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Jeremy Chien

Title(s)Associate Professor, Biochemistry and Molecular Medicine
SchoolUniversity of California, Davis
Address2700 Stockton Blvd #2354
CA 95817
Phone916-734-4766
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Short-term organoid culture for drug sensitivity testing of high-grade serous carcinoma. Gynecol Oncol. 2020 Jun; 157(3):783-792. Chen H, Gotimer K, De Souza C, Tepper CG, Karnezis AN, Leiserowitz GS, Chien J, Smith LH. PMID: 32253045.
      View in: PubMed   Mentions:    Fields:    
    2. Coiled-Coil and C2 Domain-Containing Protein 1A (CC2D1A) Promotes Chemotherapy Resistance in Ovarian Cancer. Front Oncol. 2019; 9:986. Kumar S, Oien DB, Khurana A, Cliby W, Hartmann L, Chien J, Shridhar V. PMID: 31632917.
      View in: PubMed   Mentions:
    3. Genome-scale CRISPR knockout screen identifies TIGAR as a modifier of PARP inhibitor sensitivity. Commun Biol. 2019; 2:335. Fang P, De Souza C, Minn K, Chien J. PMID: 31508509.
      View in: PubMed   Mentions:
    4. Heterozygous mutations in valosin-containing protein (VCP) and resistance to VCP inhibitors. Sci Rep. 2019 07 29; 9(1):11002. Bastola P, Bilkis R, De Souza C, Minn K, Chien J. PMID: 31358864.
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    5. Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers. Int J Cancer. 2019 01 01; 144(1):178-189. Mondal S, Roy D, Sarkar Bhattacharya S, Jin L, Jung D, Zhang S, Kalogera E, Staub J, Wang Y, Xuyang W, Khurana A, Chien J, Telang S, Chesney J, Tapolsky G, Petras D, Shridhar V. PMID: 30226266.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. Emerging Cancer Therapeutic Targets in Protein Homeostasis. AAPS J. 2018 08 27; 20(6):94. Bastola P, Oien DB, Cooley M, Chien J. PMID: 30151644.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Olaparib-induced Adaptive Response Is Disrupted by FOXM1 Targeting that Enhances Sensitivity to PARP Inhibition. Mol Cancer Res. 2018 06; 16(6):961-973. Fang P, Madden JA, Neums L, Moulder RK, Forrest ML, Chien J. PMID: 29545475.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Genetic Evidence for Early Peritoneal Spreading in Pelvic High-Grade Serous Cancer. Front Oncol. 2018; 8:58. Chien J, Neums L, Powell AFLA, Torres M, Kalli KR, Multinu F, Shridhar V, Mariani A. PMID: 29594039.
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    9. Quinacrine upregulates p21/p27 independent of p53 through autophagy-mediated downregulation of p62-Skp2 axis in ovarian cancer. Sci Rep. 2018 02 06; 8(1):2487. Jung D, Khurana A, Roy D, Kalogera E, Bakkum-Gamez J, Chien J, Shridhar V. PMID: 29410485.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. VaDiR: an integrated approach to Variant Detection in RNA. Gigascience. 2018 02 01; 7(2). Neums L, Suenaga S, Beyerlein P, Anders S, Koestler D, Mariani A, Chien J. PMID: 29267927.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Co-selected mutations in VCP: a novel mechanism of resistance to VCP inhibitors. Cell Death Dis. 2018 01 18; 9(2):35. Bastola P, Chien J. PMID: 29348605.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Cisplatin and Pemetrexed Activate AXL and AXL Inhibitor BGB324 Enhances Mesothelioma Cell Death from Chemotherapy. Front Pharmacol. 2017; 8:970. Oien DB, Garay T, Eckstein S, Chien J. PMID: 29375377.
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    13. Specific mutations in the D1-D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors. Cell Death Discov. 2017; 3:17065. Bastola P, Wang F, Schaich MA, Gan T, Freudenthal BD, Chou TF, Chien J. PMID: 29367883.
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    14. Meeting Report From the 2016 11th Biennial Ovarian Cancer Research Symposium: Mechanisms of Initiation and Progression of Ovarian Cancers. Int J Gynecol Cancer. 2017 11; 27(9S Suppl 5):S10-S13. Chien J, Mehta G. PMID: 29278599.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    15. Ovarian Cancer Prevention, Screening, and Early Detection: Report From the 11th Biennial Ovarian Cancer Research Symposium. Int J Gynecol Cancer. 2017 11; 27(9S Suppl 5):S20-S22. Chien J, Poole EM. PMID: 29278600.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. digit-a tool for detection and identification of genomic interchromosomal translocations. Nucleic Acids Res. 2017 May 19; 45(9):e72. Meier R, Graw S, Beyerlein P, Koestler D, Molina JR, Chien J. PMID: 28132028.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Bevacizumab May Differentially Improve Ovarian Cancer Outcome in Patients with Proliferative and Mesenchymal Molecular Subtypes. Clin Cancer Res. 2017 Jul 15; 23(14):3794-3801. Kommoss S, Winterhoff B, Oberg AL, Konecny GE, Wang C, Riska SM, Fan JB, Maurer MJ, April C, Shridhar V, Kommoss F, du Bois A, Hilpert F, Mahner S, Baumann K, Schroeder W, Burges A, Canzler U, Chien J, Embleton AC, Parmar M, Kaplan R, Perren T, Hartmann LC, Goode EL, Dowdy SC, Pfisterer J. PMID: 28159814.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    18. Complete Transcriptome RNA-Seq. Methods Mol Biol. 2017; 1513:141-162. Miller DF, Yan P, Fang F, Buechlein A, Kroll K, Frankhouser D, Stump C, Stump P, Ford JB, Tang H, Michaels S, Matei D, Huang TH, Chien J, Liu Y, Rusch DB, Nephew KP. PMID: 27807835.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. The histone demethylase KDM4B regulates peritoneal seeding of ovarian cancer. Oncogene. 2017 05 04; 36(18):2565-2576. Wilson C, Qiu L, Hong Y, Karnik T, Tadros G, Mau B, Ma T, Mu Y, New J, Louie RJ, Gunewardena S, Godwin AK, Tawfik OW, Chien J, Roby KF, Krieg AJ. PMID: 27869162.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    20. VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal. Mol Oncol. 2016 12; 10(10):1559-1574. Bastola P, Neums L, Schoenen FJ, Chien J. PMID: 27729194.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    21. Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway. Transl Cancer Res. 2016 Sep; 5(Suppl 3):S514-S519. Oien DB, Chien J, Cheng N. PMID: 30542639.
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    22. TP53 mutations as a biomarker for high-grade serous ovarian cancer: are we there yet?. Translational Cancer Research. 2016 Aug 1; 5(S2):s264-s268. Derek B. Oien, Jeremy Chien. .
      View in: Publisher Site   Mentions:
    23. Changes in O-Linked N-Acetylglucosamine (O-GlcNAc) Homeostasis Activate the p53 Pathway in Ovarian Cancer Cells. J Biol Chem. 2016 09 02; 291(36):18897-914. de Queiroz RM, Madan R, Chien J, Dias WB, Slawson C. PMID: 27402830.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    24. Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors. Mol Oncol. 2016 08; 10(7):1099-117. Zhang L, Hapon MB, Goyeneche AA, Srinivasan R, Gamarra-Luques CD, Callegari EA, Drappeau DD, Terpstra EJ, Pan B, Knapp JR, Chien J, Wang X, Eyster KM, Telleria CM. PMID: 27233943.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. The degree of intratumor mutational heterogeneity varies by primary tumor sub-site. Oncotarget. 2016 May 10; 7(19):27185-98. Ledgerwood LG, Kumar D, Eterovic AK, Wick J, Chen K, Zhao H, Tazi L, Manna P, Kerley S, Joshi R, Wang L, Chiosea SI, Garnett JD, Tsue TT, Chien J, Mills GB, Grandis JR, Thomas SM. PMID: 27034009.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    26. A targeted genetic association study of epithelial ovarian cancer susceptibility. Oncotarget. 2016 Feb 16; 7(7):7381-9. Earp M, Winham SJ, Larson N, Permuth JB, Sicotte H, Chien J, Anton-Culver H, Bandera EV, Berchuck A, Cook LS, Cramer D, Doherty JA, Goodman MT, Levine DA, Monteiro AN, Ness RB, Pearce CL, Rossing MA, Tworoger SS, Wentzensen N, Bisogna M, Brinton L, Brooks-Wilson A, Carney ME, Cunningham JM, Edwards RP, Fogarty ZC, Iversen ES, Kraft P, Larson MC, Le ND, Lin HY, Lissowska J, Modugno F, Moysich KB, Olson SH, Pike MC, Poole EM, Rider DN, Terry KL, Thompson PJ, van den Berg D, Vierkant RA, Vitonis AF, Wilkens LR, Wu AH, Yang HP, Ziogas A, Phelan CM, Schildkraut JM, Chen YA, Sellers TA, Fridley BL, Goode EL. PMID: 26848776.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    27. Network-Based Isoform Quantification with RNA-Seq Data for Cancer Transcriptome Analysis. PLoS Comput Biol. 2015 Dec; 11(12):e1004465. Zhang W, Chang JW, Lin L, Minn K, Wu B, Chien J, Yong J, Zheng H, Kuang R. PMID: 26699225.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    28. Molecular determinants of chemotherapy resistance in ovarian cancer. Pharmacogenomics. 2015 Nov; 16(16):1763-7. Cooley M, Fang P, Fang F, Nephew KP, P Nephew K, Chien J. PMID: 26554863.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case. BMC Cancer. 2015 Nov 10; 15:887. Belinsky MG, Rink L, Cai KQ, Capuzzi SJ, Hoang Y, Chien J, Godwin AK, von Mehren M. PMID: 26555092.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    30. Targeted or whole genome sequencing of formalin fixed tissue samples: potential applications in cancer genomics. Oncotarget. 2015 Sep 22; 6(28):25943-61. Munchel S, Hoang Y, Zhao Y, Cottrell J, Klotzle B, Godwin AK, Koestler D, Beyerlein P, Fan JB, Bibikova M, Chien J. PMID: 26305677.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    31. Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. Breast Cancer Res. 2015 Sep 17; 17:128. Elsarraj HS, Hong Y, Valdez KE, Michaels W, Hook M, Smith WP, Chien J, Herschkowitz JI, Troester MA, Beck M, Inciardi M, Gatewood J, May L, Cusick T, McGinness M, Ricci L, Fan F, Tawfik O, Marks JR, Knapp JR, Yeh HW, Thomas P, Carrasco DR, Fields TA, Godwin AK, Behbod F. PMID: 26384318.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    32. Robust gene expression and mutation analyses of RNA-sequencing of formalin-fixed diagnostic tumor samples. Sci Rep. 2015 Jul 23; 5:12335. Graw S, Meier R, Minn K, Bloomer C, Godwin AK, Fridley B, Vlad A, Beyerlein P, Chien J. PMID: 26202458.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    33. Neonatal Progesterone Programs Adult Uterine Responses to Progesterone and Susceptibility to Uterine Dysfunction. Endocrinology. 2015 Oct; 156(10):3791-803. Dhakal P, Rumi MA, Kubota K, Chakraborty D, Chien J, Roby KF, Soares MJ. PMID: 26204463.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    34. Summary of the 2015 American Association for Cancer Research (AACR) Annual Meeting. Gynecol Oncol. 2015 Jul; 138(1):7-10. Chien J, Landen CN. PMID: 26269806.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    35. TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer. Nucleic Acids Res. 2015 Aug 18; 43(14):6945-58. Chien J, Sicotte H, Fan JB, Humphray S, Cunningham JM, Kalli KR, Oberg AL, Hart SN, Li Y, Davila JI, Baheti S, Wang C, Dietmann S, Atkinson EJ, Asmann YW, Bell DA, Ota T, Tarabishy Y, Kuang R, Bibikova M, Cheetham RK, Grocock RJ, Swisher EM, Peden J, Bentley D, Kocher JP, Kaufmann SH, Hartmann LC, Shridhar V, Goode EL. PMID: 25916844.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    36. PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samples. Eur J Cancer. 2015 May; 51(7):879-892. Winterhoff B, Freyer L, Hammond E, Giri S, Mondal S, Roy D, Teoman A, Mullany SA, Hoffmann R, von Bismarck A, Chien J, Block MS, Millward M, Bampton D, Dredge K, Shridhar V. PMID: 25754234.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    37. Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells. Oncotarget. 2014 Nov 30; 5(22):11365-80. Zhang X, Cheng L, Minn K, Madan R, Godwin AK, Shridhar V, Chien J. PMID: 25426548.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    38. Challenges and opportunities for next-generation sequencing in companion diagnostics. Expert Rev Mol Diagn. 2015 Feb; 15(2):193-209. Lin E, Chien J, Ong FS, Fan JB. PMID: 25249308.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Tumor hypomethylation at 6p21.3 associates with longer time to recurrence of high-grade serous epithelial ovarian cancer. Cancer Res. 2014 Jun 01; 74(11):3084-91. Wang C, Cicek MS, Charbonneau B, Kalli KR, Armasu SM, Larson MC, Konecny GE, Winterhoff B, Fan JB, Bibikova M, Chien J, Shridhar V, Block MS, Hartmann LC, Visscher DW, Cunningham JM, Knutson KL, Fridley BL, Goode EL. PMID: 24728075.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    40. Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD51C status. Sci Rep. 2014 Feb 07; 4:4026. Cunningham JM, Cicek MS, Larson NB, Davila J, Wang C, Larson MC, Song H, Dicks EM, Harrington P, Wick M, Winterhoff BJ, Hamidi H, Konecny GE, Chien J, Bibikova M, Fan JB, Kalli KR, Lindor NM, Fridley BL, Pharoah PP, Goode EL. PMID: 24504028.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    41. Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer. BMC Med Genomics. 2014 Jan 30; 7:8. Koestler DC, Chalise P, Cicek MS, Cunningham JM, Armasu S, Larson MC, Chien J, Block M, Kalli KR, Sellers TA, Fridley BL, Goode EL. PMID: 24479488.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    42. APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma. Cancer Res. 2013 Dec 15; 73(24):7222-31. Leonard B, Hart SN, Burns MB, Carpenter MA, Temiz NA, Rathore A, Vogel RI, Nikas JB, Law EK, Brown WL, Li Y, Zhang Y, Maurer MJ, Oberg AL, Cunningham JM, Shridhar V, Bell DA, April C, Bentley D, Bibikova M, Cheetham RK, Fan JB, Grocock R, Humphray S, Kingsbury Z, Peden J, Chien J, Swisher EM, Hartmann LC, Kalli KR, Goode EL, Sicotte H, Kaufmann SH, Harris RS. PMID: 24154874.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    43. Platinum-sensitive recurrence in ovarian cancer: the role of tumor microenvironment. Front Oncol. 2013 Sep 24; 3:251. Chien J, Kuang R, Landen C, Shridhar V. PMID: 24069583.
      View in: PubMed   Mentions:
    44. Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel. Hum Mol Genet. 2013 Aug 01; 22(15):3038-47. Cicek MS, Koestler DC, Fridley BL, Kalli KR, Armasu SM, Larson MC, Wang C, Winham SJ, Vierkant RA, Rider DN, Block MS, Klotzle B, Konecny G, Winterhoff BJ, Hamidi H, Shridhar V, Fan JB, Visscher DW, Olson JE, Hartmann LC, Bibikova M, Chien J, Cunningham JM, Goode EL. PMID: 23571109.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    45. Metformin Intake Is Associated With Better Survival in Ovarian Cancer. Obstetrical & Gynecological Survey. 2013 Apr 1; 68(4):293-294. Sanjeev Kumar, Alexandra Meuter, Prabin Thapa, Carrie Langstraat, Shailendra Giri, Jeremy Chien, Ramandeep Rattan, William Cliby, Viji Shridhar. .
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    46. Network-based survival analysis reveals subnetwork signatures for predicting outcomes of ovarian cancer treatment. PLoS Comput Biol. 2013; 9(3):e1002975. Zhang W, Ota T, Shridhar V, Chien J, Wu B, Kuang R. PMID: 23555212.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    47. Assessment of resistance to anoikis in ovarian cancer. Methods Mol Biol. 2013; 1049:347-54. He X, Chien J, Shridhar V. PMID: 23913229.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    48. Chapter 571 HtrA1 Peptidase. . 2013 Jan 1; 2577-2584. Jeremy Chien, Viji Shridhar. .
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    49. Metformin intake is associated with better survival in ovarian cancer: a case-control study. Cancer. 2013 Feb 01; 119(3):555-62. Kumar S, Meuter A, Thapa P, Langstraat C, Giri S, Chien J, Rattan R, Cliby W, Shridhar V. PMID: 23208739.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    50. Highly parallel genome-wide expression analysis of single mammalian cells. PLoS One. 2012; 7(2):e30794. Fan JB, Chen J, April CS, Fisher JS, Klotzle B, Bibikova M, Kaper F, Ronaghi M, Linnarsson S, Ota T, Chien J, Laurent LC, Loring JF, Nisperos SV, Chen GY, Zhong JF. PMID: 22347404.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    51. Assessment of hepatocyte growth factor in ovarian cancer mortality. Cancer Epidemiol Biomarkers Prev. 2011 Aug; 20(8):1638-48. Goode EL, Chenevix-Trench G, Hartmann LC, Fridley BL, Kalli KR, Vierkant RA, Larson MC, White KL, Keeney GL, Oberg TN, Cunningham JM, Beesley J, Johnatty SE, Chen X, Goodman KE, Armasu SM, Rider DN, Sicotte H, Schmidt MM, Elliott EA, Høgdall E, Kjær SK, Fasching PA, Ekici AB, Lambrechts D, Despierre E, Høgdall C, Lundvall L, Karlan BY, Gross J, Brown R, Chien J, Duggan DJ, Tsai YY, Phelan CM, Kelemen LE, Peethambaram PP, Schildkraut JM, Shridhar V, Sutphen R, Couch FJ, Sellers TA. PMID: 21724856.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    52. Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29; 474(7353):609-15. PMID: 21720365.
      View in: PubMed   Mentions: 2170     Fields:    Translation:HumansCells
    53. FusionHunter: identifying fusion transcripts in cancer using paired-end RNA-seq. Bioinformatics. 2011 Jun 15; 27(12):1708-10. Li Y, Chien J, Smith DI, Ma J. PMID: 21546395.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    54. HtrA1 sensitizes ovarian cancer cells to cisplatin-induced cytotoxicity by targeting XIAP for degradation. Int J Cancer. 2012 Mar 01; 130(5):1029-35. He X, Khurana A, Maguire JL, Chien J, Shridhar V. PMID: 21387310.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    55. HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cells. Cancer Res. 2011 Mar 15; 71(6):2152-61. Khurana A, Liu P, Mellone P, Lorenzon L, Vincenzi B, Datta K, Yang B, Linhardt RJ, Lingle W, Chien J, Baldi A, Shridhar V. PMID: 21266348.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    56. Expression and functional significance of HtrA1 loss in endometrial cancer. Clin Cancer Res. 2011 Feb 01; 17(3):427-36. Mullany SA, Moslemi-Kebria M, Rattan R, Khurana A, Clayton A, Ota T, Mariani A, Podratz KC, Chien J, Shridhar V. PMID: 21098697.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    57. Comparison of gene expression patterns between avian and human ovarian cancers. Gynecol Oncol. 2011 Feb; 120(2):256-64. Gonzalez Bosquet J, Peedicayil A, Maguire J, Chien J, Rodriguez GC, Whitaker R, Petitte JN, Anderson KE, Barnes HJ, Shridhar V, Cliby WA. PMID: 21093898.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    58. Minichromosome maintenance protein 7 as a potential prognostic factor for progression-free survival in high-grade serous carcinomas of the ovary. Mod Pathol. 2011 Feb; 24(2):277-87. Ota T, Clayton AC, Minot DM, Shridhar V, Hartmann LC, Gilks CB, Chien JR. PMID: 21076460.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    59. WT1 as a substrate of HtrA2: a potential pathway for therapeutic targeting by HtrA proteases. Future Oncol. 2010 Aug; 6(8):1233-5. Chien J. PMID: 20799869.
      View in: PubMed   Mentions: 1     Fields:    
    60. Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells. Cancer Res. 2010 Apr 15; 70(8):3109-18. He X, Ota T, Liu P, Su C, Chien J, Shridhar V. PMID: 20388781.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    61. High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines. J Biol Chem. 2010 Apr 16; 285(16):12011-27. Beleford D, Rattan R, Chien J, Shridhar V. PMID: 20154083.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    62. TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway. Oncogene. 2010 Mar 04; 29(9):1362-73. Rattan R, Narita K, Chien J, Maguire JL, Shridhar R, Giri S, Shridhar V. PMID: 19966855.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    63. HtrA serine proteases as potential therapeutic targets in cancer. Curr Cancer Drug Targets. 2009 Jun; 9(4):451-68. Chien J, Campioni M, Shridhar V, Baldi A. PMID: 19519315.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    64. Serine protease HtrA1 associates with microtubules and inhibits cell migration. Mol Cell Biol. 2009 Aug; 29(15):4177-87. Chien J, Ota T, Aletti G, Shridhar R, Boccellino M, Quagliuolo L, Baldi A, Shridhar V. PMID: 19470753.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    65. Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening. J Cell Biochem. 2009 May 15; 107(2):253-63. Chien J, He X, Shridhar V. PMID: 19301262.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    66. Analysis of gene expression in stage I serous tumors identifies critical pathways altered in ovarian cancer. Gynecol Oncol. 2009 Jul; 114(1):3-11. Chien J, Fan JB, Bell DA, April C, Klotzle B, Ota T, Lingle WL, Gonzalez Bosquet J, Shridhar V, Hartmann LC. PMID: 19410283.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    67. Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. Journal of Clinical Investigation. 2009 May 1; 119(5):1396-1396. Zhenglin Yang, Yali Chen, Concepcion Lillo, Jeremy Chien, Zhengya Yu, Michel Michaelides, Martin Klein, Kim A. Howes, Yang Li, Yuuki Kaminoh, Haoyu Chen, Chao Zhao, Yuhong Chen, Youssef Tawfik Al-Sheikh, Goutam Karan, Denis Corbeil, Pascal Escher, Shin Kamaya, Chunmei Li, Samantha Johnson, Jeanne M. Frederick, Yu Zhao, Changguan Wang, D. Joshua Cameron, Wieland B. Huttner, Daniel F. Schorderet, Frances L. Munier, Anthony T. Moore, David G. Birch, Wolfgang Baehr, David M. Hunt, David S. Williams, Kang Zhang. .
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    68. A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation. Oncogene. 2008 Dec 11; 27(58):7223-34. Chien J, Narita K, Rattan R, Giri S, Shridhar R, Staub J, Beleford D, Lai J, Roberts LR, Molina J, Kaufmann SH, Prendergast GC, Shridhar V. PMID: 18806825.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    69. Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest. 2008 Aug; 118(8):2908-16. Yang Z, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, Klein M, Howes KA, Li Y, Kaminoh Y, Chen H, Zhao C, Chen Y, Al-Sheikh YT, Karan G, Corbeil D, Escher P, Kamaya S, Li C, Johnson S, Frederick JM, Zhao Y, Wang C, Cameron DJ, Huttner WB, Schorderet DF, Munier FL, Moore AT, Birch DG, Baehr W, Hunt DM, Williams DS, Zhang K. PMID: 18654668.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    70. The serine protease HtrA1 is a novel prognostic factor for human mesothelioma. Pharmacogenomics. 2008 Aug; 9(8):1069-77. Baldi A, Mottolese M, Vincenzi B, Campioni M, Mellone P, Di Marino M, di Crescenzo VG, Visca P, Menegozzo S, Spugnini EP, Citro G, Ceribelli A, Mirri A, Chien J, Shridhar V, Ehrmann M, Santini M, Facciolo F. PMID: 18681782.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    71. Elevated expression of serine protease HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion. Am J Obstet Gynecol. 2008 Nov; 199(5):557.e1-10. Ajayi F, Kongoasa N, Gaffey T, Asmann YW, Watson WJ, Baldi A, Lala P, Shridhar V, Brost B, Chien J. PMID: 18667191.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    72. Molecular pathogenesis and therapeutic targets in epithelial ovarian cancer. J Cell Biochem. 2007 Dec 01; 102(5):1117-29. Chien JR, Aletti G, Bell DA, Keeney GL, Shridhar V, Hartmann LC. PMID: 17879946.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    73. Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer. J Biol Chem. 2007 May 11; 282(19):14413-20. Narita K, Chien J, Mullany SA, Staub J, Qian X, Lingle WL, Shridhar V. PMID: 17363371.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    74. Epigenetic silencing of HSulf-1 in ovarian cancer:implications in chemoresistance. Oncogene. 2007 Jul 26; 26(34):4969-78. Staub J, Chien J, Pan Y, Qian X, Narita K, Aletti G, Scheerer M, Roberts LR, Molina J, Shridhar V. PMID: 17310998.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    75. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science. 2006 Nov 10; 314(5801):992-3. Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K. PMID: 17053109.
      View in: PubMed   Mentions: 257     Fields:    Translation:HumansCells
    76. Piroxicam and cisplatin in a mouse model of peritoneal mesothelioma. Clin Cancer Res. 2006 Oct 15; 12(20 Pt 1):6133-43. Spugnini EP, Cardillo I, Verdina A, Crispi S, Saviozzi S, Calogero R, Nebbioso A, Altucci L, Cortese G, Galati R, Chien J, Shridhar V, Vincenzi B, Citro G, Cognetti F, Sacchi A, Baldi A. PMID: 17062690.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    77. DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein. Biochem Biophys Res Commun. 2006 Aug 18; 347(1):22-30. Wang X, Zheng L, Zeng Z, Zhou G, Chien J, Qian C, Vasmatzis G, Shridhar V, Chen L, Liu W. PMID: 16814745.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    78. HSulf-1 inhibits angiogenesis and tumorigenesis in vivo. Cancer Res. 2006 Jun 15; 66(12):6025-32. Narita K, Staub J, Chien J, Meyer K, Bauer M, Friedl A, Ramakrishnan S, Shridhar V. PMID: 16778174.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    79. Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity. J Clin Invest. 2006 Jul; 116(7):1994-2004. Chien J, Aletti G, Baldi A, Catalano V, Muretto P, Keeney GL, Kalli KR, Staub J, Ehrmann M, Cliby WA, Lee YK, Bible KC, Hartmann LC, Kaufmann SH, Shridhar V. PMID: 16767218.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    80. Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance. Cancer Res. 2005 Aug 15; 65(16):7091-5. Lewis KA, Mullany S, Thomas B, Chien J, Loewen R, Shridhar V, Cliby WA. PMID: 16103057.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    81. Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer. Oncogene. 2005 Jul 28; 24(32):5089-100. Chien J, Staub J, Avula R, Zhang H, Liu W, Hartmann LC, Kaufmann SH, Smith DI, Shridhar V. PMID: 15870691.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    82. A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer. Oncogene. 2004 Feb 26; 23(8):1636-44. Chien J, Staub J, Hu SI, Erickson-Johnson MR, Couch FJ, Smith DI, Crowl RM, Kaufmann SH, Shridhar V. PMID: 14716297.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    83. HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma. Oncogene. 2004 Feb 19; 23(7):1439-47. Lai JP, Chien J, Strome SE, Staub J, Montoya DP, Greene EL, Smith DI, Roberts LR, Shridhar V. PMID: 14973553.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    84. hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling. Gastroenterology. 2004 Jan; 126(1):231-48. Lai JP, Chien JR, Moser DR, Staub JK, Aderca I, Montoya DP, Matthews TA, Nagorney DM, Cunningham JM, Smith DI, Greene EL, Shridhar V, Roberts LR. PMID: 14699503.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    85. Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer. J Biol Chem. 2003 Jun 20; 278(25):23107-17. Lai J, Chien J, Staub J, Avula R, Greene EL, Matthews TA, Smith DI, Kaufmann SH, Roberts LR, Shridhar V. PMID: 12686563.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCells
    86. Identification of underexpressed genes in early- and late-stage primary ovarian tumors by suppression subtraction hybridization. Cancer Res. 2002 Jan 01; 62(1):262-70. Shridhar V, Sen A, Chien J, Staub J, Avula R, Kovats S, Lee J, Lillie J, Smith DI. PMID: 11782386.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    87. Calcitonin is expressed in gonadotropes of the anterior pituitary gland: its possible role in paracrine regulation of lactotrope function. J Endocrinol. 2001 Nov; 171(2):217-28. Ren Y, Chien J, Sun YP, Shah GV. PMID: 11691641.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    88. Calcitonin is a prostate epithelium-derived growth stimulatory peptide. Mol Cell Endocrinol. 2001 Jul 05; 181(1-2):69-79. Chien J, Ren Y, Qing Wang Y, Bordelon W, Thompson E, Davis R, Rayford W, Shah G. PMID: 11476942.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    89. Role of stimulatory guanine nucleotide binding protein (GSalpha) in proliferation of PC-3M prostate cancer cells. Int J Cancer. 2001 Jan 01; 91(1):46-54. Chien J, Shah GV. PMID: 11149419.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    90. Calcitonin inhibits anterior pituitary cell proliferation in the adult female rats. Endocrinology. 1999 Sep; 140(9):4281-91. Shah GV, Chien J, Sun YP, Puri S, Ravindra R. PMID: 10465302.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    91. Constitutive activation of stimulatory guanine nucleotide binding protein (G(S)alphaQL)-mediated signaling increases invasiveness and tumorigenicity of PC-3M prostate cancer cells. Oncogene. 1999 Jun 03; 18(22):3376-82. Chien J, Wong E, Nikes E, Noble MJ, Pantazis CG, Shah GV. PMID: 10362358.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
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