.
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    11. Yu Y, Chen TY. Purified human brain calmodulin does not alter the bicarbonate permeability of the ANO1/TMEM16A channel. J Gen Physiol. 2015 Jan; 145(1):79-81. PMID: 25548138.
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    12. Yu Y, Kuan AS, Chen TY. Calcium-calmodulin does not alter the anion permeability of the mouse TMEM16A calcium-activated chloride channel. J Gen Physiol. 2014 Jul; 144(1):115-24. PMID: 24981232.
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    13. Ni YL, Kuan AS, Chen TY. Activation and inhibition of TMEM16A calcium-activated chloride channels. PLoS One. 2014; 9(1):e86734. PMID: 24489780.
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    14. Lee TT, Zhang XD, Chuang CC, Chen JJ, Chen YA, Chen SC, Chen TY, Tang CY. Myotonia congenita mutation enhances the degradation of human CLC-1 chloride channels. PLoS One. 2013; 8(2):e55930. PMID: 23424641.
      View in: PubMed
    15. Chen TY. Single myotonia mutation strikes multiple mechanisms of a chloride channel. J Physiol. 2012 Aug 01; 590(15):3407. PMID: 22855049.
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    16. Richman DP, Yu Y, Lee TT, Tseng PY, Yu WP, Maselli RA, Tang CY, Chen TY. Dominantly inherited myotonia congenita resulting from a mutation that increases open probability of the muscle chloride channel CLC-1. Neuromolecular Med. 2012 Dec; 14(4):328-37. PMID: 22790975.
      View in: PubMed
    17. Bennetts B, Yu Y, Chen TY, Parker MW. Intracellular ß-nicotinamide adenine dinucleotide inhibits the skeletal muscle ClC-1 chloride channel. J Biol Chem. 2012 Jul 27; 287(31):25808-20. PMID: 22689570.
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    18. Yu T, Wang XQ, Sang JP, Pan CX, Zou XW, Chen TY, Zou X. Influences of mutations on the electrostatic binding free energies of chloride ions in Escherichia coli ClC. J Phys Chem B. 2012 Jun 07; 116(22):6431-8. PMID: 22612693.
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    19. Tang CY, Chen TY. Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia. J Biomed Biotechnol. 2011; 2011:685328. PMID: 22187529.
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    20. Tseng PY, Yu WP, Liu HY, Zhang XD, Zou X, Chen TY. Binding of ATP to the CBS domains in the C-terminal region of CLC-1. J Gen Physiol. 2011 Apr; 137(4):357-68. PMID: 21444658.
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    21. Harley W, Floyd C, Dunn T, Zhang XD, Chen TY, Hegde M, Palandoken H, Nantz MH, Leon L, Carraway KL, Lyeth B, Gorin FA. Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas. Brain Res. 2010 Dec 02; 1363:159-69. PMID: 20869350.
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    22. Wang XQ, Yu T, Sang JP, Zou XW, Chen TY, Bolser D, Zou X. A three-state multi-ion kinetic model for conduction properties of ClC-0 chloride channel. Biophys J. 2010 Jul 21; 99(2):464-71. PMID: 20643064.
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    23. Cao L, Zhang XD, Liu X, Chen TY, Zhao M. Chloride channels and transporters in human corneal epithelium. Exp Eye Res. 2010 Jun; 90(6):771-9. PMID: 20346358.
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    24. Zhang XD, Yu WP, Chen TY. Accessibility of the CLC-0 pore to charged methanethiosulfonate reagents. Biophys J. 2010 Feb 03; 98(3):377-85. PMID: 20141750.
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    25. Zhang XD, Tseng PY, Yu WP, Chen TY. Blocking pore-open mutants of CLC-0 by amphiphilic blockers. J Gen Physiol. 2009 Jan; 133(1):43-58. PMID: 19088381.
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    26. Zhang XD, Chen TY. Amphiphilic blockers punch through a mutant CLC-0 pore. J Gen Physiol. 2009 Jan; 133(1):59-68. PMID: 19088382.
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    27. Yi YH, Ho PY, Chen TW, Lin WJ, Gukassyan V, Tsai TH, Wang DW, Lew TS, Tang CY, Lo SJ, Chen TY, Kao FJ, Lin CH. Membrane targeting and coupling of NHE1-integrinalphaIIbbeta3-NCX1 by lipid rafts following integrin-ligand interactions trigger Ca2+ oscillations. J Biol Chem. 2009 Feb 06; 284(6):3855-64. PMID: 18996841.
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    28. Zhang XD, Tseng PY, Chen TY. ATP inhibition of CLC-1 is controlled by oxidation and reduction. J Gen Physiol. 2008 Oct; 132(4):421-8. PMID: 18824589.
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    29. Chen TY, Hwang TC. CLC-0 and CFTR: chloride channels evolved from transporters. Physiol Rev. 2008 Apr; 88(2):351-87. PMID: 18391167.
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    30. Tseng PY, Bennetts B, Chen TY. Cytoplasmic ATP inhibition of CLC-1 is enhanced by low pH. J Gen Physiol. 2007 Aug; 130(2):217-21. PMID: 17664348.
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    31. Bykova EA, Zhang XD, Chen TY, Zheng J. Large movement in the C terminus of CLC-0 chloride channel during slow gating. Nat Struct Mol Biol. 2006 Dec; 13(12):1115-9. PMID: 17115052.
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    32. Chen TY, Takeuchi H, Kurahashi T. Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly. J Gen Physiol. 2006 Sep; 128(3):365-71. PMID: 16940558.
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    33. Zhang XD, Li Y, Yu WP, Chen TY. Roles of K149, G352, and H401 in the channel functions of ClC-0: testing the predictions from theoretical calculations. J Gen Physiol. 2006 Apr; 127(4):435-47. PMID: 16567465.
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    34. Li Y, Yu WP, Lin CW, Chen TY. Oxidation and reduction control of the inactivation gating of Torpedo ClC-0 chloride channels. Biophys J. 2005 Jun; 88(6):3936-45. PMID: 15778445.
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    35. Chen TY. Structure and function of clc channels. Annu Rev Physiol. 2005; 67:809-39. PMID: 15709979.
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    36. Chen TY, Chen MF, Lin CW. Electrostatic control and chloride regulation of the fast gating of ClC-0 chloride channels. J Gen Physiol. 2003 Nov; 122(5):641-51. PMID: 14581587.
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    37. Chen MF, Chen TY. Side-chain charge effects and conductance determinants in the pore of ClC-0 chloride channels. J Gen Physiol. 2003 Aug; 122(2):133-45. PMID: 12885875.
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    38. Lin CW, Chen TY. Probing the pore of ClC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents. J Gen Physiol. 2003 Aug; 122(2):147-59. PMID: 12885876.
      View in: PubMed
    39. Chen TY. Coupling gating with ion permeation in ClC channels. Sci STKE. 2003 Jun 24; 2003(188):pe23. PMID: 12824475.
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    40. Chen MF, Chen TY. Different fast-gate regulation by external Cl(-) and H(+) of the muscle-type ClC chloride channels. J Gen Physiol. 2001 Jul; 118(1):23-32. PMID: 11429442.
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    41. Lin CW, Chen TY. Cysteine modification of a putative pore residue in ClC-0: implication for the pore stoichiometry of ClC chloride channels. J Gen Physiol. 2000 Oct; 116(4):535-46. PMID: 11004203.
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    42. Lin YW, Lin CW, Chen TY. Elimination of the slow gating of ClC-0 chloride channel by a point mutation. J Gen Physiol. 1999 Jul; 114(1):1-12. PMID: 10398688.
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    43. Chen TY. Extracellular zinc ion inhibits ClC-0 chloride channels by facilitating slow gating. J Gen Physiol. 1998 Dec; 112(6):715-26. PMID: 9834141.
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    44. Finn JT, Krautwurst D, Schroeder JE, Chen TY, Reed RR, Yau KW. Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human. Biophys J. 1998 Mar; 74(3):1333-45. PMID: 9512030.
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    45. Chen TY, Miller C. Nonequilibrium gating and voltage dependence of the ClC-0 Cl- channel. J Gen Physiol. 1996 Oct; 108(4):237-50. PMID: 8894974.
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    46. Liu M, Chen TY, Ahamed B, Li J, Yau KW. Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel. Science. 1994 Nov 25; 266(5189):1348-54. PMID: 7526466.
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    47. Chen TY, Illing M, Molday LL, Hsu YT, Yau KW, Molday RS. Subunit 2 (or beta) of retinal rod cGMP-gated cation channel is a component of the 240-kDa channel-associated protein and mediates Ca(2+)-calmodulin modulation. Proc Natl Acad Sci U S A. 1994 Nov 22; 91(24):11757-61. PMID: 7526403.
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    48. Chen TY, Yau KW. Direct modulation by Ca(2+)-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons. Nature. 1994 Apr 07; 368(6471):545-8. PMID: 7511217.
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    49. Yellen G, Sodickson D, Chen TY, Jurman ME. An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding. Biophys J. 1994 Apr; 66(4):1068-75. PMID: 8038379.
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    50. Chen TY, Peng YW, Dhallan RS, Ahamed B, Reed RR, Yau KW. A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature. 1993 Apr 22; 362(6422):764-7. PMID: 7682292.
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    51. Chiu TH, Chen TY, Ho CL, Chiang ST. Electrophysiological effects of dermorphin on locus coeruleus neurons of rat. Neuropharmacology. 1990 Aug; 29(8):747-55. PMID: 1980348.
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