Tsung-Yu Chen

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address502G 1515 Newton ct
CA 95618
Phone530-754-7166
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    Collapse Research 
    Collapse Research Activities and Funding
    Functions and Disorders of K Channels in the Ineer Ear
    NIH R01DC008649Apr 1, 2008 - Mar 31, 2014
    Role: Principal Investigator
    Molecular Physiology and Channelopathy of CLC Chloride Channels
    NIH R01GM065447Sep 1, 2003 - Aug 31, 2021
    Role: Principal Investigator
    Gating Mechanisms of CLC Chloride Channels
    NIH R56GM065447Sep 1, 2003 - Aug 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Odorant Inhibition in Mosquito Olfaction. iScience. 2019 Sep 27; 19:25-38. Xu P, Choo YM, Chen Z, Zeng F, Tan K, Chen TY, Cornel AJ, Liu N, Leal WS. PMID: 31349189; PMCID: PMC6660600.
      View in: PubMed   Mentions: 10  
    2. Comparison of ion transport determinants between a TMEM16 chloride channel and phospholipid scramblase. J Gen Physiol. 2019 04 01; 151(4):518-531. Nguyen DM, Chen LS, Yu WP, Chen TY. PMID: 30670476; PMCID: PMC6445582.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    3. FKBP8 Enhances Protein Stability of the CLC-1 Chloride Channel at the Plasma Membrane. Int J Mol Sci. 2018 Nov 28; 19(12). Peng YJ, Lee YC, Fu SJ, Chien YC, Liao YF, Chen TY, Jeng CJ, Tang CY. PMID: 30487393; PMCID: PMC6320802.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    4. Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans. Sci Rep. 2017 03 13; 7(1):169. O'Halloran DM, Altshuler-Keylin S, Zhang XD, He C, Morales-Phan C, Yu Y, Kaye JA, Brueggemann C, Chen TY, L'Etoile ND. PMID: 28279024; PMCID: PMC5427828.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    5. Independent activation of distinct pores in dimeric TMEM16A channels. J Gen Physiol. 2016 11; 148(5):393-404. Jeng G, Aggarwal M, Yu WP, Chen TY. PMID: 27799319; PMCID: PMC5089935.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    6. Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. Sci Rep. 2016 09 01; 6:32444. Peng YJ, Huang JJ, Wu HH, Hsieh HY, Wu CY, Chen SC, Chen TY, Tang CY. PMID: 27580824; PMCID: PMC5007535.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    7. Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. J Gen Physiol. 2016 Apr; 147(4):291-308. Pedersen TH, Riisager A, de Paoli FV, Chen TY, Nielsen OB. PMID: 27022190; PMCID: PMC4810071.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    8. Protein kinase C-dependent regulation of ClC-1 channels in active human muscle and its effect on fast and slow gating. J Physiol. 2016 06 15; 594(12):3391-406. Riisager A, de Paoli FV, Yu WP, Pedersen TH, Chen TY, Nielsen OB. PMID: 26857341; PMCID: PMC4908021.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    9. Modulation of the slow/common gating of CLC channels by intracellular cadmium. J Gen Physiol. 2015 Dec; 146(6):495-508. Yu Y, Tsai MF, Yu WP, Chen TY. PMID: 26621774; PMCID: PMC4664824.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels. Sci Rep. 2015 May 29; 5:10667. Chen YA, Peng YJ, Hu MC, Huang JJ, Chien YC, Wu JT, Chen TY, Tang CY. PMID: 26021757; PMCID: PMC4448132.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    11. Purified human brain calmodulin does not alter the bicarbonate permeability of the ANO1/TMEM16A channel. J Gen Physiol. 2015 Jan; 145(1):79-81. Yu Y, Chen TY. PMID: 25548138; PMCID: PMC4278188.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    12. Calcium-calmodulin does not alter the anion permeability of the mouse TMEM16A calcium-activated chloride channel. J Gen Physiol. 2014 Jul; 144(1):115-24. Yu Y, Kuan AS, Chen TY. PMID: 24981232; PMCID: PMC4076522.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    13. Activation and inhibition of TMEM16A calcium-activated chloride channels. PLoS One. 2014; 9(1):e86734. Ni YL, Kuan AS, Chen TY. PMID: 24489780; PMCID: PMC3906059.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    14. Myotonia congenita mutation enhances the degradation of human CLC-1 chloride channels. PLoS One. 2013; 8(2):e55930. Lee TT, Zhang XD, Chuang CC, Chen JJ, Chen YA, Chen SC, Chen TY, Tang CY. PMID: 23424641; PMCID: PMC3570542.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    15. Single myotonia mutation strikes multiple mechanisms of a chloride channel. J Physiol. 2012 Aug 01; 590(15):3407. Chen TY. PMID: 22855049; PMCID: PMC3547255.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Dominantly inherited myotonia congenita resulting from a mutation that increases open probability of the muscle chloride channel CLC-1. Neuromolecular Med. 2012 Dec; 14(4):328-37. Richman DP, Yu Y, Lee TT, Tseng PY, Yu WP, Maselli RA, Tang CY, Chen TY. PMID: 22790975; PMCID: PMC3508202.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    17. Intracellular β-nicotinamide adenine dinucleotide inhibits the skeletal muscle ClC-1 chloride channel. J Biol Chem. 2012 Jul 27; 287(31):25808-20. Bennetts B, Yu Y, Chen TY, Parker MW. PMID: 22689570; PMCID: PMC3406667.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    18. Influences of mutations on the electrostatic binding free energies of chloride ions in Escherichia coli ClC. J Phys Chem B. 2012 Jun 07; 116(22):6431-8. Yu T, Wang XQ, Sang JP, Pan CX, Zou XW, Chen TY, Zou X. PMID: 22612693; PMCID: PMC3411325.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    19. Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia. J Biomed Biotechnol. 2011; 2011:685328. Tang CY, Chen TY. PMID: 22187529; PMCID: PMC3237021.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    20. Binding of ATP to the CBS domains in the C-terminal region of CLC-1. J Gen Physiol. 2011 Apr; 137(4):357-68. Tseng PY, Yu WP, Liu HY, Zhang XD, Zou X, Chen TY. PMID: 21444658; PMCID: PMC3068280.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    21. Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas. Brain Res. 2010 Dec 02; 1363:159-69. Harley W, Floyd C, Dunn T, Zhang XD, Chen TY, Hegde M, Palandoken H, Nantz MH, Leon L, Carraway KL, Lyeth B, Gorin FA. PMID: 20869350; PMCID: PMC2996276.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    22. A three-state multi-ion kinetic model for conduction properties of ClC-0 chloride channel. Biophys J. 2010 Jul 21; 99(2):464-71. Wang XQ, Yu T, Sang JP, Zou XW, Chen TY, Bolser D, Zou X. PMID: 20643064; PMCID: PMC2905080.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    23. Chloride channels and transporters in human corneal epithelium. Exp Eye Res. 2010 Jun; 90(6):771-9. Cao L, Zhang XD, Liu X, Chen TY, Zhao M. PMID: 20346358; PMCID: PMC2873124.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    24. Accessibility of the CLC-0 pore to charged methanethiosulfonate reagents. Biophys J. 2010 Feb 03; 98(3):377-85. Zhang XD, Yu WP, Chen TY. PMID: 20141750; PMCID: PMC2814198.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    25. Amphiphilic blockers punch through a mutant CLC-0 pore. J Gen Physiol. 2009 Jan; 133(1):59-68. Zhang XD, Chen TY. PMID: 19088382; PMCID: PMC2606939.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    26. Blocking pore-open mutants of CLC-0 by amphiphilic blockers. J Gen Physiol. 2009 Jan; 133(1):43-58. Zhang XD, Tseng PY, Yu WP, Chen TY. PMID: 19088381; PMCID: PMC2606940.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    27. Membrane targeting and coupling of NHE1-integrinalphaIIbbeta3-NCX1 by lipid rafts following integrin-ligand interactions trigger Ca2+ oscillations. J Biol Chem. 2009 Feb 06; 284(6):3855-64. Yi YH, Ho PY, Chen TW, Lin WJ, Gukassyan V, Tsai TH, Wang DW, Lew TS, Tang CY, Lo SJ, Chen TY, Kao FJ, Lin CH. PMID: 18996841.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    28. ATP inhibition of CLC-1 is controlled by oxidation and reduction. J Gen Physiol. 2008 Oct; 132(4):421-8. Zhang XD, Tseng PY, Chen TY. PMID: 18824589; PMCID: PMC2553389.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    29. CLC-0 and CFTR: chloride channels evolved from transporters. Physiol Rev. 2008 Apr; 88(2):351-87. Chen TY, Hwang TC. PMID: 18391167.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    30. Cytoplasmic ATP inhibition of CLC-1 is enhanced by low pH. J Gen Physiol. 2007 Aug; 130(2):217-21. Tseng PY, Bennetts B, Chen TY. PMID: 17664348; PMCID: PMC2151639.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    31. Large movement in the C terminus of CLC-0 chloride channel during slow gating. Nat Struct Mol Biol. 2006 Dec; 13(12):1115-9. Bykova EA, Zhang XD, Chen TY, Zheng J. PMID: 17115052.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    32. Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly. J Gen Physiol. 2006 Sep; 128(3):365-71. Chen TY, Takeuchi H, Kurahashi T. PMID: 16940558; PMCID: PMC2151561.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    33. Roles of K149, G352, and H401 in the channel functions of ClC-0: testing the predictions from theoretical calculations. J Gen Physiol. 2006 Apr; 127(4):435-47. Zhang XD, Li Y, Yu WP, Chen TY. PMID: 16567465; PMCID: PMC2151512.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    34. Oxidation and reduction control of the inactivation gating of Torpedo ClC-0 chloride channels. Biophys J. 2005 Jun; 88(6):3936-45. Li Y, Yu WP, Lin CW, Chen TY. PMID: 15778445; PMCID: PMC1305625.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    35. Structure and function of clc channels. Annu Rev Physiol. 2005; 67:809-39. Chen TY. PMID: 15709979.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    36. Electrostatic control and chloride regulation of the fast gating of ClC-0 chloride channels. J Gen Physiol. 2003 Nov; 122(5):641-51. Chen TY, Chen MF, Lin CW. PMID: 14581587; PMCID: PMC2229583.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    37. Probing the pore of ClC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents. J Gen Physiol. 2003 Aug; 122(2):147-59. Lin CW, Chen TY. PMID: 12885876; PMCID: PMC2229544.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    38. Side-chain charge effects and conductance determinants in the pore of ClC-0 chloride channels. J Gen Physiol. 2003 Aug; 122(2):133-45. Chen MF, Chen TY. PMID: 12885875; PMCID: PMC2229543.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    39. Coupling gating with ion permeation in ClC channels. Sci STKE. 2003 Jun 24; 2003(188):pe23. Chen TY. PMID: 12824475.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    40. Different fast-gate regulation by external Cl(-) and H(+) of the muscle-type ClC chloride channels. J Gen Physiol. 2001 Jul; 118(1):23-32. Chen MF, Chen TY. PMID: 11429442; PMCID: PMC2233746.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    41. Cysteine modification of a putative pore residue in ClC-0: implication for the pore stoichiometry of ClC chloride channels. J Gen Physiol. 2000 Oct; 116(4):535-46. Lin CW, Chen TY. PMID: 11004203; PMCID: PMC2230621.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    42. Elimination of the slow gating of ClC-0 chloride channel by a point mutation. J Gen Physiol. 1999 Jul; 114(1):1-12. Lin YW, Lin CW, Chen TY. PMID: 10398688; PMCID: PMC2229640.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    43. Extracellular zinc ion inhibits ClC-0 chloride channels by facilitating slow gating. J Gen Physiol. 1998 Dec; 112(6):715-26. Chen TY. PMID: 9834141; PMCID: PMC2229451.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    44. Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human. Biophys J. 1998 Mar; 74(3):1333-45. Finn JT, Krautwurst D, Schroeder JE, Chen TY, Reed RR, Yau KW. PMID: 9512030; PMCID: PMC1299480.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    45. Nonequilibrium gating and voltage dependence of the ClC-0 Cl- channel. J Gen Physiol. 1996 Oct; 108(4):237-50. Chen TY, Miller C. PMID: 8894974; PMCID: PMC2229332.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    46. Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel. Science. 1994 Nov 25; 266(5189):1348-54. Liu M, Chen TY, Ahamed B, Li J, Yau KW. PMID: 7526466.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    47. Subunit 2 (or beta) of retinal rod cGMP-gated cation channel is a component of the 240-kDa channel-associated protein and mediates Ca(2+)-calmodulin modulation. Proc Natl Acad Sci U S A. 1994 Nov 22; 91(24):11757-61. Chen TY, Illing M, Molday LL, Hsu YT, Yau KW, Molday RS. PMID: 7526403; PMCID: PMC45311.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    48. Direct modulation by Ca(2+)-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons. Nature. 1994 Apr 07; 368(6471):545-8. Chen TY, Yau KW. PMID: 7511217.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    49. An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding. Biophys J. 1994 Apr; 66(4):1068-75. Yellen G, Sodickson D, Chen TY, Jurman ME. PMID: 8038379; PMCID: PMC1275814.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansAnimalsCells
    50. A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature. 1993 Apr 22; 362(6422):764-7. Chen TY, Peng YW, Dhallan RS, Ahamed B, Reed RR, Yau KW. PMID: 7682292.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    51. Electrophysiological effects of dermorphin on locus coeruleus neurons of rat. Neuropharmacology. 1990 Aug; 29(8):747-55. Chiu TH, Chen TY, Ho CL, Chiang ST. PMID: 1980348.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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